临床相关性：Prognosis
A total of 481 records found
#22201
high Confidence
Subject:
polymorphous_adenocarcinoma
(Tumor type)
→
is_associated_with
→
Object:
high_10-year_overall_survival_rate
(Clinical Outcomes)
Original: polymorphous adenocarcinoma#is associated with#a high 10-year overall survival rate (92.9%)
#22174
high Confidence
Subject:
malignant_tumors
(Tumor)
→
show
→
Object:
distant_metastasis
(Tumor metastasis phenotype)
Original: malignant tumors#show#venous or capsular invasion or distant metastasis
#22160
high Confidence
Subject:
Rhabdoid meningioma
(Tumor diseases)
→
is_described_as
→
Object:
aggressive tumor with recurrence risk
(Disease phenotype)
Original: Rhabdoid meningioma#is described as#rare/ WHO Grade III/ aggressive tumor with recurrence risk
#22155
high Confidence
Subject:
c-myc_amplification
(Gene amplification)
→
is_associated_with
→
Object:
poor_prognosis
(Poor prognosis)
Original: c-myc amplification#is associated with#poor prognosis
#22105
high Confidence
Subject:
NOP16
(Ribosomal proteins)
→
promotes
→
Object:
cancer_development
(Tumor development process)
Original: NOP16#promoted#cancer development in LIHC and caused an imbalance in Keap/Nrf2 signaling
#22103
high Confidence
Subject:
HPD
(protein)
→
inversely_correlates_with
→
Object:
overall_survival
(Survival Outcome)
Original: HPD expression level#is inversely correlated with#10-year overall survival rates in breast cancer
#22024
high Confidence
Subject:
cases
(Case)
→
showed
→
Object:
malignant_transformation
(Tumor progression)
Original: None of the cases#showed#malignant transformation to date
#21999
high Confidence
Subject:
Lymphatic_infiltration
(Tissue Microenvironment)
→
predictions
→
Object:
survival
(Survival Outcome)
Original: Lymphatic infiltration (LI)#predicts#survival in prostatic adenocarcinoma
#21989
high Confidence
Subject:
nucleolar_hTERT
(Telomerase reverse transcriptase)
→
correlates_with
→
Object:
malignancy_progression
(Tumor progression)
Original: Nucleolar or subnuclear hTERT#correlates directly with#recurrence and malignancy progression
#21988
high Confidence
Subject:
nucleolar_hTERT
(Telomerase reverse transcriptase)
→
correlates_with
→
Object:
recurrence
(Disease recurrence)
Original: Nucleolar or subnuclear hTERT#correlates directly with#recurrence and malignancy progression
#21984
high Confidence
Subject:
intraosseous_rhabdomyosarcoma
(Tumor subtype)
→
is
→
Object:
rare_aggressive_subtype
(Disease characteristics)
Original: intraosseous rhabdomyosarcoma#is#a rare aggressive subtype with predilection for gnathic bones
#21914
high Confidence
Subject:
Ewing_sarcoma/primitive_neuroectodermal_tumor
(Tumor)
→
is_highly_aggressive
→
Object:
aggressiveness
(Tumor phenotype)
Original: Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET)#is#a highly aggressive small round cell tumor
#21908
high Confidence
Subject:
pancreatic_mass
(Neoplastic lesions)
→
shows
→
Object:
liver_metastasis
(Metastatic lesions)
Original: 1 mass#had apparent#liver metastasis
#21852
high Confidence
Subject:
number_of_AgNORs
(Nucleolar organizing region count)
→
significantly_affected
→
Object:
4-year_survival_of_patients
(Survival)
Original: Number of AgNORs#significantly affected#4-year survival of patients
#21842
high Confidence
Subject:
leukemic_presentation
(Disease characteristics)
→
is_associated_with
→
Object:
very_poor_prognosis
(Prognosis)
Original: Prognosis#is#very poor for ALCL with leukemic presentation
#21794
high Confidence
Subject:
SCNEC
(Tumor)
→
has_high_propensity_for
→
Object:
distant_metastasis
(Metastatic phenotype)
Original: Small cell neuroendocrine carcinoma (SCNEC)#has#a high propensity for distant metastases
#21793
high Confidence
Subject:
SCNEC
(Tumor)
→
is_associated_with
→
Object:
poor_prognosis
(Prognosis)
Original: Small cell neuroendocrine carcinoma (SCNEC)#is#a rare/ highly aggressive tumor with poor prognosis
#21792
high Confidence
Subject:
SCNEC
(Tumor)
→
is
→
Object:
rare_highly_aggressive_tumor
(Tumor phenotype)
Original: Small cell neuroendocrine carcinoma (SCNEC)#is#a rare/ highly aggressive tumor with poor prognosis
#21781
high Confidence
Subject:
CCND1_copy_number_gain
(Genomic changes)
→
is_associated_with
→
Object:
poor_prognosis
(Disease phenotype)
Original: increased copy number gains in 11q (cyclin D1)#is associated with#poor prognosis in melanoma
#21759
high Confidence
Subject:
MYCN-amplified tumors
(MYCN-amplified tumors)
→
shows
→
Object:
poorly differentiated neuroblastoma subtype
(Poorly differentiated neuroblastoma subtypes)
Original: MYCN-amplified tumors#typically show#poorly differentiated neuroblastoma subtype
#21755
high Confidence
Subject:
large_cell_NEC
(Tumor cell subtype)
→
is_associated_with
→
Object:
very_poor_prognosis
(Disease Prognosis)
Original: large cell NEC#is associated with#a very poor prognosis (median survival time/ 15.2 months; 1-year survival rate/ 58%)
#21710
high Confidence
Subject:
very_large_prominent_nucleoli
(Nuclear morphology)
→
predictions
→
Object:
cancer
(Neoplastic diseases)
Original: very large prominent nucleoli#predict#cancer
#21601
high Confidence
Subject:
NPM_C-terminal_mutation
(Gene mutation)
→
is_associated_with
→
Object:
better_outcome_of_AML_therapy
(Clinical Outcomes)
Original: Mutations in C-terminal part of NPM#are associated with#better outcome of AML therapy
#21540
high Confidence
Subject:
AgNORs
(Nucleolar organizer region)
→
are_crucial_for
→
Object:
prediction_of_clinical_course_and_aggressiveness_of_tumors
(Prediction of clinical progression of tumors)
Original: AgNORs#are crucial for#predicting the clinical course and aggressiveness of tumors
#21532
high Confidence
Subject:
AgNORs
(Nucleolar Organizing Region Marker)
→
is_lower_in
→
Object:
surgical_patients_surviving_over_5_years
(Clinical Outcome (Long-term Survival))
Original: PI and AgNORs image analysis results#are significantly lower in#surgical patients surviving over 5 years compared to those surviving less than 3 years
#21531
high Confidence
Subject:
proliferation_index
(Proliferation activity index)
→
is_lower_in
→
Object:
surgical_patients_surviving_over_5_years
(Clinical Outcome (Long-term Survival))
Original: PI and AgNORs image analysis results#are significantly lower in#surgical patients surviving over 5 years compared to those surviving less than 3 years
#21500
high Confidence
Subject:
prominent_nucleoli
(Cell structure)
→
is_identified_as
→
Object:
independent_risk_factor_for_disease-free_survival
(Clinical Outcomes)
Original: The presence of prominent nucleoli#was identified as#an independent risk factor for disease-free survival
#21499
high Confidence
Subject:
high_clinical_stage
(Clinical staging)
→
is_identified_as
→
Object:
independent_risk_factor_for_disease-free_survival
(Clinical Outcomes)
Original: High clinical stage#was identified as#an independent risk factor for disease-free survival
#21408
high Confidence
Subject:
granular_cell_tumors
(Tumor)
→
classified_as
→
Object:
non_benign
(Disease phenotype)
Original: spindling of tumor cells/ necrosis/ diffuse pleomorphism/ prominent nucleoli/ high nuclear-cytoplasmic ratio/ and mitotic rate >2 per 10 high-power fields#classify#GCTs as non-benign
#21393
high Confidence
Subject:
pathologic_staging
(Pathological staging)
→
is_important_for
→
Object:
determining_clinical_outcomes
(Clinical Outcomes)
Original: Clinical and pathologic staging of mediastinal seminomas#are important for#determining clinical outcomes
#21392
high Confidence
Subject:
clinical_staging
(Clinical staging)
→
is_important_for
→
Object:
determining_clinical_outcomes
(Clinical Outcomes)
Original: Clinical and pathologic staging of mediastinal seminomas#are important for#determining clinical outcomes
#21387
high Confidence
Subject:
AgNOR_distribution
(Molecular pathology indicators)
→
is_used_for
→
Object:
tumor_prognosis
(Tumor prognosis)
Original: AgNOR distribution#is used for#diagnostic and prognostic purposes of tumors
#21382
high Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar organizer region)
→
acts_as
→
Object:
prognostic_indicator
(Prognostic indicators)
Original: Nucleolar organizer regions#act as#a prognostic indicator for stage I non-small cell lung cancer
#21129
high Confidence
Subject:
open_chromatin
(Chromatin open state)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: open chromatin#is identified as#adverse prognostic factor of RFS
#21128
high Confidence
Subject:
nuclear_atypia
(Nuclear atypia in tumor cells)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: nuclear atypia#is identified as#adverse prognostic factor of RFS
#21127
high Confidence
Subject:
vascular_invasion
(Tumor vascular invasion)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: vascular invasion#is identified as#adverse prognostic factor of RFS
#21126
high Confidence
Subject:
high_grade_transformation
(Tumor grade characteristics)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: high-grade transformation#is identified as#adverse prognostic factor of RFS
#21125
high Confidence
Subject:
positive_margin
(Surgical margin characteristics)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: positive margin#is identified as#adverse prognostic factor of RFS
#21124
high Confidence
Subject:
increased_mitoses
(Tumor cell proliferation characteristics)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: increased mitoses#is identified as#adverse prognostic factor of RFS
#21123
high Confidence
Subject:
solid_growth_pattern
(Tumor Histological Characteristics)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: solid growth pattern#is identified as#adverse prognostic factor of RFS
#21122
high Confidence
Subject:
large_tumor_size
(Tumor phenotypic characteristics)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: large tumor size#is identified as#adverse prognostic factor of RFS
#21086
high Confidence
Subject:
Stage_III_or_IV_disease
(Patient stratification)
→
is_associated_with
→
Object:
patient_death
(Disease phenotype)
Original: Stage III or IV disease#is significantly associated with#tumor recurrence or patient's death
#21085
high Confidence
Subject:
Stage_III_or_IV_disease
(Patient stratification)
→
is_associated_with
→
Object:
tumor_recurrence
(Disease phenotype)
Original: Stage III or IV disease#is significantly associated with#tumor recurrence or patient's death
