临床相关性：Diagnosis/Prognosis
A total of 67 records found
#22171
high Confidence
Subject:
MYCN
(Protein coding genes)
→
is_amplified_in
→
Object:
neuroblastoma
(Tumor type)
Original: MYCN amplification#was confirmed by#fluorescence in situ hybridization
#22060
high Confidence
Subject:
EGFR_mutation
(Gene mutation)
→
detected_in
→
Object:
colon_cancer
(Tumor)
Original: Mutations#detected in#APC/ TP53/ RB1/ FBWX7/ RET/ EGFR/ FLT3
#22059
high Confidence
Subject:
TP53_mutation
(Gene mutation)
→
detected_in
→
Object:
colon_cancer
(Tumor)
Original: Mutations#detected in#APC/ TP53/ RB1/ FBWX7/ RET/ EGFR/ FLT3
#22058
high Confidence
Subject:
APC_mutation
(Gene mutation)
→
detected_in
→
Object:
colon_cancer
(Tumor)
Original: Mutations#detected in#APC/ TP53/ RB1/ FBWX7/ RET/ EGFR/ FLT3
#21995
high Confidence
Subject:
TP53
(Tumor suppressor proteins)
→
was_investigated_by
→
Object:
Immunohistochemistry
(Experimental techniques)
Original: Expressions of Endoglin (CD105)/ VEGF/ and p53#were investigated by#immunohistochemistry
#21994
high Confidence
Subject:
VEGF
(Growth Factors)
→
was_investigated_by
→
Object:
Immunohistochemistry
(Experimental techniques)
Original: Expressions of Endoglin (CD105)/ VEGF/ and p53#were investigated by#immunohistochemistry
#21993
high Confidence
Subject:
CD105
(Membrane Protein)
→
was_investigated_by
→
Object:
Immunohistochemistry
(Experimental techniques)
Original: Expressions of Endoglin (CD105)/ VEGF/ and p53#were investigated by#immunohistochemistry
#21942
high Confidence
Subject:
granulocytic_sarcoma_in_AML
(Tumor type)
→
have
→
Object:
chromosome_translocation_t(8;21)
(Chromosomal abnormalities)
Original: Granulocytic sarcomas in AML#have#chromosome translocation t(8;21)
#21875
high Confidence
Subject:
BCL2
(Anti-apoptotic proteins)
→
is_expressed_in
→
Object:
neoplastic_cells
(Tumor cells)
Original: neoplastic cells#express#B-cell markers (CD19/ CD20/ CD79a/ PAX5/ BCL-2)
#21561
high Confidence
Subject:
SGO2
(Protein coding genes)
→
is_overexpressed_in
→
Object:
Cancer
(Tumor type)
Original: SGO2#is found to be#overexpressed in 25 of 33 cancer types/ including LUAD
#21560
high Confidence
Subject:
SGO2
(Protein coding genes)
→
is_overexpressed_in
→
Object:
LUAD
(Tumor type)
Original: SGO2#is found to be#overexpressed in 25 of 33 cancer types/ including LUAD
#21546
high Confidence
Subject:
AgNOR_score
(Histological markers)
→
is_significantly_higher_in
→
Object:
pancreatic_carcinoma_tissue
(Tumor tissue)
Original: Ag-NOR score#is significantly higher in#pancreatic carcinoma tissues compared to normal pancreatic tissues
#21386
high Confidence
Subject:
AgNOR_distribution
(Molecular pathology indicators)
→
is_used_for
→
Object:
tumor_diagnosis
(Tumor Diagnosis)
Original: AgNOR distribution#is used for#diagnostic and prognostic purposes of tumors
#21378
high Confidence
Subject:
CD105
(Membrane Protein)
→
is_upregulated_in
→
Object:
tumor_tissue
(Tumor tissue)
Original: Endoglin (CD105) expression#was higher in#tumor tissue compared to normal mucosa
#21111
high Confidence
Subject:
neoplastic_cell_nuclei
(Nucleus)
→
express
→
Object:
Ki67
(Proliferation markers)
Original: The nuclei of many neoplastic cells#expressed#the proliferation marker Ki67
#20935
high Confidence
Subject:
