临床相关性：Poor prognosis
A total of 40 records found
#21739
high Confidence
Subject:
large_cell_transformation
(Cell phenotype changes)
→
signals
→
Object:
worse_prognosis
(Clinical Outcomes)
Original: Large cell transformation#signals#a worse prognosis in indolent B-cell lymphomas
#21664
high Confidence
Subject:
SPC25_CpG_hypomethylation
(DNA methylation modification sites)
→
is_associated_with
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: Hypomethylation of CpG sites in SPC25#is associated with#poor prognosis in UCEC patients
#21131
high Confidence
Subject:
SMARCA4_deficiency
(Loss of gene function)
→
is_associated_with
→
Object:
esophageal_carcinoma
(Tumor type)
Original: Esophageal carcinoma#is associated with#SMARCA4 deficiency or dysfunction
#20797
high Confidence
Subject:
immunosuppressive_drug
(Immunosuppressive drugs)
→
causes
→
Object:
increased_de_novo_malignancy_risk
(Disease Risk)
Original: immunosuppressive drugs#have been identified as#the primary culprit for increased risk of de novo malignancy in liver transplant recipients
#20696
high Confidence
Subject:
congenital_malignant_extrarenal_rhabdoid_tumor
(Tumor)
→
has
→
Object:
disseminated_metastases
(Metastatic phenotype)
Original: congenital malignant extrarenal rhabdoid tumor#has#disseminated metastases
#20375
high Confidence
Subject:
nucleolar_hypertrophy
(Cellular substructure phenotype)
→
is_associated_with
→
Object:
bad_prognosis_in_human_carcinomas
(Clinical Outcomes)
Original: nucleolar hypertrophy#is associated with#bad prognoses in human carcinomas
#19889
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
is_overexpressed_in
→
Object:
highly_proliferative_cells
(Cell Type)
Original: Nucleolin#is over-expressed in#highly proliferative cells
#19449
middle Confidence
Subject:
Gastric-type endocervical adenocarcinoma (GAS)
(Tumor subtype)
→
has_clinical_aggressiveness
→
Object:
aggressive_behavior
(Disease phenotype)
Original: GAS#is#a clinically aggressive variant of cervical adenocarcinoma
#19272
middle Confidence
Subject:
TRAF7_mutated_mesenchymal_tumor
(Gene mutation tumors)
→
is_characterized_by
→
Object:
aggressive_clinical_behavior
(Clinical manifestations)
Original: TRAF7-mutated mesenchymal tumor#is characterized by#aggressive clinical behavior
#19051
middle Confidence
Subject:
HSPB1
(Molecular chaperone proteins)
→
correlates_with
→
Object:
shorter_DFS
(Clinical Outcomes)
Original: High cytoplasmic Hsp27 expression#correlates with#shorter DFS in breast cancer patients
#18733
middle Confidence
Subject:
glassy_cell_carcinoma_of_the_uterine_cervix
(Tumor type)
→
associated_with
→
Object:
extrapelvic_spread
(Disease phenotype)
Original: glassy cell carcinoma of the uterine cervix#is associated with#extrapelvic spread in 6/13 cases at diagnosis
#18722
middle Confidence
Subject:
all_patients
(Patient population)
→
died_within
→
Object:
30_months_post_diagnosis
(Survival)
Original: all patients#died within#30 months post diagnosis
#18443
middle Confidence
Subject:
primary_malignant_melanoma_of_the_esophagus
(Malignant melanoma)
→
has
→
Object:
dismal_outcome
(Clinical Outcomes)
Original: primary malignant melanomas of the esophagus#have#a dismal outcome even in early-stage lesions amenable to surgical resection
#18201
middle Confidence
Subject:
Necrosis
(Histological characteristics)
→
is_observed_in
→
Object:
metastatic_prostate_carcinoma
(Tumor tissue)
Original: Frequent necrosis#is observed in#metastatic prostate carcinoma
#18169
middle Confidence
Subject:
SMARCA4_deep_deletion
(Gene deletion)
→
is_found_in
→
Object:
undifferentiated_carcinoma
(Tumor type)
Original: Three cases of undifferentiated or poorly differentiated carcinoma#had#SMARCA4 deep deletion or mutation discovered by next-generation sequencing
#18023
middle Confidence
Subject:
patient
(patient)
→
did_not_respond_well_to
→
Object:
chemotherapy
(Chemotherapy drugs)
Original: Patient#did not respond well to#chemotherapy and died 8 months after diagnosis
#17813
middle Confidence
Subject:
HCC_with_sarcomatous_features
(Hepatocellular carcinoma subtypes)
→
has_higher_incidence_of
→
Object:
metastasis
(Tumor metastasis)
Original: HCC with sarcomatous features#has#higher incidence of metastasis than usual HCC
#16327
middle Confidence
Subject:
Pancreatic_tumors_with_rhabdoid_features
(Tumor diseases)
→
have
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: Pancreatic tumors with rhabdoid features#have#characteristic histopathological features and poor prognosis
