临床相关性：Carcinogenic mechanism
A total of 19 records found
#22126
high Confidence
Subject:
NRG1
(Protein coding genes)
→
is_oncogenic_driver_in
→
Object:
solid_tumors
(Tumor)
Original: NRG1 gene fusions#are#emerging oncogenic drivers in solid tumors
#20942
high Confidence
Subject:
NUT
(Protein coding genes)
→
forms_fusion_oncogene_with
→
Object:
BRD4
(Protein coding genes)
Original: The BRD4 gene#forms#a fusion oncogene BRD4-NUT through translocation
#20941
high Confidence
Subject:
BRD4
(Protein coding genes)
→
forms_fusion_oncogene_with
→
Object:
NUT
(Protein coding genes)
Original: The BRD4 gene#forms#a fusion oncogene BRD4-NUT through translocation
#20367
high Confidence
Subject:
AOM
(Carcinogenic chemicals)
→
induces
→
Object:
ACF_in_rats
(Disease phenotype)
Original: AOM#induces#ACF in rats
#20293
high Confidence
Subject:
Helicobacter_pylori_infection
(Pathogenic factors)
→
acts_as_cofactor_in
→
Object:
gastric_carcinogenesis
(Tumor development process)
Original: H. pylori infection#plays a role as#a co-factor in gastric carcinogenesis
#20069
high Confidence
Subject:
translation_machinery_misregulation
(Protein synthesis mechanism)
→
is_associated_with
→
Object:
cancer
(Disease phenotype)
Original: Mis-regulation of nucleolar functions and translation machinery#has been associated with#many types of cancer
#20068
high Confidence
Subject:
nucleolar_function_misregulation
(Function of cellular substructures)
→
is_associated_with
→
Object:
cancer
(Disease phenotype)
Original: Mis-regulation of nucleolar functions and translation machinery#has been associated with#many types of cancer
#19911
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
contributes_to
→
Object:
NPM1c+_tumorigenesis
(Tumorigenesis)
Original: NPM1#has#indirect but significant role in BER and NPM1c+ tumorigenesis
#19787
middle Confidence
Subject:
Helicobacter_pylori_infection
(Pathogenic factors)
→
is_associated_with
→
Object:
increased_cell_proliferation_activity
(Cellular Processes)
Original: Helicobacter pylori infection#is associated with#increased cell proliferation activity
#18964
middle Confidence
Subject:
phase_separation
(Molecular Process)
→
facilitates
→
Object:
cancer_associated_signaling_pathways
(signaling pathway)
Original: Phase separation#coalesces#mutant oncoproteins and facilitates cancer-associated signaling pathways
#18963
middle Confidence
Subject:
phase_separation
(Molecular Process)
→
coalesces
→
Object:
mutant_oncoproteins
(protein)
Original: Phase separation#coalesces#mutant oncoproteins and facilitates cancer-associated signaling pathways
#18551
middle Confidence
Subject:
4-nitroquinoline_1-oxide
(Chemical carcinogens)
→
induces
→
Object:
carcinoma
(Malignant tumors)
Original: Papillomas and carcinomas#were induced in#rat tongues by 4-nitroquinoline 1-oxide
#18550
middle Confidence
Subject:
4-nitroquinoline_1-oxide
(Chemical carcinogens)
→
induces
→
Object:
papilloma
(Benign tumors)
Original: Papillomas and carcinomas#were induced in#rat tongues by 4-nitroquinoline 1-oxide
#17229
middle Confidence
Subject:
CircRNAs
(Circular RNA)
→
regulate
→
Object:
tumorigenesis
(Tumor development process)
Original: CircRNAs#regulate#tumorigenesis and metastasis
#16726
middle Confidence
Subject:
AOM_exposure
(Environmental carcinogen exposure)
→
induces
→
Object:
colon_carcinogenesis
(Tumor development process)
Original: AOM exposure#induces#colon carcinogenesis in animals
#12099
middle Confidence
Subject:
chromosomal_material_8q
(chromosomal region)
→
affects
→
Object:
MYC
(Protein coding genes)
Original: chromosomal material in 8q#affects#c-myc gene
#7365
middle Confidence
Subject:
N-(4'-fluoro-4-biphenylyl)acetamide_(FBPA)
(Chemical small molecules)
→
induces
→
Object:
histogenesis_of_renal_adenocarcinoma
(Tumor development process)
Original: histogenesis of renal adenocarcinoma#is induced by#N-(4'-fluoro-4-biphenylyl)acetamide (FBPA)
#1723
low Confidence
Subject:
rat_tongue
(Animal tissue)
→
develops
→
Object:
carcinoma
(Malignant tumors)
Original: Papillomas and carcinomas#were induced in#rat tongues by 4-nitroquinoline 1-oxide
#1722
low Confidence
Subject:
rat_tongue
(Animal tissue)
→
develops
→
Object:
papilloma
(Benign tumors)
Original: Papillomas and carcinomas#were induced in#rat tongues by 4-nitroquinoline 1-oxide