tumor_cells
(Tumor cells)
→
showed
→
Object:
membranous_positivity_for_Ki-67
(Protein expression)
Original: Tumor cells#showed#distinctive membranous positivity for Ki-67
#20850
high Confidence
Subject:
accurate_diagnosis
(Diagnostic behavior)
→
is_required_for
→
Object:
soft_tissue_tumors_with_poor_prognosis
(Tumor type)
Original: accurate diagnosis#is required for#soft tissue tumors with poor prognosis
#20830
high Confidence
Subject:
immunohistochemical_staining_with_MoAb_Ki-67
(Immunohistochemistry)
→
evaluates
→
Object:
proliferative_activity_of_brain_tumors
(Tumor proliferation activity)
Original: immunohistochemical staining with MoAb Ki-67#can evaluate#proliferative activity of brain tumors
#20807
high Confidence
Subject:
unusual_RCC
(Disease classification)
→
shows
→
Object:
rhabdoid_morphology
(Cell morphology)
Original: unusual RCC#shows#rhabdoid morphology and poor prognosis
#20569
high Confidence
Subject:
NPM1_gene
(Protein coding genes)
→
is_mutated_in
→
Object:
Leukemia
(Tumor phenotype)
Original: NPM1 gene#is translocated or mutated in#lymphomas and leukemias
#20568
high Confidence
Subject:
NPM1_gene
(Protein coding genes)
→
is_translocated_in
→
Object:
lymphoma
(Tumor phenotype)
Original: NPM1 gene#is translocated or mutated in#lymphomas and leukemias
#20419
high Confidence
Subject:
NCL
(Ribosomal proteins)
→
correlates_with
→
Object:
iCCA_occurrence
(Disease phenotype)
Original: Nucleolin#correlates with#iCCA occurrence and progression
#20313
high Confidence
Subject:
AgNOR_counts
(Nucleolar organizer region-associated protein count)
→
indicates
→
Object:
proliferative_activity_of_cancer_cells
(Tumor cell proliferation activity)
Original: Proliferative activity of cancer cells#is indicated by#AgNOR counts in gastric adenocarcinoma
#20046
high Confidence
Subject:
nucleolar_parafibromin
(protein)
→
is_absent_in
→
Object:
parathyroid_carcinoma
(Tumor)
Original: nucleolar parafibromin#is absent in#parathyroid carcinomas
#19981
middle Confidence
Subject:
FLT3_mutation
(Gene mutation)
→
detected_in
→
Object:
colon_cancer
(Tumor)
Original: Mutations#detected in#APC/ TP53/ RB1/ FBWX7/ RET/ EGFR/ FLT3
#19980
middle Confidence
Subject:
RET_mutation
(Gene mutation)
→
detected_in
→
Object:
colon_cancer
(Tumor)
Original: Mutations#detected in#APC/ TP53/ RB1/ FBWX7/ RET/ EGFR/ FLT3
#19979
middle Confidence
Subject:
FBXW7_mutation
(Gene mutation)
→
detected_in
→
Object:
colon_cancer
(Tumor)
Original: Mutations#detected in#APC/ TP53/ RB1/ FBWX7/ RET/ EGFR/ FLT3
#19978
middle Confidence
Subject:
RB1_mutation
(Gene mutation)
→
detected_in
→
Object:
colon_cancer
(Tumor)
Original: Mutations#detected in#APC/ TP53/ RB1/ FBWX7/ RET/ EGFR/ FLT3
#19970
middle Confidence
Subject:
p53_oncogene
(Tumor suppressor genes)
→
has
→
Object:
prognostic_value_in_laryngeal_cancer
(Prognostic value)
Original: p53 oncogene and neoplastic markers#have#diagnostic and prognostic value in laryngeal cancer
#19969
middle Confidence
Subject:
p53_oncogene
(Tumor suppressor genes)
→
has
→
Object:
diagnostic_value_in_laryngeal_cancer
(Diagnostic value)
Original: p53 oncogene and neoplastic markers#have#diagnostic and prognostic value in laryngeal cancer
#19857
middle Confidence
Subject:
CA72-4
(Tumor markers)
→