#21084
high Confidence
Subject:
older_age
(Age Factor)
→
is_significantly_associated_with
→
Object:
patient_death
(Disease Outcome)
Original: Older age#is significantly associated with#tumor recurrence or patient's death
#21083
high Confidence
Subject:
older_age
(Age Factor)
→
is_significantly_associated_with
→
Object:
tumor_recurrence
(Disease Outcome)
Original: Older age#is significantly associated with#tumor recurrence or patient's death
#20975
high Confidence
Subject:
IMTCGS
(Molecular detection indicators)
→
has
→
Object:
prognostic_significance
(Prognostic significance)
Original: IMTCGS#has#prognostic significance
#20934
high Confidence
Subject:
malignant_tumors
(Tumor)
→
show
→
Object:
capsular_invasion
(Tumor invasion phenotype)
Original: malignant tumors#show#venous or capsular invasion or distant metastasis
#20933
high Confidence
Subject:
malignant_tumors
(Tumor)
→
show
→
Object:
venous_invasion
(Tumor invasion phenotype)
Original: malignant tumors#show#venous or capsular invasion or distant metastasis
#20859
high Confidence
Subject:
Rhabdoid meningioma
(Tumor diseases)
→
is_described_as
→
Object:
WHO Grade III
(Disease classification)
Original: Rhabdoid meningioma#is described as#rare/ WHO Grade III/ aggressive tumor with recurrence risk
#20858
high Confidence
Subject:
Rhabdoid meningioma
(Tumor diseases)
→
is_described_as
→
Object:
rare tumor
(Disease phenotype)
Original: Rhabdoid meningioma#is described as#rare/ WHO Grade III/ aggressive tumor with recurrence risk
#20808
high Confidence
Subject:
unusual_RCC
(Disease classification)
→
shows
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: unusual RCC#shows#rhabdoid morphology and poor prognosis
#20746
high Confidence
Subject:
tumors
(Tumor tissue)
→
are_reported_as
→
Object:
malignant
(Tumor phenotype)
Original: tumors#are reported as#malignant in most cases
#20738
high Confidence
Subject:
sub-typing_system
(Diagnostic Tools)
→
is_suitable_for
→
Object:
predicting_postoperative_outcome_in_stage_I_lung_adenocarcinoma
(Clinical Outcomes)
Original: sub-typing system#is suitable for#predicting postoperative outcome in stage I lung adenocarcinoma
#20659
high Confidence
Subject:
maxillofacial_neuroendocrine_carcinoma
(Tumor)
→
characterized_by
→
Object:
poor_prognosis
(Prognostic features)
Original: Maxillofacial neuroendocrine carcinoma#is characterized by#low differentiation/ high malignancy/ and poor prognosis
#20658
high Confidence
Subject:
maxillofacial_neuroendocrine_carcinoma
(Tumor)
→
characterized_by
→
Object:
high_malignancy
(Tumor phenotype)
Original: Maxillofacial neuroendocrine carcinoma#is characterized by#low differentiation/ high malignancy/ and poor prognosis
#20657
high Confidence
Subject:
maxillofacial_neuroendocrine_carcinoma
(Tumor)
→
characterized_by
→
Object:
low_differentiation
(Tumor phenotype)
Original: Maxillofacial neuroendocrine carcinoma#is characterized by#low differentiation/ high malignancy/ and poor prognosis
#20617
high Confidence
Subject:
patients
(patient)
→
presented_with
→
Object:
lymph_node_metastases
(Disease phenotype)
Original: Patients#presented with#multiple lymph node metastases
#20584
high Confidence
Subject:
nucleolar_size
(Cell structure phenotype)
→
is
→
Object:
prognostic_measure_of_cancer_disease_severity
(Prognostic indicators)
Original: Nucleolar size#is#a prognostic measure of cancer disease severity
#20578
high Confidence
Subject:
LINC01572_overexpression
(lncRNA expression status)
→
is_associated_with
→
Object:
shorter_overall_survival
(Clinical Outcomes)
Original: LINC01572 overexpression#is associated with#shorter overall survival in LUAD
#20514
high Confidence
Subject:
PROX1
(Transcription Factors)
→
plays_important_role_in
→
Object:
cancer_metastasis
(Tumor development process)
Original: PROX1#plays an important role in#invasion and metastasis of many human cancers
#20513
high Confidence
Subject:
PROX1
(Transcription Factors)
→
plays_important_role_in
→
Object:
cancer_invasion
(Tumor development process)
Original: PROX1#plays an important role in#invasion and metastasis of many human cancers
#20489
high Confidence
Subject:
cell_proliferation
(Cellular Processes)
→
increases_as
→
Object:
HCC_progression
(Disease progression)
Original: Cell proliferation#increases as#HCC progresses
#20482
high Confidence
Subject:
AgNOR_protein
(Protein complex)
→
has
→
Object:
prognostic_significance
(Prognostic significance)
Original: AgNOR proteins#have#prognostic significance in stage II-III rectal cancers
#20420
high Confidence
Subject:
NCL
(Ribosomal proteins)
→
correlates_with
→
Object:
iCCA_progression
(Disease phenotype)
Original: Nucleolin#correlates with#iCCA occurrence and progression
#20358
high Confidence
Subject:
HPSE
(Hydrolases)
→
correlates_with
→
Object:
cancer_metastasis
(Tumor metastasis)
Original: Heparanase#correlates with#cancer metastasis
#20350
high Confidence
Subject:
ALK
(Receptor tyrosine kinases)
→
overexpression_is_associated_with
→
Object:
good_prognosis
(Prognosis)
Original: p80/ALK overexpression#is associated with#a good prognosis in t(2:5)-positive tumors
#20101
high Confidence
Subject:
tubular_adenocarcinoma
(Tumor type)
→
shows
→
Object:
well_differentiated
(Differentiation level)
Original: endoscopic submucosal dissection#revealed#tubular adenocarcinoma/ well-differentiated/ with slight submucosal invasion
#20080
high Confidence
Subject:
p53_expression
(Protein expression)
→
is_useful_as
→
Object:
prognostic_indicator
(Clinical outcome measures)
Original: DNA ploidy and p53 expression#are useful as#prognostic indicators in HCC
#20079
high Confidence
Subject:
DNA_ploidy
(Genomic features)
→
is_useful_as
→
Object:
prognostic_indicator
(Clinical outcome measures)
Original: DNA ploidy and p53 expression#are useful as#prognostic indicators in HCC
#20044
high Confidence
Subject:
patients_with_pancreatic_cancer
(Patient population)
→
develop
→
Object:
cachexia
(Disease phenotype)
Original: patients with pancreatic cancer#develops#cachexia
#20030
high Confidence
Subject:
Cyclin_D1
(Cell cycle proteins)
→
is_unique_prognostic_marker_for
→
Object:
human_HCC
(Disease phenotype)
Original: Cyclin D1 immunostaining#is a unique prognostic marker for#human HCC
#20027
high Confidence
Subject:
SNORA23_level_in_PDAC
(Noncoding RNA)
→
inversely_correlated_with
→
Object:
disease-free_survival
(Clinical Outcomes)
Original: SNORA23 level in PDAC#correlated with#invasion grade and inversely with disease-free survival
#20026
high Confidence
Subject:
SNORA23_level_in_PDAC
(Noncoding RNA)
→
correlated_with
→
Object:
invasion_grade
(Pathological grading)
Original: SNORA23 level in PDAC#correlated with#invasion grade and inversely with disease-free survival
#19985
middle Confidence
Subject:
AgNOR_counts
(Nucleolar organizer-associated region counts)
→
were_higher_in
→
Object:
poorly_differentiated_adenocarcinomas
(Poorly differentiated adenocarcinoma)
Original: AgNOR counts#were higher in#tumors from advanced stages or poorly differentiated adenocarcinomas
#19984
middle Confidence
Subject:
AgNOR_counts
(Nucleolar organizer-associated region counts)
→
were_higher_in
→
Object:
advanced_stage_tumors
(Advanced tumors)
Original: AgNOR counts#were higher in#tumors from advanced stages or poorly differentiated adenocarcinomas
#19974
middle Confidence
Subject:
NUT carcinoma
(Solid Tumors)
→
remains
→
Object:
very_poor_prognosis_with_median_survival_6.7_months
(Clinical Outcomes)
Original: Prognosis of NUT carcinoma#remains#very poor with median survival of 6.7 months
#19971
middle Confidence
Subject:
Nucleolar_organizer_regions
(Nucleolar organizing region)
→
are_predictors_for
→
Object:
recurrence
(Tumor recurrence)
Original: Mitotic count and nucleolar organizer regions#appeared as#best predictors for recurrence
#19946
middle Confidence
Subject:
AgNOR_count
(Molecular markers)
→
is_prognostic_factor_for
→
Object:
recurrent_soft_tissue_sarcoma
(Tumor diseases)
Original: AgNOR counts#can be used as#a prognostic factor in recurrent STS
#19944
middle Confidence
Subject:
metastasis
(Tumor metastasis)
→
influenced
→
Object:
survival
(Survival)
Original: Number of positive axillary lymph nodes and metastasis#influenced#survival
#19943
middle Confidence
Subject:
number_of_positive_axillary_lymph_nodes
(Lymph node count)
→
influenced
→
Object:
survival
(Survival)
Original: Number of positive axillary lymph nodes and metastasis#influenced#survival
#19941
middle Confidence
Subject:
mitotic_count
(Cell phenotype)
→
serves_as
→
Object:
independent_prognostic_factor
(Disease phenotype)
Original: nuclear atypia and mitotic count#serve as#independent prognostic factors
#19940
middle Confidence
Subject:
nuclear_atypia
(Cell phenotype)
→
serves_as
→
Object:
independent_prognostic_factor
(Disease phenotype)
Original: nuclear atypia and mitotic count#serve as#independent prognostic factors
#19921
middle Confidence
Subject:
GNA11_mutant_tumor
(Tumor)
→
is_associated_with
→
Object:
poorer_disease_specific_survival
(Clinical Outcomes)
Original: GNA11-mutant tumors#had#poorer disease-specific survival than wild-type tumors
#19919
middle Confidence
Subject:
NAT10
(protein)
→
may_be
→
Object:
prognostic_marker
(Biomarkers)
Original: NAT10#may be#a prognostic marker and potential therapeutic target
#19909
middle Confidence
Subject:
NORa_TNa_value
(Molecular analysis parameters)
→
negatively_correlates_with
→
Object:
disease_free_survival
(Clinical Outcomes)
Original: NORa/TNa value#negatively correlates with#overall survival and disease-free survival
#19908
middle Confidence
Subject:
NORa_TNa_value
(Molecular analysis parameters)
→
negatively_correlates_with
→
Object:
overall_survival
(Clinical Outcomes)
Original: NORa/TNa value#negatively correlates with#overall survival and disease-free survival
#19887
middle Confidence
Subject:
DKC1
(Ribosome modifying enzymes)
→
is_associated_with
→
Object:
tumor_progression
(Tumor progression)
Original: Dyskerin function#is associated with#tumor progression
#19855
middle Confidence
Subject:
NOR_index
(Nucleolar Organizer Zone Index)
→
has_prognostic_value_in
→
Object:
neoplastic_disease
(Neoplastic diseases)
Original: NOR index#correlates with#cellular proliferation and has diagnostic and prognostic value in neoplastic disease
#19852
middle Confidence
Subject:
Apaf-1_expression
(Protein expression)
→
