临床相关性：Diagnostic/prognostic significance
A total of 45 records found
#22159
high Confidence
Subject:
Masood_Cytology_Index
(Cytological scoring system)
→
is_used_as
→
Object:
surrogate_biomarker
(Surrogate biomarkers)
Original: Masood Cytology Index#is used as#a surrogate biomarker in chemoprevention trials
#22102
high Confidence
Subject:
TP53
(Tumor suppressor proteins)
→
is_silenced_in
→
Object:
gastric_adenocarcinoma
(disease)
Original: staining for TP53 overexpression#was negative in#gastric adenocarcinoma
#21642
high Confidence
Subject:
MYC
(Protein coding genes)
→
amplification_correlates_with
→
Object:
overexpression_of_MYC
(Protein expression)
Original: C-MYC amplification#was correlated with#overexpression of C-MYC/ TERT/ and FBL
#21451
high Confidence
Subject:
nuclear_pleomorphism
(Nuclear heterogeneity)
→
is_associated_with
→
Object:
BR_Grade_3_on_histology
(Histology High Level)
Original: marked nuclear pleomorphism#is associated with#BR Grade 3 on histology
#21402
high Confidence
Subject:
Ki-67
(Proliferation markers)
→
shows_high_proliferation_index_in
→
Object:
tumor
(Tumor tissue)
Original: Tumors#were diffusely positive for#p53 and showed high Ki-67 proliferation index
#21373
high Confidence
Subject:
Proliferative_activity
(Cellular Processes)
→
is_evaluated_by
→
Object:
AgNOR_count
(Molecular markers)
Original: Proliferative activity#is evaluated by#Ki-67 immunohistochemistry and AgNOR count
#21372
high Confidence
Subject:
Proliferative_activity
(Cellular Processes)
→
is_evaluated_by
→
Object:
Ki-67_immunohistochemistry
(Immunohistochemistry)
Original: Proliferative activity#is evaluated by#Ki-67 immunohistochemistry and AgNOR count
#20992
high Confidence
Subject:
endometrioid_adenocarcinoma
(Tumor type)
→
exhibits
→
Object:
superficial_invasion_of_myometrium
(Pathological characteristics)
Original: endometrioid adenocarcinomas#exhibit#superficial invasion of myometrium and no lymph node metastasis
#20542
high Confidence
Subject:
UBA2
(Protease)
→
is_overexpressed_in
→
Object:
glioma_cell_lines
(Tumor cell lines)
Original: UBA2#is overexpressed in#glioma tissues and cell lines
#20541
high Confidence
Subject:
UBA2
(Protease)
→
is_overexpressed_in
→
Object:
glioma_tissues
(Tumor tissue)
Original: UBA2#is overexpressed in#glioma tissues and cell lines
#20519
high Confidence
Subject:
MYC
(Protein coding genes)
→
increased_expression_in
→
Object:
invasive_breast_carcinoma
(Disease phenotype)
Original: FISH analysis#demonstrated#increased (>5) C-MYC signals per nucleus
#20518
high Confidence
Subject:
MYC
(Protein coding genes)
→
amplified_in
→
Object:
invasive_breast_carcinoma
(Disease phenotype)
Original: C-MYC amplification#was identified in#18 additional cases of invasive breast carcinomas
#20416
high Confidence
Subject:
ECT2
(Guanine nucleotide exchange factor)
→
is_overexpressed_in
→
Object:
cancer
(Tumor)
Original: ECT2#is overexpressed in#many cancers
#20286
high Confidence
Subject:
TP53
(Transcription Factors)
→
is_positive_in
→
Object:
tumor
(Tumor tissue)
Original: Tumors#were diffusely positive for#p53 and showed high Ki-67 proliferation index
#20271
high Confidence
Subject:
B-cell_prolymphocytic_leukemia
(B-cell prolymphocytic leukemia)
→
have
→
Object:
complex_karyotype_including_chromosomal_translocation_8_14_q24_q32
(Chromosomal translocation)
Original: B-cell prolymphocytic leukemia#had#complex karyotype including chromosomal translocation (8;14) (q24;q32)
#20235
high Confidence
Subject:
TBrC
(Tumor subtype)
→
has_characteristic
→
Object:
higher_tumor_grade
(Tumor grade)
