临床相关性：Preventive significance
A total of 38 records found
#19865
middle Confidence
Subject:
EGCG_sulindac_combination
(Drug combination regimen)
→
shows_synergy_in
→
Object:
cancer-preventive_activity
(Cancer prevention activity)
Original: EGCG and sulindac combination#shows#synergistic cancer-preventive activity in rat colon carcinogenesis
#19864
middle Confidence
Subject:
sulindac
(Nonsteroidal anti-inflammatory drugs)
→
shows
→
Object:
cancer-preventive_activity
(Cancer prevention activity)
Original: EGCG and sulindac combination#shows#synergistic cancer-preventive activity in rat colon carcinogenesis
#19863
middle Confidence
Subject:
EGCG
(Small molecule drugs)
→
shows
→
Object:
cancer-preventive_activity
(Cancer prevention activity)
Original: EGCG and sulindac combination#shows#synergistic cancer-preventive activity in rat colon carcinogenesis
#19744
middle Confidence
Subject:
Oral_contraceptives
(drug)
→
are_chemopreventive_in
→
Object:
Ovary
(organ)
Original: Oral contraceptives#are potentially#chemopreventive in the ovary
#18969
middle Confidence
Subject:
KYN-54
(Small organic molecules)
→
is
→
Object:
chemopreventive_agent_against_rat_colon_carcinogenesis
(Drug function)
Original: KYN-54#is#a chemopreventive agent against rat colon carcinogenesis
#18947
middle Confidence
Subject:
S_methyl_methane_thiosulfonate
(Compound)
→
prevents
→
Object:
azoxymethane_induced_colon_carcinogenesis
(Disease process)
Original: Dietary feeding of S-methyl methane thiosulfonate (MMTS)#prevents#azoxymethane-induced colon carcinogenesis
#18655
middle Confidence
Subject:
d-limonene
(Small molecule drugs)
→
inhibits
→
Object:
development_of_colonic_aberrant_crypt_foci
(Tumor development process)
Original: d-limonene#inhibited#development of colonic aberrant crypt foci
#18572
middle Confidence
Subject:
tea
(Natural Products)
→
has
→
Object:
chemopreventive_effects_on_human_oral_precancerous_mucosa_lesions
(Disease prevention)
Original: tea#has#chemopreventive effects on human oral precancerous mucosa lesions
#16729
middle Confidence
Subject:
KYN-5
(Small organic molecules)
→
modifies
→
Object:
development_of_AOM-induced_colonic_aberrant_crypt_foci
(Disease phenotype)
Original: KYN-5#modifies#development of AOM-induced colonic aberrant crypt foci
#16693
middle Confidence
Subject:
bone_marrow-derived_mesenchymal_stem_cells
(Mesenchymal stem cells)
→
play_a_role_in
→
Object:
reversion_of_gastric_precancerous_lesions
(Reversal of gastric precancerous lesions)
Original: Bone marrow-derived mesenchymal stem cells#play a role in#reversion of gastric precancerous lesions
#16687
middle Confidence
Subject:
S-methyl_methane_thiosulfonate
(Small organic molecules)
→
reduces
→
Object:
intestinal_neoplasm_incidence
(Tumor incidence)
Original: Incidence of intestinal neoplasms#was reduced in#a dose-dependent manner by MMTS
#16686
middle Confidence
Subject:
S-methyl_methane_thiosulfonate
(Small organic molecules)
→
reduces
→
Object:
colon_carcinogenesis
(Tumor development process)
Original: Feeding of MMTS#significantly decreased#number of aberrant crypt foci/colon
#16685
middle Confidence
Subject:
S-methyl_methane_thiosulfonate
(Small organic molecules)
→
reduces
→
Object:
aberrant_crypt_foci_number
(Preneoplastic phenotype)
Original: Feeding of MMTS#significantly decreased#number of aberrant crypt foci/colon
#16599
middle Confidence
Subject:
Flavonoids
(Natural compounds)
→
inhibit
→
Object:
bladder_carcinogenesis
(Tumor development process)
Original: Flavonoids#are effective in#inhibiting bladder carcinogenesis
#15877
middle Confidence
Subject:
atypical_hyperplasia
(Pathological tissue type)
→
fits_criteria_for
→
Object:
Chemoprevention
(Therapeutic interventions)
Original: Patients with atypical hyperplasia#fit#criteria for chemoprevention
#15876
middle Confidence
Subject:
CIN_patients
(Patient population)
→
fit_criteria_for
→
Object:
Chemoprevention
(Preventive interventions)
Original: Patients with cervical intraepithelial neoplasia (CIN)#fit#criteria for chemoprevention
#12085
middle Confidence
Subject:
LyP_patients
(Patient population)
→
have_predisposition_to
→
Object:
malignant_lymphomas
(Tumor diseases)
Original: LyP patients#have a predisposition to develop#malignant lymphomas
#12076
middle Confidence
Subject:
PCA
(Small molecule compounds)
→
could_be
→
Object:
chemopreventive_agent_against_colon_carcinogenesis
(Chemopreventive agents)
Original: PCA#could be#a chemopreventive agent against rat colon carcinogenesis
#12075
middle Confidence
Subject:
protocatechuic_acid
(Small molecule compounds)
→
decreases
→
Object:
frequency_of_ACF_in_colon
(Pathological phenotype)
Original: protocatechuic acid#decreased#frequency of ACF/colon in rats compared to AOM alone