positively_correlates_with
→
Object:
reduced_survival
(Clinical Outcomes)
Original: Apaf-1 expression#is positively correlated with#reduced survival in colon adenocarcinoma patients
#19843
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
is_adequate_parameter_to_predict
→
Object:
lesion_outcome
(Disease outcome)
Original: Tumor stage and grade#were deemed as#adequate parameters to predict lesion outcome
#19842
middle Confidence
Subject:
tumor_stage
(Tumor stage)
→
is_adequate_parameter_to_predict
→
Object:
lesion_outcome
(Disease outcome)
Original: Tumor stage and grade#were deemed as#adequate parameters to predict lesion outcome
#19832
middle Confidence
Subject:
pancreatic_acinar-like_adenocarcinoma_group
(Tumor subtype)
→
associated_with
→
Object:
worse_overall_survival_trend
(Clinical Outcomes)
Original: Pancreatic acinar-like adenocarcinoma group#had#a worse overall survival trend
#19826
middle Confidence
Subject:
Renal_cell_carcinoma_with_sarcomatoid_morphology
(Tumor type)
→
has
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: Renal cell carcinoma (RCC) with sarcomatoid and rhabdoid morphologies#has#aggressive biological behavior and typically poor prognosis
#19825
middle Confidence
Subject:
Renal_cell_carcinoma_with_sarcomatoid_morphology
(Tumor type)
→
has
→
Object:
aggressive_biological_behavior
(Disease phenotype)
Original: Renal cell carcinoma (RCC) with sarcomatoid and rhabdoid morphologies#has#aggressive biological behavior and typically poor prognosis
#19824
middle Confidence
Subject:
Inflammatory_monomorphic_undifferentiated_sarcoma
(Tumor type)
→
is
→
Object:
highly_aggressive_malignancy
(Disease phenotype)
Original: Inflammatory monomorphic undifferentiated sarcoma#is#a highly aggressive malignancy
#19819
middle Confidence
Subject:
oncocytic_carcinoma
(Tumor type)
→
is_associated_with
→
Object:
complete_surgical_excision
(Surgery)
Original: Prognosis of oncocytic carcinoma#is associated with#tumor stage/ regional lymph node metastases/ and complete surgical excision
#19818
middle Confidence
Subject:
oncocytic_carcinoma
(Tumor type)
→
is_associated_with
→
Object:
regional_lymph_node_metastasis
(Tumor metastasis)
Original: Prognosis of oncocytic carcinoma#is associated with#tumor stage/ regional lymph node metastases/ and complete surgical excision
#19817
middle Confidence
Subject:
oncocytic_carcinoma
(Tumor type)
→
is_associated_with
→
Object:
tumor_stage
(Tumor stage)
Original: Prognosis of oncocytic carcinoma#is associated with#tumor stage/ regional lymph node metastases/ and complete surgical excision
#19816
middle Confidence
Subject:
oncocytic_carcinoma_case
(Tumor Cases)
→
survived_without
→
Object:
distant_metastasis
(Tumor metastasis)
Original: 7 cases#survived without#region or distant metastases
#19815
middle Confidence
Subject:
oncocytic_carcinoma_case
(Tumor Cases)
→
survived_without
→
Object:
regional_metastasis
(Tumor metastasis)
Original: 7 cases#survived without#region or distant metastases
#19802
middle Confidence
Subject:
PEComas
(Tumor type)
→
are_associated_with
→
Object:
potential_for_recurrence
(Disease phenotype)
Original: PEComas#are associated with#potential for recurrence
#19777
middle Confidence
Subject:
AgNORs
(Nucleolar organizing region)
→
is_examined_for
→
Object:
long-term_prognostic_value
(Prognostic significance)
Original: GST-pi and AgNORs#are examined for#long-term prognostic value in CDDP therapy
#19776
middle Confidence
Subject:
GST-pi
(Enzymes)
→
is_examined_for
→
Object:
long-term_prognostic_value
(Prognostic significance)
Original: GST-pi and AgNORs#are examined for#long-term prognostic value in CDDP therapy
#19775
middle Confidence
Subject:
HPD
(Enzymes)
→
is_correlated_with
→
Object:
prognosis
(Prognosis)
Original: HPD expression#is correlated with#prognosis in patients with breast cancer
#19774
middle Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar organizing region)
→
have
→
Object:
prognostic_significance
(Prognostic significance)
Original: Nucleolar organizer regions#have#prognostic significance in recurrent pleomorphic adenomas of salivary glands
#19764
middle Confidence
Subject:
Cancer_cell_nuclei
(Cancer cell nucleus)
→
proved_to_be
→
Object:
independent_prognostic_predictor
(Prognostic predictors)
Original: Density of cancer cell nuclei#proved to be#an independent prognostic predictor
#19749
middle Confidence
Subject:
MIB-1_proliferation_index
(Cell proliferation markers)
→
correlates_with
→
Object:
neoplasm_malignancy_grade
(Tumor grade)
Original: MIB-1 proliferation index#correlates with#neoplasm malignancy grade
#19748
middle Confidence
Subject:
AgNOR_number
(NOR)
→
correlates_with
→
Object:
neoplasm_malignancy_grade
(Tumor grade)
Original: Number of AgNORs#correlates with#neoplasm malignancy grade
#19683
middle Confidence
Subject:
PCNA
(Proliferating cell nuclear antigen)
→
correlates_with
→
Object:
tumor_aggressiveness
(Tumor aggressiveness)
Original: Staining intensity of p53/ Ki67/ and PCNA markers#correlates with#proliferative activity and tumor aggressiveness
#19682
middle Confidence
Subject:
PCNA
(Proliferating cell nuclear antigen)
→
correlates_with
→
Object:
proliferative_activity
(Proliferation activity)
Original: Staining intensity of p53/ Ki67/ and PCNA markers#correlates with#proliferative activity and tumor aggressiveness
#19681
middle Confidence
Subject:
Ki67
(Cell proliferation antigen)
→
correlates_with
→
Object:
tumor_aggressiveness
(Tumor aggressiveness)
Original: Staining intensity of p53/ Ki67/ and PCNA markers#correlates with#proliferative activity and tumor aggressiveness
#19680
middle Confidence
Subject:
Ki67
(Cell proliferation antigen)
→
correlates_with
→
Object:
proliferative_activity
(Proliferation activity)
Original: Staining intensity of p53/ Ki67/ and PCNA markers#correlates with#proliferative activity and tumor aggressiveness
#19679
middle Confidence
Subject:
p53
(Tumor suppressor proteins)
→
correlates_with
→
Object:
tumor_aggressiveness
(Tumor aggressiveness)
Original: Staining intensity of p53/ Ki67/ and PCNA markers#correlates with#proliferative activity and tumor aggressiveness
#19678
middle Confidence
Subject:
p53
(Tumor suppressor proteins)
→
correlates_with
→
Object:
proliferative_activity
(Proliferation activity)
Original: Staining intensity of p53/ Ki67/ and PCNA markers#correlates with#proliferative activity and tumor aggressiveness
#19645
middle Confidence
Subject:
rhabdoid_feature_positive_tumor
(Tumor type)
→
is_associated_with
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: Tumors showing rhabdoid features#are associated with#a poor prognosis
#19584
middle Confidence
Subject:
malignant_rhabdoid_tumors_of_the_spine
(Tumor)
→
have
→
Object:
poor_prognosis
(Prognosis)
Original: Malignant rhabdoid tumors of the spine#have#a poor prognosis
#19577
middle Confidence
Subject:
molecular_findings_in_tumor_samples
(Molecular test results)
→
correlates_with
→
Object:
prognosis
(Clinical Outcomes)
Original: Molecular findings in tumor samples#correlated with#prognosis and histopathologic tumor characteristics
#19567
middle Confidence
Subject:
AgNOR
(Molecular markers)
→
shows
→
Object:
increased_proliferative_activity
(Cellular Processes)
Original: AgNOR#showed#increased proliferative activity in recurrent tumors
#19528
middle Confidence
Subject:
LHS
(disease)
→
have
→
Object:
liver_metastasis
(Disease phenotype)
Original: Most LHS cases#have#liver metastasis due to bypass of first-pass liver metabolism
#19526
middle Confidence
Subject:
IDH2_wild_type
(genotype)
→
is_associated_with
→
Object:
worse_disease_specific_survival
(Clinical Outcomes)
Original: IDH2 mutants#showed#better disease-specific survival than SMARCB1-deficient and IDH2 wild-type carcinomas
#19525
middle Confidence
Subject:
SMARCB1_deficient
(genotype)
→
is_associated_with
→
Object:
worse_disease_specific_survival
(Clinical Outcomes)
Original: IDH2 mutants#showed#better disease-specific survival than SMARCB1-deficient and IDH2 wild-type carcinomas
#19524
middle Confidence
Subject:
IDH2_mutant
(genotype)
→
is_associated_with
→
Object:
better_disease_specific_survival
(Clinical Outcomes)
Original: IDH2 mutants#showed#better disease-specific survival than SMARCB1-deficient and IDH2 wild-type carcinomas
#19513
middle Confidence
Subject:
rhabdoid phenotype in gastrointestinal neoplasms
(Tumor subtype)
→
is_associated_with
→
Object:
poor prognosis
(Prognosis)
Original: rhabdoid phenotype in gastrointestinal neoplasms#is associated with#poor prognosis and unresponsiveness to therapy
#19511
middle Confidence
Subject:
comedo-like_necrosis
(Tissue morphology)
→
is_associated_with
→
Object:
patient_death
(Disease phenotype)
Original: Comedo-like necrosis#is significantly associated with#tumor recurrence or patient's death
#19510
middle Confidence
Subject:
comedo-like_necrosis
(Tissue morphology)
→
is_associated_with
→
Object:
tumor_recurrence
(Disease phenotype)
Original: Comedo-like necrosis#is significantly associated with#tumor recurrence or patient's death
#19509
middle Confidence
Subject:
fibroblastic_proliferation
(Cellular Processes)
→
is_associated_with
→
Object:
patient_death
(Disease phenotype)
Original: Active fibroblastic proliferation#is significantly associated with#tumor recurrence or patient's death
#19508
middle Confidence
Subject:
fibroblastic_proliferation
(Cellular Processes)
→
is_associated_with
→
Object:
tumor_recurrence
(Disease phenotype)
Original: Active fibroblastic proliferation#is significantly associated with#tumor recurrence or patient's death
#19507
middle Confidence
Subject:
prominent_nucleoli
(Nuclear morphology)
→
identify
→
Object:
unfavorable_tumor_biology
(Tumor Biological Characteristics)
Original: prominent nucleoli#identify#unfavorable tumor biology
#19496
middle Confidence
Subject:
p16(INK4)/CDKN2A
(Cell cycle regulatory genes)
→
may_play
→
Object:
progression_of_leptomeningeal_melanocytic_neoplasms
(Disease progression)
Original: p16(INK4)/CDKN2#may play#a significant role in progression of leptomeningeal melanocytic neoplasms
#19480
middle Confidence
Subject:
malignant_blue_nevus
(Tumor tissue)
→
is_associated_with
→
Object:
metastasis
(Tumor metastasis)
Original: malignant blue nevus#is associated with#metastasis
#19464
middle Confidence
Subject:
CD5_positive_DLBCL
(Tumor subtype)
→
is_associated_with
→
Object:
