Confidence：high
A total of 2260 records found
#22252
high Confidence
Subject:
clinical_follow_up
(Clinical follow-up)
→
was_available_on
→
Object:
ten_cases
(10 cases)
Original: clinical follow up#was available on#10 cases with a mean duration of 24 months
#22251
high Confidence
Subject:
patients_ages
(Patient age)
→
ranged_from
→
Object:
age_range_52_to_79
(Age range 52 to 79)
Original: their ages#ranged from#52 to 79 years
#22250
high Confidence
Subject:
elderly_man
(Older men)
→
was_found_to_have
→
Object:
large_left_renal_mass
(Large left kidney mass)
Original: 63-year-old man#was found to have#a large left renal mass
#22249
high Confidence
Subject:
study
(Research)
→
included
→
Object:
eight_cases
(8 cases)
Original: Study#included#8 cases of inpatients diagnosed with testicular tumors
#22248
high Confidence
Subject:
elderly_male
(Older men)
→
presented_with
→
Object:
breathlessness
(Shortness of breath)
Original: 65-year-old man#presented with#dry cough and breathlessness
#22247
high Confidence
Subject:
elderly_male
(Older men)
→
presented_with
→
Object:
dry_cough
(dry cough)
Original: 65-year-old man#presented with#dry cough and breathlessness
#22246
high Confidence
Subject:
middle_aged_male
(Middle-aged men)
→
presents_with
→
Object:
scrotal_swelling
(Scrotal swelling)
Original: 40-year-old man#presents with#right-sided scrotal swelling
#22245
high Confidence
Subject:
patient
(patient)
→
died
→
Object:
death_after_procedure
(Death after operation)
Original: Patient#died two days after#aspiration cytology
#22244
high Confidence
Subject:
young_adult_male
(Young adult male)
→
presented_with
→
Object:
enlarged_cervical_lymph_node
(Swollen lymph nodes in the neck)
Original: A 20-year-old man#presented with#an enlarged left upper cervical lymph node
#22243
high Confidence
Subject:
B_lineage_ALL_with_mature_phenotype
(Mature phenotype B-lineage acute lymphoblastic leukemia)
→
is_classified_as
→
Object:
precursor_B_lymphoblastic_leukemia_lymphoma
(Precursor B-cell leukemia lymphoma)
Original: B-lineage ALL with a mature phenotype#is classified as#precursor B-lymphoblastic leukemia/lymphoma
#22242
high Confidence
Subject:
patients_ages
(Patient age)
→
ranged_from
→
Object:
age_range_48_to_82
(Age range: 48-82 years old)
Original: Patients' ages#ranged from#48 to 82 years (median/ 68 years) at therapy initiation
#22241
high Confidence
Subject:
age_sex_matched_patients
(Age and sex matched patients)
→
were_included_as
→
Object:
control_group
(Control group)
Original: Age- and sex-matched patients#were included as#control group
#22240
high Confidence
Subject:
hepatic_flexure_colon_tumor
(Hepatic flexure colon tumor)
→
occurred_in
→
Object:
elderly_female_patient
(Elderly female patients)
Original: A hepatic flexure colon tumor#occurred in#a 61-year-old woman with no primary lung cancer lesion
#22239
high Confidence
Subject:
elderly_male_patient
(Elderly male patients)
→
was_admitted_for
→
Object:
subcutaneous_giant_mass
(Huge subcutaneous mass)
Original: A 78-year-old man#was admitted for#chest pain and a subcutaneous giant mass in the left chest
#22238
high Confidence
Subject:
elderly_male_patient
(Elderly male patients)
→
was_admitted_for
→
Object:
chest_pain
(Chest pain)
Original: A 78-year-old man#was admitted for#chest pain and a subcutaneous giant mass in the left chest
#22237
high Confidence
Subject:
patient
(patient)
→
died
→
Object:
death_within_time
(Time of death)
Original: Patient#died#3.5 months after biopsy-based histological diagnosis
#22236
high Confidence
Subject:
TFEB_break-apart_FISH_assay
(Molecular detection technology)
→
supports
→
Object:
TFEB_RCC
(Kidney Cancer Subtypes)
Original: TFEB break-apart FISH assay#supports#diagnosis of TFEB RCC
#22235
high Confidence
Subject:
ovarian_mature_cystic_teratoma
(Ovarian tumors)
→
occurs_in
→
Object:
0.2-1.8_percent_of_cases
(Epidemiological parameters)
Original: ovarian mature cystic teratoma#occurs in#0.2-1.8% of cases
#22234
high Confidence
Subject:
Burkitt's_lymphoma
(Tumor)
→
diagnosed_through
→
Object:
aspiration_cytology
(Diagnostic techniques)
Original: Burkitt's lymphoma#is diagnosed through#aspiration cytology
#22233
high Confidence
Subject:
HPD
(protein)
→
is_potential_therapeutic_target_for
→
Object:
breast_cancer
(Malignant tumors)
Original: HPD#is a potential therapeutic target for#patients with breast cancer
#22232
high Confidence
Subject:
patient_2
(Patient 2)
→
had
→
Object:
allogeneic_BMT
(Allogeneic bone marrow transplantation)
Original: Patient 2#had#allogeneic BMT
#22231
high Confidence
Subject:
epithelioid_AML
(Epithelioid angiomyolipoma)
→
were_compared_by
→
Object:
patient_demographics
(Patient demographic characteristics)
Original: Classic and epithelioid AML#were compared by#patients' demographics/ mode of presentation/ tumor features/ and follow-up data
#22230
high Confidence
Subject:
classic_AML
(Typical angiomyolipoma)
→
were_compared_by
→
Object:
patient_demographics
(Patient demographic characteristics)
Original: Classic and epithelioid AML#were compared by#patients' demographics/ mode of presentation/ tumor features/ and follow-up data
#22229
high Confidence
Subject:
tumor
(Tumor)
→
was_diagnosed_as
→
Object:
SCNEC_of_thyroid
(Small cell neuroendocrine carcinoma of the thyroid)
Original: tumor#was diagnosed as#SCNEC of the thyroid
#22228
high Confidence
Subject:
nephrectomy_specimen
(Nephrectomy specimen)
→
contained
→
Object:
confined_mass
(Localized mass)
Original: nephrectomy specimen#contained#a 14.8-cm mass confined within renal capsule
#22227
high Confidence
Subject:
primary_testicular_lymphomas
(Primary testicular lymphoma)
→
represent
→
Object:
percentage_of_testicular_tumors
(Testicular tumor ratio)
Original: Primary testicular lymphomas#represent#1-2% of non-Hodgkin lymphoma and 1-7% of malignant testicular tumors
#22226
high Confidence
Subject:
primary_testicular_lymphomas
(Primary testicular lymphoma)
→
represent
→
Object:
percentage_of_non_hodgkin_lymphoma
(Non-Hodgkin's lymphoma)
Original: Primary testicular lymphomas#represent#1-2% of non-Hodgkin lymphoma and 1-7% of malignant testicular tumors
#22225
high Confidence
Subject:
patient
(patient)
→
was_treated_with
→
Object:
primary_radical_radiotherapy
(Radical radiotherapy)
Original: Patient#was treated with#primary radical radiotherapy
#22224
high Confidence
Subject:
ASCUS
(Atypical squamous cells of undetermined significance)
→
has_been_area_of
→
Object:
The controversy
(dispute)
Original: Atypical squamous cells of undetermined significance (ASCUS)#has been an area of#controversy in cervical cytologic smears
#22223
high Confidence
Subject:
hormonally_treated_prostatic_cancer_cases
(Prostate cancer cases)
→
were_studied_in
→
Object:
prospective_study
(Prospective studies)
Original: Hormonally treated prostatic cancer cases#were studied in#a prospective study with sequential transrectal palpation and fine-needle aspiration
#22222
high Confidence
Subject:
CD10
(Protease)
→
is_observed_in
→
Object:
renal_cell_carcinoma
(Renal cell carcinoma)
Original: CD10 immunoreactivity#was observed in#more than 90% of RCC
#22221
high Confidence
Subject:
STK11
(Protein coding genes)
→
is_associated_with
→
Object:
Peutz-Jeghers_syndrome
(Genetic syndromes)
Original: STK11 adnexal tumor#is associated with#Peutz-Jeghers syndrome
#22220
high Confidence
Subject:
ribosomal_proteins
(Protein complex)
→
activate
→
Object:
p53_pathway
(signaling pathway)
Original: Ribosomal proteins#activate#p53 tumor suppressor pathway
#22219
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
is_hub_of
→
Object:
ribosome_biogenesis
(Molecular complex function)
Original: Nucleolus#is#hub of ribosome biogenesis
#22218
high Confidence
Subject:
Calpain_3
(Protease)
→
is_associated_with
→
Object:
limb-girdle_muscular_dystrophy_type_2A
(disease)
Original: Calpain 3 alterations#are associated with#limb-girdle muscular dystrophy type 2A
#22217
high Confidence
Subject:
CIC_DUX4_sarcoma_cases
(CIC-DUX4 sarcoma case)
→
were_identified_using
→
Object:
FISH_methods
(FISH method)
Original: CIC-DUX4 sarcoma cases#were identified using#cytogenetic/ RT-PCR/ and FISH methods
#22216
high Confidence
Subject:
CIC_DUX4_sarcoma_cases
(CIC-DUX4 sarcoma case)
→
were_identified_using
→
Object:
RT_PCR_methods
(RT-PCR method)
Original: CIC-DUX4 sarcoma cases#were identified using#cytogenetic/ RT-PCR/ and FISH methods
#22215
high Confidence
Subject:
CIC_DUX4_sarcoma_cases
(CIC-DUX4 sarcoma case)
→
were_identified_using
→
Object:
cytogenetic_methods
(Cytogenetic methods)
Original: CIC-DUX4 sarcoma cases#were identified using#cytogenetic/ RT-PCR/ and FISH methods
#22214
high Confidence
Subject:
patients
(patient)
→
were_treated_for
→
Object:
undifferentiated_carcinoma_of_urinary_bladder
(Undifferentiated bladder cancer)
Original: patients#were treated for#undifferentiated carcinoma of the urinary bladder
#22213
high Confidence
Subject:
all_patients
(All patients)
→
received
→
Object:
doxorubicin_based_chemotherapy
(Doxorubicin-based chemotherapy)
Original: All patients#received#a doxorubicin-based chemotherapy regimen (CHOP/ MTX/ CVP/ and Leukeran)
#22212
high Confidence
Subject:
cytological_signs
(Cytological signs)
→
are_defined_as
→
Object:
important_differentiation_markers
(Important identification marks)
Original: Cytological signs#are defined as#important for differentiation of PH and PDAC
#22211
high Confidence
Subject:
epididymis
(Epididymis)
→
is
→
Object:
most_common_site
(Most common sites)
Original: Epididymis#is#the most common site of involvement
#22210
high Confidence
Subject:
excisional_surgery
(Resection surgery)
→
is
→
Object:
adequate_treatment
(Adequate treatment)
Original: Excisional surgery#is#adequate treatment
#22209
high Confidence
Subject:
endometrial_biopsy_specimens
(Endometrial biopsy specimen)
→
represent
→
Object:
spectrum_of_proliferative_lesions
(Proliferative lesion spectrum)
Original: Endometrial biopsy specimens#represent#the spectrum of proliferative lesions including PEM/ hyperplasia/ AH/ and carcinoma
#22208
high Confidence
Subject:
squamous_metaplasia
(Squamous metaplasia)
→
showed
→
Object:
significant_difference
(Significant Differences)
Original: Squamous metaplasia#showed#a significant difference between benign state and malignancy
#22207
high Confidence
Subject:
asthenia
(Fatigue)
→
could_be
→
Object:
chief_complaints
(Main complaint)
Original: Hematuria and asthenia#could be#chief complaints
#22206
high Confidence
Subject:
hematuria
(hematuria)
→
could_be
→
Object:
chief_complaints
(Main complaint)
Original: Hematuria and asthenia#could be#chief complaints
#22205
high Confidence
Subject:
spindle_proliferations
(Spindle cell hyperplasia)
→
constituted
→
Object:
primary_neoplasm_percentage
(Primary tumor ratio)
Original: spindle proliferations#constituted#from 1% to 95% of the primary neoplasm
#22204
high Confidence
Subject:
tumor
(Tumor)
→
is_diagnosed_as
→
Object:
diffuse_intrapulmonary_malignant_mesothelioma
(Diffuse malignant pulmonary mesothelioma)
Original: tumor#is diagnosed as#diffuse intrapulmonary malignant mesothelioma (DIMM)
#22203
high Confidence
Subject:
Schwann_cells
(Cell Type)
→
are_positive_for
→
Object:
S100
(protein)
Original: Schwann cells#are positive for#S100
#22202
high Confidence
Subject:
MAPK/ERK_pathway_mutations
(Signaling pathway mutations)
→
were_found_in
→
Object:
Rosai-Dorfman_disease_cases
(disease)
Original: MAPK/ERK pathway mutations#were found in#30% to 50% of Rosai-Dorfman disease cases
#22201
high Confidence
Subject:
polymorphous_adenocarcinoma
(Tumor type)
→
is_associated_with
→
Object:
high_10-year_overall_survival_rate
(Clinical Outcomes)
Original: polymorphous adenocarcinoma#is associated with#a high 10-year overall survival rate (92.9%)
#22200
high Confidence
Subject:
rhabdomyoma
(Benign tumors)
→
is_a
→
Object:
benign_tumor
(Disease phenotype)
Original: Rhabdomyomas#are#rare benign tumors of striated muscle
#22199
high Confidence
Subject:
nucleolus
(Organelles)
→
is
→
Object:
subnuclear_compartment
(Subcellular structure)
Original: nucleolus#is#a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis
#22198
high Confidence
Subject:
nucleolus
(Organelles)
→
is
→
Object:
largest_membraneless_organelle
(Subcellular structure)
Original: nucleolus#is#the largest membraneless organelle and nuclear body in mammalian cells
#22197
high Confidence
Subject:
Nucleolar_Organizer_Regions
(Nucleolar organizing region)
→
encode
→
Object:
ribosomal_RNA
(Ribosomal RNA)
Original: Nucleolar Organizer Regions (NORs)#encode#ribosomal RNA
#22196
high Confidence
Subject:
histopathological_evaluation
(Detection Methods)
→
is_essential_for
→
Object:
correct_diagnosis
(Diagnosis conclusion)
Original: histopathological evaluation#is essential for#correct diagnosis
#22195
high Confidence
Subject:
rhabdomyosarcoma
(Tumor type)
→
is
→
Object:
malignant_tumor
(Disease characteristics)
Original: rhabdomyosarcomas#are#malignant tumors with skeletal muscle differentiation
#22194
high Confidence
Subject:
NUT_locus_rearrangement
(Gene rearrangement)
→
is_associated_with
→
Object:
NUT_midline_carcinoma
(Tumor type)
Original: NUT locus rearrangements#are associated with#NUT midline carcinoma
#22193
high Confidence
Subject:
Immunohistochemistry
(Detection Methods)
→
distinguishes
→
Object:
other_small_round_cell_tumors
(Tumor type)
Original: immunohistochemistry#distinguishes#Ewing sarcoma from other small round cell tumors
#22192
high Confidence
Subject:
Immunohistochemistry
(Detection Methods)
→
distinguishes
→
Object:
Ewing_sarcoma
(Tumor type)
Original: immunohistochemistry#distinguishes#Ewing sarcoma from other small round cell tumors
#22191
high Confidence
Subject:
Immunohistochemistry
(Histological detection technology)
→
is_widely_used_in
→
Object:
clinical_diagnosis_of_prostatic_carcinoma
(Clinical diagnostic behavior)
Original: Immunohistochemistry#is widely used in#pathology and clinical diagnosis of prostatic carcinoma
#22190
high Confidence
Subject:
Immunohistochemistry
(Histological detection technology)
→
is_widely_used_in
→
Object:
pathology
(Pathology)
Original: Immunohistochemistry#is widely used in#pathology and clinical diagnosis of prostatic carcinoma
#22189
high Confidence
Subject:
perineural_invasion
(Histological characteristics)
→
is_diagnostic_marker_for
→
Object:
carcinoma_cells
(Tumor cells)
Original: features with 100% specificity and PPV#included#cytoplasmic mucin vacuole/ focal gland formation/ and perineural invasion
#22188
high Confidence
Subject:
focal_gland_formation
(Organizational structure characteristics)
→
is_diagnostic_marker_for
→
Object:
carcinoma_cells
(Tumor cells)
Original: features with 100% specificity and PPV#included#cytoplasmic mucin vacuole/ focal gland formation/ and perineural invasion
#22187
high Confidence
Subject:
cytoplasmic_mucin_vacuole
(Cell morphology)
→
is_diagnostic_marker_for
→
Object:
carcinoma_cells
(Tumor cells)
Original: features with 100% specificity and PPV#included#cytoplasmic mucin vacuole/ focal gland formation/ and perineural invasion
#22186
high Confidence
Subject:
Malignant_gastrointestinal_neuroectodermal_tumor
(Tumor diseases)
→
is_associated_with
→
Object:
EWSR1-CREB1_fusion
(Gene fusion)
Original: Malignant gastrointestinal neuroectodermal tumor (MGNET)#is associated with#EWSR1-ATF1/CREB1 fusions
#22185
high Confidence
Subject:
Malignant_gastrointestinal_neuroectodermal_tumor
(Tumor diseases)
→
is_associated_with
→
Object:
EWSR1-ATF1_fusion
(Gene fusion)
Original: Malignant gastrointestinal neuroectodermal tumor (MGNET)#is associated with#EWSR1-ATF1/CREB1 fusions
#22184
high Confidence
Subject:
S100_protein
(protein)
→
was_positive_in
→
Object:
all_cases
(Sample Collection)
Original: S-100 protein#was positive in#all cases
#22183
high Confidence
Subject:
BRAF_rearrangement
(Gene rearrangement)
→
is_targetable_alteration_in
→
Object:
acinar_carcinoma
(Tumor type)
Original: Targetable molecular alterations in acinar carcinoma#include#BRAF rearrangements and DNA repair defects
#22182
high Confidence
Subject:
Rearrangement_of_polymorphous_adenocarcinoma-associated_genes
(Gene rearrangement)
→
was_identified_in
→
Object:
polymorphous_adenocarcinoma_cases
(Adenocarcinoma)
Original: Rearrangement of polymorphous adenocarcinoma-associated genes#was identified in#17 cases (47.2%)
#22181
high Confidence
Subject:
fluorescence_in_situ_hybridization
(Molecular detection technology)
→
detects
→
Object:
gene_splits_in_polymorphous_adenocarcinoma-associated_genes
(Genomic variation)
Original: fluorescence in situ hybridization#was carried out#to detect gene splits in polymorphous adenocarcinoma-associated genes
#22180
high Confidence
Subject:
Rosai-Dorfman_disease
(disease)
→
presents_as
→
Object:
painless_lymphadenopathy
(Clinical symptoms)
Original: Rosai-Dorfman disease (RDD)#presents as#painless lymphadenopathy
#22179
high Confidence
Subject:
neoplastic_cells_in_CSF
(Cytological indicators)
→
is_pivotal_for
→
Object:
management_of_CNS_tumors
(Clinical management)
Original: Detection of neoplastic cells in CSF#is pivotal for#management of CNS tumors
#22178
high Confidence
Subject:
standard_of_care_treatment
(Standard treatment)
→
involves
→
Object:
surgery
(Surgery)
Original: standard-of-care treatment#involves#surgery
#22177
high Confidence
Subject:
Goblet_cells
(Epithelial cells)
→
confirm
→
Object:
Barrett's_esophagus
(disease)
Original: Goblet cells#are present in#all cases/ confirming their utility in defining Barrett's esophagus
#22176
high Confidence
Subject:
gastric_pyloric_gland_adenoma
(Tumor)
→
is
→
Object:
neoplasm_of_gastrointestinal_tract
(Disease phenotype)
Original: Gastric pyloric gland adenoma#is#a neoplasm of the gastrointestinal tract
#22175
high Confidence
Subject:
Fine-needle_aspiration
(Diagnostic techniques)
→
is
→
Object:
predominant_method_for_triaging_thyroid_nodules
(Diagnostic strategy)
Original: Fine-needle aspiration (FNA)#is#the predominant method for triaging thyroid nodules
#22174
high Confidence
Subject:
malignant_tumors
(Tumor)
→
show
→
Object:
distant_metastasis
(Tumor metastasis phenotype)
Original: malignant tumors#show#venous or capsular invasion or distant metastasis
#22173
high Confidence
Subject:
tumor_cells
(Cell Type)
→
expresses
→
Object:
HMB-45
(protein)
Original: tumor cells#expressed#S-100 protein and HMB-45
#22172
high Confidence
Subject:
tumor_cells
(Cell Type)
→
expresses
→
Object:
S-100_protein
(protein)
Original: tumor cells#expressed#S-100 protein and HMB-45
#22171
high Confidence
Subject:
MYCN
(Protein coding genes)
→
is_amplified_in
→
Object:
neuroblastoma
(Tumor type)
Original: MYCN amplification#was confirmed by#fluorescence in situ hybridization
#22170
high Confidence
Subject:
CK20
(Structural proteins)
→
shows_positivity_ratio
→
Object:
lung_cancer
(Tumor type)
Original: Positivity ratios for CK20#are#17.2%/ 15.8%/ 13.5%/ and 32.2% for breast/ ovary/ stomach/ and lung cases respectively
#22169
high Confidence
Subject:
CK20
(Structural proteins)
→
shows_positivity_ratio
→
Object:
stomach_cancer
(Tumor type)
Original: Positivity ratios for CK20#are#17.2%/ 15.8%/ 13.5%/ and 32.2% for breast/ ovary/ stomach/ and lung cases respectively
#22168
high Confidence
Subject:
CK20
(Structural proteins)
→
shows_positivity_ratio
→
Object:
ovarian_cancer
(Tumor type)
Original: Positivity ratios for CK20#are#17.2%/ 15.8%/ 13.5%/ and 32.2% for breast/ ovary/ stomach/ and lung cases respectively
#22167
high Confidence
Subject:
CK20
(Structural proteins)
→
shows_positivity_ratio
→
Object:
breast_cancer
(Tumor type)
Original: Positivity ratios for CK20#are#17.2%/ 15.8%/ 13.5%/ and 32.2% for breast/ ovary/ stomach/ and lung cases respectively
#22166
high Confidence
Subject:
CK7
(Structural proteins)
→
shows_positivity_ratio
→
Object:
lung_cancer
(Tumor type)
Original: Positivity ratios for CK7#are#67.6%/ 63.5%/ 29.7%/ and 45.5% for breast/ ovary/ stomach/ and lung cases respectively
#22165
high Confidence
Subject:
CK7
(Structural proteins)
→
shows_positivity_ratio
→
Object:
stomach_cancer
(Tumor type)
Original: Positivity ratios for CK7#are#67.6%/ 63.5%/ 29.7%/ and 45.5% for breast/ ovary/ stomach/ and lung cases respectively
#22164
high Confidence
Subject:
CK7
(Structural proteins)
→
shows_positivity_ratio
→
Object:
ovarian_cancer
(Tumor type)
Original: Positivity ratios for CK7#are#67.6%/ 63.5%/ 29.7%/ and 45.5% for breast/ ovary/ stomach/ and lung cases respectively
#22163
high Confidence
Subject:
CK7
(Structural proteins)
→
shows_positivity_ratio
→
Object:
breast_cancer
(Tumor type)
Original: Positivity ratios for CK7#are#67.6%/ 63.5%/ 29.7%/ and 45.5% for breast/ ovary/ stomach/ and lung cases respectively
#22162
high Confidence
Subject:
giant_cells
(Tumor cells)
→
are_immunoreactive_for
→
Object:
CD68
(Lysosome-associated membrane proteins)
Original: giant cells#are immunoreactive for#CD68
#22161
high Confidence
Subject:
atypical_cells
(Tumor cells)
→
are_strongly_reactive_for
→
Object:
vimentin
(Intermediate filament protein)
Original: atypical cells#are strongly reactive for#vimentin
#22160
high Confidence
Subject:
Rhabdoid meningioma
(Tumor diseases)
→
is_described_as
→
Object:
aggressive tumor with recurrence risk
(Disease phenotype)
Original: Rhabdoid meningioma#is described as#rare/ WHO Grade III/ aggressive tumor with recurrence risk
#22159
high Confidence
Subject:
Masood_Cytology_Index
(Cytological scoring system)
→
is_used_as
→
Object:
surrogate_biomarker
(Surrogate biomarkers)
Original: Masood Cytology Index#is used as#a surrogate biomarker in chemoprevention trials
#22158
high Confidence
Subject:
9_cases
(Case)
→
were_diagnosed_as
→
Object:
liver_cell_adenoma
(Hepatocellular adenoma)
Original: 99 cases#were diagnosed as#hepatocellular carcinoma and 9 as liver cell adenoma
#22157
high Confidence
Subject:
99_cases
(Case)
→
were_diagnosed_as
→
Object:
hepatocellular_carcinoma
(Hepatocellular carcinoma)
Original: 99 cases#were diagnosed as#hepatocellular carcinoma and 9 as liver cell adenoma
#22156
high Confidence
Subject:
pleomorphic_rhabdomyosarcoma
(Neoplastic diseases)
→
is_a_rare_category_in
→
Object:
children
(Specific populations)
Original: pleomorphic rhabdomyosarcoma#is a rare category in#children
#22155
high Confidence
Subject:
c-myc_amplification
(Gene amplification)
→
is_associated_with
→
Object:
poor_prognosis
(Poor prognosis)
Original: c-myc amplification#is associated with#poor prognosis
#22154
high Confidence
Subject:
t(X;18)_SYT/SSX1_translocation
(Gene translocation)
→
confirms
→
Object:
synovial_sarcoma
(Tumor type)
Original: molecular studies#showed#t(X; 18) SYT/SSX1 translocation confirming SS diagnosis
#22153
high Confidence
Subject:
molecular_studies
(Molecular testing)
→
showed
→
Object:
t(X;18)_SYT/SSX1_translocation
(Gene translocation)
Original: molecular studies#showed#t(X; 18) SYT/SSX1 translocation confirming SS diagnosis
#22152
high Confidence
Subject:
immunophenotypic_findings
(Immunophenotypic characteristics)
→
are_crucial_to
→
Object:
diagnosis_of_HAML
(Diagnostic behavior)
Original: Cognizance of typical cytologic/ histologic/ and immunophenotypic findings#is crucial to#establishing a diagnosis of HAML
#22151
high Confidence
Subject:
histologic_findings
(Histological characteristics)
→
are_crucial_to
→
Object:
diagnosis_of_HAML
(Diagnostic behavior)
Original: Cognizance of typical cytologic/ histologic/ and immunophenotypic findings#is crucial to#establishing a diagnosis of HAML
#22150
high Confidence
Subject:
cytologic_findings
(Cytological characteristics)
→
are_crucial_to
→
Object:
diagnosis_of_HAML
(Diagnostic behavior)
Original: Cognizance of typical cytologic/ histologic/ and immunophenotypic findings#is crucial to#establishing a diagnosis of HAML
#22149
high Confidence
Subject:
ALK_positive_lung_cancer
(Tumor subtype)
→
diagnosed_by
→
Object:
FISH
(Molecular detection technology)
Original: ALK (+) lung cancer#was diagnosed by#fluorescence in situ hybridization (FISH)
#22148
high Confidence
Subject:
Chromosomal_11;22_translocation
(Chromosomal mutations)
→
is_supportive_of
→
Object:
diagnosis_of_extraskeletal_Ewing's_sarcoma
(Diagnosis conclusion)
Original: Chromosomal 11;22 translocation#is supportive of#diagnosis of extraskeletal Ewing's sarcoma
#22147
high Confidence
Subject:
Tumor
(Tumor tissue)
→
was_diagnosed_as
→
Object:
gangliocytoma
(Tumor type)
Original: Tumor#was diagnosed as#gangliocytoma originated from pineal body
#22146
high Confidence
Subject:
next-generation_sequencing
(Detection Technology)
→
revealed
→
Object:
EWSR1-PATZ1_fusion
(Gene fusion)
Original: Next-generation sequencing#revealed#EWSR1-PATZ1 fusion
#22145
high Confidence
Subject:
INI1_protein
(protein)
→
shows
→
Object:
loss_of_nuclear_expression_in_tumor_cell
(Protein expression status)
Original: INI1 protein#showed#a loss of nuclear expression in tumor cells
#22144
high Confidence
Subject:
Melan-A
(Protein markers)
→
is_detected_by
→
Object:
Immunostaining
(Detection Methods)
Original: Tumors#show#immunostaining for S-100/ HMB 45/ and Melan-A
#22143
high Confidence
Subject:
HMB45
(Protein markers)
→
is_detected_by
→
Object:
Immunostaining
(Detection Methods)
Original: Tumors#show#immunostaining for S-100/ HMB 45/ and Melan-A
#22142
high Confidence
Subject:
S100
(Protein markers)
→
is_detected_by
→
Object:
Immunostaining
(Detection Methods)
Original: Tumors#show#immunostaining for S-100/ HMB 45/ and Melan-A
#22141
high Confidence
Subject:
lymphocytes
(Lymphocytes)
→
negative_for
→
Object:
CD3
(Molecular markers)
Original: Lymphocytes#were positive for#CD79a and negative for CD3
#22140
high Confidence
Subject:
lymphocytes
(Lymphocytes)
→
positive_for
→
Object:
CD79a
(Molecular markers)
Original: Lymphocytes#were positive for#CD79a and negative for CD3
#22139
high Confidence
Subject:
SALL4
(Transcription Factors)
→
is
→
Object:
immunocytochemical_marker
(Molecular markers)
Original: SALL4#is#a new immunocytochemical marker
#22138
high Confidence
Subject:
Fine_needle_aspiration_cytology
(Diagnostic techniques)
→
is_used_for
→
Object:
fibrolamellar_hepatocellular_carcinoma
(Hepatocellular carcinoma subtypes)
Original: Fine needle aspiration cytology#is used for#fibrolamellar hepatocellular carcinoma
#22137
high Confidence
Subject:
EWSR1_gene_rearrangement
(Gene rearrangement)
→
is_necessary_for
→
Object:
correct_recognition_of_tumor
(Disease diagnosis)
Original: confirmation of EWSR1 gene rearrangement#is necessary for#correct recognition of the tumor
#22136
high Confidence
Subject:
Wilms_tumor
(Tumor type)
→
is
→
Object:
malignant_renal_neoplasm_in_children
(Tumor type)
Original: Wilms' tumor (WT)#is#the most common malignant renal neoplasm in children
#22135
high Confidence
Subject:
TRAP_assay
(Molecular detection technology)
→
detects
→
Object:
telomerase_activity
(Enzyme activity)
Original: TRAP assay#detects#telomerase activity in tissue specimens
#22134
high Confidence
Subject:
hTERT_protein
(protein)
→
is_localized_by
→
Object:
Immunohistochemistry
(Molecular detection technology)
Original: hTERT protein#is localized by#immunohistochemistry in human tissues
#22133
high Confidence
Subject:
IGLV2-14/IGLL5_fusion
(Gene fusion)
→
is_detected_by
→
Object:
next-generation_sequencing
(Molecular detection technology)
Original: Next-generation sequencing#demonstrated#a novel IGLV2-14/IGLL5 fusion and mutations or deletions in tumor suppressor genes such as PTPRB/ PPP2CB/ and UPK1A
#22132
high Confidence
Subject:
FBL_gene
(Protein coding genes)
→
is_crucial_for
→
Object:
eukaryotic_cells
(Eukaryotic cells)
Original: FBL gene#is crucial for#eukaryotic cells
#22131
high Confidence
Subject:
rDNA
(DNA sequence)
→
encodes
→
Object:
ribosomal_RNA
(rRNA)
Original: NORs (rDNA)#encode#ribosomal RNA
#22130
high Confidence
Subject:
p53
(Transcription Factors)
→
interacts_with
→
Object:
MDM2
(protein)
Original: Interaction with p53 and transcription inhibition#are necessary for#MDM2 function
#22129
high Confidence
Subject:
MDM2
(protein)
→
binds_to
→
Object:
p53
(Transcription Factors)
Original: MDM2 oncoprotein#binds to#p53
#22128
high Confidence
Subject:
NPM1_mutation
(Gene mutation)
→
is_regarded_as
→
Object:
distinct_genetic_entity_in_WHO_classification
(Molecular typing)
Original: NPM1 mutation#is regarded as#a distinct genetic entity in the WHO classification of hematopoietic malignancies
#22127
high Confidence
Subject:
5_fluorouracil
(Small molecule drugs)
→
activates
→
Object:
p53
(Transcription Factors)
Original: 5-fluorouracil#activates#p53 by inducing ribosomal stress
#22126
high Confidence
Subject:
NRG1
(Protein coding genes)
→
is_oncogenic_driver_in
→
Object:
solid_tumors
(Tumor)
Original: NRG1 gene fusions#are#emerging oncogenic drivers in solid tumors
#22125
high Confidence
Subject:
CTLA-4_inhibitor
(Immune checkpoint inhibitors)
→
produces
→
Object:
significant_clinical_response
(Clinical response)
Original: Immunotherapy with PD-1/PD-L1/CTLA-4 inhibitors#produced#significant clinical responses
#22124
high Confidence
Subject:
PD-L1_inhibitor
(Immune checkpoint inhibitors)
→
produces
→
Object:
significant_clinical_response
(Clinical response)
Original: Immunotherapy with PD-1/PD-L1/CTLA-4 inhibitors#produced#significant clinical responses
#22123
high Confidence
Subject:
PD-1_inhibitor
(Immune checkpoint inhibitors)
→
produces
→
Object:
significant_clinical_response
(Clinical response)
Original: Immunotherapy with PD-1/PD-L1/CTLA-4 inhibitors#produced#significant clinical responses
#22122
high Confidence
Subject:
PSF-TFE3_fusion_gene
(Gene fusion products)
→
confirmed_by
→
Object:
reverse_transcription_PCR
(Detection Methods)
Original: PSF-TFE3 fusion genes#were confirmed by#reverse transcription polymerase chain reaction
#22121
high Confidence
Subject:
FH
(Protein coding genes)
→
mutated_in
→
Object:
HLRCC_syndrome
(Rare genetic diseases)
Original: Mutations in FH gene#underlie#HLRCC syndrome
#22120
high Confidence
Subject:
UBF1
(Transcription Factors)
→
interacts_with
→
Object:
rDNA_promoter
(DNA sequence)
Original: UBF1#interacts with#the promoter of rRNA genes (rDNA)
#22119
high Confidence
Subject:
UBF
(Transcription Factors)
→
initiates
→
Object:
rRNA_transcription
(Molecular Process)
Original: Upstream binding factor (UBF)#recognizes#ribosomal RNA gene promoter and initiates transcription
#22118
high Confidence
Subject:
UBF
(Transcription Factors)
→
recognizes
→
Object:
rRNA_gene_promoter
(DNA sequence)
Original: Upstream binding factor (UBF)#recognizes#ribosomal RNA gene promoter and initiates transcription
#22117
high Confidence
Subject:
RPS14
(Ribosomal proteins)
→
inhibits
→
Object:
CDK6
(Kinase)
Original: RPS14#acts as#a CDK4/6 inhibitor linking ribosome biogenesis defects to cell cycle progression
#22116
high Confidence
Subject:
RPS14
(Ribosomal proteins)
→
inhibits
→
Object:
CDK4
(Kinase)
Original: RPS14#acts as#a CDK4/6 inhibitor linking ribosome biogenesis defects to cell cycle progression
#22115
high Confidence
Subject:
Nutlin-3
(Small molecule drugs)
→
activates
→
Object:
p53
(Tumor suppressor proteins)
Original: Nutlin-3#impairs#erythropoiesis by activating p53
#22114
high Confidence
Subject:
TP53
(Tumor suppressor genes)
→
is_involved_in
→
Object:
tumor_suppression
(Tumor suppressor function)
Original: GLTSCR2#is involved in#tumor suppression with p53/ NPM/ and MYC
#22113
high Confidence
Subject:
TP53
(Tumor suppressor genes)
→
acts_as
→
Object:
tumor_suppressor
(Tumor suppressor function)
Original: p14ARF/ARF#acts as#a tumor suppressor through a p53/MDM2-dependent pathway
#22112
high Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar organizing region)
→
are_involved_in
→
Object:
ribosome_synthesis
(Ribosome synthesis process)
Original: nucleolar organizer regions#are involved in#synthesis of ribosomes
#22111
high Confidence
Subject:
hyperactivation_of_ribosome_biogenesis
(Molecular Process)
→
drives
→
Object:
cancer_progression
(Tumor progression)
Original: Hyperactivation of ribosome biogenesis#drives#cancer progression
#22110
high Confidence
Subject:
Breast cancer stem cells
(Cancer stem cells)
→
are_key_players_in
→
Object:
development (tumor progression)
(Tumor progression)
Original: Breast cancer stem cells#are key players in#carcinogenesis and development
#22109
high Confidence
Subject:
Breast cancer stem cells
(Cancer stem cells)
→
are_key_players_in
→
Object:
carcinogenesis
(Tumor development process)
Original: Breast cancer stem cells#are key players in#carcinogenesis and development
#22108
high Confidence
Subject:
DGCR8
(RNA binding proteins)
→
is_necessary_and_sufficient_for
→
Object:
miRNA_biogenesis
(RNA biosynthesis process)
Original: Drosha and DGCR8#are necessary and sufficient for#miRNA biogenesis
#22107
high Confidence
Subject:
Drosha
(Endonuclease)
→
is_necessary_and_sufficient_for
→
Object:
miRNA_biogenesis
(RNA biosynthesis process)
Original: Drosha and DGCR8#are necessary and sufficient for#miRNA biogenesis
#22106
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
is_the_site_of
→
Object:
ribosome_biogenesis
(Molecular Process)
Original: The nucleolus#is the site of#ribosome biogenesis
#22105
high Confidence
Subject:
NOP16
(Ribosomal proteins)
→
promotes
→
Object:
cancer_development
(Tumor development process)
Original: NOP16#promoted#cancer development in LIHC and caused an imbalance in Keap/Nrf2 signaling
#22104
high Confidence
Subject:
NOP16
(Ribosomal proteins)
→
is_upregulated_in
→
Object:
LIHC
(disease)
Original: Pan-cancer analysis#revealed#high NOP16 expression in 20 cancer types/ including LIHC
#22103
high Confidence
Subject:
HPD
(protein)
→
inversely_correlates_with
→
Object:
overall_survival
(Survival Outcome)
Original: HPD expression level#is inversely correlated with#10-year overall survival rates in breast cancer
#22102
high Confidence
Subject:
TP53
(Tumor suppressor proteins)
→
is_silenced_in
→
Object:
gastric_adenocarcinoma
(disease)
Original: staining for TP53 overexpression#was negative in#gastric adenocarcinoma
#22101
high Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar organizer region)
→
are_situated_on
→
Object:
short_arms_of_acrocentric_chromosomes
(Chromosome short arm)
Original: Nucleolar organizer regions (NORs)#are situated on#short arms of acrocentric chromosomes 13/ 14/ 15/ 21/ and 22
#22100
high Confidence
Subject:
fasciitis_ossificans
(Fasciitis ossificans)
→
needs_to_be_considered_in
→
Object:
differential_diagnosis
(Differential Diagnosis)
Original: Fasciitis ossificans#needs to be considered in#the differential diagnosis of breast hard tumor
#22099
high Confidence
Subject:
two_cases
(Two cases)
→
were_revised_to
→
Object:
malignant_lymphoma
(Malignant lymphoma)
Original: Two cases#were revised to#malignant lymphoma
#22098
high Confidence
Subject:
nodule
(Nodules)
→
had
→
Object:
thin_fibrous_capsule
(Thin fiber coating)
Original: nodule#was#resiliently firm/ pale gray/ with large central fibrosis and thin fibrous capsule
#22097
high Confidence
Subject:
nodule
(Nodules)
→
had
→
Object:
central_fibrosis
(Central fibrosis)
Original: nodule#was#resiliently firm/ pale gray/ with large central fibrosis and thin fibrous capsule
#22096
high Confidence
Subject:
nodule
(Nodules)
→
was
→
Object:
pale_gray
(Off-white)
Original: nodule#was#resiliently firm/ pale gray/ with large central fibrosis and thin fibrous capsule
#22095
high Confidence
Subject:
nodule
(Nodules)
→
was
→
Object:
resiliently_firm
(Tough texture)
Original: nodule#was#resiliently firm/ pale gray/ with large central fibrosis and thin fibrous capsule
#22094
high Confidence
Subject:
serum_NSE_level
(Serum NSE level)
→
is_useful_index_for
→
Object:
monitoring_treatment
(Treatment monitoring)
Original: Serum NSE level#is a useful index for#monitoring treatment of leiomyosarcoma
#22093
high Confidence
Subject:
cases
(Case)
→
showed
→
Object:
polygonal_cells
(Polygonal cells)
Original: cases#showed#fascicles of slightly spindled and polygonal cells
#22092
high Confidence
Subject:
cases
(Case)
→
showed
→
Object:
fascicles_of_spindled_cells
(Spindle cell bundle)
Original: cases#showed#fascicles of slightly spindled and polygonal cells
#22091
high Confidence
Subject:
pure_LELC_tumor
(Pure lymphoepithelioid carcinoma)
→
appears_to_be
→
Object:
clinically_different
(Clinical Differences)
Original: pure LELC tumor#appears to be#clinically different from TCC
#22090
high Confidence
Subject:
pure_LELC_tumors
(Pure lymphoepithelioid carcinoma)
→
did_not_have
→
Object:
TCC_in_situ
(Metastatic cell carcinoma in situ)
Original: three pure LELC tumors#did not have#concurrent invasive transitional-cell carcinoma or TCC in situ
#22089
high Confidence
Subject:
pure_LELC_tumors
(Pure lymphoepithelioid carcinoma)
→
did_not_have
→
Object:
concurrent_invasive_transitional_cell_carcinoma
(Concurrent invasive transitional cell carcinoma)
Original: three pure LELC tumors#did not have#concurrent invasive transitional-cell carcinoma or TCC in situ
#22088
high Confidence
Subject:
SGCs_area
(syncytial giant cell region)
→
was_noted_in
→
Object:
clear_cell_renal_cell_carcinoma_background
(Background of Clear Cell Renal Cell Carcinoma)
Original: microscopically/ a 1.8-cm area of SGCs#was noted in#background of clear cell renal cell carcinoma
#22087
high Confidence
Subject:
renal_cell_carcinoma_with_syncytial_giant_cells
(Syncytial giant cell renal cell carcinoma)
→
is
→
Object:
rare
(rare)
Original: renal cell carcinoma#with syncytial giant cells#is rare
#22086
high Confidence
Subject:
small_cell_carcinoma
(Small cell carcinoma)
→
was_characterized_by
→
Object:
cohesive_clusters
(Adhesive clumps)
Original: Small cell carcinoma#was characterized by#cohesive clusters of small round cells with round to oval nuclei and scant cytoplasm
#22085
high Confidence
Subject:
chromosome_aberration_test
(Chromosome aberration test)
→
revealed
→
Object:
neutral_rearrangements
(Neutral rearrangement)
Original: Chromosome aberration test#revealed#presence of structural aberration/ numerical and neutral rearrangements
#22084
high Confidence
Subject:
chromosome_aberration_test
(Chromosome aberration test)
→
revealed
→
Object:
numerical_rearrangements
(Number Rearrangement)
Original: Chromosome aberration test#revealed#presence of structural aberration/ numerical and neutral rearrangements
#22083
high Confidence
Subject:
chromosome_aberration_test
(Chromosome aberration test)
→
revealed
→
Object:
structural_aberration
(Structural distortion)
Original: Chromosome aberration test#revealed#presence of structural aberration/ numerical and neutral rearrangements
#22082
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
exhibit
→
Object:
cytoplasmic_vacuolization
(Cytoplasmic vacuolization)
Original: Tumor cells#exhibit#eccentric nuclei/ prominent nucleoli/ and occasional cytoplasmic vacuolization
#22081
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
exhibit
→
Object:
prominent_nucleoli
(Obvious nucleolus)
Original: Tumor cells#exhibit#eccentric nuclei/ prominent nucleoli/ and occasional cytoplasmic vacuolization
#22080
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
exhibit
→
Object:
eccentric_nuclei
(Eccentric core)
Original: Tumor cells#exhibit#eccentric nuclei/ prominent nucleoli/ and occasional cytoplasmic vacuolization
#22079
high Confidence
Subject:
mass
(Lump)
→
yielded
→
Object:
focal_necrosis
(Focal necrosis)
Original: Mass#yielded#monomorphic/ moderately atypical cells/ both single and clustered/ associated with abundant mucoid material and focal necrosis
#22078
high Confidence
Subject:
mass
(Lump)
→
yielded
→
Object:
mucoid_material
(Mucous substances)
Original: Mass#yielded#monomorphic/ moderately atypical cells/ both single and clustered/ associated with abundant mucoid material and focal necrosis
#22077
high Confidence
Subject:
mass
(Lump)
→
yielded
→
Object:
monomorphic_atypical_cells
(Monomorphic atypical cells)
Original: Mass#yielded#monomorphic/ moderately atypical cells/ both single and clustered/ associated with abundant mucoid material and focal necrosis
#22076
high Confidence
Subject:
AMFH
(Angiomalignant fibrous histiocytoma)
→
affects_mostly
→
Object:
young_adults
(teenager)
Original: AMFH#affects mostly#extremities of children and young adults
#22075
high Confidence
Subject:
AMFH
(Angiomalignant fibrous histiocytoma)
→
affects_mostly
→
Object:
children
(child)
Original: AMFH#affects mostly#extremities of children and young adults
#22074
high Confidence
Subject:
AMFH
(Angiomalignant fibrous histiocytoma)
→
affects_mostly
→
Object:
extremities
(Limbs)
Original: AMFH#affects mostly#extremities of children and young adults
#22073
high Confidence
Subject:
cytological_diagnosis_of_UPSC
(Diagnosis of serous carcinoma)
→
should_be_based_on
→
Object:
papillary_clusters
(Papillary masses)
Original: Cytological diagnosis of UPSC#should be based on#tumor diathesis/ psammoma bodies/ and papillary clusters
#22072
high Confidence
Subject:
cytological_diagnosis_of_UPSC
(Diagnosis of serous carcinoma)
→
should_be_based_on
→
Object:
psammoma_bodies
(Gravel)
Original: Cytological diagnosis of UPSC#should be based on#tumor diathesis/ psammoma bodies/ and papillary clusters
#22071
high Confidence
Subject:
cytological_diagnosis_of_UPSC
(Diagnosis of serous carcinoma)
→
should_be_based_on
→
Object:
tumor_diathesis
(Tumor necrosis background)
Original: Cytological diagnosis of UPSC#should be based on#tumor diathesis/ psammoma bodies/ and papillary clusters
#22070
high Confidence
Subject:
infiltrates
(Infiltrating cells)
→
include
→
Object:
atypical_lymphocytes
(Atypical lymphocytes)
Original: Infiltrates#comprise#small-to-medium-sized atypical lymphocytes with inconspicuous nucleoli
#22069
high Confidence
Subject:
nucleoli_presence
(Nucleolus exists)
→
distinguishes
→
Object:
AH
(Dysplasia)
Original: Presence of nucleoli#distinguishes#hyperplasia without atypia versus AH
#22068
high Confidence
Subject:
nucleoli_presence
(Nucleolus exists)
→
distinguishes
→
Object:
hyperplasia_without_atypia
(No dysplasia)
Original: Presence of nucleoli#distinguishes#hyperplasia without atypia versus AH
#22067
high Confidence
Subject:
squamous_metaplasia
(Squamous metaplasia)
→
were_observed_based_on
→
Object:
squamous_metaplastic_cells
(Squamous metaplastic cells)
Original: Four degrees of squamous metaplasia#were observed based on#squamous metaplastic cells versus benign/malignant epithelial cells
#22066
high Confidence
Subject:
clinical_management
(Clinical management)
→
includes
→
Object:
adequate_sampling
(Adequate sampling)
Original: Clinical management#includes#adequate sampling of the lesion
#22065
high Confidence
Subject:
2;17_translocation
(Chromosomal translocation)
→
results_in
→
Object:
CLTC-ALK_fusion
(Gene fusion)
Original: 2;17 translocation#resulted in#fusion of CLTC gene with ALK
#22064
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_strongly_positive_for
→
Object:
IGF_II
(Growth Factors)
Original: neoplastic cells#were strongly positive for#chromogranin A/ neuron-specific enolase/ synaptophysin/ and IGF-II
#22063
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_strongly_positive_for
→
Object:
synaptophysin
(Synaptic proteins)
Original: neoplastic cells#were strongly positive for#chromogranin A/ neuron-specific enolase/ synaptophysin/ and IGF-II
#22062
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_strongly_positive_for
→
Object:
neuron_specific_enolase
(Enzymes)
Original: neoplastic cells#were strongly positive for#chromogranin A/ neuron-specific enolase/ synaptophysin/ and IGF-II
#22061
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_strongly_positive_for
→
Object:
chromogranin_A
(Secretory proteins)
Original: neoplastic cells#were strongly positive for#chromogranin A/ neuron-specific enolase/ synaptophysin/ and IGF-II
#22060
high Confidence
Subject:
EGFR_mutation
(Gene mutation)
→
detected_in
→
Object:
colon_cancer
(Tumor)
Original: Mutations#detected in#APC/ TP53/ RB1/ FBWX7/ RET/ EGFR/ FLT3
#22059
high Confidence
Subject:
TP53_mutation
(Gene mutation)
→
detected_in
→
Object:
colon_cancer
(Tumor)
Original: Mutations#detected in#APC/ TP53/ RB1/ FBWX7/ RET/ EGFR/ FLT3
#22058
high Confidence
Subject:
APC_mutation
(Gene mutation)
→
detected_in
→
Object:
colon_cancer
(Tumor)
Original: Mutations#detected in#APC/ TP53/ RB1/ FBWX7/ RET/ EGFR/ FLT3
#22057
high Confidence
Subject:
breast_carcinoma
(Tumor tissue)
→
were_assigned
→
Object:
tumor_grade
(Histological grading)
Original: fifty cases of breast carcinoma#were assigned#tumor grade
#22056
high Confidence
Subject:
histological_grading
(Histological grading)
→
was_done_according_to
→
Object:
Nottingham_modification_of_Scarff-Bloom-Richardson_method
(Grading method)
Original: histological grading#was done according to#Nottingham modification of Scarff-Bloom-Richardson method
#22055
high Confidence
Subject:
complete_surgical_excision
(Treatment procedures)
→
provides
→
Object:
disease-free_survival
(Clinical Outcomes)
Original: complete surgical excision#provides#the best chance for disease-free survival
#22054
high Confidence
Subject:
patient
(patient)
→
was_diagnosed_as
→
Object:
variant_hairy_cell_leukemia
(Rare leukemia subtypes)
Original: The patient#was diagnosed as#a case of variant hairy cell leukemia
#22053
high Confidence
Subject:
tumor
(Solid tumors)
→
tends_to_be
→
Object:
high_grade_with_lymphovascular_invasion
(Tumor Biological Characteristics)
Original: tumor#tends to be#high grade with lymphovascular invasion
#22052
high Confidence
Subject:
tumor
(Solid tumors)
→
is_usually
→
Object:
poorly_differentiated_with_deep_myometrial_invasion
(Tumor Biological Characteristics)
Original: tumor#is usually#poorly differentiated with deep myometrial invasion
#22051
high Confidence
Subject:
Sebaceous_adenoma
(Adenoma)
→
is
→
Object:
rare_benign_neoplasm_of_salivary_gland
(Tumor Biological Characteristics)
Original: Sebaceous adenoma#is#a rare/ benign neoplasm of the salivary gland
#22050
high Confidence
Subject:
Solid pseudopapillary tumor (SPT)
(Solid tumors)
→
is_associated_with
→
Object:
long_patient_survival
(Clinical Outcomes)
Original: tumor#is associated with#long patient survival even with organ extension and metastases
#22049
high Confidence
Subject:
Solid pseudopapillary tumor (SPT)
(Solid tumors)
→
is
→
Object:
indolent
(Tumor Biological Characteristics)
Original: tumor#is#indolent
#22048
high Confidence
Subject:
Epstein-Barr_virus_infection
(Viral infection)
→
is_strongly_associated_with
→
Object:
Nonkeratinizing_nasopharyngeal_carcinoma
(Malignant tumors)
Original: Nonkeratinizing NPC#is strongly associated with#prior Epstein-Barr virus (EBV) infection
#22047
high Confidence
Subject:
Nasopharyngeal_carcinoma
(Malignant tumors)
→
is_classified_as
→
Object:
Undifferentiated_carcinoma
(Histopathological type)
Original: Nasopharyngeal carcinoma (NPC)#is classified as#3 main types by WHO
#22046
high Confidence
Subject:
Nasopharyngeal_carcinoma
(Malignant tumors)
→
is_classified_as
→
Object:
Nonkeratinizing_carcinoma_differentiated
(Histopathological type)
Original: Nasopharyngeal carcinoma (NPC)#is classified as#3 main types by WHO
#22045
high Confidence
Subject:
Nasopharyngeal_carcinoma
(Malignant tumors)
→
is_classified_as
→
Object:
Keratinizing_squamous_cell_carcinoma
(Histopathological type)
Original: Nasopharyngeal carcinoma (NPC)#is classified as#3 main types by WHO
#22044
high Confidence
Subject:
three_significant_signs
(Clinical signs)
→
indicates
→
Object:
prostatic_duct_adenocarcinoma
(Prostatic ductal adenocarcinoma)
Original: Three significant signs and any additional signs#indicated#100% probability of PDAC
#22043
high Confidence
Subject:
histologic_section
(Tissue sections)
→
shows
→
Object:
mucinous_adenocarcinoma
(Mucinous adenocarcinoma)
Original: Histologic sections#showed#mucinous adenocarcinoma
#22042
high Confidence
Subject:
surgery
(Surgery)
→
removes
→
Object:
cystic_calculi
(Disease phenotype)
Original: Surgery#was done to remove#cystic calculi
#22041
high Confidence
Subject:
polymorphous_adenocarcinoma
(Tumor type)
→
is
→
Object:
minor_salivary_gland_carcinoma
(Tumor type)
Original: Polymorphous adenocarcinoma#is#a common intraoral minor salivary gland carcinoma in Western countries
#22040
high Confidence
Subject:
findings
(Clinical examination)
→
are_consistent_with
→
Object:
malignant_melanoma
(Disease phenotype)
Original: Findings#are consistent with#a diagnosis of malignant melanoma
#22039
high Confidence
Subject:
radical_resection_postoperative_radiotherapy
(Treatment options)
→
is_treatment_of_choice_for
→
Object:
oncocytic_carcinoma
(Tumor type)
Original: Radical resection postoperative radiotherapy#is#the treatment of choice for oncocytic carcinoma
#22038
high Confidence
Subject:
PET/CT_imaging
(Imaging technology)
→
demonstrates
→
Object:
splenic_mass
(Imaging findings)
Original: PET/CT imaging#demonstrates#hypermetabolic lymph nodes in neck/ abdomen/ thorax/ pelvis/ pulmonary nodules/ and a splenic mass
#22037
high Confidence
Subject:
PET/CT_imaging
(Imaging technology)
→
demonstrates
→
Object:
pulmonary_nodules
(Imaging findings)
Original: PET/CT imaging#demonstrates#hypermetabolic lymph nodes in neck/ abdomen/ thorax/ pelvis/ pulmonary nodules/ and a splenic mass
#22036
high Confidence
Subject:
PET/CT_imaging
(Imaging technology)
→
demonstrates
→
Object:
hypermetabolic_lymph_nodes
(Imaging findings)
Original: PET/CT imaging#demonstrates#hypermetabolic lymph nodes in neck/ abdomen/ thorax/ pelvis/ pulmonary nodules/ and a splenic mass
#22035
high Confidence
Subject:
Direct_sampling_of_cells_from_uterine_cavity
(Diagnostic techniques)
→
is_essential_for
→
Object:
detection_of_endometrial_carcinoma
(Diagnostic Process)
Original: Direct sampling of cells from the uterine cavity#is essential for#the detection of endometrial carcinoma
#22034
high Confidence
Subject:
fine-needle_aspiration_cytology
(Diagnostic techniques)
→
distinguishes
→
Object:
follicular_variant_of_papillary_carcinoma_of_the_thyroid
(Thyroid tumor subtypes)
Original: Fine-needle aspiration cytology diagnosis#distinguishes#colloid nodule from follicular variant of papillary carcinoma of the thyroid
#22033
high Confidence
Subject:
fine-needle_aspiration_cytology
(Diagnostic techniques)
→
distinguishes
→
Object:
colloid_nodule
(Thyroid nodules)
Original: Fine-needle aspiration cytology diagnosis#distinguishes#colloid nodule from follicular variant of papillary carcinoma of the thyroid
#22032
high Confidence
Subject:
AMACR
(Protein markers)
→
is_used_in
→
Object:
partial_atrophy_cases
(Pathological cases)
Original: A triple cocktail stain [p63/ HMWCK/ AMACR]#was used for#partial atrophy cases
#22031
high Confidence
Subject:
HMWCK
(Protein markers)
→
is_used_in
→
Object:
partial_atrophy_cases
(Pathological cases)
Original: A triple cocktail stain [p63/ HMWCK/ AMACR]#was used for#partial atrophy cases
#22030
high Confidence
Subject:
p63
(Protein markers)
→
is_used_in
→
Object:
partial_atrophy_cases
(Pathological cases)
Original: A triple cocktail stain [p63/ HMWCK/ AMACR]#was used for#partial atrophy cases
#22029
high Confidence
Subject:
UCHL-1
(T cell surface molecules)
→
is_expressed_on
→
Object:
T_cells
(Immune cells)
Original: Immunohistochemical stains#demonstrated#expression of the T-cell markers CD3 and UCHL-1
#22028
high Confidence
Subject:
CD3
(T cell surface molecules)
→
is_expressed_on
→
Object:
T_cells
(Immune cells)
Original: Immunohistochemical stains#demonstrated#expression of the T-cell markers CD3 and UCHL-1
#22027
high Confidence
Subject:
Non-Hodgkin's_lymphoma
(Tumor diseases)
→
is_a
→
Object:
lymphoid_tumor
(Tumor diseases)
Original: Non-Hodgkin's lymphomas#represent#a heterogeneous group of lymphoid tumors with different morphological/ clinical/ and immunophenotypic features
#22026
high Confidence
Subject:
T_cell_receptor_gamma_gene_rearrangement
(Gene rearrangement)
→
is
→
Object:
monoclonal
(Clone Status)
Original: T-cell receptor �?gene rearrangement#is#monoclonal
#22025
high Confidence
Subject:
patient
(patient)
→
was_diagnosed_with
→
Object:
prostatic_adenocarcinoma_Gleason_3_3_6
(Tumor grade)
Original: two patients#were diagnosed with#prostatic adenocarcinoma Gleason grade 3+3=6
#22024
high Confidence
Subject:
cases
(Case)
→
showed
→
Object:
malignant_transformation
(Tumor progression)
Original: None of the cases#showed#malignant transformation to date
#22023
high Confidence
Subject:
Non-sebaceous_lymphadenoma
(Tumor type)
→
is
→
Object:
benign_tumor_of_salivary_glands
(Tumor phenotype)
Original: Non-sebaceous lymphadenoma#is#a benign tumor of salivary glands
#22022
high Confidence
Subject:
patient
(patient)
→
underwent
→
Object:
postoperative_left_vulvar_irradiation
(Radiation therapy)
Original: Patient#underwent#a left radical vulvectomy with bilateral inguinal and pelvic lymphadenectomy and postoperative left vulvar irradiation
#22021
high Confidence
Subject:
patient
(patient)
→
underwent
→
Object:
pelvic_lymphadenectomy
(Surgery)
Original: Patient#underwent#a left radical vulvectomy with bilateral inguinal and pelvic lymphadenectomy and postoperative left vulvar irradiation
#22020
high Confidence
Subject:
patient
(patient)
→
underwent
→
Object:
bilateral_inguinal_lymphadenectomy
(Surgery)
Original: Patient#underwent#a left radical vulvectomy with bilateral inguinal and pelvic lymphadenectomy and postoperative left vulvar irradiation
#22019
high Confidence
Subject:
patient
(patient)
→
underwent
→
Object:
left_radical_vulvectomy
(Surgery)
Original: Patient#underwent#a left radical vulvectomy with bilateral inguinal and pelvic lymphadenectomy and postoperative left vulvar irradiation
#22018
high Confidence
Subject:
midline_carcinoma
(Tumor type)
→
is_diagnosed_in
→
Object:
upper_aerodigestive_tract
(Anatomical location)
Original: Midline carcinomas#are diagnosed in#head/ neck/ mediastinum/ and upper aerodigestive tract
#22017
high Confidence
Subject:
midline_carcinoma
(Tumor type)
→
is_diagnosed_in
→
Object:
mediastinum
(Anatomical location)
Original: Midline carcinomas#are diagnosed in#head/ neck/ mediastinum/ and upper aerodigestive tract
#22016
high Confidence
Subject:
midline_carcinoma
(Tumor type)
→
is_diagnosed_in
→
Object:
neck
(Anatomical location)
Original: Midline carcinomas#are diagnosed in#head/ neck/ mediastinum/ and upper aerodigestive tract
#22015
high Confidence
Subject:
midline_carcinoma
(Tumor type)
→
is_diagnosed_in
→
Object:
head
(Anatomical location)
Original: Midline carcinomas#are diagnosed in#head/ neck/ mediastinum/ and upper aerodigestive tract
#22014
high Confidence
Subject:
sex_cord_cell
(Cell Type)
→
is_positive_for
→
Object:
calretinin
(Protein markers)
Original: Sex cord cells#were small with#dense/ oval or angulated nuclei/ inconspicuous nucleoli/ and positivity for inhibin/ FOXL2/ SF1/ SOX9/ WT1/ and calretinin
#22013
high Confidence
Subject:
sex_cord_cell
(Cell Type)
→
is_positive_for
→
Object:
WT1
(Transcription Factors)
Original: Sex cord cells#were small with#dense/ oval or angulated nuclei/ inconspicuous nucleoli/ and positivity for inhibin/ FOXL2/ SF1/ SOX9/ WT1/ and calretinin
#22012
high Confidence
Subject:
sex_cord_cell
(Cell Type)
→
is_positive_for
→
Object:
SOX9
(Transcription Factors)
Original: Sex cord cells#were small with#dense/ oval or angulated nuclei/ inconspicuous nucleoli/ and positivity for inhibin/ FOXL2/ SF1/ SOX9/ WT1/ and calretinin
#22011
high Confidence
Subject:
sex_cord_cell
(Cell Type)
→
is_positive_for
→
Object:
SF1
(Transcription Factors)
Original: Sex cord cells#were small with#dense/ oval or angulated nuclei/ inconspicuous nucleoli/ and positivity for inhibin/ FOXL2/ SF1/ SOX9/ WT1/ and calretinin
#22010
high Confidence
Subject:
sex_cord_cell
(Cell Type)
→
is_positive_for
→
Object:
FOXL2
(Transcription Factors)
Original: Sex cord cells#were small with#dense/ oval or angulated nuclei/ inconspicuous nucleoli/ and positivity for inhibin/ FOXL2/ SF1/ SOX9/ WT1/ and calretinin
#22009
high Confidence
Subject:
sex_cord_cell
(Cell Type)
→
is_positive_for
→
Object:
inhibin
(Protein markers)
Original: Sex cord cells#were small with#dense/ oval or angulated nuclei/ inconspicuous nucleoli/ and positivity for inhibin/ FOXL2/ SF1/ SOX9/ WT1/ and calretinin
#22008
high Confidence
Subject:
Tumor
(Tumor)
→
was_diagnosed_as
→
Object:
myoepithelial_carcinoma
(Tumor type)
Original: Tumor#was diagnosed as#a myoepithelial carcinoma with focal rhabdoid features
#22007
high Confidence
Subject:
mTORC1
(Protein complex)
→
upregulates
→
Object:
transcription_of_ribosomal_RNA
(Transcription process)
Original: mTORC1#positively regulates#transcription of ribosomal RNA
#22006
high Confidence
Subject:
nucleolus
(Organelles)
→
plays_key_role_in
→
Object:
ribosome_biogenesis
(Molecular Process)
Original: nucleolus#is#a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis
#22005
high Confidence
Subject:
nucleolus
(Organelles)
→
plays_key_role_in
→
Object:
rRNA_synthesis
(Molecular Process)
Original: nucleolus#is#a subnuclear compartment with key roles in rRNA synthesis and ribosome biogenesis
#22004
high Confidence
Subject:
LATS_kinases
(Protein kinase)
→
phosphorylation
→
Object:
YAP
(Transcription coactivator)
Original: activation of Hippo pathway#restricts#YAP nuclear entry via phosphorylation by Lats kinases
#22003
high Confidence
Subject:
ribosomal_DNA
(DNA sequence)
→
is_bound_to
→
Object:
histones
(Histone)
Original: Ribosomal DNA#is bound to#histones
#22002
high Confidence
Subject:
Gastric_cancer
(Tumor type)
→
holds
→
Object:
second_leading_cause_of_cancer_death
(Epidemiological characteristics)
Original: Gastric cancer#holds#the position of the second leading cause of cancer-related deaths
#22001
high Confidence
Subject:
Gastric_cancer
(Tumor type)
→
is
→
Object:
one_of_the_most_prevalent_cancer_types
(Epidemiological characteristics)
Original: Gastric cancer#is#one of the most prevalent cancer types worldwide
#22000
high Confidence
Subject:
EGFR_expression
(Protein expression)
→
is_significantly_associated_with
→
Object:
axillary_lymph_node_metastases
(Tumor metastasis)
Original: EGFR expression#is significantly associated with#axillary lymph node metastases
#21999
high Confidence
Subject:
Lymphatic_infiltration
(Tissue Microenvironment)
→
predictions
→
Object:
survival
(Survival Outcome)
Original: Lymphatic infiltration (LI)#predicts#survival in prostatic adenocarcinoma
#21998
high Confidence
Subject:
AgNOR_proteins
(Nucleolar Organizer Region Protein)
→
are_stained_by
→
Object:
modified_silver_staining
(Dyeing technology)
Original: AgNOR proteins#were stained by#a modified silver staining technique
#21997
high Confidence
Subject:
ERBB2
(Receptor tyrosine kinases)
→
is_observed_in
→
Object:
malignant_tumors
(Malignant tumors)
Original: c-erbB-2 oncoprotein#was observed in#malignant tumors
#21996
high Confidence
Subject:
CD105
(Membrane Protein)
→
highlights
→
Object:
microvessel_density
(Microvessel density)
Original: Microvessel density (MVD) highlighted by Endoglin (CD105)#was counted by#a standard protocol
#21995
high Confidence
Subject:
TP53
(Tumor suppressor proteins)
→
was_investigated_by
→
Object:
Immunohistochemistry
(Experimental techniques)
Original: Expressions of Endoglin (CD105)/ VEGF/ and p53#were investigated by#immunohistochemistry
#21994
high Confidence
Subject:
VEGF
(Growth Factors)
→
was_investigated_by
→
Object:
Immunohistochemistry
(Experimental techniques)
Original: Expressions of Endoglin (CD105)/ VEGF/ and p53#were investigated by#immunohistochemistry
#21993
high Confidence
Subject:
CD105
(Membrane Protein)
→
was_investigated_by
→
Object:
Immunohistochemistry
(Experimental techniques)
Original: Expressions of Endoglin (CD105)/ VEGF/ and p53#were investigated by#immunohistochemistry
#21992
high Confidence
Subject:
proliferative_markers
(Molecular markers)
→
establishes
→
Object:
prognosis_in_cancer_followup
(Prognosis)
Original: Expression of proliferative markers#establishes#a prognosis in cancer follow-up
#21991
high Confidence
Subject:
Biopsy_material
(Biological samples)
→
is_embedded_in
→
Object:
paraffin
(Embedding agent)
Original: Biopsy material#is fixed in#formol and embedded in paraffin
#21990
high Confidence
Subject:
Biopsy_material
(Biological samples)
→
is_fixed_in
→
Object:
formol
(Fixative)
Original: Biopsy material#is fixed in#formol and embedded in paraffin