correlates_with
→
Object:
proliferative_activity_of_cancer_cells_in_gastric_adenocarcinoma
(Cellular Processes)
Original: Pre-operative serum levels of CEA and CA72-4#correlate with#proliferative activity of cancer cells in gastric adenocarcinoma
#19856
middle Confidence
Subject:
CEA
(Tumor markers)
→
correlates_with
→
Object:
proliferative_activity_of_cancer_cells_in_gastric_adenocarcinoma
(Cellular Processes)
Original: Pre-operative serum levels of CEA and CA72-4#correlate with#proliferative activity of cancer cells in gastric adenocarcinoma
#19690
middle Confidence
Subject:
AgNOR
(Nucleolar organizer region-associated protein)
→
represented
→
Object:
marker_of_cell_proliferation_rate
(Cell proliferation rate markers)
Original: AgNOR#is considered to represent#a marker of cell proliferation rate in tumor pathology
#19319
middle Confidence
Subject:
enlarged_nucleoli
(Nuclear morphology)
→
are_associated_with
→
Object:
malignant_cases
(Disease phenotype)
Original: enlarged nucleoli#are associated with#malignant cases
#19239
middle Confidence
Subject:
patients_with_atypical_glands
(Patient characteristics)
→
require
→
Object:
repeat_biopsies
(Clinical operation)
Original: patients with atypical glands suspicious for carcinoma#are subject to#close monitoring and repeat biopsies
#19218
middle Confidence
Subject:
TOP2A
(DNA topoisomerase)
→
is_highly_expressed_in
→
Object:
seminomas
(Seminomas)
Original: Topoisomerase IIalpha#is highly expressed in#high-grade lymphomas and seminomas
#19217
middle Confidence
Subject:
TOP2A
(DNA topoisomerase)
→
is_highly_expressed_in
→
Object:
high-grade_lymphomas
(Lymphoma)
Original: Topoisomerase IIalpha#is highly expressed in#high-grade lymphomas and seminomas
#19131
middle Confidence
Subject:
CCND1
(protein)
→
is_overexpressed_in
→
Object:
breast_cancer
(Tumor type)
Original: cyclin D1 overexpression#is found in#breast cancer and other human cancers
#18976
middle Confidence
Subject:
PLCG2
(Enzymes)
→
is_downregulated_in
→
Object:
ccRCC_tissues_and_cells
(Tumor tissue/cells)
Original: PLCG2#is downregulated in#ccRCC tissues and cells
#18615
middle Confidence
Subject:
multivariate_discriminant_analysis
(Statistical analysis methods)
→
estimates
→
Object:
predictive_value_for_tumor_malignancy
(Diagnostic predictors)
Original: Multivariate discriminant analysis#estimates#predictive values for tumor malignancy
#18606
middle Confidence
Subject:
neoplastic_markers
(Tumor markers)
→
has
→
Object:
prognostic_value_in_laryngeal_cancer
(Prognostic value)
Original: p53 oncogene and neoplastic markers#have#diagnostic and prognostic value in laryngeal cancer
#18605
middle Confidence
Subject:
neoplastic_markers
(Tumor markers)
→
has
→
Object:
diagnostic_value_in_laryngeal_cancer
(Diagnostic value)
Original: p53 oncogene and neoplastic markers#have#diagnostic and prognostic value in laryngeal cancer
#18033
middle Confidence
Subject:
leptomeningeal_melanomatosis
(disease)
→
is_associated_with
→
Object:
neurocutaneous_melanosis
(disease)
Original: leptomeningeal melanomatosis#is associated with#neurocutaneous melanosis
#17314
middle Confidence
Subject:
malignancy_diagnosis
(Diagnostic Process)
→
requires
→
Object:
prognostic_factors
(Prognostic factors)