poor_prognosis
(Prognosis)
Original: Patients with CD5+ DLBCL#showed#a high age of onset and poor prognosis
#19463
middle Confidence
Subject:
CD5_positive_DLBCL
(Tumor subtype)
→
is_associated_with
→
Object:
high_age_of_onset
(Clinical characteristics)
Original: Patients with CD5+ DLBCL#showed#a high age of onset and poor prognosis
#19448
middle Confidence
Subject:
KI67
(Cell proliferation markers)
→
associated_with
→
Object:
poor_DMFRS
(Prognostic indicators)
Original: High grade/ Ki67% and coagulative necrosis#are associated with#poor DMFRS and OS
#19447
middle Confidence
Subject:
high_grade
(Tumor grade)
→
associated_with
→
Object:
poor_DMFRS
(Prognostic indicators)
Original: High grade/ Ki67% and coagulative necrosis#are associated with#poor DMFRS and OS
#19446
middle Confidence
Subject:
HG_patients
(Patient classification)
→
showed
→
Object:
distant_metastasis
(Metastatic phenotype)
Original: HG patients#showed#distant metastasis
#19443
middle Confidence
Subject:
angiogenic_factor_expression
(Angiogenic factor expression)
→
is_prognostic_for
→
Object:
lymph_node_metastasis
(Metastatic phenotype)
Original: nuclear morphometry and angiogenic factor expression#are useful prognostic markers#for lymph node metastasis
#19442
middle Confidence
Subject:
nuclear_morphometry
(Nuclear morphology)
→
is_prognostic_for
→
Object:
lymph_node_metastasis
(Metastatic phenotype)
Original: nuclear morphometry and angiogenic factor expression#are useful prognostic markers#for lymph node metastasis
#19428
middle Confidence
Subject:
adenocarcinoma_of_the_pancreas
(Tumor diseases)
→
has
→
Object:
worse_prognosis_than_primary_pancreatic_lymphomas
(Disease Prognosis)
Original: Primary pancreatic lymphomas#have#a much better prognosis than adenocarcinoma of the pancreas
#19427
middle Confidence
Subject:
Primary_pancreatic_lymphomas
(Tumor diseases)
→
have
→
Object:
much_better_prognosis_than_adenocarcinoma_of_the_pancreas
(Disease Prognosis)
Original: Primary pancreatic lymphomas#have#a much better prognosis than adenocarcinoma of the pancreas
#19378
middle Confidence
Subject:
Peripheral_neuroepithelioma
(Tumor type)
→
is_a
→
Object:
malignant_primitive_neuroectodermal_tumor
(Tumor type)
Original: Peripheral neuroepithelioma#is#a malignant primitive neuroectodermal tumor with poor outcome
#19335
middle Confidence
Subject:
large_cell_neuroblastoma
(Tumor type)
→
is_associated_with
→
Object:
aggressive_clinical_behavior
(Disease phenotype)
Original: large cell neuroblastoma#is#a distinct phenotype of neuroblastoma with aggressive behavior
#19314
middle Confidence
Subject:
histological_architecture
(Organizational Structure)
→
has
→
Object:
prognostic_value_in_lung_adenocarcinoma
(Prognostic value)
Original: histological architecture#has#prognostic value in lung adenocarcinoma
#19313
middle Confidence
Subject:
postoperative_disease_recurrence
(Disease phenotype)
→
is_associated_with
→
Object:
chromatin_pattern
(Cell morphology)
Original: postoperative disease recurrence#is associated with#nucleoli count and chromatin pattern
#19312
middle Confidence
Subject:
postoperative_disease_recurrence
(Disease phenotype)
→
is_associated_with
→
Object:
nucleoli_count
(Cell morphology)
Original: postoperative disease recurrence#is associated with#nucleoli count and chromatin pattern
#19289
middle Confidence
Subject:
T-cell_lineage_case
(Patient classification)
→
has
→
Object:
median_survival_time_1_month
(Clinical Outcomes)
Original: T-cell lineage cases#had#a median survival time of 1 month
#19269
middle Confidence
Subject:
high_grade_nuclei
(Nuclear characteristics)
→
showed
→
Object:
death
(die)
Original: High-grade nuclei#showed#disease progression or death
#19268
middle Confidence
Subject:
high_grade_nuclei
(Nuclear characteristics)
→
showed
→
Object:
disease_progression
(Disease progression)
Original: High-grade nuclei#showed#disease progression or death
#19238
middle Confidence
Subject:
patients_with_atypical_glands
(Patient characteristics)
→
require
→
Object:
close_monitoring
(Clinical management measures)
Original: patients with atypical glands suspicious for carcinoma#are subject to#close monitoring and repeat biopsies
#19230
middle Confidence
Subject:
microsatellitosis
(Tumor phenotype)
→
was_strongly_correlated_with
→
Object:
polynucleolization
(Nucleolar phenotype)
Original: Microsatellitosis#was strongly correlated with#presence of macronucleoli and polynucleolization
#19229
middle Confidence
Subject:
microsatellitosis
(Tumor phenotype)
→
was_strongly_correlated_with
→
Object:
presence_of_macronucleoli
(Nucleolar phenotype)
Original: Microsatellitosis#was strongly correlated with#presence of macronucleoli and polynucleolization
#19205
middle Confidence
Subject:
LINC01572
(lncRNA)
→
has
→
Object:
clinical_prognostic_value
(Clinical Outcomes)
Original: LINC01572#has#oncogenic roles and clinical prognostic value
#19199
middle Confidence
Subject:
p53_gene_alterations
(Gene mutation)
→
are_associated_with
→
Object:
malignant_activity_of_tumor_cells
(Malignant phenotype)
Original: p53 gene alterations#are associated with#malignant activity of tumor cells
#19133
middle Confidence
Subject:
two_dimensional_AgNOR_evaluation
(Molecular analysis technology)
→
serves_as
→
Object:
prognostic_parameter
(Prognostic parameters)
Original: Two-dimensional AgNOR evaluation#may serve as#a prognostic parameter and indicator of cell proliferation
#19097
middle Confidence
Subject:
nucleoli_number
(Nuclear structure)
→
is_used_as
→
Object:
prognostic_tool_for_tumor_proliferation
(Clinical Tools)
Original: Increased number of nucleoli#is used as#prognostic tools to evaluate tumor proliferation levels
#19066
middle Confidence
Subject:
Primary_cutaneous_ALCL
(Tumor subtype)
→
presents_as
→
Object:
localized_skin_tumors
(Tumor phenotype)
Original: Primary cutaneous ALCL#presents as#localized skin tumors with better prognosis
#19064
middle Confidence
Subject:
advanced_stage_tumor
(Tumor type)
→
results_in
→
Object:
early_death_within_3_months
(Early death)
Original: Patients#died within#3 months due to advanced stage chemoresistant tumors
#19030
middle Confidence
Subject:
JHDM1B
(Histone demethylase)
→
is_downregulated_in
→
Object:
aggressive_brain_tumors
(Disease phenotype)
Original: Low levels of JHDM1B expression#are found in#aggressive brain tumors
#18960
middle Confidence
Subject:
downregulation_of_calpain_3_variant
(Protein expression status)
→
contributes_to
→
Object:
melanoma_progression
(Disease progression)
Original: Downregulation of calpain 3 variants#contributes to#melanoma progression
#18940
middle Confidence
Subject:
distinct_nucleoli
(Prominent nucleoli)
→
correlates_with
→
Object:
surgical_outcomes
(Surgical Outcome)
Original: parameters like nuclear irregularity and distinct nucleoli#correlate with#surgical outcomes
#18939
middle Confidence
Subject:
nuclear_irregularity
(Nuclear irregularity)
→
correlates_with
→
Object:
surgical_outcomes
(Surgical Outcome)
Original: parameters like nuclear irregularity and distinct nucleoli#correlate with#surgical outcomes
#18930
middle Confidence
Subject:
AgNOR_quantity
(Molecular markers)
→
is_of_value_in
→
Object:
monitoring_risk_groups
(Clinical risk stratification)
Original: Beta-glucuronidase involvement and increased AgNOR quantity#are of value in#monitoring risk groups of leukemic patients
#18929
middle Confidence
Subject:
beta-glucuronidase
(Hydrolases)
→
is_of_value_in
→
Object:
monitoring_risk_groups
(Clinical risk stratification)
Original: Beta-glucuronidase involvement and increased AgNOR quantity#are of value in#monitoring risk groups of leukemic patients
#18914
middle Confidence
Subject:
AgNORs
(Nucleolar Organizing Region-associated Protein)
→
is_studied_for
→
Object:
prognostic_significance_in_breast_cancer
(Prognostic significance)
Original: c-erbB2 expression and AgNORs#are studied for#prognostic significance in breast cancer
#18913
middle Confidence
Subject:
c-erbB2_expression
(Protein expression)
→
is_studied_for
→
Object:
prognostic_significance_in_breast_cancer
(Prognostic significance)
Original: c-erbB2 expression and AgNORs#are studied for#prognostic significance in breast cancer
#18912
middle Confidence
Subject:
AgNOR_proteins
(Nucleolar Organizing Region-associated Protein)
→
predict
→
Object:
behavior_of_actinic_keratosis
(Sickness Behavior)
Original: AgNOR proteins#predict#behavior of actinic keratosis (AK)
#18906
middle Confidence
Subject:
prognosis_of_tumors
(Prognosis)
→
correlates_with
→
Object:
status_of_margins
(Pathological characteristics)
Original: Prognosis of tumors#appears to be correlated with#staging and status of margins
#18905
middle Confidence
Subject:
prognosis_of_tumors
(Prognosis)
→
correlates_with
→
Object:
staging
(Tumor stage)
Original: Prognosis of tumors#appears to be correlated with#staging and status of margins
#18904
middle Confidence
Subject:
nucleolar_organizer_regions_proliferative_index
(Nucleolar organizer region proliferation index)
→
predictions
→
Object:
hepatocellular_carcinoma_development
(Disease progression)
Original: Nucleolar organizer regions proliferative index#predicts#hepatocellular carcinoma development in hereditary hemochromatosis
#18875
middle Confidence
Subject:
nucleolar_organizer_regions
(Nucleolar organizing region)
→
proposed_as
→
Object:
prognostic_variable
(Prognostic variables)
Original: Nucleolar organizer regions#proposed as#new prognostic variable in breast carcinomas
#18854
middle Confidence
Subject:
histopathological_tumor_front_grade
(Tumor front grade)
→
was_associated_with
→
Object:
tumor-related_death
(Tumor-related death)
Original: AgNOR content of invading tumor cells and histopathological tumor front grade#were associated with#tumor-related death in oral squamous cell carcinomas (OSCCs)
#18853
middle Confidence
Subject:
AgNOR_content_of_invading_tumor_cells
(Nucleolar Organizer Region Content)
→
was_associated_with
→
Object:
tumor-related_death
(Tumor-related death)
Original: AgNOR content of invading tumor cells and histopathological tumor front grade#were associated with#tumor-related death in oral squamous cell carcinomas (OSCCs)
#18850
middle Confidence
Subject:
AgNORs
(Nucleolar organizer region-associated protein)
→
increase_with
→
Object:
malignancy_aggravation
(Tumor malignant progression phenotype)
Original: AgNORs#increase with#aggravating malignancy