#21989
high Confidence
Subject:
nucleolar_hTERT
(Telomerase reverse transcriptase)
→
correlates_with
→
Object:
malignancy_progression
(Tumor progression)
Original: Nucleolar or subnuclear hTERT#correlates directly with#recurrence and malignancy progression
#21988
high Confidence
Subject:
nucleolar_hTERT
(Telomerase reverse transcriptase)
→
correlates_with
→
Object:
recurrence
(Disease recurrence)
Original: Nucleolar or subnuclear hTERT#correlates directly with#recurrence and malignancy progression
#21987
high Confidence
Subject:
excisional_biopsy
(Diagnostic Operations)
→
was_performed_on
→
Object:
lesion
(Diseased tissue)
Original: Excisional biopsy#was performed on#a lesion
#21986
high Confidence
Subject:
surgical_excision
(Treatment)
→
is_recommended_for
→
Object:
tumor-free_margins
(Treatment goals)
Original: surgical excision#is recommended for#tumor-free margins and prolonged follow-up
#21985
high Confidence
Subject:
FISH analysis
(Detection Methods)
→
showed_presence_of
→
Object:
FUS-TFCP2_fusion
(Gene fusion)
Original: FISH analysis#showed presence of#FUS-TFCP2 fusion
#21984
high Confidence
Subject:
intraosseous_rhabdomyosarcoma
(Tumor subtype)
→
is
→
Object:
rare_aggressive_subtype
(Disease characteristics)
Original: intraosseous rhabdomyosarcoma#is#a rare aggressive subtype with predilection for gnathic bones
#21983
high Confidence
Subject:
immunohistochemistry_for_pan-TRK
(Diagnostic Tests)
→
can_be_used_for
→
Object:
screening_for_fusion_proteins
(Molecular screening)
Original: Immunohistochemistry for ALK/ ROS1/ pan-TRK#can be used for#screening purposes to detect fusion proteins
#21982
high Confidence
Subject:
immunohistochemistry_for_ROS1
(Diagnostic Tests)
→
can_be_used_for
→
Object:
screening_for_fusion_proteins
(Molecular screening)
Original: Immunohistochemistry for ALK/ ROS1/ pan-TRK#can be used for#screening purposes to detect fusion proteins
#21981
high Confidence
Subject:
immunohistochemistry_for_ALK
(Diagnostic Tests)
→
can_be_used_for
→
Object:
screening_for_fusion_proteins
(Molecular screening)
Original: Immunohistochemistry for ALK/ ROS1/ pan-TRK#can be used for#screening purposes to detect fusion proteins
#21980
high Confidence
Subject:
proliferating_cells
(Cell Type)
→
lack_expression_of
→
Object:
carcinoembryonic_antigen
(protein)
Original: proliferating cells#were negative for#cytokeratin/ epithelial membrane antigen/ CD15/ CD30/ melan A/ and carcinoembryonic antigen
#21979
high Confidence
Subject:
proliferating_cells
(Cell Type)
→
lack_expression_of
→
Object:
melan_A
(protein)
Original: proliferating cells#were negative for#cytokeratin/ epithelial membrane antigen/ CD15/ CD30/ melan A/ and carcinoembryonic antigen
#21978
high Confidence
Subject:
proliferating_cells
(Cell Type)
→
lack_expression_of
→
Object:
CD30
(Cell surface molecules)
Original: proliferating cells#were negative for#cytokeratin/ epithelial membrane antigen/ CD15/ CD30/ melan A/ and carcinoembryonic antigen
#21977
high Confidence
Subject:
proliferating_cells
(Cell Type)
→
lack_expression_of
→
Object:
CD15
(Cell surface molecules)
Original: proliferating cells#were negative for#cytokeratin/ epithelial membrane antigen/ CD15/ CD30/ melan A/ and carcinoembryonic antigen
#21976
high Confidence
Subject:
proliferating_cells
(Cell Type)
→
lack_expression_of
→
Object:
epithelial_membrane_antigen
(protein)
Original: proliferating cells#were negative for#cytokeratin/ epithelial membrane antigen/ CD15/ CD30/ melan A/ and carcinoembryonic antigen
#21975
high Confidence
Subject:
proliferating_cells
(Cell Type)
→
lack_expression_of
→
Object:
cytokeratin
(protein)
Original: proliferating cells#were negative for#cytokeratin/ epithelial membrane antigen/ CD15/ CD30/ melan A/ and carcinoembryonic antigen
#21974
high Confidence
Subject:
Malignant_melanotic_nerve_sheath_tumor_(MMNST)
(Tumor)
→
originates_from
→
Object:
Schwann_cells
(Cell Type)
Original: Malignant melanotic nerve sheath tumor (MMNST)#originates from#Schwann cells
#21973
high Confidence
Subject:
Merkel_cell_carcinoma
(Malignant tumors)
→
harbors
→
Object:
Merkel_cell_polyomavirus
(Virus)
Original: Merkel cell carcinoma (MCC)#harbors#Merkel cell polyomavirus (MCPyV) in the majority of cases
#21972
high Confidence
Subject:
Neoplasm
(Tumor)
→
is_composed_of
→
Object:
small_cells_with_rhabdoid_morphology
(Tumor cell phenotype)
Original: Neoplasm#is composed of#small/medium cells with rhabdoid morphology
#21971
high Confidence
Subject:
Endothelial_cells
(Endothelial cells)
→
contain
→
Object:
pinocytotic_vesicles
(Pinocytotic vesicles)
Original: Endothelial cells#contain#pinocytotic vesicles
#21970
high Confidence
Subject:
Endothelial_cells
(Endothelial cells)
→
contain
→
Object:
cytoplasmic_filaments
(Cytoplasmic filaments)
Original: Endothelial cells#contain#cytoplasmic filaments
#21969
high Confidence
Subject:
Endothelial_cells
(Endothelial cells)
→
contain
→
Object:
tight_junctional_complexes
(Tight junction complex)
Original: Endothelial cells#contain#tight junctional complexes
#21968
high Confidence
Subject:
Endothelial_cells
(Endothelial cells)
→
contain
→
Object:
cytoplasmic_pseudopodia
(Pseudopodia)
Original: Endothelial cells#contain#cytoplasmic pseudopodia
#21967
high Confidence
Subject:
Cytoplasm
(Cytoplasm)
→
is
→
Object:
pale_and_finely_vacuolated
(Cytoplasmic phenotype)
Original: Cytoplasm#is#pale and finely vacuolated
#21966
high Confidence
Subject:
Pleomorphic_nuclei
(Nucleus)
→
contain
→
Object:
nucleoli
(Nucleolus)
Original: Pleomorphic nuclei#contain#one or two nucleoli
#21965
high Confidence
Subject:
Pleomorphic_nuclei
(Nucleus)
→
contain
→
Object:
finely_particulate_chromatin
(Chromatin)
Original: Pleomorphic nuclei#contain#finely particulate chromatin
#21964
high Confidence
Subject:
Lymphocytes
(Immune cells)
→
have
→
Object:
inconspicuous_nucleoli
(Subcellular structure)
Original: Lymphocytes#have#inconspicuous nucleoli
#21963
high Confidence
Subject:
Interdigitating_dendritic_cell_tumor
(Rare tumors)
→
occurs_primarily_in
→
Object:
lymph_nodes
(Lymph nodes)
Original: Interdigitating dendritic cell tumor (IDCT)#occurs primarily in#lymph nodes
#21962
high Confidence
Subject:
Interdigitating_dendritic_cell_tumor
(Rare tumors)
→
is
→
Object:
extremely_rare_malignancy
(Disease characteristics)
Original: Interdigitating dendritic cell tumor (IDCT)#is#an extremely rare malignancy
#21961
high Confidence
Subject:
Immunohistochemical_stains
(Immunohistochemistry)
→
assist_in
→
Object:
tumor_diagnosis
(Tumor Diagnosis)
Original: Histochemical and immunohistochemical stains#assist in#diagnosis of this tumor
#21960
high Confidence
Subject:
Histochemical_stains
(Histological techniques)
→
assist_in
→
Object:
tumor_diagnosis
(Tumor Diagnosis)
Original: Histochemical and immunohistochemical stains#assist in#diagnosis of this tumor
#21959
high Confidence
Subject:
Small-cell_variant_of_RO
(Tumor subtype)
→
is_associated_with
→
Object:
good_prognosis
(Good prognosis)
Original: Small-cell variant of RO#is considered#benign renal neoplasms with good prognosis
#21958
high Confidence
Subject:
NUT
(Protein coding genes)
→
is_involved_in
→
Object:
gene_rearrangement_t(15;19)
(Type of gene rearrangement)
Original: Cytogenetic analyses#revealed#a t(15;19) and BRD4-NUT gene rearrangement
#21957
high Confidence
Subject:
BRD4
(Protein coding genes)
→
is_involved_in
→
Object:
gene_rearrangement_t(15;19)
(Type of gene rearrangement)
Original: Cytogenetic analyses#revealed#a t(15;19) and BRD4-NUT gene rearrangement
#21956
high Confidence
Subject:
EWSR1-FLI1_fusion_transcript
(Fusion gene transcript)
→
is_detected_in
→
Object:
tumor_cells
(Tumor cells)
Original: The tumor#showed strong expression of#CD99/ FLI1/ and CD56 and was positive for the EWSR1-FLI1 fusion transcript
#21955
high Confidence
Subject:
CD56
(Cell adhesion molecules)
→
is_highly_expressed_in
→
Object:
tumor_cells
(Tumor cells)
Original: The tumor#showed strong expression of#CD99/ FLI1/ and CD56 and was positive for the EWSR1-FLI1 fusion transcript
#21954
high Confidence
Subject:
FLI1
(Transcription Factors)
→
is_highly_expressed_in
→
Object:
tumor_cells
(Tumor cells)
Original: The tumor#showed strong expression of#CD99/ FLI1/ and CD56 and was positive for the EWSR1-FLI1 fusion transcript
#21953
high Confidence
Subject:
CD99
(Cell surface proteins)
→
is_highly_expressed_in
→
Object:
tumor_cells
(Tumor cells)
Original: The tumor#showed strong expression of#CD99/ FLI1/ and CD56 and was positive for the EWSR1-FLI1 fusion transcript
#21952
high Confidence
Subject:
Urinary_cytology
(Diagnostic Methods)
→
is_useful_for
→
Object:
collecting_duct_carcinoma
(Tumor diseases)
Original: Urinary cytology#is useful for#diagnosing rare entities like collecting duct carcinoma
#21951
high Confidence
Subject:
FNA_biopsy
(Diagnostic techniques)
→
yields_diagnosis_of
→
Object:
papillary_thyroid_carcinoma
(Tumor type)
Original: FNA biopsy#yields diagnosis of#papillary thyroid carcinoma
#21950
high Confidence
Subject:
pituitary_carcinomas
(Tumor cell type)
→
are_defined_as
→
Object:
primary_adenohypophyseal_tumors_with_metastasis
(Disease phenotype)
Original: pituitary carcinomas#are defined as#rare primary adenohypophyseal tumors with cerebrospinal or extracranial metastasis
#21949
high Confidence
Subject:
pleomorphic_epithelioid_cells
(Cell Type)
→
are_negative_for
→
Object:
desmin
(protein)
Original: pleomorphic epithelioid cells#are negative for#S100 protein/ desmin
#21948
high Confidence
Subject:
pleomorphic_epithelioid_cells
(Cell Type)
→
are_negative_for
→
Object:
S100_protein
(protein)
Original: pleomorphic epithelioid cells#are negative for#S100 protein/ desmin
#21947
high Confidence
Subject:
pleomorphic_epithelioid_cells
(Cell Type)
→
are_immunoreactive_for
→
Object:
calponin
(protein)
Original: pleomorphic epithelioid cells#are immunoreactive for#HMB-45/ MART-1/ actin/ vimentin/ calponin
#21946
high Confidence
Subject:
pleomorphic_epithelioid_cells
(Cell Type)
→
are_immunoreactive_for
→
Object:
vimentin
(protein)
Original: pleomorphic epithelioid cells#are immunoreactive for#HMB-45/ MART-1/ actin/ vimentin/ calponin
#21945
high Confidence
Subject:
pleomorphic_epithelioid_cells
(Cell Type)
→
are_immunoreactive_for
→
Object:
actin
(protein)
Original: pleomorphic epithelioid cells#are immunoreactive for#HMB-45/ MART-1/ actin/ vimentin/ calponin
#21944
high Confidence
Subject:
pleomorphic_epithelioid_cells
(Cell Type)
→
are_immunoreactive_for
→
Object:
MART-1
(protein)
Original: pleomorphic epithelioid cells#are immunoreactive for#HMB-45/ MART-1/ actin/ vimentin/ calponin
#21943
high Confidence
Subject:
pleomorphic_epithelioid_cells
(Cell Type)
→
are_immunoreactive_for
→
Object:
HMB-45
(protein)
Original: pleomorphic epithelioid cells#are immunoreactive for#HMB-45/ MART-1/ actin/ vimentin/ calponin
#21942
high Confidence
Subject:
granulocytic_sarcoma_in_AML
(Tumor type)
→
have
→
Object:
chromosome_translocation_t(8;21)
(Chromosomal abnormalities)
Original: Granulocytic sarcomas in AML#have#chromosome translocation t(8;21)
#21941
high Confidence
Subject:
tumor
(Tumor)
→
was_diagnosed_as
→
Object:
LELC
(disease)
Original: Tumor#was diagnosed as#LELC
#21940
high Confidence
Subject:
lymphoepithelioma
(Tumor)
→
originates_from
→
Object:
nasopharynx
(Anatomical location)
Original: Lymphoepithelioma#is#a poorly differentiated/ non-keratinizing squamous cell carcinoma of the nasopharynx
#21939
high Confidence
Subject:
lymphoepithelioma
(Tumor)
→
is
→
Object:
non-keratinizing_squamous_cell_carcinoma
(Tumor type)
Original: Lymphoepithelioma#is#a poorly differentiated/ non-keratinizing squamous cell carcinoma of the nasopharynx
#21938
high Confidence
Subject:
lymphoepithelioma
(Tumor)
→
is
→
Object:
poorly_differentiated_squamous_cell_carcinoma
(Tumor type)
Original: Lymphoepithelioma#is#a poorly differentiated/ non-keratinizing squamous cell carcinoma of the nasopharynx
#21937
high Confidence
Subject:
HLRCC_associated_renal_cell_carcinomas
(Tumor type)
→
present_as
→
Object:
high_stage_at_presentation
(Disease phenotype)
Original: HLRCC-associated renal cell carcinomas#are#high stage at presentation
#21936
high Confidence
Subject:
Endoscopic_ultrasound-guided_fine_needle_aspiration
(Diagnostic Methods)
→
diagnoses
→
Object:
metastatic_sex_cord_tumor
(Tumor type)
Original: Endoscopic ultrasound-guided fine needle aspiration#diagnoses#metastatic sex cord tumor
#21935
high Confidence
Subject:
Immunohistochemical_stain
(Detection Methods)
→
confirmed
→
Object:
diagnosis_of_epithelioid_angiosarcoma
(Diagnosis conclusion)
Original: Immunohistochemical stain#confirmed#diagnosis of epithelioid angiosarcoma
#21934
high Confidence
Subject:
SMARCB1
(Protein coding genes)
→
is_member_of
→
Object:
SWI/SNF_chromatin_remodeling_complex
(Protein complex)
Original: SMARCB1 gene#is a member of#SWI/SNF chromatin remodeling complex
#21933
high Confidence
Subject:
keratin
(Structural proteins)
→
shows
→
Object:
intense_expression
(Protein expression level)
Original: immunohistochemical staining#demonstrates#intense expression of CD31/ CD34/ factor VIII related antigen/ and keratin
#21932
high Confidence
Subject:
factor_VIII_related_antigen
(Enzymes)
→
shows
→
Object:
intense_expression
(Protein expression level)
Original: immunohistochemical staining#demonstrates#intense expression of CD31/ CD34/ factor VIII related antigen/ and keratin
#21931
high Confidence
Subject:
CD34
(Receptor protein)
→
shows
→
Object:
intense_expression
(Protein expression level)
Original: immunohistochemical staining#demonstrates#intense expression of CD31/ CD34/ factor VIII related antigen/ and keratin
#21930
high Confidence
Subject:
CD31
(Receptor protein)
→
shows
→
Object:
intense_expression
(Protein expression level)
Original: immunohistochemical staining#demonstrates#intense expression of CD31/ CD34/ factor VIII related antigen/ and keratin
#21929
high Confidence
Subject:
presence_of_two_cytologic_criteria
(Diagnostic criteria)
→
achieves
→
Object:
specificity_of_96_percent
(Diagnostic performance indicators)
Original: Presence of two cytologic criteria#achieves#a sensitivity of 85% and specificity of 96%
#21928
high Confidence
Subject:
presence_of_two_cytologic_criteria
(Diagnostic criteria)
→
achieves
→
Object:
sensitivity_of_85_percent
(Diagnostic performance indicators)
Original: Presence of two cytologic criteria#achieves#a sensitivity of 85% and specificity of 96%
#21927
high Confidence
Subject:
malignant_melanoma
(Tumor diseases)
→
is_diagnosed_by
→
Object:
fine_needle_aspiration_biopsy
(Diagnostic techniques)
Original: Malignant melanoma#is diagnosed by#fine needle aspiration (FNA) biopsy
#21926
high Confidence
Subject:
tuberous_sclerosis
(disease)
→
involves
→
Object:
central_nervous_system
(Organ systems)
Original: Tuberous sclerosis#involves#CNS in children aged 2 days to 15 years
#21925
high Confidence
Subject:
diagnosis_of_metastatic_clear_cell_renal_cell_carcinoma
(Diagnostic Process)
→
is_based_on
→
Object:
immunohistochemical_staining_pattern
(Immunohistochemical characteristics)
Original: Diagnosis of metastatic clear cell renal cell carcinoma#is based on#morphologic features and immunohistochemical staining pattern
#21924
high Confidence
Subject:
diagnosis_of_metastatic_clear_cell_renal_cell_carcinoma
(Diagnostic Process)
→
is_based_on
→
Object:
morphologic_features
(Morphological characteristics)
Original: Diagnosis of metastatic clear cell renal cell carcinoma#is based on#morphologic features and immunohistochemical staining pattern
#21923
high Confidence
Subject:
Ovarian_or_tubal_HGSC
(Tumor diseases)
→
can_be_detected_using
→
Object:
cervical_liquid-based_cytology
(Diagnostic techniques)
Original: Ovarian or tubal HGSC#can be detected using#cervical liquid-based cytology
#21922
high Confidence
Subject:
T_cells
(Immune cells)
→
display
→
Object:
monoclonal_T-cell_rearrangement_of_T-cell_receptor-gamma_chain
(Genetic variation)
Original: Cases#displayed#a monoclonal T-cell rearrangement of the T-cell receptor-gamma chain
#21921
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
expresses
→
Object:
EBER
(EBV-encoded RNA)
Original: Tumor cells#expressed#CD3/ cytotoxic protein/ and EBER
#21920
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
expresses
→
Object:
CD3
(cell marker molecules)
Original: Tumor cells#expressed#CD3/ cytotoxic protein/ and EBER
#21919
high Confidence
Subject:
CD20
(Differentiation antigen)
→
is_positively_expressed_in
→
Object:
tumor_cells
(Tumor cells)
Original: Tumor cells#revealed#positive expression of CD20 by Immunohistochemistry
#21918
high Confidence
Subject:
GATA3_immunostaining
(Immunohistochemistry)
→
is_helpful_in
→
Object:
diagnostic_metastatic_breast_carcinoma_in_thyroid_metastasis
(Diagnostic Process)
Original: GATA-3 immunostaining#was helpful in#diagnosing metastatic breast carcinoma in thyroid metastasis
#21917
high Confidence
Subject:
ETV6
(Protein coding genes)
→
translocation_confirmed_by_FISH
→
Object:
MASC
(Tumor type)
Original: Superficial parotidectomy#revealed#MASC confirmed by FISH studies for ETV6 translocation
#21916
high Confidence
Subject:
anaplastic_carcinoma
(Tumor type)
→
should_be_separated_from
→
Object:
carcinoma_showing_thymus-like_differentiation
(Tumor type)
Original: Anaplastic carcinoma#should be separated from#carcinoma showing thymus-like differentiation
#21915
high Confidence
Subject:
histopathologic_examination
(Pathological examination)
→
revealed
→
Object:
LGFMS
(Tumor type)
Original: Histopathologic examination#revealed#LGFMS
#21914
high Confidence
Subject:
Ewing_sarcoma/primitive_neuroectodermal_tumor
(Tumor)
→
is_highly_aggressive
→
Object:
aggressiveness
(Tumor phenotype)
Original: Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET)#is#a highly aggressive small round cell tumor
#21913
high Confidence
Subject:
Ewing_sarcoma/primitive_neuroectodermal_tumor
(Tumor)
→
is_a
→
Object:
small_round_cell_tumor
(Tumor phenotype)
Original: Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET)#is#a highly aggressive small round cell tumor
#21912
high Confidence
Subject:
ALK-rearranged_lung_adenocarcinoma
(Molecular classification of tumors)
→
is_associated_with
→
Object:
distinctive_morphologic_patterns
(Histological phenotype)
Original: ALK-rearranged lung adenocarcinoma#is associated with#distinctive morphologic patterns
#21911
high Confidence
Subject:
CAM_5.2
(Cytokeratin)
→
is_positive_in
→
Object:
all_cases
(Case)
Original: AE1/AE3 and/or CAM 5.2#are positive in#all cases
#21910
high Confidence
Subject:
AE1/AE3
(Cytokeratin)
→
is_positive_in
→
Object:
all_cases
(Case)
Original: AE1/AE3 and/or CAM 5.2#are positive in#all cases
#21909
high Confidence
Subject:
cytological_ascitic_finding
(Cytology)
→
represented
→
Object:
malignant_feature_of_tumor
(Tumor phenotype)
Original: cytological ascitic findings#represent#malignant features of the tumor
#21908
high Confidence
Subject:
pancreatic_mass
(Neoplastic lesions)
→
shows
→
Object:
liver_metastasis
(Metastatic lesions)
Original: 1 mass#had apparent#liver metastasis
#21907
high Confidence
Subject:
pancreatic_mass
(Neoplastic lesions)
→
located_in
→
Object:
head_of_pancreas
(Anatomical location)
Original: masses#were located#in the head of the pancreas
#21906
high Confidence
Subject:
acinar_cell_carcinoma_of_pancreas
(Tumor diseases)
→
is
→
Object:
extremely_uncommon
(Epidemiological characteristics)
Original: Acinar cell carcinoma of pancreas#is#extremely uncommon
#21905
high Confidence
Subject:
malignant_smear
(Cytology)
→
diagnoses_as
→
Object:
malignant
(Diagnosis)
Original: 137 smears#diagnosed as#"negative/" 45 of which confirmed malignant
#21904
high Confidence
Subject:
cytological_smear
(Cytology)
→
diagnoses_as
→
Object:
negative
(Diagnosis)
Original: 137 smears#diagnosed as#"negative/" 45 of which confirmed malignant
#21903
high Confidence
Subject:
histology
(Pathological diagnosis)
→
confirms
→
Object:
cytologic_diagnosis_of_metastatic_osteosarcoma
(Diagnosis conclusion)
Original: The cytologic diagnosis of metastatic osteosarcoma#was confirmed by#histology after tumor resection
#21902
high Confidence
Subject:
IHC_markers
(Immunohistochemical markers)
→
are_valuable_for
→
Object:
final_diagnosis_of_amelanotic_melanoma
(Disease diagnosis)
Original: IHC markers#are valuable for#final diagnosis of amelanotic melanoma
#21901
high Confidence
Subject:
IHC_slides
(Immunohistochemistry)
→
confirms
→
Object:
amelanotic_melanoma_diagnosis
(Disease diagnosis)
Original: IHC slides#confirmed#amelanotic melanoma diagnosis
#21900
high Confidence
Subject:
CD56
(Cell adhesion molecules)
→
confirms_diagnosis_of
→
Object:
large_cell_neuroendocrine_carcinoma
(disease)
Original: CD56 expression#was#a reliable marker in confirming a diagnosis of large cell neuroendocrine carcinoma
#21899
high Confidence
Subject:
DNA_repair_defect
(DNA repair defects)
→
is_targetable_alteration_in
→
Object:
acinar_carcinoma
(Tumor type)
Original: Targetable molecular alterations in acinar carcinoma#include#BRAF rearrangements and DNA repair defects
#21898
high Confidence
Subject:
chromosome_11p_loss
(Chromosomal abnormalities)
→
is_molecular_feature_of
→
Object:
pancreatoblastoma
(Tumor type)
Original: Alterations in WNT signaling and chromosomal 11p loss#are common molecular features of#acinar cell carcinoma and pancreatoblastoma
#21897
high Confidence
Subject:
alterations_in_WNT_signaling
(Abnormal signaling pathways)
→
are_molecular_features_of
→
Object:
pancreatoblastoma
(Tumor type)
Original: Alterations in WNT signaling and chromosomal 11p loss#are common molecular features of#acinar cell carcinoma and pancreatoblastoma
#21896
high Confidence
Subject:
chromosome_11p_loss
(Chromosomal abnormalities)
→
is_molecular_feature_of
→
Object:
acinar_cell_carcinoma
(Tumor type)
Original: Alterations in WNT signaling and chromosomal 11p loss#are common molecular features of#acinar cell carcinoma and pancreatoblastoma
#21895
high Confidence
Subject:
alterations_in_WNT_signaling
(Abnormal signaling pathways)
→
are_molecular_features_of
→
Object:
acinar_cell_carcinoma
(Tumor type)
Original: Alterations in WNT signaling and chromosomal 11p loss#are common molecular features of#acinar cell carcinoma and pancreatoblastoma
#21894
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
were_reactive_for
→
Object:
CD20
(Immune markers)
Original: Tumor cells#were reactive for#CD45/ CD20
#21893
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
were_reactive_for
→
Object:
CD45
(Immune markers)
Original: Tumor cells#were reactive for#CD45/ CD20
#21892
high Confidence
Subject:
malignant_rhabdoid_tumor
(Tumor type)
→
is_characterized_by
→
Object:
prominent_nucleolus
(Cell morphology)
Original: Primary malignant rhabdoid tumor#is characterized by#hyaline cytoplasmic inclusions/ rounded or bean-shaped nucleus/ vesicular chromatin/ central prominent nucleolus
#21891
high Confidence
Subject:
malignant_rhabdoid_tumor
(Tumor type)
→
is_characterized_by
→
Object:
vesicular_chromatin
(Cell morphology)
Original: Primary malignant rhabdoid tumor#is characterized by#hyaline cytoplasmic inclusions/ rounded or bean-shaped nucleus/ vesicular chromatin/ central prominent nucleolus
#21890
high Confidence
Subject:
malignant_rhabdoid_tumor
(Tumor type)
→
is_characterized_by
→
Object:
rounded_nucleus
(Cell morphology)
Original: Primary malignant rhabdoid tumor#is characterized by#hyaline cytoplasmic inclusions/ rounded or bean-shaped nucleus/ vesicular chromatin/ central prominent nucleolus
#21889
high Confidence
Subject:
malignant_rhabdoid_tumor
(Tumor type)
→
is_characterized_by
→
Object:
hyaline_cytoplasmic_inclusions
(Cell morphology)
Original: Primary malignant rhabdoid tumor#is characterized by#hyaline cytoplasmic inclusions/ rounded or bean-shaped nucleus/ vesicular chromatin/ central prominent nucleolus
#21888
high Confidence
Subject:
lymph_node_biopsy
(Clinical testing)
→
confirmed
→
Object:
mantle_cell_lymphoma
(disease)
Original: lymph node biopsy#confirmed#mantle cell lymphoma
#21887
high Confidence
Subject:
Soluble_adenylyl_cyclase
(Adenylate cyclase)
→
is
→
Object:
diagnostic_marker_for_pigmented_skin_lesions
(Diagnostic markers)
Original: Soluble adenylyl cyclase (sAC)#is#a diagnostic marker for pigmented skin lesions
#21886
high Confidence
Subject:
Primary_effusion_lymphoma
(Tumor diseases)
→
is_associated_with
→
Object:
HHV-8
(Virus)
Original: Primary effusion lymphoma (PEL)#is associated with#human herpes virus-8 (HHV-8)
#21885
high Confidence
Subject:
histopathological_analysis
(Diagnostic Methods)
→
revealed
→
Object:
positive_H3_K27M_mutant_protein
(Protein modification)
Original: histopathological analysis#revealed#positive H3 K27M mutant protein and diffusely infiltrating growth
#21884
high Confidence
Subject:
Immunohistochemical analysis
(Molecular detection technology)
→
confirmed
→
Object:
diagnosis_of_intravascular_large_B-cell_lymphoma
(Disease diagnosis)
Original: immunohistochemical analysis#confirmed#diagnosis of intravascular large B-cell lymphoma
#21883
high Confidence
Subject:
renal_biopsy
(Histological examination)
→
diagnosed
→
Object:
intravascular_large_B-cell_lymphoma
(Disease diagnosis)
Original: a 41-year-old Chinese woman#was diagnosed with#intravascular large B-cell lymphoma by renal biopsy
#21882
high Confidence
Subject:
FNAB
(Imaging diagnostic technology)
→
is
→
Object:
diagnostic_technique_for_breast
(Diagnostic techniques)
Original: Fine-needle aspiration biopsy (FNAB)#is#a diagnostic technique for the breast
#21881
high Confidence
Subject:
BRG1_loss
(Loss of protein expression)
→
diagnoses
→
Object:
SMARCA4_deficient_esophageal_carcinoma
(Tumor type)
Original: SMARCA4 deficient esophageal carcinoma#was diagnosed based on#loss of BRG1 by immunostain and deep deletion confirmed by next-generation sequencing
#21880
high Confidence
Subject:
MYB_immunoexpression
(Protein expression characteristics)
→
is_common_in
→
Object:
ACC
(Tumor type)
Original: MYB immunoexpression#is common in#ACC
#21879
high Confidence
Subject:
CD7
(T cell markers)
→
is_negative_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: neoplastic cells#are negative for#T-cell markers (CD2/ CD3/ CD5/ CD7)
#21878
high Confidence
Subject:
CD5
(T cell markers)
→
is_negative_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: neoplastic cells#are negative for#T-cell markers (CD2/ CD3/ CD5/ CD7)
#21877
high Confidence
Subject:
CD3
(T cell markers)
→
is_negative_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: neoplastic cells#are negative for#T-cell markers (CD2/ CD3/ CD5/ CD7)
#21876
high Confidence
Subject:
CD2
(T cell markers)
→
is_negative_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: neoplastic cells#are negative for#T-cell markers (CD2/ CD3/ CD5/ CD7)
#21875
high Confidence
Subject:
BCL2
(Anti-apoptotic proteins)
→
is_expressed_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: neoplastic cells#express#B-cell markers (CD19/ CD20/ CD79a/ PAX5/ BCL-2)
#21874
high Confidence
Subject:
PAX5
(Transcription Factors)
→
is_expressed_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: neoplastic cells#express#B-cell markers (CD19/ CD20/ CD79a/ PAX5/ BCL-2)
#21873
high Confidence
Subject:
CD79A
(B cell markers)
→
is_expressed_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: neoplastic cells#express#B-cell markers (CD19/ CD20/ CD79a/ PAX5/ BCL-2)
#21872
high Confidence
Subject:
CD20
(B cell markers)
→
is_expressed_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: neoplastic cells#express#B-cell markers (CD19/ CD20/ CD79a/ PAX5/ BCL-2)
#21871
high Confidence
Subject:
CD19
(B cell markers)
→
is_expressed_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: neoplastic cells#express#B-cell markers (CD19/ CD20/ CD79a/ PAX5/ BCL-2)
#21870
high Confidence
Subject:
CD163
(Molecular markers)
→
is_useful_for
→
Object:
diagnosis_of_histiocytic_sarcoma
(diagnosis)
Original: CD163#is very useful for#diagnosis of histiocytic sarcoma
#21869
high Confidence
Subject:
Fine_needle_aspiration_cytology
(Diagnostic techniques)
→
provides
→
Object:
diagnostic_approach
(Diagnostic Methods)
Original: Fine needle aspiration cytology#provides#a convenient/ safe and effective diagnostic approach
#21868
high Confidence
Subject:
Eccrine_porocarcinoma
(Tumor type)
→
is_a
→
Object:
adenocarcinoma_of_eccrine_sweat_gland
(Tumor type)
Original: Eccrine porocarcinoma#is#an adenocarcinoma of the eccrine sweat gland
#21867
high Confidence
Subject:
Epstein-Barr_virus
(Virus)
→
is_implicated_in
→
Object:
AIDS-related_primary_CNS_lymphoma
(disease)
Original: Epstein-Barr virus (EBV)#is implicated in#AIDS-related primary CNS lymphoma
#21866
high Confidence
Subject:
Necrosis
(Cell death process)
→
is_important_for
→
Object:
diagnosis_of_uterine_leiomyosarcoma
(Disease diagnosis)
Original: Presence of mitosis and/or necrosis#is important for#diagnosis of uterine leiomyosarcoma
#21865
high Confidence
Subject:
Mitosis
(Cellular Processes)
→
is_important_for
→
Object:
diagnosis_of_uterine_leiomyosarcoma
(Disease diagnosis)
Original: Presence of mitosis and/or necrosis#is important for#diagnosis of uterine leiomyosarcoma
#21864
high Confidence
Subject:
serum_AFP
(Serum biomarkers)
→
has_adjunctive_role_in
→
Object:
HCC
(Tumor type)
Original: The cytologic features of fine needle aspiration biopsies from well- and poorly differentiated HCC#were reviewed and#the adjunctive role of serum AFP/ HBV markers and radiologic findings evaluated
#21863
high Confidence
Subject:
CD10
(Protein markers)
→
indicates
→
Object:
endometrial_stroma
(Interstitial tissue)
Original: CD10 marker#indicates#endometrial stroma
#21862
high Confidence
Subject:
ROS1_protein
(Receptor tyrosine kinases)
→
identifies
→
Object:
patients_suitable_for_molecular_targeted_therapy
(Patient population)
Original: Immunocytochemical detection of ROS1 protein#helps identify#patients suitable for molecular targeted therapy
#21861
high Confidence
Subject:
ROS1
(Protein coding genes)
→
is_rearranged_in
→
Object:
lung_adenocarcinoma
(Solid Tumors)
Original: A young woman#was diagnosed with#ROS1-rearranged lung adenocarcinoma
#21860
high Confidence
Subject:
ROS1-rearranged_lung_adenocarcinoma
(Molecular classification of tumors)
→
has_been_identified
→
Object:
lung_adenocarcinoma
(Tumor type)
Original: ROS1-rearranged lung adenocarcinoma#has been#recently identified
#21859
high Confidence
Subject:
Cysts
(Cyst structure)
→
are_lined_by
→
Object:
single_layer_of_flattened_cuboidal_columnar_and_hobnail_epithelium
(Epithelial type)
Original: Cysts#are lined by#a single layer of flattened/ cuboidal/columnar/ and hobnail epithelium
#21858
high Confidence
Subject:
Literature
(literature)
→
has_been
→
Object:
relatively_small_for_Tubulocystic_renal_cell_carcinoma
(Study sample size)
Original: Literature#has been#relatively small for tubulocystic renal cell carcinoma
#21857
high Confidence
Subject:
Tubulocystic_renal_cell_carcinoma
(Kidney tumors)
→
is_a
→
Object:
rare_kidney_neoplasm
(Kidney tumors)
Original: Tubulocystic renal cell carcinoma#is#a rare kidney neoplasm with low metastatic tendency
#21856
high Confidence
Subject:
postoperative_radiotherapy
(Postoperative radiotherapy)
→
is_used_as_adjuvant_treatment_for
→
Object:
oncocytic_carcinoma
(Tumor diseases)
Original: Postoperative radiotherapy#is used as#adjuvant treatment for oncocytic carcinoma
#21855
high Confidence
Subject:
surgery
(Surgery)
→
is_principal_treatment_for
→
Object:
oncocytic_carcinoma
(Tumor diseases)
Original: Surgery#is#the principal treatment for oncocytic carcinoma
#21854
high Confidence
Subject:
diagnostic_criteria
(Diagnostic criteria)
→
are_defined_for
→
Object:
limited_adenocarcinoma_of_prostate
(Disease Type)
Original: diagnostic criteria#are defined for#limited adenocarcinoma of the prostate
#21853
high Confidence
Subject:
diagnosis
(Diagnosis conclusion)
→
is
→
Object:
spindle_cell_carcinoma
(Disease Type)
Original: Diagnosis#is#spindle cell carcinoma
#21852
high Confidence
Subject:
number_of_AgNORs
(Nucleolar organizing region count)
→
significantly_affected
→
Object:
4-year_survival_of_patients
(Survival)
Original: Number of AgNORs#significantly affected#4-year survival of patients
#21851
high Confidence
Subject:
RT-PCR
(Molecular detection technology)
→
revealed
→
Object:
NAB2_STAT6_fusion_gene
(Fusion gene)
Original: RT-PCR#revealed#NAB2-STAT6 fusion gene
#21850
high Confidence
Subject:
WHO_guidelines_revision
(Guideline revisions)
→
led_to
→
Object:
classification_of_HPCs_as_single_entity
(Tumor classification)
Original: WHO guidelines revision#led to#classification of SFTs and HPCs as a single tumor entity
#21849
high Confidence
Subject:
WHO_guidelines_revision
(Guideline revisions)
→
led_to
→
Object:
classification_of_SFTs_as_single_entity
(Tumor classification)
Original: WHO guidelines revision#led to#classification of SFTs and HPCs as a single tumor entity
#21848
high Confidence
Subject:
seminoma_cells
(Tumor cells)
→
stained_positive_for
→
Object:
PLAP
(Diagnostic markers)
Original: seminoma cells#stained positive for#placental alkaline phosphatase (PLAP)
#21847
high Confidence
Subject:
MCNs
(Cystic tumors)
→
are_characterized_by
→
Object:
KRAS_mutation
(Gene mutation)
Original: IPMNs and MCNs#are characterized by#driver mutations in KRAS/GNAS (IPMNs) and KRAS (MCNs)
#21846
high Confidence
Subject:
IPMNs
(Cystic tumors)
→
are_characterized_by
→
Object:
KRAS_mutation
(Gene mutation)
Original: IPMNs and MCNs#are characterized by#driver mutations in KRAS/GNAS (IPMNs) and KRAS (MCNs)
#21845
high Confidence
Subject:
PGR
(Nuclear receptors)
→
shows_high_expression_in
→
Object:
breast_cancer
(Tumor)
Original: hormone receptor expression#was high#and endocrine therapy was initiated
#21844
high Confidence
Subject:
ESR1
(Nuclear receptors)
→
shows_high_expression_in
→
Object:
breast_cancer
(Tumor)
Original: hormone receptor expression#was high#and endocrine therapy was initiated
#21843
high Confidence
Subject:
PD-L1_expression
(Protein expression)
→
was_detected_by
→
Object:
Immunohistochemistry
(Detection Technology)
Original: PD-L1 expression#was detected by#immunohistochemistry using PD-L1 22C3 IHC assay
#21842
high Confidence
Subject:
leukemic_presentation
(Disease characteristics)
→
is_associated_with
→
Object:
very_poor_prognosis
(Prognosis)
Original: Prognosis#is#very poor for ALCL with leukemic presentation
#21841
high Confidence
Subject:
patient
(Patient characteristics)
→
diagnosed_with
→
Object:
ALCL
(Disease Type)
Original: Patient#was diagnosed with#ALCL with a rare peripheral leukemic presentation
#21840
high Confidence
Subject:
RT-PCR
(Molecular detection technology)
→
indicated
→
Object:
fusion_gene_product_of_NPM1
(Fusion gene product)
Original: RT-PCR#indicated#fusion gene product of ALK and nucleophosmin
#21839
high Confidence
Subject:
RT-PCR
(Molecular detection technology)
→
indicated
→
Object:
fusion_gene_product_of_ALK
(Fusion gene product)
Original: RT-PCR#indicated#fusion gene product of ALK and nucleophosmin
#21838
high Confidence
Subject:
Goblet_cells
(Epithelial cells)
→
are_present_in
→
Object:
Barrett's_esophagus
(disease)
Original: Goblet cells#are present in#all cases/ confirming their utility in defining Barrett's esophagus
#21837
high Confidence
Subject:
neoplasm
(Tumor)
→
was_identified_as
→
Object:
malignant_granulosa-theca_cell_tumor
(Disease phenotype)
Original: neoplasm#was identified as#a malignant granulosa-theca cell tumor
#21836
high Confidence
Subject:
Ewing's_sarcoma
(Tumor type)
→
originates_from
→
Object:
neuroectodermal_cells
(Neuroectodermal cells)
Original: This aggressive and infrequent tumor#originates from#neuroectodermal cells
#21835
high Confidence
Subject:
TP53
(Protein coding genes)
→
is_mutated_in
→
Object:
ITAC
(Tumor type)
Original: TP53#is mutated in#IM and ITAC cases (c.832C>T and c.215G>A)
#21834
high Confidence
Subject:
TP53
(Protein coding genes)
→
is_mutated_in
→
Object:
IM
(Tumor type)
Original: TP53#is mutated in#IM and ITAC cases (c.832C>T and c.215G>A)
#21833
high Confidence
Subject:
Cells
(cell)
→
are_strongly_positive_for
→
Object:
CD43
(Membrane Protein)
Original: Cells#were strongly positive for#myeloperoxidase/ CD68/ lysozyme/ CD45/ CD117/ and CD43
#21832
high Confidence
Subject:
Cells
(cell)
→
are_strongly_positive_for
→
Object:
CD117
(Membrane Protein)
Original: Cells#were strongly positive for#myeloperoxidase/ CD68/ lysozyme/ CD45/ CD117/ and CD43
#21831
high Confidence
Subject:
Cells
(cell)
→
are_strongly_positive_for
→
Object:
CD45
(Membrane Protein)
Original: Cells#were strongly positive for#myeloperoxidase/ CD68/ lysozyme/ CD45/ CD117/ and CD43
#21830
high Confidence
Subject:
Cells
(cell)
→
are_strongly_positive_for
→
Object:
Lysozyme
(Enzymes)
Original: Cells#were strongly positive for#myeloperoxidase/ CD68/ lysozyme/ CD45/ CD117/ and CD43
#21829
high Confidence
Subject:
Cells
(cell)
→
are_strongly_positive_for
→
Object:
CD68
(Membrane Protein)
Original: Cells#were strongly positive for#myeloperoxidase/ CD68/ lysozyme/ CD45/ CD117/ and CD43
#21828
high Confidence
Subject:
Cells
(cell)
→
are_strongly_positive_for
→
Object:
myeloperoxidase
(Enzymes)
Original: Cells#were strongly positive for#myeloperoxidase/ CD68/ lysozyme/ CD45/ CD117/ and CD43
#21827
high Confidence
Subject:
high-molecular-weight_cytokeratin
(Cytoskeletal proteins)
→
confirms
→
Object:
presence_of_basal_cell_layer
(Organizational Structure)
Original: Immunohistochemical stains for high-molecular-weight cytokeratin#confirm#the presence of a basal cell layer
#21826
high Confidence
Subject:
Immunohistochemistry
(Molecular analysis technology)
→
was_performed_using
→
Object:
Ki-67
(Cell proliferation markers)
Original: Immunohistochemistry#was performed using#primary antibodies (1A4/ HHF35/ desmin/ glial fibrillary acidic protein/ CD31/ S-100/ vimentin/ Ki-67)
#21825
high Confidence
Subject:
Immunohistochemistry
(Molecular analysis technology)
→
was_performed_using
→
Object:
vimentin
(Structural proteins)
Original: Immunohistochemistry#was performed using#primary antibodies (1A4/ HHF35/ desmin/ glial fibrillary acidic protein/ CD31/ S-100/ vimentin/ Ki-67)
#21824
high Confidence
Subject:
Immunohistochemistry
(Molecular analysis technology)
→
was_performed_using
→
Object:
S-100
(Cell markers)
Original: Immunohistochemistry#was performed using#primary antibodies (1A4/ HHF35/ desmin/ glial fibrillary acidic protein/ CD31/ S-100/ vimentin/ Ki-67)
#21823
high Confidence
Subject:
Immunohistochemistry
(Molecular analysis technology)
→
was_performed_using
→
Object:
CD31
(Cell surface markers)
Original: Immunohistochemistry#was performed using#primary antibodies (1A4/ HHF35/ desmin/ glial fibrillary acidic protein/ CD31/ S-100/ vimentin/ Ki-67)
#21822
high Confidence
Subject:
Immunohistochemistry
(Molecular analysis technology)
→
was_performed_using
→
Object:
glial_fibrillary_acidic_protein
(Structural proteins)
Original: Immunohistochemistry#was performed using#primary antibodies (1A4/ HHF35/ desmin/ glial fibrillary acidic protein/ CD31/ S-100/ vimentin/ Ki-67)
#21821
high Confidence
Subject:
Immunohistochemistry
(Molecular analysis technology)
→
was_performed_using
→
Object:
desmin
(Structural proteins)
Original: Immunohistochemistry#was performed using#primary antibodies (1A4/ HHF35/ desmin/ glial fibrillary acidic protein/ CD31/ S-100/ vimentin/ Ki-67)
#21820
high Confidence
Subject:
Immunohistochemistry
(Molecular analysis technology)
→
was_performed_using
→
Object:
primary_antibody_HHF35
(Antibody)
Original: Immunohistochemistry#was performed using#primary antibodies (1A4/ HHF35/ desmin/ glial fibrillary acidic protein/ CD31/ S-100/ vimentin/ Ki-67)
#21819
high Confidence
Subject:
Immunohistochemistry
(Molecular analysis technology)
→
was_performed_using
→
Object:
primary_antibody_1A4
(Antibody)
Original: Immunohistochemistry#was performed using#primary antibodies (1A4/ HHF35/ desmin/ glial fibrillary acidic protein/ CD31/ S-100/ vimentin/ Ki-67)
#21818
high Confidence
Subject:
Cytological_examination
(Cytology)
→
is_used_to_screen_for
→
Object:
intraepithelial_neoplasms
(Tumor)
Original: Cytological examination#is used to screen for#squamous cell carcinoma or intraepithelial neoplasms
#21817
high Confidence
Subject:
Cytological_examination
(Cytology)
→
is_used_to_screen_for
→
Object:
squamous_cell_carcinoma
(Tumor)
Original: Cytological examination#is used to screen for#squamous cell carcinoma or intraepithelial neoplasms
#21816
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_negative_for
→
Object:
CD103
(Integrin αE chain)
Original: Immunophenotyping#was negative for#CD5/ CD10/ CD11c/ CD23/ CD25/ CD38/ and CD103
#21815
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_negative_for
→
Object:
CD38
(Cell surface antigens)
Original: Immunophenotyping#was negative for#CD5/ CD10/ CD11c/ CD23/ CD25/ CD38/ and CD103
#21814
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_negative_for
→
Object:
CD25
(IL-2 receptor alpha chain)
Original: Immunophenotyping#was negative for#CD5/ CD10/ CD11c/ CD23/ CD25/ CD38/ and CD103
#21813
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_negative_for
→
Object:
CD23
(Low affinity IgE receptor)
Original: Immunophenotyping#was negative for#CD5/ CD10/ CD11c/ CD23/ CD25/ CD38/ and CD103
#21812
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_negative_for
→
Object:
CD11c
(Integrin family proteins)
Original: Immunophenotyping#was negative for#CD5/ CD10/ CD11c/ CD23/ CD25/ CD38/ and CD103
#21811
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_negative_for
→
Object:
CD10
(Cell surface antigens)
Original: Immunophenotyping#was negative for#CD5/ CD10/ CD11c/ CD23/ CD25/ CD38/ and CD103
#21810
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_negative_for
→
Object:
CD5
(T cell differentiation antigen)
Original: Immunophenotyping#was negative for#CD5/ CD10/ CD11c/ CD23/ CD25/ CD38/ and CD103
#21809
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_positive_for
→
Object:
HLA-DR
(Human Leukocyte Antigen)
Original: Immunophenotyping#was positive for#CD19/ CD20/ IgG/ kappa/ and HLA-DR
#21808
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_positive_for
→
Object:
kappa
(Immunoglobulin light chain)
Original: Immunophenotyping#was positive for#CD19/ CD20/ IgG/ kappa/ and HLA-DR
#21807
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_positive_for
→
Object:
IgG
(Immunoglobulins)
Original: Immunophenotyping#was positive for#CD19/ CD20/ IgG/ kappa/ and HLA-DR
#21806
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_positive_for
→
Object:
CD20
(B cell differentiation antigen)
Original: Immunophenotyping#was positive for#CD19/ CD20/ IgG/ kappa/ and HLA-DR
#21805
high Confidence
Subject:
Immunophenotyping
(Immunophenotyping)
→
was_positive_for
→
Object:
CD19
(B cell differentiation antigen)
Original: Immunophenotyping#was positive for#CD19/ CD20/ IgG/ kappa/ and HLA-DR
#21804
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
label_with
→
Object:
MUC5AC
(Secretory mucin)
Original: Neoplastic cells#label with#markers of gastric pyloric gland differentiation
#21803
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
label_with
→
Object:
MUC6
(Secretory mucin)
Original: Neoplastic cells#label with#markers of gastric pyloric gland differentiation
#21802
high Confidence
Subject:
CD10_immunostaining
(Immunohistochemistry)
→
is_helpful_in
→
Object:
separating_metastatic_RCC_from_primary_ACN
(Diagnostic Process)
Original: CD10 immunostaining#is helpful in#separating metastatic RCC from primary ACN
#21801
high Confidence
Subject:
Immunohistochemical_analysis
(Diagnostic Methods)
→
is_essential_for
→
Object:
definitive_diagnosis
(Diagnosis conclusion)
Original: Microscopic evaluation/ immunohistochemical analysis/ and serological tests#are essential for#reaching a definitive diagnosis
#21800
high Confidence
Subject:
Microscopic_evaluation
(Diagnostic Methods)
→
is_essential_for
→
Object:
definitive_diagnosis
(Diagnosis conclusion)
Original: Microscopic evaluation/ immunohistochemical analysis/ and serological tests#are essential for#reaching a definitive diagnosis
#21799
high Confidence
Subject:
PSA
(protein)
→
is_used_as
→
Object:
prostatic_carcinoma_detection
(Disease phenotype)
Original: Immunocytochemical detection of PSA#was recognized as#a useful mean for prostatic carcinoma detection
#21798
high Confidence
Subject:
PSA
(Protein markers)
→
is_useful_in
→
Object:
cytology_specimen_detection
(Diagnostic testing)
Original: Prostate-specific antigen (PSA)#is useful in#cytology specimen detection
#21797
high Confidence
Subject:
adenocarcinoma in situ (AIS)
(Tumor type)
→
reveals
→
Object:
precursor_lesions
(Precursor lesions)
Original: AIS#reveals#a range of precursor lesions
#21796
high Confidence
Subject:
carcinogenic_polycyclic_hydrocarbons
(Environmental carcinogens)
→
cause
→
Object:
squamous_cell_carcinoma
(Tumor type)
Original: Squamous cell metaplasias and carcinomas#are caused by#carcinogenic polycyclic hydrocarbon exposure
#21795
high Confidence
Subject:
carcinogenic_polycyclic_hydrocarbons
(Environmental carcinogens)
→
cause
→
Object:
squamous_cell_metaplasia
(Histological lesions)
Original: Squamous cell metaplasias and carcinomas#are caused by#carcinogenic polycyclic hydrocarbon exposure
#21794
high Confidence
Subject:
SCNEC
(Tumor)
→
has_high_propensity_for
→
Object:
distant_metastasis
(Metastatic phenotype)
Original: Small cell neuroendocrine carcinoma (SCNEC)#has#a high propensity for distant metastases
#21793
high Confidence
Subject:
SCNEC
(Tumor)
→
is_associated_with
→
Object:
poor_prognosis
(Prognosis)
Original: Small cell neuroendocrine carcinoma (SCNEC)#is#a rare/ highly aggressive tumor with poor prognosis
#21792
high Confidence
Subject:
SCNEC
(Tumor)
→
is
→
Object:
rare_highly_aggressive_tumor
(Tumor phenotype)
Original: Small cell neuroendocrine carcinoma (SCNEC)#is#a rare/ highly aggressive tumor with poor prognosis
#21791
high Confidence
Subject:
masses
(Tumor tissue)
→
identified_as
→
Object:
meningotheliomatous_meningiomas
(Tumor type)
Original: masses#identified as#meningotheliomatous meningiomas with atypical features
#21790
high Confidence
Subject:
tumor
(Tumor tissue)
→
reveals
→
Object:
SMARCA4_deep_deletion
(Gene deletion)
Original: tumor#revealed#SMARCA4 deep deletion
#21789
high Confidence
Subject:
Systemic_anaplastic_large_cell_lymphoma
(Tumor)
→
was_treated_with
→
Object:
CHOP
(Chemotherapy drugs)
Original: patient#was put on#a regime of CHOP and is disease-free 33 months after diagnosis
#21788
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expressed
→
Object:
ALK1
(protein)
Original: tumor cells#expressed#CD30/ CD45/ EMA/ and ALK-1
#21787
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expressed
→
Object:
EMA
(protein)
Original: tumor cells#expressed#CD30/ CD45/ EMA/ and ALK-1
#21786
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expressed
→
Object:
CD45
(protein)
Original: tumor cells#expressed#CD30/ CD45/ EMA/ and ALK-1
#21785
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expressed
→
Object:
CD30
(protein)
Original: tumor cells#expressed#CD30/ CD45/ EMA/ and ALK-1
#21784
high Confidence
Subject:
Gastric-type endocervical adenocarcinoma (GAS)
(Tumor subtype)
→
is_variant_of
→
Object:
cervical_adenocarcinoma
(Tumor type)
Original: GAS#is#a clinically aggressive variant of cervical adenocarcinoma
#21783
high Confidence
Subject:
GLUT2
(Glucose transporter)
→
mutations_cause
→
Object:
Fanconi-Bickel_syndrome
(Single gene disease)
Original: Fanconi-Bickel syndrome#is caused by#mutations in the GLUT2 (SLC2A2) gene
#21782
high Confidence
Subject:
S100
(protein)
→
is_upregulated_in
→
Object:
melanoma
(Tumor)
Original: melanoma#is characterized by#large pleomorphic cells with eosinophilic cytoplasm/ prominent nucleoli/ and S100 protein
#21781
high Confidence
Subject:
CCND1_copy_number_gain
(Genomic changes)
→
is_associated_with
→
Object:
poor_prognosis
(Disease phenotype)
Original: increased copy number gains in 11q (cyclin D1)#is associated with#poor prognosis in melanoma
#21780
high Confidence
Subject:
Extraskeletal_myxoid_chondrosarcoma
(Neoplastic diseases)
→
is_characterized_by
→
Object:
recurrent_chromosomal_translocation_involving_NR4A3
(Genomic abnormalities)
Original: Extraskeletal myxoid chondrosarcoma (EMC)#is characterized by#recurrent chromosomal translocation involving NR4A3
#21779
high Confidence
Subject:
lymphocytic_smear_background
(Cell morphology)
→
indicates
→
Object:
type_B_thymomas
(Tumor type)
Original: lymphocytic smear background#indicated#type B thymomas in 87.5% of cases
#21778
high Confidence
Subject:
NUT_midline_carcinoma
(Tumor diseases)
→
shows_positive_immunostaining_with
→
Object:
NUT_antibody
(Diagnostic Antibodies)
Original: NMC#has#characteristic morphological features and positive immunostaining with NUT antibody
#21777
high Confidence
Subject:
NUT
(Protein coding genes)
→
rearrangement_detected_by
→
Object:
RT-PCR
(Diagnostic techniques)
Original: The diagnosis of NMC#is made by#demonstration of NUT rearrangement via immunohistochemistry/ FISH/ or RT-PCR
#21776
high Confidence
Subject:
NUT
(Protein coding genes)
→
rearrangement_detected_by
→
Object:
FISH
(Diagnostic techniques)
Original: The diagnosis of NMC#is made by#demonstration of NUT rearrangement via immunohistochemistry/ FISH/ or RT-PCR
#21775
high Confidence
Subject:
NUT
(Protein coding genes)
→
rearrangement_detected_by
→
Object:
Immunohistochemistry
(Diagnostic techniques)
Original: The diagnosis of NMC#is made by#demonstration of NUT rearrangement via immunohistochemistry/ FISH/ or RT-PCR
#21774
high Confidence
Subject:
NUT
(Protein coding genes)
→
chromosomal_rearrangement_of
→
Object:
NUT_at_15q14
(Chromosome structural variation)
Original: NMC#is characterized by#chromosomal rearrangements of the gene NUT at 15q14
#21773
high Confidence
Subject:
Fluorescence_in_situ_hybridisation_technique
(Molecular detection technology)
→
has_established_its_role_in
→
Object:
diagnosis_of_lymphoid_malignancies
(Tumor disease diagnosis)
Original: Fluorescence in-situ hybridisation technique#has established its role in#diagnosis of lymphoid malignancies
#21772
high Confidence
Subject:
tumor
(Tumor tissue)
→
is_positive_for
→
Object:
vimentin
(Cytoskeletal proteins)
Original: tumor#is positive for#keratins and vimentin
#21771
high Confidence
Subject:
tumor
(Tumor tissue)
→
is_positive_for
→
Object:
keratins
(Cytoskeletal proteins)
Original: tumor#is positive for#keratins and vimentin
#21770
high Confidence
Subject:
cells
(Tumor cells)
→
are_positive_for
→
Object:
HMB-45
(protein)
Original: cells#are positive for#HMB-45
#21769
high Confidence
Subject:
cells
(Tumor cells)
→
are_positive_for
→
Object:
S-100
(protein)
Original: cells#are positive for#S-100
#21768
high Confidence
Subject:
cytologic_diagnosis
(Diagnosis conclusion)
→
is
→
Object:
adenocarcinoma
(Adenocarcinoma)
Original: Cytologic diagnosis#was made as#adenocarcinoma
#21767
high Confidence
Subject:
intranodal_palisaded_myofibroblastoma
(Tumor type)
→
is_a
→
Object:
rare_lymph_node_mesenchymal_neoplasm
(Tumor phenotype)
Original: intranodal palisaded myofibroblastoma#is a#rare lymph node mesenchymal neoplasm
#21766
high Confidence
Subject:
melanotic_schwannoma
(Tumor type)
→
is_a
→
Object:
rare_pigmented_neural_tumor
(Tumor phenotype)
Original: melanotic schwannoma (MS)#is a#rare pigmented neural tumor
#21765
high Confidence
Subject:
fine_needle_aspiration_cytology
(Pathological diagnosis technology)
→
was_performed_in
→
Object:
intra_abdominal_tumor
(Tumor)
Original: fine-needle aspiration cytology#was performed in#intra-abdominal tumors
#21764
high Confidence
Subject:
malignant_tumor
(Tumor)
→
may_arise_from
→
Object:
ovarian_mature_cystic_teratoma
(Ovarian tumors)
Original: malignant tumors#may arise from#ovarian mature cystic teratoma
#21763
high Confidence
Subject:
Dnajb1-Prkaca_gene_fusion
(Gene fusion)
→
is_contained_in
→
Object:
human_FL-HCCs
(Tumor type)
Original: The tumors#contained#the Dnajb1-Prkaca gene fusion
#21762
high Confidence
Subject:
Needle_aspiration_cytology
(Cytology)
→
is_used_for
→
Object:
acinar-cell_carcinoma_diagnosis
(Acinar Cell Carcinoma Diagnosis)
Original: Needle aspiration cytology#is used for#acinar-cell carcinoma diagnosis
#21761
high Confidence
Subject:
Basal_cell_layer
(Basal cell layer)
→
is_lacking_in
→
Object:
prostatic_intraepithelial_neoplasia
(Prostatic intraepithelial neoplasia)
Original: Basal cell layer (BCL)#is lacking in#prostatic intraepithelial neoplasia (PMC)
#21760
high Confidence
Subject:
immunostaining_with_anticytokeratin_antibodies
(Immunohistochemistry)
→
is_significant_for
→
Object:
differential_diagnosis
(Diagnostic Process)
Original: Immunostaining with anticytokeratin antibodies#is significant for#differential diagnosis
#21759
high Confidence
Subject:
MYCN-amplified tumors
(MYCN-amplified tumors)
→
shows
→
Object:
poorly differentiated neuroblastoma subtype
(Poorly differentiated neuroblastoma subtypes)
Original: MYCN-amplified tumors#typically show#poorly differentiated neuroblastoma subtype
#21758
high Confidence
Subject:
HMB45
(Antibody)
→
marks
→
Object:
tumor_cases
(Tumor Cases)
Original: HMB45#marked#29/31 cases
#21757
high Confidence
Subject:
S100_protein
(protein)
→
is_expressed_in
→
Object:
tumor_cases
(Tumor Cases)
Original: S100 protein#was expressed in#33/36 cases
#21756
high Confidence
Subject:
polygonal_acidophilic_cells
(Tumor cells)
→
show
→
Object:
intense_cytoplasmic_staining_for_alpha-fetoprotein
(Protein expression characteristics)
Original: hepatoid areas#are characterized by#nests and cords of polygonal acidophilic cells with prominent nucleoli and intense cytoplasmic staining for alpha-fetoprotein
#21755
high Confidence
Subject:
large_cell_NEC
(Tumor cell subtype)
→
is_associated_with
→
Object:
very_poor_prognosis
(Disease Prognosis)
Original: large cell NEC#is associated with#a very poor prognosis (median survival time/ 15.2 months; 1-year survival rate/ 58%)
#21754
high Confidence
Subject:
neoplastic_melanocyte
(Tumor cells)
→
expresses
→
Object:
melanoma_antigen
(Tumor Antigens)
Original: Neoplastic melanocytes#express#vimentin/ S100 protein/ melan-A/ and melanoma antigen
#21753
high Confidence
Subject:
neoplastic_melanocyte
(Tumor cells)
→
expresses
→
Object:
melan-A
(melanin-related antigen)
Original: Neoplastic melanocytes#express#vimentin/ S100 protein/ melan-A/ and melanoma antigen
#21752
high Confidence
Subject:
neoplastic_melanocyte
(Tumor cells)
→
expresses
→
Object:
S100_protein
(Calcium Binding Protein)
Original: Neoplastic melanocytes#express#vimentin/ S100 protein/ melan-A/ and melanoma antigen
#21751
high Confidence
Subject:
neoplastic_melanocyte
(Tumor cells)
→
expresses
→
Object:
vimentin
(Intermediate filament protein)
Original: Neoplastic melanocytes#express#vimentin/ S100 protein/ melan-A/ and melanoma antigen
#21750
high Confidence
Subject:
neoplastic_trichoblast
(Tumor cells)
→
expresses
→
Object:
E-cadherin
(Cell adhesion molecules)
Original: Neoplastic trichoblasts#express#cytokeratins and E-cadherin
#21749
high Confidence
Subject:
neoplastic_trichoblast
(Tumor cells)
→
expresses
→
Object:
cytokeratins
(Structural proteins)
Original: Neoplastic trichoblasts#express#cytokeratins and E-cadherin
#21748
high Confidence
Subject:
patient
(patient)
→
diagnosed_with
→
Object:
Muir-Torre_syndrome
(disease)
Original: The patient#was diagnosed with#Muir-Torre syndrome
#21747
high Confidence
Subject:
tumor
(Tumor cell clusters)
→
is_diagnosed_as
→
Object:
PHNET_G2
(Extrahepatic neuroendocrine tumor grading)
Original: tumor#is diagnosed as#a PHNET G2
#21746
high Confidence
Subject:
histopathological_examination
(Histological examination)
→
reveals
→
Object:
primitive_neuroectodermal_tumor
(Tumor type)
Original: histopathological examination#reveals#a primitive neuroectodermal tumor (PNET)
#21745
high Confidence
Subject:
tumor
(Tumor cell clusters)
→
is_located_in
→
Object:
tail_of_pancreas
(Anatomical location)
Original: tumor#is located in#the tail of the pancreas
#21744
high Confidence
Subject:
tumoral_cell
(Tumor cells)
→
stained_positive_with
→
Object:
CD56
(Protein markers)
Original: tumoral cells#stained strongly positive with#synaptophysin/ chromogranin/ and CD56
#21743
high Confidence
Subject:
tumoral_cell
(Tumor cells)
→
stained_positive_with
→
Object:
Chromogranin
(Protein markers)
Original: tumoral cells#stained strongly positive with#synaptophysin/ chromogranin/ and CD56
#21742
high Confidence
Subject:
tumoral_cell
(Tumor cells)
→
stained_positive_with
→
Object:
synaptophysin
(Protein markers)
Original: tumoral cells#stained strongly positive with#synaptophysin/ chromogranin/ and CD56
#21741
high Confidence
Subject:
Perivascular_epithelioid_cells
(Tumor cells)
→
are_present_in
→
Object:
PEComas
(Tumor)
Original: Perivascular epithelioid cells (PECs)#are present in#a group of tumors called PEComas
#21740
high Confidence
Subject:
EGFR_mutation
(Gene mutation)
→
is_described_in
→
Object:
adenocarcinoma_of_the_lung
(Disease phenotype)
Original: EGFR mutations#are described in#adenocarcinomas of the lung
#21739
high Confidence
Subject:
large_cell_transformation
(Cell phenotype changes)
→
signals
→
Object:
worse_prognosis
(Clinical Outcomes)
Original: Large cell transformation#signals#a worse prognosis in indolent B-cell lymphomas
#21738
high Confidence
Subject:
myeloid_sarcoma
(Tumor)
→
exhibits
→
Object:
aberrant_expression_of_B-cell_markers
(Phenotypic markers)
Original: myeloid sarcoma#exhibits#aberrant expression of B-cell markers
#21737
high Confidence
Subject:
cells
(cell)
→
are_positive_for
→
Object:
leukocyte_common_antigen
(Immune markers)
Original: Cells#were positive for#leukocyte common antigen (LCA)
#21736
high Confidence
Subject:
lymphoma_cells
(Tumor cells)
→
negative_for
→
Object:
CD56
(Differentiation antigen)
Original: Lymphoma cells#were negative for#CD4/ CD19/ CD20/ CD103/ and CD56
#21735
high Confidence
Subject:
lymphoma_cells
(Tumor cells)
→
negative_for
→
Object:
CD103
(Differentiation antigen)
Original: Lymphoma cells#were negative for#CD4/ CD19/ CD20/ CD103/ and CD56
#21734
high Confidence
Subject:
lymphoma_cells
(Tumor cells)
→
negative_for
→
Object:
CD20
(Differentiation antigen)
Original: Lymphoma cells#were negative for#CD4/ CD19/ CD20/ CD103/ and CD56
#21733
high Confidence
Subject:
lymphoma_cells
(Tumor cells)
→
negative_for
→
Object:
CD19
(Differentiation antigen)
Original: Lymphoma cells#were negative for#CD4/ CD19/ CD20/ CD103/ and CD56
#21732
high Confidence
Subject:
lymphoma_cells
(Tumor cells)
→
negative_for
→
Object:
CD4
(Differentiation antigen)
Original: Lymphoma cells#were negative for#CD4/ CD19/ CD20/ CD103/ and CD56
#21731
high Confidence
Subject:
lymphoma_cells
(Tumor cells)
→
positive_for
→
Object:
TCR_beta_F1
(cell receptor)
Original: Lymphoma cells#were positive for#CD2/ CD3/ CD5/ CD8/ and TCR beta F1
#21730
high Confidence
Subject:
lymphoma_cells
(Tumor cells)
→
positive_for
→
Object:
CD8
(Differentiation antigen)
Original: Lymphoma cells#were positive for#CD2/ CD3/ CD5/ CD8/ and TCR beta F1
#21729
high Confidence
Subject:
lymphoma_cells
(Tumor cells)
→
positive_for
→
Object:
CD5
(Differentiation antigen)
Original: Lymphoma cells#were positive for#CD2/ CD3/ CD5/ CD8/ and TCR beta F1
#21728
high Confidence
Subject:
lymphoma_cells
(Tumor cells)
→
positive_for
→
Object:
CD3
(Differentiation antigen)
Original: Lymphoma cells#were positive for#CD2/ CD3/ CD5/ CD8/ and TCR beta F1
#21727
high Confidence
Subject:
lymphoma_cells
(Tumor cells)
→
positive_for
→
Object:
CD2
(Differentiation antigen)
Original: Lymphoma cells#were positive for#CD2/ CD3/ CD5/ CD8/ and TCR beta F1
#21726
high Confidence
Subject:
biopsy_specimens
(Tissue specimens)
→
revealed
→
Object:
malignant_lymphoma_of_diffuse_pleomorphic_type
(disease)
Original: Biopsy specimens#revealed#malignant lymphoma of diffuse pleomorphic type
#21725
high Confidence
Subject:
NONO-TFE3_dual-fusion_FISH_probe
(Molecular diagnostic tools)
→
is_effective_for
→
Object:
diagnosing_NONO-TFE3_RCC
(Diagnostic Process)
Original: NONO-TFE3 dual-fusion FISH probe#is effective for#diagnosing NONO-TFE3 RCC
#21724
high Confidence
Subject:
tumor
(Tumor)
→
diagnosed_as
→
Object:
presumed_spontaneous_astrocytoma