#16118
middle Confidence
Subject:
Patients
(patient)
→
died_of
→
Object:
disease
(disease)
Original: Patients#died of#disease following aggressive chemotherapeutic regimens
#15736
middle Confidence
Subject:
Growth_factors
(Growth Factors)
→
associated_with
→
Object:
biological_malignancy
(Tumor Biology Malignancy)
Original: Growth factors#might be related to#biological malignancy of tumors with high cell proliferation
#15548
middle Confidence
Subject:
epithelioid_rhabdomyosarcoma
(Tumor type)
→
metastasizes_to
→
Object:
lymph_node
(organize)
Original: A biopsy#encountered#epithelioid rhabdomyosarcoma with lymph node metastasis
#15232
middle Confidence
Subject:
neoplasm
(Tumor)
→
metastasized_to
→
Object:
lung
(lung)
Original: Neoplasm#presented with#distant metastases to bones/ pleura/ and lung
#15231
middle Confidence
Subject:
neoplasm
(Tumor)
→
metastasized_to
→
Object:
pleura
(pleura)
Original: Neoplasm#presented with#distant metastases to bones/ pleura/ and lung
#15230
middle Confidence
Subject:
neoplasm
(Tumor)
→
metastasized_to
→
Object:
bones
(Bone tissue)
Original: Neoplasm#presented with#distant metastases to bones/ pleura/ and lung
#13200
middle Confidence
Subject:
tumor
(Tumor)
→
behaved_like
→
Object:
advanced_malignancy
(Disease phenotype)
Original: tumor#behaved like#advanced malignancy
#12726
middle Confidence
Subject:
allograft_rejection_pathway
(signaling pathway)
→
is_upregulated_in
→
Object:
high_CAF_infiltration
(Tumor microenvironment characteristics)
Original: pathways such as allograft rejection/ epithelial-mesenchymal transition/ KRAS signaling#were upregulated in#patients with high CAF infiltration
#12123
middle Confidence
Subject:
reduced_KDM2B_level
(Reduced gene expression)
→
displays
→
Object:
aggressive_behavior_in_tumors
(Disease phenotype)
Original: Tumors with reduced KDM2A and KDM2B levels#display#aggressive behavior and increased nucleolar size
#12121
middle Confidence
Subject:
reduced_KDM2A_level
(Reduced gene expression)
→
displays
→
Object:
aggressive_behavior_in_tumors
(Disease phenotype)
Original: Tumors with reduced KDM2A and KDM2B levels#display#aggressive behavior and increased nucleolar size
#10516
middle Confidence
Subject:
patient
(patient)
→
died_of
→
Object:
systemic_carcinomatosis
(Cancer spreads throughout the body)
Original: Patient#died of#systemic carcinomatosis
#5837
middle Confidence
Subject:
patient
(patient)
→
developed
→
Object:
bone_metastasis
(Bone metastasis)
Original: Patient#developed#liver and bone metastases
#5836
middle Confidence
Subject:
patient
(patient)
→
developed
→
Object:
liver_metastasis
(Liver metastasis)
Original: Patient#developed#liver and bone metastases
#5371
middle Confidence
Subject:
neoplasm
(Tumor)
→
invades
→
Object:
adjacent_brain
(Organizational Structure)
Original: neoplasm#exhibited#papillary and solid areas with invasion of adjacent brain
#3730
low Confidence
Subject:
surgical_case
(Case)
→
manifested_with
→
Object:
lung_metastasis
(Disease phenotype)
Original: surgical case#manifested with#rapid lung metastasis
#2480
low Confidence
Subject:
GCOT
(Tumor)
→
exhibits
→
Object:
clinico-pathological_features_of_malignancy
(Disease phenotype)
Original: GCOT#exhibited#clinico-pathological features of malignancy
#1891
low Confidence
Subject:
glassy_cell_carcinoma_of_the_uterine_cervix
(Tumor type)
→
5-year_survival_rate
→
Object:
low_survival
(Survival Outcome)
Original: Only four of 13 patients#survived#5 years
#1890
low Confidence
Subject:
radiotherapy
(Treatment)
→
results_in
→
Object:
poor_outcome
(Clinical Outcomes)
Original: Results#were poor with#surgery and/or radiotherapy
#1889
low Confidence
Subject:
surgery
(Treatment)
→
results_in
→
Object:
poor_outcome
(Clinical Outcomes)
Original: Results#were poor with#surgery and/or radiotherapy
#1423
low Confidence
Subject:
Patient
(patient)
→
died_of
→
Object:
liver_metastasis
(Disease phenotype)
Original: Patient#died of#extensive skin involvement and spine and liver secondaries
#1422
low Confidence
Subject:
Patient
(patient)
→
died_of
→
Object:
spine_metastasis
(Disease phenotype)
Original: Patient#died of#extensive skin involvement and spine and liver secondaries
#1421
low Confidence
Subject:
Patient
(patient)
→
died_of
→
Object:
extensive_skin_involvement
(Disease phenotype)
Original: Patient#died of#extensive skin involvement and spine and liver secondaries