#18837
middle Confidence
Subject:
IPT-like_FDC_tumor
(Tumor)
→
is_capable_of
→
Object:
metastasis
(Tumor metastasis)
Original: IPT-like FDC tumor#is capable of#recurrence and metastasis
#18836
middle Confidence
Subject:
IPT-like_FDC_tumor
(Tumor)
→
is_capable_of
→
Object:
recurrence
(Tumor recurrence)
Original: IPT-like FDC tumor#is capable of#recurrence and metastasis
#18821
middle Confidence
Subject:
patients
(patient)
→
died
→
Object:
death
(die)
Original: 8 patients#recurred and#20 died
#18820
middle Confidence
Subject:
patients
(patient)
→
recurred
→
Object:
recurrence
(Disease recurrence)
Original: 8 patients#recurred and#20 died
#18812
middle Confidence
Subject:
Endometrial_carcinoma
(Malignant tumors)
→
is_associated_with
→
Object:
few_or_no_deliveries
(Reproductive phenotype)
Original: Endometrial carcinoma#is associated with#infertility and few or no deliveries
#18811
middle Confidence
Subject:
Endometrial_carcinoma
(Malignant tumors)
→
is_associated_with
→
Object:
infertility
(Reproductive phenotype)
Original: Endometrial carcinoma#is associated with#infertility and few or no deliveries
#18793
middle Confidence
Subject:
NSE
(Enzyme Protein)
→
is_associated_with
→
Object:
enlarged_metastatic_lesions_in_liver
(Liver metastases)
Original: Elevated NSE levels#are associated with#enlarged metastatic lesions in the liver
#18789
middle Confidence
Subject:
Melanotic_schwannomas
(Tumor type)
→
highlight
→
Object:
aggressive_nature
(Disease phenotype)
Original: Melanotic schwannomas#highlight#the aggressive nature of these tumors
#18725
middle Confidence
Subject:
tumors
(Solid Tumors)
→
are_associated_with
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: These tumors#are associated with#poor prognosis and frequent spread to regional lymph nodes
#18689
middle Confidence
Subject:
FLC
(Tumor type)
→
is_associated_with
→
Object:
low_overall_cure_rate
(Disease phenotype)
Original: FLC#is associated with#a low overall cure rate
#18688
middle Confidence
Subject:
FLC
(Tumor type)
→
shows_favorable_prognosis_compared_to
→
Object:
other_hepatic_cancer_subtypes
(Tumor type)
Original: FLC prognosis#is favorable compared to#other hepatic cancer subtypes
#18672
middle Confidence
Subject:
MYC
(Transcription Factors)
→
linearly_related_with
→
Object:
tumor_proliferation
(Cellular Processes)
Original: PCNA/ c-myc p62/ and AgNOR scores#are linearly related#in tumor proliferation assessment
#18671
middle Confidence
Subject:
PCNA
(DNA polymerase accessory factors)
→
linearly_related_with
→
Object:
tumor_proliferation
(Cellular Processes)
Original: PCNA/ c-myc p62/ and AgNOR scores#are linearly related#in tumor proliferation assessment
#18643
middle Confidence
Subject:
Recurrent_tumors
(Recurrent tumor)
→
showed
→
Object:
higher_number_of_nucleolar_organizer_regions
(NOR)
Original: Recurrent tumors#showed#a higher number of nucleolar organizer regions stained by argyrophil method
#18599
middle Confidence
Subject:
AgNOR_proteins
(Nucleolar Organizing Region-associated Protein)
→
have_prognostic_significance_in
→
Object:
gastric_carcinomas
(Malignant tumors)
Original: AgNOR proteins#have#prognostic significance in gastric carcinomas
#18578
middle Confidence
Subject:
diploid_DNA_content
(Diploid DNA content)
→
is_associated_with
→
Object:
favorable_prognosis_in_low_grade_carcinomas
(Low-grade cancer has a good prognosis)
Original: Diploid DNA content#is associated with#favorable prognosis in low-grade carcinomas
#18577
middle Confidence
Subject:
DNA_aneuploidy
(DNA aneuploidy)
→
is_associated_with
→
Object:
high_histologic_grade_tumors
(High-grade tumor)
Original: DNA aneuploidy#is associated with#high histologic grade tumors
#18528
middle Confidence
Subject:
mean_AgNOR_counts
(Chromosome count)
→
is_higher_in
→
Object:
aggressive_basal_cell_carcinoma
(Disease phenotype)
Original: Means of AgNOR counts#is higher in#aggressive basal cell carcinomas compared to nonaggressive ones
#18525
middle Confidence
Subject:
silver_stained_AgNORs
(Silver staining AgNOR)
→
have
→
Object:
prognostic_importance_in_tumors
(Tumor prognostic value)
Original: silver-stained AgNORs#have#prognostic importance in tumors
#18523
middle Confidence
Subject:
PCNA
(Proliferating cell nuclear antigen)
→
is_higher_than
→
Object:
261_per_5_HPFS
(Numerical threshold)
Original: PCNA count#is higher than#261 in five HPFs in dogs with grade 3 mast cell tumors
#18520
middle Confidence
Subject:
AgNOR_counts
(Nucleolar organizer region count)
→
correlates_with
→
Object:
shortened_survival_in_stage_I_and_II_cancer
(Disease phenotype)
Original: Higher AgNOR counts#were associated with#shortened survival in stage I and II disease
#18519
middle Confidence
Subject:
heavy_alcohol_intake
(Environmental exposure factors)
→
affects
→
Object:
long-term_results_in_patients_with_HCV-related_hepatocellular_carcinoma
(Clinical Outcomes)
Original: heavy alcohol intake#affected#long-term results in patients with HCV-related hepatocellular carcinoma
#18501
middle Confidence
Subject:
recurrence
(Disease recurrence)
→
is_linked_to
→
Object:
hTERT_presence
(Telomerase reverse transcriptase expression)
Original: Recurrence#is linked to#hTERT presence
#18428
middle Confidence
Subject:
1-year_follow_up
(Follow-up)
→
showed_no
→
Object:
development_of_metastasis
(Disease phenotype)
Original: At 1-year follow-up#there was no#recurrence or development of metastasis
#18427
middle Confidence
Subject:
1-year_follow_up
(Follow-up)
→
showed_no
→
Object:
recurrence
(Disease phenotype)
Original: At 1-year follow-up#there was no#recurrence or development of metastasis
#18414
middle Confidence
Subject:
Right_ovarian_tumor
(Tumor)
→
metastasized_to
→
Object:
multiple_organs
(Organ systems)
Original: Right ovarian tumor#metastasized to#multiple organs
#18382
middle Confidence
Subject:
patients
(patient)
→
have
→
Object:
high-stage_tumors
(Disease phenotype)
Original: patients#had#high grade/ high stage tumors
#18381
middle Confidence
Subject:
patients
(patient)
→
have
→
Object:
high-grade_tumors
(Disease phenotype)
Original: patients#had#high grade/ high stage tumors
#18377
middle Confidence
Subject:
Findings
(Conclusions)
→
suggest
→
Object:
intra-thymic_metastasis
(Tumor metastasis process)
Original: Findings#suggest#possibility of intra-thymic metastasis rather than multicentric thymoma development
#18325
middle Confidence
Subject:
detached_cribriform_glands
(Organizational Structure)
→
predictions
→
Object:
carcinoma_on_follow-up
(Disease phenotype)
Original: Detached cribriform glands#predicted#carcinoma on follow-up
#18324
middle Confidence
Subject:
bilateral_atypical_cribriform_glands
(Organizational Structure)
→
predictions
→
Object:
carcinoma_on_follow-up
(Disease phenotype)
Original: Bilateral atypical cribriform glands#predicted#carcinoma on follow-up
#18297
middle Confidence
Subject:
Patient
(patient)
→
died_of
→
Object:
CIVNKTC
(Malignant tumors)
Original: Patient#died of#CIVNKTC after CHOP regimen treatment
#18288
middle Confidence
Subject:
Aggressive_behavior
(Disease phenotype)
→
led_to
→
Object:
early_cerebrospinal_fluid_dissemination
(Disease progression)
Original: Aggressive behavior#led to#early cerebrospinal fluid dissemination
#18287
middle Confidence
Subject:
malignant_struma_ovarii
(Tumor tissue)
→
exhibits
→
Object:
aggressive_clinical_course
(Disease phenotype)
Original: Malignant struma ovarii#exhibits#aggressive clinical course with extraovarian spread or recurrence
#18274
middle Confidence
Subject:
EAML
(Tumor type)
→
had_evidence_of
→
Object:
distant metastasis
(Tumor metastasis)
Original: EAML#had evidence of#local recurrence and distant metastasis following open radical nephrectomy
#18273
middle Confidence
Subject:
EAML
(Tumor type)
→
had_evidence_of
→
Object:
local recurrence
(Tumor recurrence)
Original: EAML#had evidence of#local recurrence and distant metastasis following open radical nephrectomy
#18272
middle Confidence
Subject:
myoepithelial carcinoma
(Tumor type)
→
has
→
Object:
metastasis
(Tumor metastasis)
Original: myoepithelial carcinoma#has#increased frequency of local recurrences and metastases compared to its benign counterpart
#18271
middle Confidence
Subject:
myoepithelial carcinoma
(Tumor type)
→
has
→
Object:
local recurrence
(Tumor recurrence)
Original: myoepithelial carcinoma#has#increased frequency of local recurrences and metastases compared to its benign counterpart
#18214
middle Confidence
Subject:
proliferative_index
(Cellular process indicators)
→
correlates_with
→
Object:
clinical_outcome
(Clinical Outcomes)
Original: Proliferative indices#were correlated with#histological features and clinical outcome
#18213
middle Confidence
Subject:
proliferative_index
(Cellular process indicators)
→
correlates_with
→
Object:
histological_features
(Organizational form)
Original: Proliferative indices#were correlated with#histological features and clinical outcome
#18165
middle Confidence
Subject:
tumor_necrosis
(Histopathological features)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: tumor necrosis#is identified as#adverse prognostic factor of RFS
#18164
middle Confidence
Subject:
prominent_nucleoli
(Nuclear morphology)
→
is_identified_as
→
Object:
adverse_prognostic_factor_of_RFS
(Prognostic factors)
Original: prominent nucleoli#is identified as#adverse prognostic factor of RFS
#18151
middle Confidence
Subject:
glioblastoma
(Malignant glioma)
→
metastasizes_to
→
Object:
cervical_lymph_node
(Lymph nodes)
Original: Glioblastoma#metastasized to#a cervical lymph node
#18144
middle Confidence
Subject:
Tubulocystic_renal_cell_carcinoma
(Kidney tumors)
→
has
→
Object:
low_metastatic_tendency
(Transfer tendency)
Original: Tubulocystic renal cell carcinoma#is#a rare kidney neoplasm with low metastatic tendency
#18100
middle Confidence
Subject:
one-third_of_patients_eligible_for_5-year_follow-up
(Patient stratification)
→
were
→
Object:
long-term_symptom-free_survivors
(Long-term symptom-free survivors)
Original: One-third of patients eligible for 5-year follow-up#were#long-term/ symptom-free survivors
#18081
middle Confidence
Subject:
patient
(patient)
→
died_of
→
Object:
cancerous_peritonitis
(Carcinomatous peritonitis)
Original: patient#died of#cancerous peritonitis
#18063
middle Confidence
Subject:
patients
(patient)
→
survived
→
Object:
at_least_9_years_without_metastasis