#12074
middle Confidence
Subject:
protocatechuic_acid
(Small molecule compounds)
→
modifies
→
Object:
development_of_colonic_aberrant_crypt_foci
(Pathological process)
Original: dietary exposure to protocatechuic acid#modified#development of AOM-induced colonic aberrant crypt foci
#12038
middle Confidence
Subject:
PCA
(Natural Products)
→
suppresses
→
Object:
intermediate_biomarkers_induced_by_AOM
(Tumor intermediate biomarkers)
Original: PCA#suppresses#intermediate biomarkers induced by AOM during colon carcinogenesis
#11935
middle Confidence
Subject:
S-methyl_methane_thiosulfonate
(Small organic molecules)
→
reduces
→
Object:
aberrant_crypt_foci_number
(Preneoplastic phenotype)
Original: Feeding of MMTS#decreased#number of aberrant crypt foci/colon/ colonic ornithine decarboxylase activity/ and polyamine level in blood
#11929
middle Confidence
Subject:
chemopreventive_agent
(Drug function)
→
is_applied_for
→
Object:
colonic_carcinogenesis
(Disease process)
Original: d-limonene#is suggested as#a chemopreventive agent for colonic carcinogenesis
#11928
middle Confidence
Subject:
d-limonene
(Small molecule compounds)
→
is_suggested_as
→
Object:
chemopreventive_agent
(Drug function)
Original: d-limonene#is suggested as#a chemopreventive agent for colonic carcinogenesis
#11800
middle Confidence
Subject:
Green_tea_drinking
(Dietary behavior)
→
inhibits
→
Object:
ACF_formation
(Preneoplastic lesions)
Original: Green tea drinking#inhibited#ACF formation in rats
#11798
middle Confidence
Subject:
Green_tea
(Natural Products)
→
affects
→
Object:
colonic_aberrant_crypt_foci
(Pathological conditions)
Original: Green tea#affects#colonic aberrant crypt foci and proliferative indexes in rats
#11549
middle Confidence
Subject:
Oncogenic_factor
(Carcinogenic factors)
→
triggers
→
Object:
protective_response_against_proliferation_of_abnormal_cells
(Cellular Processes)
Original: Oncogenic factor overexpression#triggers#protective response against proliferation of abnormal cells
#11195
middle Confidence
Subject:
invasive_adenocarcinoma_of_the_cervix_uteri
(Tumor type)
→
could_be
→
Object:
preventable
(Prevention Attributes)
Original: invasive adenocarcinoma of the cervix uteri#could be#preventable
#10955
middle Confidence
Subject:
six_animals
(Experimental animals)
→
showed
→
Object:
pre-neoplastic_changes_of_biliary_duct_epithelium
(Biliary epithelial precancerous lesions)
Original: Six animals#showed#pre-neoplastic changes (hyperplasia and dysplasia) of the biliary duct epithelium
#10661
middle Confidence
Subject:
S-methyl_methane_thiosulfonate
(Small organic molecules)
→
modulates
→
Object:
intestinal_tumorigenesis
(Tumor development process)
Original: Effects of MMTS at two doses#were investigated on#intestinal tumorigenesis initiated with AOM
#10631
middle Confidence
Subject:
Feeding_of_test_compounds
(Experimental treatment)
→
reduces
→
Object:
bladder_carcinoma_frequency
(Disease incidence)
Original: Feeding of test compounds#caused#reduction in bladder carcinoma frequency
#9846
middle Confidence
Subject:
Epidemiological_data
(Epidemiological data)
→
shows
→
Object:
Chemopreventive_efficacy
(Drug prevention effect)
Original: Experimental or epidemiological data#show#chemopreventive efficacy
#9845
middle Confidence
Subject:
Experimental_data
(Experimental data)
→
shows
→
Object:
Chemopreventive_efficacy
(Drug prevention effect)
Original: Experimental or epidemiological data#show#chemopreventive efficacy
#7455
middle Confidence
Subject:
pre-neoplastic_changes_of_biliary_duct_epithelium
(Biliary epithelial precancerous lesions)
→
includes
→
Object:
dysplasia
(Dysplasia)
Original: Six animals#showed#pre-neoplastic changes (hyperplasia and dysplasia) of the biliary duct epithelium
#7454
middle Confidence
Subject:
pre-neoplastic_changes_of_biliary_duct_epithelium
(Biliary epithelial precancerous lesions)
→
includes
→
Object:
hyperplasia
(Hyperplasia)
Original: Six animals#showed#pre-neoplastic changes (hyperplasia and dysplasia) of the biliary duct epithelium
#6092
middle Confidence
Subject:
Green_tea_drinking
(Dietary behavior)
→
suppresses
→
Object:
cell_proliferation_in_intestinal_crypts
(Cellular Processes)
Original: Green tea drinking#is related to#suppression of cell proliferation in intestinal crypts
#6091
middle Confidence
Subject:
Green_tea
(Natural Products)
→
affects
→
Object:
proliferative_indexes_in_rats
(Cellular Processes)
Original: Green tea#affects#colonic aberrant crypt foci and proliferative indexes in rats
#2781
low Confidence
Subject:
S-methyl_methane_thiosulfonate
(Small organic molecules)
→
is_potential
→
Object:
chemopreventive_agent
(Chemopreventive agents)
Original: MMTS#might be#a possible chemopreventive agent for intestinal neoplasia