(Tumor)
Original: Tumor#diagnosed as#a presumed spontaneous astrocytoma
#21723
high Confidence
Subject:
Cytological_grading_system
(Cytological grading system)
→
evaluates
→
Object:
chromatin_pattern
(Chromatin pattern)
Original: Cytological grading system#evaluates#cellular arrangement/ pleomorphism/ anisonucleosis/ myoepithelial cells/ nucleoli/ and chromatin pattern
#21722
high Confidence
Subject:
Cytological_grading_system
(Cytological grading system)
→
evaluates
→
Object:
nucleoli
(Nucleolus)
Original: Cytological grading system#evaluates#cellular arrangement/ pleomorphism/ anisonucleosis/ myoepithelial cells/ nucleoli/ and chromatin pattern
#21721
high Confidence
Subject:
Cytological_grading_system
(Cytological grading system)
→
evaluates
→
Object:
myoepithelial_cells
(Myoepithelial cells)
Original: Cytological grading system#evaluates#cellular arrangement/ pleomorphism/ anisonucleosis/ myoepithelial cells/ nucleoli/ and chromatin pattern
#21720
high Confidence
Subject:
Cytological_grading_system
(Cytological grading system)
→
evaluates
→
Object:
anisonucleosis
(Nuclear heterogeneity)
Original: Cytological grading system#evaluates#cellular arrangement/ pleomorphism/ anisonucleosis/ myoepithelial cells/ nucleoli/ and chromatin pattern
#21719
high Confidence
Subject:
Cytological_grading_system
(Cytological grading system)
→
evaluates
→
Object:
Pleomorphism
(Polymorphism)
Original: Cytological grading system#evaluates#cellular arrangement/ pleomorphism/ anisonucleosis/ myoepithelial cells/ nucleoli/ and chromatin pattern
#21718
high Confidence
Subject:
Cytological_grading_system
(Cytological grading system)
→
evaluates
→
Object:
cellular_arrangement
(Cell Arrangement)
Original: Cytological grading system#evaluates#cellular arrangement/ pleomorphism/ anisonucleosis/ myoepithelial cells/ nucleoli/ and chromatin pattern
#21717
high Confidence
Subject:
t(11;14)
(Chromosomal translocation)
→
leads_to
→
Object:
BCL1_overexpression
(Protein coding gene expression)
Original: t(11;14)#leads to#over-expression of BCL1
#21716
high Confidence
Subject:
CA19-9
(Tumor markers)
→
exhibited
→
Object:
positive_expression_in_mucinous_material_in_dilated_glands
(Expression characteristics)
Original: CA19-9#exhibited#a focal/ not diffuse/ positive expression in hyperplastic epithelium and mucinous material in dilated glands
#21715
high Confidence
Subject:
CA19-9
(Tumor markers)
→
exhibited
→
Object:
focal_positive_expression_in_hyperplastic_epithelium
(Expression characteristics)
Original: CA19-9#exhibited#a focal/ not diffuse/ positive expression in hyperplastic epithelium and mucinous material in dilated glands
#21714
high Confidence
Subject:
FAB_classification
(FAB typing system)
→
includes
→
Object:
LMA-M0
(Acute Myeloid Leukemia Subtypes)
Original: FAB classification#includes#a myeloid leukemia subtype with minimal differentiation (LMA-MO)
#21713
high Confidence
Subject:
findings
(Histological findings)
→
are_highly_suggestive_of
→
Object:
ductal_carcinoma_in_biopsy_specimens
(Tumor Diagnosis)
Original: findings#are highly suggestive of#ductal carcinoma in biopsy specimens
#21712
high Confidence
Subject:
splenic_marginal_zone_lymphoma
(Neoplastic diseases)
→
is_diagnosed_in
→
Object:
22-year-old_woman
(Specific populations)
Original: splenic marginal zone lymphoma#is diagnosed in#a 22-year-old woman
#21711
high Confidence
Subject:
splenic_marginal_zone_lymphoma
(Neoplastic diseases)
→
mainly_affects
→
Object:
older_individuals
(Specific populations)
Original: splenic marginal zone lymphoma#mainly affects#older individuals
#21710
high Confidence
Subject:
very_large_prominent_nucleoli
(Nuclear morphology)
→
predictions
→
Object:
cancer
(Neoplastic diseases)
Original: very large prominent nucleoli#predict#cancer
#21709
high Confidence
Subject:
BCL2
(Anti-apoptotic proteins)
→
participates_in
→
Object:
carcinogenesis
(Tumorigenesis)
Original: Ki-67 and bcl-2 expression#participates in#carcinogenesis
#21708
high Confidence
Subject:
KI67
(Cell proliferation markers)
→
participates_in
→
Object:
carcinogenesis
(Tumorigenesis)
Original: Ki-67 and bcl-2 expression#participates in#carcinogenesis
#21707
high Confidence
Subject:
meningiomas
(Tumor type)
→
are_classified_into
→
Object:
anaplastic_grade_III
(Anaplastic meningioma)
Original: Meningiomas#are classified into#benign (grade I)/ atypical (grade II)/ and anaplastic (grade III)
#21706
high Confidence
Subject:
meningiomas
(Tumor type)
→
are_classified_into
→
Object:
atypical_grade_II
(Atypical meningioma)
Original: Meningiomas#are classified into#benign (grade I)/ atypical (grade II)/ and anaplastic (grade III)
#21705
high Confidence
Subject:
meningiomas
(Tumor type)
→
are_classified_into
→
Object:
benign_grade_I
(Benign meningioma)
Original: Meningiomas#are classified into#benign (grade I)/ atypical (grade II)/ and anaplastic (grade III)
#21704
high Confidence
Subject:
radiotherapy
(Radiation therapy)
→
treats
→
Object:
lymphoma
(disease)
Original: Patient#was given#radiotherapy 33 times after the biopsy
#21703
high Confidence
Subject:
patient
(patient)
→
was_diagnosed_with
→
Object:
grade_IV_osteoblastic_osteosarcoma
(Disease classification)
Original: patient#was diagnosed with#grade IV osteoblastic osteosarcoma
#21702
high Confidence
Subject:
NUT_gene_rearrangement
(Gene rearrangement)
→
is_associated_with
→
Object:
midline_carcinoma
(Tumor)
Original: Midline carcinomas#are associated with#NUT gene rearrangement
#21701
high Confidence
Subject:
solid_type_primary_pulmonary_ACC
(Tumor type)
→
diagnosed_by
→
Object:
bronchoscope_guided_fine_needle_aspiration
(Diagnostic techniques)
Original: Solid-type primary pulmonary ACC#diagnosed by#bronchoscope-guided fine needle aspiration
#21700
high Confidence
Subject:
Follicular_cells
(Tumor cells)
→
expresses
→
Object:
TTF-1
(Transcription Factors)
Original: These cells#were immunoreactive for#thyroglobulin and TTF-1
#21699
high Confidence
Subject:
Follicular_cells
(Tumor cells)
→
expresses
→
Object:
Thyroglobulin
(protein)
Original: These cells#were immunoreactive for#thyroglobulin and TTF-1
#21698
high Confidence
Subject:
Diagnosis
(Diagnostic behavior)
→
is_based_on
→
Object:
ultrastructural_findings
(Ultrastructural characteristics)
Original: Diagnosis#is based on#cytologic/ histopathologic/ immunohistochemical/ and ultrastructural findings
#21697
high Confidence
Subject:
Diagnosis
(Diagnostic behavior)
→
is_based_on
→
Object:
immunohistochemical_findings
(Immunohistochemical characteristics)
Original: Diagnosis#is based on#cytologic/ histopathologic/ immunohistochemical/ and ultrastructural findings
#21696
high Confidence
Subject:
Diagnosis
(Diagnostic behavior)
→
is_based_on
→
Object:
histopathologic_findings
(Histopathological characteristics)
Original: Diagnosis#is based on#cytologic/ histopathologic/ immunohistochemical/ and ultrastructural findings
#21695
high Confidence
Subject:
Diagnosis
(Diagnostic behavior)
→
is_based_on
→
Object:
cytologic_findings
(Cytological characteristics)
Original: Diagnosis#is based on#cytologic/ histopathologic/ immunohistochemical/ and ultrastructural findings
#21694
high Confidence
Subject:
Immunohistochemical_staining_for_HER2
(Protein expression detection)
→
shows
→
Object:
negative_score_0
(Protein expression status)
Original: Immunohistochemical staining for Her2#was found to be#negative (score 0)
#21693
high Confidence
Subject:
TNM_classification
(Diagnostic grading system)
→
diagnoses_as
→
Object:
T1cN0M0_stage_I
(Tumor stage)
Original: TNM classification#was diagnosed as#T1cN0M0 stage I
#21692
high Confidence
Subject:
Fine-needle_aspiration_cytology
(Diagnostic techniques)
→
is_performed_for
→
Object:
extraskeletal_Ewing's_sarcoma
(Neoplastic diseases)
Original: Fine-needle aspiration cytology#is performed for#extraskeletal Ewing's sarcoma
#21691
high Confidence
Subject:
fluorescence_in_situ_hybridization
(Detection Technology)
→
revealed
→
Object:
rearrangement_at_EWSR1_locus
(Gene rearrangement)
Original: Fluorescence in situ hybridization#revealed#rearrangement at EWSR1 locus
#21690
high Confidence
Subject:
primary_pulmonary_HCCC_cases
(Tumor Cases)
→
were_collected_from
→
Object:
Shanghai_Chest_Hospital
(Medical institutions)
Original: Primary pulmonary HCCC cases#were collected from#Shanghai Chest Hospital
#21689
high Confidence
Subject:
Category_3_tumor
(Tumor classification)
→
test_positive_for
→
Object:
YWHAE_rearrangement
(Gene rearrangement)
Original: Category 3 tumors#test positive for#YWHAE rearrangement
#21688
high Confidence
Subject:
Anaplastic_Wilms_Tumor
(Tumor type)
→
diagnosed_according to
→
Object:
BECKWITH_and_PALMER_criteria_1978
(Diagnostic criteria)
Original: Anaplastic WT#are diagnosed according to#criteria of BECKWITH and PALMER (1978)
#21687
high Confidence
Subject:
CD31
(Cell surface molecules)
→
is_positive_in
→
Object:
EHE_case
(Disease Cases)
Original: CD31#is positive in#88.9% of EHE cases
#21686
high Confidence
Subject:
ERG
(Transcription Factors)
→
is_positive_in
→
Object:
EHE_case
(Disease Cases)
Original: ERG#is most frequently positive in#EHE cases
#21685
high Confidence
Subject:
pleomorphic_adenoma
(Benign adenoma)
→
progresses_to
→
Object:
adenocarcinoma
(Adenocarcinoma)
Original: Adenoma#progresses to#adenocarcinoma
#21684
high Confidence
Subject:
Non-Wilms'_renal_malignant_neoplasm
(Tumor type)
→
must_be_distinguished_from
→
Object:
Wilms' tumor
(Tumor type)
Original: Non-Wilms' renal malignant neoplasms#must be distinguished from#common Wilms' tumor for appropriate chemotherapy
#21683
high Confidence
Subject:
Tumor
(Tumor)
→
shows_profile
→
Object:
luminal B immunohistochemical profile
(Molecular subtypes)
Original: Tumors#show#a luminal B immunohistochemical profile in the majority of cases
#21682
high Confidence
Subject:
intracranial_germinomas
(Tumor)
→
were_diagnosed_with
→
Object:
smear_technique
(Pathological technology)
Original: intracranial germinomas#were diagnosed with#the smear technique
#21681
high Confidence
Subject:
SMARCB1
(Protein coding genes)
→
expression_is_deficient_in
→
Object:
tumor_samples
(Tumor samples)
Original: SMARCB1 expression#was deficient in#all cases
#21680
high Confidence
Subject:
loss of immunohistochemical expression
(Loss of immunohistochemical expression)
→
diagnoses
→
Object:
FH deficiency
(Genetic metabolic defects)
Original: loss of immunohistochemical expression#diagnoses#FH deficiency
#21679
high Confidence
Subject:
hereditary_leiomyomatosis_and_renal_cell_carcinoma
(disease)
→
is_defined_by
→
Object:
germline_mutation_of_FH_gene
(Gene mutation)
Original: Hereditary leiomyomatosis and renal cell carcinoma#is defined by#germline mutation of FH gene
#21678
high Confidence
Subject:
PIK3CA_mutation
(Gene mutation)
→
is_present_in
→
Object:
tumor
(Tumor)
Original: Tumor#had#PIK3CA mutations
#21677
high Confidence
Subject:
EWSR1
(Gene)
→
is_rearranged_in
→
Object:
malignant_gastrointestinal_neuroectodermal_tumor
(Tumor diseases)
Original: fluorescence in situ hybridization analysis#demonstrated#EWSR1 rearrangement in both tumors
#21676
high Confidence
Subject:
systematic_approach
(Diagnostic Methods)
→
enables
→
Object:
cancer_diagnosis
(Diagnosis conclusion)
Original: Systematic approach#enables#correct cancer diagnosis in most cases during routine daily practice
#21675
high Confidence
Subject:
Granular_cell_tumor
(Tumor type)
→
are_derived_from
→
Object:
Schwann_cell
(Cell Type)
Original: Granular cell tumours#are derived from#Schwann cells
#21674
high Confidence
Subject:
Granular_cell_tumor
(Tumor type)
→
was_diagnosed_by
→
Object:
core_needle_biopsy
(Diagnostic Methods)
Original: Granular cell tumour#was diagnosed by#core needle biopsy
#21673
high Confidence
Subject:
radiation
(Treatment)
→
markedly_reduce
→
Object:
tumor_size
(Tumor phenotype)
Original: Steroids and radiation#markedly reduce#tumor size
#21672
high Confidence
Subject:
steroids
(drug)
→
markedly_reduce
→
Object:
tumor_size
(Tumor phenotype)
Original: Steroids and radiation#markedly reduce#tumor size
#21671
high Confidence
Subject:
clear_cell_carcinoma_of_the_lung
(Tumor type)
→
is
→
Object:
primary_carcinoma
(Tumor type)
Original: clear cell carcinoma of the lung#is#a primary carcinoma
#21670
high Confidence
Subject:
diagnosis_of_prostate_carcinoma
(diagnosis)
→
is_based_on
→
Object:
cytoplasmic_features
(Cytoplasmic characteristics)
Original: Diagnosis of prostate carcinoma#is based on#a constellation of architectural/ nuclear/ cytoplasmic/ and ancillary features
#21669
high Confidence
Subject:
diagnosis_of_prostate_carcinoma
(diagnosis)
→
is_based_on
→
Object:
nuclear_features
(Nuclear characteristics)
Original: Diagnosis of prostate carcinoma#is based on#a constellation of architectural/ nuclear/ cytoplasmic/ and ancillary features
#21668
high Confidence
Subject:
diagnosis_of_prostate_carcinoma
(diagnosis)
→
is_based_on
→
Object:
architectural_features
(Organizational structure characteristics)
Original: Diagnosis of prostate carcinoma#is based on#a constellation of architectural/ nuclear/ cytoplasmic/ and ancillary features
#21667
high Confidence
Subject:
invasive_lung_carcinomas
(Tumor type)
→
were_classified_by
→
Object:
IASLC_system
(Classification system)
Original: Invasive lung carcinomas#were classified by#IASLC system
#21666
high Confidence
Subject:
Telomerase
(Enzyme complex)
→
is_composed_of
→
Object:
RNA_subunit
(Noncoding RNA)
Original: telomerase#is composed of#reverse transcriptase catalytic subunit hTERT and RNA subunit
#21665
high Confidence
Subject:
Telomerase
(Enzyme complex)
→
is_composed_of
→
Object:
hTERT
(protein)
Original: telomerase#is composed of#reverse transcriptase catalytic subunit hTERT and RNA subunit
#21664
high Confidence
Subject:
SPC25_CpG_hypomethylation
(DNA methylation modification sites)
→
is_associated_with
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: Hypomethylation of CpG sites in SPC25#is associated with#poor prognosis in UCEC patients
#21663
high Confidence
Subject:
SPC25
(Protein coding genes)
→
is_biomarker_for
→
Object:
prognosis
(Clinical Outcomes)
Original: SPC25#functions as#a prognostic-related biomarker
#21662
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
is_located_in
→
Object:
nucleolus
(Subcellular structure)
Original: Nucleophosmin 1 (NPM1)#is predominantly located in#the nucleolus
#21661
high Confidence
Subject:
CCND1
(Protein coding genes)
→
has_oncogenic_role_in
→
Object:
human_tumors
(Disease phenotype)
Original: Cyclin D1 gene#has#an oncogenic role in human tumors
#21660
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
is_one_of
→
Object:
most_studied_nucleolar_proteins
(Nucleolar proteins)
Original: FBL#is one of#the most studied nucleolar proteins
#21659
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
is_expressed_in
→
Object:
nucleolus_of_eukaryotes
(Cellular substructure)
Original: FBL#is expressed in#the nucleolus of eukaryotes
#21658
high Confidence
Subject:
FBL_protein
(Ribosome biogenesis protein)
→
contains
→
Object:
methyltransferase_domain
(Protein domain)
Original: FBL protein#contains#GAR domain and methyltransferase domain
#21657
high Confidence
Subject:
FBL_protein
(Ribosome biogenesis protein)
→
contains
→
Object:
GAR_domain
(Protein domain)
Original: FBL protein#contains#GAR domain and methyltransferase domain
#21656
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
is_localized_in
→
Object:
dense_fibrillar_component_of_nucleolus
(Cellular substructure)
Original: FBL#is localized in#the dense fibrillar component of the nucleolus
#21655
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
is
→
Object:
nucleolar_protein
(Nucleolar proteins)
Original: Fibrillarin (FBL)#is#a highly conserved nucleolar protein
#21654
high Confidence
Subject:
CDK4
(Protein kinase)
→
phosphorylates
→
Object:
retinoblastoma_protein
(Tumor suppressor proteins)
Original: Cyclin D1#activates#cdk4 to produce retinoblastoma protein phosphorylation
#21653
high Confidence
Subject:
Cyclin_D1
(Cell cycle proteins)
→
activates
→
Object:
CDK4
(Protein kinase)
Original: Cyclin D1#activates#cdk4 to produce retinoblastoma protein phosphorylation
#21652
high Confidence
Subject:
NPM1
(Nucleolar proteins)
→
facilitates
→
Object:
ribosome_biogenesis
(Molecular complex synthesis)
Original: NPM1#facilitates#ribosome biogenesis and nucleolar stress responses
#21651
high Confidence
Subject:
Ribosome_biogenesis
(Biological Process)
→
is_initiated_in
→
Object:
nucleolus
(Cellular substructure)
Original: Ribosome biogenesis#is initiated in#nucleolus
#21650
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
is_involved_in
→
Object:
ribosome_subunit_biogenesis
(Molecular Process)
Original: Nucleolus#is involved in#ribosome subunit biogenesis/ cell cycle control/ and stress responses
#21649
high Confidence
Subject:
K562_cells
(Cell lines)
→
carry
→
Object:
bcr/abl_fusion_gene
(Fusion gene)
Original: K562 cells#carry#bcr/abl fusion gene
#21648
high Confidence
Subject:
risk_signature
(Risk Scoring Model)
→
has
→
Object:
independent_prognostic_significance
(Clinical Outcomes)
Original: Risk signature#has#independent prognostic significance for HGSOC
#21647
high Confidence
Subject:
DEN_exposure
(Environmental carcinogens)
→
induces
→
Object:
neoplasms
(Tumor)
Original: DEN exposure#induces#altered foci and neoplasms in fish
#21646
high Confidence
Subject:
DEN_exposure
(Environmental carcinogens)
→
induces
→
Object:
altered_foci
(Pathological morphology)
Original: DEN exposure#induces#altered foci and neoplasms in fish
#21645
high Confidence
Subject:
RNA_polymerase_I
(Enzymes)
→
is_a_target_of
→
Object:
novel_drugs
(Small molecule drugs)
Original: Novel drugs targeting RNA Polymerase I#are#viable targets for cancer therapies
#21644
high Confidence
Subject:
mTOR_pathway_proteins
(Signaling pathway proteins)
→
are_activated_in
→
Object:
ductal_adenocarcinoma
(Tumor type)
Original: mTOR pathway proteins#are activated in#ductal adenocarcinoma
#21643
high Confidence
Subject:
MYB
(Protein coding genes)
→
fusion_and_expression_correlate_with
→
Object:
predictors_of_outcome
(Clinical prognostic indicators)
Original: MYB fusion and protein expression#were correlated with#predictors of outcome in adenoid cystic carcinoma
#21642
high Confidence
Subject:
MYC
(Protein coding genes)
→
amplification_correlates_with
→
Object:
overexpression_of_MYC
(Protein expression)
Original: C-MYC amplification#was correlated with#overexpression of C-MYC/ TERT/ and FBL
#21641
high Confidence
Subject:
SDHB
(Protein coding genes)
→
involved_in
→
Object:
SDH_deficient_RCC
(Disease phenotype)
Original: Gene alterations#involve#SDHB subunit in SDH-deficient RCC
#21640
high Confidence
Subject:
NPM1
(Protein coding genes)
→
mutated_leads_to
→
Object:
aberrant_cytoplasmic_dislocation_of_NPM-c
(Abnormal protein localization)
Original: Mutations in NPM1#lead to#aberrant cytoplasmic dislocation of NPM-c
#21639
high Confidence
Subject:
MKI67
(Cell proliferation marker protein)
→
is_upregulated
→
Object:
PHE_tissues
(Tissue samples)
Original: Proliferation index of Ki-67#is#10-35%
#21638
high Confidence
Subject:
FGF2
(Growth factor protein)
→
is_expressed_in
→
Object:
gliomas
(Tumor tissue)
Original: Basic FGF mRNA#is expressed in#more than 90% of human gliomas
#21637
high Confidence
Subject:
EGFR
(Receptor protein)
→
inhibition_of
→
Object:
tumor_growth
(Tumor growth process)
Original: Reduction in EGF receptors#inhibits#tumor growth
#21636
high Confidence
Subject:
NPM1c+_variant
(Protein coding gene mutants)
→
causes
→
Object:
cytoplasmic_accumulation_of_APE1
(Abnormal molecular localization)
Original: Expression of NPM1c+ variant#causes#cytoplasmic accumulation of APE1 in HeLa cells/ OCI/AML3 cells/ and primary lymphoblasts
#21635
high Confidence
Subject:
MYC
(Protein coding genes)
→
amplified_in
→
Object:
chromatin_remodeling_pathway
(signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
#21634
high Confidence
Subject:
NOTCH1
(Protein coding genes)
→
mutated_in
→
Object:
chromatin_remodeling_pathway
(signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
#21633
high Confidence
Subject:
SMAD4
(Protein coding genes)
→
mutated_in
→
Object:
chromatin_remodeling_pathway
(signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
#21632
high Confidence
Subject:
DICER1
(Protein coding genes)
→
mutated_in
→
Object:
chromatin_remodeling_pathway
(signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
#21631
high Confidence
Subject:
ARID1A
(Protein coding genes)
→
mutated_in
→
Object:
chromatin_remodeling_pathway
(signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
#21630
high Confidence
Subject:
BRCA2
(Protein coding genes)
→
mutated_in
→
Object:
DNA_damage_repair_pathway
(signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
#21629
high Confidence
Subject:
BRCA1
(Protein coding genes)
→
mutated_in
→
Object:
DNA_damage_repair_pathway
(signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
#21628
high Confidence
Subject:
ATM
(Protein coding genes)
→
mutated_in
→
Object:
DNA_damage_repair_pathway
(signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
#21627
high Confidence
Subject:
TFE3
(Transcription Factors)
→
rearrangement_associates_with
→
Object:
melanotic_Xp11_neoplasms
(Tumor type)
Original: TFE3 rearrangement-associated tumors#include#PEComas/ melanotic Xp11 translocation renal cancers/ melanotic Xp11 neoplasms
#21626
high Confidence
Subject:
TFE3
(Transcription Factors)
→
rearrangement_associates_with
→
Object:
melanotic_Xp11_translocation_renal_cancers
(Tumor type)
Original: TFE3 rearrangement-associated tumors#include#PEComas/ melanotic Xp11 translocation renal cancers/ melanotic Xp11 neoplasms
#21625
high Confidence
Subject:
TFE3
(Transcription Factors)
→
rearrangement_associates_with
→
Object:
PEComas
(Tumor type)
Original: TFE3 rearrangement-associated tumors#include#PEComas/ melanotic Xp11 translocation renal cancers/ melanotic Xp11 neoplasms
#21624
high Confidence
Subject:
fusion_analysis
(Molecular detection methods)
→
is_important_for
→
Object:
ALK-based_targeted_therapy
(Targeted therapy)
Original: Fusion analysis#is important for#RET-and ALK-based targeted therapies
#21623
high Confidence
Subject:
fusion_analysis
(Molecular detection methods)
→
is_important_for
→
Object:
RET-based_targeted_therapy
(Targeted therapy)
Original: Fusion analysis#is important for#RET-and ALK-based targeted therapies
#21622
high Confidence
Subject:
targeted_next_generation_sequencing_panel
(Molecular detection technology)
→
analyzes
→
Object:
cancer-related_genes
(Gene)
Original: 1425 cancer-related genes#were analyzed using#targeted next generation sequencing panel
#21621
high Confidence
Subject:
SWI/SNF_chromatin_remodeling_complex
(Protein complex)
→
acts_as
→
Object:
tumor_suppressor
(Functional phenotype)
Original: SWI/SNF chromatin remodeling complex#has#tumor suppressor roles in human cancers
#21620
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
involved_in
→
Object:
ribosome_assembly
(Molecular complex assembly)
Original: Fibrillarin#is involved in#pre-rRNA processing/ methylation/ and ribosome assembly
#21619
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
involved_in
→
Object:
rRNA_methylation
(Molecular modification)
Original: Fibrillarin#is involved in#pre-rRNA processing/ methylation/ and ribosome assembly
#21618
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
involved_in
→
Object:
pre-rRNA_processing
(Molecular Process)
Original: Fibrillarin#is involved in#pre-rRNA processing/ methylation/ and ribosome assembly
#21617
high Confidence
Subject:
cellular_senescence
(Cellular Processes)
→
reduces
→
Object:
nucleolar_rRNA_synthesis
(Molecular Process)
Original: Cellular senescence#reduces#nucleolar rRNA synthesis and maturation
#21616
high Confidence
Subject:
silver_staining
(Molecular analysis technology)
→
was_applied_to
→
Object:
paraffin_blocked_tissue
(Tissue samples)
Original: Silver staining#was applied to#paraffin-blocked tissues from rectal cancer patients
#21615
high Confidence
Subject:
GCN2
(Protein kinase)
→
is_activated_by
→
Object:
uncharged_tRNA_accumulation
(Molecular accumulation)
Original: GCN2#is activated by#uncharged tRNA accumulation during amino acid shortage
#21614
high Confidence
Subject:
TP53BP1
(DNA damage repair proteins)
→
is_involved_in
→
Object:
DNA_damage_response
(DNA Damage Response)
Original: 53BP1 protein#is involved in#DNA damage response (DDR)
#21613
high Confidence
Subject:
TP53BP1
(DNA damage repair proteins)
→
is_upregulated_in
→
Object:
irradiated_genome
(Damaged genome)
Original: Increased levels of H2AX and 53BP1 proteins#were confirmed in#irradiated genome
#21612
high Confidence
Subject:
H2AX
(Histone variants)
→
is_upregulated_in
→
Object:
irradiated_genome
(Damaged genome)
Original: Increased levels of H2AX and 53BP1 proteins#were confirmed in#irradiated genome
#21611
high Confidence
Subject:
Ki-67 Antibody
(Antibody)
→
are_used_as
→
Object:
prognostic_tools
(Diagnostic Tools)
Original: Antibodies against Ki-67 protein#are used as#prognostic tools in cancer patient biopsies
#21610
high Confidence
Subject:
p53
(Transcription Factors)
→
leads_to
→
Object:
apoptosis
(Apoptosis)
Original: Accumulation of p53#leads to#cell cycle arrest or apoptosis
#21609
high Confidence
Subject:
p53
(Transcription Factors)
→
leads_to
→
Object:
cell_cycle_arrest
(Cell cycle arrest)
Original: Accumulation of p53#leads to#cell cycle arrest or apoptosis
#21608
high Confidence
Subject:
PML
(Tumor suppressor proteins)
→
sequesters
→
Object:
MDM2_to_nucleolus
(Protein localization)
Original: PML#sequesters#Mdm2 to the nucleolus
#21607
high Confidence
Subject:
PML
(Tumor suppressor proteins)
→
interacts_with
→
Object:
MDM2
(Ubiquitin ligase)
Original: PML#interacts with#p53 ubiquitin-ligase Mdm2
#21606
high Confidence
Subject:
TP53
(Transcription Factors)
→
is_a
→
Object:
nucleocytoplasmic_shuttling_protein
(Protein function)
Original: Tumor suppressor p53#is a#nucleocytoplasmic shuttling protein
#21605
high Confidence
Subject:
MMP2
(Protease)
→
regulates
→
Object:
cell_proliferation
(Cellular Processes)
Original: Matrix metalloproteinase-2#regulates#cell proliferation through histone clipping and facilitation of ribosomal RNA transcription
#21604
high Confidence
Subject:
ribosomal_RNA_genes
(Genomic DNA sequence)
→
are_located_in
→
Object:
nucleolus
(Cellular substructure)
Original: Genes encoding ribosomal RNA#are located in#the nucleolus
#21603
high Confidence
Subject:
Nucleic_acid_binding_domains
(Protein domain)
→
are_targeted_by
→
Object:
autoantibodies_in_SLE
(Autoantibodies)
Original: Nucleic acid-binding domains#are targeted by#autoantibodies in SLE
#21602
high Confidence
Subject:
Topo_I_N-terminal_domain
(Protein domain)
→
is_fused_to
→
Object:
EGFP
(Fluorescent Protein)
Original: Topo I N-terminal domain#is fused to#enhanced green fluorescent protein (EGFP)
#21601
high Confidence
Subject:
NPM_C-terminal_mutation
(Gene mutation)
→
is_associated_with
→
Object:
better_outcome_of_AML_therapy
(Clinical Outcomes)
Original: Mutations in C-terminal part of NPM#are associated with#better outcome of AML therapy
#21600
high Confidence
Subject:
nucleolar_number
(Cellular substructure)
→
is_recognized_as
→
Object:
tumor_hallmark
(Disease phenotype)
Original: Larger nucleolar size and number#are recognized as#hallmark features of many tumor types
#21599
high Confidence
Subject:
nucleolar_size
(Cellular substructure)
→
is_recognized_as
→
Object:
tumor_hallmark
(Disease phenotype)
Original: Larger nucleolar size and number#are recognized as#hallmark features of many tumor types
#21598
high Confidence
Subject:
microRNAs
(MicroRNA)
→
play_key_roles_in
→
Object:
tumor_biology
(Tumor Biology)
Original: microRNAs (miRNAs)#play#key roles in development/ cell proliferation/ apoptosis/ and tumor biology
#21597
high Confidence
Subject:
microRNAs
(MicroRNA)
→
play_key_roles_in
→
Object:
apoptosis
(Apoptosis)
Original: microRNAs (miRNAs)#play#key roles in development/ cell proliferation/ apoptosis/ and tumor biology
#21596
high Confidence
Subject:
microRNAs
(MicroRNA)
→
play_key_roles_in
→
Object:
cell_proliferation
(Cell proliferation)
Original: microRNAs (miRNAs)#play#key roles in development/ cell proliferation/ apoptosis/ and tumor biology
#21595
high Confidence
Subject:
microRNAs
(MicroRNA)
→
play_key_roles_in
→
Object:
development
(Developmental process)
Original: microRNAs (miRNAs)#play#key roles in development/ cell proliferation/ apoptosis/ and tumor biology
#21594
high Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar organizing region)
→
contain
→
Object:
nonhistone_proteins
(Non-histone proteins)
Original: nucleolar organizer regions#contain#nonhistone proteins
#21593
high Confidence
Subject:
nucleolus
(Organelles)
→
fulfills
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: nucleolus#fulfills#crucial functions in ribosome biogenesis
#21592
high Confidence
Subject:
ALK_phosphorylation
(Protein kinase modification)
→
drives
→
Object:
systemic_ALCL_pathogenesis
(Disease progression)
Original: Phosphorylation of ALK tyrosine kinase#drives#systemic ALCL pathogenesis
#21591
high Confidence
Subject:
rRNA_biogenesis
(Molecular Process)
→
activates
→
Object:
p53
(Tumor suppressor proteins)
Original: Disruption of rRNA biogenesis#activates#p53 by release of ribosomal proteins from nucleoli
#21590
high Confidence
Subject:
DCAF13
(Ubiquitin ligase)
→
enhances
→
Object:
cell_proliferation
(Cell proliferation)
Original: DCAF13#enhances#Pol I transcription and proliferation in BC cells
#21589
high Confidence
Subject:
DCAF13
(Ubiquitin ligase)
→
enhances
→
Object:
Pol_I_transcription
(Transcriptional activity)
Original: DCAF13#enhances#Pol I transcription and proliferation in BC cells
#21588
high Confidence
Subject:
assembly_and_maturation_factors
(Ribosome assembly factor)
→
are_upregulated_in
→
Object:
Breast_Cancer
(disease)
Original: Assembly and maturation factors (AMFs)#are upregulated in#Breast Cancer
#21587
high Confidence
Subject:
K63-linked_ubiquitination_of_POLR1A
(Protein modification)
→
promotes
→
Object:
uncontrolled_proliferation
(Cell proliferation)
Original: DCAF13-mediated K63-linked ubiquitination of RNA polymerase I#promotes#uncontrolled proliferation in Breast Cancer
#21586
high Confidence
Subject:
DCAF13
(Ubiquitin ligase)
→
mediates
→
Object:
K63-linked_ubiquitination_of_POLR1A
(Protein modification)
Original: DCAF13-mediated K63-linked ubiquitination of RNA polymerase I#promotes#uncontrolled proliferation in Breast Cancer
#21585
high Confidence
Subject:
c-Myc
(Transcription Factors)
→
regulates
→
Object:
cell_proliferation
(Cell proliferation)
Original: c-Myc#regulates#ribosomal RNA synthesis/ ribosome biogenesis/ and cell proliferation
#21584
high Confidence
Subject:
c-Myc
(Transcription Factors)
→
regulates
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: c-Myc#regulates#ribosomal RNA synthesis/ ribosome biogenesis/ and cell proliferation
#21583
high Confidence
Subject:
c-Myc
(Transcription Factors)
→
regulates
→
Object:
ribosomal_RNA_synthesis
(Ribosomal RNA synthesis)
Original: c-Myc#regulates#ribosomal RNA synthesis/ ribosome biogenesis/ and cell proliferation
#21582
high Confidence
Subject:
ECT2
(Guanine nucleotide exchange factor)
→
promotes
→
Object:
cancer_cell_proliferation
(Cell proliferation)
Original: ECT2#promotes#cancer cell proliferation
#21581
high Confidence
Subject:
miRNA
(Noncoding RNA)
→
undergoes
→
Object:
multistep_biogenesis
(RNA biosynthesis process)
Original: MicroRNAs (miRNA)#undergo#a multistep biogenesis
#21580
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
sensitizes
→
Object:
tumor_cells_to_DNA_crosslinking_agents
(Cellular drug sensitivity)
Original: Knockdown of FBL#sensitizes#tumor cells to DNA crosslinking agents
#21579
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
is_responsible_for
→
Object:
methylation_of_ribosomal_RNA
(Molecular modification)
Original: Fibrillarin (FBL)#is responsible for#methylation of ribosomal RNA and proteins
#21578
high Confidence
Subject:
ribosomal_stress
(Cellular stress)
→
triggers
→
Object:
p53_signaling_pathway_activation
(Signaling pathway activation)
Original: Ribosomal stress#triggers#p53 signaling pathway activation via RPs-MDM2 interactions
#21577
high Confidence
Subject:
Ribosomal_proteins
(Ribosomal proteins)
→
activates
→
Object:
p53
(Transcription Factors)
Original: Ribosomal proteins (RPs)#activate#p53 tumor-suppressor protein upon nucleolus disruption
#21576
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
is_involved_in
→
Object:
ribosome_biogenesis
(Molecular Process)
Original: The nucleolus#is involved in#ribosomal RNA synthesis/ ribosome biogenesis/ and stress response
#21575
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
is_involved_in
→
Object:
ribosomal_RNA_synthesis
(Molecular Process)
Original: The nucleolus#is involved in#ribosomal RNA synthesis/ ribosome biogenesis/ and stress response
#21574
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
is
→
Object:
nuclear_subcompartment_for_ribosome_subunit_biogenesis
(Subcellular structure function)
Original: Nucleolus#is#a nuclear subcompartment for rRNA production and ribosome subunit biogenesis
#21573
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
is
→
Object:
nuclear_subcompartment_for_rRNA_production
(Subcellular structure function)
Original: Nucleolus#is#a nuclear subcompartment for rRNA production and ribosome subunit biogenesis
#21572
high Confidence
Subject:
puromycin_aminonucleoside
(Small molecule drugs)
→
selectively_inhibits
→
Object:
ribosomal_RNA_synthesis
(rRNA synthesis)
Original: Puromycin aminonucleoside#selectively inhibits#synthesis of ribosomal RNA
#21571
high Confidence
Subject:
nucleolus
(Organelles)
→
is_responsible_for
→
Object:
ribosomal_subunit_transcription
(Ribosomal subunit transcription)
Original: Nucleolus#is responsible for#transcription and assembly of ribosome subunits
#21570
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
cell_proliferation
(Cell proliferation)
Original: NCL#is involved in#cell proliferation
#21569
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: NCL#is involved in#ribosome biogenesis
#21568
high Confidence
Subject:
Niraparib
(PARP inhibitors)
→
inhibits
→
Object:
PARP1-mediated_ADPRylation_of_DDX21
(Protein modification)
Original: Inhibition of PARP1-mediated ADPRylation of DDX21 by niraparib#mislocalizes#DDX21 to nucleoplasm
#21567
high Confidence
Subject:
CX5461
(Small molecule inhibitors)
→
targets
→
Object:
RNAPOL1
(RNA polymerase)
Original: CX5461#disrupts#nucleolar integrity by targeting RNAPOL1
#21566
high Confidence
Subject:
MDM2
(Ubiquitin ligase)
→
binds_to
→
Object:
RPL11
(Ribosomal proteins)
Original: RPL11#binds#MDM2 to centralize the nucleolar stress-sensing pathway
#21565
high Confidence
Subject:
RPL11
(Ribosomal proteins)
→
binds_to
→
Object:
MDM2
(Ubiquitin ligase)
Original: RPL11#binds#MDM2 to centralize the nucleolar stress-sensing pathway
#21564
high Confidence
Subject:
ribosome_biogenesis
(Ribosome biogenesis)
→
disruption_kills
→
Object:
tumor_cells
(cancer cell)
Original: Disruption of ribosome biogenesis#kills#tumor cells via nucleolar function disruption
#21563
high Confidence
Subject:
cancer_cells
(cancer cell)
→
exhibit
→
Object:
increased_ribosome_biogenesis
(Ribosome biogenesis)
Original: Cancer cells#exhibit#large nucleoli and increased ribosome biogenesis
#21562
high Confidence
Subject:
cancer_cells
(cancer cell)
→
exhibit
→
Object:
large_nucleoli
(Cellular substructure)
Original: Cancer cells#exhibit#large nucleoli and increased ribosome biogenesis
#21561
high Confidence
Subject:
SGO2
(Protein coding genes)
→
is_overexpressed_in
→
Object:
Cancer
(Tumor type)
Original: SGO2#is found to be#overexpressed in 25 of 33 cancer types/ including LUAD
#21560
high Confidence
Subject:
SGO2
(Protein coding genes)
→
is_overexpressed_in
→
Object:
LUAD
(Tumor type)
Original: SGO2#is found to be#overexpressed in 25 of 33 cancer types/ including LUAD
#21559
high Confidence
Subject:
Ki-67
(Cell proliferation markers)
→
parallels
→
Object:
cell_proliferation
(Cellular Processes)
Original: Ki-67 expression#paralleled#cell proliferation in fibroblasts and lymphocytes
#21558
high Confidence
Subject:
Ki-67
(Cell proliferation markers)
→
parallels
→
Object:
cell_proliferation
(Cellular Processes)
Original: Ki-67 expression#paralleled#cell proliferation in fibroblasts and lymphocytes
#21557
high Confidence
Subject:
ALK
(Tyrosine kinase)
→
is_activated_through
→
Object:
chromosomal_translocation_with_NPM
(Genomic abnormalities)
Original: ALK#is activated through#chromosomal translocations with NPM
#21556
high Confidence
Subject:
AOM
(Chemical carcinogens)
→
induces
→
Object:
colonic_aberrant_crypt_foci
(Pathological process)
Original: AOM#induced#colonic aberrant crypt foci in rats
#21555
high Confidence
Subject:
NOP16
(Ribosomal proteins)
→
is_primarily_expressed_in
→
Object:
T_lymphocytes
(Immune cells)
Original: LIHC scRNA-seq data#showed#NOP16 was primarily expressed in T lymphocytes
#21554
high Confidence
Subject:
protein
(protein)
→
is_member_of
→
Object:
DEAD-box_family
(Protein family)
Original: Protein#is a member of#DEAD-box family
#21553
high Confidence
Subject:
DHODH
(Enzymes)
→
inhibition_depletes
→
Object:
pyrimidine_pool
(Metabolites)
Original: Pharmacological inhibition of DHODH#depleted#the pool of pyrimidines in glioblastoma cells
#21552
high Confidence
Subject:
DDX21_knockdown
(Genetic intervention)
→
reduces
→
Object:
tumorigenicity
(Tumorigenicity)
Original: DDX21 knockdown#reduces#tumorigenicity in vitro and in vivo
#21551
high Confidence
Subject:
DDX21_knockdown
(Genetic intervention)
→
induces
→
Object:
apoptosis_in_tumor_cells
(Cellular Processes)
Original: DDX21 knockdown#induces#apoptosis in tumor cells
#21550
high Confidence
Subject:
Actinomycin_D
(Antibiotics)
→
inhibits
→
Object:
rRNA_synthesis
(Molecular Process)
Original: Actinomycin D#inhibits#rRNA synthesis
#21549
high Confidence
Subject:
Bleomycin
(Anticancer drugs)
→
inhibits
→
Object:
DNA_synthesis
(Molecular Process)
Original: Bleomycin#inhibits#DNA synthesis
#21548
high Confidence
Subject:
EMP3
(Membrane Protein)
→
expression_verified_by
→
Object:
qPCR
(Detection Technology)
Original: Western blot and qPCR#verified#expression of EMP3 in ccRCC tissues and cell lines
#21547
high Confidence
Subject:
EMP3
(Membrane Protein)
→
expression_verified_by
→
Object:
Western_blot
(Detection Technology)
Original: Western blot and qPCR#verified#expression of EMP3 in ccRCC tissues and cell lines
#21546
high Confidence
Subject:
AgNOR_score
(Histological markers)
→
is_significantly_higher_in
→
Object:
pancreatic_carcinoma_tissue
(Tumor tissue)
Original: Ag-NOR score#is significantly higher in#pancreatic carcinoma tissues compared to normal pancreatic tissues
#21545
high Confidence
Subject:
Adenomatous_hyperplasia
(Adenomatous hyperplasia)
→
is_considered
→
Object:
preneoplastic_lesion_in_liver
(Precancerous lesions of the liver)
Original: Adenomatous hyperplasia (AH)#is considered#a preneoplastic lesion in the liver
#21544
high Confidence
Subject:
cytological_examination
(Cytology)
→
distinguishes
→
Object:
malignant_cases
(Malignant cases)
Original: cytological examination#distinguishes#benign from malignant cases
#21543
high Confidence
Subject:
cytological_examination
(Cytology)
→
distinguishes
→
Object:
benign_cases
(Benign cases)
Original: cytological examination#distinguishes#benign from malignant cases
#21542
high Confidence
Subject:
HER2_gene_amplification
(Gene amplification)
→
is_evaluated_by
→
Object:
FISH
(Molecular analysis technology)
Original: HER-2/neu gene amplification#is evaluated by#FISH
#21541
high Confidence
Subject:
Barretts_esophagus
(disease)
→
increases_risk_of
→
Object:
carcinoma
(disease)
Original: Barrett's esophagus (BE)#increases risk of#carcinoma
#21540
high Confidence
Subject:
AgNORs
(Nucleolar organizer region)
→
are_crucial_for
→
Object:
prediction_of_clinical_course_and_aggressiveness_of_tumors
(Prediction of clinical progression of tumors)
Original: AgNORs#are crucial for#predicting the clinical course and aggressiveness of tumors
#21539
high Confidence
Subject:
grading_of_breast_carcinoma
(Tumor grade)
→
is_helpful_in
→
Object:
selection_of_patients_for_appropriate_therapy
(Treatment options)
Original: grading of breast carcinoma#is helpful in#selecting patients for appropriate therapy
#21538
high Confidence
Subject:
HPD
(protein)
→
positively_correlates_with
→
Object:
clinical_stage
(Clinical staging)
Original: HPD expression level#is positively correlated with#histological grade and clinical stage in breast cancer
#21537
high Confidence
Subject:
HPD
(protein)
→
positively_correlates_with
→
Object:
histological_grade
(Pathological grading)
Original: HPD expression level#is positively correlated with#histological grade and clinical stage in breast cancer
#21536
high Confidence
Subject:
prostate_cancers
(Tumor)
→
are_classified_by
→
Object:
Gleason's_histological_grades
(Pathological grading)
Original: Prostate cancers#are classified by#Gleason's histological grades
#21535
high Confidence
Subject:
NCL
(Nucleolin)
→
is_promising_target_for
→
Object:
treatment_of_gastric_cancer
(Clinical treatment)
Original: nucleolin on cell surface#is a promising target for#treatment of gastric cancer
#21534
high Confidence
Subject:
Immunohistochemical staining
(Histological techniques)
→
labels
→
Object:
Tumor cell nucleus
(Cellular substructure)
Original: Immunohistochemical staining with Ki-67#produced#clear labeling of tumor cell nuclei
#21533
high Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar organizing region)
→
contain
→
Object:
ribosomal_RNA_genes
(rRNA gene)
Original: Nucleolar organizer regions#contain#ribosomal RNA genes
#21532
high Confidence
Subject:
AgNORs
(Nucleolar Organizing Region Marker)
→
is_lower_in
→
Object:
surgical_patients_surviving_over_5_years
(Clinical Outcome (Long-term Survival))
Original: PI and AgNORs image analysis results#are significantly lower in#surgical patients surviving over 5 years compared to those surviving less than 3 years
#21531
high Confidence
Subject:
proliferation_index
(Proliferation activity index)
→
is_lower_in
→
Object:
surgical_patients_surviving_over_5_years
(Clinical Outcome (Long-term Survival))
Original: PI and AgNORs image analysis results#are significantly lower in#surgical patients surviving over 5 years compared to those surviving less than 3 years
#21530
high Confidence
Subject:
FDG-PET
(Molecular imaging technology)
→
has_diagnostic_significance_in
→
Object:
oral_squamous_cell_carcinoma
(disease)
Original: FDG-PET and AgNORs#have diagnostic significance in#oral squamous cell carcinoma
#21529
high Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar structure)
→
contain
→
Object:
tandemly_arranged_18S_28S_rRNA_genes
(rRNA gene)
Original: Nucleolar organizer regions (NORs)#contain#tandemly arranged repeats for 18S and 28S rRNA genes
#21528
high Confidence
Subject:
seminal_vesicle_epithelium
(Seminal vesicle epithelium)
→
can_be_pitfall_in
→
Object:
cytologic_diagnosis
(Cytological diagnosis)
Original: Seminal vesicle epithelium#can be a pitfall in#the cytologic diagnosis of carcinoma
#21527
high Confidence
Subject:
genetic_studies
(Genetic research)
→
need_to_be_performed_on
→
Object:
ocular_melanomas
(Ocular Melanoma)
Original: genetic studies#need to be performed on#cutaneous/ mucosal/ or ocular melanomas
#21526
high Confidence
Subject:
genetic_studies
(Genetic research)
→
need_to_be_performed_on
→
Object:
mucosal_melanomas
(Mucosal melanoma)
Original: genetic studies#need to be performed on#cutaneous/ mucosal/ or ocular melanomas
#21525
high Confidence
Subject:
genetic_studies
(Genetic research)
→
need_to_be_performed_on
→
Object:
cutaneous_melanomas
(Skin melanoma)
Original: genetic studies#need to be performed on#cutaneous/ mucosal/ or ocular melanomas
#21524
high Confidence
Subject:
cytologic_findings_in_FNAB
(Fine needle aspiration cytology findings)
→
are_reported_for
→
Object:
clear_cell_sarcoma_of_kidney
(Clear cell sarcoma of the kidney)
Original: Cytologic findings in FNAB#are reported for#clear-cell sarcoma of the kidney
#21523
high Confidence
Subject:
adenomatoid_tumor
(Adenomatous tumor)
→
arises_from
→
Object:
testicular_tunica_albuginea
(Testicular tunica albuginea)
Original: Adenomatoid tumor#arises from#testicular tunica albuginea
#21522
high Confidence
Subject:
monocytoid_B_cell_lymphoma
(Monocytic B-cell lymphoma)
→
is_often_diagnosed_in
→
Object:
lymph_node_phase_low_stages
(Lymph node stage low)
Original: Monocytoid B-cell lymphoma#is often diagnosed in#lymph-node phase/ low stages (I-II)
#21521
high Confidence
Subject:
squamous_metaplasia
(Squamous metaplasia)
→
is_valuable_adjunct_to
→
Object:
cytomorphologic_changes
(Cell morphological changes)
Original: Squamous metaplasia#is a valuable adjunct to#cytomorphologic changes like nucleoli size decrease in hormonal therapy response
#21520
high Confidence
Subject:
chemotherapeutic_effects
(Chemotherapy effect)
→
were_assessed_using
→
Object:
nucleolar_presence
(Nucleolus exists)
Original: Recurrent neoplasm and chemotherapeutic effects#were assessed using#nucleolar presence and other criteria
#21519
high Confidence
Subject:
recurrent_neoplasm
(Recurrent tumors)
→
were_assessed_using
→
Object:
nucleolar_presence
(Nucleolus exists)
Original: Recurrent neoplasm and chemotherapeutic effects#were assessed using#nucleolar presence and other criteria
#21518
high Confidence
Subject:
HLRCC
(Hereditary tumor syndrome)
→
shows
→
Object:
partial_cystic_area
(Some cystic areas)
Original: HLRCC arising in the kidney#shows#a solid tumor with frequent partial cystic area
#21517
high Confidence
Subject:
HLRCC
(Hereditary tumor syndrome)
→
shows
→
Object:
solid_tumor
(Solid Tumors)
Original: HLRCC arising in the kidney#shows#a solid tumor with frequent partial cystic area
#21516
high Confidence
Subject:
renal_eAML_PEComa
(Renal eAML/PEComa)
→
displayed
→
Object:
TFE3_gene_break_by_FISH
(TFE3 gene disruption)
Original: Renal eAML/PEComa#displayed#a TFE3 gene break visible by FISH
#21515
high Confidence
Subject:
biopsy_specimen
(Biopsy specimen)
→
confirmed
→
Object:
diagnosis_of_BL
(Burkitt Lymphoma Diagnosis)
Original: Biopsy specimens#confirmed#the diagnosis of BL
#21514
high Confidence
Subject:
final_diagnosis_of_UC_of_gall_bladder
(Diagnostic Events)
→
requires
→
Object:
careful_analysis_of_histological_and_immunophenotypic_features
(Diagnostic analysis)
Original: final diagnosis of UC of the gall bladder#requires#careful analysis of histological and immunophenotypic features
#21513
high Confidence
Subject:
Adenomatoid_tumor
(Tumor type)
→
is
→
Object:
primary_neoplasm_of_paratesticular_area
(Tumor classification)
Original: Adenomatoid tumor#is#one of the most common primary neoplasms of the paratesticular area
#21512
high Confidence
Subject:
Malignant_rhabdoid_tumor
(Tumor type)
→
frequently_occurs_in
→
Object:
kidney
(organ)
Original: MRT#frequently occurs in#the kidney
#21511
high Confidence
Subject:
tumor
(Tumor tissue)
→
shows
→
Object:
papillary_RCC_type_2
(Tumor classification)
Original: The tumor#typically shows#papillary RCC/ type 2/ with eosinophilic large nucleoli and perinuclear clearing/haloes
#21510
high Confidence
Subject:
Nuclear_parameters
(Nuclear parameters)
→
are_valuable_discriminants_between
→
Object:
renal_oncocytoma
(Tumor type)
Original: Nuclear parameters#are valuable discriminants between#chromophobe renal cell carcinoma and renal oncocytoma
#21509
high Confidence
Subject:
Nuclear_parameters
(Nuclear parameters)
→
are_valuable_discriminants_between
→
Object:
chromophobe_renal_cell_carcinoma
(Tumor type)
Original: Nuclear parameters#are valuable discriminants between#chromophobe renal cell carcinoma and renal oncocytoma
#21508
high Confidence
Subject:
Primary_cutaneous_diffuse_large_B-cell_lymphoma
(Tumor)
→
accounts_for
→
Object:
4_percent_of_all_primary_cutaneous_lymphomas
(Epidemiological data)
Original: Primary cutaneous diffuse large B-cell lymphoma#accounts for#4% of all primary cutaneous lymphomas
#21507
high Confidence
Subject:
MAPK/ERK_pathway_mutations
(Signaling pathway mutations)
→
are_indicative_of
→
Object:
clonal_process
(Cellular Processes)
Original: MAPK/ERK pathway mutations#are indicative of#a clonal process
#21506
high Confidence
Subject:
melanoma
(Tumor type)
→
originates_from
→
Object:
melanocytes
(Cell Type)
Original: melanoma#originates from#melanocytes
#21505
high Confidence
Subject:
Solid pseudopapillary tumor (SPT)
(Solid tumors)
→
most_frequently_occurs_in
→
Object:
young_women
(Demographic characteristics)
Original: Solid pseudopapillary tumor (SPT)#most frequently occurs in#young women
#21504
high Confidence
Subject:
Nasopharyngeal_carcinoma
(Malignant tumors)
→
may_be_divided_into
→
Object:
Undifferentiated_carcinoma
(Histopathological type)
Original: Tumors#may be divided into#differentiated and undifferentiated carcinoma
#21503
high Confidence
Subject:
Nasopharyngeal_carcinoma
(Malignant tumors)
→
may_be_divided_into
→
Object:
Differentiated_carcinoma
(Histopathological type)
Original: Tumors#may be divided into#differentiated and undifferentiated carcinoma
#21502
high Confidence
Subject:
tumor
(Tumor)
→
was_curatively_resected_by
→
Object:
surgery
(Surgery)
Original: The tumor#was curatively resected#via surgery
#21501
high Confidence
Subject:
call-exner_body
(Organizational Structure)
→
is_characteristic_of
→
Object:
ovarian_tumor
(Tumor)
Original: Call-Exner's Bodies#are characteristic of#these tumors
#21500
high Confidence
Subject:
prominent_nucleoli
(Cell structure)
→
is_identified_as
→
Object:
independent_risk_factor_for_disease-free_survival
(Clinical Outcomes)
Original: The presence of prominent nucleoli#was identified as#an independent risk factor for disease-free survival
#21499
high Confidence
Subject:
high_clinical_stage
(Clinical staging)
→
is_identified_as
→
Object:
independent_risk_factor_for_disease-free_survival
(Clinical Outcomes)
Original: High clinical stage#was identified as#an independent risk factor for disease-free survival
#21498
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
strongly_express
→
Object:
MITF
(Transcription Factors)
Original: Tumor cells#strongly expressed#S100 protein/ gp100/ microphthalmia transcription factor
#21497
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
strongly_express
→
Object:
gp100
(protein)
Original: Tumor cells#strongly expressed#S100 protein/ gp100/ microphthalmia transcription factor
#21496
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
strongly_express
→
Object:
S100_protein
(protein)
Original: Tumor cells#strongly expressed#S100 protein/ gp100/ microphthalmia transcription factor
#21495
high Confidence
Subject:
Immunostains
(Diagnostic techniques)
→
showed_reactivity_with
→
Object:
Thyroglobulin
(Thyroglobulin)
Original: immunostains#showed reactivity with#thyroglobulin
#21494
high Confidence
Subject:
FNA_smears
(Cytology)
→
reveal
→
Object:
lymphocytes
(Immune cells)
Original: FNA smears#reveal#numerous CD1a+ and S-100+ Langerhans-type cells (LCs) along with eosinophils/ neutrophils/ and lymphocytes
#21493
high Confidence
Subject:
FNA_smears
(Cytology)
→
reveal
→
Object:
neutrophils
(Immune cells)
Original: FNA smears#reveal#numerous CD1a+ and S-100+ Langerhans-type cells (LCs) along with eosinophils/ neutrophils/ and lymphocytes
#21492
high Confidence
Subject:
FNA_smears
(Cytology)
→
reveal
→
Object:
Eosinophils
(Immune cells)
Original: FNA smears#reveal#numerous CD1a+ and S-100+ Langerhans-type cells (LCs) along with eosinophils/ neutrophils/ and lymphocytes
#21491
high Confidence
Subject:
FNA_smears
(Cytology)
→
reveal
→
Object:
S-100_positive_Langerhans-type_cells
(Immune cells)
Original: FNA smears#reveal#numerous CD1a+ and S-100+ Langerhans-type cells (LCs) along with eosinophils/ neutrophils/ and lymphocytes
#21490
high Confidence
Subject:
FNA_smears
(Cytology)
→
reveal
→
Object:
CD1a_positive_Langerhans-type_cells
(Immune cells)
Original: FNA smears#reveal#numerous CD1a+ and S-100+ Langerhans-type cells (LCs) along with eosinophils/ neutrophils/ and lymphocytes
#21489
high Confidence
Subject:
Diagnostic_smears
(Diagnostic techniques)
→
showed
→
Object:
suspicious_results_in_endometrial_cytology
(Diagnosis)
Original: Diagnostic smears#showed#positive and suspicious results in vaginal/ cervical/ and endometrial cytology
#21488
high Confidence
Subject:
Diagnostic_smears
(Diagnostic techniques)
→
showed
→
Object:
suspicious_results_in_cervical_cytology
(Diagnosis)
Original: Diagnostic smears#showed#positive and suspicious results in vaginal/ cervical/ and endometrial cytology
#21487
high Confidence
Subject:
Diagnostic_smears
(Diagnostic techniques)
→
showed
→
Object:
suspicious_results_in_vaginal_cytology
(Diagnosis)
Original: Diagnostic smears#showed#positive and suspicious results in vaginal/ cervical/ and endometrial cytology
#21486
high Confidence
Subject:
Diagnostic_smears
(Diagnostic techniques)
→
showed
→
Object:
positive_results_in_endometrial_cytology
(Diagnosis)
Original: Diagnostic smears#showed#positive and suspicious results in vaginal/ cervical/ and endometrial cytology
#21485
high Confidence
Subject:
Diagnostic_smears
(Diagnostic techniques)
→
showed
→
Object:
positive_results_in_cervical_cytology
(Diagnosis)
Original: Diagnostic smears#showed#positive and suspicious results in vaginal/ cervical/ and endometrial cytology
#21484
high Confidence
Subject:
Diagnostic_smears
(Diagnostic techniques)
→
showed
→
Object:
positive_results_in_vaginal_cytology
(Diagnosis)
Original: Diagnostic smears#showed#positive and suspicious results in vaginal/ cervical/ and endometrial cytology
#21483
high Confidence
Subject:
Abdominal_ultrasonography
(Imaging technology)
→
revealed
→
Object:
normal_findings
(Imaging findings)
Original: Computerized tomography/ gallium scintigraphy/ and abdominal ultrasonography#revealed#normal findings
#21482
high Confidence
Subject:
Gallium_scintigraphy
(Imaging technology)
→
revealed
→
Object:
normal_findings
(Imaging findings)
Original: Computerized tomography/ gallium scintigraphy/ and abdominal ultrasonography#revealed#normal findings
#21481
high Confidence
Subject:
Computerized_tomography
(Imaging technology)
→
revealed
→
Object:
normal_findings
(Imaging findings)
Original: Computerized tomography/ gallium scintigraphy/ and abdominal ultrasonography#revealed#normal findings
#21480
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
positive_for
→
Object:
synaptophysin
(Neuroendocrine markers)
Original: Tumor cells#were positive for#EMA/ CK AE1/AE3/ chromogranin/ synaptophysin
#21479
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
positive_for
→
Object:
Chromogranin
(Neuroendocrine markers)
Original: Tumor cells#were positive for#EMA/ CK AE1/AE3/ chromogranin/ synaptophysin
#21478
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
positive_for
→
Object:
CK_AE1/AE3
(Cytokeratin)
Original: Tumor cells#were positive for#EMA/ CK AE1/AE3/ chromogranin/ synaptophysin
#21477
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
positive_for
→
Object:
EMA
(Epithelial membrane antigen)
Original: Tumor cells#were positive for#EMA/ CK AE1/AE3/ chromogranin/ synaptophysin
#21476
high Confidence
Subject:
tissue
(organize)
→
expressed
→
Object:
CD79a
(Membrane Protein)
Original: Tissue#expressed#vimentin/ LCA/ CD10/ CD20/ CD38/ Bcl-2/ MUC-1/ CD79a
#21475
high Confidence
Subject:
tissue
(organize)
→
expressed
→
Object:
MUC-1
(Glycoprotein)
Original: Tissue#expressed#vimentin/ LCA/ CD10/ CD20/ CD38/ Bcl-2/ MUC-1/ CD79a
#21474
high Confidence
Subject:
tissue
(organize)
→
expressed
→
Object:
Bcl-2
(Anti-apoptotic proteins)
Original: Tissue#expressed#vimentin/ LCA/ CD10/ CD20/ CD38/ Bcl-2/ MUC-1/ CD79a
#21473
high Confidence
Subject:
tissue
(organize)
→
expressed
→
Object:
CD38
(Membrane Protein)
Original: Tissue#expressed#vimentin/ LCA/ CD10/ CD20/ CD38/ Bcl-2/ MUC-1/ CD79a
#21472
high Confidence
Subject:
tissue
(organize)
→
expressed
→
Object:
CD20
(Membrane Protein)
Original: Tissue#expressed#vimentin/ LCA/ CD10/ CD20/ CD38/ Bcl-2/ MUC-1/ CD79a
#21471
high Confidence
Subject:
tissue
(organize)
→
expressed
→
Object:
CD10
(Membrane Protein)
Original: Tissue#expressed#vimentin/ LCA/ CD10/ CD20/ CD38/ Bcl-2/ MUC-1/ CD79a
#21470
high Confidence
Subject:
tissue
(organize)
→
expressed
→
Object:
LCA
(common leukocyte antigen)
Original: Tissue#expressed#vimentin/ LCA/ CD10/ CD20/ CD38/ Bcl-2/ MUC-1/ CD79a
#21469
high Confidence
Subject:
tissue
(organize)
→
expressed
→
Object:
vimentin
(Intermediate filament protein)
Original: Tissue#expressed#vimentin/ LCA/ CD10/ CD20/ CD38/ Bcl-2/ MUC-1/ CD79a
#21468
high Confidence
Subject:
biopsy
(Tissue biopsy)
→
facilitates
→
Object:
definite_diagnosis
(Diagnosis conclusion)
Original: Biopsy#is recommended for#suspected cases to facilitate definite diagnosis
#21467
high Confidence
Subject:
biopsy
(Tissue biopsy)
→
is_recommended_for
→
Object:
suspected_cases
(Clinical Cases)
Original: Biopsy#is recommended for#suspected cases to facilitate definite diagnosis
#21466
high Confidence
Subject:
HMWCK
(Protein markers)
→
is_analyzed_by
→
Object:
Immunohistochemistry
(Molecular detection technology)
Original: Immunohistochemistry for high-molecular-weight cytokeratin (HMWCK)#was performed on#cases with available material
#21465
high Confidence
Subject:
podophyllin
(Anticancer drugs)
→
treats
→
Object:
condylomata_acuminata
(Virus-related diseases)
Original: Some changes#have been described in#condylomata acuminata treated with topical applications of podophyllin
#21464
high Confidence
Subject:
TCV
(Tumor subtype)
→
can_be_diagnosed_by
→
Object:
thyroid_FNA
(Cytology)
Original: TCV#can be effectively diagnosed#on thyroid fine-needle aspiration (FNA)
#21463
high Confidence
Subject:
partial_atrophy
(Histopathological changes)
→
is_diagnosed_as
→
Object:
atypical_glands
(Pathological structure)
Original: 170 cases with partial atrophy#were diagnosed as#atypical glands by outside pathologists
#21462
high Confidence
Subject:
CD8
(T cell surface molecules)
→
is_expressed_on
→
Object:
T_cells
(Immune cells)
Original: Flow cytometry#showed#surface expression of CD2/ CD3/ CD7 (dim)/ CD8/ and CD56
#21461
high Confidence
Subject:
CD3
(T cell surface molecules)
→
is_expressed_on
→
Object:
T_cells
(Immune cells)
Original: Flow cytometry#showed#surface expression of CD2/ CD3/ CD7 (dim)/ CD8/ and CD56
#21460
high Confidence
Subject:
CD2
(T cell surface molecules)
→
is_expressed_on
→
Object:
T_cells
(Immune cells)
Original: Flow cytometry#showed#surface expression of CD2/ CD3/ CD7 (dim)/ CD8/ and CD56
#21459
high Confidence
Subject:
excisional_biopsy
(Diagnostic techniques)
→
is_recommended_to_rule_out
→
Object:
invasive_carcinoma
(Invasive carcinoma)
Original: Excisional biopsy#is recommended to rule out#ductal carcinoma in situ and/or invasive carcinoma
#21458
high Confidence
Subject:
excisional_biopsy
(Diagnostic techniques)
→
is_recommended_to_rule_out
→
Object:
ductal_carcinoma_in_situ
(Ductal carcinoma in situ)
Original: Excisional biopsy#is recommended to rule out#ductal carcinoma in situ and/or invasive carcinoma
#21457
high Confidence
Subject:
TRUS-guided_prostate_needle_core_biopsies
(Tissue biopsy sample)
→
were_diagnosed_as
→
Object:
acinar_type_adenocarcinoma
(Acinar adenocarcinoma)
Original: 251 of 863 TRUS-guided prostate needle core biopsies#were diagnosed as#acinar type adenocarcinoma
#21456
high Confidence
Subject:
Foamy_gland_carcinoma
(Tumor type)
→
is_characterized_by
→
Object:
infiltrative_pattern
(Invasive growth)
Original: Foamy gland carcinoma#is characterized by#foamy appearance/ large cytoplasm/ pyknotic nuclei/ inconspicuous nucleoli/ and infiltrative pattern
#21455
high Confidence
Subject:
Foamy_gland_carcinoma
(Tumor type)
→
is_characterized_by
→
Object:
inconspicuous_nucleoli
(Inconspicuous nucleolus)
Original: Foamy gland carcinoma#is characterized by#foamy appearance/ large cytoplasm/ pyknotic nuclei/ inconspicuous nucleoli/ and infiltrative pattern
#21454
high Confidence
Subject:
Foamy_gland_carcinoma
(Tumor type)
→
is_characterized_by
→
Object:
pyknotic_nuclei
(Pyknotic nucleus)