Original: Malignancy diagnosis#requires#consideration of prognostic factors
#17069
middle Confidence
Subject:
AgNORs
(Nucleolus-associated silver chromosome structure)
→
is_marker_of
→
Object:
proliferative_index_in_tumors
(Cellular Processes)
Original: AgNORs#are identified as#a marker of proliferative index in tumors
#16803
middle Confidence
Subject:
NOP2
(Ribosomal RNA methyltransferase)
→
serves_as
→
Object:
proliferation_marker_in_neoplastic_cells
(Biomarkers)
Original: NOP2#serves as#marker for proliferation in neoplastic cells
#16555
middle Confidence
Subject:
proliferating_index_of_PCNA_positive_cells
(Cell proliferation index)
→
is_closely_related_to
→
Object:
AgNOR_area
(Molecular modification area)
Original: Proliferating index (PI) of PCNA-positive cells#is closely related to#AgNORs count and area
#16554
middle Confidence
Subject:
proliferating_index_of_PCNA_positive_cells
(Cell proliferation index)
→
is_closely_related_to
→
Object:
AgNOR_count
(Number of molecular modifications)
Original: Proliferating index (PI) of PCNA-positive cells#is closely related to#AgNORs count and area
#16183
middle Confidence
Subject:
Epithelioid_cells
(Cell Type)
→
have
→
Object:
chance_of_invasive_melanoma
(Tumor phenotype)
Original: Lesions composed of epithelioid cells#have#a 75-90% chance of invasive melanoma
#15843
middle Confidence
Subject:
AgNOR_quantity_in_hepatocytes
(Molecular markers)
→
is_associated_with
→
Object:
risk_of_hepatocellular_carcinoma
(Disease Risk)
Original: High AgNOR quantity in hepatocytes#is associated with#increased risk of hepatocellular carcinoma
#15338
middle Confidence
Subject:
nuclear_features
(Nuclear characteristics)
→
correlate_with
→
Object:
PD-L1_expression
(Protein expression)
Original: nuclear features#might be correlated with#PD-L1 expression in lung adenocarcinoma
#12490
middle Confidence
Subject:
CCND1
(protein)
→
is_overexpressed_in
→
Object:
other_human_cancers
(Tumor type)
Original: cyclin D1 overexpression#is found in#breast cancer and other human cancers
#12148
middle Confidence
Subject:
p120_protein
(Cell junction proteins)
→
serves_as
→
Object:
proliferation_marker_in_lung_cancer_cells
(Biomarkers)
Original: p120 protein#serves as#marker for proliferation in lung cancer cells
#11859
middle Confidence
Subject:
TP53
(Tumor suppressor proteins)
→
was_investigated_in
→
Object:
non-Hodgkin's_lymphomas
(Tumor type)
Original: Prognostic value of PCNA and p53 expression#was investigated in#non-Hodgkin's lymphomas
#11858
middle Confidence
Subject:
PCNA
(Proliferation-related proteins)
→
was_investigated_in
→
Object:
non-Hodgkin's_lymphomas
(Tumor type)
Original: Prognostic value of PCNA and p53 expression#was investigated in#non-Hodgkin's lymphomas
#11722
middle Confidence
Subject:
cell_proliferation_activity
(Cellular Processes)
→
is_assessed_by
→
Object:
AgNOR_silver_staining
(Staining detection method)
Original: Cell proliferation activity#is assessed by#MIB1 and AgNOR silver staining
#11721
middle Confidence
Subject:
cell_proliferation_activity
(Cellular Processes)
→
is_assessed_by
→
Object:
MIB1
(Protein markers)
Original: Cell proliferation activity#is assessed by#MIB1 and AgNOR silver staining
#10245
middle Confidence
Subject:
Sjögren's syndrome
(Autoimmune diseases)
→