Original: TNBrCa#have characteristic histologic features including#higher tumor grade/ pushing tumor border/ geographic necrosis/ syncytial growth pattern
#19804
middle Confidence
Subject:
psammomatous_calcifications
(Calcification deposits)
→
were_associated_with
→
Object:
psammocarcinoma
(Tumor type)
Original: psammomatous calcifications#were associated with#psammocarcinoma in 4 cases
#19617
middle Confidence
Subject:
PD-L1
(Immune Checkpoint Proteins)
→
is_highly_expressed_in
→
Object:
tumor_cells
(Tumor cells)
Original: Three cases#presented with#high expression of PD-L1
#19457
middle Confidence
Subject:
meningotheliomatous_meningiomas
(Tumor type)
→
exhibit
→
Object:
atypical_features
(Pathological characteristics)
Original: masses#identified as#meningotheliomatous meningiomas with atypical features
#19157
middle Confidence
Subject:
MYC
(Protein coding genes)
→
amplification_correlates_with
→
Object:
overexpression_of_FBL
(Protein expression)
Original: C-MYC amplification#was correlated with#overexpression of C-MYC/ TERT/ and FBL
#19156
middle Confidence
Subject:
MYC
(Protein coding genes)
→
amplification_correlates_with
→
Object:
overexpression_of_TERT
(Protein expression)
Original: C-MYC amplification#was correlated with#overexpression of C-MYC/ TERT/ and FBL
#18948
middle Confidence
Subject:
AgNORs_number_in_malignant_thyroid_lesions
(Nuclear morphology)
→
exceeded
→
Object:
AgNORs_number_in_benign_thyroid_lesions
(Nuclear morphology)
Original: number of AgNORs in malignant thyroid lesions#exceeded#those in benign thyroid lesions
#18814
middle Confidence
Subject:
non-diagnostic_but_suspicious_lesion
(Cytological changes)
→
is_more_likely_to_be
→
Object:
malignant_lesion
(Malignant lesions)
Original: non-diagnostic but suspicious lesions#are more likely to be#malignant
#18600
middle Confidence
Subject:
Pleomorphic_adenoma
(Benign tumors)
→
is_considered
→
Object:
benign_tumor
(Benign tumors)
Original: Pleomorphic adenoma (PA)#is considered#benign tumor which may recur and rarely metastasize
#18570
middle Confidence
Subject:
AgNOR
(Molecular markers)
→
correlates_with
→
Object:
malignant_grading
(Clinical characteristics)
Original: Silver-binding argyrophilic nucleolar organizer regions (AgNOR)#correlate with#malignant grading and prognosis
#18545
middle Confidence
Subject:
mucoepidermoid_carcinoma_grade
(Tumor grade)
→
correlates_with
→
Object:
AgNOR_count
(Nucleolar organizer region-associated protein)
Original: Correlation between mucoepidermoid carcinoma grade and AgNOR count#was observed in#patients
#16663
middle Confidence
Subject:
Ki67
(Cell proliferation markers)
→
is_immunostained_in
→
Object:
radical_prostatectomy_slides
(Tissue sections)
Original: cytokeratin 5/ GSTP1/ c-MET/ C/EBPbeta/ Ki-67#are immunostained in#radical prostatectomy slides
#16595
middle Confidence
Subject:
AgNOR_staining
(Dyeing technology)
→
predictions
→
Object:
malignant_behavior_in_stromal_tumors
(Disease phenotype)
Original: Silver staining of interphase nucleolar organizer regions (AgNORs)#predicts#malignant behavior in stromal tumors
#16537
middle Confidence
Subject:
MDM2_protein_expression
(Protein expression)
→
can_indicate
→
Object:
lip_carcinogenesis
(Tumorigenesis)
Original: p53 and MDM2 protein expression#can indicate#lip carcinogenesis
#16536
middle Confidence
Subject:
p53_protein_expression
(Protein expression)
→
can_indicate
→
Object:
lip_carcinogenesis
(Tumorigenesis)
Original: p53 and MDM2 protein expression#can indicate#lip carcinogenesis
#15822
middle Confidence
Subject:
CVR
(Molecular markers)
→
is_independent_of
→
Object:
lymph_node_status
(Clinical characteristics)