Original: Foamy gland carcinoma#is characterized by#foamy appearance/ large cytoplasm/ pyknotic nuclei/ inconspicuous nucleoli/ and infiltrative pattern
#21453
high Confidence
Subject:
Foamy_gland_carcinoma
(Tumor type)
→
is_characterized_by
→
Object:
large_cytoplasm
(Cytoplasmic characteristics)
Original: Foamy gland carcinoma#is characterized by#foamy appearance/ large cytoplasm/ pyknotic nuclei/ inconspicuous nucleoli/ and infiltrative pattern
#21452
high Confidence
Subject:
Foamy_gland_carcinoma
(Tumor type)
→
is_characterized_by
→
Object:
foamy_appearance
(Foamy appearance)
Original: Foamy gland carcinoma#is characterized by#foamy appearance/ large cytoplasm/ pyknotic nuclei/ inconspicuous nucleoli/ and infiltrative pattern
#21451
high Confidence
Subject:
nuclear_pleomorphism
(Nuclear heterogeneity)
→
is_associated_with
→
Object:
BR_Grade_3_on_histology
(Histology High Level)
Original: marked nuclear pleomorphism#is associated with#BR Grade 3 on histology
#21450
high Confidence
Subject:
histologic_grade
(Histological grading)
→
is_based_on
→
Object:
mitotic_frequency
(Splitting frequency)
Original: histologic grade#is based on#tubule formation/ nuclear pleomorphism/ and mitotic frequency
#21449
high Confidence
Subject:
histologic_grade
(Histological grading)
→
is_based_on
→
Object:
nuclear_pleomorphism
(Nuclear heterogeneity)
Original: histologic grade#is based on#tubule formation/ nuclear pleomorphism/ and mitotic frequency
#21448
high Confidence
Subject:
histologic_grade
(Histological grading)
→
is_based_on
→
Object:
tubule_formation
(Organizational structure characteristics)
Original: histologic grade#is based on#tubule formation/ nuclear pleomorphism/ and mitotic frequency
#21447
high Confidence
Subject:
voided_urine_cytology
(Urine cytology)
→
is_useful_for
→
Object:
follow-up_of_papillary_RCC
(Follow-up)
Original: voided urine cytology#is useful for#screening and follow-up of patients with papillary RCC
#21446
high Confidence
Subject:
voided_urine_cytology
(Urine cytology)
→
is_useful_for
→
Object:
screening_of_papillary_RCC
(Screening)
Original: voided urine cytology#is useful for#screening and follow-up of patients with papillary RCC
#21445
high Confidence
Subject:
histopathological_features
(Histological characteristics)
→
diagnose
→
Object:
pigmented_epithelioid_melanocytoma
(Tumor)
Original: Histopathological features#diagnose#pigmented epithelioid melanocytoma (PEM) in a teratoma of a Carney complex patient
#21444
high Confidence
Subject:
biopsy
(Histological examination)
→
diagnoses
→
Object:
sarcomatoid_carcinoma
(Tumor diseases)
Original: Diagnosis of sarcomatoid carcinoma#can be made by#CT/ MRI/ cytology/ and biopsy
#21443
high Confidence
Subject:
Cytology
(Cytology)
→
diagnoses
→
Object:
sarcomatoid_carcinoma
(Tumor diseases)
Original: Diagnosis of sarcomatoid carcinoma#can be made by#CT/ MRI/ cytology/ and biopsy
#21442
high Confidence
Subject:
MRI
(Imaging Technology)
→
diagnoses
→
Object:
sarcomatoid_carcinoma
(Tumor diseases)
Original: Diagnosis of sarcomatoid carcinoma#can be made by#CT/ MRI/ cytology/ and biopsy
#21441
high Confidence
Subject:
CT
(Imaging Technology)
→
diagnoses
→
Object:
sarcomatoid_carcinoma
(Tumor diseases)
Original: Diagnosis of sarcomatoid carcinoma#can be made by#CT/ MRI/ cytology/ and biopsy
#21440
high Confidence
Subject:
Antigen_receptor_rearrangement
(Gene rearrangement)
→
is_assessed_by
→
Object:
PCR
(Molecular detection technology)
Original: Antigen Receptor Rearrangements (PARR)#are assessed by#PCR
#21439
high Confidence
Subject:
CD30
(Tumor-associated antigens)
→
is_assessed_by
→
Object:
Immunohistochemistry
(Detection Technology)
Original: CD3/ CD20/ and CD30#are assessed by#immunohistochemistry
#21438
high Confidence
Subject:
CD20
(B cell surface molecules)
→
is_assessed_by
→
Object:
Immunohistochemistry
(Detection Technology)
Original: CD3/ CD20/ and CD30#are assessed by#immunohistochemistry
#21437
high Confidence
Subject:
CD3
(T cell surface molecules)
→
is_assessed_by
→
Object:
Immunohistochemistry
(Detection Technology)
Original: CD3/ CD20/ and CD30#are assessed by#immunohistochemistry
#21436
high Confidence
Subject:
rhabdomyoma
(Benign tumors)
→
originates_from
→
Object:
striated_muscle
(Organization Source)
Original: Rhabdomyomas#are#rare benign tumors of striated muscle
#21435
high Confidence
Subject:
AFP
(protein)
→
shows_strong_intracytoplasmic_positivity_in
→
Object:
tumor_cells_with_hepatic_and_bile_duct_epithelium_differentiation
(Cell differentiation characteristics)
Original: Immunohistochemistry for AFP#shows#strong intra cytoplasmic positivity in tumor cells with hepatic and bile duct epithelium differentiation
#21434
high Confidence
Subject:
EBER_transcripts
(Viral RNA)
→
are_present_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: EBER transcripts#are present in#neoplastic cells
#21433
high Confidence
Subject:
Hürthle_cells
(Cell Type)
→
are_found_in
→
Object:
fine_needle_aspirates_of_thyroid_lesions
(Organizational Positioning)
Original: Hürthle cells#are found in#fine needle aspirates of thyroid lesions
#21432
high Confidence
Subject:
Adenomatoid_tumor
(Tumor type)
→
is
→
Object:
benign_neoplasm
(Benign or malignant tumor)
Original: adenomatoid tumor#is#benign neoplasm
#21431
high Confidence
Subject:
fibroepithelial_lesions_of_breast
(Fibroepithelial lesions of the breast)
→
were_classified_into
→
Object:
malignant_phyllodes_tumour
(Malignant phyllodes tumor)
Original: Fibroepithelial lesions of the breast#were classified into#fibroadenoma (FA)/ benign phyllodes tumours (PTLGM)/ borderline (PTBM)/ and malignant (PTHGM)
#21430
high Confidence
Subject:
fibroepithelial_lesions_of_breast
(Fibroepithelial lesions of the breast)
→
were_classified_into
→
Object:
borderline_phyllodes_tumour
(Borderline phyllodes tumor)
Original: Fibroepithelial lesions of the breast#were classified into#fibroadenoma (FA)/ benign phyllodes tumours (PTLGM)/ borderline (PTBM)/ and malignant (PTHGM)
#21429
high Confidence
Subject:
fibroepithelial_lesions_of_breast
(Fibroepithelial lesions of the breast)
→
were_classified_into
→
Object:
benign_phyllodes_tumour
(Benign phyllodes tumor)
Original: Fibroepithelial lesions of the breast#were classified into#fibroadenoma (FA)/ benign phyllodes tumours (PTLGM)/ borderline (PTBM)/ and malignant (PTHGM)
#21428
high Confidence
Subject:
fibroepithelial_lesions_of_breast
(Fibroepithelial lesions of the breast)
→
were_classified_into
→
Object:
fibroadenoma
(Breast fibroadenoma)
Original: Fibroepithelial lesions of the breast#were classified into#fibroadenoma (FA)/ benign phyllodes tumours (PTLGM)/ borderline (PTBM)/ and malignant (PTHGM)
#21427
high Confidence
Subject:
Bortezomib
(Proteasome inhibitors)
→
interferes_with
→
Object:
protein_biosynthesis_at_nucleolar_ribosome_biogenesis_stage
(Molecular Process)
Original: bortezomib#interferes with#protein biosynthesis at nucleolar ribosome biogenesis stage
#21426
high Confidence
Subject:
NRG1
(Ligand protein)
→
activates
→
Object:
ERBB_receptor_tyrosine_kinases
(Receptor tyrosine kinases)
Original: Neuregulin 1 (NRG1)#activates#ErbB receptor tyrosine kinases
#21425
high Confidence
Subject:
EGFR
(Receptor tyrosine kinases)
→
is_overexpressed_in
→
Object:
FLC_tumors
(Tumor tissue)
Original: EFGR overexpression#is evident in#FLC tumors
#21424
high Confidence
Subject:
mTOR_pathway
(signaling pathway)
→
plays_critical_role_in
→
Object:
FLC
(Tumor type)
Original: mTOR pathway activation#plays#a critical role in 47% of FLC tumors
#21423
high Confidence
Subject:
ribosomal_protein_genes_haploinsufficiency
(Gene dosage abnormalities)
→
is_implicated_in
→
Object:
5q-syndrome
(Genetic disorders)
Original: Haploinsufficiency of ribosomal protein genes#is implicated in#Diamond-Blackfan anemia and 5q-syndrome
#21422
high Confidence
Subject:
ribosomal_protein_genes_haploinsufficiency
(Gene dosage abnormalities)
→
is_implicated_in
→
Object:
Diamond-Blackfan_anemia
(Genetic disorders)
Original: Haploinsufficiency of ribosomal protein genes#is implicated in#Diamond-Blackfan anemia and 5q-syndrome
#21421
high Confidence
Subject:
GRK5
(G protein-coupled receptor kinase)
→
is_localized_within
→
Object:
nucleus
(Cellular substructure)
Original: GRK5#is localized within#the nucleus and moderates DNA transcription
#21420
high Confidence
Subject:
RS-OXA_conjugate
(Small molecule drug conjugates)
→
localizes_to
→
Object:
cell_nucleoli
(Cellular substructure)
Original: RS-OXA conjugate#localizes to#cell nucleoli of HCC/ NSCLC/ breast/ colon and cervical cancer cells
#21419
high Confidence
Subject:
Peptide_RS
(Peptides)
→
enables
→
Object:
delineation_from_noncancerous_tissues
(Tissue typing)
Original: Peptide RS#enables#improved HCC micrometastasis discrimination and delineation from noncancerous tissues
#21418
high Confidence
Subject:
Peptide_RS
(Peptides)
→
enables
→
Object:
HCC_micrometastasis_discrimination
(Disease phenotype)
Original: Peptide RS#enables#improved HCC micrometastasis discrimination and delineation from noncancerous tissues
#21417
high Confidence
Subject:
Androgen
(hormone)
→
activates
→
Object:
androgen_receptor
(Receptor protein)
Original: Androgen and androgen receptor (AR) pathways#have been associated with#prostate growth
#21416
high Confidence
Subject:
p19(ARF)
(Tumor suppressor proteins)
→
activates
→
Object:
p53
(Transcription Factors)
Original: p19(ARF)#activates#p53 without affecting Mdm2 localization
#21415
high Confidence
Subject:
Hippo_pathway
(signaling pathway)
→
restricts
→
Object:
YAP_nuclear_entry
(Transcription factor localization)
Original: activation of Hippo pathway#restricts#YAP nuclear entry via phosphorylation by Lats kinases
#21414
high Confidence
Subject:
WDR75
(Ribosomal histones)
→
is
→
Object:
nucleolar_protein
(Nucleolar proteins)
Original: endogenous human WDR75#is#a nucleolar protein
#21413
high Confidence
Subject:
ribosomal_proteins_L11
(Ribosomal proteins)
→
binds_to
→
Object:
MDM2
(Ubiquitin ligase)
Original: elevated levels of p53 after TIF-IA depletion#are due to#increased binding of ribosomal proteins (e.g./ L11) to MDM2 and decreased interaction of MDM2 with p53 and p19(ARF)
#21412
high Confidence
Subject:
Tumor_cells
(Cell Type)
→
express
→
Object:
neuron-specific_enolase
(Enzymes)
Original: Tumor cells#were positive for#HMB-45 and neuron-specific enolase but negative for epithelial markers/ smooth muscle markers/ other neuroendocrine markers/ vimentin/ melan-A/ S-100 protein
#21411
high Confidence
Subject:
Tumor_cells
(Cell Type)
→
express
→
Object:
HMB-45
(Protein markers)
Original: Tumor cells#were positive for#HMB-45 and neuron-specific enolase but negative for epithelial markers/ smooth muscle markers/ other neuroendocrine markers/ vimentin/ melan-A/ S-100 protein
#21410
high Confidence
Subject:
Leishman_stained_smear
(Stained smear)
→
verifies
→
Object:
ductal_hyperplasia
(disease)
Original: Cases#are verified with#Leishman stained smears obtained by FNAB from patients with PDAC or ductal hyperplasia
#21409
high Confidence
Subject:
Leishman_stained_smear
(Stained smear)
→
verifies
→
Object:
PDAC
(disease)
Original: Cases#are verified with#Leishman stained smears obtained by FNAB from patients with PDAC or ductal hyperplasia
#21408
high Confidence
Subject:
granular_cell_tumors
(Tumor)
→
classified_as
→
Object:
non_benign
(Disease phenotype)
Original: spindling of tumor cells/ necrosis/ diffuse pleomorphism/ prominent nucleoli/ high nuclear-cytoplasmic ratio/ and mitotic rate >2 per 10 high-power fields#classify#GCTs as non-benign
#21407
high Confidence
Subject:
Tubulocystic_carcinoma_of_the_kidney
(Tumor subtype)
→
is_recognized_as
→
Object:
distinct_subtype_of_RCC
(Tumor subtype)
Original: Tubulocystic carcinoma of the kidney#is recognized as#a distinct subtype of RCC
#21406
high Confidence
Subject:
AI_solution
(AI Algorithms)
→
achieved
→
Object:
human_expert_performance
(Human expert level)
Original: Solution#achieved#performance similar to human experts in analyzing nuclei and AgNORs
#21405
high Confidence
Subject:
Ki-67
(Proliferation markers)
→
shows_high_proliferation_index_in
→
Object:
triple-negative_breast_cancer
(Tumor tissue)
Original: TMCs#are triple-negative and express#HLA-DR and p53 with high proliferation index
#21404
high Confidence
Subject:
TP53
(Transcription Factors)
→
is_expressed_in
→
Object:
triple-negative_breast_cancer
(Tumor tissue)
Original: TMCs#are triple-negative and express#HLA-DR and p53 with high proliferation index
#21403
high Confidence
Subject:
HLA-DR
(Receptor protein)
→
is_expressed_in
→
Object:
triple-negative_breast_cancer
(Tumor tissue)
Original: TMCs#are triple-negative and express#HLA-DR and p53 with high proliferation index
#21402
high Confidence
Subject:
Ki-67
(Proliferation markers)
→
shows_high_proliferation_index_in
→
Object:
tumor
(Tumor tissue)
Original: Tumors#were diffusely positive for#p53 and showed high Ki-67 proliferation index
#21401
high Confidence
Subject:
HLA-DR
(Receptor protein)
→
shows_positivity_in
→
Object:
mammary_carcinoma
(Tumor tissue)
Original: 111 cases of mammary carcinomas#met criteria for#TMC and showed HLA-DR positivity
#21400
high Confidence
Subject:
Helicobacter_pylori_infection
(Infectious Agents)
→
affects
→
Object:
carcinoma
(Tumor)
Original: Helicobacter pylori infection#affects#gastric epithelia/ gastritis/ intestinal metaplasia/ and carcinoma
#21399
high Confidence
Subject:
Helicobacter_pylori_infection
(Infectious Agents)
→
affects
→
Object:
intestinal_metaplasia
(Pathological changes)
Original: Helicobacter pylori infection#affects#gastric epithelia/ gastritis/ intestinal metaplasia/ and carcinoma
#21398
high Confidence
Subject:
Helicobacter_pylori_infection
(Infectious Agents)
→
affects
→
Object:
gastritis
(disease)
Original: Helicobacter pylori infection#affects#gastric epithelia/ gastritis/ intestinal metaplasia/ and carcinoma
#21397
high Confidence
Subject:
Helicobacter_pylori_infection
(Infectious Agents)
→
affects
→
Object:
gastric_epithelia
(Organization Type)
Original: Helicobacter pylori infection#affects#gastric epithelia/ gastritis/ intestinal metaplasia/ and carcinoma
#21396
high Confidence
Subject:
TP53_protein_expression
(p53 protein expression)
→
is_promising_marker_for
→
Object:
poor_prognosis
(Poor prognosis)
Original: p53-protein expression#appears as#a promising marker of poor prognosis
#21395
high Confidence
Subject:
Nucleolar_organizer_regions
(Nuclear structure region)
→
transcribes
→
Object:
ribosomal_RNA
(rRNA)
Original: Nucleolar organizer regions#transcribe#ribosomal RNA
#21394
high Confidence
Subject:
Nucleolar_organizer_regions
(Nucleolar organizing region)
→
are_loops_of
→
Object:
ribosomal_RNA
(Ribosomal RNA)
Original: Nucleolar organizer regions (NORs)#are loops of#ribosomal RNA in nucleoli
#21393
high Confidence
Subject:
pathologic_staging
(Pathological staging)
→
is_important_for
→
Object:
determining_clinical_outcomes
(Clinical Outcomes)
Original: Clinical and pathologic staging of mediastinal seminomas#are important for#determining clinical outcomes
#21392
high Confidence
Subject:
clinical_staging
(Clinical staging)
→
is_important_for
→
Object:
determining_clinical_outcomes
(Clinical Outcomes)
Original: Clinical and pathologic staging of mediastinal seminomas#are important for#determining clinical outcomes
#21391
high Confidence
Subject:
silver_nitrate_stain
(Dyeing technology)
→
displays
→
Object:
nucleolar_organizer_regions
(Nucleolar region)
Original: Silver nitrate stain#displays#nucleolar organizer regions in formalin-fixed tissue
#21390
high Confidence
Subject:
carcinoma_AgNOR_area
(Cell morphology index)
→
is_larger_than
→
Object:
adenoma_AgNOR_area
(Cell morphology index)
Original: Cross-sectional area of carcinoma AgNORs#was significantly larger than#that of adenoma
#21389
high Confidence
Subject:
Childhood_neuroblastoma_cases
(Disease Cases)
→
were_classified_according to
→
Object:
Shimada_subtyping
(Molecular typing standards)
Original: Childhood neuroblastoma cases#were reviewed and classified according to#Shimada subtyping
#21388
high Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar organizer region)
→
can_be_recognized_with
→
Object:
argyrophilic_stain
(Dyeing technology)
Original: Nucleolar organizer regions#can be recognized with#an argyrophilic stain
#21387
high Confidence
Subject:
AgNOR_distribution
(Molecular pathology indicators)
→
is_used_for
→
Object:
tumor_prognosis
(Tumor prognosis)
Original: AgNOR distribution#is used for#diagnostic and prognostic purposes of tumors
#21386
high Confidence
Subject:
AgNOR_distribution
(Molecular pathology indicators)
→
is_used_for
→
Object:
tumor_diagnosis
(Tumor Diagnosis)
Original: AgNOR distribution#is used for#diagnostic and prognostic purposes of tumors
#21385
high Confidence
Subject:
argyrophilic_nucleolar_organizer_region_staining
(Silver staining of nucleolar organizer region)
→
correlates_with
→
Object:
brain_tumor_grading
(Brain tumor grading)
Original: argyrophilic nucleolar organizer region staining#correlates with#brain tumor classification and grading
#21384
high Confidence
Subject:
argyrophilic_nucleolar_organizer_region_staining
(Silver staining of nucleolar organizer region)
→
correlates_with
→
Object:
brain_tumor_classification
(Brain tumor classification)
Original: argyrophilic nucleolar organizer region staining#correlates with#brain tumor classification and grading
#21383
high Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar organizer region)
→
acts_as
→
Object:
diagnostic_marker
(Diagnostic markers)
Original: Nucleolar organizer regions#act as#a prognostic indicator for stage I non-small cell lung cancer
#21382
high Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar organizer region)
→
acts_as
→
Object:
prognostic_indicator
(Prognostic indicators)
Original: Nucleolar organizer regions#act as#a prognostic indicator for stage I non-small cell lung cancer
#21381
high Confidence
Subject:
Nucleolar_organizer_regions
(DNA domain)
→
are
→
Object:
loops_of_DNA
(DNA Structure)
Original: Nucleolar organizer regions (NORs)#are#loops of DNA
#21380
high Confidence
Subject:
AgNOR_expression
(Silver-stained nucleolar region expression)
→
has
→
Object:
prognostic_role
(Prognostic role)
Original: AgNOR expression#has#a significant prognostic role
#21379
high Confidence
Subject:
CD105_MVD
(Angiogenesis markers)
→
is_positively_correlated_with
→
Object:
VEGF
(Growth Factors)
Original: Positive relevance#was found between#CD105-MVD/ VEGF/ and p53
#21378
high Confidence
Subject:
CD105
(Membrane Protein)
→
is_upregulated_in
→
Object:
tumor_tissue
(Tumor tissue)
Original: Endoglin (CD105) expression#was higher in#tumor tissue compared to normal mucosa
#21377
high Confidence
Subject:
Neuroendocrine tumors
(Tumor type)
→
showed
→
Object:
Ki-67_index_80%
(Proliferation markers)
Original: Neuroendocrine tumors#showed#cells arranged in cords or nests with Ki-67 index of 5% (G2 neuroendocrine tumor) and 80% (small-cell neuroendocrine carcinoma)
#21376
high Confidence
Subject:
AgNOR_count
(Molecular markers)
→
is_used_as
→
Object:
index_of_malignancy_grade
(Tumor grade)
Original: AgNOR count#was used as#an index of malignancy grade
#21375
high Confidence
Subject:
extra_capsular_spread
(Tumor microenvironment characteristics)
→
is
→
Object:
prognostic_factor_in_HNSCC
(Clinical Outcomes)
Original: Extra Capsular Spread (ECS)#is a#prognostic factor in HNSCC
#21374
high Confidence
Subject:
nucleolus_organizer_regions
(Molecular markers)
→
is_used_to_predict
→
Object:
survival
(Clinical Outcomes)
Original: Nucleolar organizer regions (AgNOR)#were studied to#predict survival in limited squamous cell carcinoma of the lung
#21373
high Confidence
Subject:
Proliferative_activity
(Cellular Processes)
→
is_evaluated_by
→
Object:
AgNOR_count
(Molecular markers)
Original: Proliferative activity#is evaluated by#Ki-67 immunohistochemistry and AgNOR count
#21372
high Confidence
Subject:
Proliferative_activity
(Cellular Processes)
→
is_evaluated_by
→
Object:
Ki-67_immunohistochemistry
(Immunohistochemistry)
Original: Proliferative activity#is evaluated by#Ki-67 immunohistochemistry and AgNOR count
#21371
high Confidence
Subject:
Patients_undergoing_surgery_for_colorectal_cancer
(Patient characteristics)
→
are_studied_for
→
Object:
5-year_survival
(Clinical Outcomes)
Original: Patients undergoing surgery for colorectal cancer#are studied for#5-year survival
#21370
high Confidence
Subject:
Intratubular_embryonal_carcinoma
(Histopathological entities)
→
is_variety_of
→
Object:
germ_cell_tumor
(Histopathological entities)
Original: Intratubular embryonal carcinoma#is referred to as#a variety of germ cell tumors
#21369
high Confidence
Subject:
IGCN
(Histopathological entities)
→
is_precursor_of
→
Object:
testicular_cancer
(disease)
Original: Intratubular germ cell neoplasia (IGCN)#is considered to be#a precursor of testicular cancer
#21368
high Confidence
Subject:
Histological_assessment_of_nucleolar_morphology
(Histological evaluation)
→
provides
→
Object:
prognostic_information
(Prognostic information)
Original: Histological assessment of nucleolar morphology#provides#reliable prognostic information
#21367
high Confidence
Subject:
next-generation_sequencing
(Molecular detection technology)
→
is_recommended_to_identify
→
Object:
MAPK/ERK_pathway_mutations_for_targeted_therapy
(Molecular diagnostic markers)
Original: Next-generation sequencing#is recommended to identify#MAPK/ERK pathway mutations for targeted therapy
#21366
high Confidence
Subject:
Immunohistochemical analysis
(Detection Methods)
→
revealed_positivity_for
→
Object:
myogenin
(Transcription Factors)
Original: immunohistochemical analysis#revealed positivity for#desmin/ MyoD1/ and myogenin
#21365
high Confidence
Subject:
Immunohistochemical analysis
(Detection Methods)
→
revealed_positivity_for
→
Object:
MyoD1
(Transcription Factors)
Original: immunohistochemical analysis#revealed positivity for#desmin/ MyoD1/ and myogenin
#21364
high Confidence
Subject:
Immunohistochemical analysis
(Detection Methods)
→
revealed_positivity_for
→
Object:
desmin
(protein)
Original: immunohistochemical analysis#revealed positivity for#desmin/ MyoD1/ and myogenin
#21363
high Confidence
Subject:
rhabdomyosarcoma
(Tumor type)
→
shows
→
Object:
skeletal_muscle_differentiation
(Cell differentiation characteristics)
Original: rhabdomyosarcomas#are#malignant tumors with skeletal muscle differentiation
#21362
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
actin
(protein)
Original: Tumor cells#were negative for#CD207/Langerin/ CKpan/ CD21/ HMB45/ ALK/ actin
#21361
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
ALK
(protein)
Original: Tumor cells#were negative for#CD207/Langerin/ CKpan/ CD21/ HMB45/ ALK/ actin
#21360
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
HMB45
(protein)
Original: Tumor cells#were negative for#CD207/Langerin/ CKpan/ CD21/ HMB45/ ALK/ actin
#21359
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
CD21
(protein)
Original: Tumor cells#were negative for#CD207/Langerin/ CKpan/ CD21/ HMB45/ ALK/ actin
#21358
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
CKpan
(protein)
Original: Tumor cells#were negative for#CD207/Langerin/ CKpan/ CD21/ HMB45/ ALK/ actin
#21357
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
CD207
(protein)
Original: Tumor cells#were negative for#CD207/Langerin/ CKpan/ CD21/ HMB45/ ALK/ actin
#21356
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CCND1
(protein)
Original: Tumor cells#were positive for#S-100/ CD1a/ CD68/ cyclin D1
#21355
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD68
(protein)
Original: Tumor cells#were positive for#S-100/ CD1a/ CD68/ cyclin D1
#21354
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD1A
(protein)
Original: Tumor cells#were positive for#S-100/ CD1a/ CD68/ cyclin D1
#21353
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
S100A1
(protein)
Original: Tumor cells#were positive for#S-100/ CD1a/ CD68/ cyclin D1
#21352
high Confidence
Subject:
Pemphigus_vulgaris
(disease)
→
diagnosed_by
→
Object:
immunofluorescence
(Diagnostic Methods)
Original: Pemphigus vulgaris#was diagnosed by#histological examination and immunofluorescence
#21351
high Confidence
Subject:
Pemphigus_vulgaris
(disease)
→
diagnosed_by
→
Object:
histological_examination
(Diagnostic Methods)
Original: Pemphigus vulgaris#was diagnosed by#histological examination and immunofluorescence
#21350
high Confidence
Subject:
Scrape_cytology
(Cytology)
→
suggests
→
Object:
Paget disease of the nipple
(disease)
Original: Scrape cytology#suggested#Paget's disease of the nipple
#21349
high Confidence
Subject:
Pemphigus_vulgaris
(disease)
→
confirmed_by
→
Object:
immunocytochemical_examination
(Diagnostic Methods)
Original: Pemphigus vulgaris#was confirmed by#histological and immunocytochemical examination
#21348
high Confidence
Subject:
Pemphigus_vulgaris
(disease)
→
confirmed_by
→
Object:
histological_examination
(Diagnostic Methods)
Original: Pemphigus vulgaris#was confirmed by#histological and immunocytochemical examination
#21347
high Confidence
Subject:
intestinal_masses
(Disease phenotype)
→
are_associated_with
→
Object:
intestinal_perforation
(Clinical complications)
Original: Intestinal masses#are associated with#intestinal perforation in 62% of cases
#21346
high Confidence
Subject:
high-grade_histological_atypia
(Histological characteristics)
→
increases
→
Object:
risk_of_melanoma
(Disease Risk)
Original: High-grade histological atypia#increases#risk of melanoma
#21345
high Confidence
Subject:
Bone_marrow_trephine_biopsy
(Pathological examination)
→
showed
→
Object:
acute_myelomonocytic_leukemia
(Hematologic malignancies)
Original: Bone marrow trephine biopsy#showed#acute myelomonocytic leukemia
#21344
high Confidence
Subject:
Adamantinoma-like_Ewing_sarcoma
(Tumor diseases)
→
is_characterized_as
→
Object:
Ewing_sarcoma
(Tumor diseases)
Original: Neoplasm#is characterized as#adamantinoma-like Ewing sarcoma
#21343
high Confidence
Subject:
WHO
(World Health Organization)
→
reclassified
→
Object:
oncocytic_subtype_of_intraductal_papillary_mucinous_neoplasm
(Tumor subtype)
Original: WHO#reclassified#intraductal oncocytic papillary neoplasm as the 'oncocytic subtype' of intraductal papillary mucinous neoplasm in 2010
#21342
high Confidence
Subject:
WHO
(World Health Organization)
→
reclassified
→
Object:
intraductal_oncocytic_papillary_neoplasm
(Tumor type)
Original: WHO#reclassified#intraductal oncocytic papillary neoplasm as the 'oncocytic subtype' of intraductal papillary mucinous neoplasm in 2010
#21341
high Confidence
Subject:
Transbronchial_lung_biopsy
(Diagnostic techniques)
→
is_effective_method_for
→
Object:
diagnosis_of_Pulmonary_intravascular_large_B_cell_lymphoma
(Disease diagnosis)
Original: Transbronchial lung biopsy#is#an effective method to confirm the diagnosis
#21340
high Confidence
Subject:
chemotherapy
(Chemotherapy regimen)
→
achieved
→
Object:
complete_remission
(Response to treatment)
Original: Six cases#achieved#complete remission after chemotherapy
#21339
high Confidence
Subject:
R-CHOP
(Chemotherapy regimen)
→
was_administered_to
→
Object:
patients_with_Pulmonary_intravascular_large_B_cell_lymphoma
(patient)
Original: Seven patients#received#R-CHOP-based chemotherapy
#21338
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
express
→
Object:
CD79A
(Surface antigen)
Original: Tumor cells#expressed#mature B cell-associated antigens CD20 and CD79a
#21337
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
express
→
Object:
CD20
(Surface antigen)
Original: Tumor cells#expressed#mature B cell-associated antigens CD20 and CD79a
#21336
high Confidence
Subject:
atypical_adenomatous_hyperplasia
(Benign lesions)
→
is_distinguished_from
→
Object:
well-differentiated_prostatic_adenocarcinoma
(Tumor type)
Original: Diagnosis of atypical adenomatous hyperplasia (AAH)#is distinguished from#well-differentiated prostatic adenocarcinoma with small acinar pattern (PACsmac)
#21335
high Confidence
Subject:
percutaneous_fine-needle_aspiration_biopsy
(Clinical operation)
→
performed_on
→
Object:
liver
(organ)
Original: 1673 patients#underwent#percutaneous fine-needle aspiration biopsy of the liver
#21334
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
were_strongly_positive_for
→
Object:
FSCN1
(Actin-binding protein)
Original: Tumor cells#were strongly positive for#vimentin/ CD68/ S-100 protein/ CD45/leukocyte common antigen/ and fascin
#21333
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
were_strongly_positive_for
→
Object:
PTPRC
(common leukocyte antigen)
Original: Tumor cells#were strongly positive for#vimentin/ CD68/ S-100 protein/ CD45/leukocyte common antigen/ and fascin
#21332
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
were_strongly_positive_for
→
Object:
S100B
(Calcium Binding Protein)
Original: Tumor cells#were strongly positive for#vimentin/ CD68/ S-100 protein/ CD45/leukocyte common antigen/ and fascin
#21331
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
were_strongly_positive_for
→
Object:
CD68
(Macrophage markers)
Original: Tumor cells#were strongly positive for#vimentin/ CD68/ S-100 protein/ CD45/leukocyte common antigen/ and fascin
#21330
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
were_strongly_positive_for
→
Object:
VIM
(Cytoskeletal proteins)
Original: Tumor cells#were strongly positive for#vimentin/ CD68/ S-100 protein/ CD45/leukocyte common antigen/ and fascin
#21329
high Confidence
Subject:
Mucoepidermoid_carcinoma_of_submandibular_gland
(Tumor type)
→
is_observed_in
→
Object:
pleural_fluid
(Body fluid specimens)
Original: Mucoepidermoid carcinoma of submandibular gland origin#is observed in#pleural fluid
#21328
high Confidence
Subject:
Small-cell_variant_of_RO
(Tumor subtype)
→
is_considered
→
Object:
benign_renal_neoplasm
(Benign renal tumor)
Original: Small-cell variant of RO#is considered#benign renal neoplasms with good prognosis
#21327
high Confidence
Subject:
correct_diagnosis
(Diagnosis conclusion)
→
was_made_by
→
Object:
open_biopsy_revealing_necrosis_due_to_infarction_of_intraductal_papilloma
(Histological evidence)
Original: Correct diagnosis#was made by#open biopsy revealing necrosis due to infarction of intraductal papilloma
#21326
high Confidence
Subject:
cellular_features
(Cell characteristics)
→
are_considered_as
→
Object:
evidence_of_ductal_carcinoma_of_the_breast
(Breast ductal carcinoma evidence)
Original: Cellular features#were considered as#evidence of ductal carcinoma of the breast
#21325
high Confidence
Subject:
excisional_biopsy
(Biopsy)
→
revealed
→
Object:
infiltration_with_diffuse_B-cell_leukemia_lymphoma
(Pathological manifestations)
Original: Excisional biopsy#revealed#infiltration with diffuse B-cell leukemia/lymphoma
#21324
high Confidence
Subject:
positron_emission_tomography_computed_tomography
(Imaging tests)
→
detected
→
Object:
increased_metabolic_activity_in_spleen
(Imaging findings)
Original: Positron emission tomography-computed tomography#detected#increased metabolic activity in multiple lymph nodes/ bone marrow/ and extremely enlarged spleen
#21323
high Confidence
Subject:
positron_emission_tomography_computed_tomography
(Imaging tests)
→
detected
→
Object:
increased_metabolic_activity_in_bone_marrow
(Imaging findings)
Original: Positron emission tomography-computed tomography#detected#increased metabolic activity in multiple lymph nodes/ bone marrow/ and extremely enlarged spleen
#21322
high Confidence
Subject:
positron_emission_tomography_computed_tomography
(Imaging tests)
→
detected
→
Object:
increased_metabolic_activity_in_lymph_nodes
(Imaging findings)
Original: Positron emission tomography-computed tomography#detected#increased metabolic activity in multiple lymph nodes/ bone marrow/ and extremely enlarged spleen
#21321
high Confidence
Subject:
positron_emission_tomography_with_FDG
(Imaging tests)
→
revealed
→
Object:
systemic_metastasis
(Disease phenotype)
Original: Computed tomography and positron emission tomography with fluorodeoxyglucose#revealed#systemic metastasis
#21320
high Confidence
Subject:
computed_tomography
(Imaging tests)
→
revealed
→
Object:
systemic_metastasis
(Disease phenotype)
Original: Computed tomography and positron emission tomography with fluorodeoxyglucose#revealed#systemic metastasis
#21319
high Confidence
Subject:
original_cytological_diagnosis
(Pathological diagnosis)
→
was
→
Object:
adenosquamous_carcinoma
(Tumor diseases)
Original: Original cytological diagnosis#was#adeno-squamous carcinoma
#21318
high Confidence
Subject:
FUS::TFCP2_fusion_transcript
(Fusion gene)
→
confirms
→
Object:
RMS_diagnosis
(Diagnosis conclusion)
Original: Molecular studies#revealed#a FUS::TFCP2 fusion transcript confirming RMS diagnosis
#21317
high Confidence
Subject:
cellular_EMC
(Tumor type)
→
exhibits
→
Object:
KIT_exon_13_mutation
(Gene mutation)
Original: cellular EMC#exhibits#EWSR1-NR4A3 fusion and KIT exon 13 mutations
#21316
high Confidence
Subject:
cellular_EMC
(Tumor type)
→
exhibits
→
Object:
EWSR1-NR4A3_fusion
(Gene fusion)
Original: cellular EMC#exhibits#EWSR1-NR4A3 fusion and KIT exon 13 mutations
#21315
high Confidence
Subject:
Primary neuroendocrine carcinoma of the vagina
(Tumor type)
→
is
→
Object:
rare entity
(Rare disease attributes)
Original: Primary neuroendocrine carcinoma of the vagina#is#a rare entity
#21314
high Confidence
Subject:
EWS-ATF1_fusion_transcript
(Gene fusion)
→
is_representative_of
→
Object:
t(12;22)_reciprocal_translocation
(Chromosomal translocation)
Original: EWS-ATF1 fusion transcripts#are representative of#t(12;22) clear cell sarcoma reciprocal translocation
#21313
high Confidence
Subject:
postoperative_radiation
(Radiation therapy)
→
resulted_in
→
Object:
disease-free_status_for_6_years
(Clinical Outcomes)
Original: Postoperative radiation#was given as#50 Gy/ resulting in disease-free status for 6 years
#21312
high Confidence
Subject:
cells
(cell)
→
were_infected_with
→
Object:
Epstein-Barr_virus
(Virus)
Original: In situ hybridization#showed#cells were infected with Epstein-Barr (EB) virus
#21311
high Confidence
Subject:
polypoid_tumor_of_cervical_trachea
(Tumor)
→
was_recognized_by
→
Object:
fiberoptic_bronchoscopy
(Endoscopic techniques)
Original: Polypoid tumor of the cervical trachea#was recognized by#neck X-ray/ CT scan/ and fiberoptic bronchoscopy
#21310
high Confidence
Subject:
polypoid_tumor_of_cervical_trachea
(Tumor)
→
was_recognized_by
→
Object:
CT_scan
(Imaging Technology)
Original: Polypoid tumor of the cervical trachea#was recognized by#neck X-ray/ CT scan/ and fiberoptic bronchoscopy
#21309
high Confidence
Subject:
polypoid_tumor_of_cervical_trachea
(Tumor)
→
was_recognized_by
→
Object:
neck_X-ray
(Imaging Technology)
Original: Polypoid tumor of the cervical trachea#was recognized by#neck X-ray/ CT scan/ and fiberoptic bronchoscopy
#21308
high Confidence
Subject:
LELCs
(Tumor)
→
are_designated_as
→
Object:
tumors_arising_outside_nasopharynx
(Tumor type)
Original: Lymphoepithelioma-like carcinomas (LELCs)#are designated as#tumors arising outside the nasopharynx
#21307
high Confidence
Subject:
FNAC
(Detection Technology)
→
allows
→
Object:
diagnosis_of_specific_renal_tumors_in_infancy
(Disease diagnosis)
Original: FNAC#allows#diagnosis of specific renal tumors in infancy
#21306
high Confidence
Subject:
parachordoma
(Tumor)
→
is
→
Object:
benign_tumor
(Tumor nature)
Original: parachordoma#is#a benign tumor with cytological features of malignancy
#21305
high Confidence
Subject:
extrarenal_malignant_rhabdoid_tumors
(Tumor type)
→
were_confirmed_by
→
Object:
electron_microscopic_examination
(Ultrastructural examination)
Original: extrarenal malignant rhabdoid tumors#were confirmed by#histologic and electron microscopic examination
#21304
high Confidence
Subject:
extrarenal_malignant_rhabdoid_tumors
(Tumor type)
→
were_confirmed_by
→
Object:
histologic_examination
(Pathology testing)
Original: extrarenal malignant rhabdoid tumors#were confirmed by#histologic and electron microscopic examination
#21303
high Confidence
Subject:
rhabdoid_feature
(Histological characteristics)
→
is_required_by
→
Object:
International_Collaboration_on_Cancer_Reporting
(Clinical Standards Organization)
Original: Reporting of sarcomatoid and rhabdoid features in RCC#is required by#College of American Pathologists and International Collaboration on Cancer Reporting
#21302
high Confidence
Subject:
sarcomatoid_feature
(Histological characteristics)
→
is_required_by
→
Object:
International_Collaboration_on_Cancer_Reporting
(Clinical Standards Organization)
Original: Reporting of sarcomatoid and rhabdoid features in RCC#is required by#College of American Pathologists and International Collaboration on Cancer Reporting
#21301
high Confidence
Subject:
rhabdoid_feature
(Histological characteristics)
→
is_required_by
→
Object:
CAP
(Clinical Standards Organization)
Original: Reporting of sarcomatoid and rhabdoid features in RCC#is required by#College of American Pathologists and International Collaboration on Cancer Reporting
#21300
high Confidence
Subject:
sarcomatoid_feature
(Histological characteristics)
→
is_required_by
→
Object:
CAP
(Clinical Standards Organization)
Original: Reporting of sarcomatoid and rhabdoid features in RCC#is required by#College of American Pathologists and International Collaboration on Cancer Reporting
#21299
high Confidence
Subject:
renal_cell_carcinoma
(disease)
→
shows
→
Object:
distinctive_molecular_features
(Molecular characteristics)
Original: Studies#have shown#RCCs with sarcomatoid and rhabdoid differentiation have distinctive molecular features
#21298
high Confidence
Subject:
neuroendocrine_markers
(Molecular markers)
→
are_detected_in
→
Object:
gastric_signet-ring_cell_carcinoma
(Tumor type)
Original: The patient#was diagnosed with#mucin-negative gastric signet-ring cell carcinoma with neuroendocrine markers
#21297
high Confidence
Subject:
HLRCC_associated_renal_cell_carcinomas
(Tumor type)
→
associated_with
→
Object:
poor_clinical_outcomes
(Clinical Outcomes)
Original: HLRCC-associated renal cell carcinomas#are#high stage at presentation
#21296
high Confidence
Subject:
HLRCC_associated_renal_cell_carcinomas
(Tumor type)
→
associated_with
→
Object:
aggressive_behavior
(Disease phenotype)
Original: HLRCC-associated renal cell carcinomas#are#high stage at presentation
#21295
high Confidence
Subject:
Extended_thymectomy
(Treatment)
→
should_be_performed_for
→
Object:
thymoma
(Tumor type)
Original: Extended thymectomy#should be performed for#thymoma to prevent recurrence
#21294
high Confidence
Subject:
Thymoma
(Tumor type)
→
measured
→
Object:
70x30x30 mm
(Disease phenotype characteristics)
Original: Thymoma#measured#70 x 30 x 30 mm
#21293
high Confidence
Subject:
Tumors
(Tumor type)
→
characterized_by
→
Object:
eosinophilic_granular_cytoplasm
(Histological characteristics)
Original: Tumors#characterized by#intracytoplasmic and intraluminal vacuoles/ eosinophilic granular cytoplasm
#21292
high Confidence
Subject:
Tumors
(Tumor type)
→
characterized_by
→
Object:
intraluminal_vacuoles
(Histological characteristics)
Original: Tumors#characterized by#intracytoplasmic and intraluminal vacuoles/ eosinophilic granular cytoplasm
#21291
high Confidence
Subject:
Tumors
(Tumor type)
→
characterized_by
→
Object:
intracytoplasmic_vacuoles
(Histological characteristics)
Original: Tumors#characterized by#intracytoplasmic and intraluminal vacuoles/ eosinophilic granular cytoplasm
#21290
high Confidence
Subject:
Tumor
(Tumor type)
→
measured
→
Object:
3_cm_in_diameter
(Disease phenotype characteristics)
Original: Tumor#measured#3 cm in diameter
#21289
high Confidence
Subject:
Primary_angiosarcomas
(Tumor type)
→
are
→
Object:
exceptionally_rare
(Disease phenotype characteristics)
Original: Primary angiosarcomas#are#exceptionally rare vascular tumors
#21288
high Confidence
Subject:
Primary_angiosarcomas
(Tumor type)
→
are
→
Object:
vascular_tumors
(Tumor type)
Original: Primary angiosarcomas#are#exceptionally rare vascular tumors
#21287
high Confidence
Subject:
Primary_pulmonary_Hodgkin's_lymphoma
(Rare tumors)
→
is
→
Object:
extremely_rare
(Rare disease phenotypes)
Original: Primary pulmonary Hodgkin's lymphoma#is#extremely rare
#21286
high Confidence
Subject:
epithelioid_sarcoma
(Tumor type)
→
associated_with
→
Object:
complete_loss_of_SMARCB1_expression
(Abnormal gene expression)
Original: pediatric tumors with complete loss of SMARCB1 expression#include#cribriform neuroepithelial tumor/ renal medullary carcinoma/ and epithelioid sarcoma
#21285
high Confidence
Subject:
renal_medullary_carcinoma
(Tumor type)
→
associated_with
→
Object:
complete_loss_of_SMARCB1_expression
(Abnormal gene expression)
Original: pediatric tumors with complete loss of SMARCB1 expression#include#cribriform neuroepithelial tumor/ renal medullary carcinoma/ and epithelioid sarcoma
#21284
high Confidence
Subject:
cribriform_neuroepithelial_tumor
(Tumor type)
→
associated_with
→
Object:
complete_loss_of_SMARCB1_expression
(Abnormal gene expression)
Original: pediatric tumors with complete loss of SMARCB1 expression#include#cribriform neuroepithelial tumor/ renal medullary carcinoma/ and epithelioid sarcoma
#21283
high Confidence
Subject:
cytological_criteria_for_SCLC
(Diagnostic criteria)
→
include
→
Object:
necrotic_debris
(Cytological characteristics)
Original: cytological criteria for diagnosis of SCLC#include#high cellularity/ small cell size/ scant cytoplasm/ coarsely granulated chromatin/ inconspicuous nucleoli/ Azzopardi crush effect/ and necrotic debris
#21282
high Confidence
Subject:
cytological_criteria_for_SCLC
(Diagnostic criteria)
→
include
→
Object:
Azzopardi_crush_effect
(Cytological characteristics)
Original: cytological criteria for diagnosis of SCLC#include#high cellularity/ small cell size/ scant cytoplasm/ coarsely granulated chromatin/ inconspicuous nucleoli/ Azzopardi crush effect/ and necrotic debris
#21281
high Confidence
Subject:
cytological_criteria_for_SCLC
(Diagnostic criteria)
→
include
→
Object:
inconspicuous_nucleoli
(Cytological characteristics)
Original: cytological criteria for diagnosis of SCLC#include#high cellularity/ small cell size/ scant cytoplasm/ coarsely granulated chromatin/ inconspicuous nucleoli/ Azzopardi crush effect/ and necrotic debris
#21280
high Confidence
Subject:
cytological_criteria_for_SCLC
(Diagnostic criteria)
→
include
→
Object:
coarsely_granulated_chromatin
(Cytological characteristics)
Original: cytological criteria for diagnosis of SCLC#include#high cellularity/ small cell size/ scant cytoplasm/ coarsely granulated chromatin/ inconspicuous nucleoli/ Azzopardi crush effect/ and necrotic debris
#21279
high Confidence
Subject:
cytological_criteria_for_SCLC
(Diagnostic criteria)
→
include
→
Object:
scant_cytoplasm
(Cytological characteristics)
Original: cytological criteria for diagnosis of SCLC#include#high cellularity/ small cell size/ scant cytoplasm/ coarsely granulated chromatin/ inconspicuous nucleoli/ Azzopardi crush effect/ and necrotic debris
#21278
high Confidence
Subject:
cytological_criteria_for_SCLC
(Diagnostic criteria)
→
include
→
Object:
small_cell_size
(Cytological characteristics)
Original: cytological criteria for diagnosis of SCLC#include#high cellularity/ small cell size/ scant cytoplasm/ coarsely granulated chromatin/ inconspicuous nucleoli/ Azzopardi crush effect/ and necrotic debris
#21277
high Confidence
Subject:
cytological_criteria_for_SCLC
(Diagnostic criteria)
→
include
→
Object:
high_cellularity
(Cytological characteristics)
Original: cytological criteria for diagnosis of SCLC#include#high cellularity/ small cell size/ scant cytoplasm/ coarsely granulated chromatin/ inconspicuous nucleoli/ Azzopardi crush effect/ and necrotic debris
#21276
high Confidence
Subject:
small-cell_lung_carcinoma
(Tumor type)
→
belongs_to
→
Object:
neuroendocrine_group_of_lung_tumors
(Tumor classification)
Original: Small-cell lung carcinoma (SCLC)#belongs to#neuroendocrine group of lung tumors
#21275
high Confidence
Subject:
histologic_features
(Histological characteristics)
→
confirmed
→
Object:
pigmented_epithelioid_angiomyolipoma
(Tumor type)
Original: histologic/ histochemical/ and immunohistochemical features#confirmed#three synchronous primary tumors in the same kidney
#21274
high Confidence
Subject:
histologic_features
(Histological characteristics)
→
confirmed
→
Object:
clear_cell_RCC
(Tumor type)
Original: histologic/ histochemical/ and immunohistochemical features#confirmed#three synchronous primary tumors in the same kidney
#21273
high Confidence
Subject:
histologic_features
(Histological characteristics)
→
confirmed
→
Object:
chromophobe_RCC
(Tumor type)
Original: histologic/ histochemical/ and immunohistochemical features#confirmed#three synchronous primary tumors in the same kidney
#21272
high Confidence
Subject:
well-demarcated_tumor
(Tumor tissue)
→
diagnostic_of
→
Object:
seminoma
(Tumor type)
Original: left testis#has#a well-demarcated tumor diagnostic of seminoma
#21271
high Confidence
Subject:
cystic_sebaceous_neoplasms
(Tumor type)
→
are_characterized_as
→
Object:
marker_lesions_of_Muir-Torre_syndrome
(Diagnostic markers)
Original: Cystic sebaceous neoplasms#are characterized as#marker lesions of Muir-Torre syndrome
#21270
high Confidence
Subject:
adenocarcinoma_cells
(Tumor cells)
→
metastasizes_to
→
Object:
liver
(organ)
Original: Cells of adenocarcinomas#metastasized to#the liver
#21269
high Confidence
Subject:
gleason_score
(Tumor grade)
→
varies_to
→
Object:
gleason_score_of_9
(Disease phenotype)
Original: Gleason score#varied from#4 to 9
#21268
high Confidence
Subject:
gleason_score
(Tumor grade)
→
varies_from
→
Object:
gleason_score_of_4
(Disease phenotype)
Original: Gleason score#varied from#4 to 9
#21267
high Confidence
Subject:
bladder_cytology
(Cytology)
→
is_used_to_monitor
→
Object:
early_stage_bladder_cancer
(Disease phenotype)
Original: Bladder cytology#is used to#detect and monitor early stage bladder cancer
#21266
high Confidence
Subject:
bladder_cytology
(Cytology)
→
is_used_to_detect
→
Object:
early_stage_bladder_cancer
(Disease phenotype)
Original: Bladder cytology#is used to#detect and monitor early stage bladder cancer
#21265
high Confidence
Subject:
diagnosis_of_prostate_adenocarcinoma
(diagnosis)
→
is_based_on
→
Object:
supportive_features
(Auxiliary Features)
Original: diagnosis of prostate adenocarcinoma#is based on#multiple diagnostic criteria and supportive features
#21264
high Confidence
Subject:
diagnosis_of_prostate_adenocarcinoma
(diagnosis)
→
is_based_on
→
Object:
diagnostic_criteria
(Diagnostic criteria)
Original: diagnosis of prostate adenocarcinoma#is based on#multiple diagnostic criteria and supportive features
#21263
high Confidence
Subject:
pathological_intraluminal_secretions
(Pathological cavity secretions)
→
are_suspicious_for
→
Object:
prostate_cancer
(cancer)
Original: pathological intraluminal secretions#are suspicious for#prostate cancer
#21262
high Confidence
Subject:
histological_diagnosis_of_prostate_cancer
(Histological diagnosis)
→
1. Reliance
→
Object:
cytological_findings
(Cytological characteristics)
Original: histological diagnosis of prostate cancer#relies on#structural and cytological findings
#21261
high Confidence
Subject:
histological_diagnosis_of_prostate_cancer
(Histological diagnosis)
→
1. Reliance
→
Object:
structural_findings
(Structural features)
Original: histological diagnosis of prostate cancer#relies on#structural and cytological findings
#21260
high Confidence
Subject:
lymphoid_cells
(Immune cells)
→
are_positive_for
→
Object:
TIA-1
(Immune markers)
Original: Lymphoid cells#are positive for#CD3/ CD8/ granzymeB/ TIA-1
#21259
high Confidence
Subject:
lymphoid_cells
(Immune cells)
→
are_positive_for
→
Object:
granzymeB
(Immune markers)
Original: Lymphoid cells#are positive for#CD3/ CD8/ granzymeB/ TIA-1
#21258
high Confidence
Subject:
lymphoid_cells
(Immune cells)
→
are_positive_for
→
Object:
CD8
(Immune markers)
Original: Lymphoid cells#are positive for#CD3/ CD8/ granzymeB/ TIA-1
#21257
high Confidence
Subject:
lymphoid_cells
(Immune cells)
→
are_positive_for
→
Object:
CD3
(Immune markers)
Original: Lymphoid cells#are positive for#CD3/ CD8/ granzymeB/ TIA-1
#21256
high Confidence
Subject:
VIN_usual_type
(Pathological type)
→
is_related_to
→
Object:
HPV_high_risk_type_infection
(Viral infection)
Original: VIN/ usual type#is related to#HPV high-risk type infection
#21255
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
are_immunoreactive_with
→
Object:
CD10
(Protein molecules)
Original: Neoplastic cells#are immunoreactive with#CD10
#21254
high Confidence
Subject:
SSEA-3
(Glycolipid antigen)
→
is_expressed_in
→
Object:
cells
(Tumor cells)
Original: globoseries glycolipid antigen SSEA-3#is expressed in#cells
#21253
high Confidence
Subject:
Immunohistochemistry
(Diagnostic techniques)
→
is_useful_for
→
Object:
sex_cord-stromal_tumor
(disease)
Original: immunohistochemistry#was useful in#confirming a sex cord-stromal tumor
#21252
high Confidence
Subject:
High-grade_serous_carcinoma
(Tumor diseases)
→
is
→
Object:
most_common_epithelial_carcinoma_of_tubo-ovarian_region
(Disease Definition)
Original: High-grade serous carcinoma (HGSC)#is#the most common epithelial carcinoma of the tubo-ovarian region
#21251
high Confidence
Subject:
Immunoblastic_sarcoma
(Tumor)
→
classified_as
→
Object:
immunoblastic_sarcoma
(Tumor subtype)
Original: Tumors#classified as#"diffuse large lymphoid lymphomas with pyroninophilia" or "immunoblastic sarcomas"
#21250
high Confidence
Subject:
Diffuse_large_lymphoid_lymphoma
(Tumor)
→
classified_as
→
Object:
diffuse_large_lymphoid_lymphoma_with_pyroninophilia
(Tumor subtype)
Original: Tumors#classified as#"diffuse large lymphoid lymphomas with pyroninophilia" or "immunoblastic sarcomas"
#21249
high Confidence
Subject:
cells
(Tumor cells)
→
are_reactive_for
→
Object:
CD31
(protein)
Original: Cells#were reactive for#factor VIII-related antigen and CD31
#21248
high Confidence
Subject:
cells
(Tumor cells)
→
are_reactive_for
→
Object:
factor_VIII-related_antigen
(protein)
Original: Cells#were reactive for#factor VIII-related antigen and CD31
#21247
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
display
→
Object:
granzyme_B_negative_immunophenotype
(Immunophenotype)
Original: Tumor cells#displayed#CD3+/ CD8+/ CD4+/ TIA1+/ granzyme B(-) immunophenotype
#21246
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
display
→
Object:
TIA1_positive_immunophenotype
(Immunophenotype)
Original: Tumor cells#displayed#CD3+/ CD8+/ CD4+/ TIA1+/ granzyme B(-) immunophenotype
#21245
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
display
→
Object:
CD4_positive_immunophenotype
(Immunophenotype)
Original: Tumor cells#displayed#CD3+/ CD8+/ CD4+/ TIA1+/ granzyme B(-) immunophenotype
#21244
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
display
→
Object:
CD8_positive_immunophenotype
(Immunophenotype)
Original: Tumor cells#displayed#CD3+/ CD8+/ CD4+/ TIA1+/ granzyme B(-) immunophenotype
#21243
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
display
→
Object:
CD3_positive_immunophenotype
(Immunophenotype)
Original: Tumor cells#displayed#CD3+/ CD8+/ CD4+/ TIA1+/ granzyme B(-) immunophenotype
#21242
high Confidence
Subject:
signet_ring_cell
(Cell morphology)
→
associated_with
→
Object:
ALK_gene_fusion
(Gene rearrangement)
Original: Cases with signet ring cells#show#a strong association with ALK gene fusions and solid pattern
#21241
high Confidence
Subject:
hepatocellular_carcinoma (HCC)
(disease)
→
is_graded_using
→
Object:
modified_Edmondson_system
(Diagnostic Tools)
Original: Hepatocellular carcinoma (HCC)#is graded using#a modified Edmondson system (ES)
#21240
high Confidence
Subject:
Barrett's Esophagus (BE)
(disease)
→
is_recognized_by
→
Object:
goblet_cells
(Cell Type)
Original: BE#is recognized by#the presence of goblet cells within clusters of uniform columnar cells with vesicular nuclei
#21239
high Confidence
Subject:
adenosquamous_carcinoma
(Tumor type)
→
classified_as
→
Object:
adenosquamous_carcinoma
(Tumor type)
Original: 143 cases#included#endocervical adenocarcinoma/ combined adenocarcinoma-squamous carcinoma/ and adenosquamous carcinoma
#21238
high Confidence
Subject:
combined_adenocarcinoma-squamous_carcinoma
(Tumor type)
→
classified_as
→
Object:
adenosquamous_carcinoma
(Tumor type)
Original: 143 cases#included#endocervical adenocarcinoma/ combined adenocarcinoma-squamous carcinoma/ and adenosquamous carcinoma
#21237
high Confidence
Subject:
endocervical_adenocarcinoma
(Tumor type)
→
classified_as
→
Object:
adenocarcinoma
(Tumor type)
Original: 143 cases#included#endocervical adenocarcinoma/ combined adenocarcinoma-squamous carcinoma/ and adenosquamous carcinoma
#21236
high Confidence
Subject:
squash_cytologic_preparation
(Slice Cytology Preparation)
→
diagnoses
→
Object:
metastatic_HCC_of_brain
(Disease diagnosis)
Original: A case of metastatic HCC of brain#was diagnosed by#squash cytologic preparation
#21235
high Confidence
Subject:
FNA
(Fine needle aspiration)
→
diagnoses
→
Object:
low-grade_lymphoma_of_MALT
(Disease diagnosis)
Original: Low-grade lymphoma of MALT#was diagnosed by#FNA
#21234
high Confidence
Subject:
histology
(Histological examination)
→
confirms
→
Object:
cytologic_diagnosis
(Cytological diagnosis)
Original: Histology and gene rearrangement studies#confirmed#cytologic diagnosis
#21233
high Confidence
Subject:
immunophenotyping_study
(Immunophenotyping)
→
suggests
→
Object:
diagnosis_of_low-grade_B-cell_lymphoma_of_MALT
(Disease diagnosis)
Original: Cytomorphology coupled with immunophenotyping study#suggested#diagnosis of low-grade B-cell lymphoma of MALT
#21232
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
p63
(Transcription Factors)
Original: Tumor cells#are negative for#S100 and p63
#21231
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
S100
(Calcium Binding Protein)
Original: Tumor cells#are negative for#S100 and p63
#21230
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
vimentin
(Interstitial proteins)
Original: Tumor cells#are positive for#cytokeratin (AE1/AE3) and vimentin
#21229
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
cytokeratin_AE1/AE3
(Cytoskeletal proteins)
Original: Tumor cells#are positive for#cytokeratin (AE1/AE3) and vimentin
#21228
high Confidence
Subject:
TTF1
(Transcription Factors)
→
is_useful_in
→
Object:
diagnostic_metastatic_breast_carcinoma_to_thyroid
(Diagnostic Process)
Original: Immunomarkers/ such as GATA-3/ hormonal marker(s)/ PAX-8/ and TTF-1#may be useful in#diagnosing metastatic breast carcinoma to the thyroid
#21227
high Confidence
Subject:
PAX8
(Transcription Factors)
→
is_useful_in
→
Object:
diagnostic_metastatic_breast_carcinoma_to_thyroid
(Diagnostic Process)
Original: Immunomarkers/ such as GATA-3/ hormonal marker(s)/ PAX-8/ and TTF-1#may be useful in#diagnosing metastatic breast carcinoma to the thyroid
#21226
high Confidence
Subject:
GATA3
(Transcription Factors)
→
is_useful_in
→
Object:
diagnostic_metastatic_breast_carcinoma_to_thyroid
(Diagnostic Process)
Original: Immunomarkers/ such as GATA-3/ hormonal marker(s)/ PAX-8/ and TTF-1#may be useful in#diagnosing metastatic breast carcinoma to the thyroid
#21225
high Confidence
Subject:
Metastatic_ductal_carcinoma_of_the_breast
(Tumor)
→
metastasized_to
→
Object:
thyroid_gland
(organ)
Original: Metastatic ductal carcinoma of the breast#metastasized to#thyroid gland
#21224
high Confidence
Subject:
FNA_biopsy
(Cytological detection technology)
→
diagnoses
→
Object:
LPA
(Disease phenotype)
Original: LPA#can be accurately diagnosed by#FNA biopsy
#21223
high Confidence
Subject:
ultrasound-guided needle biopsy
(Diagnostic techniques)
→
is_performed_in
→
Object:
prostatic carcinoma
(Tumor type)
Original: ultrasound-guided needle biopsies#were carried out in#50 clinically suspicious cases of prostatic carcinoma
#21222
high Confidence
Subject:
Immunohistochemical study
(Diagnostic techniques)
→
is_useful_for
→
Object:
diagnosis of rhabdomyosarcoma
(Diagnostic Process)
Original: immunohistochemical study#is useful for#diagnosis of rhabdomyosarcoma
#21221
high Confidence
Subject:
myoepithelial carcinoma
(Tumor type)
→
is_confirmed_by
→
Object:
smooth muscle actin
(protein)
Original: myoepithelial carcinoma#is confirmed by#positive immunohistochemical staining for S100 protein/ epithelial membrane antigen/ and smooth muscle actin
#21220
high Confidence
Subject:
myoepithelial carcinoma
(Tumor type)
→
is_confirmed_by
→
Object:
epithelial membrane antigen
(protein)
Original: myoepithelial carcinoma#is confirmed by#positive immunohistochemical staining for S100 protein/ epithelial membrane antigen/ and smooth muscle actin
#21219
high Confidence
Subject:
myoepithelial carcinoma
(Tumor type)
→
is_confirmed_by
→
Object:
S100 protein
(protein)
Original: myoepithelial carcinoma#is confirmed by#positive immunohistochemical staining for S100 protein/ epithelial membrane antigen/ and smooth muscle actin
#21218
high Confidence
Subject:
Fine-needle_aspiration
(Diagnostic techniques)
→
is_routinely_performed_in
→
Object:
osseous_lesions
(Bone lesions)
Original: Fine-needle aspiration (FNA)#is routinely performed in#osseous lesions
#21217
high Confidence
Subject:
IDH2_R172_mutation
(Gene mutation)
→
occurs_in
→
Object:
large_cell_neuroendocrine_carcinoma
(Tumor type)
Original: IDH2 R172 mutations#occur in#sinonasal undifferentiated carcinoma (SNUC)/ large-cell neuroendocrine carcinoma (LCNEC)/ sinonasal adenocarcinomas/ and olfactory neuroblastoma (ONB)
#21216
high Confidence
Subject:
IDH2_R172_mutation
(Gene mutation)
→
occurs_in
→
Object:
sinonasal_undifferentiated_carcinoma
(Tumor type)
Original: IDH2 R172 mutations#occur in#sinonasal undifferentiated carcinoma (SNUC)/ large-cell neuroendocrine carcinoma (LCNEC)/ sinonasal adenocarcinomas/ and olfactory neuroblastoma (ONB)
#21215
high Confidence
Subject:
triple_negative_breast_cancer
(Tumor type)
→
is_negative_for
→
Object:
HER2
(Receptor protein)
Original: Triple-negative breast cancer (TNBC)#is negative for#HER2
#21214
high Confidence
Subject:
triple_negative_breast_cancer
(Tumor type)
→
lacks
→
Object:
progesterone_receptor
(Receptor protein)
Original: Triple-negative breast cancer (TNBC)#lacks#estrogen and progesterone receptors
#21213
high Confidence
Subject:
triple_negative_breast_cancer
(Tumor type)
→
lacks
→
Object:
estrogen_receptor
(Receptor protein)
Original: Triple-negative breast cancer (TNBC)#lacks#estrogen and progesterone receptors
#21212
high Confidence
Subject:
prostatic_carcinoma
(disease)
→
showed
→
Object:
prostatic_acid_phosphatase
(protein)
Original: Prostatic carcinoma cases#showed#PSA and prostatic acid phosphatase immunoreactivity
#21211
high Confidence
Subject:
prostatic_carcinoma
(disease)
→
showed
→
Object:
PSA
(protein)
Original: Prostatic carcinoma cases#showed#PSA and prostatic acid phosphatase immunoreactivity
#21210
high Confidence
Subject:
histological_ultrastructural_and_immunohistochemical_features
(Diagnosis)
→
are_essential_for
→
Object:
diagnosis
(diagnosis)
Original: Histological/ ultrastructural/ and immunohistochemical features#are essential for#diagnosis
#21209
high Confidence
Subject:
differential_diagnosis
(Diagnostic Process)
→
was_based_on
→
Object:
cytological_features_of_tumor_cells
(Cell morphology)
Original: differential diagnosis#was based on#cytological features of tumor cells
#21208
high Confidence
Subject:
histology
(Histological detection technology)
→
Reports
→
Object:
amelanotic_malignant_melanoma
(disease)
Original: histology#reported#amelanotic malignant melanoma
#21207
high Confidence
Subject:
fine-needle_aspiration_cytology
(Cytological detection technology)
→
diagnoses
→
Object:
amelanotic_melanoma_recurrence
(Disease recurrence)
Original: amelanotic melanoma recurrence#was diagnosed by#fine-needle aspiration cytology
#21206
high Confidence
Subject:
Malignant_granular_cell_tumor
(Tumor type)
→
was_diagnosed_using
→
Object:
histological_criteria_by_Fanburg-Smith
(Diagnostic criteria)
Original: Malignant granular cell tumor#was diagnosed using#histological criteria established by Fanburg-Smith et al.