should_consider
→
Object:
lymphoma
(Malignant tumors)
Original: Patients with Sj?gren's syndrome#should consider#possibility of lymphoma
#9716
middle Confidence
Subject:
AgNOR
(Nucleolar organizer region-associated protein)
→
predictive_value_strengthened_by
→
Object:
markers_of_cell_growth_kinetics
(Cell growth dynamics markers)
Original: Predictive value of AgNOR#is strengthened by#combination with markers of cell growth kinetics
#7997
middle Confidence
Subject:
histology_of_surgical_biopsies
(Histological characteristics)
→
examined_for
→
Object:
prognostic_markers_in_SCLC
(Molecular markers)
Original: histology of surgical biopsies#examined for#prognostic markers in SCLC
#6192
middle Confidence
Subject:
NORs
(Nucleolar Organizing Region Protein)
→
are_evaluated_on
→
Object:
paraffin_sections_of_malignant_melanomas
(Tissue samples)
Original: Nucleolar Organizer Region-associated proteins (NORs)#are evaluated on#paraffin sections of cutaneous malignant melanomas
#6187
middle Confidence
Subject:
SOYBEAN_AGGLUTININ_stained_cells
(Labeling cells)
→
is_greater_in
→
Object:
infiltrating_carcinoma
(disease)
Original: Modifications to nuclear area/ perimeter/ DNA content/ percentage of nuclei with nucleoli/ nuclear/cytoplasmic ratio/ and SOYA BEAN AGGLUTININ stained cells#are progressively greater from#normal epithelium to infiltrating carcinoma
#6186
middle Confidence
Subject:
nuclear_cytoplasmic_ratio
(Nuclear-cytoplasmic ratio)
→
is_greater_in
→
Object:
infiltrating_carcinoma
(disease)
Original: Modifications to nuclear area/ perimeter/ DNA content/ percentage of nuclei with nucleoli/ nuclear/cytoplasmic ratio/ and SOYA BEAN AGGLUTININ stained cells#are progressively greater from#normal epithelium to infiltrating carcinoma
#6185
middle Confidence
Subject:
percentage_of_nuclei_with_nucleoli
(Proportion of nuclei with nucleoli)
→
is_greater_in
→
Object:
infiltrating_carcinoma
(disease)
Original: Modifications to nuclear area/ perimeter/ DNA content/ percentage of nuclei with nucleoli/ nuclear/cytoplasmic ratio/ and SOYA BEAN AGGLUTININ stained cells#are progressively greater from#normal epithelium to infiltrating carcinoma
#6184
middle Confidence
Subject:
DNA_content
(DNA content)
→
is_greater_in
→
Object:
infiltrating_carcinoma
(disease)
Original: Modifications to nuclear area/ perimeter/ DNA content/ percentage of nuclei with nucleoli/ nuclear/cytoplasmic ratio/ and SOYA BEAN AGGLUTININ stained cells#are progressively greater from#normal epithelium to infiltrating carcinoma
#6183
middle Confidence
Subject:
nuclear_perimeter
(Nuclear circumference)
→
is_greater_in
→
Object:
infiltrating_carcinoma
(disease)
Original: Modifications to nuclear area/ perimeter/ DNA content/ percentage of nuclei with nucleoli/ nuclear/cytoplasmic ratio/ and SOYA BEAN AGGLUTININ stained cells#are progressively greater from#normal epithelium to infiltrating carcinoma
#6182
middle Confidence
Subject:
nuclear_area
(Nuclear area)
→
is_greater_in
→
Object:
infiltrating_carcinoma
(disease)
Original: Modifications to nuclear area/ perimeter/ DNA content/ percentage of nuclei with nucleoli/ nuclear/cytoplasmic ratio/ and SOYA BEAN AGGLUTININ stained cells#are progressively greater from#normal epithelium to infiltrating carcinoma