(Survival)
Original: patients#survived#at least 9 years without metastasis development
#18014
middle Confidence
Subject:
predominantly_flat_high-grade_PIN
(Pathological diagnosis entity)
→
predictions
→
Object:
lower_risk_of_cancer_on_repeat_biopsy
(Disease Risk)
Original: Two findings#predicted#a lower risk of cancer on repeat biopsy: younger age and predominantly flat high-grade PIN
#18013
middle Confidence
Subject:
younger_age
(Patient characteristics)
→
predictions
→
Object:
lower_risk_of_cancer_on_repeat_biopsy
(Disease Risk)
Original: Two findings#predicted#a lower risk of cancer on repeat biopsy: younger age and predominantly flat high-grade PIN
#17923
middle Confidence
Subject:
tumor
(Tumor)
→
developed
→
Object:
lymph_node_metastasis
(Transfer)
Original: tumor#developed#a pushing pattern of stromal invasion and lymph node metastases
#17869
middle Confidence
Subject:
coagulative_necrosis
(Histopathological characteristics)
→
associated_with
→
Object:
poor_DMFRS
(Prognostic indicators)
Original: High grade/ Ki67% and coagulative necrosis#are associated with#poor DMFRS and OS
#17868
middle Confidence
Subject:
tumor_cells_with_high-grade_nuclear_features
(Tumor cell characteristics)
→
observed_in
→
Object:
HG_patients
(Patient characteristics)
Original: HG patients#had#tumor cells with high-grade nuclear features and prominent nucleoli
#17788
middle Confidence
Subject:
aggressive clinical course
(Disease phenotype)
→
results_in
→
Object:
patient death from metastatic disease
(Survival Outcome)
Original: Tumor#pursued#a highly aggressive course/ leading to patient death from metastatic disease
#17787
middle Confidence
Subject:
tumor
(Tumor)
→
leads_to
→
Object:
aggressive clinical course
(Disease phenotype)
Original: Tumor#pursued#a highly aggressive course/ leading to patient death from metastatic disease
#17757
middle Confidence
Subject:
poorly_differentiated_neuroblastoma_subtype
(Tumor molecular subtypes)
→
is_characterized_by
→
Object:
low_mitosis-karyorrhexis_index
(Cell division activity)
Original: Tumors#showed#poorly differentiated neuroblastoma subtype with low mitosis-karyorrhexis index
#17730
middle Confidence
Subject:
malignant_primitive_neuroectodermal_tumor
(Tumor type)
→
associated_with
→
Object:
poor_outcome
(Clinical Outcomes)
Original: Peripheral neuroepithelioma#is#a malignant primitive neuroectodermal tumor with poor outcome
#17721
middle Confidence
Subject:
pancreatic_neuroendocrine_tumors
(Tumor)
→
are_difficult_to_predict
→
Object:
absence_of_metastases_or_invasion
(Disease progression characteristics)
Original: Pancreatic neuroendocrine tumors (NETs)#are difficult to predict#in the absence of metastases or invasion into adjacent organs
#17691
middle Confidence
Subject:
pulmonary_tumor_thrombotic_microangiopathy
(Tumor-related diseases)
→
is_characterized_by
→
Object:
pulmonary_hypertension
(Clinical symptoms)
Original: pulmonary tumor thrombotic microangiopathy (PTTM)#is characterized by#rapid progression of dyspnea and pulmonary hypertension
#17690
middle Confidence
Subject:
pulmonary_tumor_thrombotic_microangiopathy
(Tumor-related diseases)
→
is_characterized_by
→
Object:
rapid_progression_of_dyspnea
(Clinical symptoms)
Original: pulmonary tumor thrombotic microangiopathy (PTTM)#is characterized by#rapid progression of dyspnea and pulmonary hypertension
#17653
middle Confidence
Subject:
Ki-67_score
(Cell cycle protein expression scoring)
→
correlates_with
→
Object:
histopathological_grade_of_malignancy
(Tumor grade)
Original: Ki-67 score#correlated with#histopathological grade of malignancy
#17613
middle Confidence
Subject:
case
(Case)
→
showed
→
Object:
metastasis
(Disease progression)
Original: Seven cases#showed#recurrences and metastases within 2 months to 2 years during follow-up
#17612
middle Confidence
Subject:
case
(Case)
→
showed
→
Object:
recurrence
(Disease progression)
Original: Seven cases#showed#recurrences and metastases within 2 months to 2 years during follow-up
#17541
middle Confidence
Subject:
prognosis
(Prognosis)
→
is_investigated_in
→
Object:
sinonasal_renal_cell_like_adenocarcinoma
(Tumor)
Original: Study#investigated#clinicopathological features/ immunophenotype/ and prognosis of sinonasal renal cell-like adenocarcinoma
#17539
middle Confidence
Subject:
clinicopathological_features
(Clinical characteristics)
→
are_investigated_in
→
Object:
sinonasal_renal_cell_like_adenocarcinoma
(Tumor)
Original: Study#investigated#clinicopathological features/ immunophenotype/ and prognosis of sinonasal renal cell-like adenocarcinoma
#17490
middle Confidence
Subject:
melanotic_schwannomas
(Tumor)
→
exhibit
→
Object:
poor_prognosis
(Disease phenotype)
Original: melanotic schwannomas#exhibit#poor prognosis with recurrences or metastases
#17406
middle Confidence
Subject:
Subset_of_patients_with_well-differentiated_adenocarcinoma_of_the_prostate
(Patient subgroups)
→
have
→
Object:
local_failure_after_radiation_therapy
(Clinical Outcomes)
Original: A subset of patients with well-differentiated adenocarcinoma of the prostate#have#more irregular tumor nuclei and local failure after radiation therapy
#17405
middle Confidence
Subject:
Subset_of_patients_with_well-differentiated_adenocarcinoma_of_the_prostate
(Patient subgroups)
→
have
→
Object:
more_irregular_tumor_nuclei
(Cell morphology)
Original: A subset of patients with well-differentiated adenocarcinoma of the prostate#have#more irregular tumor nuclei and local failure after radiation therapy
#17399
middle Confidence
Subject:
patients
(patient)
→
did_not_have
→
Object:
metastatic_disease
(Disease progression events)
Original: patients#did not have#local recurrence or metastatic disease
#17398
middle Confidence
Subject:
patients
(patient)
→
did_not_have
→
Object:
local_recurrence
(Disease progression events)
Original: patients#did not have#local recurrence or metastatic disease
#17347
middle Confidence
Subject:
prostatic_carcinomas
(Malignant tumors)
→
are_associated_with
→
Object:
perineural_invasion
(Histological phenotype)
Original: prostatic carcinomas#are associated with#perineural invasion
#17346
middle Confidence
Subject:
morphologic_features
(Tissue morphology)
→
have
→
Object:
prognostic_impact_in_neuroblastoma
(Clinical prognostic significance)
Original: morphologic features#have#prognostic impact in neuroblastoma
#17338
middle Confidence
Subject:
FH-deficient_RCC
(Tumor subtype)
→
shows
→
Object:
good_prognosis
(Prognosis)
Original: FH-deficient RCC#might mainly occur in#young women and show a relatively good prognosis
#17334
middle Confidence
Subject:
tubular_adenocarcinoma
(Tumor type)
→
invades
→
Object:
submucosa
(Organizational Structure)
Original: endoscopic submucosal dissection#revealed#tubular adenocarcinoma/ well-differentiated/ with slight submucosal invasion
#17303
middle Confidence
Subject:
malignant_tumor
(Tumor)
→
is_characterized_by
→
Object:
frequent_metastases
(Metastatic phenotype)
Original: Malignant tumor#is characterized by#poor differentiation/ rapid growth/ invasive growth/ no capsule/ and frequent metastases
#17302
middle Confidence
Subject:
malignant_tumor
(Tumor)
→
is_characterized_by
→
Object:
no_capsule
(Organizational Structure)
Original: Malignant tumor#is characterized by#poor differentiation/ rapid growth/ invasive growth/ no capsule/ and frequent metastases
#17301
middle Confidence
Subject:
malignant_tumor
(Tumor)
→
is_characterized_by
→
Object:
invasive_growth
(Cellular Processes)
Original: Malignant tumor#is characterized by#poor differentiation/ rapid growth/ invasive growth/ no capsule/ and frequent metastases
#17300
middle Confidence
Subject:
malignant_tumor
(Tumor)
→
is_characterized_by
→
Object:
rapid_growth
(Cellular Processes)
Original: Malignant tumor#is characterized by#poor differentiation/ rapid growth/ invasive growth/ no capsule/ and frequent metastases
#17299
middle Confidence
Subject:
malignant_tumor
(Tumor)
→
is_characterized_by
→
Object:
poor_differentiation
(Cell differentiation state)
Original: Malignant tumor#is characterized by#poor differentiation/ rapid growth/ invasive growth/ no capsule/ and frequent metastases
#17286
middle Confidence
Subject:
AgNOR_scores
(Molecular markers)
→
increase_with
→
Object:
degrees_of_malignancy
(Malignancy)
Original: AgNOR scores in phyllodes tumours#tended to increase with#degrees of malignancy
#17269
middle Confidence
Subject:
cytologic_phenotype
(Cytological characteristics)
→
can_change_over_time
→
Object:
tumor_related_mortality
(Disease phenotype)
Original: cytologic phenotype#can change#considerably over time/ increasing tumor-related mortality
#17152
middle Confidence
Subject:
bone_metastases
(Disease phenotype)
→
are_associated_with
→
Object:
growth_factors
(Growth Factors)
Original: growth factors#correlate with#bone metastases
#17151
middle Confidence
Subject:
growth_factors
(Growth Factors)
→
correlate_with
→
Object:
bone_metastases
(Disease phenotype)
Original: growth factors#correlate with#bone metastases
#17077
middle Confidence
Subject:
T-helper_cells
(Immune cells)
→
exhibit
→
Object:
aggressive_clinical_course
(Disease phenotype)
Original: T-helper phenotype cells#exhibited#frequent skin involvement and aggressive clinical course
#16958
middle Confidence
Subject:
nucleolar_abnormalities
(Abnormal nuclear structure)
→
are_linked_to
→
Object:
cancer
(Tumor)
Original: Nucleolar abnormalities#are linked to#neurodegenerative diseases and cancer
#16957
middle Confidence
Subject:
nucleolar_abnormalities
(Abnormal nuclear structure)
→
are_linked_to
→
Object:
neurodegenerative_diseases
(Neurological disorders)
Original: Nucleolar abnormalities#are linked to#neurodegenerative diseases and cancer
#16947
middle Confidence
Subject:
CK2α_localization
(Protein subcellular localization)
→
is_associated_with
→
Object:
poor_prognosis_in_invasive_breast_cancer
(Poor prognosis)
Original: CK2α localization#is associated with#a poor prognosis in invasive breast cancer
#16880
middle Confidence
Subject:
CCND1
(Cell cycle proteins)
→
is_related_with
→
Object:
prognosis_of_HCC
(Disease Outcome)
Original: Cytoplasmic cyclin D1 expression#is related to#prognosis of HCC
#16712
middle Confidence
Subject:
quantitative_histopathological_variables
(Histological characteristics)
→
are_prognostic_for
→
Object:
melanoma_patients
(Patient population)