#21205
high Confidence
Subject:
immunohistochemical_finding
(Immunohistochemical findings)
→
led_to
→
Object:
diagnosis_of_borderline_clear_cell_adenofibroma
(Diagnosis conclusion)
Original: Characteristic morphologic and immunohistochemical findings#led to#a diagnosis of borderline clear cell adenofibroma
#21204
high Confidence
Subject:
morphologic_finding
(Morphological findings)
→
led_to
→
Object:
diagnosis_of_borderline_clear_cell_adenofibroma
(Diagnosis conclusion)
Original: Characteristic morphologic and immunohistochemical findings#led to#a diagnosis of borderline clear cell adenofibroma
#21203
high Confidence
Subject:
CT_scan
(Imaging Technology)
→
shows
→
Object:
right_ovarian_mass
(Lump)
Original: Ultrasound and CT scans#showed#a right ovarian mass 8 cm in diameter
#21202
high Confidence
Subject:
ultrasound
(Imaging Technology)
→
shows
→
Object:
right_ovarian_mass
(Lump)
Original: Ultrasound and CT scans#showed#a right ovarian mass 8 cm in diameter
#21201
high Confidence
Subject:
tumor
(Tumor type)
→
shows_strong_immunoreactivity_for
→
Object:
neuron_specific_enolase
(Enzymes)
Original: Tumors#showed#strong immunoreactivity for neuron-specific enolase
#21200
high Confidence
Subject:
ductal_carcinoma_in_situ
(Tumor type)
→
is_characterized_by
→
Object:
cribriform_pattern
(Organizational Structure)
Original: Ductal carcinoma in situ#is characterized by#small and uniform tumor cells growing in a cribriform pattern without comedo necrosis
#21199
high Confidence
Subject:
ductal_carcinoma_in_situ
(Tumor type)
→
is_characterized_by
→
Object:
small_uniform_tumor_cells
(Cell morphology)
Original: Ductal carcinoma in situ#is characterized by#small and uniform tumor cells growing in a cribriform pattern without comedo necrosis
#21198
high Confidence
Subject:
immunohistochemical_technique
(Detection Technology)
→
assists_in
→
Object:
differential_diagnosis_of_MRT
(Diagnosis conclusion)
Original: Immunohistochemical techniques#assist in#differential diagnosis of MRT against other childhood round-cell tumors
#21197
high Confidence
Subject:
immunohistochemical_pattern
(Detection Mode)
→
permits
→
Object:
diagnosis_of_MRT
(Diagnosis conclusion)
Original: Immunohistochemical pattern#permits#a confident diagnosis of MRT
#21196
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
alpha_1_antichymotrypsin
(Protease inhibitors)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21195
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
LCA
(common leukocyte antigen)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21194
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
myoglobin
(Cytoskeletal proteins)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21193
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
NSE
(Neuron-specific enolase)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21192
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
S-100_protein
(Cytoskeletal proteins)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21191
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
desmin
(Cytoskeletal proteins)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21190
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_positive_for
→
Object:
keratin
(Cytoskeletal proteins)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21189
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_positive_for
→
Object:
vimentin
(Cytoskeletal proteins)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21188
high Confidence
Subject:
Pancreatic_tumor
(Tumor type)
→
exhibits
→
Object:
Papillary-cystic_microscopic_morphology
(Histological morphology)
Original: Unusual pancreatic tumor#exhibits#a characteristic papillary-cystic microscopic morphology
#21187
high Confidence
Subject:
lung_adenocarcinoma
(disease)
→
is_associated_with
→
Object:
KRAS_mutational_status
(Gene mutation)
Original: Lung adenocarcinomas#are associated with#EGFR and KRAS mutational status
#21186
high Confidence
Subject:
lung_adenocarcinoma
(disease)
→
is_associated_with
→
Object:
EGFR_mutational_status
(Gene mutation)
Original: Lung adenocarcinomas#are associated with#EGFR and KRAS mutational status
#21185
high Confidence
Subject:
lung_adenocarcinoma
(disease)
→
is_diagnosed_by
→
Object:
cytologic_methods
(Diagnostic techniques)
Original: Lung adenocarcinomas#are diagnosed by#cytologic methods
#21184
high Confidence
Subject:
ACD-associated_RCC
(disease)
→
is_recognized_as
→
Object:
distinct_entity
(Disease classification)
Original: ACD-associated RCC#is recognized as#a distinct entity
#21183
high Confidence
Subject:
SMARCB1_mutations
(Gene mutation)
→
confirm
→
Object:
SMARCB1_deficiency
(Loss of gene function)
Original: SMARCB1 mutations#confirm#SMARCB1-deficiency
#21182
high Confidence
Subject:
Anaplastic_carcinoma_of_the_thyroid
(Tumor type)
→
is_diagnosed_in
→
Object:
thyroid_aspirates
(Clinical samples)
Original: Anaplastic carcinoma of the thyroid#is diagnosed in#1/519 thyroid aspirates
#21181
high Confidence
Subject:
Lacunar type Reed-Sternberg cells
(Cell Type)
→
are_positive_for
→
Object:
CD15
(Protein markers)
Original: Lacunar type Reed-Sternberg cells#were positive for#CD30 and CD15
#21180
high Confidence
Subject:
Lacunar type Reed-Sternberg cells
(Cell Type)
→
are_positive_for
→
Object:
CD30
(Protein markers)
Original: Lacunar type Reed-Sternberg cells#were positive for#CD30 and CD15
#21179
high Confidence
Subject:
Cells
(cell)
→
were_negative_for
→
Object:
terminal_deoxynucleotidyl_transferase
(Enzymes)
Original: Cells#were negative for#CD34 and terminal deoxynucleotidyl transferase
#21178
high Confidence
Subject:
Cells
(cell)
→
were_negative_for
→
Object:
CD34
(Cell surface markers)
Original: Cells#were negative for#CD34 and terminal deoxynucleotidyl transferase
#21177
high Confidence
Subject:
Cells
(cell)
→
were_positive_for
→
Object:
CD20
(Cell surface markers)
Original: Cells#were positive for#CD19/ CD22/ and low-density CD20
#21176
high Confidence
Subject:
Cells
(cell)
→
were_positive_for
→
Object:
CD22
(Cell surface markers)
Original: Cells#were positive for#CD19/ CD22/ and low-density CD20
#21175
high Confidence
Subject:
Cells
(cell)
→
were_positive_for
→
Object:
CD19
(Cell surface markers)
Original: Cells#were positive for#CD19/ CD22/ and low-density CD20
#21174
high Confidence
Subject:
Fine_needle_aspiration_cytology
(Diagnostic techniques)
→
diagnosis_of
→
Object:
granular_cell_tumor
(Tumor diseases)
Original: Fine needle aspiration cytology (FNAC)#diagnosis of#granular cell tumor (GCT)
#21173
high Confidence
Subject:
HHV-8
(Virus)
→
was_proven_by
→
Object:
immunocytochemistry
(Diagnostic techniques)
Original: Positivity for HHV-8#was proven by#immunocytochemistry
#21172
high Confidence
Subject:
diffuse_midline_glioma
(Tumor type)
→
occurs_less_frequently_in
→
Object:
adults
(Demographic characteristics)
Original: diffuse midline glioma#occurs primarily in#children and less frequently in adults
#21171
high Confidence
Subject:
diffuse_midline_glioma
(Tumor type)
→
occurs_primarily_in
→
Object:
children
(Demographic characteristics)
Original: diffuse midline glioma#occurs primarily in#children and less frequently in adults
#21170
high Confidence
Subject:
fluorine_18_fluorodeoxyglucose_PET
(Molecular imaging technology)
→
demonstrated
→
Object:
complete_response
(Response to treatment)
Original: fluorine-18 fluorodeoxyglucose positron emission tomography#demonstrated#complete response
#21169
high Confidence
Subject:
EWSR1
(Protein coding genes)
→
undergoes
→
Object:
gene_rearrangement
(Genetic variation)
Original: EWSR1 gene#undergoes#a rearrangement
#21168
high Confidence
Subject:
PET-CT
(Imaging Technology)
→
showed
→
Object:
vertebral_involvement
(Bone tissue lesions)
Original: PET-CT#showed#bilateral renal swelling/ splenic enlargement/ and vertebral involvement
#21167
high Confidence
Subject:
PET-CT
(Imaging Technology)
→
showed
→
Object:
splenic_enlargement
(Organ lesions)
Original: PET-CT#showed#bilateral renal swelling/ splenic enlargement/ and vertebral involvement
#21166
high Confidence
Subject:
PET-CT
(Imaging Technology)
→
showed
→
Object:
bilateral_renal_swelling
(Organ lesions)
Original: PET-CT#showed#bilateral renal swelling/ splenic enlargement/ and vertebral involvement
#21165
high Confidence
Subject:
ISSVD
(medical society)
→
recommends_not_to_use
→
Object:
grading_for_VIN
(Clinical classification)
Original: ISSVD#recommends not to use#a grading for VIN
#21164
high Confidence
Subject:
Calculation
(Pathological characteristics)
→
supports
→
Object:
diagnosis_of_pilomatrixoma
(Disease diagnosis)
Original: presence of foreign body-type giant cells/ nucleated squamous cells/ and calcification#supported#a diagnosis of pilomatrixoma
#21163
high Confidence
Subject:
nucleated_squamous_cells
(Epithelial cells)
→
supports
→
Object:
diagnosis_of_pilomatrixoma
(Disease diagnosis)
Original: presence of foreign body-type giant cells/ nucleated squamous cells/ and calcification#supported#a diagnosis of pilomatrixoma
#21162
high Confidence
Subject:
foreign_body-type_giant_cells
(Histiocytes)
→
supports
→
Object:
diagnosis_of_pilomatrixoma
(Disease diagnosis)
Original: presence of foreign body-type giant cells/ nucleated squamous cells/ and calcification#supported#a diagnosis of pilomatrixoma
#21161
high Confidence
Subject:
ghost_cells
(Tumor cells)
→
presence_in_FNA_smears_is_sufficient_for
→
Object:
confident_cytologic_diagnosis_of_pilomatrixoma
(Diagnosis conclusion)
Original: presence of basaloid cells and ghost cells in FNA smears#was sufficient for#a confident cytologic diagnosis of pilomatrixoma
#21160
high Confidence
Subject:
basaloid_cells
(Tumor cells)
→
presence_in_FNA_smears_is_sufficient_for
→
Object:
confident_cytologic_diagnosis_of_pilomatrixoma
(Diagnosis conclusion)
Original: presence of basaloid cells and ghost cells in FNA smears#was sufficient for#a confident cytologic diagnosis of pilomatrixoma
#21159
high Confidence
Subject:
multilobated_and_ground-glass_nuclei
(Nuclear morphology)
→
is_marker_of
→
Object:
thyroid_papillary_carcinoma
(Tumor diseases)
Original: The presence of multilobated and ground-glass nuclei#is#a typical histological marker of thyroid papillary carcinoma
#21158
high Confidence
Subject:
CD17
(Cell surface molecules)
→
exhibits
→
Object:
negative_immunohistochemical_finding
(Immunohistochemical characteristics)
Original: CD 17#exhibits#negative immunohistochemical findings
#21157
high Confidence
Subject:
AE1/AE3
(Cytokeratin complex)
→
exhibits
→
Object:
negative_immunohistochemical_finding
(Immunohistochemical characteristics)
Original: AE1/AE3#exhibits#negative immunohistochemical findings
#21156
high Confidence
Subject:
HMB-45
(protein)
→
exhibits
→
Object:
positive_immunohistochemical_finding
(Immunohistochemical characteristics)
Original: HMB-45#exhibits#positive immunohistochemical findings
#21155
high Confidence
Subject:
Melan_A
(protein)
→
exhibits
→
Object:
positive_immunohistochemical_finding
(Immunohistochemical characteristics)
Original: Melan A#exhibits#positive immunohistochemical findings
#21154
high Confidence
Subject:
protein_S-100
(protein)
→
exhibits
→
Object:
positive_immunohistochemical_finding
(Immunohistochemical characteristics)
Original: protein S-100#exhibits#positive immunohistochemical findings
#21153
high Confidence
Subject:
vimentin
(Intermediate filament protein)
→
exhibits
→
Object:
positive_immunohistochemical_finding
(Immunohistochemical characteristics)
Original: vimentin#exhibits#positive immunohistochemical findings
#21152
high Confidence
Subject:
Burkitt's_lymphoma
(Malignant tumors)
→
is_characterized_as
→
Object:
highly_aggressive_mature_B-cell_neoplasm
(Tumor phenotype)
Original: Burkitt's lymphoma#is characterized as#a highly aggressive mature B-cell neoplasm
#21151
high Confidence
Subject:
CIC
(Protein coding genes)
→
oncogenic_fusion_with
→
Object:
DUX4L
(Protein coding genes)
Original: Undifferentiated round cell sarcomas#are defined by#oncogenic fusion of CIC and either DUX4 or DUX4L
#21150
high Confidence
Subject:
CIC
(Protein coding genes)
→
oncogenic_fusion_with
→
Object:
DUX4
(Protein coding genes)
Original: Undifferentiated round cell sarcomas#are defined by#oncogenic fusion of CIC and either DUX4 or DUX4L
#21149
high Confidence
Subject:
tumor_cells
(Cell Type)
→
stained_with
→
Object:
anti_NSE_polyclonal_antibody
(Antibody)
Original: Tumor cells#stained with#anti-NSE polyclonal antibody
#21148
high Confidence
Subject:
tumor_cells
(Cell Type)
→
stained_negative_for
→
Object:
CD45_RO
(Protein molecules)
Original: Tumor cells#stained positive for#CD20 but not for CD45 RO
#21147
high Confidence
Subject:
tumor_cells
(Cell Type)
→
stained_positive_for
→
Object:
CD20
(Protein molecules)
Original: Tumor cells#stained positive for#CD20 but not for CD45 RO
#21146
high Confidence
Subject:
special_histopathological_staining
(Detection Technology)
→
demonstrated
→
Object:
small_yeast_cells_with_narrow_base_budding
(microorganism)
Original: Special histopathological staining#demonstrated#the presence of small yeast cells with simple and narrow-base budding compatible with Sporothrix schenckii
#21145
high Confidence
Subject:
Primary_plasma_cell_leukemia
(disease)
→
is
→
Object:
highly_aggressive_plasma_cell_malignancy
(Disease Type)
Original: Primary plasma cell leukemia#is#a rare and highly aggressive plasma cell malignancy
#21144
high Confidence
Subject:
Primary_plasma_cell_leukemia
(disease)
→
is
→
Object:
rare_plasma_cell_malignancy
(Disease Type)
Original: Primary plasma cell leukemia#is#a rare and highly aggressive plasma cell malignancy
#21143
high Confidence
Subject:
atypical_adenomatous_hyperplasia_of_prostate
(Preneoplastic lesions)
→
is_characterized_by
→
Object:
morphologic_criteria
(Morphological criteria)
Original: Atypical adenomatous hyperplasia of the prostate#is characterized by#morphologic criteria
#21142
high Confidence
Subject:
epithelioid_angiosarcoma_of_vagina
(Tumor type)
→
is
→
Object:
rare_variant
(Tumor subtype)
Original: Epithelioid angiosarcoma of the vagina#is#a rare variant
#21141
high Confidence
Subject:
metastatic_seminoma
(Tumor type)
→
diagnosed_as
→
Object:
spermatocytic_subtype
(Tumor subtype)
Original: a metastatic seminoma in a hedgehog#is diagnosed as#spermatocytic subtype
#21140
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
expresses
→
Object:
CD117
(Receptor protein)
Original: Neoplastic cells#were positive for#CD117 by immunohistochemistry
#21139
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD138
(Membrane protein markers)
Original: Tumor cells#were positive for#CD79a and CD138
#21138
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD79A
(Membrane protein markers)
Original: Tumor cells#were positive for#CD79a and CD138
#21137
high Confidence
Subject:
surgical_removal
(Treatment)
→
confirms
→
Object:
adrenal_carcinoma
(Tumor type)
Original: Surgical removal#confirmed#diagnosis of adrenal carcinoma
#21136
high Confidence
Subject:
solid-papillary_carcinoma_of_the_breast
(Tumor type)
→
is_variant_of
→
Object:
low-grade_intraductal_carcinoma
(Tumor type)
Original: Solid-papillary carcinoma (SPC) of the breast#is#a rare variant of low-grade intraductal carcinoma
#21135
high Confidence
Subject:
Polymorphous_adenocarcinoma-associated_genetic_alterations
(Genomic variation)
→
are_common_in
→
Object:
polymorphous_adenocarcinomas
(Adenocarcinoma)
Original: Polymorphous adenocarcinoma-associated genetic alterations#were disclosed as#common and specific findings in polymorphous adenocarcinomas
#21134
high Confidence
Subject:
ARID1A_split_positivity
(Gene disruption)
→
is_risk_factor_for
→
Object:
disease-free_survival
(Prognosis)
Original: ARID1A split positivity#was identified as#an independent risk factor for disease-free survival
#21133
high Confidence
Subject:
PRKD1_E710D_mutation
(Gene mutation)
→
was_identified_in
→
Object:
polymorphous_adenocarcinoma_cases
(Adenocarcinoma)
Original: PRKD1 E710D mutation#was identified in#4 cases (11.1%)
#21132
high Confidence
Subject:
intranuclear_inclusions
(Nuclear inclusions)
→
is_associated_with
→
Object:
papillary_carcinoma
(Tumor type)
Original: Intranuclear inclusions/ papillary and/or sheet arrangements/ nuclear grooves/ powdery chromatin/ nuclear molding/ high cellularity/ and small nucleoli#were significantly associated with#papillary carcinoma
#21131
high Confidence
Subject:
SMARCA4_deficiency
(Loss of gene function)
→
is_associated_with
→
Object:
esophageal_carcinoma
(Tumor type)
Original: Esophageal carcinoma#is associated with#SMARCA4 deficiency or dysfunction
#21130
high Confidence
Subject:
MYB-NFIB_translocation
(Gene fusion)
→
is_common_in
→
Object:
ACC
(Tumor type)
Original: MYB-NFIB translocation#is common in#ACC
#21129
high Confidence
Subject:
open_chromatin
(Chromatin open state)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: open chromatin#is identified as#adverse prognostic factor of RFS
#21128
high Confidence
Subject:
nuclear_atypia
(Nuclear atypia in tumor cells)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: nuclear atypia#is identified as#adverse prognostic factor of RFS
#21127
high Confidence
Subject:
vascular_invasion
(Tumor vascular invasion)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: vascular invasion#is identified as#adverse prognostic factor of RFS
#21126
high Confidence
Subject:
high_grade_transformation
(Tumor grade characteristics)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: high-grade transformation#is identified as#adverse prognostic factor of RFS
#21125
high Confidence
Subject:
positive_margin
(Surgical margin characteristics)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: positive margin#is identified as#adverse prognostic factor of RFS
#21124
high Confidence
Subject:
increased_mitoses
(Tumor cell proliferation characteristics)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: increased mitoses#is identified as#adverse prognostic factor of RFS
#21123
high Confidence
Subject:
solid_growth_pattern
(Tumor Histological Characteristics)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: solid growth pattern#is identified as#adverse prognostic factor of RFS
#21122
high Confidence
Subject:
large_tumor_size
(Tumor phenotypic characteristics)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: large tumor size#is identified as#adverse prognostic factor of RFS
#21121
high Confidence
Subject:
nine_cytologic_features
(Cytological characteristics)
→
are_significantly_associated_with
→
Object:
HCC
(disease)
Original: Nine cytologic features#are significantly associated with#HCC
#21120
high Confidence
Subject:
stepwise_logistic_regression_analysis
(Statistical analysis methods)
→
selects
→
Object:
useful_cytologic_features_for_discriminating_HCC
(Diagnostic features)
Original: Step-wise logistic regression analysis#selects#useful cytologic features for discriminating HCC
#21119
high Confidence
Subject:
fine_needle_aspiration_smears
(Cytological testing methods)
→
are_used_to_detect
→
Object:
cytologic_changes_associated_with_HCC
(Cytological changes)
Original: Fine needle aspiration (FNA) smears#are used to detect#cytologic changes associated with HCC
#21118
high Confidence
Subject:
epithelial_cells
(Epithelial cells)
→
are_stained_with
→
Object:
antibodies_against_cytokeratin
(Antibody staining)
Original: Epithelial cells#were stained with#antibodies against vimentin and cytokeratin
#21117
high Confidence
Subject:
epithelial_cells
(Epithelial cells)
→
are_stained_with
→
Object:
antibodies_against_vimentin
(Antibody staining)
Original: Epithelial cells#were stained with#antibodies against vimentin and cytokeratin
#21116
high Confidence
Subject:
epithelial_cells
(Epithelial cells)
→
are_nonimmunoreactive_for
→
Object:
parathyroid_hormone
(hormone)
Original: Epithelial cells#were immunoreactive for#cytokeratin and nonimmunoreactive for vimentin/ S-100/ chromogranin/ and parathyroid hormone
#21115
high Confidence
Subject:
epithelial_cells
(Epithelial cells)
→
are_nonimmunoreactive_for
→
Object:
Chromogranin
(Secretory granule protein)
Original: Epithelial cells#were immunoreactive for#cytokeratin and nonimmunoreactive for vimentin/ S-100/ chromogranin/ and parathyroid hormone
#21114
high Confidence
Subject:
epithelial_cells
(Epithelial cells)
→
are_nonimmunoreactive_for
→
Object:
S-100
(Calcium Binding Protein)
Original: Epithelial cells#were immunoreactive for#cytokeratin and nonimmunoreactive for vimentin/ S-100/ chromogranin/ and parathyroid hormone
#21113
high Confidence
Subject:
epithelial_cells
(Epithelial cells)
→
are_nonimmunoreactive_for
→
Object:
vimentin
(Structural proteins)
Original: Epithelial cells#were immunoreactive for#cytokeratin and nonimmunoreactive for vimentin/ S-100/ chromogranin/ and parathyroid hormone
#21112
high Confidence
Subject:
epithelial_cells
(Epithelial cells)
→
are_immunoreactive_for
→
Object:
cytokeratin
(Structural proteins)
Original: Epithelial cells#were immunoreactive for#cytokeratin and nonimmunoreactive for vimentin/ S-100/ chromogranin/ and parathyroid hormone
#21111
high Confidence
Subject:
neoplastic_cell_nuclei
(Nucleus)
→
express
→
Object:
Ki67
(Proliferation markers)
Original: The nuclei of many neoplastic cells#expressed#the proliferation marker Ki67
#21110
high Confidence
Subject:
cell_block_sections
(Pathological technology)
→
provide
→
Object:
histologic_confirmation
(Diagnosis confirmation)
Original: Cell block sections#provide#histologic confirmation
#21109
high Confidence
Subject:
Neuroendocrine_differentiation_in_LCNEC
(Differentiation characteristics)
→
was_confirmed_by
→
Object:
immunohistochemistry_for_CD56
(Immunohistochemistry)
Original: Neuroendocrine differentiation in LCNEC#was confirmed by#immunohistochemistry for synaptophysin and CD56
#21108
high Confidence
Subject:
Neuroendocrine_differentiation_in_LCNEC
(Differentiation characteristics)
→
was_confirmed_by
→
Object:
immunohistochemistry_for_synaptophysin
(Immunohistochemistry)
Original: Neuroendocrine differentiation in LCNEC#was confirmed by#immunohistochemistry for synaptophysin and CD56
#21107
high Confidence
Subject:
Histologic_examination
(Pathological technology)
→
revealed
→
Object:
LCNEC
(Tumor type)
Original: Histologic examination#revealed#LCNEC with minor foci of SmCC
#21106
high Confidence
Subject:
Uterine_endometrium_curettage
(Pathological technology)
→
revealed
→
Object:
endometrioid_adenocarcinoma
(Tumor type)
Original: Uterine endometrium curettage#revealed#endometrioid adenocarcinoma with squamous differentiation
#21105
high Confidence
Subject:
adenocarcinoma_cytology
(Tumor cell morphology)
→
promotes
→
Object:
ROS1_immunohistochemistry_testing
(Molecular detection methods)
Original: Specific histology of adenocarcinoma on cytological materials#should promote#testing for ROS1 immunohistochemistry
#21104
high Confidence
Subject:
fine-needle_aspiration_biopsy
(Diagnostic Tools)
→
is_used_for
→
Object:
diagnosis_of_high-grade_pulmonary_neuroendocrine_carcinoma
(Disease diagnosis)
Original: fine-needle aspiration biopsy#is used for#diagnosis of high-grade pulmonary neuroendocrine carcinoma
#21103
high Confidence
Subject:
patients_with_ccRCC
(patient)
→
underwent
→
Object:
partial_nephrectomy
(Surgery)
Original: 3865 patients#underwent#radical or partial nephrectomy for unilateral/ sporadic ccRCC
#21102
high Confidence
Subject:
patients_with_ccRCC
(patient)
→
underwent
→
Object:
radical_nephrectomy
(Surgery)
Original: 3865 patients#underwent#radical or partial nephrectomy for unilateral/ sporadic ccRCC
#21101
high Confidence
Subject:
RCC
(Kidney Cancer Subtypes)
→
is_classified_as
→
Object:
subtype_of_low_grade_cystic_renal_epithelial_neoplasms
(Tumor subtype)
Original: ccpRCC#is classified as#a subtype of low grade cystic renal epithelial neoplasms
#21100
high Confidence
Subject:
ccRCC
(Kidney Cancer Subtypes)
→
is_classified_as
→
Object:
subtype_of_low_grade_cystic_renal_epithelial_neoplasms
(Tumor subtype)
Original: ccRCC#is classified as#a subtype of low grade cystic renal epithelial neoplasms
#21099
high Confidence
Subject:
MCLMP
(Tumor subtype)
→
is_classified_as
→
Object:
subtype_of_low_grade_cystic_renal_epithelial_neoplasms
(Tumor subtype)
Original: MCLMP#is classified as#a subtype of low grade cystic renal epithelial neoplasms
#21098
high Confidence
Subject:
solid_variant_of_papillary_thyroid_carcinoma
(Tumor subtype)
→
is
→
Object:
rare_subtype_of_papillary_thyroid_carcinoma
(Tumor subtype)
Original: solid variant of papillary thyroid carcinoma (PTCSC)#is#a rare subtype of papillary thyroid carcinoma (PTC)
#21097
high Confidence
Subject:
primary_oncocytic_carcinoma
(Tumor diseases)
→
occurs_in
→
Object:
salivary_glands
(Glandular tissue)
Original: Primary oncocytic carcinoma#occurs in#salivary glands
#21096
high Confidence
Subject:
final_diagnosis
(Diagnosis conclusion)
→
is
→
Object:
miscellaneous
(other)
Original: final diagnoses#were#cancer (69%)/ benign (13%)/ atypical but not diagnostic (10%)/ high-grade PIN (5%)/ miscellaneous (3%)
#21095
high Confidence
Subject:
final_diagnosis
(Diagnosis conclusion)
→
is
→
Object:
high-grade_PIN
(High-grade prostatic intraepithelial neoplasia)
Original: final diagnoses#were#cancer (69%)/ benign (13%)/ atypical but not diagnostic (10%)/ high-grade PIN (5%)/ miscellaneous (3%)
#21094
high Confidence
Subject:
final_diagnosis
(Diagnosis conclusion)
→
is
→
Object:
atypical_condition
(Atypical diseases)
Original: final diagnoses#were#cancer (69%)/ benign (13%)/ atypical but not diagnostic (10%)/ high-grade PIN (5%)/ miscellaneous (3%)
#21093
high Confidence
Subject:
final_diagnosis
(Diagnosis conclusion)
→
is
→
Object:
benign_condition
(Benign diseases)
Original: final diagnoses#were#cancer (69%)/ benign (13%)/ atypical but not diagnostic (10%)/ high-grade PIN (5%)/ miscellaneous (3%)
#21092
high Confidence
Subject:
final_diagnosis
(Diagnosis conclusion)
→
is
→
Object:
cancer
(disease)
Original: final diagnoses#were#cancer (69%)/ benign (13%)/ atypical but not diagnostic (10%)/ high-grade PIN (5%)/ miscellaneous (3%)
#21091
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
are_positive_to
→
Object:
Alpha-actin
(Cytoskeletal proteins)
Original: Neoplastic cells#were positive to#vimentin/ actin/ and alpha-actin
#21090
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
are_positive_to
→
Object:
Actin
(Cytoskeletal proteins)
Original: Neoplastic cells#were positive to#vimentin/ actin/ and alpha-actin
#21089
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
are_positive_to
→
Object:
Vimentin
(Cytoskeletal proteins)
Original: Neoplastic cells#were positive to#vimentin/ actin/ and alpha-actin
#21088
high Confidence
Subject:
CIC-rearranged sarcomas
(Tumor type)
→
are_distinct_from
→
Object:
Ewing sarcomas
(Tumor type)
Original: CIC-rearranged sarcomas#are distinct from#Ewing sarcomas
#21087
high Confidence
Subject:
primary_carcinoid_tumor
(Tumor type)
→
is_extremely_rare_in
→
Object:
urinary_bladder
(organ)
Original: Primary carcinoid tumor#is extremely rare in#urinary bladder
#21086
high Confidence
Subject:
Stage_III_or_IV_disease
(Patient stratification)
→
is_associated_with
→
Object:
patient_death
(Disease phenotype)
Original: Stage III or IV disease#is significantly associated with#tumor recurrence or patient's death
#21085
high Confidence
Subject:
Stage_III_or_IV_disease
(Patient stratification)
→
is_associated_with
→
Object:
tumor_recurrence
(Disease phenotype)
Original: Stage III or IV disease#is significantly associated with#tumor recurrence or patient's death
#21084
high Confidence
Subject:
older_age
(Age Factor)
→
is_significantly_associated_with
→
Object:
patient_death
(Disease Outcome)
Original: Older age#is significantly associated with#tumor recurrence or patient's death
#21083
high Confidence
Subject:
older_age
(Age Factor)
→
is_significantly_associated_with
→
Object:
tumor_recurrence
(Disease Outcome)
Original: Older age#is significantly associated with#tumor recurrence or patient's death
#21082
high Confidence
Subject:
neuroendocrine_carcinoma
(Neuroendocrine cancer)
→
includes
→
Object:
atypical_carcinoid_tumor
(Tumor subtype)
Original: Low- and intermediate-grade neuroendocrine carcinoma#includes#typical and atypical carcinoid tumors
#21081
high Confidence
Subject:
neuroendocrine_carcinoma
(Neuroendocrine cancer)
→
includes
→
Object:
typical_carcinoid_tumor
(Tumor subtype)
Original: Low- and intermediate-grade neuroendocrine carcinoma#includes#typical and atypical carcinoid tumors
#21080
high Confidence
Subject:
gastric_carcinoma
(Malignant tumors)
→
is_one_of
→
Object:
most_common_cancers_worldwide
(Disease epidemiology)
Original: Gastric carcinoma#is one of#the most common cancers worldwide
#21079
high Confidence
Subject:
Primary_cutaneous_diffuse_large_B_cell_lymphoma_leg_type
(disease)
→
is_a
→
Object:
high_grade_lymphoma
(disease)
Original: Primary cutaneous diffuse large B-cell lymphoma/ leg type#is a#high-grade lymphoma
#21078
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
tested_positive_for
→
Object:
STAT6
(Transcription Factors)
Original: tumor cells#tested positive for#STAT6
#21077
high Confidence
Subject:
Merkel_cell_carcinoma
(Tumor type)
→
is_also_known_as
→
Object:
trabecular_carcinoma_of_the_skin
(Tumor type)
Original: Merkel cell carcinoma#is also known as#neuroendocrine carcinoma of the skin or trabecular carcinoma of the skin
#21076
high Confidence
Subject:
Merkel_cell_carcinoma
(Tumor type)
→
is_also_known_as
→
Object:
neuroendocrine_carcinoma_of_the_skin
(Tumor type)
Original: Merkel cell carcinoma#is also known as#neuroendocrine carcinoma of the skin or trabecular carcinoma of the skin
#21075
high Confidence
Subject:
seminoma_cells
(Tumor cells)
→
stained_negative_for
→
Object:
cytokeratin
(Diagnostic markers)
Original: seminoma cells#stained negative for#low molecular and broad-spectrum cytokeratin
#21074
high Confidence
Subject:
IPMNs
(Cystic tumors)
→
are_characterized_by
→
Object:
GNAS_mutation
(Gene mutation)
Original: IPMNs and MCNs#are characterized by#driver mutations in KRAS/GNAS (IPMNs) and KRAS (MCNs)
#21073
high Confidence
Subject:
urinary_cytology
(Cytology)
→
is_accepted_as
→
Object:
diagnostic_tool_in_bladder_cancer
(Diagnostic Tools)
Original: urinary cytology#is accepted#as a diagnostic tool in bladder cancer detection
#21072
high Confidence
Subject:
craniopharyngiomas
(Tumor type)
→
are
→
Object:
tumors_of_the_suprasellar_area
(Anatomical location)
Original: Craniopharyngiomas#are#tumors of the suprasellar area
#21071
high Confidence
Subject:
criteria
(Diagnostic criteria)
→
permit
→
Object:
distinction_between_repair_atypia_and_carcinoma
(Diagnostic differentiation)
Original: Criteria#permit#distinction between repair atypia and carcinoma
#21070
high Confidence
Subject:
PD-L1_expression
(Protein expression)
→
is_associated_with
→
Object:
clinicopathological_characteristics
(Disease phenotype)
Original: Relationships between PD-L1 expression#and#clinicopathological characteristics
#21069
high Confidence
Subject:
abnormal_cells
(Tumor cell type)
→
strongly_positive_for
→
Object:
CD30
(Membrane receptor protein)
Original: Abnormal cells#were strongly positive for#CD30
#21068
high Confidence
Subject:
Polycythemia_Vera
(disease)
→
can_be_diagnosed_by
→
Object:
Cytology
(Cytology)
Original: PV#can be diagnosed by#cytology
#21067
high Confidence
Subject:
Blasts
(Hematopoietic cells)
→
express
→
Object:
CD34
(Cell surface markers)
Original: Blasts#express#CD45 and CD34
#21066
high Confidence
Subject:
Blasts
(Hematopoietic cells)
→
express
→
Object:
CD45
(Cell surface markers)
Original: Blasts#express#CD45 and CD34
#21065
high Confidence
Subject:
Malignant pleural effusion
(Disease phenotype)
→
is_caused_by
→
Object:
metastatic_adenocarcinoma
(Adenocarcinoma)
Original: Malignant pleural effusions#are caused by#metastatic adenocarcinoma
#21064
high Confidence
Subject:
Rosai-Dorfman_disease
(disease)
→
is_classified_as
→
Object:
histiocytic_neoplasm
(disease)
Original: Rosai-Dorfman disease#is classified as#a histiocytic neoplasm
#21063
high Confidence
Subject:
Nuclear_pseudoinclusions
(Nuclear morphology)
→
is_hallmark_of
→
Object:
papillary_thyroid_carcinoma
(Tumor type)
Original: Fine chromatin/ nuclear grooves/ and nuclear pseudoinclusions#are hallmarks of diagnosis in#papillary thyroid carcinoma
#21062
high Confidence
Subject:
Nuclear_grooves
(Nuclear morphology)
→
is_hallmark_of
→
Object:
papillary_thyroid_carcinoma
(Tumor type)
Original: Fine chromatin/ nuclear grooves/ and nuclear pseudoinclusions#are hallmarks of diagnosis in#papillary thyroid carcinoma
#21061
high Confidence
Subject:
Fine_chromatin
(Nuclear chromatin morphology)
→
is_hallmark_of
→
Object:
papillary_thyroid_carcinoma
(Tumor type)
Original: Fine chromatin/ nuclear grooves/ and nuclear pseudoinclusions#are hallmarks of diagnosis in#papillary thyroid carcinoma
#21060
high Confidence
Subject:
neuroectodermal_cells
(Neuroectodermal cells)
→
diagnosed_as
→
Object:
Ewing's_sarcoma
(Tumor type)
Original: It#was diagnosed as#Ewing's sarcoma
#21059
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
DOG1
(Cell surface proteins)
Original: The tumor cells#are being negative for#cytokeratins/ FLI1/ WT1/ DOG1 and lymphoid markers
#21058
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
WT1
(Transcription Factors)
Original: The tumor cells#are being negative for#cytokeratins/ FLI1/ WT1/ DOG1 and lymphoid markers
#21057
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
FLI1
(Transcription Factors)
Original: The tumor cells#are being negative for#cytokeratins/ FLI1/ WT1/ DOG1 and lymphoid markers
#21056
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
cytokeratins
(Cytoskeletal proteins)
Original: The tumor cells#are being negative for#cytokeratins/ FLI1/ WT1/ DOG1 and lymphoid markers
#21055
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_immunoreactive_to
→
Object:
ERG
(Transcription Factors)
Original: The tumor cells#are immunoreactive to#CD99 and ERG
#21054
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_immunoreactive_to
→
Object:
CD99
(Cell surface proteins)
Original: The tumor cells#are immunoreactive to#CD99 and ERG
#21053
high Confidence
Subject:
molecular_genotyping
(Molecular testing)
→
revealed
→
Object:
HPV_type_42_positivity
(Viral infection)
Original: Molecular genotyping#revealed#positivity for HPV type 42
#21052
high Confidence
Subject:
follow-up_biopsies
(Histological examination)
→
revealed
→
Object:
malignancy
(Malignant tumors)
Original: Follow-up biopsies#revealed#malignancy in 46 patients (51.69%)
#21051
high Confidence
Subject:
pyloric_gland_adenoma
(Tumor)
→
is
→
Object:
rare_neoplasm_of_gastrointestinal_tract
(Disease phenotype)
Original: Pyloric gland adenomas#are rare neoplasms of#the gastrointestinal tract
#21050
high Confidence
Subject:
diagnostic_criteria
(Diagnostic criteria)
→
are_well_established_for
→
Object:
separation_of_neoplasms
(Diagnostic strategy)
Original: Criteria#are well established for#separation of nodular goiter from most neoplasms
#21049
high Confidence
Subject:
diagnostic_criteria
(Diagnostic criteria)
→
are_well_established_for
→
Object:
separation_of_nodular_goiter
(Diagnostic strategy)
Original: Criteria#are well established for#separation of nodular goiter from most neoplasms
#21048
high Confidence
Subject:
ependymomas
(Tumor tissue)
→
constitute
→
Object:
CNS_tumors_in_adults
(Disease phenotype)
Original: ependymomas#constitute#1-3% of CNS tumors in adults
#21047
high Confidence
Subject:
ependymomas
(Tumor tissue)
→
constitute
→
Object:
CNS_tumors_in_children
(Disease phenotype)
Original: ependymomas#constitute#8-10% of CNS tumors in children
#21046
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
express
→
Object:
c-myc_protein
(Transcription Factors)
Original: neoplastic cells#express#c-myc protein
#21045
high Confidence
Subject:
neoplasm
(Tumor tissue)
→
stains_positively_for
→
Object:
Vs38C
(Cell surface antigens)
Original: neoplasm#stains positively for#CD45/ CD38/ MUM1/ and Vs38C
#21044
high Confidence
Subject:
neoplasm
(Tumor tissue)
→
stains_positively_for
→
Object:
MUM1
(Transcription Factors)
Original: neoplasm#stains positively for#CD45/ CD38/ MUM1/ and Vs38C
#21043
high Confidence
Subject:
neoplasm
(Tumor tissue)
→
stains_positively_for
→
Object:
CD38
(Cell surface antigens)
Original: neoplasm#stains positively for#CD45/ CD38/ MUM1/ and Vs38C
#21042
high Confidence
Subject:
neoplasm
(Tumor tissue)
→
stains_positively_for
→
Object:
CD45
(Cell surface antigens)
Original: neoplasm#stains positively for#CD45/ CD38/ MUM1/ and Vs38C
#21041
high Confidence
Subject:
lymphoid_cells
(Immune cells)
→
confirm
→
Object:
cytotoxic_T_cell_immunophenotype
(Immunophenotype)
Original: lymphoid cells#stain positive for#lymphoid markers confirming cytotoxic T-cell immunophenotype
#21040
high Confidence
Subject:
lymphoid_cells
(Immune cells)
→
stain_positive_for
→
Object:
lymphoid_markers
(Cell markers)
Original: lymphoid cells#stain positive for#lymphoid markers confirming cytotoxic T-cell immunophenotype
#21039
high Confidence
Subject:
atypical_glandular_cell_lesions
(Cytopathological abnormalities)
→
are_diagnosed_by
→
Object:
cervical_cytological_examination
(Cytology)
Original: atypical glandular cell lesions#are diagnosed by#cervical cytological examination
#21038
high Confidence
Subject:
renal_cell_carcinoma
(Renal cell carcinoma)
→
invades
→
Object:
adrenal_gland
(Adrenal glands)
Original: renal cell carcinoma (RCC)#frequently metastasizes to or invades#the adrenal gland
#21037
high Confidence
Subject:
renal_cell_carcinoma
(Renal cell carcinoma)
→
metastasizes_to
→
Object:
adrenal_gland
(Adrenal glands)
Original: renal cell carcinoma (RCC)#frequently metastasizes to or invades#the adrenal gland
#21036
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_immunoreactive_to
→
Object:
vimentin
(Intermediate filament protein)
Original: tumor cells#were immunoreactive to#cytokeratin/ calretinin/ epithelial membrane antigen (EMA)/ CA-125/ and vimentin
#21035
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_immunoreactive_to
→
Object:
CA-125
(Carbohydrate antigen)
Original: tumor cells#were immunoreactive to#cytokeratin/ calretinin/ epithelial membrane antigen (EMA)/ CA-125/ and vimentin
#21034
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_immunoreactive_to
→
Object:
EMA
(ECMA)
Original: tumor cells#were immunoreactive to#cytokeratin/ calretinin/ epithelial membrane antigen (EMA)/ CA-125/ and vimentin
#21033
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_immunoreactive_to
→
Object:
calretinin
(Calcium Binding Protein)
Original: tumor cells#were immunoreactive to#cytokeratin/ calretinin/ epithelial membrane antigen (EMA)/ CA-125/ and vimentin
#21032
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_immunoreactive_to
→
Object:
cytokeratin
(Cytoskeletal proteins)
Original: tumor cells#were immunoreactive to#cytokeratin/ calretinin/ epithelial membrane antigen (EMA)/ CA-125/ and vimentin
#21031
high Confidence
Subject:
Infiltrative_ductal_breast_carcinoma
(Invasive ductal breast cancer)
→
is_graded_by
→
Object:
biopsy_imprints
(Tissue prints)
Original: Infiltrative ductal breast carcinoma#is graded by#biopsy imprints
#21030
high Confidence
Subject:
cytological_features
(Cytological characteristics)
→
are_confirmed_by
→
Object:
Immunohistochemistry
(Immunohistochemistry)
Original: cytological features#are confirmed by#histopathology and immunohistochemistry
#21029
high Confidence
Subject:
cytological_features
(Cytological characteristics)
→
are_confirmed_by
→
Object:
histopathology
(Histopathology)
Original: cytological features#are confirmed by#histopathology and immunohistochemistry
#21028
high Confidence
Subject:
Serological_tests
(Diagnostic Methods)
→
is_essential_for
→
Object:
definitive_diagnosis
(Diagnosis conclusion)
Original: Microscopic evaluation/ immunohistochemical analysis/ and serological tests#are essential for#reaching a definitive diagnosis
#21027
high Confidence
Subject:
Antigliadin_antibody_test
(Serological testing)
→
proved
→
Object:
negative
(Negative result)
Original: Endomysial antibody and antigliadin antibody/ IgM and IgG tests#proved#negative
#21026
high Confidence
Subject:
Endomysial_antibody_test
(Serological testing)
→
proved
→
Object:
negative
(Negative result)
Original: Endomysial antibody and antigliadin antibody/ IgM and IgG tests#proved#negative
#21025
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
CD30
(Immune molecular markers)
Original: Tumor cells#were#CD45+/ CD3+/ CD4+/ CD8+/ CD56+/ Pan-Cytokeratin-/ CD20-/ CD79a-/ CD5-/ CD30-
#21024
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
CD5
(Immune molecular markers)
Original: Tumor cells#were#CD45+/ CD3+/ CD4+/ CD8+/ CD56+/ Pan-Cytokeratin-/ CD20-/ CD79a-/ CD5-/ CD30-
#21023
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
CD79a
(Immune molecular markers)
Original: Tumor cells#were#CD45+/ CD3+/ CD4+/ CD8+/ CD56+/ Pan-Cytokeratin-/ CD20-/ CD79a-/ CD5-/ CD30-
#21022
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
CD20
(Immune molecular markers)
Original: Tumor cells#were#CD45+/ CD3+/ CD4+/ CD8+/ CD56+/ Pan-Cytokeratin-/ CD20-/ CD79a-/ CD5-/ CD30-
#21021
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
Pan-Cytokeratin
(Immune molecular markers)
Original: Tumor cells#were#CD45+/ CD3+/ CD4+/ CD8+/ CD56+/ Pan-Cytokeratin-/ CD20-/ CD79a-/ CD5-/ CD30-
#21020
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD56
(Immune molecular markers)
Original: Tumor cells#were#CD45+/ CD3+/ CD4+/ CD8+/ CD56+/ Pan-Cytokeratin-/ CD20-/ CD79a-/ CD5-/ CD30-
#21019
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD8
(Immune molecular markers)
Original: Tumor cells#were#CD45+/ CD3+/ CD4+/ CD8+/ CD56+/ Pan-Cytokeratin-/ CD20-/ CD79a-/ CD5-/ CD30-
#21018
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD4
(Immune molecular markers)
Original: Tumor cells#were#CD45+/ CD3+/ CD4+/ CD8+/ CD56+/ Pan-Cytokeratin-/ CD20-/ CD79a-/ CD5-/ CD30-
#21017
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD3
(Immune molecular markers)
Original: Tumor cells#were#CD45+/ CD3+/ CD4+/ CD8+/ CD56+/ Pan-Cytokeratin-/ CD20-/ CD79a-/ CD5-/ CD30-
#21016
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD45
(Immune molecular markers)
Original: Tumor cells#were#CD45+/ CD3+/ CD4+/ CD8+/ CD56+/ Pan-Cytokeratin-/ CD20-/ CD79a-/ CD5-/ CD30-
#21015
high Confidence
Subject:
Cells
(cell)
→
are_strongly_positive_for
→
Object:
leukocyte_common_antigen
(Diagnostic molecular markers)
Original: Cells#were strongly positive for#leukocyte common antigen
#21014
high Confidence
Subject:
PSA
(Protein markers)
→
shows_positivity_in
→
Object:
tumor_cells
(Tumor cells)
Original: Positivity for PSA#was demonstrated by#immunocytochemical stain in tumor cells
#21013
high Confidence
Subject:
cytokeratin_20
(Protein markers)
→
shows_positivity_in
→
Object:
prostate_cancer
(Tumor diseases)
Original: In 2 cases/ there#was#negative staining for PSA and cytokeratin 7/ and positivity for cytokeratin 20
#21012
high Confidence
Subject:
cytokeratin_7
(Protein markers)
→
shows_negative_stain_in
→
Object:
prostate_cancer
(Tumor diseases)
Original: In 2 cases/ there#was#negative staining for PSA and cytokeratin 7/ and positivity for cytokeratin 20
#21011
high Confidence
Subject:
PSA
(Protein markers)
→
shows_negative_stain_in
→
Object:
prostate_cancer
(Tumor diseases)
Original: In 2 cases/ there#was#negative staining for PSA and cytokeratin 7/ and positivity for cytokeratin 20
#21010
high Confidence
Subject:
racemase
(Enzymes)
→
shows_positivity_in
→
Object:
prostate_cancer
(Tumor diseases)
Original: Immunohistochemical results#further mimicked#prostate cancer with negative stains for basal cell markers and positive stains for racemase
#21009
high Confidence
Subject:
p63
(Protein markers)
→
shows_negative_stain_in
→
Object:
prostate_cancer
(Tumor diseases)
Original: Immunohistochemical results#further mimicked#prostate cancer with negative stains for basal cell markers and positive stains for racemase
#21008
high Confidence
Subject:
high-molecular_weight_cytokeratin
(Protein markers)
→
shows_negative_stain_in
→
Object:
prostate_cancer
(Tumor diseases)
Original: Immunohistochemical results#further mimicked#prostate cancer with negative stains for basal cell markers and positive stains for racemase
#21007
high Confidence
Subject:
S-100_protein
(Protein markers)
→
shows_positivity_in
→
Object:
malignant_melanoma_of_the_esophagus
(Tumor diseases)
Original: The immunohistochemical study#revealed#positivity for HMB-45 and S-100 protein
#21006
high Confidence
Subject:
HMB-45
(Protein markers)
→
shows_positivity_in
→
Object:
malignant_melanoma_of_the_esophagus
(Tumor diseases)
Original: The immunohistochemical study#revealed#positivity for HMB-45 and S-100 protein
#21005
high Confidence
Subject:
patient
(patient)
→
underwent
→
Object:
chemotherapy
(Treatment)
Original: Patient#underwent#radiation (50 Gray) and chemotherapy (cisplatin/ 5 courses)
#21004
high Confidence
Subject:
patient
(patient)
→
underwent
→
Object:
radiation_therapy
(Treatment)
Original: Patient#underwent#radiation (50 Gray) and chemotherapy (cisplatin/ 5 courses)
#21003
high Confidence
Subject:
CD56
(Cell adhesion molecules)
→
shows_positive_reaction
→
Object:
Immunohistochemistry
(Detection Methods)
Original: immunohistochemical study#revealed#positive reaction for KIT/ PDGFRA/ synaptophysin/ and CD56
#21002
high Confidence
Subject:
PDGFRA
(Receptor tyrosine kinases)
→
shows_positive_reaction
→
Object:
Immunohistochemistry
(Detection Methods)
Original: immunohistochemical study#revealed#positive reaction for KIT/ PDGFRA/ synaptophysin/ and CD56
#21001
high Confidence
Subject:
KIT
(Receptor tyrosine kinases)
→
shows_positive_reaction
→
Object:
Immunohistochemistry
(Detection Methods)
Original: immunohistochemical study#revealed#positive reaction for KIT/ PDGFRA/ synaptophysin/ and CD56
#21000
high Confidence
Subject:
adenocarcinoma in situ (AIS)
(Tumor type)
→
shows
→
Object:
moderate_to_coarse_granularity
(Cell morphology)
Original: adenocarcinoma in situ (AIS)#shows#nuclear enlargement/ oval nuclear shape/ hyperchromasia/ and moderate-to-coarse granularity
#20999
high Confidence
Subject:
adenocarcinoma in situ (AIS)
(Tumor type)
→
shows
→
Object:
hyperchromasia
(Cell morphology)
Original: adenocarcinoma in situ (AIS)#shows#nuclear enlargement/ oval nuclear shape/ hyperchromasia/ and moderate-to-coarse granularity
#20998
high Confidence
Subject:
adenocarcinoma in situ (AIS)
(Tumor type)
→
shows
→
Object:
oval_nuclear_shape
(Cell morphology)
Original: adenocarcinoma in situ (AIS)#shows#nuclear enlargement/ oval nuclear shape/ hyperchromasia/ and moderate-to-coarse granularity
#20997
high Confidence
Subject:
adenocarcinoma in situ (AIS)
(Tumor type)
→
shows
→
Object:
nuclear_enlargement
(Cell morphology)
Original: adenocarcinoma in situ (AIS)#shows#nuclear enlargement/ oval nuclear shape/ hyperchromasia/ and moderate-to-coarse granularity
#20996
high Confidence
Subject:
fine-needle_aspiration_biopsy
(Diagnostic techniques)
→
is_performed_on
→
Object:
adenoid_cystic_carcinoma_of_breast
(Tumor type)
Original: Fine-needle aspiration biopsy#is performed on#adenoid cystic carcinoma of the breast
#20995
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD79A
(B cell markers)
Original: tumor cells#are#positive for CD20 and CD79a
#20994
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD20
(B cell markers)
Original: tumor cells#are#positive for CD20 and CD79a
#20993
high Confidence
Subject:
endometrioid_adenocarcinoma
(Tumor type)
→
exhibits
→
Object:
no_lymph_node_metastasis
(Pathological characteristics)
Original: endometrioid adenocarcinomas#exhibit#superficial invasion of myometrium and no lymph node metastasis
#20992
high Confidence
Subject:
endometrioid_adenocarcinoma
(Tumor type)
→
exhibits
→
Object:
superficial_invasion_of_myometrium
(Pathological characteristics)
Original: endometrioid adenocarcinomas#exhibit#superficial invasion of myometrium and no lymph node metastasis
#20991
high Confidence
Subject:
tumor
(Tumor)
→
diagnosed_as
→
Object:
anaplastic_ependymoma
(Tumor type)
Original: tumor#was diagnosed as#anaplastic ependymoma
#20990
high Confidence
Subject:
abdominal_CT_scan
(Imaging tests)
→
demonstrates
→
Object:
left_adrenal_mass
(Tumor Entities)
Original: abdominal CT scan#demonstrates#a 5.3x4.8x3.7 cm homogenous left adrenal mass with distinct borders
#20989
high Confidence
Subject:
orbital_meningiomas
(Tumor type)
→
are_diagnosed_by
→
Object:
fine-needle_aspiration_cytology
(Diagnostic techniques)
Original: orbital meningiomas#are diagnosed by#fine-needle aspiration cytology (FNAC)
#20988
high Confidence
Subject:
meningiomas
(Tumor type)
→
are_derived_from
→
Object:
arachnoid_cells
(Cell Type)
Original: meningiomas#are derived from#arachnoid cells
#20987
high Confidence
Subject:
absence_of_basal_cells
(Histological characteristics)
→
confirms
→
Object:
diagnosis_of_cancer
(Disease diagnosis)
Original: absence of basal cells#confirms#the diagnosis of cancer
#20986
high Confidence
Subject:
background_intestinal_metaplasia
(Changes in tissue morphology)
→
is_present_in
→
Object:
Barrett_esophagus
(disease)
Original: Background intestinal metaplasia#was present in#Barrett esophagus
#20985
high Confidence
Subject:
malignant_cells
(Tumor cells)
→
express
→
Object:
CD123
(Protein markers)
Original: Malignant cells#express#bright CD45/ HLA-DR/ and CD33/ dim CD4/ heterogeneous CD56/ and partial CD123
#20984
high Confidence
Subject:
malignant_cells
(Tumor cells)
→
express
→
Object:
CD56
(Protein markers)
Original: Malignant cells#express#bright CD45/ HLA-DR/ and CD33/ dim CD4/ heterogeneous CD56/ and partial CD123
#20983
high Confidence
Subject:
malignant_cells
(Tumor cells)
→
express
→
Object:
CD4
(Protein markers)
Original: Malignant cells#express#bright CD45/ HLA-DR/ and CD33/ dim CD4/ heterogeneous CD56/ and partial CD123
#20982
high Confidence
Subject:
malignant_cells
(Tumor cells)
→
express
→
Object:
CD33
(Protein markers)
Original: Malignant cells#express#bright CD45/ HLA-DR/ and CD33/ dim CD4/ heterogeneous CD56/ and partial CD123
#20981
high Confidence
Subject:
malignant_cells
(Tumor cells)
→
express
→
Object:
HLA-DR
(Protein markers)
Original: Malignant cells#express#bright CD45/ HLA-DR/ and CD33/ dim CD4/ heterogeneous CD56/ and partial CD123
#20980
high Confidence
Subject:
malignant_cells
(Tumor cells)
→
express
→
Object:
CD45
(Protein markers)
Original: Malignant cells#express#bright CD45/ HLA-DR/ and CD33/ dim CD4/ heterogeneous CD56/ and partial CD123
#20979
high Confidence
Subject:
tumor
(Tumor tissue)
→
are_positive_for
→
Object:
FOSB
(Transcription Factors)
Original: Tumors#are positive for#nuclear and cytoplasmic FOSB
#20978
high Confidence
Subject:
gastric-type_adenocarcinoma
(Adenocarcinoma subtype)
→
is_subtype_of
→
Object:
uterine_cervix_adenocarcinoma
(Cervical adenocarcinoma)
Original: Gastric-type adenocarcinoma#is a subtype of#uterine cervix adenocarcinoma
#20977
high Confidence
Subject:
β-catenin
(Signal transduction proteins)
→
shows_nuclear_immunoreactivity_in
→
Object:
tumor_cells
(Tumor cells)
Original: Tumor cells#showed#diffuse immunoreactivity for glypican-3 and nuclear β-catenin
#20976
high Confidence
Subject:
glypican-3
(Hepatocellular carcinoma-related protein)
→
shows_diffuse_immunoreactivity_in
→
Object:
tumor_cells
(Tumor cells)
Original: Tumor cells#showed#diffuse immunoreactivity for glypican-3 and nuclear β-catenin
#20975
high Confidence
Subject:
IMTCGS
(Molecular detection indicators)
→
has
→
Object:
prognostic_significance
(Prognostic significance)
Original: IMTCGS#has#prognostic significance
#20974
high Confidence
Subject:
Medullary_thyroid_carcinoma
(Tumor type)
→
is
→
Object:
rare_neuroendocrine_thyroid_neoplasm
(Disease phenotype)
Original: Medullary thyroid carcinoma#is#a rare neuroendocrine thyroid neoplasm
#20973
high Confidence
Subject:
Immunohistochemistry
(Detection Technology)
→
detects
→
Object:
S-100_protein
(protein)
Original: immunohistochemistry#detected#vimentin/ S-100 protein/ and other markers
#20972
high Confidence
Subject:
Immunohistochemistry
(Detection Technology)
→
detects
→
Object:
vimentin
(protein)
Original: immunohistochemistry#detected#vimentin/ S-100 protein/ and other markers
#20971
high Confidence
Subject:
ependymoma
(Tumor type)
→
is_included_in
→
Object:
WHO_classification_of_nervous_system
(Disease classification criteria)
Original: clear cell ependymoma#was included in#WHO classification of nervous system
#20970
high Confidence
Subject:
renal_medullary_carcinoma
(Tumor diseases)
→
affects
→
Object:
young_African_American_males_with_sickle_cell_trait
(High-risk patient groups)
Original: renal medullary carcinoma#affects#young African American males with sickle cell trait
#20969
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
expresses
→
Object:
PROX-1
(Transcription Factors)
Original: neoplastic cells#express#vimentin/ factor VIII-related antigen/ and PROX-1
#20968
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
expresses
→
Object:
factor_VIII-related_antigen
(Vascular associated antigen)
Original: neoplastic cells#express#vimentin/ factor VIII-related antigen/ and PROX-1
#20967
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
expresses
→
Object:
vimentin
(Intermediate filament protein)
Original: neoplastic cells#express#vimentin/ factor VIII-related antigen/ and PROX-1
#20966
high Confidence
Subject:
prominent_nucleoli
(Nuclear characteristics)
→
is_characteristic_of
→
Object:
melanoma
(Tumor)
Original: melanoma#is characterized by#large pleomorphic cells with eosinophilic cytoplasm/ prominent nucleoli/ and S100 protein
#20965
high Confidence
Subject:
eosinophilic_cytoplasm
(Cytoplasmic characteristics)
→
is_characteristic_of
→
Object:
melanoma
(Tumor)
Original: melanoma#is characterized by#large pleomorphic cells with eosinophilic cytoplasm/ prominent nucleoli/ and S100 protein
#20964
high Confidence
Subject:
large_pleomorphic_cells
(Tumor cell subtype)
→
are_characteristic_of
→
Object:
melanoma
(Tumor)
Original: melanoma#is characterized by#large pleomorphic cells with eosinophilic cytoplasm/ prominent nucleoli/ and S100 protein
#20963
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
NSE
(Protein markers)
Original: Tumor cells#are positive for#synaptophysin/ GFAP/ CD117/ S100/ Cam5.2/ and NSE
#20962
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
Cam5.2
(Protein markers)
Original: Tumor cells#are positive for#synaptophysin/ GFAP/ CD117/ S100/ Cam5.2/ and NSE
#20961
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
S100
(Protein markers)
Original: Tumor cells#are positive for#synaptophysin/ GFAP/ CD117/ S100/ Cam5.2/ and NSE
#20960
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD117
(Protein markers)
Original: Tumor cells#are positive for#synaptophysin/ GFAP/ CD117/ S100/ Cam5.2/ and NSE
#20959
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
GFAP
(Protein markers)
Original: Tumor cells#are positive for#synaptophysin/ GFAP/ CD117/ S100/ Cam5.2/ and NSE
#20958
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
synaptophysin
(Protein markers)
Original: Tumor cells#are positive for#synaptophysin/ GFAP/ CD117/ S100/ Cam5.2/ and NSE
#20957
high Confidence
Subject:
diagnosis
(Diagnosis conclusion)
→
was_made_as
→
Object:
diffuse_medium_sized_non-Hodgkin's_lymphoma_B-cell_type
(Tumor type)
Original: A diagnosis#was made as#diffuse/ medium-sized non-Hodgkin's lymphoma/ B-cell type
#20956
high Confidence
Subject:
malignant_lymphoma
(Tumor type)
→
originates_in
→
Object:
bone
(organ)
Original: Malignant lymphoma#originates in#bone
#20955
high Confidence
Subject:
p53_protein
(Transcription Factors)
→
is_demonstrated_in
→
Object:
basaloid_squamous_cell_carcinoma
(Tumor type)
Original: p53 protein#was demonstrated#in basaloid squamous cell carcinoma
#20954
high Confidence
Subject:
basaloid_squamous_cell_carcinoma
(Tumor type)
→
is_characterized_as
→
Object:
variant_of_squamous_cell_carcinoma
(Tumor type)
Original: basaloid squamous cell carcinoma (BSCC)#is characterized as#a variant of squamous cell carcinoma
#20953
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
S100
(Calcium Binding Protein)
Original: tumor cells#were positive for#MITF and S-100
#20952
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
MITF
(Transcription Factors)
Original: tumor cells#were positive for#MITF and S-100
#20951
high Confidence
Subject:
malignant_melanoma
(Tumor phenotype)
→
diagnosed_by
→
Object:
immunohistochemical_examination
(Diagnostic techniques)
Original: malignant melanoma#was diagnosed#after immunohistochemical examination
#20950
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
show_strong_positive_staining_for
→
Object:
c-KIT
(Protein markers)
Original: Tumor cells#exhibit#strong positive staining for HMB-45 and c-KIT
#20949
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
show_strong_positive_staining_for
→
Object:
HMB-45
(Protein markers)
Original: Tumor cells#exhibit#strong positive staining for HMB-45 and c-KIT
#20948
high Confidence
Subject:
FDC
(Follicular dendritic cells)
→
highlighted_by
→
Object:
CD35
(Cell surface markers)
Original: FDC#highlighted by#CD21/ CD35/ R4/23/ Ki-M4/ CNA.42/ CD68
#20947
high Confidence
Subject:
FDC
(Follicular dendritic cells)
→
highlighted_by
→
Object:
CD21
(Cell surface markers)
Original: FDC#highlighted by#CD21/ CD35/ R4/23/ Ki-M4/ CNA.42/ CD68
#20946
high Confidence
Subject:
tumor
(Tumor tissue)
→
diagnosed_as
→
Object:
pituitary_carcinoma
(disease)
Original: Tumor#was diagnosed as#pituitary carcinoma from pars intermedia cells
#20945
high Confidence
Subject:
17_month_old_infant
(patient)
→
developed
→
Object:
acute_megakaryoblastic_leukemia
(disease)
Original: A 17-month-old infant#developed#acute megakaryoblastic leukemia
#20944
high Confidence
Subject:
Anaplastic_lymphoma_kinase
(Protein kinase)
→
is_used_as
→
Object:
diagnostic_marker
(Molecular markers)
Original: Anaplastic lymphoma kinase#is used as#a diagnostic marker
#20943
high Confidence
Subject:
S100B
(Protein coding genes)
→
shows_positive_staining_with
→
Object:
S-100
(protein)
Original: these cells#stained positively with#S-100
#20942
high Confidence
Subject:
NUT
(Protein coding genes)
→
forms_fusion_oncogene_with
→
Object:
BRD4
(Protein coding genes)
Original: The BRD4 gene#forms#a fusion oncogene BRD4-NUT through translocation
#20941
high Confidence
Subject:
BRD4
(Protein coding genes)
→
forms_fusion_oncogene_with
→
Object:
NUT
(Protein coding genes)
Original: The BRD4 gene#forms#a fusion oncogene BRD4-NUT through translocation
#20940
high Confidence
Subject:
immunocytochemical_stains
(Detection Technology)
→
revealed
→
Object:
cytokeratin_negativity
(Protein expression)
Original: Immunocytochemical stains#revealed#S-100 and vimentin positivity/ while actin/ myoglobin/ and cytokeratin stains were negative
#20939
high Confidence
Subject:
immunocytochemical_stains
(Detection Technology)
→
revealed
→
Object:
myoglobin_negativity
(Protein expression)
Original: Immunocytochemical stains#revealed#S-100 and vimentin positivity/ while actin/ myoglobin/ and cytokeratin stains were negative
#20938
high Confidence
Subject:
immunocytochemical_stains
(Detection Technology)
→
revealed
→
Object:
actin_negativity
(Protein expression)
Original: Immunocytochemical stains#revealed#S-100 and vimentin positivity/ while actin/ myoglobin/ and cytokeratin stains were negative
#20937
high Confidence
Subject:
immunocytochemical_stains
(Detection Technology)
→
revealed
→
Object:
vimentin_positivity
(Protein expression)
Original: Immunocytochemical stains#revealed#S-100 and vimentin positivity/ while actin/ myoglobin/ and cytokeratin stains were negative
#20936
high Confidence
Subject:
immunocytochemical_stains
(Detection Technology)
→
revealed
→
Object:
S-100_positivity
(Protein expression)
Original: Immunocytochemical stains#revealed#S-100 and vimentin positivity/ while actin/ myoglobin/ and cytokeratin stains were negative
#20935
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
showed
→
Object:
membranous_positivity_for_Ki-67
(Protein expression)
Original: Tumor cells#showed#distinctive membranous positivity for Ki-67
#20934
high Confidence
Subject:
malignant_tumors
(Tumor)
→
show
→
Object:
capsular_invasion
(Tumor invasion phenotype)
Original: malignant tumors#show#venous or capsular invasion or distant metastasis
#20933
high Confidence
Subject:
malignant_tumors
(Tumor)
→
show
→
Object:
venous_invasion
(Tumor invasion phenotype)
Original: malignant tumors#show#venous or capsular invasion or distant metastasis
#20932
high Confidence
Subject:
Cytopathologic_diagnosis_by_FNA
(Diagnostic techniques)
→
is_imperative_for
→
Object:
Primary_pancreatic_lymphomas
(Tumor diseases)
Original: Cytopathologic diagnosis by FNA#is imperative for#primary pancreatic lymphomas
#20931
high Confidence
Subject:
hyperlobation
(Nuclear structure)
→
is_consistent_with
→
Object:
papillary_thyroid_carcinoma
(disease)
Original: Neoplastic follicular cell nuclei#were divided into#grooves/ pseudoinclusions/ and hyperlobation consistent with papillary thyroid carcinoma
#20930
high Confidence
Subject:
pseudoinclusions
(Nuclear structure)
→
are_consistent_with
→
Object:
papillary_thyroid_carcinoma
(disease)
Original: Neoplastic follicular cell nuclei#were divided into#grooves/ pseudoinclusions/ and hyperlobation consistent with papillary thyroid carcinoma
#20929
high Confidence
Subject:
grooves
(Nuclear structure)
→
are_consistent_with
→
Object:
papillary_thyroid_carcinoma
(disease)
Original: Neoplastic follicular cell nuclei#were divided into#grooves/ pseudoinclusions/ and hyperlobation consistent with papillary thyroid carcinoma
#20928
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD34
(Diagnostic markers)
Original: tumor cells#are positive for#CD34
#20927
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD31
(Diagnostic markers)
Original: tumor cells#are positive for#CD31
#20926
high Confidence
Subject:
tumor_sample
(Tumor samples)
→
positive_for
→
Object:
CD34
(Molecular markers)
Original: Immunohistochemical markers#were positive for#Factor VIII antigen/ CD31/ and CD34
#20925
high Confidence
Subject:
tumor_sample
(Tumor samples)
→
positive_for
→
Object:
CD31
(Molecular markers)
Original: Immunohistochemical markers#were positive for#Factor VIII antigen/ CD31/ and CD34
#20924
high Confidence
Subject:
tumor_sample
(Tumor samples)
→
positive_for
→
Object:
Factor_VIII_antigen
(Molecular markers)
Original: Immunohistochemical markers#were positive for#Factor VIII antigen/ CD31/ and CD34
#20923
high Confidence
Subject:
immunocytochemical_method
(Immunoassay technology)
→
reveals
→
Object:
vimentin
(protein)
Original: Immunocytochemical methods#revealed#immunoreactivity for cytokeratin/ epithelial membrane antigen/ and vimentin
#20922
high Confidence
Subject:
immunocytochemical_method
(Immunoassay technology)
→
reveals
→
Object:
epithelial_membrane_antigen
(protein)
Original: Immunocytochemical methods#revealed#immunoreactivity for cytokeratin/ epithelial membrane antigen/ and vimentin
#20921
high Confidence
Subject:
immunocytochemical_method
(Immunoassay technology)
→
reveals
→
Object:
cytokeratin
(protein)
Original: Immunocytochemical methods#revealed#immunoreactivity for cytokeratin/ epithelial membrane antigen/ and vimentin
#20920
high Confidence
Subject:
pleomorphic_cells
(Tumor cells)
→
showed
→
Object:
black_pigments
(Cell morphology)
Original: infilating nests of pleomorphic cells#showed#prominent nucleoli and black pigments
#20919
high Confidence
Subject:
pleomorphic_cells
(Tumor cells)
→
showed
→
Object:
prominent_nucleoli
(Cell morphology)
Original: infilating nests of pleomorphic cells#showed#prominent nucleoli and black pigments
#20918
high Confidence
Subject:
rhabdoid_component
(Organizational structure)
→
shows
→
Object:
prominent_nucleoli
(Cell morphology)
Original: rhabdoid component#shows#abundant eosinophilic cytoplasm/ eccentric nuclei/ and prominent nucleoli
#20917
high Confidence
Subject:
rhabdoid_component
(Organizational structure)
→
shows
→
Object:
eccentric_nuclei
(Cell morphology)
Original: rhabdoid component#shows#abundant eosinophilic cytoplasm/ eccentric nuclei/ and prominent nucleoli
#20916
high Confidence
Subject:
rhabdoid_component
(Organizational structure)
→
shows
→
Object:
abundant_eosinophilic_cytoplasm
(Cell morphology)
Original: rhabdoid component#shows#abundant eosinophilic cytoplasm/ eccentric nuclei/ and prominent nucleoli
#20915
high Confidence
Subject:
avidin-biotin-complex_immunoperoxidase_method
(Immunohistochemistry)
→
is_used_for
→
Object:
staining
(dyeing)
Original: avidin-biotin-complex immunoperoxidase method#is used for#staining
#20914
high Confidence
Subject:
anticyclin_monoclonal_antibody
(Monoclonal antibodies)
→
is_used_to
→
Object:
survey_cyclin_expression_in_cytologic_preparations
(Protein expression detection)
Original: anticyclin monoclonal antibody#is used to#survey cyclin expression in cytologic preparations
#20913
high Confidence
Subject:
EMA
(Epithelial membrane antigen)
→
shows
→
Object:
immunohistochemistry_positivity
(Immunohistochemistry results)
Original: pan-cytokeratin AE1/AE3 and EMA#show#positivity in immunohistochemistry
#20912
high Confidence
Subject:
pan-cytokeratin_AE1/AE3
(Cytoskeletal proteins)
→
shows
→
Object:
immunohistochemistry_positivity
(Immunohistochemistry results)
Original: pan-cytokeratin AE1/AE3 and EMA#show#positivity in immunohistochemistry
#20911
high Confidence
Subject:
anaplastic_lymphoma_kinase
(Protein kinase)
→
overexpression_helps_distinguish
→
Object:
IMT
(Tumor)
Original: overexpression of anaplastic lymphoma kinase#helps distinguish#IMT from malignant mimics
#20910
high Confidence
Subject:
Acinar-cell_carcinoma
(Acinar cell carcinoma)
→
was_confirmed_by
→
Object:
ultrastructural_study
(Ultrastructural examination)
Original: Acinar-cell carcinoma#was confirmed by#histological and ultrastructural studies
#20909
high Confidence
Subject:
Acinar-cell_carcinoma
(Acinar cell carcinoma)
→
was_confirmed_by
→
Object:
histological_study
(Histological examination)
Original: Acinar-cell carcinoma#was confirmed by#histological and ultrastructural studies
#20908
high Confidence
Subject:
Basal_cell_layer
(Basal cell layer)
→
is_intact_in
→
Object:
benign_hyperplasias
(Benign hyperplasia)
Original: Basal cell layer (BCL)#is intact in#benign hyperplasias
#20907
high Confidence
Subject:
MYCN amplification
(Gene amplification)
→
promotes
→
Object:
karyorrhectic activity
(Cellular Processes)
Original: MYCN amplification#promotes#mitotic and karyorrhectic activities
#20906
high Confidence
Subject:
MYCN amplification
(Gene amplification)
→
promotes
→
Object:
Mitotic activity
(Cellular Processes)
Original: MYCN amplification#promotes#mitotic and karyorrhectic activities
#20905
high Confidence
Subject:
MYCN amplification
(Gene amplification)
→
inhibits
→
Object:
cellular differentiation
(Cell differentiation)
Original: MYCN amplification#prevents#cellular differentiation
#20904
high Confidence
Subject:
Alpha-actin
(α-Actin)
→
used_for
→
Object:
tumor characterization
(Tumor phenotype determination)
Original: Cytokeratin/ vimentin/ S-100/ melan-A/ vWF/ desmin/ actin/ and alpha-actin#were applied for#tumor characterization
#20903
high Confidence
Subject:
Actin
(Actin)
→
used_for
→
Object:
tumor characterization
(Tumor phenotype determination)
Original: Cytokeratin/ vimentin/ S-100/ melan-A/ vWF/ desmin/ actin/ and alpha-actin#were applied for#tumor characterization
#20902
high Confidence
Subject:
Desmin
(Desmin)
→
used_for
→
Object:
tumor characterization
(Tumor phenotype determination)
Original: Cytokeratin/ vimentin/ S-100/ melan-A/ vWF/ desmin/ actin/ and alpha-actin#were applied for#tumor characterization
#20901
high Confidence
Subject:
wxya
(Von Willebrand Factor)
→
used_for
→
Object:
tumor characterization
(Tumor phenotype determination)
Original: Cytokeratin/ vimentin/ S-100/ melan-A/ vWF/ desmin/ actin/ and alpha-actin#were applied for#tumor characterization
#20900
high Confidence
Subject:
Melan-A
(Melan-A protein)
→
used_for
→
Object:
tumor characterization
(Tumor phenotype determination)
Original: Cytokeratin/ vimentin/ S-100/ melan-A/ vWF/ desmin/ actin/ and alpha-actin#were applied for#tumor characterization
#20899
high Confidence
Subject:
S-100
(S-100 protein)
→
used_for
→
