About Nucleolus Knowledge Base (NKB)
Comprehensive platform for nucleolus biology research
What is NKB?
The Nucleolus Knowledge Base (NKB) is a curated, publicly accessible platform dedicated to nucleolus biology and its relevance to human diseases. It integrates high-confidence data from literature (e.g., PubMed) into structured knowledge entries and interactive knowledge graphs. Designed to support both basic and translational research, NKB provides tools for exploring molecular relationships, functional annotations, and disease associations centered on the nucleolus.
Why NKB?
The nucleolus, the largest phase-separated cellular compartment responsible for ribosome RNA biogenesis and ribosomal subunit assembly, plays a pivotal role in sustaining the biosynthetic demands of live cells. The nucleolus is increasingly recognized as a regulatory hub involved in diverse cellular processes and disease mechanisms, including cancer and neurodegeneration. However, comprehensive, structured resources focused on nucleolar biology have been lacking. NKB aims to fill this gap by offering a centralized, reliable, and continually updated knowledge infrastructure for the scientific community.
Who We Are ？
NKB is jointly developed by Shenzhen University and the Turing-Darwin Laboratory. The project is led by Dr. Yanxiang Ni, with contributions from specialists in bioinformatics, data science, and molecular biology. Oversight is provided by a Scientific Advisory Board to ensure academic rigor and methodological soundness.
Data Structure and Maintenance
All knowledge in NKB is organized in a triplet format (subject–predicate–object) with assigned confidence scores. The platform follows a long-term data stewardship policy, including periodic updates, version tracking, and secure archiving, supported by the data infrastructure of the Turing-Darwin Laboratory.
Funding and Support
NKB is supported by the Scientific Foundation for Youth Scholars of Shenzhen University, with institutional infrastructure provided by both Shenzhen University and the Turing-Darwin Laboratory.
Contact Information
Address
Institute of Microscale Optoelectronics
Yuehai Campus, Shenzhen University
Nanhai Avenue, Nanshan District
Shenzhen, Guangdong, China