Original: Prognostic value of CVRSa#is independent of#conventional criteria like age/ tumor size/ grading/ and lymph node status
#15821
middle Confidence
Subject:
CVR
(Molecular markers)
→
is_independent_of
→
Object:
grading
(Clinical characteristics)
Original: Prognostic value of CVRSa#is independent of#conventional criteria like age/ tumor size/ grading/ and lymph node status
#15820
middle Confidence
Subject:
CVR
(Molecular markers)
→
is_independent_of
→
Object:
tumor_size
(Clinical characteristics)
Original: Prognostic value of CVRSa#is independent of#conventional criteria like age/ tumor size/ grading/ and lymph node status
#15819
middle Confidence
Subject:
CVR
(Molecular markers)
→
is_independent_of
→
Object:
age
(Clinical characteristics)
Original: Prognostic value of CVRSa#is independent of#conventional criteria like age/ tumor size/ grading/ and lymph node status
#15684
middle Confidence
Subject:
NPM_expression
(Protein expression)
→
was_assessed_relative_to
→
Object:
clinicopathological_variables
(Clinical pathological variables)
Original: NPM expression#was assessed relative to#clinicopathological variables and histological subtypes
#15682
middle Confidence
Subject:
AgNOR_count
(Molecular markers)
→
is_higher_in
→
Object:
poorly_differentiated_neoplasms
(Tumor classification)
Original: AgNOR count#is higher in#poorly differentiated neoplasms compared to well-differentiated ones
#13775
middle Confidence
Subject:
Prostatic_adenocarcinoma_cases
(Tumor Cases)
→
exhibit
→
Object:
variably_prominent_nucleoli
(Cell morphology)
Original: Prostatic adenocarcinoma cases#exhibit#variably prominent nucleoli
#11619
middle Confidence
Subject:
nuclear_margin
(Nuclear structural characteristics)
→
is_most_influential_feature_for
→
Object:
breast_carcinoma
(Tumor diseases)
Original: multiple regression analysis#revealed#cell dissociation/ nucleoli/ and nuclear margin as the most influential features
#11618
middle Confidence
Subject:
nucleoli
(Nuclear structural characteristics)
→
is_most_influential_feature_for
→
Object:
breast_carcinoma
(Tumor diseases)
Original: multiple regression analysis#revealed#cell dissociation/ nucleoli/ and nuclear margin as the most influential features
#11617
middle Confidence
Subject:
cell_dissociation
(Cell phenotypic characteristics)
→
is_most_influential_feature_for
→
Object:
breast_carcinoma
(Tumor diseases)
Original: multiple regression analysis#revealed#cell dissociation/ nucleoli/ and nuclear margin as the most influential features
#11463
middle Confidence
Subject:
WHO_grading_system
(Rating system)
→
is
→
Object:
controversial_to_predict_tumor_behavior
(Controversy over predictive power)
Original: WHO grading system#is#controversial to predict tumor behavior
#9852
middle Confidence
Subject:
histological_criteria
(Histological criteria)
→
do_not_predict
→
Object:
recurrence_of_pleomorphic_adenoma
(Tumor recurrence)
Original: Histological criteria#do not predict#recurrences of pleomorphic adenoma
#5729
middle Confidence
Subject:
nuclear_polymorphism
(Nuclear components)
→
is_potentially_useful_as
→
Object:
surrogate_endpoint_biomarker
(Biomarkers)
Original: Measurements#are potentially useful as#surrogate endpoint biomarkers
#5728
middle Confidence
Subject:
nucleoli/nuclei
(Nuclear components)
→
is_potentially_useful_as
→
Object:
surrogate_endpoint_biomarker
(Biomarkers)
Original: Measurements#are potentially useful as#surrogate endpoint biomarkers
#5727
middle Confidence
Subject:
nucleolar_size
(Nuclear components)
→
is_potentially_useful_as
→
Object:
surrogate_endpoint_biomarker
(Biomarkers)
Original: Measurements#are potentially useful as#surrogate endpoint biomarkers