Object:
tumor characterization
(Tumor phenotype determination)
Original: Cytokeratin/ vimentin/ S-100/ melan-A/ vWF/ desmin/ actin/ and alpha-actin#were applied for#tumor characterization
#20898
high Confidence
Subject:
Vimentin
(Vimentin)
→
used_for
→
Object:
tumor characterization
(Tumor phenotype determination)
Original: Cytokeratin/ vimentin/ S-100/ melan-A/ vWF/ desmin/ actin/ and alpha-actin#were applied for#tumor characterization
#20897
high Confidence
Subject:
Cytokeratin
(Cytokeratin)
→
used_for
→
Object:
tumor characterization
(Tumor phenotype determination)
Original: Cytokeratin/ vimentin/ S-100/ melan-A/ vWF/ desmin/ actin/ and alpha-actin#were applied for#tumor characterization
#20896
high Confidence
Subject:
initial_pathological_diagnosis
(Diagnosis conclusion)
→
was
→
Object:
benign_pleomorphic_adenoma
(Benign tumors)
Original: Initial pathological diagnosis#was#benign pleomorphic adenoma
#20895
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
stain_positive_for
→
Object:
Melan-A
(Protein markers)
Original: Tumor cells#stain positive for#Mic-2 (CD-99 antigen)/ vimentin/ synaptophysin/ and Melan-A
#20894
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
stain_positive_for
→
Object:
synaptophysin
(Protein markers)
Original: Tumor cells#stain positive for#Mic-2 (CD-99 antigen)/ vimentin/ synaptophysin/ and Melan-A
#20893
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
stain_positive_for
→
Object:
vimentin
(Protein markers)
Original: Tumor cells#stain positive for#Mic-2 (CD-99 antigen)/ vimentin/ synaptophysin/ and Melan-A
#20892
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
stain_positive_for
→
Object:
Mic-2_(CD-99_antigen)
(Protein markers)
Original: Tumor cells#stain positive for#Mic-2 (CD-99 antigen)/ vimentin/ synaptophysin/ and Melan-A
#20891
high Confidence
Subject:
neoplasm
(Tumor cells)
→
exhibits
→
Object:
granular_eosinophilic_cytoplasm
(Cytoplasmic characteristics)
Original: Neoplasms#exhibit#solid or acinar growth pattern/ dense neoplastic cellularity/ uniform nuclei with prominent nucleoli/ and granular eosinophilic cytoplasm
#20890
high Confidence
Subject:
neoplasm
(Tumor cells)
→
exhibits
→
Object:
uniform_nuclei_with_prominent_nucleoli
(Nuclear characteristics)
Original: Neoplasms#exhibit#solid or acinar growth pattern/ dense neoplastic cellularity/ uniform nuclei with prominent nucleoli/ and granular eosinophilic cytoplasm
#20889
high Confidence
Subject:
neoplasm
(Tumor cells)
→
exhibits
→
Object:
dense_neoplastic_cellularity
(Cell density characteristics)
Original: Neoplasms#exhibit#solid or acinar growth pattern/ dense neoplastic cellularity/ uniform nuclei with prominent nucleoli/ and granular eosinophilic cytoplasm
#20888
high Confidence
Subject:
neoplasm
(Tumor cells)
→
exhibits
→
Object:
acinar_growth_pattern
(Histological characteristics)
Original: Neoplasms#exhibit#solid or acinar growth pattern/ dense neoplastic cellularity/ uniform nuclei with prominent nucleoli/ and granular eosinophilic cytoplasm
#20887
high Confidence
Subject:
neoplasm
(Tumor cells)
→
exhibits
→
Object:
solid_growth_pattern
(Histological characteristics)
Original: Neoplasms#exhibit#solid or acinar growth pattern/ dense neoplastic cellularity/ uniform nuclei with prominent nucleoli/ and granular eosinophilic cytoplasm
#20886
high Confidence
Subject:
papillary_appearance
(Morphological characteristics)
→
is_shown_by
→
Object:
CK7
(Structural proteins)
Original: Papillary appearance#is shown by#CK7
#20885
high Confidence
Subject:
Immunoreaction
(Immune response)
→
performed_with
→
Object:
monoclonal_antibody_to_CK20
(Antibody)
Original: Immunoreactions#are performed with#monoclonal antibodies to CK7 and CK20
#20884
high Confidence
Subject:
Immunoreaction
(Immune response)
→
performed_with
→
Object:
monoclonal_antibody_to_CK7
(Antibody)
Original: Immunoreactions#are performed with#monoclonal antibodies to CK7 and CK20
#20883
high Confidence
Subject:
nucleus_of_PTC_in_Graves_disease
(Cell structure)
→
shows
→
Object:
small_eccentric_nucleoli
(Nuclear characteristics)
Original: The nuclei of PTC in GD#show#prominent nuclear elongation/ pale powdery chromatin/ intranuclear grooves/ and small eccentric nucleoli
#20882
high Confidence
Subject:
nucleus_of_PTC_in_Graves_disease
(Cell structure)
→
shows
→
Object:
intranuclear_grooves
(Nuclear characteristics)
Original: The nuclei of PTC in GD#show#prominent nuclear elongation/ pale powdery chromatin/ intranuclear grooves/ and small eccentric nucleoli
#20881
high Confidence
Subject:
nucleus_of_PTC_in_Graves_disease
(Cell structure)
→
shows
→
Object:
pale_powdery_chromatin
(Chromatin characteristics)
Original: The nuclei of PTC in GD#show#prominent nuclear elongation/ pale powdery chromatin/ intranuclear grooves/ and small eccentric nucleoli
#20880
high Confidence
Subject:
nucleus_of_PTC_in_Graves_disease
(Cell structure)
→
shows
→
Object:
prominent_nuclear_elongation
(Nuclear characteristics)
Original: The nuclei of PTC in GD#show#prominent nuclear elongation/ pale powdery chromatin/ intranuclear grooves/ and small eccentric nucleoli
#20879
high Confidence
Subject:
cell_cytoplasm
(Cell structure)
→
shows
→
Object:
lightly_eosinophilic_scant_cytoplasm
(Cytoplasmic characteristics)
Original: The cells#have#oval nuclei with prominent nucleoli and lightly eosinophilic scant cytoplasm
#20878
high Confidence
Subject:
cell_nucleus
(Cell structure)
→
has
→
Object:
prominent_nucleoli
(Nuclear characteristics)
Original: The cells#have#oval nuclei with prominent nucleoli and lightly eosinophilic scant cytoplasm
#20877
high Confidence
Subject:
cell_nucleus
(Cell structure)
→
has
→
Object:
oval_shape
(Morphological characteristics)
Original: The cells#have#oval nuclei with prominent nucleoli and lightly eosinophilic scant cytoplasm
#20876
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
composed_of
→
Object:
intestinal-type_adenocarcinoma
(Tumor type)
Original: Second tumor#was composed of#LCNEC and intestinal-type adenocarcinoma
#20875
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
composed_of
→
Object:
LCNEC
(Tumor type)
Original: Second tumor#was composed of#LCNEC and intestinal-type adenocarcinoma
#20874
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
consisted_entirely_of
→
Object:
LCNEC
(Tumor type)
Original: One tumor#consisted entirely of#LCNEC
#20873
high Confidence
Subject:
Tumor
(Tumor)
→
diagnosed_as
→
Object:
ovarian_dysgerminoma
(Disease Type)
Original: Tumor#was diagnosed as#an ovarian dysgerminoma in a medaka
#20872
high Confidence
Subject:
cystic_sebaceous_adenoma
(Tumor)
→
is_marker_for
→
Object:
Muir-Torre_syndrome
(disease)
Original: Cystic sebaceous adenoma#has been reported as#a specific marker for Muir-Torre syndrome (MTS)
#20871
high Confidence
Subject:
malignant_cytology
(Cytological diagnosis)
→
confirmed_by
→
Object:
lung_cancer_histology
(Histological diagnosis)
Original: malignant cytology#confirmed#lung cancer histologically
#20870
high Confidence
Subject:
rhabdoid_cells
(Tumor cells)
→
are_characterized_by
→
Object:
eosinophilic_inclusions
(Cytoplasmic inclusion bodies)
Original: rhabdoid cells#are characterized by#eccentric vesicular nuclei/ prominent nucleoli/ and eosinophilic inclusions
#20869
high Confidence
Subject:
rhabdoid_cells
(Tumor cells)
→
are_characterized_by
→
Object:
prominent_nucleoli
(Nuclear characteristics)
Original: rhabdoid cells#are characterized by#eccentric vesicular nuclei/ prominent nucleoli/ and eosinophilic inclusions
#20868
high Confidence
Subject:
rhabdoid_cells
(Tumor cells)
→
are_characterized_by
→
Object:
eccentric_vesicular_nuclei
(Nuclear characteristics)
Original: rhabdoid cells#are characterized by#eccentric vesicular nuclei/ prominent nucleoli/ and eosinophilic inclusions
#20867
high Confidence
Subject:
apocrine_carcinoma
(Tumor type)
→
is_characterized_by
→
Object:
prominent_nucleoli
(Nuclear characteristics)
Original: apocrine carcinoma#is characterized by#large atypical cells with eosinophilic cytoplasm/ large nuclei/ and prominent nucleoli
#20866
high Confidence
Subject:
apocrine_carcinoma
(Tumor type)
→
is_characterized_by
→
Object:
large_nuclei
(Nuclear characteristics)
Original: apocrine carcinoma#is characterized by#large atypical cells with eosinophilic cytoplasm/ large nuclei/ and prominent nucleoli
#20865
high Confidence
Subject:
apocrine_carcinoma
(Tumor type)
→
is_characterized_by
→
Object:
eosinophilic_cytoplasm
(Cell morphology)
Original: apocrine carcinoma#is characterized by#large atypical cells with eosinophilic cytoplasm/ large nuclei/ and prominent nucleoli
#20864
high Confidence
Subject:
apocrine_carcinoma
(Tumor type)
→
is_characterized_by
→
Object:
large_atypical_cells
(Cell morphology)
Original: apocrine carcinoma#is characterized by#large atypical cells with eosinophilic cytoplasm/ large nuclei/ and prominent nucleoli
#20863
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
form
→
Object:
glandular_tubular_structures
(Glandular structure)
Original: tumor cells#form#glandular-tubular structures
#20862
high Confidence
Subject:
Rhabdoid meningioma
(Tumor diseases)
→
differential_diagnosis_involves
→
Object:
atypical teratoid/rhabdoid tumor
(Tumor diseases)
Original: Rhabdoid meningioma#differential diagnosis involves#metastatic adenocarcinoma/ melanoma/ and atypical teratoid/rhabdoid tumor
#20861
high Confidence
Subject:
Rhabdoid meningioma
(Tumor diseases)
→
differential_diagnosis_involves
→
Object:
melanoma
(Tumor diseases)
Original: Rhabdoid meningioma#differential diagnosis involves#metastatic adenocarcinoma/ melanoma/ and atypical teratoid/rhabdoid tumor
#20860
high Confidence
Subject:
Rhabdoid meningioma
(Tumor diseases)
→
differential_diagnosis_involves
→
Object:
metastatic adenocarcinoma
(Tumor diseases)
Original: Rhabdoid meningioma#differential diagnosis involves#metastatic adenocarcinoma/ melanoma/ and atypical teratoid/rhabdoid tumor
#20859
high Confidence
Subject:
Rhabdoid meningioma
(Tumor diseases)
→
is_described_as
→
Object:
WHO Grade III
(Disease classification)
Original: Rhabdoid meningioma#is described as#rare/ WHO Grade III/ aggressive tumor with recurrence risk
#20858
high Confidence
Subject:
Rhabdoid meningioma
(Tumor diseases)
→
is_described_as
→
Object:
rare tumor
(Disease phenotype)
Original: Rhabdoid meningioma#is described as#rare/ WHO Grade III/ aggressive tumor with recurrence risk
#20857
high Confidence
Subject:
Extrarenal rhabdoid tumor
(Tumor diseases)
→
is_diagnosed_based_on
→
Object:
cytoplasmic intermediate filaments in epithelioid cells
(Cell morphological characteristics)
Original: Extrarenal rhabdoid tumor#is diagnosed based on#proliferation of epithelioid cells with large nuclei/ prominent nucleoli/ and cytoplasmic intermediate filaments
#20856
high Confidence
Subject:
Extrarenal rhabdoid tumor
(Tumor diseases)
→
is_diagnosed_based_on
→
Object:
prominent nucleoli in epithelioid cells
(Cell morphological characteristics)
Original: Extrarenal rhabdoid tumor#is diagnosed based on#proliferation of epithelioid cells with large nuclei/ prominent nucleoli/ and cytoplasmic intermediate filaments
#20855
high Confidence
Subject:
Extrarenal rhabdoid tumor
(Tumor diseases)
→
is_diagnosed_based_on
→
Object:
proliferation of epithelioid cells with large nuclei
(Cell morphological characteristics)
Original: Extrarenal rhabdoid tumor#is diagnosed based on#proliferation of epithelioid cells with large nuclei/ prominent nucleoli/ and cytoplasmic intermediate filaments
#20854
high Confidence
Subject:
Surveillance
(Medical monitoring behavior)
→
should_be_started_from
→
Object:
early_age
(Timing of diagnosis)
Original: Surveillance of renal tumor in FH gene germline mutation-positive patients#should be started from#early age using ultrasound sonography or magnetic resonance imaging
#20853
high Confidence
Subject:
granular_cell_tumors
(Tumor type)
→
are_divided_into
→
Object:
malignant_category
(Tumor grade)
Original: granular cell tumors#are divided into#benign/ atypical/ and malignant categories
#20852
high Confidence
Subject:
granular_cell_tumors
(Tumor type)
→
are_divided_into
→
Object:
atypical_category
(Tumor grade)
Original: granular cell tumors#are divided into#benign/ atypical/ and malignant categories
#20851
high Confidence
Subject:
granular_cell_tumors
(Tumor type)
→
are_divided_into
→
Object:
benign_category
(Tumor grade)
Original: granular cell tumors#are divided into#benign/ atypical/ and malignant categories
#20850
high Confidence
Subject:
accurate_diagnosis
(Diagnostic behavior)
→
is_required_for
→
Object:
soft_tissue_tumors_with_poor_prognosis
(Tumor type)
Original: accurate diagnosis#is required for#soft tissue tumors with poor prognosis
#20849
high Confidence
Subject:
breast_carcinoma_cases
(Cancer patients)
→
are_categorized_into
→
Object:
basal_like
(Molecular subtypes)
Original: breast carcinoma cases#are categorized into#luminal A/ luminal B/ null subtypes/ HER2-overexpressing and basal-like
#20848
high Confidence
Subject:
breast_carcinoma_cases
(Cancer patients)
→
are_categorized_into
→
Object:
HER2_overexpressing
(Molecular subtypes)
Original: breast carcinoma cases#are categorized into#luminal A/ luminal B/ null subtypes/ HER2-overexpressing and basal-like
#20847
high Confidence
Subject:
breast_carcinoma_cases
(Cancer patients)
→
are_categorized_into
→
Object:
luminal_B
(Molecular subtypes)
Original: breast carcinoma cases#are categorized into#luminal A/ luminal B/ null subtypes/ HER2-overexpressing and basal-like
#20846
high Confidence
Subject:
breast_carcinoma_cases
(Cancer patients)
→
are_categorized_into
→
Object:
luminal_A
(Molecular subtypes)
Original: breast carcinoma cases#are categorized into#luminal A/ luminal B/ null subtypes/ HER2-overexpressing and basal-like
#20845
high Confidence
Subject:
computed_tomography
(Imaging methods)
→
revealed
→
Object:
pulmonary_mass
(Tumor type)
Original: Computed tomography#revealed#a pulmonary mass with vacuolar tumor cells and abundant eosinophilic cytoplasm
#20844
high Confidence
Subject:
immunohistochemical_staining
(Molecular detection methods)
→
detects
→
Object:
FH_deficiency
(Protein deficiency)
Original: Immunohistochemical staining#was performed on#300 uSMTs to detect FH deficiency
#20843
high Confidence
Subject:
immunohistochemical_staining
(Molecular detection methods)
→
was_performed_on
→
Object:
uSMTs
(Tumor type)
Original: Immunohistochemical staining#was performed on#300 uSMTs to detect FH deficiency
#20842
high Confidence
Subject:
tumor
(Tumor)
→
was_positive_for
→
Object:
vimentin
(Protein markers)
Original: tumor#was positive for#neuroendocrine markers and vimentin
#20841
high Confidence
Subject:
tumor
(Tumor)
→
was_positive_for
→
Object:
neuroendocrine_markers
(Protein markers)
Original: tumor#was positive for#neuroendocrine markers and vimentin
#20840
high Confidence
Subject:
Rhabdoid_cells
(Tumor cell type)
→
are_confirmed_by
→
Object:
electron_microscopic_studies
(Detection Technology)
Original: Rhabdoid cells#are confirmed by#immunohistochemical and electron microscopic studies
#20839
high Confidence
Subject:
Rhabdoid_cells
(Tumor cell type)
→
are_confirmed_by
→
Object:
immunohistochemical_studies
(Detection Technology)
Original: Rhabdoid cells#are confirmed by#immunohistochemical and electron microscopic studies
#20838
high Confidence
Subject:
NUT_protein_expression
(Protein expression)
→
is_detected_by
→
Object:
immunohistochemistry_with_C52B1
(Detection Technology)
Original: NUT protein expression#is detected by#immunohistochemistry using rabbit monoclonal antibody C52B1
#20837
high Confidence
Subject:
calretinin
(Calcium Binding Protein)
→
shows_expression_in
→
Object:
granular_cell_tumor
(Tumor type)
Original: Granular cell tumor#shows expression of#CD56/ CD68/ S-100 protein/ inhibin/ and calretinin
#20836
high Confidence
Subject:
inhibin
(Glycoprotein hormones)
→
shows_expression_in
→
Object:
granular_cell_tumor
(Tumor type)
Original: Granular cell tumor#shows expression of#CD56/ CD68/ S-100 protein/ inhibin/ and calretinin
#20835
high Confidence
Subject:
S-100_protein
(Calcium Binding Protein)
→
shows_expression_in
→
Object:
granular_cell_tumor
(Tumor type)
Original: Granular cell tumor#shows expression of#CD56/ CD68/ S-100 protein/ inhibin/ and calretinin
#20834
high Confidence
Subject:
CD68
(Lysosome-associated proteins)
→
shows_expression_in
→
Object:
granular_cell_tumor
(Tumor type)
Original: Granular cell tumor#shows expression of#CD56/ CD68/ S-100 protein/ inhibin/ and calretinin
#20833
high Confidence
Subject:
CD56
(Cell membrane glycoprotein)
→
shows_expression_in
→
Object:
granular_cell_tumor
(Tumor type)
Original: Granular cell tumor#shows expression of#CD56/ CD68/ S-100 protein/ inhibin/ and calretinin
#20832
high Confidence
Subject:
Immunohistochemistry
(Diagnostic techniques)
→
shows
→
Object:
vimentin_positive_cytoplasmic_staining
(Protein expression)
Original: Immunohistochemistry#showed#positive cytoplasmic staining for cytokeratin and vimentin
#20831
high Confidence
Subject:
Immunohistochemistry
(Diagnostic techniques)
→
shows
→
Object:
cytokeratin_positive_cytoplasmic_staining
(Protein expression)
Original: Immunohistochemistry#showed#positive cytoplasmic staining for cytokeratin and vimentin
#20830
high Confidence
Subject:
immunohistochemical_staining_with_MoAb_Ki-67
(Immunohistochemistry)
→
evaluates
→
Object:
proliferative_activity_of_brain_tumors
(Tumor proliferation activity)
Original: immunohistochemical staining with MoAb Ki-67#can evaluate#proliferative activity of brain tumors
#20829
high Confidence
Subject:
adipophilin
(Protein markers)
→
detected_in
→
Object:
cases
(Case)
Original: Expression of epithelial membrane antigen/ perilipin and adipophilin#were detected#in all cases
#20828
high Confidence
Subject:
perilipin
(Protein markers)
→
detected_in
→
Object:
cases
(Case)
Original: Expression of epithelial membrane antigen/ perilipin and adipophilin#were detected#in all cases
#20827
high Confidence
Subject:
epithelial_membrane_antigen
(Protein markers)
→
detected_in
→
Object:
cases
(Case)
Original: Expression of epithelial membrane antigen/ perilipin and adipophilin#were detected#in all cases
#20826
high Confidence
Subject:
Cytodiagnostic_criteria
(Diagnostic criteria)
→
distinguish
→
Object:
thyroid_neoplasms
(disease)
Original: Cytodiagnostic criteria#distinguish#Hashimoto's thyroiditis from thyroid neoplasms
#20825
high Confidence
Subject:
Cytodiagnostic_criteria
(Diagnostic criteria)
→
distinguish
→
Object:
Hashimoto's_thyroiditis
(disease)
Original: Cytodiagnostic criteria#distinguish#Hashimoto's thyroiditis from thyroid neoplasms
#20824
high Confidence
Subject:
histopathologic_diagnoses
(Pathological diagnosis)
→
are_grouped_as
→
Object:
malignant
(Malignant)
Original: Histopathologic diagnoses#are grouped as#benign/ follicular neoplasm/ and malignant
#20823
high Confidence
Subject:
histopathologic_diagnoses
(Pathological diagnosis)
→
are_grouped_as
→
Object:
follicular_neoplasm
(Follicular tumor)
Original: Histopathologic diagnoses#are grouped as#benign/ follicular neoplasm/ and malignant
#20822
high Confidence
Subject:
histopathologic_diagnoses
(Pathological diagnosis)
→
are_grouped_as
→
Object:
benign
(benign)
Original: Histopathologic diagnoses#are grouped as#benign/ follicular neoplasm/ and malignant
#20821
high Confidence
Subject:
thyroid_FNA_cytology_samples
(Fine needle aspiration cytology specimen)
→
are_examined_for
→
Object:
preoperative_evaluation_of_thyroid_nodules
(Preoperative evaluation)
Original: thyroid FNA cytology samples#are examined for#preoperative evaluation of thyroid nodules
#20820
high Confidence
Subject:
HER2+_neoplasms
(Tumor subtype)
→
demonstrate
→
Object:
centered_macronucleoli
(Cell morphology)
Original: HER2+ neoplasms#demonstrate#centered macronucleoli
#20819
high Confidence
Subject:
cytology_smears
(Cytology samples)
→
are_scored_for
→
Object:
morphological_features
(Cell morphology)
Original: cytology smears#are scored for#morphological features
#20818
high Confidence
Subject:
Vesiculobullous_lesions
(Pathological phenotype)
→
consistent_with
→
Object:
Pemphigus_vulgaris
(disease)
Original: Cervical biopsy#revealed#vesiculobullous lesions consistent with PV
#20817
high Confidence
Subject:
Antibodies
(Antibody)
→
target
→
Object:
epithelial_cell_surface_glycoproteins
(Epithelial cell surface glycoprotein)
Original: Pemphigus vulgaris (PV)#is caused by#abnormal production of antibodies against epithelial cell surface glycoproteins
#20816
high Confidence
Subject:
Pemphigus_vulgaris
(disease)
→
is_caused_by
→
Object:
abnormal_production_of_antibodies
(Abnormal antibody production)
Original: Pemphigus vulgaris (PV)#is caused by#abnormal production of antibodies against epithelial cell surface glycoproteins
#20815
high Confidence
Subject:
fine_needle_aspiration_biopsy
(Pathological diagnosis technology)
→
diagnoses
→
Object:
proliferative_myositis
(disease)
Original: Proliferative myositis (PM)#is diagnosed by#fine needle aspiration biopsy (FNAB)
#20814
high Confidence
Subject:
expert_pathologists
(Clinical Experts)
→
support
→
Object:
benign_endometrial_polyp_diagnosis
(Clinical diagnosis)
Original: Expert pathologists#support#benign endometrial polyp diagnosis
#20813
high Confidence
Subject:
ALTCL
(Tumor subtype)
→
is_a_subtype_of
→
Object:
non-Hodgkin_T-cell_lymphoma
(Tumor type)
Original: ALTCL#is a subtype of#non-Hodgkin T-cell lymphoma
#20812
high Confidence
Subject:
BBC
(Cytological testing methods)
→
is_sensitive_for
→
Object:
detecting_cholangiocarcinoma
(Diagnostic Process)
Original: BBC#is sensitive for#detecting cholangiocarcinoma in PSC patients
#20811
high Confidence
Subject:
NONO-TFE3_RCC
(Tumor subtype)
→
is_a_subtype_of
→
Object:
Xp11.2_translocation_renal_cell_carcinoma
(Tumor subtype)
Original: NONO-TFE3 RCC#is a subtype of#Xp11.2 translocation renal cell carcinoma
#20810
high Confidence
Subject:
PRNRP
(Tumor subtype)
→
is_a_subtype_of
→
Object:
papillary_renal_cell_carcinoma
(Tumor type)
Original: PRNRP#is a subtype of#papillary renal cell carcinoma with characteristic morphological/ immunophenotypic/ and molecular features
#20809
high Confidence
Subject:
morphologic_features_of_neoplastic_cells
(Cell morphology)
→
are_consistent_with
→
Object:
astrocytic_neoplasm
(Tumor)
Original: Morphologic features of neoplastic cells#were consistent with#astrocytic neoplasm
#20808
high Confidence
Subject:
unusual_RCC
(Disease classification)
→
shows
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: unusual RCC#shows#rhabdoid morphology and poor prognosis
#20807
high Confidence
Subject:
unusual_RCC
(Disease classification)
→
shows
→
Object:
rhabdoid_morphology
(Cell morphology)
Original: unusual RCC#shows#rhabdoid morphology and poor prognosis
#20806
high Confidence
Subject:
BRG1
(Chromatin remodeling proteins)
→
expression_is_absent_in
→
Object:
unusual_RCC
(Disease classification)
Original: INI1 and BRG1 expression#are absent in#unusual RCC
#20805
high Confidence
Subject:
INI1
(Chromatin remodeling proteins)
→
expression_is_absent_in
→
Object:
unusual_RCC
(Disease classification)
Original: INI1 and BRG1 expression#are absent in#unusual RCC
#20804
high Confidence
Subject:
malignant cells
(Tumor cells)
→
are_positive_for
→
Object:
prostatic-specific antigen
(Tumor markers)
Original: malignant cells#were positive for#prostatic-specific antigen
#20803
high Confidence
Subject:
malignant cells
(Tumor cells)
→
are_consistent_with
→
Object:
prostatic adenocarcinoma
(Malignant tumors)
Original: cytologic preparations#revealed#cells consistent with prostatic adenocarcinoma
#20802
high Confidence
Subject:
Prominent_nucleoli
(Nucleolar characteristics)
→
had
→
Object:
practical_significance_in_pathologic_diagnosis
(Significance of pathological diagnosis)
Original: Prominent nucleoli#had#practical significance in pathologic diagnosis
#20801
high Confidence
Subject:
Prostatic_needle_biopsy
(Histological samples)
→
included
→
Object:
adenocarcinoma_case
(Adenocarcinoma Cases)
Original: 250 cases of prostatic needle biopsy#included#100 cases of adenocarcinoma
#20800
high Confidence
Subject:
AP-LCIS
(Breast epithelial lesions)
→
is_associated_with
→
Object:
invasive_lobular_carcinoma
(Invasive lobular carcinoma)
Original: AP-LCIS#is associated with#invasive lobular carcinoma
#20799
high Confidence
Subject:
atypical_lymphoid_cells
(Abnormal lymphocytes)
→
are_identified_as
→
Object:
T-cell_nature
(Cell type characteristics)
Original: atypical lymphoid cells#are identified as#t-cell nature
#20798
high Confidence
Subject:
sentinel_lymph_node
(Lymph nodes)
→
was_effaced_by
→
Object:
metastatic_melanoma
(Tumor)
Original: sentinel lymph node#was effaced by#metastatic melanoma
#20797
high Confidence
Subject:
immunosuppressive_drug
(Immunosuppressive drugs)
→
causes
→
Object:
increased_de_novo_malignancy_risk
(Disease Risk)
Original: immunosuppressive drugs#have been identified as#the primary culprit for increased risk of de novo malignancy in liver transplant recipients
#20796
high Confidence
Subject:
FNA_smear
(Cytology)
→
combined_with
→
Object:
HMCK_immunohistochemistry
(Immunohistochemistry)
Original: FNA smears#together with#HMCK immunohistochemistry can be useful for the cytologic differential diagnosis of renal tumors
#20795
high Confidence
Subject:
acute_myeloid_leukemia_patient
(Acute myeloid leukemia patients)
→
is_classified_as
→
Object:
LMA-M0
(Acute Myeloid Leukemia Subtypes)
Original: Eight patients with acute myeloid leukemia#were classified as#LMA-MO
#20794
high Confidence
Subject:
fibroadenoma
(Fibroadenoma)
→
is_a
→
Object:
benign_breast_neoplasm
(Benign breast tumors)
Original: Fibroadenoma#is a#benign neoplasm of the breast and ectopic breast tissue
#20793
high Confidence
Subject:
Meningiomas
(Meningioma)
→
are_classified_as
→
Object:
malignant_meningioma
(Malignant meningioma)
Original: 120 meningiomas#are classified as#101 benign/ 15 atypical/ and 4 malignant meningiomas
#20792
high Confidence
Subject:
Meningiomas
(Meningioma)
→
are_classified_as
→
Object:
atypical_meningioma
(Atypical meningioma)
Original: 120 meningiomas#are classified as#101 benign/ 15 atypical/ and 4 malignant meningiomas
#20791
high Confidence
Subject:
Meningiomas
(Meningioma)
→
are_classified_as
→
Object:
benign_meningioma
(Benign meningioma)
Original: 120 meningiomas#are classified as#101 benign/ 15 atypical/ and 4 malignant meningiomas
#20790
high Confidence
Subject:
Primary_lesion_of_bulbar_conjunctiva
(Lesions)
→
is_classified_as
→
Object:
Stage_IB_acquired_melanosis
(Stage IB Acquired Melanosis)
Original: Primary lesion of bulbar conjunctiva#is classified as#Stage IB acquired melanosis
#20789
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
show_positive_expression_for
→
Object:
CK8/18
(Cell markers)
Original: tumor cells#showed positive expression for#CK7/ CD117/ EMA/ vimentin/ and CK8/18
#20788
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
show_positive_expression_for
→
Object:
vimentin
(Cytoskeletal proteins)
Original: tumor cells#showed positive expression for#CK7/ CD117/ EMA/ vimentin/ and CK8/18
#20787
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
show_positive_expression_for
→
Object:
EMA
(Cell markers)
Original: tumor cells#showed positive expression for#CK7/ CD117/ EMA/ vimentin/ and CK8/18
#20786
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
show_positive_expression_for
→
Object:
CD117
(Cell markers)
Original: tumor cells#showed positive expression for#CK7/ CD117/ EMA/ vimentin/ and CK8/18
#20785
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
show_positive_expression_for
→
Object:
CK7
(Cell markers)
Original: tumor cells#showed positive expression for#CK7/ CD117/ EMA/ vimentin/ and CK8/18
#20784
high Confidence
Subject:
enlarged_nucleoli
(Nuclear components)
→
were
→
Object:
reliable_indicators_of_endometrial_cancer
(Diagnostic value)
Original: Enlarged nuclei and nucleoli in endometrial cells#were#reliable indicators of endometrial cancer
#20783
high Confidence
Subject:
enlarged_nuclei
(Nuclear components)
→
were
→
Object:
reliable_indicators_of_endometrial_cancer
(Diagnostic value)
Original: Enlarged nuclei and nucleoli in endometrial cells#were#reliable indicators of endometrial cancer
#20782
high Confidence
Subject:
KRAS_mutation
(Gene mutation)
→
is_identified_in
→
Object:
lymph_node_fine-needle_aspiration_specimen
(Clinical sample type)
Original: Advanced pulmonary adenocarcinoma harboring KRAS mutation#is identified in#lymph node fine-needle aspiration specimens
#20781
high Confidence
Subject:
clear_cell_papillary_renal_cell_carcinoma
(Tumor type)
→
shows
→
Object:
calcium_oxalate_crystal_deposition
(Tissue composition characteristics)
Original: Histology of clear cell papillary renal cell carcinoma#is distinctive for#sieve-like architecture/ eosinophilic cytoplasm/ large nuclei with prominent nucleoli/ and calcium oxalate crystal deposition
#20780
high Confidence
Subject:
clear_cell_papillary_renal_cell_carcinoma
(Tumor type)
→
shows
→
Object:
prominent_nucleolus
(Cell morphology)
Original: Histology of clear cell papillary renal cell carcinoma#is distinctive for#sieve-like architecture/ eosinophilic cytoplasm/ large nuclei with prominent nucleoli/ and calcium oxalate crystal deposition
#20779
high Confidence
Subject:
clear_cell_papillary_renal_cell_carcinoma
(Tumor type)
→
shows
→
Object:
large_nucleus
(Cell morphology)
Original: Histology of clear cell papillary renal cell carcinoma#is distinctive for#sieve-like architecture/ eosinophilic cytoplasm/ large nuclei with prominent nucleoli/ and calcium oxalate crystal deposition
#20778
high Confidence
Subject:
clear_cell_papillary_renal_cell_carcinoma
(Tumor type)
→
shows
→
Object:
eosinophilic_cytoplasm
(Cell morphology)
Original: Histology of clear cell papillary renal cell carcinoma#is distinctive for#sieve-like architecture/ eosinophilic cytoplasm/ large nuclei with prominent nucleoli/ and calcium oxalate crystal deposition
#20777
high Confidence
Subject:
clear_cell_papillary_renal_cell_carcinoma
(Tumor type)
→
shows
→
Object:
sieve-like_architecture
(Tissue morphology)
Original: Histology of clear cell papillary renal cell carcinoma#is distinctive for#sieve-like architecture/ eosinophilic cytoplasm/ large nuclei with prominent nucleoli/ and calcium oxalate crystal deposition
#20776
high Confidence
Subject:
melanoma
(Malignant tumors)
→
shows
→
Object:
dermal_naevocytic_differentiation
(Cell differentiation characteristics)
Original: Histopathological criteria to distinguish naevi from melanoma#include#lack of pagetoid lateral spread/ absence of mitotic activity in deep dermal component/ and dermal naevocytic differentiation
#20775
high Confidence
Subject:
melanoma
(Malignant tumors)
→
shows
→
Object:
absence_of_mitotic_activity_in_deep_dermal_component
(Tissue morphology)
Original: Histopathological criteria to distinguish naevi from melanoma#include#lack of pagetoid lateral spread/ absence of mitotic activity in deep dermal component/ and dermal naevocytic differentiation
#20774
high Confidence
Subject:
melanoma
(Malignant tumors)
→
shows
→
Object:
lack_of_pagetoid_lateral_spread
(Tissue morphology)
Original: Histopathological criteria to distinguish naevi from melanoma#include#lack of pagetoid lateral spread/ absence of mitotic activity in deep dermal component/ and dermal naevocytic differentiation
#20773
high Confidence
Subject:
acral-lentiginous_naevus
(Benign pigmented nevus)
→
shows
→
Object:
prominent_nucleolus
(Cell morphology)
Original: Acral-lentiginous naevi#are distinguished by#elongation of rete ridges/ melanocyte proliferation/ and hyperchromatic nuclei with prominent nucleoli
#20772
high Confidence
Subject:
acral-lentiginous_naevus
(Benign pigmented nevus)
→
shows
→
Object:
hyperchromatic_nucleus
(Cell morphology)
Original: Acral-lentiginous naevi#are distinguished by#elongation of rete ridges/ melanocyte proliferation/ and hyperchromatic nuclei with prominent nucleoli
#20771
high Confidence
Subject:
acral-lentiginous_naevus
(Benign pigmented nevus)
→
shows
→
Object:
melanocyte_proliferation
(Cell proliferation characteristics)
Original: Acral-lentiginous naevi#are distinguished by#elongation of rete ridges/ melanocyte proliferation/ and hyperchromatic nuclei with prominent nucleoli
#20770
high Confidence
Subject:
acral-lentiginous_naevus
(Benign pigmented nevus)
→
shows
→
Object:
elongation_of_rete_ridges
(Tissue morphology)
Original: Acral-lentiginous naevi#are distinguished by#elongation of rete ridges/ melanocyte proliferation/ and hyperchromatic nuclei with prominent nucleoli
#20769
high Confidence
Subject:
acral-lentiginous_naevus
(Benign pigmented nevus)
→
is_classified_as
→
Object:
special_entity
(Histological entity)
Original: Acral-lentiginous naevus#is classified as#a special entity distinct from other acral naevi
#20768
high Confidence
Subject:
classic_medulloblastoma
(Tumor type)
→
shows
→
Object:
fine_chromatin
(Cell morphology)
Original: Cytologic features of classic medulloblastoma#include#small cells with rounded/ uniform nuclei with fine chromatin
#20767
high Confidence
Subject:
classic_medulloblastoma
(Tumor type)
→
shows
→
Object:
uniform_nucleus
(Cell morphology)
Original: Cytologic features of classic medulloblastoma#include#small cells with rounded/ uniform nuclei with fine chromatin
#20766
high Confidence
Subject:
classic_medulloblastoma
(Tumor type)
→
shows
→
Object:
rounded_nucleus
(Cell morphology)
Original: Cytologic features of classic medulloblastoma#include#small cells with rounded/ uniform nuclei with fine chromatin
#20765
high Confidence
Subject:
classic_medulloblastoma
(Tumor type)
→
shows
→
Object:
small_cell
(Cell morphology)
Original: Cytologic features of classic medulloblastoma#include#small cells with rounded/ uniform nuclei with fine chromatin
#20764
high Confidence
Subject:
malignant_cell
(Tumor cells)
→
shows
→
Object:
visible_nucleolus
(Cell morphology)
Original: Malignant cells#had#high nucleocytoplasmic ratios/ highly pleomorphic and frequently polylobated nuclei with coarse chromatin and 1-3 visible nucleoli
#20763
high Confidence
Subject:
malignant_cell
(Tumor cells)
→
shows
→
Object:
coarse_chromatin
(Cell morphology)
Original: Malignant cells#had#high nucleocytoplasmic ratios/ highly pleomorphic and frequently polylobated nuclei with coarse chromatin and 1-3 visible nucleoli
#20762
high Confidence
Subject:
malignant_cell
(Tumor cells)
→
shows
→
Object:
polylobated_nucleus
(Cell morphology)
Original: Malignant cells#had#high nucleocytoplasmic ratios/ highly pleomorphic and frequently polylobated nuclei with coarse chromatin and 1-3 visible nucleoli
#20761
high Confidence
Subject:
malignant_cell
(Tumor cells)
→
shows
→
Object:
pleomorphic_nucleus
(Cell morphology)
Original: Malignant cells#had#high nucleocytoplasmic ratios/ highly pleomorphic and frequently polylobated nuclei with coarse chromatin and 1-3 visible nucleoli
#20760
high Confidence
Subject:
malignant_cell
(Tumor cells)
→
shows
→
Object:
high_nucleocytoplasmic_ratio
(Cell morphology)
Original: Malignant cells#had#high nucleocytoplasmic ratios/ highly pleomorphic and frequently polylobated nuclei with coarse chromatin and 1-3 visible nucleoli
#20759
high Confidence
Subject:
Microcystic_carcinoma
(Tumor)
→
is_classified_as
→
Object:
variant_of_conventional_acinar_adenocarcinoma
(Tumor subtype)
Original: Atrophic carcinoma and microcystic carcinoma#are classified as#variants of conventional acinar adenocarcinoma
#20758
high Confidence
Subject:
Atrophic_carcinoma
(Tumor)
→
is_classified_as
→
Object:
variant_of_conventional_acinar_adenocarcinoma
(Tumor subtype)
Original: Atrophic carcinoma and microcystic carcinoma#are classified as#variants of conventional acinar adenocarcinoma
#20757
high Confidence
Subject:
Sebaceous_carcinoma
(Tumor type)
→
metastasizes_to
→
Object:
regional_lymph_nodes
(organize)
Original: Sebaceous carcinoma#metastasizes to#regionallymph nodes
#20756
high Confidence
Subject:
Merkel_cell_carcinoma
(Tumor type)
→
metastasizes_to
→
Object:
pancreas
(organ)
Original: Merkel cell carcinoma (MCC)#metastasized to#pancreas
#20755
high Confidence
Subject:
SSC_tumor
(Tumor diseases)
→
carries
→
Object:
ETV6-NTRK3_translocation
(Gene fusion)
Original: SSC tumors#carry#classic ETV6-NTRK3 translocation
#20754
high Confidence
Subject:
epidermal_invasion
(Histological characteristics)
→
indicates
→
Object:
malignant_melanoma
(Malignant tumors)
Original: malignant melanoma#is diagnosed by#melanocytic cells with atypical nuclei/ prominent nucleoli/ mitoses/ and epidermal invasion
#20753
high Confidence
Subject:
Mitoses
(Cellular Processes)
→
indicates
→
Object:
malignant_melanoma
(Malignant tumors)
Original: malignant melanoma#is diagnosed by#melanocytic cells with atypical nuclei/ prominent nucleoli/ mitoses/ and epidermal invasion
#20752
high Confidence
Subject:
prominent_nucleoli
(Cell morphology)
→
indicates
→
Object:
malignant_melanoma
(Malignant tumors)
Original: malignant melanoma#is diagnosed by#melanocytic cells with atypical nuclei/ prominent nucleoli/ mitoses/ and epidermal invasion
#20751
high Confidence
Subject:
atypical_nuclei
(Cell morphology)
→
indicates
→
Object:
malignant_melanoma
(Malignant tumors)
Original: malignant melanoma#is diagnosed by#melanocytic cells with atypical nuclei/ prominent nucleoli/ mitoses/ and epidermal invasion
#20750
high Confidence
Subject:
melanocytic_cells
(Cell Type)
→
diagnoses
→
Object:
malignant_melanoma
(Malignant tumors)
Original: malignant melanoma#is diagnosed by#melanocytic cells with atypical nuclei/ prominent nucleoli/ mitoses/ and epidermal invasion
#20749
high Confidence
Subject:
Anaplastic_large_cell_Ki-1_lymphoma
(Lymphoma subtypes)
→
is_a_subtype_of
→
Object:
non-Hodgkin's_lymphoma
(Types of Lymphoma)
Original: Anaplastic large cell Ki-1 lymphomas#are#a subtype of non-Hodgkin's lymphoma
#20748
high Confidence
Subject:
SDH-deficient_RCC
(Kidney Cancer Subtypes)
→
arises_mostly_in
→
Object:
individuals_with_germline_mutations_of_SDHb
(Genetically susceptible people)
Original: SDH-deficient RCC#arises mostly in#individuals with germline mutations of SDHB
#20747
high Confidence
Subject:
adenoma_of_the_eccrine_glands
(Benign tumors)
→
is_diagnosed_based_on
→
Object:
histological_and_immunohistochemical_findings
(Diagnosis)
Original: adenoma of the eccrine glands#was diagnosed#based on histological and immunohistochemical findings
#20746
high Confidence
Subject:
tumors
(Tumor tissue)
→
are_reported_as
→
Object:
malignant
(Tumor phenotype)
Original: tumors#are reported as#malignant in most cases
#20745
high Confidence
Subject:
SMARCB1-deficient_tumors
(Tumor tissue)
→
includes
→
Object:
malignant_rhabdoid_tumor
(Tumor tissue)
Original: SMARCB1-deficient tumors#include#epithelioid sarcomas and malignant rhabdoid tumors
#20744
high Confidence
Subject:
SMARCB1-deficient_tumors
(Tumor tissue)
→
includes
→
Object:
epithelioid_sarcoma
(Tumor tissue)
Original: SMARCB1-deficient tumors#include#epithelioid sarcomas and malignant rhabdoid tumors
#20743
high Confidence
Subject:
BCL2
(Anti-apoptotic proteins)
→
correlates_with
→
Object:
clinicopathological_findings
(Clinicopathological characteristics)
Original: Ki-67 and bcl-2 expression#correlates with#clinicopathological findings
#20742
high Confidence
Subject:
KI67
(Cell proliferation markers)
→
correlates_with
→
Object:
clinicopathological_findings
(Clinicopathological characteristics)
Original: Ki-67 and bcl-2 expression#correlates with#clinicopathological findings
#20741
high Confidence
Subject:
ultrastructural_examination
(Diagnostic techniques)
→
provides
→
Object:
diagnosis_of_myofibrosarcoma
(Diagnosis conclusion)
Original: Ultrastructural examination#provides#the most confident diagnosis of myofibrosarcoma
#20740
high Confidence
Subject:
spindle_cells
(Spindle cells)
→
are_observed_in
→
Object:
pulmonary_blastoma
(Tumor type)
Original: pulmonary blastoma#should be considered when#small spindle-shaped cells are observed
#20739
high Confidence
Subject:
FNAC
(Cytological detection technology)
→
allows
→
Object:
medical_carcinoma_to_be_considered_in_diagnosis
(Possibility of diagnosis)
Original: FNAC#allows#medullary carcinoma to be considered in diagnosis
#20738
high Confidence
Subject:
sub-typing_system
(Diagnostic Tools)
→
is_suitable_for
→
Object:
predicting_postoperative_outcome_in_stage_I_lung_adenocarcinoma
(Clinical Outcomes)
Original: sub-typing system#is suitable for#predicting postoperative outcome in stage I lung adenocarcinoma
#20737
high Confidence
Subject:
NUT_midline_carcinoma
(Tumor)
→
confirmed_by
→
Object:
fluorescence_in_situ_hybridization
(Molecular diagnostic technology)
Original: NUT midline carcinoma#confirmed by#cytogenetic and fluorescence in situ hybridization studies
#20736
high Confidence
Subject:
NUT_midline_carcinoma
(Tumor)
→
confirmed_by
→
Object:
cytogenetic_study
(Molecular diagnostic technology)
Original: NUT midline carcinoma#confirmed by#cytogenetic and fluorescence in situ hybridization studies
#20735
high Confidence
Subject:
application_of_immunohistochemistry_markers
(Immunohistochemistry)
→
contributes_to
→
Object:
correct_diagnosis
(Diagnostic outcome)
Original: Correct diagnosis#can be achieved with#a combination of awareness of the lesion/ familiarity with characteristic cytologic features/ and application of appropriate immunohistochemistry markers
#20734
high Confidence
Subject:
endometrial_cells
(Glandular epithelial cells)
→
diagnoses
→
Object:
adenocarcinoma
(Disease phenotype)
Original: cytology and immunohistochemistry findings#revealed#8 cases suspicious of adenocarcinoma in situ (AIS)/adenocarcinoma in cervical liquid-based cytology
#20733
high Confidence
Subject:
large_lymphoid_cells
(Lymphocytes)
→
express
→
Object:
LCA
(Protein markers)
Original: gingival biopsy#showed#massive infiltration by large lymphoid cells expressing CD79a/ CD138/ cytoplasmic lambda light chain/ and LCA
#20732
high Confidence
Subject:
large_lymphoid_cells
(Lymphocytes)
→
express
→
Object:
cytoplasmic_lambda_light_chain
(Protein markers)
Original: gingival biopsy#showed#massive infiltration by large lymphoid cells expressing CD79a/ CD138/ cytoplasmic lambda light chain/ and LCA
#20731
high Confidence
Subject:
large_lymphoid_cells
(Lymphocytes)
→
express
→
Object:
CD138
(Protein markers)
Original: gingival biopsy#showed#massive infiltration by large lymphoid cells expressing CD79a/ CD138/ cytoplasmic lambda light chain/ and LCA
#20730
high Confidence
Subject:
large_lymphoid_cells
(Lymphocytes)
→
express
→
Object:
CD79a
(Protein markers)
Original: gingival biopsy#showed#massive infiltration by large lymphoid cells expressing CD79a/ CD138/ cytoplasmic lambda light chain/ and LCA
#20729
high Confidence
Subject:
trypsin
(Enzymes)
→
stains_positive_in
→
Object:
tumor_cells
(Tumor cells)
Original: Tumor cells#stain positive for#BCL10 and trypsin
#20728
high Confidence
Subject:
BCL10
(protein)
→
stains_positive_in
→
Object:
tumor_cells
(Tumor cells)
Original: Tumor cells#stain positive for#BCL10 and trypsin
#20727
high Confidence
Subject:
BCL10
(protein)
→
is_biomarker_for
→
Object:
pancreatic_acinar_cell_carcinoma
(Neoplastic diseases)
Original: BCL10#is#biomarker for pancreatic acinar cell carcinoma
#20726
high Confidence
Subject:
BRAF_V600E_mutation
(Gene mutation)
→
is_reported_in
→
Object:
histiocytic_sarcoma
(Disease phenotype)
Original: BRAF (V600E) mutation#is reported in#histiocytic sarcoma
#20725
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
HMB-45
(Melanin-related antibodies)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20724
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
S100_protein
(Cytoskeletal proteins)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20723
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
CD31
(Cell surface molecules)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20722
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
CD34
(Cell surface molecules)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20721
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
Chromogranin
(Secretory granule protein)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20720
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
epithelial_membrane_antigen
(Membrane Protein)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20719
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
carcinoembryonic_antigen
(Tumor markers)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20718
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
cytokeratins
(Cytoskeletal proteins)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20717
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
CD117
(Receptor protein)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20716
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
myogenin
(Transcription Factors)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20715
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
myoglobin
(Cytoskeletal proteins)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20714
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
muscle-specific_actin
(Cytoskeletal proteins)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20713
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
were_negative_for
→
Object:
smooth_muscle_actin
(Cytoskeletal proteins)
Original: neoplastic cells#were negative for#smooth muscle actin/ muscle-specific actin/ myoglobin/ myogenin/ CD117/ cytokeratins/ carcinoembryonic antigen/ epithelial membrane antigen/ chromogranin/ CD34/ CD31/ S100 protein/ HMB-45
#20712
high Confidence
Subject:
patient
(patient)
→
underwent
→
Object:
sentinel_lymph_node_biopsy
(Type of surgery)
Original: Patient#underwent#simple mastectomy and sentinel lymph node biopsy
#20711
high Confidence
Subject:
patient
(patient)
→
underwent
→
Object:
simple_mastectomy
(Type of surgery)
Original: Patient#underwent#simple mastectomy and sentinel lymph node biopsy
#20710
high Confidence
Subject:
tumor
(Tumor)
→
diagnosed_as
→
Object:
AcCC_of_the_breast
(Tumor type)
Original: Tumor#diagnosed as#AcCC of the breast
#20709
high Confidence
Subject:
MIB1
(Cell proliferation markers)
→
helps_to_differentiate_from
→
Object:
high-grade_primary_squamous_cell_carcinoma_of_thyroid
(Tumor type)
Original: Intermediate proliferation index (MIB-1 labeling index is usually less than 20%)#helps to differentiate it from#high-grade primary squamous cell carcinoma of the thyroid
#20708
high Confidence
Subject:
CD5
(Cell surface antigens)
→
is_key_feature_to_differentiate_from
→
Object:
high-grade_squamous_cell_carcinoma
(Tumor type)
Original: Positive immunoreactivity for CD5#is a key feature to differentiate it from#undifferentiated carcinoma/ poorly differentiated carcinoma/ medullary carcinoma/ and high-grade squamous cell carcinoma
#20707
high Confidence
Subject:
CD5
(Cell surface antigens)
→
is_key_feature_to_differentiate_from
→
Object:
medullary_carcinoma
(Tumor type)
Original: Positive immunoreactivity for CD5#is a key feature to differentiate it from#undifferentiated carcinoma/ poorly differentiated carcinoma/ medullary carcinoma/ and high-grade squamous cell carcinoma
#20706
high Confidence
Subject:
CD5
(Cell surface antigens)
→
is_key_feature_to_differentiate_from
→
Object:
poorly_differentiated_carcinoma
(Tumor type)
Original: Positive immunoreactivity for CD5#is a key feature to differentiate it from#undifferentiated carcinoma/ poorly differentiated carcinoma/ medullary carcinoma/ and high-grade squamous cell carcinoma
#20705
high Confidence
Subject:
CD5
(Cell surface antigens)
→
is_key_feature_to_differentiate_from
→
Object:
undifferentiated_carcinoma
(Tumor type)
Original: Positive immunoreactivity for CD5#is a key feature to differentiate it from#undifferentiated carcinoma/ poorly differentiated carcinoma/ medullary carcinoma/ and high-grade squamous cell carcinoma
#20704
high Confidence
Subject:
cell_of_origin
(Cell Type)
→
enables
→
Object:
accurate_classification_of_thyroid_lesions
(Diagnostic Process)
Original: Cell of origin#enables#accurate classification of thyroid lesions
#20703
high Confidence
Subject:
neoplastic_nuclei
(Nucleus)
→
reacted_with
→
Object:
FLI1
(Transcription Factors)
Original: Neoplastic nuclei#reacted with#Fli-1
#20702
high Confidence
Subject:
neoplastic_cell_membranes
(Cell membrane)
→
reacted_with
→
Object:
CD99
(Cell surface proteins)
Original: Neoplastic cell membranes#reacted with#CD99 (MIC2)
#20701
high Confidence
Subject:
fine_needle_aspiration_biopsy
(Diagnostic techniques)
→
is_valuable_for
→
Object:
preoperative_diagnosis_of_benign_tumor
(Diagnosis conclusion)
Original: Fine-needle aspiration biopsy#is valuable for#establishing the preoperative diagnosis of benign tumor
#20700
high Confidence
Subject:
malignant_fibrous_histiocytoma
(Tumor)
→
is_diagnosed_by
→
Object:
electron_microscopy
(Diagnostic Methods)
Original: Malignant fibrous histiocytoma#is diagnosed by#cytological analysis/ histopathologic analysis/ immunohistochemical staining/ and electron microscopy
#20699
high Confidence
Subject:
malignant_fibrous_histiocytoma
(Tumor)
→
is_diagnosed_by
→
Object:
immunohistochemical_staining
(Diagnostic Methods)
Original: Malignant fibrous histiocytoma#is diagnosed by#cytological analysis/ histopathologic analysis/ immunohistochemical staining/ and electron microscopy
#20698
high Confidence
Subject:
malignant_fibrous_histiocytoma
(Tumor)
→
is_diagnosed_by
→
Object:
histopathologic_analysis
(Diagnostic Methods)
Original: Malignant fibrous histiocytoma#is diagnosed by#cytological analysis/ histopathologic analysis/ immunohistochemical staining/ and electron microscopy
#20697
high Confidence
Subject:
malignant_fibrous_histiocytoma
(Tumor)
→
is_diagnosed_by
→
Object:
cytological_analysis
(Diagnostic Methods)
Original: Malignant fibrous histiocytoma#is diagnosed by#cytological analysis/ histopathologic analysis/ immunohistochemical staining/ and electron microscopy
#20696
high Confidence
Subject:
congenital_malignant_extrarenal_rhabdoid_tumor
(Tumor)
→
has
→
Object:
disseminated_metastases
(Metastatic phenotype)
Original: congenital malignant extrarenal rhabdoid tumor#has#disseminated metastases
#20695
high Confidence
Subject:
Fine-needle_aspiration_cytologic_diagnosis
(Diagnostic techniques)
→
is_supported_by
→
Object:
fine_structural_correlation
(Ultrastructural evidence)
Original: Fine-needle aspiration cytologic diagnosis#is supported by#clinicopathologic and fine structural correlations
#20694
high Confidence
Subject:
Fine-needle_aspiration_cytologic_diagnosis
(Diagnostic techniques)
→
is_supported_by
→
Object:
clinicopathologic_correlation
(Clinical pathological evidence)
Original: Fine-needle aspiration cytologic diagnosis#is supported by#clinicopathologic and fine structural correlations
#20693
high Confidence
Subject:
Patients
(patient)
→
underwent
→
Object:
axillary_sentinel_node_biopsy
(Tissue biopsy)
Original: Patients#underwent#breast conserving surgery and axillary sentinel node biopsy
#20692
high Confidence
Subject:
Patients
(patient)
→
underwent
→
Object:
breast_conserving_surgery
(Surgery)
Original: Patients#underwent#breast conserving surgery and axillary sentinel node biopsy
#20691
high Confidence
Subject:
34_year_old_man
(Patient characteristics)
→
diagnosed_with
→
Object:
clear_cell_carcinoma
(Tumor type)
Original: 34-year-old man#was diagnosed with#clear-cell carcinoma
#20690
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expresses
→
Object:
brachyury
(Transcription Factors)
Original: tumor cells#expressed#cytokeratin/ epithelial membrane antigen/ brachyury
#20689
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expresses
→
Object:
epithelial_membrane_antigen
(Cell membrane antigen)
Original: tumor cells#expressed#cytokeratin/ epithelial membrane antigen/ brachyury
#20688
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expresses
→
Object:
cytokeratin
(Cytoskeletal proteins)
Original: tumor cells#expressed#cytokeratin/ epithelial membrane antigen/ brachyury
#20687
high Confidence
Subject:
INI1
(Tumor suppressor proteins)
→
shows_loss_in
→
Object:
pediatric_poorly_differentiated_chordoma
(Tumor type)
Original: pediatric poorly differentiated chordoma cases#showed#INI1 loss
#20686
high Confidence
Subject:
tumors
(Tumor diseases)
→
were_negative_for
→
Object:
keratin
(Cytoskeletal proteins)
Original: Tumors#were negative for#keratin
#20685
high Confidence
Subject:
tumors
(Tumor diseases)
→
were_positive_for
→
Object:
GFAP
(glial fibrillary acid protein)
Original: Tumors#were positive for#CD99/ desmin/ myogenin/ MyoD1/ S100/ Sox10/ CD34/ GFAP
#20684
high Confidence
Subject:
tumors
(Tumor diseases)
→
were_positive_for
→
Object:
CD34
(Cell surface proteins)
Original: Tumors#were positive for#CD99/ desmin/ myogenin/ MyoD1/ S100/ Sox10/ CD34/ GFAP
#20683
high Confidence
Subject:
tumors
(Tumor diseases)
→
were_positive_for
→
Object:
Sox10
(Transcription Factors)
Original: Tumors#were positive for#CD99/ desmin/ myogenin/ MyoD1/ S100/ Sox10/ CD34/ GFAP
#20682
high Confidence
Subject:
tumors
(Tumor diseases)
→
were_positive_for
→
Object:
S100
(Calcium Binding Protein)
Original: Tumors#were positive for#CD99/ desmin/ myogenin/ MyoD1/ S100/ Sox10/ CD34/ GFAP
#20681
high Confidence
Subject:
tumors
(Tumor diseases)
→
were_positive_for
→
Object:
MyoD1
(Transcription Factors)
Original: Tumors#were positive for#CD99/ desmin/ myogenin/ MyoD1/ S100/ Sox10/ CD34/ GFAP
#20680
high Confidence
Subject:
tumors
(Tumor diseases)
→
were_positive_for
→
Object:
myogenin
(Transcription Factors)
Original: Tumors#were positive for#CD99/ desmin/ myogenin/ MyoD1/ S100/ Sox10/ CD34/ GFAP
#20679
high Confidence
Subject:
tumors
(Tumor diseases)
→
were_positive_for
→
Object:
desmin
(Cytoskeletal proteins)
Original: Tumors#were positive for#CD99/ desmin/ myogenin/ MyoD1/ S100/ Sox10/ CD34/ GFAP
#20678
high Confidence
Subject:
tumors
(Tumor diseases)
→
were_positive_for
→
Object:
CD99
(Cell surface proteins)
Original: Tumors#were positive for#CD99/ desmin/ myogenin/ MyoD1/ S100/ Sox10/ CD34/ GFAP
#20677
high Confidence
Subject:
cytotoxic_granules
(Cytotoxic granules)
→
are_present_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: Neoplastic cells#exhibit#cytoplasmic CD3+/ CD56+/ and cytotoxic granules
#20676
high Confidence
Subject:
CD56
(NK cell marker protein)
→
is_upregulated_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: Neoplastic cells#exhibit#cytoplasmic CD3+/ CD56+/ and cytotoxic granules
#20675
high Confidence
Subject:
CD3
(T cell marker protein)
→
is_upregulated_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: Neoplastic cells#exhibit#cytoplasmic CD3+/ CD56+/ and cytotoxic granules
#20674
high Confidence
Subject:
Malignant_rhabdoid_tumor
(Tumor diseases)
→
is_defined_by
→
Object:
histologic_phenotype
(Pathological phenotype)
Original: Malignant rhabdoid tumor#is defined by#its histologic phenotype
#20673
high Confidence
Subject:
Oncocytoma-like_AML
(Tumor diseases)
→
is
→
Object:
rare_renal_neoplasm
(Tumor diseases)
Original: Oncocytoma-like AML#is#a rare renal neoplasm
#20672
high Confidence
Subject:
oncocytoma-like_AML
(Rare tumors)
→
is
→
Object:
rare_entity
(Rare disease features)
Original: Oncocytoma-like AML#is#a rare entity
#20671
high Confidence
Subject:
somatic_type_malignancy
(Tumor)
→
arose_in
→
Object:
germ_cell_tumor
(Tumor)
Original: Somatic type malignancy#arose in#germ cell tumor
#20670
high Confidence
Subject:
Malignant_rhabdoid_tumor
(Tumor type)
→
possesses
→
Object:
prominent_nucleoli
(Cell morphology)
Original: Malignant rhabdoid tumor#possesses#cells with prominent nucleoli
#20669
high Confidence
Subject:
tumor_features
(Tumor phenotype)
→
were_analyzed_by
→
Object:
electron_microscopy
(Analytical methods)
Original: tumor features#were analyzed by#histology/ immunohistochemistry/ and electron microscopy
#20668
high Confidence
Subject:
tumor_features
(Tumor phenotype)
→
were_analyzed_by
→
Object:
Immunohistochemistry
(Analytical methods)
Original: tumor features#were analyzed by#histology/ immunohistochemistry/ and electron microscopy
#20667
high Confidence
Subject:
tumor_features
(Tumor phenotype)
→
were_analyzed_by
→
Object:
histology
(Analytical methods)
Original: tumor features#were analyzed by#histology/ immunohistochemistry/ and electron microscopy
#20666
high Confidence
Subject:
CD34
(Cell surface molecules)
→
is_positive_in
→
Object:
EHE_case
(Disease Cases)
Original: CD34#is positive in#77.8% of EHE cases
#20665
high Confidence
Subject:
cancer_associated_fibroblasts
(Fibroblasts)
→
are
→
Object:
useful_cytological_finding_for_diagnosing_pancreatic_ductal_adenocarcinoma
(Diagnostic markers)
Original: cancer-associated fibroblasts#are#a useful cytological finding for diagnosing pancreatic ductal adenocarcinoma
#20664
high Confidence
Subject:
Morphological_features
(Histological characteristics)
→
support
→
Object:
diagnosis_of_pilomatrix_carcinoma
(Disease diagnosis)
Original: Morphological features#favor#a diagnosis of pilomatrix carcinoma
#20663
high Confidence
Subject:
T_cells
(T cells)
→
are_typical_of
→
Object:
anaplastic_large_T-cell_lymphoma
(Lymphoma)
Original: Features#are considered typical of#anaplastic large T-cell lymphoma
#20662
high Confidence
Subject:
Autopsy
(Autopsy)
→
disclosed
→
Object:
Postirradiation_sarcoma
(Tumor phenotype)
Original: Autopsy#disclosed#a postirradiation sarcoma in the pituitary area
#20661
high Confidence
Subject:
MGMT
(DNA repair enzymes)
→
is_upregulated_in
→
Object:
Tumor_cells
(Tumor cells)
Original: High proportion of tumor cells#showed#irregular nuclei and large nucleoli/ and gradual increase in MGMT staining
#20660
high Confidence
Subject:
16-year-old_female_patient
(Patient characteristics)
→
was_diagnosed_with
→
Object:
aggressive_Crooke_cell_macroadenoma
(Tumor phenotype)
Original: A 16-year-old female patient#was diagnosed with#an aggressive Crooke cell macroadenoma
#20659
high Confidence
Subject:
maxillofacial_neuroendocrine_carcinoma
(Tumor)
→
characterized_by
→
Object:
poor_prognosis
(Prognostic features)
Original: Maxillofacial neuroendocrine carcinoma#is characterized by#low differentiation/ high malignancy/ and poor prognosis
#20658
high Confidence
Subject:
maxillofacial_neuroendocrine_carcinoma
(Tumor)
→
characterized_by
→
Object:
high_malignancy
(Tumor phenotype)
Original: Maxillofacial neuroendocrine carcinoma#is characterized by#low differentiation/ high malignancy/ and poor prognosis
#20657
high Confidence
Subject:
maxillofacial_neuroendocrine_carcinoma
(Tumor)
→
characterized_by
→
Object:
low_differentiation
(Tumor phenotype)
Original: Maxillofacial neuroendocrine carcinoma#is characterized by#low differentiation/ high malignancy/ and poor prognosis
#20656
high Confidence
Subject:
immunohistochemical_staining
(Immunohistochemistry)
→
showed
→
Object:
CD56
(Protein markers)
Original: Immunohistochemical staining#showed#diffuse expression of CK/ EMA/ Syn/ and CD56
#20655
high Confidence
Subject:
immunohistochemical_staining
(Immunohistochemistry)
→
showed
→
Object:
Syn
(Protein markers)
Original: Immunohistochemical staining#showed#diffuse expression of CK/ EMA/ Syn/ and CD56
#20654
high Confidence
Subject:
immunohistochemical_staining
(Immunohistochemistry)
→
showed
→
Object:
EMA
(Protein markers)
Original: Immunohistochemical staining#showed#diffuse expression of CK/ EMA/ Syn/ and CD56
#20653
high Confidence
Subject:
immunohistochemical_staining
(Immunohistochemistry)
→
showed
→
Object:
CK
(Protein markers)
Original: Immunohistochemical staining#showed#diffuse expression of CK/ EMA/ Syn/ and CD56
#20652
high Confidence
Subject:
patients
(patient)
→
diagnosed_with
→
Object:
maxillofacial_neuroendocrine_carcinoma
(Tumor)
Original: 11 patients#were diagnosed with#maxillofacial neuroendocrine carcinoma
#20651
high Confidence
Subject:
LBC_preparation
(Liquid-based cytology)
→
showed
→
Object:
tumor_cells
(Tumor cells)
Original: LBC preparation#showed#isolated tumor cells with small nucleoli
#20650
high Confidence
Subject:
Electron_microscopy
(Electron microscopy)
→
established
→
Object:
epithelioid_hemangioendothelioma
(Tumor)
Original: Electron microscopy#established#a diagnosis of epithelioid hemangioendothelioma (EHE)
#20649
high Confidence
Subject:
Cytopathologic_examination
(Pathological examination)
→
revealed
→
Object:
plasmacytoid_malignant_cells
(Tumor cells)
Original: Cytopathologic examination#revealed#large undifferentiated plasmacytoid malignant cells with prominent nucleoli
#20648
high Confidence
Subject:
Tumor
(Tumor)
→
is_enriched_with
→
Object:
HER2
(Receptor protein)
Original: One tumor#is enriched with#HER2
#20647
high Confidence
Subject:
Immunohistochemical stain
(Detection Methods)
→
includes
→
Object:
HER2
(Receptor protein)
Original: Immunohistochemical stains#include#estrogen receptor/ progesterone receptor/ HER2/ AR/ endothelial growth factor receptor/ and keratin 5/6
#20646
high Confidence
Subject:
Immunohistochemical stain
(Detection Methods)
→
includes
→
Object:
progesterone receptor
(Receptor protein)
Original: Immunohistochemical stains#include#estrogen receptor/ progesterone receptor/ HER2/ AR/ endothelial growth factor receptor/ and keratin 5/6
#20645
high Confidence
Subject:
Immunohistochemical stain
(Detection Methods)
→
includes
→
Object:
estrogen receptor
(Receptor protein)
Original: Immunohistochemical stains#include#estrogen receptor/ progesterone receptor/ HER2/ AR/ endothelial growth factor receptor/ and keratin 5/6
#20644
high Confidence
Subject:
diagnosis
(Diagnostic Process)
→
is
→
Object:
primary_gastric_Hodgkin_lymphoma
(disease)
Original: diagnosis#is#primary gastric Hodgkin lymphoma
#20643
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
show_nuclear_positivity_for
→
Object:
SALL4
(Transcription Factors)
Original: Tumor cells#show nuclear positivity for#SALL4
#20642
high Confidence
Subject:
EUS-FNA
(Diagnostic techniques)
→
is
→
Object:
useful_method_for_evaluation_of_gastrointestinal_lesions
(Diagnostic Methods)
Original: EUS-FNA#is#a useful method for evaluation of gastrointestinal lesions
#20641
high Confidence
Subject:
cytogenetic_studies
(Genetic analysis)
→
were_consistent_with
→
Object:
t(15;19)(q13;p13.1)
(Chromosomal translocation)
Original: cytogenetic studies#were consistent with#t(15;19)(q13;p13.1) in both cases
#20640
high Confidence
Subject:
cytologic_smear_preparations
(Pathological technology)
→
have_been_used_in
→
Object:
intraoperative_diagnosis_of_CNS_tumors
(Diagnostic techniques)
Original: Cytologic smear preparations#have been used in#the intraoperative diagnosis of central nervous system tumors
#20639
high Confidence
Subject:
FH
(Mitochondrial enzymes)
→
expression_absent_in
→
Object:
tumor_cells
(Tumor cells)
Original: FH expression#was absent in#tumor cells
#20638
high Confidence
Subject:
Hodgkin's_disease
(disease)
→
is_classified_into
→
Object:
mixed_cellularity_type
(Disease classification)
Original: Hodgkin's disease#is classified into#lymphocyte predominant/ nodular sclerosing/ and mixed cellularity types
#20637
high Confidence
Subject:
Hodgkin's_disease
(disease)
→
is_classified_into
→
Object:
nodular_sclerosing_type
(Disease classification)
Original: Hodgkin's disease#is classified into#lymphocyte predominant/ nodular sclerosing/ and mixed cellularity types
#20636
high Confidence
Subject:
Hodgkin's_disease
(disease)
→
is_classified_into
→
Object:
lymphocyte_predominant_type
(Disease classification)
Original: Hodgkin's disease#is classified into#lymphocyte predominant/ nodular sclerosing/ and mixed cellularity types
#20635
high Confidence
Subject:
Askin_tumor
(Tumor)
→
is_diagnosed_by
→
Object:
fine_needle_aspiration_cytology
(Diagnostic Methods)
Original: Askin tumor#is diagnosed by#fine needle aspiration cytology
#20634
high Confidence
Subject:
histologic_diagnosis
(Histological diagnosis)
→
identifies
→
Object:
poroid_hidradenoma
(disease)
Original: Histologic diagnosis#is#poroid hidradenoma
#20633
high Confidence
Subject:
Fine_needle_aspiration_cytology
(Diagnostic techniques)
→
is_diagnostic_for
→
Object:
cutaneous_cystic_lesions
(Cystic skin lesions)
Original: Fine needle aspiration cytology#is diagnostic for#cutaneous cystic lesions
#20632
high Confidence
Subject:
Fine_needle_aspiration_cytology
(Diagnostic techniques)
→
is_used_for
→
Object:
cutaneous_lesions
(Skin lesions)
Original: Fine needle aspiration cytology#is used for#cutaneous lesions
#20631
high Confidence
Subject:
fibrolamellar_hepatocellular_carcinoma
(Hepatocellular carcinoma subtypes)
→
occurs_in
→
Object:
young_patients_with_noncirrhotic_livers
(Patient characteristics)
Original: Fibrolamellar hepatocellular carcinoma#occurs in#young patients with noncirrhotic livers
#20630
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
are_negative_for
→
Object:
neurofilament_protein
(Neurofilament protein)
Original: Neoplastic cells#are negative for#keratin/ chromogranin/ smooth muscle actin/ desmin/ and neurofilament protein
#20629
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
are_negative_for
→
Object:
desmin
(Desmin)
Original: Neoplastic cells#are negative for#keratin/ chromogranin/ smooth muscle actin/ desmin/ and neurofilament protein
#20628
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
are_negative_for
→
Object:
smooth_muscle_actin
(Smooth muscle actin)
Original: Neoplastic cells#are negative for#keratin/ chromogranin/ smooth muscle actin/ desmin/ and neurofilament protein
#20627
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
are_negative_for
→
Object:
Chromogranin
(Neuroendocrine markers)
Original: Neoplastic cells#are negative for#keratin/ chromogranin/ smooth muscle actin/ desmin/ and neurofilament protein
#20626
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
are_negative_for
→
Object:
keratin
(Keratin)
Original: Neoplastic cells#are negative for#keratin/ chromogranin/ smooth muscle actin/ desmin/ and neurofilament protein
#20625
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
are_positive_for
→
Object:
synaptophysin
(Synaptophysin)
Original: Neoplastic cells#are positive for#CD99 and synaptophysin
#20624
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD99
(Cell surface proteins)
Original: Neoplastic cells#are positive for#CD99 and synaptophysin
#20623
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
did_not_express
→
Object:
p63
(Transcription Factors)
Original: Tumor cells#did not express#p63
#20622
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expressed
→
Object:
GCDFP15
(protein)
Original: Tumor cells#expressed#adipophilin/ PRAME (cytoplasmic pattern)/ androgen receptor/ BerEP4/ and GCDFP15
#20621
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expressed
→
Object:
BerEP4
(protein)
Original: Tumor cells#expressed#adipophilin/ PRAME (cytoplasmic pattern)/ androgen receptor/ BerEP4/ and GCDFP15
#20620
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expressed
→
Object:
androgen_receptor
(Receptor protein)
Original: Tumor cells#expressed#adipophilin/ PRAME (cytoplasmic pattern)/ androgen receptor/ BerEP4/ and GCDFP15
#20619
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expressed
→
Object:
PRAME
(protein)
Original: Tumor cells#expressed#adipophilin/ PRAME (cytoplasmic pattern)/ androgen receptor/ BerEP4/ and GCDFP15
#20618
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
expressed
→
Object:
adipophilin
(protein)
Original: Tumor cells#expressed#adipophilin/ PRAME (cytoplasmic pattern)/ androgen receptor/ BerEP4/ and GCDFP15
#20617
high Confidence
Subject:
patients
(patient)
→
presented_with
→
Object:
lymph_node_metastases
(Disease phenotype)
Original: Patients#presented with#multiple lymph node metastases
#20616
high Confidence
Subject:
biopsy_specimen
(Histological samples)
→
contained
→
Object:
adenocarcinoma
(Tumor type)
Original: Biopsy specimens#contained#invasive neoplasm composed of neuroendocrine carcinoma and adenocarcinoma
#20615
high Confidence
Subject:
biopsy_specimen
(Histological samples)
→
contained
→
Object:
neuroendocrine_carcinoma
(Tumor type)
Original: Biopsy specimens#contained#invasive neoplasm composed of neuroendocrine carcinoma and adenocarcinoma
#20614
high Confidence
Subject:
endoscopic_submucosal_dissection
(Endoscopic surgery)
→
revealed
→
Object:
tubular_adenocarcinoma
(Tumor type)
Original: endoscopic submucosal dissection#revealed#tubular adenocarcinoma/ well-differentiated/ with slight submucosal invasion
#20613
high Confidence
Subject:
EWSR1-ATF1
(Gene fusion)
→
is_confirmed_in
→
Object:
malignant_gastrointestinal_neuroectodermal_tumor_case2
(Tumor diseases)
Original: next generation sequencing#confirmed#EWSR1-ATF1 gene fusion in case 2
#20612
high Confidence
Subject:
BCOR-CCNB3-positive_sarcomas
(Tumor diseases)
→
show
→
Object:
CCNB3_immunostaining
(Molecular markers)
Original: BCOR-CCNB3-positive sarcomas#show#CCNB3 immunostaining
#20611
high Confidence
Subject:
tumor
(Tumor tissue)
→
was_labeled_as
→
Object:
malignant_epithelioid_hemangioendothelioma
(Disease phenotype)
Original: tumor#was labeled as#malignant EHE due to spindle cell morphology/ marked cellularity/ and necrosis
#20610
high Confidence
Subject:
FAP
(Genetic disorders)
→
is_associated_with
→
Object:
duodenal_adenoma
(Tumor type)
Original: FAP#is associated with#duodenal adenoma
#20609
high Confidence
Subject:
STK11_gene_alterations
(Gene mutation)
→
are_identified_in
→
Object:
STK11_adnexal_tumor
(Tumor type)
Original: STK11 gene alterations#are identified in#most cases of STK11 adnexal tumor
#20608
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD68
(Surface markers)
Original: Tumor cells#are positive for#myeloperoxidase and CD68
#20607
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
myeloperoxidase
(Enzymes)
Original: Tumor cells#are positive for#myeloperoxidase and CD68
#20606
high Confidence
Subject:
correct_diagnosis
(Diagnosis conclusion)
→
applies_to
→
Object:
fibrolamellar_hepatocellular_carcinoma
(Tumor diseases)
Original: Cytologic findings of FL-HCC#permit#a correct diagnosis of this liver malignancy
#20605
high Confidence
Subject:
cytologic_findings
(Cytological characteristics)
→
permit
→
Object:
correct_diagnosis
(Diagnosis conclusion)
Original: Cytologic findings of FL-HCC#permit#a correct diagnosis of this liver malignancy
#20604
high Confidence
Subject:
Fine needle aspiration
(Fine needle aspiration)
→
reveals
→
Object:
epithelial cells with high nuclear/cytoplasmic ratio
(Cell morphology)
Original: Fine needle aspiration#reveals#epithelial cells with high nuclear/cytoplasmic ratio
#20603
high Confidence
Subject:
Ultrastructural examination
(Cell ultrastructure detection)
→
distinguishes
→
Object:
Hairy cell leukemia
(disease)
Original: Ultrastructural examination#distinguishes#splenic lymphoma with circulating lymphocytes from hairy cell leukemia
#20602
high Confidence
Subject:
Ultrastructural examination
(Cell ultrastructure detection)
→
distinguishes
→
Object:
splenic lymphoma with circulating lymphocytes
(disease)
Original: Ultrastructural examination#distinguishes#splenic lymphoma with circulating lymphocytes from hairy cell leukemia
#20601
high Confidence
Subject:
apocrine_breast_carcinoma
(Breast cancer)
→
shows
→
Object:
ERBB2_expression
(Protein expression)
Original: Apocrine breast carcinomas#show#abundant GCDFP-15/ CEA/ and c-erbB-2 oncoprotein
#20600
high Confidence
Subject:
CA19-9
(Carbohydrate antigen)
→
shows
→
Object:
diffuse_membranous_staining
(Protein expression characteristics)
Original: tumor cells#show#diffuse and strong membranous staining for CK(AE1/AE3)/ CK7/ and CA19-9
#20599
high Confidence
Subject:
CK7
(Cytokeratin)
→
shows
→
Object:
diffuse_membranous_staining
(Protein expression characteristics)
Original: tumor cells#show#diffuse and strong membranous staining for CK(AE1/AE3)/ CK7/ and CA19-9
#20598
high Confidence
Subject:
CK_AE1/AE3
(Cytokeratin)
→
shows
→
Object:
diffuse_membranous_staining
(Protein expression characteristics)
Original: tumor cells#show#diffuse and strong membranous staining for CK(AE1/AE3)/ CK7/ and CA19-9
#20597
high Confidence
Subject:
metanephric_adenoma
(Tumor type)
→
is
→
Object:
benign_renal_neoplasm
(Tumor type)
Original: Metanephric adenoma (MA)#is#a rare benign renal neoplasm
#20596
high Confidence
Subject:
diagnosis_of_prostate_carcinoma
(diagnosis)
→
is_based_on
→
Object:
ancillary_features
(Auxiliary Features)
Original: Diagnosis of prostate carcinoma#is based on#a constellation of architectural/ nuclear/ cytoplasmic/ and ancillary features
#20595
high Confidence
Subject:
apoptotic_bodies
(apoptotic body)
→
should_be_added_to
→
Object:
diagnostic_features_for_prostate_cancer
(Diagnostic features)
Original: Presence of apoptotic bodies#should be added to#diagnostic features for prostate cancer on needle biopsy
#20594
high Confidence
Subject:
fine_needle_aspiration_cytology
(Cytological techniques)
→
is_used_for
→
Object:
diagnosis_of_malignant_rhabdoid_tumor_of_liver
(Disease diagnosis)
Original: malignant rhabdoid tumor of the liver#is diagnosed by#fine needle aspiration cytology
#20593
high Confidence
Subject:
NAT10
(protein)
→
is
→
Object:
nucleolar_protein
(Subcellular structural proteins)
Original: NAT10#is#a nucleolar protein
#20592
high Confidence
Subject:
Nucleolus
(Cellular substructure)
→
contains
→
Object:
ribosomal_proteins
(Ribosomal proteins)
Original: nucleolus#contains#chromosomal NOR/ rRNAs/ and ribosomal proteins
#20591
high Confidence
Subject:
Nucleolus
(Cellular substructure)
→
contains
→
Object:
rRNAs
(Ribosomal RNA)
Original: nucleolus#contains#chromosomal NOR/ rRNAs/ and ribosomal proteins
#20590
high Confidence
Subject:
Nucleolus
(Cellular substructure)
→
contains
→
Object:
chromosomal_NOR
(Nucleolar Organizing Region)
Original: nucleolus#contains#chromosomal NOR/ rRNAs/ and ribosomal proteins
#20589
high Confidence
Subject:
tau_protein
(protein)
→
localizes_to
→
Object:
nucleolus
(Subcellular structure)
Original: tau protein#localizes to#nucleolus in neuroblastomas
#20588
high Confidence
Subject:
hTERT_protein
(protein)
→
localizes_to
→
Object:
nucleoli
(Subcellular structure)
Original: hTERT protein#localizes#to nucleoplasm and nucleoli of cancer cells and proliferating normal cells
#20587
high Confidence
Subject:
hTERT_protein
(protein)
→
localizes_to
→
Object:
nucleoplasm
(Subcellular structure)
Original: hTERT protein#localizes#to nucleoplasm and nucleoli of cancer cells and proliferating normal cells
#20586
high Confidence
Subject:
hTERT_protein
(protein)
→
localizes_to
→
Object:
nucleoli
(Subcellular structure)
Original: hTERT protein#localizes#to nucleoplasm and nucleoli of cancer cells and proliferating normal cells
#20585
high Confidence
Subject:
hTERT_protein
(protein)
→
localizes_to
→
Object:
nucleoplasm
(Subcellular structure)
Original: hTERT protein#localizes#to nucleoplasm and nucleoli of cancer cells and proliferating normal cells
#20584
high Confidence
Subject:
nucleolar_size
(Cell structure phenotype)
→
is
→
Object:
prognostic_measure_of_cancer_disease_severity
(Prognostic indicators)
Original: Nucleolar size#is#a prognostic measure of cancer disease severity
#20583
high Confidence
Subject:
precursor_of_mature_18S_28S_5.8S_ribosomal_RNAs
(Pre-rRNA)
→
is_transcribed_from
→
Object:
ribosomal_DNA_gene
(Genomic DNA)
Original: Precursor of mature 18S/ 28S/ and 5.8S ribosomal RNAs#is transcribed from#ribosomal DNA gene (rDNA)
#20582
high Confidence
Subject:
nucleolus
(Cellular substructure)
→
acts_as
→
Object:
site_of_ribosome_biogenesis
(Cellular Processes)
Original: Nucleoli#act as#sites of ribosome biogenesis and hubs that trap proteins
#20581
high Confidence
Subject:
nucleolus
(Cellular substructure)
→
is_related_to
→
Object:
functions_in_ribosome_biogenesis
(Cellular Processes)
Original: The structure of human nucleoli#is related to#its functions in ribosome biogenesis
#20580
high Confidence
Subject:
nucleolus
(Cellular substructure)
→
produces
→
Object:
Ribosomes
(Ribosome)
Original: The nucleolus#produces#ribosomes
#20579
high Confidence
Subject:
DEPDC1B
(Protein coding genes)
→
is_critical_regulator_of
→
Object:
malignant_progression
(Tumor progression)
Original: DEPDC1B#is a critical regulator of#malignant progression in LUAD
#20578
high Confidence
Subject:
LINC01572_overexpression
(lncRNA expression status)
→
is_associated_with
→
Object:
shorter_overall_survival
(Clinical Outcomes)
Original: LINC01572 overexpression#is associated with#shorter overall survival in LUAD
#20577
high Confidence
Subject:
SPC25
(Protein coding genes)
→
correlates_with
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: SPC25#resulted in#worse prognoses in cancer patients
#20576
high Confidence
Subject:
PTPRB
(Tumor suppressor genes)
→
mutation_is_detected_by
→
Object:
next-generation_sequencing
(Molecular detection technology)
Original: Next-generation sequencing#demonstrated#a novel IGLV2-14/IGLL5 fusion and mutations or deletions in tumor suppressor genes such as PTPRB/ PPP2CB/ and UPK1A
#20575
high Confidence
Subject:
DNAJB1-PRKACA_fusion
(Fusion gene)
→
initiates
→
Object:
tumor_formation
(Tumor development process)
Original: Dnajb1-Prkaca fusion gene#initiates#tumor formation in wild-type mice
#20574
high Confidence
Subject:
DNAJB1
(Protein coding genes)
→
is_fused_with
→
Object:
PRKACA
(Protein coding genes)
Original: 400 Kb deletion on chromosome 19#fuses#DNAJB1 and PRKACA genes in FL-HCC patients
#20573
high Confidence
Subject:
PTEN
(Protein coding genes)
→
mutation_results_in
→
Object:
benign_hamartomas
(Benign hamartoma)
Original: Germline PTEN mutations#result in#cancer predisposition/ macrocephaly/ and benign hamartomas
#20572
high Confidence
Subject:
PTEN
(Protein coding genes)
→
mutation_results_in
→
Object:
macrocephaly
(Clinical phenotype - macrocephaly)
Original: Germline PTEN mutations#result in#cancer predisposition/ macrocephaly/ and benign hamartomas
#20571
high Confidence
Subject:
PTEN
(Protein coding genes)
→
mutation_results_in
→
Object:
cancer_predisposition
(Cancer susceptibility)
Original: Germline PTEN mutations#result in#cancer predisposition/ macrocephaly/ and benign hamartomas
#20570
high Confidence
Subject:
homozygous_mutant_embryos
(Embryo)
→
fail_to_develop_beyond
→
Object:
morula_stage
(Embryonic development stages)
Original: Homozygous mutant embryos#failed to develop#beyond the morula stage
#20569
high Confidence
Subject:
NPM1_gene
(Protein coding genes)
→
is_mutated_in
→
Object:
Leukemia
(Tumor phenotype)
Original: NPM1 gene#is translocated or mutated in#lymphomas and leukemias
#20568
high Confidence
Subject:
NPM1_gene
(Protein coding genes)
→
is_translocated_in
→
Object:
lymphoma
(Tumor phenotype)
Original: NPM1 gene#is translocated or mutated in#lymphomas and leukemias
#20567
high Confidence
Subject:
AT8_epitope_of_Tau
(Protein modified epitope)
→
is_marker_of
→
Object:
neuronal_cell_differentiation
(Cell differentiation process)
Original: AT8 epitope of Tau#is a marker of#neuronal cell differentiation
#20566
high Confidence
Subject:
Ribosomal_proteins
(Structural proteins)
→
localize_in
→
Object:
nucleolus
(Cellular substructure)
Original: Ribosomal proteins#assemble on#precursor rRNAs in nucleolus
#20565
high Confidence
Subject:
Ribosomal_proteins
(Structural proteins)
→
assemble_on
→
Object:
precursor_rRNAs
(Noncoding RNA)
Original: Ribosomal proteins#assemble on#precursor rRNAs in nucleolus
#20564
high Confidence
Subject:
Dense_fibrillar_component
(Cellular substructure)
→
is_revealed_within
→
Object:
nucleolus
(Cellular substructure)
Original: Dense fibrillar component#is revealed within#nucleolus
#20563
high Confidence
Subject:
Nucleolus
(Cellular substructure)
→
is_found_in
→
Object:
human_cancers
(Disease phenotype)
Original: Nucleolus#is found in#a broad range of human cancers
#20562
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
has
→
Object:
granular_component
(Substructure)
Original: Nucleolus#has#a tripartite organization: fibrillar center/ dense fibrillar component/ granular component
#20561
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
has
→
Object:
dense_fibrillar_component
(Substructure)
Original: Nucleolus#has#a tripartite organization: fibrillar center/ dense fibrillar component/ granular component
#20560
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
has
→
Object:
fibrillar_center
(Substructure)
Original: Nucleolus#has#a tripartite organization: fibrillar center/ dense fibrillar component/ granular component
#20559
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
assembles
→
Object:
ribosomal_RNAs_with_ribosomal_proteins
(Ribosome assembly)
Original: Nucleolus#synthesizes/ processes/ and assembles#ribosomal RNAs with ribosomal proteins
#20558
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
processes
→
Object:
ribosomal_RNAs
(RNA molecules)
Original: Nucleolus#synthesizes/ processes/ and assembles#ribosomal RNAs with ribosomal proteins
#20557
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
synthesizes
→
Object:
ribosomal_RNAs
(RNA molecules)
Original: Nucleolus#synthesizes/ processes/ and assembles#ribosomal RNAs with ribosomal proteins
#20556
high Confidence
Subject:
PML
(protein)
→
organize
→
Object:
PML_nuclear_bodies
(Subcellular structure)
Original: PML#organizes#PML nuclear bodies
#20555
high Confidence
Subject:
homeoproteins
(Transcription Factors)
→
act_as
→
Object:
transcription_factors
(Transcription Factors)
Original: Hox genes#encode#homeoproteins that act as transcription factors
#20554
high Confidence
Subject:
Hox_genes
(Protein coding genes)
→
encode
→
Object:
homeoproteins
(Transcription Factors)
Original: Hox genes#encode#homeoproteins that act as transcription factors
#20553
high Confidence
Subject:
Western-blot_analysis
(Molecular analysis technology)
→
determines
→
Object:
p53_expression
(Protein expression)
Original: Western-blot analysis#determines#cell senescence-related markers (p16/ p21/ p53)
#20552
high Confidence
Subject:
Western-blot_analysis
(Molecular analysis technology)
→
determines
→
Object:
p21_expression
(Protein expression)
Original: Western-blot analysis#determines#cell senescence-related markers (p16/ p21/ p53)
#20551
high Confidence
Subject:
Western-blot_analysis
(Molecular analysis technology)
→
determines
→
Object:
p16_expression
(Protein expression)
Original: Western-blot analysis#determines#cell senescence-related markers (p16/ p21/ p53)
#20550
high Confidence
Subject:
Western_blotting
(Molecular analysis technology)
→
determines
→
Object:
vimentin_expression
(Protein expression)
Original: Western blotting#determines#expression levels of BAX/ BCL2/ Caspase9/ E-cadherin/ N-cadherin/ PI3K/ AKT/ and vimentin
#20549
high Confidence
Subject:
Western_blotting
(Molecular analysis technology)
→
determines
→
Object:
AKT_expression
(Protein expression)
Original: Western blotting#determines#expression levels of BAX/ BCL2/ Caspase9/ E-cadherin/ N-cadherin/ PI3K/ AKT/ and vimentin
#20548
high Confidence
Subject:
Western_blotting
(Molecular analysis technology)
→
determines
→
Object:
PI3K_expression
(Protein expression)
Original: Western blotting#determines#expression levels of BAX/ BCL2/ Caspase9/ E-cadherin/ N-cadherin/ PI3K/ AKT/ and vimentin
#20547
high Confidence
Subject:
Western_blotting
(Molecular analysis technology)
→
determines
→
Object:
N-cadherin_expression
(Protein expression)
Original: Western blotting#determines#expression levels of BAX/ BCL2/ Caspase9/ E-cadherin/ N-cadherin/ PI3K/ AKT/ and vimentin
#20546
high Confidence
Subject:
Western_blotting
(Molecular analysis technology)
→
determines
→
Object:
E-cadherin_expression
(Protein expression)
Original: Western blotting#determines#expression levels of BAX/ BCL2/ Caspase9/ E-cadherin/ N-cadherin/ PI3K/ AKT/ and vimentin
#20545
high Confidence
Subject:
Western_blotting
(Molecular analysis technology)
→
determines
→
Object:
Caspase9_expression
(Protein expression)
Original: Western blotting#determines#expression levels of BAX/ BCL2/ Caspase9/ E-cadherin/ N-cadherin/ PI3K/ AKT/ and vimentin
#20544
high Confidence
Subject:
Western_blotting
(Molecular analysis technology)
→
determines
→
Object:
BCL2_expression
(Protein expression)
Original: Western blotting#determines#expression levels of BAX/ BCL2/ Caspase9/ E-cadherin/ N-cadherin/ PI3K/ AKT/ and vimentin
#20543
high Confidence
Subject:
Western_blotting
(Molecular analysis technology)
→
determines
→
Object:
BAX_expression
(Protein expression)
Original: Western blotting#determines#expression levels of BAX/ BCL2/ Caspase9/ E-cadherin/ N-cadherin/ PI3K/ AKT/ and vimentin
#20542
high Confidence
Subject:
UBA2
(Protease)
→
is_overexpressed_in
→
Object:
glioma_cell_lines
(Tumor cell lines)
Original: UBA2#is overexpressed in#glioma tissues and cell lines
#20541
high Confidence
Subject:
UBA2
(Protease)
→
is_overexpressed_in
→
Object:
glioma_tissues
(Tumor tissue)
Original: UBA2#is overexpressed in#glioma tissues and cell lines
#20540
high Confidence
Subject:
UBA2
(Protease)
→
is_involved_in
→
Object:
SUMOylation_of_proteins
(Protein post-translational modification)
Original: UBA2#is involved in#SUMOylation of proteins
#20539
high Confidence
Subject:
VEGFR
(Receptor protein)
→
functions_in
→
Object:
tumor_angiogenesis
(Tumor angiogenesis)
Original: VEGFR#functions in#tumor angiogenesis
#20538
high Confidence
Subject:
CD2
(Immune receptor proteins)
→
is
→
Object:
most_important_prognostic_gene
(Genome level)
Original: CD2#is#the most important prognostic gene among risk signatures
#20537
high Confidence
Subject:
tumor_immune_microenvironment
(Tissue Microenvironment)
→
performs
→
Object:
treatment_effectiveness
(Response to treatment)
Original: Tumor immune microenvironment (TME)#performs#a critical function in the prediction of clinical outcomes and treatment effectiveness
#20536
high Confidence
Subject:
tumor_immune_microenvironment
(Tissue Microenvironment)
→
performs
→
Object:
prediction_of_clinical_outcomes
(Clinical Outcomes)
Original: Tumor immune microenvironment (TME)#performs#a critical function in the prediction of clinical outcomes and treatment effectiveness
#20535
high Confidence
Subject:
CST1
(Caspase inhibitors)
→
is_significantly_elevated_in
→
Object:
serum
(serum)
Original: CST1 expression#was significantly elevated in#ESCC tissues and serum
#20534
high Confidence
Subject:
CST1
(Caspase inhibitors)
→
is_significantly_elevated_in
→
Object:
ESCC_tissues
(Tumor tissue)
Original: CST1 expression#was significantly elevated in#ESCC tissues and serum
#20533
high Confidence
Subject:
Ultrasound-guided_FNAC
(Diagnostic techniques)
→
has_revolutionized
→
Object:
management_of_cancers
(Tumor Management)
Original: Ultrasound-guided FNAC#has revolutionized#management of cancers
#20532
high Confidence
Subject:
hybrid_oncogene_of_thyrotropin_beta-subunit_and_SV40_large_T-antigen
(Chimeric oncogene)
→
induces
→
Object:
pituitary_tumorigenesis
(Tumor development process)
Original: Hybrid oncogene of thyrotropin beta-subunit and SV40 large T-antigen#induces#pituitary tumorigenesis in transgenic mice
#20531
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
decreases
→
Object:
melanoma_cell_size
(Cell phenotype)
Original: GSK2118436 treatment#decreased#melanoma cell size
#20530
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN1C_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20529
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN1B_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20528
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN1A_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20527
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN2A_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20526
high Confidence
Subject:
MDMX
(protein)
→
promotes
→
Object:
resistance_to_5_fluorouracil
(Drug resistance)
Original: MDMX expression#promotes#resistance to 5-fluorouracil
#20525
high Confidence
Subject:
RNA_polymerase_I_transcriptional_complex
(Transcription complex)
→
is_inhibited_by
→
Object:
actinomycin_D
(Small molecule drugs)
Original: Fluorescence of RNA polymerase I transcriptional complexes#was diminished by#actinomycin D
#20524
high Confidence
Subject:
HkDJ
(drug)
→
is_known_to_be
→
Object:
photosensitizing
(Side effects of medication)
Original: HCTZ#is known to be#photosensitizing
#20523
high Confidence
Subject:
p4E-BP1
(Phosphorylated proteins)
→
is_expressed_in
→
Object:
ductal_adenocarcinoma
(Tumor type)
Original: mTOR/ 4E-BP1/ and p4E-BP1#were expressed in#ductal adenocarcinoma
#20522
high Confidence
Subject:
eIF4EBP1
(Transcriptional regulatory proteins)
→
is_expressed_in
→
Object:
ductal_adenocarcinoma
(Tumor type)
Original: mTOR/ 4E-BP1/ and p4E-BP1#were expressed in#ductal adenocarcinoma
#20521
high Confidence
Subject:
MTOR
(Protein kinase)
→
is_expressed_in
→
Object:
ductal_adenocarcinoma
(Tumor type)
Original: mTOR/ 4E-BP1/ and p4E-BP1#were expressed in#ductal adenocarcinoma
#20520
high Confidence
Subject:
MYB
(Protein coding genes)
→
high_expression_suggests
→
Object:
targeted_therapy_for_ACC
(Treatment options)
Original: High expression of MYB transcription factors#suggests#targeted approaches for ACC therapy
#20519
high Confidence
Subject:
MYC
(Protein coding genes)
→
increased_expression_in
→
Object:
invasive_breast_carcinoma
(Disease phenotype)
Original: FISH analysis#demonstrated#increased (>5) C-MYC signals per nucleus
#20518
high Confidence
Subject:
MYC
(Protein coding genes)
→
amplified_in
→
Object:
invasive_breast_carcinoma
(Disease phenotype)
Original: C-MYC amplification#was identified in#18 additional cases of invasive breast carcinomas
#20517
high Confidence
Subject:
NPM1
(Nucleolar phosphoprotein)
→
is_mutated_in
→
Object:
AML_patients
(patient)
Original: NPM#is mutated in#one third of AML patients
#20516
high Confidence
Subject:
PHE_tissues
(Tissue samples)
→
expresses
→
Object:
ERG
(Transcription Factors)
Original: PHE tissues#expressed#CD31 and ERG
#20515
high Confidence
Subject:
PHE_tissues
(Tissue samples)
→
expresses
→
Object:
CD31
(Endothelial marker protein)
Original: PHE tissues#expressed#CD31 and ERG
#20514
high Confidence
Subject:
PROX1
(Transcription Factors)
→
plays_important_role_in
→
Object:
cancer_metastasis
(Tumor development process)
Original: PROX1#plays an important role in#invasion and metastasis of many human cancers
#20513
high Confidence
Subject:
PROX1
(Transcription Factors)
→
plays_important_role_in
→
Object:
cancer_invasion
(Tumor development process)
Original: PROX1#plays an important role in#invasion and metastasis of many human cancers
#20512
high Confidence
Subject:
tumor_sample
(Tumor specimens)
→
underwent
→
Object:
next-generation_sequencing
(Molecular detection technology)
Original: Seven tumors#underwent#next-generation sequencing of 480 cancer-associated genes
#20511
high Confidence
Subject:
NPM1
(Protein coding genes)
→
is_mutated_in
→
Object:
NPM1c+_AML_cells
(Tumor cells)
Original: Cytoplasmic accumulation of APE1#is associated with#NPM1c+ AML and other cancers
#20510
high Confidence
Subject:
PIK3CA
(Protein coding genes)
→
is_highly_expressed_in
→
Object:
endometrial_cancer_cells
(Tumor cells)
Original: p110α#is highly expressed in#endometrial cancer (EC) cell lines and primary tumors
#20509
high Confidence
Subject:
XIAP
(Inhibitor of apoptosis protein)
→
is_member_of
→
Object:
inhibitor_of_apoptosis_proteins_family
(Protein family)
Original: XIAP#is a member of#inhibitor of apoptosis proteins family
#20508
high Confidence
Subject:
desmin
(Intermediate filament protein)
→
are_expressed_in
→
Object:
tumor_cases
(Tumor Cases)
Original: All cases#expressed#keratins/ S-100 protein/ calponin/ EMA/ GFAP/ SMA/ p63/ desmin
#20507
high Confidence
Subject:
p63
(Transcription Factors)
→
are_expressed_in
→
Object:
tumor_cases
(Tumor Cases)
Original: All cases#expressed#keratins/ S-100 protein/ calponin/ EMA/ GFAP/ SMA/ p63/ desmin
#20506
high Confidence
Subject:
SMA
(Smooth muscle actin)
→
are_expressed_in
→
Object:
tumor_cases
(Tumor Cases)
Original: All cases#expressed#keratins/ S-100 protein/ calponin/ EMA/ GFAP/ SMA/ p63/ desmin
#20505
high Confidence
Subject:
GFAP
(glial fibrillary acid protein)
→
are_expressed_in
→
Object:
tumor_cases
(Tumor Cases)
Original: All cases#expressed#keratins/ S-100 protein/ calponin/ EMA/ GFAP/ SMA/ p63/ desmin
#20504
high Confidence
Subject:
EMA
(Epithelial membrane antigen)
→
are_expressed_in
→
Object:
tumor_cases
(Tumor Cases)
Original: All cases#expressed#keratins/ S-100 protein/ calponin/ EMA/ GFAP/ SMA/ p63/ desmin
#20503
high Confidence
Subject:
calponin
(Cytoskeletal proteins)
→
are_expressed_in
→
Object:
tumor_cases
(Tumor Cases)
Original: All cases#expressed#keratins/ S-100 protein/ calponin/ EMA/ GFAP/ SMA/ p63/ desmin
#20502
high Confidence
Subject:
S-100_protein
(Calcium Binding Protein)
→
are_expressed_in
→
Object:
tumor_cases
(Tumor Cases)
Original: All cases#expressed#keratins/ S-100 protein/ calponin/ EMA/ GFAP/ SMA/ p63/ desmin
#20501
high Confidence
Subject:
keratins
(Cytoskeletal proteins)
→
are_expressed_in
→
Object:
tumor_cases
(Tumor Cases)
Original: All cases#expressed#keratins/ S-100 protein/ calponin/ EMA/ GFAP/ SMA/ p63/ desmin
#20500
high Confidence
Subject:
BRAF_V600E_mutation
(Gene mutation)
→
is_frequent_in
→
Object:
oncocytic_tumors
(Tumor type)
Original: BRAF V600E mutation#is frequent in#oncocytic tumors
#20499
high Confidence
Subject:
RET
(Receptor tyrosine kinases)
→
forms_fusion_with
→
Object:
TRIM33
(Ubiquitin ligase)
Original: TRIM33::RET fusion#is frequent in#oncocytic tumors
#20498
high Confidence
Subject:
TRIM33::RET_fusion
(Gene fusion)
→
is_frequent_in
→
Object:
oncocytic_tumors
(Tumor type)
Original: TRIM33::RET fusion#is frequent in#oncocytic tumors
#20497
high Confidence
Subject:
RET
(Receptor tyrosine kinases)
→
forms_fusion_with
→
Object:
NCOA4
(Transcription activator)
Original: NCOA4::RET fusion#is frequent in#intercalated duct-like tumors
#20496
high Confidence
Subject:
NCOA4::RET_fusion
(Gene fusion)
→
is_frequent_in
→
Object:
intercalated_duct-like_tumors
(Tumor type)
Original: NCOA4::RET fusion#is frequent in#intercalated duct-like tumors
#20495
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
strongly_express
→
Object:
GLUT1
(Transporter)
Original: Tumor cells#strongly expressed#PAX8/ vimentin/ CD10/ and GLUT1
#20494
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
strongly_express
→
Object:
CD10
(Cell surface molecules)
Original: Tumor cells#strongly expressed#PAX8/ vimentin/ CD10/ and GLUT1
#20493
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
strongly_express
→
Object:
VIM
(Cytoskeletal proteins)
Original: Tumor cells#strongly expressed#PAX8/ vimentin/ CD10/ and GLUT1
#20492
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
strongly_express
→
Object:
PAX8
(Transcription Factors)
Original: Tumor cells#strongly expressed#PAX8/ vimentin/ CD10/ and GLUT1
#20491
high Confidence
Subject:
SWI/SNF_chromatin_remodeling_complex
(Protein complex)
→
suppresses
→
Object:
human_cancers
(disease)
Original: SWI/SNF chromatin remodeling complex#has#tumor suppressor roles in human cancers
#20490
high Confidence
Subject:
cellular_proliferation
(Cellular Processes)
→
gains_importance_for
→
Object:
cancer_prognosis_prediction
(Clinical Outcomes)
Original: Cellular proliferation information#gains#importance for predicting cancer prognosis
#20489
high Confidence
Subject:
cell_proliferation
(Cellular Processes)
→
increases_as
→
Object:
HCC_progression
(Disease progression)
Original: Cell proliferation#increases as#HCC progresses
#20488
high Confidence
Subject:
TP53
(Tumor suppressor genes)
→
is_overexpressed_in
→
Object:
HCC_tumors
(Tumor tissue)
Original: p53 overexpression#was observed in#22.5% of tumors
#20487
high Confidence
Subject:
XCdc14beta
(Protein coding genes)
→
is_required_for
→
Object:
normal_cell_division
(Cell division)
Original: XCdc14alpha/beta#are required for#normal cellular division
#20486
high Confidence
Subject:
XCdc14alpha
(Protein coding genes)
→
is_required_for
→
Object:
normal_cell_division
(Cell division)
Original: XCdc14alpha/beta#are required for#normal cellular division
#20485
high Confidence
Subject:
hCdc14B
(Protein coding genes)
→
is_homologue_of
→
Object:
human_Cdc14
(Protein coding genes)
Original: hCdc14A and hCdc14B#are#human Cdc14 homologues
#20484
high Confidence
Subject:
hCdc14A
(Protein coding genes)
→
is_homologue_of
→
Object:
human_Cdc14
(Protein coding genes)
Original: hCdc14A and hCdc14B#are#human Cdc14 homologues
#20483
high Confidence
Subject:
Cdc14_phosphatase
(Phosphatase)
→
regulates
→
Object:
late_mitotic_events
(Cell cycle process)
Original: Cdc14 phosphatase#regulates#late mitotic events in eukaryotes
#20482
high Confidence
Subject:
AgNOR_protein
(Protein complex)
→
has
→
Object:
prognostic_significance
(Prognostic significance)
Original: AgNOR proteins#have#prognostic significance in stage II-III rectal cancers
#20481
high Confidence
Subject:
cancer_treatment_modality
(Treatment interventions)
→
induces
→
Object:
apoptosis
(Cell death process)
Original: Cancer treatment modalities#induce#apoptosis in sensitive cells
#20480
high Confidence
Subject:
apoptotic_cell_death
(Cell death process)
→
plays_critical_role_in
→
Object:
tissue_homeostasis
(Tissue homeostasis)
Original: Apoptotic cell death#plays#a role in maintaining tissue homeostasis
#20479
high Confidence
Subject:
p53
(Tumor suppressor proteins)
→
accumulates_in
→
Object:
erythroid_progenitor_cells
(Hematopoietic progenitor cells)
Original: Nuclear p53 staining#accumulates in#erythroid progenitor cells in DBA or del(5q) patients
#20478
high Confidence
Subject:
Nutlin-3
(Small molecule drugs)
→
impairs
→
Object:
Erythropoiesis
(Hematopoietic physiological process)
Original: Nutlin-3#impairs#erythropoiesis by activating p53
#20477
high Confidence
Subject:
PI3K_signaling_pathway
(signaling pathway)
→
modulates
→
Object:
cell_survival
(Cellular Processes)
Original: PI3K signaling pathway#modulates#growth/ proliferation/ and cell survival
#20476
high Confidence
Subject:
PI3K_signaling_pathway
(signaling pathway)
→
modulates
→
Object:
proliferation
(Cellular Processes)
Original: PI3K signaling pathway#modulates#growth/ proliferation/ and cell survival
#20475
high Confidence
Subject:
PI3K_signaling_pathway
(signaling pathway)
→
modulates
→
Object:
growth
(Cellular Processes)
Original: PI3K signaling pathway#modulates#growth/ proliferation/ and cell survival
#20474
high Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
depletion
→
Object:
rDNA_transcription
(Transcription process)
Original: Depletion of nucleolin#inhibits#rDNA transcription
#20473
high Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
is_highly_expressed_in
→
Object:
cancer_cell_lines
(Cell Type)
Original: Nucleolin#is highly expressed in#rapidly dividing cells and cancer cell lines
#20472
high Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
is_highly_expressed_in
→
Object:
rapidly_dividing_cells
(Cell Type)
Original: Nucleolin#is highly expressed in#rapidly dividing cells and cancer cell lines
#20471
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion_by
→
Object:
AVN-944
(Chemotherapy drugs)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#translocation of nucleolar proteins to the nucleoplasm
#20470
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion_by
→
Object:
MPA
(Chemotherapy drugs)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#translocation of nucleolar proteins to the nucleoplasm
#20469
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion_by
→
Object:
AVN-944
(Chemotherapy drugs)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#a reduction in levels of 45S precursor rRNA synthesis
#20468
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion_by
→
Object:
MPA
(Chemotherapy drugs)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#a reduction in levels of 45S precursor rRNA synthesis
#20467
high Confidence
Subject:
BLM
(DNA helicase)
→
mutation_causes
→
Object:
cancer-prone_syndromes
(Disease phenotype)
Original: Mutations in WRN and BLM#cause#cancer-prone syndromes
#20466
high Confidence
Subject:
WRN
(DNA helicase)
→
mutation_causes
→
Object:
cancer-prone_syndromes
(Disease phenotype)
Original: Mutations in WRN and BLM#cause#cancer-prone syndromes
#20465
high Confidence
Subject:
ZDS1
(Protein coding genes)
→
promotes
→
Object:
PPP2CB
(Protein coding genes)
Original: Separase together with Zds1p#promotes#downregulation of PP2A(Cdc55) in early anaphase
#20464
high Confidence
Subject:
ESPL1
(Protein coding genes)
→
promotes
→
Object:
PPP2CB
(Protein coding genes)
Original: Separase together with Zds1p#promotes#downregulation of PP2A(Cdc55) in early anaphase
#20463
high Confidence
Subject:
ZDS1
(Protein coding genes)
→
regulates
→
Object:
CDC14
(Protein coding genes)
Original: Zds1#regulates#PP2A(Cdc55) activity and Cdc14 activation during mitotic exit
#20462
high Confidence
Subject:
ZDS1
(Protein coding genes)
→
regulates
→
Object:
PPP2CB
(Protein coding genes)
Original: Zds1#regulates#PP2A(Cdc55) activity and Cdc14 activation during mitotic exit
#20461
high Confidence
Subject:
human_genome
(Genome)
→
contains
→
Object:
APOBEC_cytidine_deaminases
(Deaminase family)
Original: The human genome#contains#11 APOBEC cytidine deaminases classified into four families
#20460
high Confidence
Subject:
ALLN
(Proteasome inhibitors)
→
inhibits
→
Object:
Survivin-deltaEx3_degradation
(Protein degradation process)
Original: Proteasome inhibitors MG132 or ALLN#inhibit#degradation of Survivin-deltaEx3
#20459
high Confidence
Subject:
MG132
(Proteasome inhibitors)
→
inhibits
→
Object:
Survivin-deltaEx3_degradation
(Protein degradation process)
Original: Proteasome inhibitors MG132 or ALLN#inhibit#degradation of Survivin-deltaEx3
#20458
high Confidence
Subject:
ATR
(Protein kinase)
→
phosphorylates
→
Object:
PML
(Tumor suppressor proteins)
Original: ATR#phosphorylates#PML
#20457
high Confidence
Subject:
PML
(Tumor suppressor proteins)
→
enhances
→
Object:
p53_stability
(Protein stability)
Original: PML#enhances#p53 stability
#20456
high Confidence
Subject:
PML
(Tumor suppressor proteins)
→
potentiates
→
Object:
p53_function
(Protein function)
Original: PML tumour-suppressor protein#potentiates#p53 function
#20455
high Confidence
Subject:
NPM1
(Protein coding genes)
→
is_critical_in
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: Nucleophosmin (NPM)#is critical in#ribosome biogenesis
#20454
high Confidence
Subject:
TP53
(Protein coding genes)
→
is_localized_to
→
Object:
nucleus
(Cellular substructure)
Original: p53#is localized to#the nucleus of human fibroblasts treated with UV light/ DRB/ or MG132
#20453
high Confidence
Subject:
TP53
(Transcription Factors)
→
accumulates_in
→
Object:
nucleus
(Cell structure)
Original: p53#accumulates in#the nucleus of cells exposed to various cellular stresses
#20452
high Confidence
Subject:
RPS17
(Ribosomal proteins)
→
contains
→
Object:
nuclear_localization_signal
(Protein domain)
Original: RPS17#contains#two nuclear localization signals (NLSs)
#20451
high Confidence
Subject:
regulatory_pathways
(Signaling pathway network)
→
govern
→
Object:
cell_cycle_stages
(Cell cycle phase)
Original: Regulatory pathways#govern#the functioning of cell cycle stages
#20450
high Confidence
Subject:
MMP2
(Protease)
→
downregulates
→
Object:
preribosomal_RNA_transcription
(Transcription process)
Original: Inhibition of matrix metalloproteinase-2#downregulates#preribosomal RNA transcription
#20449
high Confidence
Subject:
nucleolus
(Cellular substructure)
→
has_central_role_in
→
Object:
ribosome_biogenesis
(Molecular complex synthesis process)
Original: Nucleolus#has a central role in#ribosome biogenesis
#20448
high Confidence
Subject:
TP53
(Tumor suppressor genes)
→
is_involved_in
→
Object:
oncogenesis
(Tumorigenesis)
Original: GLTSCR2#is involved in#oncogenesis with p53/ NPM/ and MYC
#20447
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
plays_central_role_in
→
Object:
DNA_damage_repair
(DNA damage repair)
Original: Nucleolus#plays a central role in#DNA damage repair
#20446
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
plays_central_role_in
→
Object:
cell_proliferation
(Cellular Processes)
Original: Nucleolus#plays a central role in#cell proliferation
#20445
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
plays_central_role_in
→
Object:
cell_cycle_regulation
(Cell cycle regulation)
Original: Nucleolus#plays a central role in#cell cycle regulation
#20444
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
plays_central_role_in
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: Nucleolus#plays a central role in#ribosome biogenesis
#20443
high Confidence
Subject:
TP53
(Tumor suppressor proteins)
→
silenced_in
→
Object:
human_cancers
(Tumor phenotype)
Original: Silencing of retinoblastoma protein and p53 pathways#is associated with#the development of human cancers
#20442
high Confidence
Subject:
RB1
(Tumor suppressor proteins)
→
silenced_in
→
Object:
human_cancers
(Tumor phenotype)
Original: Silencing of retinoblastoma protein and p53 pathways#is associated with#the development of human cancers
#20441
high Confidence
Subject:
mTORC1
(Protein complex)
→
regulates
→
Object:
ribosome_biogenesis_events_in_nucleoli
(Nucleolar ribosome)
Original: mTORC1#regulates#ribosome biogenesis events in nucleoli
#20440
high Confidence
Subject:
YAP
(Transcription regulator)
→
functions_as
→
Object:
nuclear_effector_of_Hippo_signaling
(Downstream effector molecules of signaling pathways)
Original: YAP#functions as#a nuclear effector of Hippo signaling pathway
#20439
high Confidence
Subject:
CRM1
(Nuclear export receptors)
→
transports
→
Object:
cargo_molecules
(Transport substrate)
Original: CRM1#transports#cargo molecules from nucleus to cytoplasm
#20438
high Confidence
Subject:
TIF-IA
(Transcription Factors)
→
mediates
→
Object:
rRNA_synthesis
(RNA synthesis process)
Original: Growth-dependent regulation of rRNA synthesis#is mediated by#TIF-IA
#20437
high Confidence
Subject:
TP53
(Tumor suppressor genes)
→
leads_to
→
Object:
apoptosis
(Apoptosis)
Original: Tumor suppressor p53 expression#leads to#cell cycle arrest in G1/G0 phase followed by apoptosis
#20436
high Confidence
Subject:
TP53
(Tumor suppressor genes)
→
leads_to
→
Object:
cell_cycle_arrest_in_G1_G0_phase
(Cell cycle process)
Original: Tumor suppressor p53 expression#leads to#cell cycle arrest in G1/G0 phase followed by apoptosis
#20435
high Confidence
Subject:
nucleolus
(Nuclear structure)
→
responsible_for
→
Object:
ribosome_assembly
(Molecular complex assembly)
Original: The nucleolus#is responsible for#ribosomal RNA transcription/ processing/ and ribosome assembly
#20434
high Confidence
Subject:
nucleolus
(Nuclear structure)
→
responsible_for
→
Object:
rRNA_processing
(Process)
Original: The nucleolus#is responsible for#ribosomal RNA transcription/ processing/ and ribosome assembly
#20433
high Confidence
Subject:
nucleolus
(Nuclear structure)
→
responsible_for
→
Object:
ribosomal_RNA_transcription
(Transcription process)
Original: The nucleolus#is responsible for#ribosomal RNA transcription/ processing/ and ribosome assembly
#20432
high Confidence
Subject:
Oxaliplatin
(Chemotherapy drugs)
→
inhibits
→
Object:
rRNA_synthesis_by_POLR1
(Transcription process)
Original: Oxaliplatin#significantly inhibits#rRNA synthesis by Pol I
#20431
high Confidence
Subject:
ERK2_signaling_pathway
(signaling pathway)
→
plays_significant_role_in
→
Object:
male_reproduction
(Male reproductive function)
Original: ERK1/2 signaling pathway#plays#a significant role in male reproduction
#20430
high Confidence
Subject:
ERK1_signaling_pathway
(signaling pathway)
→
plays_significant_role_in
→
Object:
male_reproduction
(Male reproductive function)
Original: ERK1/2 signaling pathway#plays#a significant role in male reproduction
#20429
high Confidence
Subject:
TP53_targeting_pharmacological_compounds
(drug)
→
have_been_explored_in
→
Object:
clinical_trials
(Clinical trials)
Original: clinical trials of pharmacological compounds targeting TP53#have been#explored
#20428
high Confidence
Subject:
NPM1
(Nucleolar proteins)
→
plays_key_role_in
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: NPM1#plays key roles in#ribosome biogenesis/ centrosome duplication/ genomic stability/ cell cycle progression/ and apoptosis
#20427
high Confidence
Subject:
STAT5
(Transcription Factors)
→
is_involved_in
→
Object:
JAK/STAT_pathway
(signaling pathway)
Original: Signal transduction pathways#involve#PI3K/Akt/ STAT3/ and STAT5 proteins
#20426
high Confidence
Subject:
STAT3
(Transcription Factors)
→
is_involved_in
→
Object:
JAK/STAT_pathway
(signaling pathway)
Original: Signal transduction pathways#involve#PI3K/Akt/ STAT3/ and STAT5 proteins
#20425
high Confidence
Subject:
AKT1
(Protein kinase)
→
is_involved_in
→
Object:
PI3K/AKT_pathway
(signaling pathway)
Original: Signal transduction pathways#involve#PI3K/Akt/ STAT3/ and STAT5 proteins
#20424
high Confidence
Subject:
PIK3CA
(Protein kinase)
→
is_involved_in
→
Object:
PI3K/AKT_pathway
(signaling pathway)
Original: Signal transduction pathways#involve#PI3K/Akt/ STAT3/ and STAT5 proteins
#20423
high Confidence
Subject:
DNase_I
(Endonuclease)
→
partially_digests
→
Object:
DNA
(Nucleic Acids)
Original: DNase I#partially digests#DNA during CDN preparation
#20422
high Confidence
Subject:
Fibrillarin
(Ribosomal proteases)
→
performs
→
Object:
ribomethylation in eukaryotic ribosomes
(Molecular modification events)
Original: Fibrillarin#performs#ribomethylation in eukaryotic ribosomes
#20421
high Confidence
Subject:
Nucleolin lactylation
(Protein post-translational modification)
→
promotes
→
Object:
invasion of iCCA cells
(Cellular Processes)
Original: Nucleolin lactylation#promotes#invasion of iCCA cells
#20420
high Confidence
Subject:
NCL
(Ribosomal proteins)
→
correlates_with
→
Object:
iCCA_progression
(Disease phenotype)
Original: Nucleolin#correlates with#iCCA occurrence and progression
#20419
high Confidence
Subject:
NCL
(Ribosomal proteins)
→
correlates_with
→
Object:
iCCA_occurrence
(Disease phenotype)
Original: Nucleolin#correlates with#iCCA occurrence and progression
#20418
high Confidence
Subject:
ECT2
(Guanine nucleotide exchange factor)
→
promotes
→
Object:
tumor_formation
(Tumor formation)
Original: ECT2#promotes#tumor formation
#20417
high Confidence
Subject:
ECT2
(Guanine nucleotide exchange factor)
→
promotes
→
Object:
tumorigenesis
(Tumorigenesis)
Original: ECT2#promotes#tumorigenesis
#20416
high Confidence
Subject:
ECT2
(Guanine nucleotide exchange factor)
→
is_overexpressed_in
→
Object:
cancer
(Tumor)
Original: ECT2#is overexpressed in#many cancers
#20415
high Confidence
Subject:
DNA
(Nucleic acid molecules)
→
is_localized_within
→
Object:
mitotic_chromosomes
(chromosome)
Original: DNA#is localized within#nuclei and mitotic chromosomes
#20414
high Confidence
Subject:
DNA
(Nucleic acid molecules)
→
is_localized_within
→
Object:
nuclei
(Nucleus)
Original: DNA#is localized within#nuclei and mitotic chromosomes
#20413
high Confidence
Subject:
fibrillarin
(RNA methyltransferase)
→
is_responsible_for
→
Object:
rRNA_methylation
(RNA modification)
Original: Fibrillarin#is responsible for#rRNA methylation in the nucleolus
#20412
high Confidence
Subject:
PLK5
(Protein kinase)
→
leads_to
→
Object:
cell_cycle_arrest_in_G1
(Cell cycle arrest)
Original: Ectopic expression of Plk5#leads to#cell cycle arrest in G1
#20411
high Confidence
Subject:
PLK1
(Protein kinase)
→
is_involved_in
→
Object:
cell_cycle_regulation
(Cell cycle regulation)
Original: Polo-like kinases (Plk1-4)#are involved in#cell cycle regulation and DNA damage response
#20410
high Confidence
Subject:
ionizing_radiation
(Physical factors)
→
leads_to
→
Object:
p53_stabilization
(Protein stabilization)
Original: Ionizing radiation#leads to#stabilization and activation of p53
#20409
high Confidence
Subject:
ionizing_radiation
(Physical factors)
→
leads_to
→
Object:
p53_activation
(Transcription factor activation)
Original: Ionizing radiation#leads to#stabilization and activation of p53
#20408
high Confidence
Subject:
RNA_polymerase_I
(Transcriptase)
→
transcribes
→
Object:
rRNA_genes
(rRNA gene)
Original: RNA polymerase I (Pol I)#transcribes#rRNA genes in nucleolus
#20407
high Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_involved_in
→
Object:
miR-15a/16_biogenesis_primary_to_precursor
(miRNA biogenesis events)
Original: Nucleolin#is involved in#biogenesis of miR-15a/16 at primary to precursor stage
#20406
high Confidence
Subject:
nucleoli
(Nucleolus)
→
form_around
→
Object:
nucleolar_organizer_regions
(Nucleolar organizing region)
Original: Nucleoli#form around#nucleolar organizer regions (NORs)
#20405
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
regulates
→
Object:
tumorigenesis
(Tumor development process)
Original: FBL#regulates#tumorigenesis and DNA damage response
#20404
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
promotes
→
Object:
cancer_cell_resistance_to_DNA_damage
(Cellular resistance)
Original: FBL#promotes#cancer cell resistance to DNA damage and BRCA1 transcription via YBX1
#20403
high Confidence
Subject:
aberrant_ribosome_biogenesis
(Abnormal ribosome)
→
contributes_to
→
Object:
cellular_transformation
(Cell transformation)
Original: Aberrant ribosome biogenesis and epigenetic control disruption#contribute to#cellular transformation
#20402
high Confidence
Subject:
Pes1
(Ribosome biogenesis protein)
→
contains
→
Object:
BRCT_domain
(Protein domain)
Original: Pes1#contains#a BRCT-domain
#20401
high Confidence
Subject:
nucleostemin
(protein)
→
plays_essential_role_in
→
Object:
cancer_cell_proliferation
(Tumor cell proliferation)
Original: Nucleostemin#plays#an essential role in maintaining continuous proliferation of stem cells and cancer cells
#20400
high Confidence
Subject:
nucleostemin
(protein)
→
plays_essential_role_in
→
Object:
stem_cell_proliferation
(Stem cell proliferation)
Original: Nucleostemin#plays#an essential role in maintaining continuous proliferation of stem cells and cancer cells
#20399
high Confidence
Subject:
NPM1
(Protein coding genes)
→
leads_to
→
Object:
aberrant_cytoplasmic_localization
(Subcellular localization)
Original: Mutations in NPM1#lead to#aberrant cytoplasmic localization in AML
#20398
high Confidence
Subject:
NPM1
(Protein coding genes)
→
mutated_in
→
Object:
AML
(disease)
Original: Mutations in NPM1#lead to#aberrant cytoplasmic localization in AML
#20397
high Confidence
Subject:
SNORA7B
(Small nuclear RNA)
→
reduces
→
Object:
cell_proliferation
(Cellular Processes)
Original: CRISPR/Cas9 snoRNA knockout screen#revealed#SNORA65/ SNORA7A/ SNORA7B reduce proliferation in lung cancer cells
#20396
high Confidence
Subject:
SNORA7A
(Small nuclear RNA)
→
reduces
→
Object:
cell_proliferation
(Cellular Processes)
Original: CRISPR/Cas9 snoRNA knockout screen#revealed#SNORA65/ SNORA7A/ SNORA7B reduce proliferation in lung cancer cells
#20395
high Confidence
Subject:
SNORA65
(Small nuclear RNA)
→
reduces
→
Object:
cell_proliferation
(Cellular Processes)
Original: CRISPR/Cas9 snoRNA knockout screen#revealed#SNORA65/ SNORA7A/ SNORA7B reduce proliferation in lung cancer cells
#20394
high Confidence
Subject:
mTORC1
(Protein complex)
→
promotes
→
Object:
ribosome_biogenesis
(Ribosome biogenesis process)
Original: mTORC1#promotes#ribosome biogenesis
#20393
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
microRNA_processing
(miRNA processing)
Original: NCL#is involved in#microRNA processing
#20392
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
stress_response
(Stress response)
Original: NCL#is involved in#stress response
#20391
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
apoptosis_regulation
(Apoptosis regulation)
Original: NCL#is involved in#apoptosis regulation
#20390
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
angiogenesis
(Angiogenesis)
Original: NCL#is involved in#angiogenesis
#20389
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
cytokinesis
(Cell division)
Original: NCL#is involved in#cytokinesis
#20388
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
RNA_metabolism
(RNA metabolism)
Original: NCL#is involved in#DNA and RNA metabolism
#20387
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
DNA_metabolism
(DNA metabolism)
Original: NCL#is involved in#DNA and RNA metabolism
#20386
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
chromatin_stability
(Chromatin stability)
Original: NCL#is involved in#chromatin organization and stability
#20385
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_involved_in
→
Object:
chromatin_organization
(Chromatin organization)
Original: NCL#is involved in#chromatin organization and stability
#20384
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
cell_membrane
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20383
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
Cytoplasm
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20382
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
nucleoplasm
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20381
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
nucleolus
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20380
high Confidence
Subject:
RNA_Polymerase_I_inhibitor
(Small molecule inhibitors)
→
blocks
→
Object:
ribosomal_DNA_transcription
(Transcription process)
Original: Small molecule inhibitors of RNA Polymerase I#block#ribosomal DNA transcription
#20379
high Confidence
Subject:
CX5461
(Small molecule inhibitors)
→
disrupts
→
Object:
nucleolar_integrity
(Subcellular structure)
Original: CX5461#disrupts#nucleolar integrity by targeting RNAPOL1
#20378
high Confidence
Subject:
NPM
(Ribosomal proteins)
→
is_mislocalized_to
→
Object:
Cytoplasm
(Subcellular structure)
Original: Mutations#cause#aberrant cytoplasmic localization of NPM
#20377
high Confidence
Subject:
HMNA
(Nucleoprotein)
→
is_a_marker_for
→
Object:
leukemic_cells
(Tumor cells)
Original: HMNA#is a marker for#leukemic cells
#20376
high Confidence
Subject:
MYC
(Transcription Factors)
→
promotes
→
Object:
nucleolar_activity
(Nucleolar activity)
Original: MYC#promotes#nucleolar activity by enhancing rDNA and ribosomal protein transcription
#20375
high Confidence
Subject:
nucleolar_hypertrophy
(Cellular substructure phenotype)
→
is_associated_with
→
Object:
bad_prognosis_in_human_carcinomas
(Clinical Outcomes)
Original: nucleolar hypertrophy#is associated with#bad prognoses in human carcinomas
#20374
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
plays_a_role_in
→
Object:
polymerase_I_transcription
(Transcription process)
Original: Nucleolin (NCL)#plays a role in#polymerase I transcription
#20373
high Confidence
Subject:
nucleolus
(Subcellular structure)
→
plays_key_role_in
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: The nucleolus#plays#a key role in ribosome biogenesis
#20372
high Confidence
Subject:
HRPT2_mutation
(Gene mutation)
→
is_observed_in
→
Object:
parathyroid_carcinoma
(Tumor)
Original: HRPT2 mutations#are observed in#parathyroid carcinomas
#20371
high Confidence
Subject:
Deguelin
(Small molecule drugs)
→
is
→
Object:
anti_tumor_agent
(Anticancer drugs)
Original: Deguelin#is shown to be#a strong anti-tumor agent
#20370
high Confidence
Subject:
human_pancreatic_tumour_organoids
(Organoids)
→
harbor
→
Object:
TP53_mutation
(Gene mutation)
Original: human pancreatic tumour organoids#presented#multiple nucleoli and mutated KRAS and TP53
#20369
high Confidence
Subject:
human_pancreatic_tumour_organoids
(Organoids)
→
harbor
→
Object:
KRAS_mutation
(Gene mutation)
Original: human pancreatic tumour organoids#presented#multiple nucleoli and mutated KRAS and TP53
#20368
high Confidence
Subject:
nucleolus
(Nucleolus)
→
is_associated_with
→
Object:
ribosome_biosynthesis
(Ribosome biogenesis)
Original: nucleolus#is associated with#ribosome biosynthesis
#20367
high Confidence
Subject:
AOM
(Carcinogenic chemicals)
→
induces
→
Object:
ACF_in_rats
(Disease phenotype)
Original: AOM#induces#ACF in rats
#20366
high Confidence
Subject:
actinomycin_D
(Small molecule drugs)
→
inhibits
→
Object:
RNA_Polymerase_I
(Enzymes)
Original: Pharmacologic inhibition of RNA polymerase I#attenuates#signal in prostate tissue slices
#20365
high Confidence
Subject:
BMH-21
(Small molecule drugs)
→
inhibits
→
Object:
RNA_Polymerase_I
(Enzymes)
Original: Pharmacologic inhibition of RNA polymerase I#attenuates#signal in prostate tissue slices
#20364
high Confidence
Subject:
Ag-NOR
(Nucleolus-related structures)
→
is
→
Object:
prognostic_factor_in_squamous_cell_carcinoma_of_oral_mucosa
(Prognostic factors)
Original: Ag-NOR#is#a prognostic factor in squamous cell carcinoma of the oral mucosa
#20363
high Confidence
Subject:
NOP16_expression
(Gene expression)
→
was_examined_using
→
Object:
GEO_database
(Bioinformatics databases)
Original: NOP16 expression in LIHC#was examined using#various analyses/ including TCGA and GEO databases
#20362
high Confidence
Subject:
NOP16_expression
(Gene expression)
→
was_examined_using
→
Object:
TCGA_database
(Bioinformatics databases)
Original: NOP16 expression in LIHC#was examined using#various analyses/ including TCGA and GEO databases
#20361
high Confidence
Subject:
DHODH
(Enzymes)
→
inhibition_impairs
→
Object:
rDNA_transcription
(Transcription process)
Original: DHODH inhibition#impaired#rDNA transcription/ leading to nucleolar stress
#20360
high Confidence
Subject:
Actinomycin_D
(Chemotherapy drugs)
→
induces
→
Object:
reorganization_of_nucleolar_components
(Subcellular structural changes)
Original: Actinomycin D (AMD)#induces#reorganization of nucleolar components by inhibiting rRNA synthesis
#20359
high Confidence
Subject:
HPSE
(Hydrolases)
→
correlates_with
→
Object:
angiogenesis
(Angiogenesis)
Original: Heparanase#correlates with#angiogenesis
#20358
high Confidence
Subject:
HPSE
(Hydrolases)
→
correlates_with
→
Object:
cancer_metastasis
(Tumor metastasis)
Original: Heparanase#correlates with#cancer metastasis
#20357
high Confidence
Subject:
nucleolar_size
(Nuclear structure)
→
makes_a_prognosis_for
→
Object:
uveal_melanomas
(Tumor type)
Original: nucleolar size#makes a prognosis for#uveal melanomas
#20356
high Confidence
Subject:
Oxaliplatin
(Chemotherapy drugs)
→
activates
→
Object:
DNA_damage_response
(Cellular Processes)
Original: oxaliplatin#activated#DNA damage response
#20355
high Confidence
Subject:
TP53
(Transcription Factors)
→
augments
→
Object:
ribosome_production
(Ribosome biogenesis)
Original: cancer genes#augment#ribosome production
#20354
high Confidence
Subject:
MYC
(Transcription Factors)
→
augments
→
Object:
ribosome_production
(Ribosome biogenesis)
Original: cancer genes#augment#ribosome production
#20353
high Confidence
Subject:
fibrillarin
(Ribosome-associated proteins)
→
is_overexpressed_in
→
Object:
prostate_adenocarcinomas
(Tumor tissue)
Original: fibrillarin#is overexpressed in#PIN lesions and prostate adenocarcinomas
#20352
high Confidence
Subject:
fibrillarin
(Ribosome-associated proteins)
→
is_overexpressed_in
→
Object:
PIN_lesions
(Preneoplastic lesions)
Original: fibrillarin#is overexpressed in#PIN lesions and prostate adenocarcinomas
#20351
high Confidence
Subject:
adenocarcinoma_in_situ_area
(Tumor tissue)
→
shows
→
Object:
AgNOR_staining_dots
(Histological markers)
Original: Areas of adenocarcinoma in situ#show#significantly more AgNOR staining dots than normal areas
#20350
high Confidence
Subject:
ALK
(Receptor tyrosine kinases)
→
overexpression_is_associated_with
→
Object:
good_prognosis
(Prognosis)
Original: p80/ALK overexpression#is associated with#a good prognosis in t(2:5)-positive tumors
#20349
high Confidence
Subject:
Ki67_positive_tumor_nuclei
(Nuclear markers)
→
indicate
→
Object:
high_proliferative_activity
(Cellular Processes)
Original: Ki67-positive tumor nuclei#indicate#moderate to high proliferative activity
#20348
high Confidence
Subject:
CNV_based_GWAS
(Genetic analysis methods)
→
was_conducted_on
→
Object:
HCC_cases_and_controls_with_chronic_HBV_infection
(Patient population)
Original: CNV-based GWAS#was conducted on#HCC cases and controls with chronic HBV infection
#20347
high Confidence
Subject:
Ki-67-positive_nuclei
(Nuclear markers)
→
supports
→
Object:
diagnosis_of_parathyroid_carcinoma
(Disease phenotype)
Original: Ki-67-positive nuclei#support#diagnosis of parathyroid carcinoma
#20346
high Confidence
Subject:
Ki-67
(Protein markers)
→
is_a_marker_of
→
Object:
malignancy_in_parathyroid_tumors
(Disease phenotype)
Original: Ki-67#is#a valuable marker of malignancy in parathyroid tumors
#20345
high Confidence
Subject:
Ki-67
(Cell proliferation markers)
→
is_useful_for
→
Object:
diagnostic_malignant_parathyroid_tumors
(Diagnosis of malignant parathyroid tumors)
Original: Ki-67 immunostaining#is useful for#diagnosing malignant parathyroid tumors
#20344
high Confidence
Subject:
NCL
(Nucleolin)
→
translocates_to_surface_during
→
Object:
carcinogenesis
(Tumor development process)
Original: translocation of nucleolin to cell surface#occurs during#carcinogenesis
#20343
high Confidence
Subject:
NCL
(Nucleolin)
→
is_present_on
→
Object:
surface_of_gastric_cancer_cells
(Cell subtype)
Original: nucleolin#is present on#surface of gastric cancer cell lines
#20342
high Confidence
Subject:
NCL
(Nucleolin)
→
is
→
Object:
major_component_of_silver-stained_nucleolar_organizer_region
(Molecular complex)
Original: nucleolin#is#a major component of silver-stained nucleolar organizer region and a marker of cancer
#20341
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
PAX8
(Transcription Factors)
Original: tumors#are variably positive for#EMA/ CK7/ CA9/ PAX8
#20340
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CA9
(Carbonic anhydrase)
Original: tumors#are variably positive for#EMA/ CK7/ CA9/ PAX8
#20339
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CK7
(Cytokeratin)
Original: tumors#are variably positive for#EMA/ CK7/ CA9/ PAX8
#20338
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
EMA
(Epithelial membrane antigen)
Original: tumors#are variably positive for#EMA/ CK7/ CA9/ PAX8
#20337
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
Mitochondria
(Mitochondria)
Original: tumors#are diffusely positive for#vimentin/ CD10/ RCC/ CAM5.2/ P504s/ mitochondria
#20336
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
P504s
(Enzymes)
Original: tumors#are diffusely positive for#vimentin/ CD10/ RCC/ CAM5.2/ P504s/ mitochondria
#20335
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CAM5.2
(Cytokeratin)
Original: tumors#are diffusely positive for#vimentin/ CD10/ RCC/ CAM5.2/ P504s/ mitochondria
#20334
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
RCC
(Renal cell carcinoma associated antigen)
Original: tumors#are diffusely positive for#vimentin/ CD10/ RCC/ CAM5.2/ P504s/ mitochondria
#20333
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD10
(Cell surface proteins)
Original: tumors#are diffusely positive for#vimentin/ CD10/ RCC/ CAM5.2/ P504s/ mitochondria
#20332
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
vimentin
(Intermediate filament protein)
Original: tumors#are diffusely positive for#vimentin/ CD10/ RCC/ CAM5.2/ P504s/ mitochondria
#20331
high Confidence
Subject:
mitotic_count
(Pathological indicators)
→
is_marker_for
→
Object:
tumor_grade
(Tumor grade)
Original: Mitotic count#is#the most important marker for tumor grade
#20330
high Confidence
Subject:
MKI67
(Cell proliferation-related proteins)
→
is_expressed_in
→
Object:
advanced_gastric_cancer_patients
(patient)
Original: Ki-67 antigen expression#was studied in#advanced gastric cancer patients
#20329
high Confidence
Subject:
high_nucleolus_score
(Pathological scoring)
→
correlates_with
→
Object:
HER2_status
(Molecular phenotype)
Original: High nucleolus score#correlates with#estrogen receptor negativity/ progesterone receptor negativity/ high Ki-67/ triple negative/ and HER-2 status
#20328
high Confidence
Subject:
high_nucleolus_score
(Pathological scoring)
→
correlates_with
→
Object:
triple_negative_status
(Molecular typing)
Original: High nucleolus score#correlates with#estrogen receptor negativity/ progesterone receptor negativity/ high Ki-67/ triple negative/ and HER-2 status
#20327
high Confidence
Subject:
high_nucleolus_score
(Pathological scoring)
→
correlates_with
→
Object:
high_Ki-67
(Proliferation markers)
Original: High nucleolus score#correlates with#estrogen receptor negativity/ progesterone receptor negativity/ high Ki-67/ triple negative/ and HER-2 status
#20326
high Confidence
Subject:
high_nucleolus_score
(Pathological scoring)
→
correlates_with
→
Object:
progesterone_receptor_negativity
(Molecular phenotype)
Original: High nucleolus score#correlates with#estrogen receptor negativity/ progesterone receptor negativity/ high Ki-67/ triple negative/ and HER-2 status
#20325
high Confidence
Subject:
high_nucleolus_score
(Pathological scoring)
→
correlates_with
→
Object:
estrogen_receptor_negativity
(Molecular phenotype)
Original: High nucleolus score#correlates with#estrogen receptor negativity/ progesterone receptor negativity/ high Ki-67/ triple negative/ and HER-2 status
#20324
high Confidence
Subject:
non-neoplastic_luminal_epithelium
(Normal luminal epithelium)
→
shows
→
Object:
lower_signal
(molecular signaling)
Original: Precursor lesion (high-grade PIN) and invasive adenocarcinoma lesions#showed#marked increase in signal compared to non-neoplastic luminal epithelium
#20323
high Confidence
Subject:
invasive_adenocarcinoma
(Adenocarcinoma)
→
shows
→
Object:
increased_signal
(molecular signaling)
Original: Precursor lesion (high-grade PIN) and invasive adenocarcinoma lesions#showed#marked increase in signal compared to non-neoplastic luminal epithelium
#20322
high Confidence
Subject:
high-grade_PIN
(Precursor lesions)
→
shows
→
Object:
increased_signal
(molecular signaling)
Original: Precursor lesion (high-grade PIN) and invasive adenocarcinoma lesions#showed#marked increase in signal compared to non-neoplastic luminal epithelium
#20321
high Confidence
Subject:
CISH_assay
(In situ hybridization assay)
→
detects
→
Object:
expression_of_5'_ETS_of_45S_rRNA_precursor
(45S rRNA precursor 5' external transcribed spacer expression)
Original: CISH assay#detects#expression of 5' external transcribed spacer (ETS) of 45S rRNA precursor
#20320
high Confidence
Subject:
AgNOR
(Nucleolar organizer region-associated silver staining)
→
are_demonstrated_by
→
Object:
one-step_silver_technique
(Silver staining technique)
Original: AgNORs#are demonstrated by#a one-step silver technique
#20319
high Confidence
Subject:
cytological_examination
(Cytology)
→
helps_in
→
Object:
early_detection_of_malignant_oral_lesions
(Early detection of oral malignant lesions)
Original: Cytological examination#helps in#early detection of malignant oral lesions
#20318
high Confidence
Subject:
microinvasive_carcinoma
(Cancer Type)
→
invades
→
Object:
connective_tissue
(Organization Type)
Original: Histopathological examination#shows#microinvasive carcinoma invading connective tissue
#20317
high Confidence
Subject:
nucleolar_organizer_region_proteins
(Nucleolar Organizing Region Protein)
→
are_markers_of
→
Object:
proliferation
(Cell proliferation)
Original: Nucleolar organizer region proteins#are markers of#DNA transcription and proliferation
#20316
high Confidence
Subject:
nucleolar_organizer_region_proteins
(Nucleolar Organizing Region Protein)
→
are_markers_of
→
Object:
DNA_transcription
(DNA transcription)
Original: Nucleolar organizer region proteins#are markers of#DNA transcription and proliferation
#20315
high Confidence
Subject:
AgNORs
(Nucleolar Organizing Region Marker)
→
is_used_to_assess
→
Object:
tumor_proliferation
(Tumor proliferation)
Original: PCNA and AgNOR#are used to assess#salivary gland tumor proliferation
#20314
high Confidence
Subject:
PCNA
(Proliferation-related proteins)
→
is_used_to_assess
→
Object:
tumor_proliferation
(Tumor proliferation)
Original: PCNA and AgNOR#are used to assess#salivary gland tumor proliferation
#20313
high Confidence
Subject:
AgNOR_counts
(Nucleolar organizer region-associated protein count)
→
indicates
→
Object:
proliferative_activity_of_cancer_cells
(Tumor cell proliferation activity)
Original: Proliferative activity of cancer cells#is indicated by#AgNOR counts in gastric adenocarcinoma
#20312
high Confidence
Subject:
SNORA68_expression
(Small nuclear RNA expression)
→
is_associated_with
→
Object:
shorter_disease-free_survival
(Shortened disease-free survival)
Original: SNORA68 expression#is associated with#shorter disease-free survival
#20311
high Confidence
Subject:
SNORA23_expression
(Noncoding RNA)
→
is_lower_in
→
Object:
non-tumor_tissue
(Normal tissue)
Original: SNORA23 expression#is increased in#human PDAC tissues compared with non-tumor tissues
#20310
high Confidence
Subject:
SNORA23_expression
(Noncoding RNA)
→
is_increased_in
→
Object:
human_PDAC_tissue
(Disease Organization)
Original: SNORA23 expression#is increased in#human PDAC tissues compared with non-tumor tissues
#20309
high Confidence
Subject:
SNORA23
(Noncoding RNA)
→
was_not_detected_in
→
Object:
non-tumor_pancreatic_tissue
(Normal tissue)
Original: SNORA23#was detected in#human PDAC specimens but not in non-tumor pancreatic tissue
#20308
high Confidence
Subject:
SNORA23
(Noncoding RNA)
→
was_detected_in
→
Object:
human_PDAC_specimen
(Disease Organization)
Original: SNORA23#was detected in#human PDAC specimens but not in non-tumor pancreatic tissue
#20307
high Confidence
Subject:
NORs
(Nucleolar structure)
→
are_associated_with
→
Object:
proliferative_activity
(Cellular Processes)
Original: NORs#are associated with#proliferative activity of tumors
#20306
high Confidence
Subject:
neuroendocrine_tumors
(Tumor diseases)
→
are_primarily_found_in
→
Object:
lungs
(organ)
Original: neuroendocrine tumors#are primarily found in#lungs
#20305
high Confidence
Subject:
tumor_cell
(Tumor cells)
→
exhibits
→
Object:
nuclear_atypia
(Nuclear abnormalities)
Original: Tumor cells#exhibit#nuclear atypia/ indentations nuclei/ and prominent nucleoli
#20304
high Confidence
Subject:
UVPC
(Disease subtype)
→
exhibits
→
Object:
pseudoinclusions
(Nuclear inclusions)
Original: UVPC specimens#exhibit#larger nuclei/ higher N/C ratio/ larger nucleoli/ and nuclear grooves and pseudoinclusions
#20303
high Confidence
Subject:
UVPC
(Disease subtype)
→
exhibits
→
Object:
nuclear_grooves
(Nuclear morphology)
Original: UVPC specimens#exhibit#larger nuclei/ higher N/C ratio/ larger nucleoli/ and nuclear grooves and pseudoinclusions
#20302
high Confidence
Subject:
UVPC
(Disease subtype)
→
exhibits
→
Object:
larger_nucleoli
(Cell nucleolus characteristics)
Original: UVPC specimens#exhibit#larger nuclei/ higher N/C ratio/ larger nucleoli/ and nuclear grooves and pseudoinclusions
#20301
high Confidence
Subject:
UVPC
(Disease subtype)
→
exhibits
→
Object:
higher_NC_ratio
(Nuclear-cytoplasmic ratio)
Original: UVPC specimens#exhibit#larger nuclei/ higher N/C ratio/ larger nucleoli/ and nuclear grooves and pseudoinclusions
#20300
high Confidence
Subject:
UVPC
(Disease subtype)
→
exhibits
→
Object:
larger_nuclei
(Nuclear characteristics)
Original: UVPC specimens#exhibit#larger nuclei/ higher N/C ratio/ larger nucleoli/ and nuclear grooves and pseudoinclusions
#20299
high Confidence
Subject:
T-cell_receptor_gamma_gene
(TCR Gene)
→
shows
→
Object:
monoclonal_rearrangement
(Gene rearrangement)
Original: Molecular evaluation#demonstrated#monoclonal rearrangement of the T-cell receptor gamma gene
#20298
high Confidence
Subject:
Molecular_detection
(Diagnostic Tests)
→
is_used_in
→
Object:
diagnosis_of_fumarate_hydratase-deficient_uterine_leiomyomas
(Disease diagnosis)
Original: Clinicopathological/ immunohistochemistry/ and molecular detection#are used in#diagnosis of fumarate hydratase-deficient uterine leiomyomas
#20297
high Confidence
Subject:
Immunohistochemistry_detection
(Diagnostic Tests)
→
is_used_in
→
Object:
diagnosis_of_fumarate_hydratase-deficient_uterine_leiomyomas
(Disease diagnosis)
Original: Clinicopathological/ immunohistochemistry/ and molecular detection#are used in#diagnosis of fumarate hydratase-deficient uterine leiomyomas
#20296
high Confidence
Subject:
Clinicopathological_detection
(Diagnostic Tests)
→
is_used_in
→
Object:
diagnosis_of_fumarate_hydratase-deficient_uterine_leiomyomas
(Disease diagnosis)
Original: Clinicopathological/ immunohistochemistry/ and molecular detection#are used in#diagnosis of fumarate hydratase-deficient uterine leiomyomas
#20295
high Confidence
Subject:
specimens
(Biological samples)
→
were_retrieved_from
→
Object:
surgical_pathology_files
(Clinical Data)
Original: 1338 specimens#were retrieved from#surgical pathology files
#20294
high Confidence
Subject:
MDM2
(Ubiquitin ligase)
→
abrogates
→
Object:
p53-mediated_G1_arrest
(Molecular modification regulation)
Original: MDM2 oncoprotein#abrogates#p53-mediated G1 arrest and apoptosis
#20293
high Confidence
Subject:
Helicobacter_pylori_infection
(Pathogenic factors)
→
acts_as_cofactor_in
→
Object:
gastric_carcinogenesis
(Tumor development process)
Original: H. pylori infection#plays a role as#a co-factor in gastric carcinogenesis
#20292
high Confidence
Subject:
AMACR
(Enzymes)
→
is_equivalent_to
→
Object:
p63_AMACR_cocktail
(Immunohistochemistry reagents)
Original: p63/AMACR cocktail#is equivalent to#each antibody separately for diagnosing prostatic carcinoma
#20291
high Confidence
Subject:
p63
(Transcription Factors)
→
is_equivalent_to
→
Object:
p63_AMACR_cocktail
(Immunohistochemistry reagents)
Original: p63/AMACR cocktail#is equivalent to#each antibody separately for diagnosing prostatic carcinoma
#20290
high Confidence
Subject:
p63
(Transcription Factors)
→
is_equivalent_to
→
Object:
AMACR
(Enzymes)
Original: p63/AMACR cocktail#is equivalent to#each antibody separately for diagnosing prostatic carcinoma
#20289
high Confidence
Subject:
AgNORs
(Nucleolar Organizing Region Marker)
→
differentiations
→
Object:
ameloblastoma
(Tumor type)
Original: Argyrophilic nucleolar organizing regions (AgNORs)#differentiate#ameloblastic carcinoma from ameloblastoma
#20288
high Confidence
Subject:
AgNORs
(Nucleolar Organizing Region Marker)
→
differentiations
→
Object:
ameloblastic_carcinoma
(Tumor type)
Original: Argyrophilic nucleolar organizing regions (AgNORs)#differentiate#ameloblastic carcinoma from ameloblastoma
#20287
high Confidence
Subject:
cytopathologic_cellular_features
(Cell morphology)
→
correlated_with
→
Object:
high_grade_diagnosis
(High-grade diagnosis)
Original: Cytopathologic cellular features#correlated with#a high-grade diagnosis
#20286
high Confidence
Subject:
TP53
(Transcription Factors)
→
is_positive_in
→
Object:
tumor
(Tumor tissue)
Original: Tumors#were diffusely positive for#p53 and showed high Ki-67 proliferation index
#20285
high Confidence
Subject:
Silver_staining_of_AgNORs
(Dyeing technology)
→
is_used_as
→
Object:
Marker_of_malignancy
(Molecular markers)
Original: Silver staining of AgNORs#is widely used as#a marker of malignancy in tumor pathology
#20284
high Confidence
Subject:
Neuroendocrine tumors
(Tumor type)
→
showed
→
Object:
Ki-67_index_5%
(Proliferation markers)
Original: Neuroendocrine tumors#showed#cells arranged in cords or nests with Ki-67 index of 5% (G2 neuroendocrine tumor) and 80% (small-cell neuroendocrine carcinoma)
#20283
high Confidence
Subject:
IGCN
(Histopathological entities)
→
is_recognized_with
→
Object:
abundant_cytoplasm
(Cell morphology)
Original: IGCN#is recognized with#large cells/ hyperchromatic nuclei/ nucleoli/ and abundant cytoplasm
#20282
high Confidence
Subject:
IGCN
(Histopathological entities)
→
is_recognized_with
→
Object:
nucleoli
(Cell morphology)
Original: IGCN#is recognized with#large cells/ hyperchromatic nuclei/ nucleoli/ and abundant cytoplasm
#20281
high Confidence
Subject:
IGCN
(Histopathological entities)
→
is_recognized_with
→
Object:
hyperchromatic_nuclei
(Cell morphology)
Original: IGCN#is recognized with#large cells/ hyperchromatic nuclei/ nucleoli/ and abundant cytoplasm
#20280
high Confidence
Subject:
IGCN
(Histopathological entities)
→
is_recognized_with
→
Object:
large_cells
(Cell morphology)
Original: IGCN#is recognized with#large cells/ hyperchromatic nuclei/ nucleoli/ and abundant cytoplasm
#20279
high Confidence
Subject:
PDGFRA
(Protein coding genes)
→
showed_no_mutations
→
Object:
not_specified
(not_specified)
Original: Molecular genetic analysis#showed#no mutations of KIT and PDGFRA genes
#20278
high Confidence
Subject:
KIT
(Protein coding genes)
→
showed_no_mutations
→
Object:
not_specified
(not_specified)
Original: Molecular genetic analysis#showed#no mutations of KIT and PDGFRA genes
#20277
high Confidence
Subject:
anaplastic_medulloblastoma
(Tumor type)
→
differentially_diagnosed_from
→
Object:
large_cell_lymphoma
(Tumor type)
Original: Differential diagnosis of anaplastic medulloblastoma#includes#metastatic carcinomas and large cell lymphoma
#20276
high Confidence
Subject:
anaplastic_medulloblastoma
(Tumor type)
→
differentially_diagnosed_from
→
Object:
metastatic_carcinoma
(Tumor type)
Original: Differential diagnosis of anaplastic medulloblastoma#includes#metastatic carcinomas and large cell lymphoma
#20275
high Confidence
Subject:
duodenal_tumors
(Tumor)
→
were_pointed_out_by
→
Object:
upper_gastrointestinal_endoscopy
(Diagnostic techniques)
Original: multiple duodenal tumors#were pointed out by#upper gastrointestinal endoscopy
#20274
high Confidence
Subject:
imatinib_mesylate
(Targeted drugs)
→
induces
→
Object:
partial_response_with_tumor_size_reduction
(Response to treatment)
Original: Neoadjuvant imatinib mesylate treatment#revealed#a partial response with tumor size reduction
#20273
high Confidence
Subject:
NUT
(Protein coding genes)
→
shows
→
Object:
strong_positivity_in_IHC
(Immunohistochemical expression)
Original: Immunohistochemical staining#demonstrated#strong positivity for vimentin and NUT
#20272
high Confidence
Subject:
cytopathological_findings
(Pathological characteristics)
→
correlate_with
→
Object:
histopathological_findings
(Pathological characteristics)
Original: Cytopathological findings#correlate with#histopathological findings in uterine MMMT
#20271
high Confidence
Subject:
B-cell_prolymphocytic_leukemia
(B-cell prolymphocytic leukemia)
→
have
→
Object:
complex_karyotype_including_chromosomal_translocation_8_14_q24_q32
(Chromosomal translocation)
Original: B-cell prolymphocytic leukemia#had#complex karyotype including chromosomal translocation (8;14) (q24;q32)
#20270
high Confidence
Subject:
laminin
(Extracellular matrix proteins)
→
is_not_detected_in
→
Object:
cells
(Tumor cells)
Original: synthesis of human chorionic gonadotropin/ alpha-fetoprotein/ and laminin#is not detected in#cells
#20269
high Confidence
Subject:
alpha-fetoprotein
(Glycoprotein)
→
is_not_detected_in
→
Object:
cells
(Tumor cells)
Original: synthesis of human chorionic gonadotropin/ alpha-fetoprotein/ and laminin#is not detected in#cells
#20268
high Confidence
Subject:
human chorionic gonadotropin
(Glycoprotein hormones)
→
is_not_detected_in
→
Object:
cells
(Tumor cells)
Original: synthesis of human chorionic gonadotropin/ alpha-fetoprotein/ and laminin#is not detected in#cells
#20267
high Confidence
Subject:
lesional cells
(Tumor cells)
→
are_negative_for
→
Object:
prostate-specific acid phosphatase
(Protein markers)
Original: lesional cells#were negative for#prostate-specific antigen and prostate-specific acid phosphatase
#20266
high Confidence
Subject:
lesional cells
(Tumor cells)
→
are_negative_for
→
Object:
prostate-specific antigen
(Protein markers)
Original: lesional cells#were negative for#prostate-specific antigen and prostate-specific acid phosphatase
#20265
high Confidence
Subject:
Laparoscopic_biopsy
(Tissue sampling techniques)
→
revealed
→
Object:
angiosarcoma_in_abdominal_mass
(Tumor)
Original: Laparoscopic biopsies#revealed#angiosarcoma in liver/abdominal masses
#20264
high Confidence
Subject:
Laparoscopic_biopsy
(Tissue sampling techniques)
→
revealed
→
Object:
angiosarcoma_in_liver
(Tumor)
Original: Laparoscopic biopsies#revealed#angiosarcoma in liver/abdominal masses
#20263
high Confidence
Subject:
metastatic_tumor
(Tumor type)
→
shows
→
Object:
metastasis
(Tumor progression)
Original: Tumor#presented with#metastasis and hyperchromatic nuclei
#20262
high Confidence
Subject:
computed_tomography_scan
(Imaging tests)
→
confirms
→
Object:
3-cm_nodule_in_right_parietal_lobe_of_brain
(Image Discovery)
Original: Computed tomography scan#confirmed#a 3-cm nodule in the right parietal lobe of the brain
#20261
high Confidence
Subject:
gene_rearrangement_study
(Gene rearrangement analysis)
→
confirms
→
Object:
cytologic_diagnosis
(Cytological diagnosis)
Original: Histology and gene rearrangement studies#confirmed#cytologic diagnosis
#20260
high Confidence
Subject:
diagnosis
(Diagnosis conclusion)
→
was
→
Object:
poorly_differentiated_eccrine_adenocarcinoma
(Tumor type)
Original: Diagnosis#was#a poorly differentiated eccrine adenocarcinoma
#20259
high Confidence
Subject:
biopsy
(Histological procedures)
→
was_done_to_make
→
Object:
definitive_diagnosis
(Diagnosis conclusion)
Original: Biopsy#was done to make#a definitive diagnosis
#20258
high Confidence
Subject:
HepPar1
(Liver-specific antigen)
→
shows_positivity_in
→
Object:
Immunohistochemical_stains
(Detection Methods)
Original: Immunohistochemical stains#showed#positivity for E-Cadherin/ Carcinoembryonic Antigen/ and HepPar1
#20257
high Confidence
Subject:
Carcinoembryonic_Antigen
(Tumor markers)
→
shows_positivity_in
→
Object:
Immunohistochemical_stains
(Detection Methods)
Original: Immunohistochemical stains#showed#positivity for E-Cadherin/ Carcinoembryonic Antigen/ and HepPar1
#20256
high Confidence
Subject:
E-Cadherin
(Cell adhesion molecules)
→
shows_positivity_in
→
Object:
Immunohistochemical_stains
(Detection Methods)
Original: Immunohistochemical stains#showed#positivity for E-Cadherin/ Carcinoembryonic Antigen/ and HepPar1
#20255
high Confidence
Subject:
Metastatic_breast_carcinoma_to_thyroid
(Tumor)
→
mimics
→
Object:
primary_thyroid_carcinoma_on_FNA
(Tumor)
Original: Metastatic breast carcinoma to the thyroid#mimics#primary thyroid carcinoma on FNA
#20254
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
display
→
Object:
abundant_eosinophilic_cytoplasm_with_fine_granules
(Cytoplasmic morphology)
Original: Neoplastic cells#had#large/ irregular/ oval nuclei; prominent eosinophilic nucleoli; and abundant eosinophilic cytoplasm with fine granules
#20253
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
display
→
Object:
prominent_eosinophilic_nucleoli
(Cell nucleolus morphology)
Original: Neoplastic cells#had#large/ irregular/ oval nuclei; prominent eosinophilic nucleoli; and abundant eosinophilic cytoplasm with fine granules
#20252
high Confidence
Subject:
Neoplastic_cells
(Tumor cells)
→
display
→
Object:
large_irregular_oval_nuclei
(Nuclear morphology)
Original: Neoplastic cells#had#large/ irregular/ oval nuclei; prominent eosinophilic nucleoli; and abundant eosinophilic cytoplasm with fine granules
#20251
high Confidence
Subject:
immunohistochemical_staining
(Detection Technology)
→
revealed
→
Object:
no_reactivity_for_TTF-1
(Protein expression)
Original: immunohistochemical staining#revealed#strong expression of GATA3 and mammaglobin with no reactivity for thyroglobulin or TTF-1
#20250
high Confidence
Subject:
immunohistochemical_staining
(Detection Technology)
→
revealed
→
Object:
no_reactivity_for_thyroglobulin
(Protein expression)
Original: immunohistochemical staining#revealed#strong expression of GATA3 and mammaglobin with no reactivity for thyroglobulin or TTF-1
#20249
high Confidence
Subject:
immunohistochemical_staining
(Detection Technology)
→
revealed
→
Object:
strong_expression_of_mammaglobin
(Protein expression)
Original: immunohistochemical staining#revealed#strong expression of GATA3 and mammaglobin with no reactivity for thyroglobulin or TTF-1
#20248
high Confidence
Subject:
immunohistochemical_staining
(Detection Technology)
→
revealed
→
Object:
strong_expression_of_GATA3
(Protein expression)
Original: immunohistochemical staining#revealed#strong expression of GATA3 and mammaglobin with no reactivity for thyroglobulin or TTF-1
#20247
high Confidence
Subject:
Cytologic_diagnosis
(Diagnosis conclusion)
→
was
→
Object:
LCNEC
(Neoplastic diseases)
Original: Original cytologic diagnosis#was#LCNEC in nine cases
#20246
high Confidence
Subject:
color_Doppler_ultrasonography
(Medical imaging technology)
→
confirms
→
Object:
tumor
(Tumor)
Original: All tumors#were clinically suspected and confirmed by#arteriography or color Doppler ultrasonography
#20245
high Confidence
Subject:
arteriography
(Medical imaging technology)
→
confirms
→
Object:
tumor
(Tumor)
Original: All tumors#were clinically suspected and confirmed by#arteriography or color Doppler ultrasonography
#20244
high Confidence
Subject:
malignant_rhabdoid_tumors_of_the_spine
(Tumor)
→
are_classified_as
→
Object:
rare_pediatric_neoplasms
(disease)
Original: Malignant rhabdoid tumors of the spine#are classified as#rare pediatric neoplasms
#20243
high Confidence
Subject:
this_tumour
(Tumor)
→
is_classified_as
→
Object:
undifferentiated_malignant_lymphoma
(disease)
Original: This tumour#is classified as#an undifferentiated malignant lymphoma
#20242
high Confidence
Subject:
alkaline_phosphatase_activity
(Enzyme activity)
→
distinguishes
→
Object:
Telangiectatic_osteosarcoma
(Tumor diseases)
Original: alkaline phosphatase activity#distinguishes#TOS from other osteolytic bone tumors
#20241
high Confidence
Subject:
FNA_biopsy
(Cytological detection technology)
→
demonstrates_value_in
→
Object:
osteosarcoma_diagnosis_in_adrenal_gland
(Diagnosis conclusion)
Original: FNA biopsy combined with immunocytochemistry#demonstrated value in#diagnosing osteosarcoma from an unusual location such as the adrenal gland
#20240
high Confidence
Subject:
osteosarcoma
(Tumor diseases)
→
is_primary_malignant_tumor_of
→
Object:
long_bones
(Anatomical location)
Original: Osteosarcoma#a primary malignant tumor of#the long bones/ frequently metastasizes to the lungs
#20239
high Confidence
Subject:
FH_gene_abnormalities
(Genetic abnormalities)
→
showed
→
Object:
positive_staining_for_2SC
(Molecular markers)
Original: Tumors with FH gene abnormalities#showed#positive staining for 2SC
#20238
high Confidence
Subject:
Papillary-cystic_neoplasm
(Tumor type)
→
is_located_in
→
Object:
Pancreas
(organ)
Original: Papillary-cystic neoplasm#is located in#the pancreas
#20237
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
are_positive_for
→
Object:
AMACR
(Enzymes)
Original: Neoplastic cells#are positive for#AMACR
#20236
high Confidence
Subject:
Children's Cancer Group ALL protocols
(Treatment options)
→
treats
→
Object:
Acute lymphoblastic leukemia
(disease)
Original: Both patients#were treated with#Children's Cancer Group ALL protocols
#20235
high Confidence
Subject:
TBrC
(Tumor subtype)
→
has_characteristic
→
Object:
higher_tumor_grade
(Tumor grade)
Original: TNBrCa#have characteristic histologic features including#higher tumor grade/ pushing tumor border/ geographic necrosis/ syncytial growth pattern
#20234
high Confidence
Subject:
VIN_3
(Disease classification)
→
is_defined_by
→
Object:
abnormal_mitotic_figures_throughout_epithelium
(Abnormal cell division phase)
Original: VIN 3#is defined by#nuclear abnormalities and abnormal mitotic figures throughout most or all of the epithelium
#20233
high Confidence
Subject:
VIN_3
(Disease classification)
→
is_defined_by
→
Object:
nuclear_abnormalities
(Nuclear abnormalities)
Original: VIN 3#is defined by#nuclear abnormalities and abnormal mitotic figures throughout most or all of the epithelium
#20232
high Confidence
Subject:
VIN_2
(Disease classification)
→
is_defined_by
→
Object:
mitotic_figures_confined_to_basal_half_of_epithelium
(Cell division phase positioning)
Original: VIN 2#is defined by#nuclear atypia and mitotic figures confined to the basal half of the epithelium
#20231
high Confidence
Subject:
VIN_2
(Disease classification)
→
is_defined_by
→
Object:
nuclear_atypia
(Nuclear abnormalities)
Original: VIN 2#is defined by#nuclear atypia and mitotic figures confined to the basal half of the epithelium
#20230
high Confidence
Subject:
refractile_keratin_clumps
(Cell morphology)
→
provides_clue_for
→
Object:
diagnosis_of_pilomatrixoma
(Disease diagnosis)
Original: prominent nucleoli in basaloid cells and refractile keratin clumps#were useful clues in#diagnosis of pilomatrixoma
#20229
high Confidence
Subject:
prominent_nucleoli_in_basaloid_cells
(Cell morphology)
→
provides_clue_for
→
Object:
diagnosis_of_pilomatrixoma
(Disease diagnosis)
Original: prominent nucleoli in basaloid cells and refractile keratin clumps#were useful clues in#diagnosis of pilomatrixoma
#20228
high Confidence
Subject:
high_grade_endometrial_stromal_sarcoma
(Tumor type)
→
should_be_considered_in
→
Object:
differential_diagnosis_of_spindle_tumor_cells
(Diagnostic Process)
Original: High-grade endometrial stromal sarcoma#should be considered in#the differential diagnosis of round-to-short spindle tumor cells and taper-shaped tumor cells
#20227
high Confidence
Subject:
Polymorphous_adenocarcinoma
(Adenocarcinoma)
→
shows
→
Object:
alterations_in_polymorphous_adenocarcinoma-associated_gene
(Genomic variation)
Original: 20 cases of polymorphous adenocarcinoma#exhibited#alterations in at least one polymorphous adenocarcinoma-associated gene
#20226
high Confidence
Subject:
Tumor
(Tumor tissue)
→
showed_immunoreactivity_with
→
Object:
cytokeratin_8/18
(Cell markers)
Original: Tumor#showed immunoreactivity with#cytokeratin 8/18/ cytokeratin 18/ cytokeratin 19/ vimentin
#20225
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
were_positive_for
→
Object:
cytokeratin_19
(Cell markers)
Original: Tumor cells#were positive for#cytokeratin 19 but negative for glypican 3
#20224
high Confidence
Subject:
cytological_specimens
(Cytology specimens)
→
are_analyzed_with
→
Object:
ROSE
(Digital health technologies)
Original: cytological specimens#are analyzed with#ROSE in lung cancer patients
#20223
high Confidence
Subject:
tumor
(Tumor)
→
contains
→
Object:
TERT_promoter_rearrangement
(Gene rearrangement)
Original: Tumor#contains#a novel telomerase reverse transcriptase promoter rearrangement
#20222
high Confidence
Subject:
carcinoid_tumors
(Tumor type)
→
are_limited_to
→
Object:
urinary_bladder
(organ)
Original: Carcinoid tumors#are limited to#urinary bladder
#20221
high Confidence
Subject:
diagnosis
(Diagnosis conclusion)
→
is
→
Object:
anaplastic_oligodendroglioma
(Tumor type)
Original: diagnosis#is#anaplastic oligodendroglioma
#20220
high Confidence
Subject:
severe_nuclear_atypia
(Abnormal nuclear morphology)
→
is_diagnosed_as
→
Object:
carcinoma_in_situ
(Tumor type)
Original: Severe nuclear atypia in the mucosa#is diagnosed as#carcinoma in situ (CIS)
#20219
high Confidence
Subject:
AgNOR_stained_nucleoli
(Nucleolus)
→
can_be_captured_and_measured_by
→
Object:
automated_image_analyzer
(Imaging technology)
Original: AgNOR-stained nucleoli#can be captured and measured by#an automated image analyzer
#20218
high Confidence
Subject:
abnormal_cells
(Tumor cell type)
→
have
→
Object:
chromosomal_translocation_t(2;5)(p23;q35)
(Chromosomal mutations)
Original: Abnormal cells#have#a characteristic chromosomal translocation t(2;5)(p23;q35)
#20217
high Confidence
Subject:
malignant_cells
(Tumor cells)
→
showed_positive_staining_with
→
Object:
ALK
(Protein markers)
Original: Malignant cells#showed#positive staining with CD30/ ALK/ epithelial membrane antigen/ and beta-HCG
#20216
high Confidence
Subject:
malignant_cells
(Tumor cells)
→
showed_positive_staining_with
→
Object:
CD30
(Protein markers)
Original: Malignant cells#showed#positive staining with CD30/ ALK/ epithelial membrane antigen/ and beta-HCG
#20215
high Confidence
Subject:
Histological_assessment
(Histological evaluation)
→
diagnoses
→
Object:
Hurthle_cell_carcinoma
(Tumor type)
Original: Histological assessment#diagnosed#papillary carcinoma/ Hurthle cell carcinoma/ and multinodular goitre with degenerate changes
#20214
high Confidence
Subject:
Histological_assessment
(Histological evaluation)
→
diagnoses
→
Object:
papillary_carcinoma
(Tumor type)
Original: Histological assessment#diagnosed#papillary carcinoma/ Hurthle cell carcinoma/ and multinodular goitre with degenerate changes
#20213
high Confidence
Subject:
TP53
(protein)
→
was_detected_by
→
Object:
Immunohistochemistry
(Detection Methods)
Original: Expression of Ki67/ p53/ CEA/ CDX/ and CK7#was detected by#immunohistochemistry
#20212
high Confidence
Subject:
KI67
(protein)
→
was_detected_by
→
Object:
Immunohistochemistry
(Detection Methods)
Original: Expression of Ki67/ p53/ CEA/ CDX/ and CK7#was detected by#immunohistochemistry
#20211
high Confidence
Subject:
PSA
(Protein markers)
→
is_localized_in
→
Object:
prostatic_carcinoma
(Tumor diseases)
Original: We#investigated#localizations of PSA in prostatic carcinomas
#20210
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
CD3
(T cell markers)
Original: tumor cells#are#negative for CD3
#20209
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
contain
→
Object:
visible_nucleoli
(Cell morphology)
Original: tumor cells#contain#visible nucleoli
#20208
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
exhibit
→
Object:
significant_atypia
(Cell morphology)
Original: tumor cells#exhibit#large nuclei/ prominent nucleoli/ and significant atypia
#20207
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
exhibit
→
Object:
prominent_nucleoli
(Cell morphology)
Original: tumor cells#exhibit#large nuclei/ prominent nucleoli/ and significant atypia
#20206
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
exhibit
→
Object:
large_nuclei
(Cell morphology)
Original: tumor cells#exhibit#large nuclei/ prominent nucleoli/ and significant atypia
#20205
high Confidence
Subject:
Immunoblast_cells
(Immune cells)
→
exhibit
→
Object:
irregular_nucleoli
(Cell morphology)
Original: local lymph follicles#exhibit#peritumoral lymphocyte accumulation and immunoblast cells with large vesicular nuclei and irregular nucleoli
#20204
high Confidence
Subject:
Immunoblast_cells
(Immune cells)
→
exhibit
→
Object:
large_vesicular_nuclei
(Cell morphology)
Original: local lymph follicles#exhibit#peritumoral lymphocyte accumulation and immunoblast cells with large vesicular nuclei and irregular nucleoli
#20203
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
exhibit
→
Object:
atypical_mitotic_figures
(Cell morphology)
Original: neoplastic cells#exhibit#prominent nucleoli/ hyperchromatic nuclei/ and atypical mitotic figures
#20202
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
exhibit
→
Object:
hyperchromatic_nuclei
(Cell morphology)
Original: neoplastic cells#exhibit#prominent nucleoli/ hyperchromatic nuclei/ and atypical mitotic figures
#20201
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
exhibit
→
Object:
prominent_nucleoli
(Cell morphology)
Original: neoplastic cells#exhibit#prominent nucleoli/ hyperchromatic nuclei/ and atypical mitotic figures
#20200
high Confidence
Subject:
pseudohyperplastic_areas
(Histological structure)
→
lack
→
Object:
basal_cells
(Cell Type)
Original: pseudohyperplastic areas#lack#basal cells
#20199
high Confidence
Subject:
Intravascular_lymphomatosis
(Tumor)
→
presents_with
→
Object:
dermatologic_involvement
(Skin involvement)
Original: Intravascular lymphomatosis#presents with#central nervous system and dermatologic involvement
#20198
high Confidence
Subject:
Intravascular_lymphomatosis
(Tumor)
→
presents_with
→
Object:
central_nervous_system_involvement
(Nervous system involvement)
Original: Intravascular lymphomatosis#presents with#central nervous system and dermatologic involvement
#20197
high Confidence
Subject:
RDD_histiocytes
(Histiocytes)
→
show_positive_immunostaining_for
→
Object:
S100
(Protein markers)
Original: RDD histiocytes#show positive immunostaining for#CD68/ CD163/ S100/ OCT-2/ Cyclin D1
#20196
high Confidence
Subject:
RDD_histiocytes
(Histiocytes)
→
show_positive_immunostaining_for
→
Object:
CD163
(Protein markers)
Original: RDD histiocytes#show positive immunostaining for#CD68/ CD163/ S100/ OCT-2/ Cyclin D1
#20195
high Confidence
Subject:
RDD_histiocytes
(Histiocytes)
→
show_positive_immunostaining_for
→
Object:
CD68
(Protein markers)
Original: RDD histiocytes#show positive immunostaining for#CD68/ CD163/ S100/ OCT-2/ Cyclin D1
#20194
high Confidence
Subject:
neuronal_cells
(Nerve cells)
→
show
→
Object:
neuronal_marker
(Neural markers)
Original: needle aspirates#revealed#cells positive for GFAP and neuronal marker with prominent nucleoli
#20193
high Confidence
Subject:
neuronal_cells
(Nerve cells)
→
show
→
Object:
GFAP
(glial fibrillary acid protein)
Original: needle aspirates#revealed#cells positive for GFAP and neuronal marker with prominent nucleoli
#20192
high Confidence
Subject:
atypical_round_cells
(Tumor cell subtype)
→
are_positively_stained_for
→
Object:
Thyroglobulin
(protein)
Original: atypical round cells#are positively stained for#thyroglobulin
#20191
high Confidence
Subject:
mass
(Radiological entity)
→
is_diagnostic_of
→
Object:
poorly_differentiated_adenocarcinoma
(Tumor phenotype)
Original: Mass#diagnosed as#poorly differentiated adenocarcinoma
#20190
high Confidence
Subject:
Gleason_score
(Histopathological scoring)
→
ranges_to
→
Object:
5
(Numerical indicators)
Original: Gleason's score#ranges from#3 to 5
#20189
high Confidence
Subject:
Gleason_score
(Histopathological scoring)
→
ranges_from
→
Object:
3
(Numerical indicators)
Original: Gleason's score#ranges from#3 to 5
#20188
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_immunoreactive_for
→
Object:
HMB45
(protein)
Original: tumor cells#were immunoreactive for#S-100 protein/ Melan-A/ and HMB-45
#20187
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_immunoreactive_for
→
Object:
MLANA
(protein)
Original: tumor cells#were immunoreactive for#S-100 protein/ Melan-A/ and HMB-45
#20186
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_immunoreactive_for
→
Object:
S100B
(protein)
Original: tumor cells#were immunoreactive for#S-100 protein/ Melan-A/ and HMB-45
#20185
high Confidence
Subject:
epithelioid_angiomyolipoma
(Tumor)
→
is_recognized_as
→
Object:
recently_documented_tumor_entity
(Tumor type)
Original: Epithelioid angiomyolipoma#is recognized as#a recently documented tumor entity
#20184
high Confidence
Subject:
beta_2_microglobulin
(protein)
→
is
→
Object:
important_diagnostic_and_prognostic_tumor_marker
(Tumor markers)
Original: LDH and beta-2 microglobulin#are#important diagnostic and prognostic tumor markers
#20183
high Confidence
Subject:
LDH
(Enzymes)
→
is
→
Object:
important_diagnostic_and_prognostic_tumor_marker
(Tumor markers)
Original: LDH and beta-2 microglobulin#are#important diagnostic and prognostic tumor markers
#20182
high Confidence
Subject:
MART-1
(Molecular markers)
→
stains
→
Object:
tumor
(Tumor tissue)
Original: The tumor#stained with#HMB-45 and MART-1
#20181
high Confidence
Subject:
HMB-45
(Molecular markers)
→
stains
→
Object:
tumor
(Tumor tissue)
Original: The tumor#stained with#HMB-45 and MART-1
#20180
high Confidence
Subject:
gastric-type_ECA_component
(Tumor tissue composition)
→
tested_negative_for
→
Object:
high-risk_HPV
(Viral markers)
Original: The gastric-type ECA component#tested#negative for p16 and high-risk HPV
#20179
high Confidence
Subject:
gastric-type_ECA_component
(Tumor tissue composition)
→
tested_negative_for
→
Object:
p16
(Tumor markers)
Original: The gastric-type ECA component#tested#negative for p16 and high-risk HPV
#20178
high Confidence
Subject:
spherical_hyaline_cytoplasmic_inclusions
(Cellular substructure)
→
are_immunoreactive_for
→
Object:
sarcomeric_actin
(Cytoskeletal proteins)
Original: Spherical hyaline cytoplasmic inclusions#are immunoreactive for#vimentin and sarcomeric actin
#20177
high Confidence
Subject:
spherical_hyaline_cytoplasmic_inclusions
(Cellular substructure)
→
are_immunoreactive_for
→
Object:
vimentin
(Cytoskeletal proteins)
Original: Spherical hyaline cytoplasmic inclusions#are immunoreactive for#vimentin and sarcomeric actin
#20176
high Confidence
Subject:
vimentin
(Intermediate filament protein)
→
is_positive_marker_in
→
Object:
malignant_melanoma
(disease)
Original: Immunopositivity for S100 protein/ HMB45/ and vimentin#distinguishes#malignant melanomas
#20175
high Confidence
Subject:
HMB45
(Monoclonal antibodies)
→
is_positive_marker_in
→
Object:
malignant_melanoma
(disease)
Original: Immunopositivity for S100 protein/ HMB45/ and vimentin#distinguishes#malignant melanomas
#20174
high Confidence
Subject:
S100_protein
(Calcium Binding Protein)
→
is_positive_marker_in
→
Object:
malignant_melanoma
(disease)
Original: Immunopositivity for S100 protein/ HMB45/ and vimentin#distinguishes#malignant melanomas
#20173
high Confidence
Subject:
Blastemal_cells
(Germ Cell)
→
recognized_in
→
Object:
Wilms_tumor
(Disease Type)
Original: Blastemal cells#were recognized in#all cases as small/ round cells with slightly oval nucleoli and fine/ evenly dispersed chromatin
#20172
high Confidence
Subject:
SPC cases
(Tumor Cases)
→
indicated
→
Object:
diffuse positivity for synaptophysin
(Protein expression characteristics)
Original: SPC cases#indicated#diffuse positivity for chromogranin A and/or synaptophysin
#20171
high Confidence
Subject:
SPC cases
(Tumor Cases)
→
indicated
→
Object:
diffuse positivity for chromogranin A
(Protein expression characteristics)
Original: SPC cases#indicated#diffuse positivity for chromogranin A and/or synaptophysin
#20170
high Confidence
Subject:
tumor_cell
(Tumor cells)
→
shows
→
Object:
strong_diffuse_cytoplasmic_immunolabeling_for_vimentin
(Protein expression)
Original: tumor cells#show#strong and diffuse cytoplasmic immunolabeling for vimentin and other markers
#20169
high Confidence
Subject:
fine-needle_aspiration_cytology
(Detection Methods)
→
is_useful_for
→
Object:
diagnosis_of_distal_extremity_lesions
(Disease diagnosis)
Original: Fine-needle aspiration cytology#has been shown to be useful in#diagnosis of distal extremity lesions
#20168
high Confidence
Subject:
Histologic_diagnosis
(Histological diagnosis)
→
revealed
→
Object:
sclerosing_ductal_papilloma_with_atypical_apocrine_metaplasia
(Disease diagnosis)
Original: Histologic diagnosis#revealed#sclerosing ductal papilloma with atypical apocrine metaplasia
#20167
high Confidence
Subject:
hyperbasophilic_cells
(Cell Type)
→
confirms
→
Object:
PPBL
(disease)
Original: presence of monocytoid or hyperbasophilic cells#confirms#PPBL
#20166
high Confidence
Subject:
monocytoid_cells
(Cell Type)
→
confirms
→
Object:
PPBL
(disease)
Original: presence of monocytoid or hyperbasophilic cells#confirms#PPBL
#20165
high Confidence
Subject:
MYCN_amplification
(Gene amplification)
→
is_notable_for
→
Object:
pediatric_malignant_glioma
(Disease phenotype)
Original: MYCN amplification#is notable for#a pediatric malignant glioma
#20164
high Confidence
Subject:
malignant cells
(Tumor cells)
→
indicate
→
Object:
prostatic origin
(Organization Source)
Original: cytologic features#indicated#prostatic origin by large and often multiple nucleoli
#20163
high Confidence
Subject:
FNA_biopsy_smears
(Cytology specimens)
→
were_reviewed_in
→
Object:
fibrocystic_disease
(Benign lesions)
Original: FNA biopsy smears#were reviewed from#62 fibroadenoma/ 60 ductal carcinoma/ and 42 fibrocystic disease subjects
#20162
high Confidence
Subject:
FNA_biopsy_smears
(Cytology specimens)
→
were_reviewed_in
→
Object:
ductal_carcinoma
(Malignant tumors)
Original: FNA biopsy smears#were reviewed from#62 fibroadenoma/ 60 ductal carcinoma/ and 42 fibrocystic disease subjects
#20161
high Confidence
Subject:
FNA_biopsy_smears
(Cytology specimens)
→
were_reviewed_in
→
Object:
fibroadenoma
(Benign tumors)
Original: FNA biopsy smears#were reviewed from#62 fibroadenoma/ 60 ductal carcinoma/ and 42 fibrocystic disease subjects
#20160
high Confidence
Subject:
tumor_cells
(Cell Type)
→
show_immunoreactivity_for
→
Object:
smooth_muscle_actin
(Structural proteins)
Original: tumor cells#showed#immunoreactivity for pan-cytokeratins/ calponin/ p63/ and smooth muscle actin
#20159
high Confidence
Subject:
tumor_cells
(Cell Type)
→
show_immunoreactivity_for
→
Object:
p63
(Transcription Factors)
Original: tumor cells#showed#immunoreactivity for pan-cytokeratins/ calponin/ p63/ and smooth muscle actin
#20158
high Confidence
Subject:
tumor_cells
(Cell Type)
→
show_immunoreactivity_for
→
Object:
calponin
(protein)
Original: tumor cells#showed#immunoreactivity for pan-cytokeratins/ calponin/ p63/ and smooth muscle actin
#20157
high Confidence
Subject:
tumor_cells
(Cell Type)
→
show_immunoreactivity_for
→
Object:
pan_cytokeratins
(protein)
Original: tumor cells#showed#immunoreactivity for pan-cytokeratins/ calponin/ p63/ and smooth muscle actin
#20156
high Confidence
Subject:
lymphoid_cells
(Lymphocytes)
→
are_immunoreactive_to
→
Object:
Ki-67
(Proliferation markers)
Original: lymphoid cells#are immunoreactive to#CD20/ CD3/ CD4/ CD56/ TIA-1/ EBER/ Ki-67
#20155
high Confidence
Subject:
lymphoid_cells
(Lymphocytes)
→
are_immunoreactive_to
→
Object:
EBER
(Nucleic acid markers)
Original: lymphoid cells#are immunoreactive to#CD20/ CD3/ CD4/ CD56/ TIA-1/ EBER/ Ki-67
#20154
high Confidence
Subject:
lymphoid_cells
(Lymphocytes)
→
are_immunoreactive_to
→
Object:
TIA-1
(Immune markers)
Original: lymphoid cells#are immunoreactive to#CD20/ CD3/ CD4/ CD56/ TIA-1/ EBER/ Ki-67
#20153
high Confidence
Subject:
lymphoid_cells
(Lymphocytes)
→
are_immunoreactive_to
→
Object:
CD56
(Immune markers)
Original: lymphoid cells#are immunoreactive to#CD20/ CD3/ CD4/ CD56/ TIA-1/ EBER/ Ki-67
#20152
high Confidence
Subject:
lymphoid_cells
(Lymphocytes)
→
are_immunoreactive_to
→
Object:
CD4
(Immune markers)
Original: lymphoid cells#are immunoreactive to#CD20/ CD3/ CD4/ CD56/ TIA-1/ EBER/ Ki-67
#20151
high Confidence
Subject:
lymphoid_cells
(Lymphocytes)
→
are_immunoreactive_to
→
Object:
CD3
(Immune markers)
Original: lymphoid cells#are immunoreactive to#CD20/ CD3/ CD4/ CD56/ TIA-1/ EBER/ Ki-67
#20150
high Confidence
Subject:
lymphoid_cells
(Lymphocytes)
→
are_immunoreactive_to
→
Object:
CD20
(Immune markers)
Original: lymphoid cells#are immunoreactive to#CD20/ CD3/ CD4/ CD56/ TIA-1/ EBER/ Ki-67
#20149
high Confidence
Subject:
HS-SY-II_cells
(Human tumor cell lines)
→
express
→
Object:
cytokeratin
(Cytokeratin)
Original: HS-SY-II cells#express#vimentin and cytokeratin by immunohistochemistry
#20148
high Confidence
Subject:
HS-SY-II_cells
(Human tumor cell lines)
→
express
→
Object:
vimentin
(Intermediate filament protein)
Original: HS-SY-II cells#express#vimentin and cytokeratin by immunohistochemistry
#20147
high Confidence
Subject:
HS-SY-II_cells
(Human tumor cell lines)
→
show
→
Object:
t(X;18)(p11;q11)_translocation
(Chromosomal translocation)
Original: HS-SY-II cells#show#a hypertriploid karyotype with complex chromosome abnormalities including pathognomonic t(X;18)(p11;q11)
#20146
high Confidence
Subject:
liver_transplantation
(Organ transplantation treatment)
→
treats
→
Object:
liver_disease_patient
(patient)
Original: liver transplantation#is an effective treatment for#patients with many kinds of liver diseases
#20145
high Confidence
Subject:
FNA_smear
(Cytology)
→
is_useful_for
→
Object:
cytologic_differential_diagnosis
(Diagnostic Process)
Original: FNA smears#together with#HMCK immunohistochemistry can be useful for the cytologic differential diagnosis of renal tumors
#20144
high Confidence
Subject:
all_cases
(Case Collection)
→
had
→
Object:
histologic_confirmation_of_diagnosis
(Diagnostic Process)
Original: all cases#had#histologic confirmation of the diagnosis
#20143
high Confidence
Subject:
SPTCL
(disease)
→
presents_with
→
Object:
hemophagocytic_lymphohistiocytosis
(disease)
Original: SPTCL#presents with#hemophagocytic lymphohistiocytosis and skin lesions
#20142
high Confidence
Subject:
cytomorphologic_features
(Cell morphology)
→
help
→
Object:
distinguish_benign_and_malignant_endometrial_lesions
(Diagnostic value)
Original: Cytomorphologic features#help#distinguish benign and malignant endometrial lesions
#20141
high Confidence
Subject:
stereotactic_biopsy
(Diagnostic techniques)
→
diagnosed
→
Object:
lymphoma
(disease)
Original: Stereotactic biopsy#diagnosed#lymphoma
#20140
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
S-100_protein
(Protein markers)
Original: Immunohistochemical staining#showed#tumor cells positive for Vimentin/ CD34/ Melan-A/ HMB45/ and S-100
#20139
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
HMB45
(Protein markers)
Original: Immunohistochemical staining#showed#tumor cells positive for Vimentin/ CD34/ Melan-A/ HMB45/ and S-100
#20138
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
Melan-A
(Protein markers)
Original: Immunohistochemical staining#showed#tumor cells positive for Vimentin/ CD34/ Melan-A/ HMB45/ and S-100
#20137
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD34
(Protein markers)
Original: Immunohistochemical staining#showed#tumor cells positive for Vimentin/ CD34/ Melan-A/ HMB45/ and S-100
#20136
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
Vimentin
(Protein markers)
Original: Immunohistochemical staining#showed#tumor cells positive for Vimentin/ CD34/ Melan-A/ HMB45/ and S-100
#20135
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
CD68
(Protein markers)
Original: Tumor cells#were positive for#S-100 protein and CD68
#20134
high Confidence
Subject:
Tumor_cells
(Tumor cells)
→
are_positive_for
→
Object:
S-100_protein
(Protein markers)
Original: Tumor cells#were positive for#S-100 protein and CD68
#20133
high Confidence
Subject:
Ki-67_staining
(Molecular markers)
→
assists_in
→
Object:
diagnosis_of_hyalinizing_trabecular_tumor
(Disease diagnosis)
Original: Ki-67 staining#can assist in#diagnosis of HTT
#20132
high Confidence
Subject:
Tumor
(Tumor tissue)
→
is_diagnosed_as
→
Object:
acinar_cell_carcinoma_of_pancreas
(Neoplastic diseases)
Original: Tumor#is diagnosed as#acinar cell carcinoma of the pancreas
#20131
high Confidence
Subject:
biopsy_findings
(Histological diagnosis)
→
diagnosed
→
Object:
histiocytic_sarcoma
(Disease phenotype)
Original: biopsy findings#diagnosed#histiocytic sarcoma
#20130
high Confidence
Subject:
alpha_smooth_muscle_actin
(protein)
→
shows
→
Object:
negative_reaction
(Test results)
Original: Epithelial membrane antigen (EMA)/ cytokeratin/ and alpha-smooth muscle action (alpha-SMA)#showed#negative reactions
#20129
high Confidence
Subject:
cytokeratin
(protein)
→
shows
→
Object:
negative_reaction
(Test results)
Original: Epithelial membrane antigen (EMA)/ cytokeratin/ and alpha-smooth muscle action (alpha-SMA)#showed#negative reactions
#20128
high Confidence
Subject:
epithelial_membrane_antigen
(protein)
→
shows
→
Object:
negative_reaction
(Test results)
Original: Epithelial membrane antigen (EMA)/ cytokeratin/ and alpha-smooth muscle action (alpha-SMA)#showed#negative reactions
#20127
high Confidence
Subject:
Lysosome
(Organelles)
→
shows
→
Object:
positive_reaction
(Test results)
Original: Alpha 1-antichymotrypsin (alpha 1-ACT)/ vimentin/ and lysosome#showed#positive reactions
#20126
high Confidence
Subject:
vimentin
(protein)
→
shows
→
Object:
positive_reaction
(Test results)
Original: Alpha 1-antichymotrypsin (alpha 1-ACT)/ vimentin/ and lysosome#showed#positive reactions
#20125
high Confidence
Subject:
alpha_1_antichymotrypsin
(protein)
→
shows
→
Object:
positive_reaction
(Test results)
Original: Alpha 1-antichymotrypsin (alpha 1-ACT)/ vimentin/ and lysosome#showed#positive reactions
#20124
high Confidence
Subject:
congenital_malignant_extrarenal_rhabdoid_tumor
(Tumor)
→
is_located_in
→
Object:
right_paratesticular_area
(Anatomical location)
Original: congenital malignant extrarenal rhabdoid tumor#is located in#right paratesticular area
#20123
high Confidence
Subject:
fine-needle_aspiration_cytology
(Diagnostic Methods)
→
reveals
→
Object:
invasive_ductal_carcinoma
(Tumor type)
Original: Fine-needle aspiration cytology#revealed#invasive ductal carcinoma
#20122
high Confidence
Subject:
cytologic_evaluation
(Diagnostic Methods)
→
achieves
→
Object:
diagnosis_of_pulmonary_metastasis
(Tumor type)
Original: Cytologic evaluation#achieved#diagnosis of pulmonary metastasis
#20121
high Confidence
Subject:
cytological_diagnosis
(Diagnostic Methods)
→
is_confirmed_by
→
Object:
pleomorphic_carcinoma
(Tumor type)
Original: Findings#confirmed#cytological diagnosis of pleomorphic carcinoma
#20120
high Confidence
Subject:
Resected_tumor_tissue
(Tumor tissue)
→
showed
→
Object:
immunoreactivity_for_somatostatin
(Protein expression characteristics)
Original: Resected tumor tissue#showed#immunoreactivity for alpha-fetoprotein/ neuron-specific enolase/ and somatostatin
#20119
high Confidence
Subject:
Resected_tumor_tissue
(Tumor tissue)
→
showed
→
Object:
immunoreactivity_for_neuron_specific_enolase
(Protein expression characteristics)
Original: Resected tumor tissue#showed#immunoreactivity for alpha-fetoprotein/ neuron-specific enolase/ and somatostatin
#20118
high Confidence
Subject:
Resected_tumor_tissue
(Tumor tissue)
→
showed
→
Object:
immunoreactivity_for_alpha_fetoprotein
(Protein expression characteristics)
Original: Resected tumor tissue#showed#immunoreactivity for alpha-fetoprotein/ neuron-specific enolase/ and somatostatin
#20117
high Confidence
Subject:
radiological_examination
(Imaging tests)
→
shows
→
Object:
compression_of_cervical_spinal_cord
(Imaging findings)
Original: radiological examination#showed#clivus bone destruction and compression of brain stem and cervical spinal cord
#20116
high Confidence
Subject:
radiological_examination
(Imaging tests)
→
shows
→
Object:
compression_of_brain_stem
(Imaging findings)
Original: radiological examination#showed#clivus bone destruction and compression of brain stem and cervical spinal cord
#20115
high Confidence
Subject:
radiological_examination
(Imaging tests)
→
shows
→
Object:
clivus_bone_destruction
(Imaging findings)
Original: radiological examination#showed#clivus bone destruction and compression of brain stem and cervical spinal cord
#20114
high Confidence
Subject:
INI1_gene
(Protein coding genes)
→
shows_genetic_abnormalities_in
→
Object:
tumor
(Tumor tissue)
Original: Four tumors#showed#genetic abnormalities involving the INI1 gene
#20113
high Confidence
Subject:
IVLBCL_tumor_cells
(Tumor cells)
→
express
→
Object:
PAX5
(Transcription Factors)
Original: IVLBCL tumor cells#express#CD20 and PAX5
#20112
high Confidence
Subject:
IVLBCL_tumor_cells
(Tumor cells)
→
express
→
Object:
CD20
(Membrane receptor protein)
Original: IVLBCL tumor cells#express#CD20 and PAX5
#20111
high Confidence
Subject:
peripheral_primitive_neuroectodermal_tumor
(Rare tumors)
→
is
→
Object:
rare_diagnostically_challenging_tumor_in_CNS
(Rare tumor characteristics)
Original: Meningeal Ewing Sarcoma (ES)/peripheral primitive neuroectodermal tumor (pPNET)#is#a rare diagnostically challenging tumor in the CNS
#20110
high Confidence
Subject:
meningeal_ewing_sarcoma
(Rare tumors)
→
is
→
Object:
rare_diagnostically_challenging_tumor_in_CNS
(Rare tumor characteristics)
Original: Meningeal Ewing Sarcoma (ES)/peripheral primitive neuroectodermal tumor (pPNET)#is#a rare diagnostically challenging tumor in the CNS
#20109
high Confidence
Subject:
patients
(patient)
→
are_diagnosed_with
→
Object:
Sertoli-stromal_cell_tumors
(Tumor)
Original: Patients#are diagnosed with#unclassified sex cord-stromal tumors or Sertoli-stromal cell tumors
#20108
high Confidence
Subject:
patients
(patient)
→
are_diagnosed_with
→
Object:
unclassified_sex_cord-stromal_tumors
(Tumor)
Original: Patients#are diagnosed with#unclassified sex cord-stromal tumors or Sertoli-stromal cell tumors
#20107
high Confidence
Subject:
fine_needle_aspiration_biopsy
(Diagnostic techniques)
→
is_used_to_analyze
→
Object:
renal_tumors_in_children
(Tumor)
Original: Fine needle aspiration biopsy#is used to analyze#renal tumors in children
#20106
high Confidence
Subject:
morphologic_features
(Histological characteristics)
→
are_consistent_with
→
Object:
rhabdoid_meningioma
(Disease diagnosis)
Original: Morphologic features#are consistent with#diagnosis of rhabdoid meningioma
#20105
high Confidence
Subject:
Smooth_muscle_actin
(Protein markers)
→
is_positive_in
→
Object:
smooth_muscle_cells
(Cell Type)
Original: Smooth muscle actin#is positive in#all cases
#20104
high Confidence
Subject:
gastric_glomus_tumor
(Tumor type)
→
is_diagnosed_by
→
Object:
fine_needle_aspiration_of_stomach
(Diagnostic Methods)
Original: gastric glomus tumor#is diagnosed by#fine needle aspiration of the stomach
#20103
high Confidence
Subject:
FNA_cytology
(Fine needle aspiration cytology)
→
shows_efficacy_in
→
Object:
presurgical_evaluation_of_testicular_masses
(Diagnostic Process)
Original: FNA cytology#shows#efficacy in presurgical evaluation of testicular masses
#20102
high Confidence
Subject:
fine_needle_aspiration_cytology
(Diagnostic techniques)
→
is_used_for
→
Object:
primary_hepatic_neoplasms
(Primary liver tumor)
Original: Fine-needle aspiration cytology#is used for#diagnosis of primary hepatic neoplasms
#20101
high Confidence
Subject:
tubular_adenocarcinoma
(Tumor type)
→
shows
→
Object:
well_differentiated
(Differentiation level)
Original: endoscopic submucosal dissection#revealed#tubular adenocarcinoma/ well-differentiated/ with slight submucosal invasion
#20100
high Confidence
Subject:
neoplastic_cell
(Tumor cells)
→
is_positive_for
→
Object:
epithelial_membrane_antigen
(protein)
Original: neoplastic cells#are positive for#cytokeratin and epithelial membrane antigen
#20099
high Confidence
Subject:
neoplastic_cell
(Tumor cells)
→
is_positive_for
→
Object:
cytokeratin
(protein)
Original: neoplastic cells#are positive for#cytokeratin and epithelial membrane antigen
#20098
high Confidence
Subject:
cytologic_grading
(Cytological grading)
→
determines
→
Object:
choice_of_therapy
(Treatment options)
Original: combined histologic and cytologic grading of prostate carcinomas#determines#choice of therapy based on staging
#20097
high Confidence
Subject:
histologic_grading
(Histological grading)
→
determines
→
Object:
choice_of_therapy
(Treatment options)
Original: combined histologic and cytologic grading of prostate carcinomas#determines#choice of therapy based on staging
#20096
high Confidence
Subject:
protein_complex
(Protein complex)
→
mediates
→
Object:
p53_degradation
(Protein degradation)
Original: This complex#mediates#degradation of tumor suppressor p53 and Mpp10 in nucleolus
#20095
high Confidence
Subject:
5-azacytidine
(DNA methylation inhibitors)
→
inhibits
→
Object:
rRNA_processing
(Ribosomal RNA processing)
Original: 5-azacytidine#inhibits#rRNA processing
#20094
high Confidence
Subject:
rDNA_copies
(Genomic DNA)
→
are
→
Object:
epigenetically_silenced
(Epigenetic status)
Original: One half of rDNA copies#are#epigenetically silenced
#20093
high Confidence
Subject:
tumorigenesis
(Tumor development process)
→
is_linked_to
→
Object:
ribosome_biogenesis
(Cellular Processes)
Original: Tumorigenesis#is linked to#ribosome biogenesis
#20092
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
ribosome_biogenesis
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#20091
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
centrosome_duplication
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#20090
high Confidence
Subject:
cAMP
(Small molecules)
→
activates
→
Object:
cAMP-dependent_protein_kinase
(Protein kinase)
Original: Cyclic AMP (cAMP)#activates#cyclic AMP-dependent protein kinase
#20089
high Confidence
Subject:
Cajal_bodies
(Subcellular structure)
→
contain
→
Object:
RNA_processing_components
(Molecular complex)
Original: Cajal bodies (CBs)#contain#components of RNA transcription and RNA processing pathways
#20088
high Confidence
Subject:
Cajal_bodies
(Subcellular structure)
→
contain
→
Object:
RNA_transcription_components
(Molecular complex)
Original: Cajal bodies (CBs)#contain#components of RNA transcription and RNA processing pathways
#20087
high Confidence
Subject:
targeted_therapeutics
(Targeted therapy drugs)
→
interrupt
→
Object:
bone_degradation
(Bone degradation process)
Original: targeted therapeutics#interrupt#cycle of tumor development and bone degradation
#20086
high Confidence
Subject:
targeted_therapeutics
(Targeted therapy drugs)
→
interrupt
→
Object:
tumor_development
(Tumor development process)
Original: targeted therapeutics#interrupt#cycle of tumor development and bone degradation
#20085
high Confidence
Subject:
NPM1
(Protein coding genes)
→
is_associated_with
→
Object:
cytoplasmic_localization_in_AML
(Abnormal molecular localization)
Original: One-third of acute myeloid leukemias (AMLs)#are associated with#aberrant localization of NPM1 to the cytoplasm (NPM1c+)
#20084
high Confidence
Subject:
p14ARF
(Tumor suppressor proteins)
→
increases
→
Object:
p21_expression
(Protein expression)
Original: p14ARF#increases#transcription and expression of p21
#20083
high Confidence
Subject:
p14ARF
(Tumor suppressor proteins)
→
inhibits
→
Object:
HDM2
(Ubiquitin ligase)
Original: p14ARF#activates#p53 by binding and inhibiting HDM2
#20082
high Confidence
Subject:
p14ARF
(Tumor suppressor proteins)
→
binds_to
→
Object:
HDM2
(Ubiquitin ligase)
Original: p14ARF#activates#p53 by binding and inhibiting HDM2
#20081
high Confidence
Subject:
p14ARF
(Tumor suppressor proteins)
→
activates
→
Object:
p53
(Transcription Factors)
Original: p14ARF#activates#p53 by binding and inhibiting HDM2
#20080
high Confidence
Subject:
p53_expression
(Protein expression)
→
is_useful_as
→
Object:
prognostic_indicator
(Clinical outcome measures)
Original: DNA ploidy and p53 expression#are useful as#prognostic indicators in HCC
#20079
high Confidence
Subject:
DNA_ploidy
(Genomic features)
→
is_useful_as
→
Object:
prognostic_indicator
(Clinical outcome measures)
Original: DNA ploidy and p53 expression#are useful as#prognostic indicators in HCC
#20078
high Confidence
Subject:
Dyskeratosis_congenita
(Genetic disorders)
→
is_associated_with
→
Object:
increased_cancer_susceptibility
(Disease phenotype)
Original: Dyskeratosis congenita#is associated with#increased susceptibility to cancer
#20077
high Confidence
Subject:
Hepatitis_delta_virus_protein
(Viral Protein)
→
localizes_to
→
Object:
nucleolus
(Subcellular structure)
Original: Hepatitis delta virus proteins#localize#to the nucleolus in the absence of viral RNA replication
#20076
high Confidence
Subject:
guanine_nucleotide_depletion
(Metabolic status)
→
causes
→
Object:
nucleolar_protein_translocation
(Subcellular structural changes)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#translocation of nucleolar proteins to the nucleoplasm
#20075
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion
→
Object:
45S_precursor_rRNA_synthesis
(rRNA transcription synthesis)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#a reduction in levels of 45S precursor rRNA synthesis
#20074
high Confidence
Subject:
PPP2CB
(Protein coding genes)
→
enables
→
Object:
CDC14
(Protein coding genes)
Original: Downregulation of PP2A(Cdc55)#enables#release of Cdc14p from the nucleolus
#20073
high Confidence
Subject:
E
(Molecular complex)
→
suppresses
→
Object:
rRNA_transcription
(rRNA transcription process)
Original: eNoSC#suppresses#rRNA transcription in response to glucose starvation
#20072
high Confidence
Subject:
NPM1
(Protein coding genes)
→
is_overexpressed_in
→
Object:
tumor
(Tumor phenotype)
Original: Nucleophosmin (NPM)#is found overexpressed in#many types of tumors
#20071
high Confidence
Subject:
MYC
(Protein coding genes)
→
activates
→
Object:
RNA_polymerase_I_transcription
(Transcription process)
Original: c-Myc#activates#RNA polymerase I-mediated transcription of ribosomal RNA genes
#20070
high Confidence
Subject:
TIF-IA
(Transcription Factors)
→
is_inactivated_by
→
Object:
homologous_recombination
(Gene Editing Technology)
Original: TIF-IA gene#was inactivated by#homologous recombination in mice and MEFs
#20069
high Confidence
Subject:
translation_machinery_misregulation
(Protein synthesis mechanism)
→
is_associated_with
→
Object:
cancer
(Disease phenotype)
Original: Mis-regulation of nucleolar functions and translation machinery#has been associated with#many types of cancer
#20068
high Confidence
Subject:
nucleolar_function_misregulation
(Function of cellular substructures)
→
is_associated_with
→
Object:
cancer
(Disease phenotype)
Original: Mis-regulation of nucleolar functions and translation machinery#has been associated with#many types of cancer
#20067
high Confidence
Subject:
Ribosome methylation profiles
(Molecular Modification Omics)
→
is_altered_in
→
Object:
cancer
(Disease phenotype)
Original: snoRNA expression and ribosome methylation profiles#are altered in#cancer
#20066
high Confidence
Subject:
snoRNA expression
(Noncoding RNA expression)
→
is_altered_in
→
Object:
cancer
(Disease phenotype)
Original: snoRNA expression and ribosome methylation profiles#are altered in#cancer
#20065
high Confidence
Subject:
DKC1
(Ribosome modifying enzymes)
→
catalysts
→
Object:
pseudo-uridylation_of_rRNA
(RNA modification)
Original: Dyskerin#carries out#pseudo-uridylation of rRNA and stabilization of telomerase RNA
#20064
high Confidence
Subject:
ZGar
(Virus)
→
leads_to
→
Object:
nucleolar_structural_disruption
(Changes in nucleolar structure)
Original: ZIKV infection#leads to#ribosomal stress and nucleolar structural disruption
#20063
high Confidence
Subject:
ZGar
(Virus)
→
leads_to
→
Object:
ribosomal_stress
(Stress response)
Original: ZIKV infection#leads to#ribosomal stress and nucleolar structural disruption
#20062
high Confidence
Subject:
NOLC1
(Nucleolus-associated protein)
→
interacts_with
→
Object:
fibrillarin
(RNA methyltransferase)
Original: NOLC1#interacts with#fibrillarin in the nucleolus
#20061
high Confidence
Subject:
nucleolus_organizer_regions
(Chromosome structural region)
→
are_used_in
→
Object:
pathomorphologic_tumor_diagnosis
(Tumor pathology diagnosis)
Original: Nucleolus organizer regions#are used in#pathomorphologic tumor diagnosis
#20060
high Confidence
Subject:
apoptosis_execution_phase
(Cellular Processes)
→
is_characterized_by
→
Object:
membrane_blebbing
(Cell morphology changes)
Original: Apoptosis execution phase#is characterized by#membrane blebbing
#20059
high Confidence
Subject:
SGO2
(Protein coding genes)
→
promotes
→
Object:
EMT
(Cellular Processes)
Original: SGO2#promoted#cell proliferation/ cell migration/ invasion/ and EMT of A549 cells
#20058
high Confidence
Subject:
SGO2
(Protein coding genes)
→
promotes
→
Object:
cell_invasion
(Cellular Processes)
Original: SGO2#promoted#cell proliferation/ cell migration/ invasion/ and EMT of A549 cells
#20057
high Confidence
Subject:
SGO2
(Protein coding genes)
→
promotes
→
Object:
cell_migration
(Cellular Processes)
Original: SGO2#promoted#cell proliferation/ cell migration/ invasion/ and EMT of A549 cells
#20056
high Confidence
Subject:
SGO2
(Protein coding genes)
→
promotes
→
Object:
cell_proliferation
(Cellular Processes)
Original: SGO2#promoted#cell proliferation/ cell migration/ invasion/ and EMT of A549 cells
#20055
high Confidence
Subject:
SGO2
(Protein coding genes)
→
facilitates
→
Object:
cell_proliferation
(Cellular Processes)
Original: SGO2#facilitated#cell proliferation and regulated cell cycle through upregulating E2F1
#20054
high Confidence
Subject:
SGO2
(Protein coding genes)
→
upregulates
→
Object:
E2F1
(Transcription Factors)
Original: SGO2#facilitated#cell proliferation and regulated cell cycle through upregulating E2F1
#20053
high Confidence
Subject:
SGO2
(Protein coding genes)
→
reduces
→
Object:
cell_apoptosis
(Cellular Processes)
Original: SGO2#contributed to#cell cycle progression and reduced cell apoptosis
#20052
high Confidence
Subject:
SGO2
(Protein coding genes)
→
contributes_to
→
Object:
cell_cycle_progression
(Cell cycle regulation)
Original: SGO2#contributed to#cell cycle progression and reduced cell apoptosis
#20051
high Confidence
Subject:
SGO2
(Protein coding genes)
→
knockdown_impedes
→
Object:
EMT
(Cellular Processes)
Original: SGO2 knockdown#impeded#cell proliferation/ cell migration/ invasion/ and EMT
#20050
high Confidence
Subject:
SGO2
(Protein coding genes)
→
knockdown_impedes
→
Object:
cell_invasion
(Cellular Processes)
Original: SGO2 knockdown#impeded#cell proliferation/ cell migration/ invasion/ and EMT
#20049
high Confidence
Subject:
SGO2
(Protein coding genes)
→
knockdown_impedes
→
Object:
cell_migration
(Cellular Processes)
Original: SGO2 knockdown#impeded#cell proliferation/ cell migration/ invasion/ and EMT
#20048
high Confidence
Subject:
SGO2
(Protein coding genes)
→
knockdown_impedes
→
Object:
cell_proliferation
(Cellular Processes)
Original: SGO2 knockdown#impeded#cell proliferation/ cell migration/ invasion/ and EMT
#20047
high Confidence
Subject:
PLCG2
(Enzymes)
→
is_identified_as
→
Object:
novel_biomarker_for_ccRCC
(Diagnostic markers)
Original: PLCG2#is identified as#a novel biomarker for ccRCC
#20046
high Confidence
Subject:
nucleolar_parafibromin
(protein)
→
is_absent_in
→
Object:
parathyroid_carcinoma
(Tumor)
Original: nucleolar parafibromin#is absent in#parathyroid carcinomas
#20045
high Confidence
Subject:
LC3_proteins
(Autophagy-related proteins)
→
are_used_as
→
Object:
major_markers_of_autophagy
(Molecular markers)
Original: endogenous LC3 proteins#are used as#major markers of autophagy
#20044
high Confidence
Subject:
patients_with_pancreatic_cancer
(Patient population)
→
develop
→
Object:
cachexia
(Disease phenotype)
Original: patients with pancreatic cancer#develops#cachexia
#20043
high Confidence
Subject:
Patients
(patient)
→
were_treated_with
→
Object:
DXT
(Radiation therapy)
Original: Patients#suffered from#oral squamous cell carcinoma and were treated with surgery and DXT
#20042
high Confidence
Subject:
Patients
(patient)
→
were_treated_with
→
Object:
surgery
(Surgery)
Original: Patients#suffered from#oral squamous cell carcinoma and were treated with surgery and DXT
#20041
high Confidence
Subject:
Patients
(patient)
→
suffered_from
→
Object:
oral_squamous_cell_carcinoma
(Oral squamous cell carcinoma)
Original: Patients#suffered from#oral squamous cell carcinoma and were treated with surgery and DXT
#20040
high Confidence
Subject:
nucleolar_stress
(Molecular stress response)
→
upregulates
→
Object:
p53
(Transcription Factors)
Original: nucleolar stress#upregulated#p53
#20039
high Confidence
Subject:
cytologic_findings
(Cytology)
→
included
→
Object:
neuroendocrine_tumor
(Tumor)
Original: Cytologic findings#included#hepatocellular/ adrenal/ and renal carcinomas/ melanoma/ mesothelioma/ and neuroendocrine tumors
#20038
high Confidence
Subject:
cytologic_findings
(Cytology)
→
included
→
Object:
mesothelioma
(Tumor)
Original: Cytologic findings#included#hepatocellular/ adrenal/ and renal carcinomas/ melanoma/ mesothelioma/ and neuroendocrine tumors
#20037
high Confidence
Subject:
cytologic_findings
(Cytology)
→
included
→
Object:
melanoma
(Tumor)
Original: Cytologic findings#included#hepatocellular/ adrenal/ and renal carcinomas/ melanoma/ mesothelioma/ and neuroendocrine tumors
#20036
high Confidence
Subject:
cytologic_findings
(Cytology)
→
included
→
Object:
renal_carcinoma
(Tumor)
Original: Cytologic findings#included#hepatocellular/ adrenal/ and renal carcinomas/ melanoma/ mesothelioma/ and neuroendocrine tumors
#20035
high Confidence
Subject:
cytologic_findings
(Cytology)
→
included
→
Object:
adrenal_carcinoma
(Tumor)
Original: Cytologic findings#included#hepatocellular/ adrenal/ and renal carcinomas/ melanoma/ mesothelioma/ and neuroendocrine tumors
#20034
high Confidence
Subject:
cytologic_findings
(Cytology)
→
included
→
Object:
hepatocellular_carcinoma
(Tumor)
Original: Cytologic findings#included#hepatocellular/ adrenal/ and renal carcinomas/ melanoma/ mesothelioma/ and neuroendocrine tumors
#20033
high Confidence
Subject:
Fine_needle_aspiration_cytology
(Diagnostic techniques)
→
diagnoses
→
Object:
Carcinoma_breast
(disease)
Original: 60 carcinoma breast cases#were diagnosed on#fine needle aspiration cytology
#20032
high Confidence
Subject:
NCL
(Nucleolin)
→
is_marker_of
→
Object:
cancer
(Disease phenotype)
Original: nucleolin#is#a major component of silver-stained nucleolar organizer region and a marker of cancer
#20031
high Confidence
Subject:
ACKD-RCC
(Kidney tumors)
→
arises_from
→
Object:
proximal_renal_tubule
(Renal tubules)
Original: ACKD-RCC#arises from#the proximal renal tubule
#20030
high Confidence
Subject:
Cyclin_D1
(Cell cycle proteins)
→
is_unique_prognostic_marker_for
→
Object:
human_HCC
(Disease phenotype)
Original: Cyclin D1 immunostaining#is a unique prognostic marker for#human HCC
#20029
high Confidence
Subject:
Endometrial_adenocarcinoma
(Tumor type)
→
is_graded_by
→
Object:
nuclear_grading_system
(Rating system)
Original: Endometrial adenocarcinomas#are graded by#FIGO system and nuclear grading system
#20028
high Confidence
Subject:
Endometrial_adenocarcinoma
(Tumor type)
→
is_graded_by
→
Object:
FIGO_system
(Rating system)
Original: Endometrial adenocarcinomas#are graded by#FIGO system and nuclear grading system
#20027
high Confidence
Subject:
SNORA23_level_in_PDAC
(Noncoding RNA)
→
inversely_correlated_with
→
Object:
disease-free_survival
(Clinical Outcomes)
Original: SNORA23 level in PDAC#correlated with#invasion grade and inversely with disease-free survival
#20026
high Confidence
Subject:
SNORA23_level_in_PDAC
(Noncoding RNA)
→
correlated_with
→
Object:
invasion_grade
(Pathological grading)
Original: SNORA23 level in PDAC#correlated with#invasion grade and inversely with disease-free survival
#20025
high Confidence
Subject:
basal-cell_hyperplasia
(Histopathological type)
→
accounted_for
→
Object:
cases
(Number of cases)
Original: basal-cell hyperplasia with nucleoli#accounted for#11% of cases
#20024
high Confidence
Subject:
adenosis
(Histopathological type)
→
accounted_for
→
Object:
cases
(Number of cases)
Original: adenosis#accounted for#50% of cases
#20023
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
are_immunoreactive_for
→
Object:
chromogranin_A
(Neuroendocrine markers)
Original: The neoplastic cells#stained positive#with Grimelius stain and were immunoreactive for synaptophysin and chromogranin A
#20022
high Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
are_immunoreactive_for
→
Object:
synaptophysin
(Neuroendocrine markers)
Original: The neoplastic cells#stained positive#with Grimelius stain and were immunoreactive for synaptophysin and chromogranin A
#20021
high Confidence
Subject:
malignant_cells
(Tumor cells)
→
showed_positive_staining_with
→
Object:
beta-HCG
(Hormone markers)
Original: Malignant cells#showed#positive staining with CD30/ ALK/ epithelial membrane antigen/ and beta-HCG
#20020
high Confidence
Subject:
malignant_cells
(Tumor cells)
→
showed_positive_staining_with
→
Object:
epithelial_membrane_antigen
(Protein markers)
Original: Malignant cells#showed#positive staining with CD30/ ALK/ epithelial membrane antigen/ and beta-HCG
#20019
high Confidence
Subject:
CK7
(Cytokeratin)
→
was_detected_by
→
Object:
Immunohistochemistry
(Detection Methods)
Original: Expression of Ki67/ p53/ CEA/ CDX/ and CK7#was detected by#immunohistochemistry
#20018
high Confidence
Subject:
CDX2
(Transcription Factors)
→
was_detected_by
→
Object:
Immunohistochemistry
(Detection Methods)
Original: Expression of Ki67/ p53/ CEA/ CDX/ and CK7#was detected by#immunohistochemistry
#20017
high Confidence
Subject:
CEA
(protein)
→
was_detected_by
→
Object:
Immunohistochemistry
(Detection Methods)
Original: Expression of Ki67/ p53/ CEA/ CDX/ and CK7#was detected by#immunohistochemistry
#20016
high Confidence
Subject:
Intestinal_intraepithelial_lymphocytes
(Immune cells)
→
are_composed_of
→
Object:
heterogeneous_subsets_with_diverse_phenotypes
(Immune cell subsets)
Original: Intestinal intraepithelial lymphocytes#are composed of#heterogeneous subsets with diverse phenotypes
#20015
high Confidence
Subject:
Epstein_Barr_virus_encoded_small_RNA
(Viral RNA)
→
is_detected_using
→
Object:
in_situ_hybridization
(Molecular detection technology)
Original: Epstein-Barr virus-encoded small RNA#is detected using#in situ hybridization
#20014
high Confidence
Subject:
cases
(Case)
→
can_be_recognized_by
→
Object:
neuroendocrine_marker_staining
(Molecular markers)
Original: cases#can be recognized by#nests and cords/ amphophilic cytoplasm/ Paneth cell-like eosinophilic granules/ indistinct nucleoli/ and neuroendocrine marker staining
#20013
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
KRT20
(protein)
Original: tumor cells#were negative for#CAM5.2 and cytokeratins 7 and 20
#20012
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
KRT7
(protein)
Original: tumor cells#were negative for#CAM5.2 and cytokeratins 7 and 20
#20011
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
are_negative_for
→
Object:
CAM5.2
(protein)
Original: tumor cells#were negative for#CAM5.2 and cytokeratins 7 and 20
#20010
high Confidence
Subject:
NUT_midline_carcinoma
(Tumor diseases)
→
has
→
Object:
characteristic_morphological_features
(Pathological characteristics)
Original: NMC#has#characteristic morphological features and positive immunostaining with NUT antibody
#20009
high Confidence
Subject:
SPTCL
(disease)
→
presents_with
→
Object:
skin_lesions
(Clinical symptoms)
Original: SPTCL#presents with#hemophagocytic lymphohistiocytosis and skin lesions
#20008
high Confidence
Subject:
invasive_ductal_carcinoma
(Breast cancer)
→
shows
→
Object:
frequent_mitotic_figures
(Cell division)
Original: invasive ductal carcinoma#showed#solid pattern/ high nuclear and structural atypia/ frequent mitotic figures
#20007
high Confidence
Subject:
invasive_ductal_carcinoma
(Breast cancer)
→
shows
→
Object:
high_structural_atypia
(Tissue abnormalities)
Original: invasive ductal carcinoma#showed#solid pattern/ high nuclear and structural atypia/ frequent mitotic figures
#20006
high Confidence
Subject:
invasive_ductal_carcinoma
(Breast cancer)
→
shows
→
Object:
high_nuclear_atypia
(Cell abnormalities)
Original: invasive ductal carcinoma#showed#solid pattern/ high nuclear and structural atypia/ frequent mitotic figures
#20005
high Confidence
Subject:
invasive_ductal_carcinoma
(Breast cancer)
→
shows
→
Object:
solid_pattern
(Organizational form)
Original: invasive ductal carcinoma#showed#solid pattern/ high nuclear and structural atypia/ frequent mitotic figures
#20004
high Confidence
Subject:
patients
(patient)
→
underwent
→
Object:
chemotherapy
(Treatment)
Original: patients#underwent#surgical resection and chemotherapy
#20003
high Confidence
Subject:
patients
(patient)
→
underwent
→
Object:
surgical_resection
(Treatment)
Original: patients#underwent#surgical resection and chemotherapy
#20002
high Confidence
Subject:
c-Myc
(Transcription Factors)
→
induces
→
Object:
changes_in_nucleolar_structural_integrity
(Changes in cell structure)
Original: c-Myc#induces#changes in nucleolar structural integrity
#20000
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
nucleolar_stress_response
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#19999
high Confidence
Subject:
flow_cytometry
(Cell function analysis)
→
evaluates
→
Object:
apoptosis
(Apoptosis)
Original: colony formation/ CCK-8 assay/ and flow cytometry#evaluate#cell viability/ cell cycle/ and apoptosis
#19998
high Confidence
Subject:
CCK-8_assay
(Cell function analysis)
→
evaluates
→
Object:
cell_cycle
(Cell cycle)
Original: colony formation/ CCK-8 assay/ and flow cytometry#evaluate#cell viability/ cell cycle/ and apoptosis
#19997
high Confidence
Subject:
colony_formation_assay
(Cell function analysis)
→
evaluates
→
Object:
cell_viability
(Cell viability)
Original: colony formation/ CCK-8 assay/ and flow cytometry#evaluate#cell viability/ cell cycle/ and apoptosis
#19996
high Confidence
Subject:
CST1
(Caspase inhibitors)
→
promotes
→
Object:
metastatic_capacity_of_ESCC_cells
(Transfer process)
Original: Upregulated CST1#can promote#the motility and metastatic capacity of ESCC in vitro and in vivo
#19995
high Confidence
Subject:
CST1
(Caspase inhibitors)
→
promotes
→
Object:
Motility_of_ESCC_cells
(Cellular Processes)
Original: Upregulated CST1#can promote#the motility and metastatic capacity of ESCC in vitro and in vivo
#19994
high Confidence
Subject:
PML
(Tumor suppressor proteins)
→
regulates
→
Object:
post-translational_modifications
(Protein modification)
Original: PML tumour-suppressor protein#regulates#post-translational modifications
#19993
high Confidence
Subject:
MKI67
(Cell proliferation marker proteins)
→
is_used_to_assess
→
Object:
proliferation_in_carcinoma_in_situ
(Proliferation (carcinoma in situ))
Original: Ki-67#is used to assess#proliferation in high-grade dysplasia and carcinoma in situ in colorectal adenomas
#19992
high Confidence
Subject:
MKI67
(Cell proliferation marker proteins)
→
is_used_to_assess
→
Object:
proliferation_in_high-grade_dysplasia
(Proliferation (high-grade intraepithelial neoplasia))
Original: Ki-67#is used to assess#proliferation in high-grade dysplasia and carcinoma in situ in colorectal adenomas