Original: quantitative histopathological variables#were prognostic for#melanoma patients
#16707
middle Confidence
Subject:
nucleolar_function
(Nucleolar function)
→
is_related_with
→
Object:
tumor_mass_growth_rate
(Tumor growth rate)
Original: Relationship between nucleolar size and function#was studied in relation to#tumor mass growth rate
#16706
middle Confidence
Subject:
nucleolar_size
(Nucleolus size)
→
is_related_with
→
Object:
tumor_mass_growth_rate
(Tumor growth rate)
Original: Relationship between nucleolar size and function#was studied in relation to#tumor mass growth rate
#16704
middle Confidence
Subject:
feminizing_adrenal_tumors
(Tumor)
→
are_associated_with
→
Object:
malignancy
(Tumor phenotype)
Original: Feminizing adrenal tumors#are associated with#malignancy
#16649
middle Confidence
Subject:
vimentin_expression
(Protein expression)
→
predictions
→
Object:
clinical_outcome
(Clinical Outcomes)
Original: vimentin expression#predicts#clinical outcome
#16648
middle Confidence
Subject:
prognostic_role
(Prognostic role)
→
was_identified_in
→
Object:
breast_cancer
(Breast cancer)
Original: prognostic role#was identified in#breast cancer
#16609
middle Confidence
Subject:
vimentin_positive_SCC
(Keratin-positive squamous cell carcinoma)
→
develops
→
Object:
metastatic_lesions
(Metastatic lesions)
Original: vimentin-positive SCCs#develop#metastatic lesions
#16601
middle Confidence
Subject:
tumor_mass
(Tumor mass)
→
is_independent_prognostic_parameter_for
→
Object:
chronic_lymphocytic_leukemia
(disease)
Original: AgNORs and tumor mass#are#independent prognostic parameters in chronic lymphocytic leukemia
#16600
middle Confidence
Subject:
AgNORs
(Nucleolar organizer region-associated protein)
→
are_independent_prognostic_parameter_for
→
Object:
chronic_lymphocytic_leukemia
(disease)
Original: AgNORs and tumor mass#are#independent prognostic parameters in chronic lymphocytic leukemia
#16569
middle Confidence
Subject:
AgNORs
(Silver-stained nucleolar organizing region)
→
related_to
→
Object:
tumor_grade
(Tumor grade)
Original: AgNORs#related to#tumor stage/ grade/ and p53 expression in bladder carcinoma
#16568
middle Confidence
Subject:
AgNORs
(Silver-stained nucleolar organizing region)
→
related_to
→
Object:
tumor_stage
(Tumor stage)
Original: AgNORs#related to#tumor stage/ grade/ and p53 expression in bladder carcinoma
#16565
middle Confidence
Subject:
Ki-67
(Cell proliferation markers)
→
associated_with
→
Object:
survival
(Clinical Outcomes)
Original: tumor proliferation markers (AgNOR/ PCNA/ Ki-67)#were associated with#survival
#16564
middle Confidence
Subject:
PCNA
(Proliferating cell nuclear antigen)
→
associated_with
→
Object:
survival
(Clinical Outcomes)
Original: tumor proliferation markers (AgNOR/ PCNA/ Ki-67)#were associated with#survival
#16563
middle Confidence
Subject:
AgNOR
(Nucleolar organizer region-associated)
→
associated_with
→
Object:
survival
(Clinical Outcomes)
Original: tumor proliferation markers (AgNOR/ PCNA/ Ki-67)#were associated with#survival
#16562
middle Confidence
Subject:
AgNOR_count
(Nucleolar organizer region-associated)
→
correlates_with
→
Object:
malignant_change
(Disease phenotype)
Original: number of AgNORs per nucleus#correlates with#malignant change
#16524
middle Confidence
Subject:
AgNOR_count_per_cell
(Nucleolar organizer region-related structure counts)
→
is_higher_in
→
Object:
patients_with_short_survival_in_NHL
(Patient population)
Original: AgNOR count/cell#is higher in#patients with short survival in NHL
#16510
middle Confidence
Subject:
dysplasia_classification_system
(Dysplasia grading system)
→
aims_to_predict
→
Object:
evolution_from_AC_to_LSCC
(Evolution from solar cheilitis to lip squamous cell carcinoma)
Original: Comparison of dysplasia classification systems#aims to predict#evolution from AC to LSCC
#16508
middle Confidence
Subject:
Apaf-1_expression
(Protein expression)
→
correlates_with
→
Object:
histological_grade
(Pathological grading)
Original: High Apaf-1 expression#was correlated with#histological grade/ PCNA expression/ age/ depth of invasion/ and angioinvasion
#16487
middle Confidence
Subject:
tumor
(Tumor)
→
is_characterized_as
→
Object:
very_lethal_neoplasm
(Disease phenotype)
Original: This tumor#is characterized as#a very lethal neoplasm
#16325
middle Confidence
Subject:
prostatic_adenocarcinoma_patient
(patient)
→
had
→
Object:
metastatic_disease
(Tumor metastasis)
Original: Three patients#had#high stage tumor or metastatic disease at diagnosis
#16324
middle Confidence
Subject:
prostatic_adenocarcinoma_patient
(patient)
→
had
→
Object:
high_stage_tumor
(Tumor stage)
Original: Three patients#had#high stage tumor or metastatic disease at diagnosis
#16323
middle Confidence
Subject:
oncocytic_carcinoma_case
(Tumor Cases)
→
died_within
→
Object:
2_years
(Death)
Original: 3 cases#died within#2 years
#16322
middle Confidence
Subject:
oncocytic_carcinoma_case
(Tumor Cases)
→
had
→
Object:
local_recurrence_within_2_years
(Tumor recurrence)
Original: 3 cases#had#local recurrence within 2 years
#16321
middle Confidence
Subject:
oncocytic_carcinoma_case
(Tumor Cases)
→
died_of
→
Object:
distant_metastasis
(Tumor metastasis)
Original: 1 case#had#lymphatic metastasis and died of distant metastasis
#16320
middle Confidence
Subject:
oncocytic_carcinoma_case
(Tumor Cases)
→
had
→
Object:
lymphatic_metastasis
(Tumor metastasis)
Original: 1 case#had#lymphatic metastasis and died of distant metastasis
#16319
middle Confidence
Subject:
oncocytic_carcinoma_case
(Tumor Cases)
→
died_of
→
Object:
regional_recurrence
(Tumor recurrence)
Original: 2 cases#died of#region recurrences
#16242
middle Confidence
Subject:
Death
(Clinical Outcomes)
→
occurred_from
→
Object:
tumor
(Tumor type)
Original: Four deaths#occurred from#the tumor after more than 5 years
#16115
middle Confidence
Subject:
aneuploid_tumors
(Tumor subtype)
→
are_associated_with
→
Object:
poorer_overall_survival
(Clinical Outcomes)
Original: Aneuploid tumors#are associated with#poorer overall survival compared to diploid tumors
#16056
middle Confidence
Subject:
Recurrent_tumors
(Recurrent tumor)
→
associated_with
→
Object:
increase_in_4c_components
(Cell cycle components)
Original: Recurrent tumors#are associated with#reduction in diploid cells and increase in 2c-4c and 4c components
#16055
middle Confidence
Subject:
Recurrent_tumors
(Recurrent tumor)
→
associated_with
→
Object:
increase_in_2c-4c_components
(Cell cycle components)
Original: Recurrent tumors#are associated with#reduction in diploid cells and increase in 2c-4c and 4c components
#16054
middle Confidence
Subject:
Recurrent_tumors
(Recurrent tumor)
→
associated_with
→
Object:
reduction_in_diploid_cells
(Changes in cell composition)
Original: Recurrent tumors#are associated with#reduction in diploid cells and increase in 2c-4c and 4c components
#15932
middle Confidence
Subject:
apoptosis_rate
(Cellular Processes)
→
is_higher_in
→
Object:
neoplastic_cells_of_HD
(Tumor cells)
Original: Rate of apoptosis#is higher in#neoplastic cells of HD than benign reactive lymphocytes
#15732
middle Confidence
Subject:
nuclear_size
(Nuclear morphology)
→
is_used_for
→
Object:
prognostication
(Disease prognosis assessment)
Original: nuclear size#is used for#prognostication in endometrial cancer
#15728
middle Confidence
Subject:
AgNOR_count
(Nucleolar organizer region count)
→
is_higher_than
→
Object:
2.25
(Numerical threshold)
Original: AgNOR counts#are higher than#2.25 in dogs with grade 3 mast cell tumors
#15707
middle Confidence
Subject:
AgNOR_counts
(Nucleolar organizer region count)
→
predictions
→
Object:
lung_cancer_specific_mortality
(Disease phenotype)
Original: AgNOR counts#had significant prognostic value for#patients who died of lung cancer
#15638
middle Confidence
Subject:
Patient_2
(patient)
→
was_in_remission_at
→
Object:
last_follow_up_(26_months)
(Clinical Outcomes)
Original: Patient 2#was in remission at#last follow-up/ 26 months after presentation
#15554
middle Confidence
Subject:
patients
(patient)
→
died_of
→
Object:
disease
(disease)
Original: 17 patients#died of#disease at mean follow-up
#15545
middle Confidence
Subject:
high-grade_transformed_SCs
(Adenoid cystic carcinoma high-grade subtype)
→
develop
→
Object:
distant_metastasis
(Disease progression)
Original: High-grade transformed SCs#developed#locoregional recurrence and distant metastasis
#15544
middle Confidence
Subject:
high-grade_transformed_SCs
(Adenoid cystic carcinoma high-grade subtype)
→
develop
→
Object:
locoregional_recurrence
(Disease progression)
Original: High-grade transformed SCs#developed#locoregional recurrence and distant metastasis
#15543
middle Confidence
Subject:
SCs
(Adenoid cystic carcinoma cell)
→
demonstrate
→
Object:
aggressive_clinical_features
(Disease phenotype)
Original: A small subset of SCs#demonstrates#aggressive clinical features with histologically high-grade transformed morphology
#15309
middle Confidence
Subject:
tumor
(Tumor)
→
progresses_rapidly_after
→
Object:
last_chemotherapy
(Therapeutic interventions)
Original: Tumor#progresses rapidly after#last chemotherapy
#15253
middle Confidence
Subject:
clinical_course
(Disease phenotype)
→
is_characterized_by
→
Object:
death_within_eight_months
(Survival Outcome)
Original: clinical course#was characterized by#relentless progression with extensive subarachnoid spread and death within eight months
#15252
middle Confidence
Subject:
clinical_course
(Disease phenotype)
→
is_characterized_by
→
Object:
extensive_subarachnoid_spread
(Disease progression)
Original: clinical course#was characterized by#relentless progression with extensive subarachnoid spread and death within eight months
#15251
middle Confidence
Subject:
clinical_course
(Disease phenotype)
→
is_characterized_by
→
Object:
relentless_progression
(Disease progression)
Original: clinical course#was characterized by#relentless progression with extensive subarachnoid spread and death within eight months
#15187
middle Confidence
Subject:
Neoplasms
(Tumor)
→
were_characterized_by
→
Object:
highly_aggressive_behavior
(Disease phenotype)
Original: Neoplasms#were characterized by#highly aggressive behavior
#15142
middle Confidence
Subject:
thyroid_tumor
(Tumor type)
→
invaded
→
Object:
esophagus
(organ)
Original: Thyroid tumor#invaded#the esophagus
#15140
middle Confidence
Subject:
unfavorable_evolution
(Disease progression)
→
proves
→
Object:
more_aggressive_evolution_of_primitive_testicular_lymphoma
(Disease phenotype)
Original: Unfavorable evolution#proves#a more aggressive evolution of primitive testicular lymphoma
#15137
middle Confidence
Subject:
metastases
(Metastatic lesions)
→
were_found_in
→
Object:
lymph_nodes
(organize)
Original: Metastases#were found in#lung and lymph nodes at 4 weeks
#15136
middle Confidence
Subject:
metastases
(Metastatic lesions)
→
were_found_in
→
Object:
lung
(organ)
Original: Metastases#were found in#lung and lymph nodes at 4 weeks
#14983
middle Confidence
Subject:
tumor
(Tumor tissue)
→
has_morphology
→
Object:
high_grade (Gleason score 7-10)
(Tumor grade)
Original: Tumors#were#high grade (Gleason score 7-10)
#14955
middle Confidence
Subject:
Abdominal_mass
(Tumor phenotype)
→
does_not_rapidly_recur_after
→
Object:
Resection
(Treatment)
Original: Large abdominal mass#does not rapidly recur after#resection
#14925
middle Confidence
Subject:
Death_from_metastases
(Clinical Outcomes)
→
occurred_in
→
Object:
cases_with_nucleolar_area_4.2_micrometer2_in_primary_tumor
(Tumor morphological characteristics)
Original: Death from metastases#occurred in#cases where nucleolar area was 4.2 microm(2) in the primary tumor
#14872
middle Confidence
Subject:
extracranial_metastasis
(Tumor metastasis characteristics)
→
is_uncommon_in
→
Object:
primary_central_nervous_system_neoplasms
(Tumor type)
Original: extracranial metastasis#is uncommon in#primary central nervous system neoplasms
#14800
middle Confidence
Subject:
patient
(patient)
→
expired_after
→
Object:
penile_amputation_with_lung_metastasis
(Clinical operation and transfer)
Original: Patient#expired after#penile amputation with lung metastasis
#14798
middle Confidence
Subject:
Adenoid_squamous_cell_carcinoma
(Tumor type)
→
exhibits
→
Object:
aggressive_behavior
(Disease phenotype)
Original: Adenoid squamous cell carcinoma#is described as#a poorly differentiated variant of the tumor with aggressive behavior
#14769
middle Confidence
Subject:
PA-DLBCL
(Tumor type)
→
is_associated_with
→
Object:
poor outcomes
(Clinical Outcomes)
Original: PA-DLBCL#is predominant in#elderly male patients with advanced clinical stage and poor outcomes
#14767
middle Confidence
Subject:
patient
(patient)
→
died_from
→
Object:
uncontrolled hypercortisolism
(Disease phenotype)
Original: Patient#died from#metastatic disease and uncontrolled hypercortisolism
#14766
middle Confidence
Subject:
patient
(patient)
→
died_from
→
Object:
metastatic disease
(Disease phenotype)
Original: Patient#died from#metastatic disease and uncontrolled hypercortisolism
#14690
middle Confidence
Subject:
molecular_marker
(Molecular markers)
→
predictions
→
Object:
recidivism
(Tumor recurrence)
Original: Markers in transitional meningiomas#predict#recidivism
#14637
middle Confidence
Subject:
tumor_sample
(Tumor tissue samples)
→
was_from
→
Object:
patients_died_of_metastatic_malignant_melanoma
(Clinical outcomes of patients)
Original: Half of tumors#were from#patients who had died of metastatic malignant melanoma
#14441
middle Confidence
Subject:
tumor
(Tumor)
→
developed
→
Object:
pushing_pattern_of_stromal_invasion
(Tumor invasion characteristics)
Original: tumor#developed#a pushing pattern of stromal invasion and lymph node metastases
#14440
middle Confidence
Subject:
tumor
(Tumor)
→
recurred
→
Object:
multiple_times_over_18_years
(Disease process)
Original: tumor#recurred#>10 times over 18 years
#14281
middle Confidence
Subject:
prominent_nucleoli
(Nuclear morphology)
→
observed_in
→
Object:
tumor_cells
(Tumor cells)
Original: HG patients#had#tumor cells with high-grade nuclear features and prominent nucleoli
#14165
middle Confidence
Subject:
metastases
(Tumor metastasis)
→
results_in
→
Object:
death_after_tumor_resection
(Death)
Original: Three patients#died of#metastases after tumor resection
#14099
middle Confidence
Subject:
small_cell_carcinoma
(Tumor type)
→
metastasized_to
→
Object:
right_inguinal_lymph_node
(Anatomy)
Original: A 51-year-old male#presented with#metastasis of a small cell carcinoma of unknown origin in a right inguinal lymph node
#14045
middle Confidence
Subject:
BLBC
(Molecular subtypes)
→
is_associated_with
→
Object:
high_mitotic_number
(Cellular Processes)
Original: BLBCs#are associated with#high mitotic number/ vesicular chromatin
#14044
middle Confidence
Subject:
BLBC
(Molecular subtypes)
→
is_associated_with
→
Object:
nuclear_pleomorphism
(Cell morphology)
Original: BLBC#is associated with#increased mitosis/ nuclear pleomorphism
#14043
middle Confidence
Subject:
BLBC
(Molecular subtypes)
→
is_associated_with
→
Object:
increased_mitosis
(Cellular Processes)
Original: BLBC#is associated with#increased mitosis/ nuclear pleomorphism
#14023
middle Confidence
Subject:
lesion
(Pathological changes)
→
is_associated_with
→
Object:
invasive_tumor_development
(Tumor development process)
Original: The lesion#is associated with#subsequent development of typical invasive tumors if orchiectomy is not performed
#13975
middle Confidence
Subject:
patient
(patient)
→
died_after
→
Object:
non-relenting_deterioration
(Disease progression)
Original: The patient#died after#a 7-month-period of non-relenting deterioration
#13880
middle Confidence
Subject:
patients
(patient)
→
died_of
→
Object:
the_disease
(disease)
Original: 2 patients#died of#the disease at 13 and 37 months after diagnosis
#13879
middle Confidence
Subject:
affected_patients
(patient)
→
had
→
Object:
metastases
(Transfer)
Original: affected patients#had#metastases at presentation or a few months later
#13732
middle Confidence
Subject:
median_follow-up_of_27_months
(Follow-up time)
→
showed
→
Object:
prognosis
(Clinical Outcomes)
Original: median follow-up of 27 months#showed#moderate disease progression and prognosis
#13731
middle Confidence
Subject:
median_follow-up_of_27_months
(Follow-up time)
→
showed
→
Object:
moderate_disease_progression
(Disease phenotype)
Original: median follow-up of 27 months#showed#moderate disease progression and prognosis
#13604
middle Confidence
Subject:
large_cell_neuroblastoma
(Tumor type)
→
were_classified_as
→
Object:
unfavorable_histology_according_to_INPC
(Histological classification)
Original: all 7 LCNs#were classified as#unfavorable histology according to INPC
#13570
middle Confidence
Subject:
renal_oncocytoma
(Tumor type)
→
differs_in
→
Object:
malignant_potential
(Tumor Biology)
Original: chromophobe renal cell carcinoma and renal oncocytoma#have overlapping#features but differ in malignant potential
#13569
middle Confidence
Subject:
chromophobe_renal_cell_carcinoma
(Tumor type)
→
differs_in
→
Object:
malignant_potential
(Tumor Biology)
Original: chromophobe renal cell carcinoma and renal oncocytoma#have overlapping#features but differ in malignant potential
#13568
middle Confidence
Subject:
cyto-pattern
(Cytological morphological characteristics)
→
correlates_with
→
Object:
clinical_outcome
(Clinical Outcomes)
Original: cyto-patterns#correlated with#histological patterns and outcomes
#13471
middle Confidence
Subject:
PLCIS
(Carcinoma in situ)
→
has_association_with
→
Object:
invasive_lobular_carcinoma
(Invasive lobular carcinoma)
Original: PLCIS#has association with#other high-risk lesions and invasive lobular carcinoma
#13470
middle Confidence
Subject:
PLCIS
(Carcinoma in situ)
→
has_association_with
→
Object:
other_high-risk_lesions
(High-risk lesions)
Original: PLCIS#has association with#other high-risk lesions and invasive lobular carcinoma
#13469
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
correlates_with
→
Object:
brain_invasion
(Brain invasion)
Original: tumor grade#correlates with#morphological parameters like pattern/ mitotic index/ cellularity/ pleomorphism/ nucleoli/ small cell population with high nucleus/cytoplasmic ratio/ necrosis/ and brain invasion
#13468
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
correlates_with
→
Object:
Necrosis
(Necrosis)
Original: tumor grade#correlates with#morphological parameters like pattern/ mitotic index/ cellularity/ pleomorphism/ nucleoli/ small cell population with high nucleus/cytoplasmic ratio/ necrosis/ and brain invasion
#13467
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
correlates_with
→
Object:
small_cell_population_with_high_nucleus_cytoplasmic_ratio
(Small cells with high nuclear-cytoplasmic ratio)
Original: tumor grade#correlates with#morphological parameters like pattern/ mitotic index/ cellularity/ pleomorphism/ nucleoli/ small cell population with high nucleus/cytoplasmic ratio/ necrosis/ and brain invasion
#13466
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
correlates_with
→
Object:
nucleoli
(Nucleolus)
Original: tumor grade#correlates with#morphological parameters like pattern/ mitotic index/ cellularity/ pleomorphism/ nucleoli/ small cell population with high nucleus/cytoplasmic ratio/ necrosis/ and brain invasion
#13465
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
correlates_with
→
Object:
Pleomorphism
(Cellular atypia)
Original: tumor grade#correlates with#morphological parameters like pattern/ mitotic index/ cellularity/ pleomorphism/ nucleoli/ small cell population with high nucleus/cytoplasmic ratio/ necrosis/ and brain invasion
#13464
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
correlates_with
→
Object:
Cellularity
(Cell density)
Original: tumor grade#correlates with#morphological parameters like pattern/ mitotic index/ cellularity/ pleomorphism/ nucleoli/ small cell population with high nucleus/cytoplasmic ratio/ necrosis/ and brain invasion
#13463
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
correlates_with
→
Object:
mitotic_index
(Mitotic index)
Original: tumor grade#correlates with#morphological parameters like pattern/ mitotic index/ cellularity/ pleomorphism/ nucleoli/ small cell population with high nucleus/cytoplasmic ratio/ necrosis/ and brain invasion
#13462
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
correlates_with
→
Object:
pattern
(Histological structure)
Original: tumor grade#correlates with#morphological parameters like pattern/ mitotic index/ cellularity/ pleomorphism/ nucleoli/ small cell population with high nucleus/cytoplasmic ratio/ necrosis/ and brain invasion
#13409
middle Confidence
Subject:
benignity_of_lesions
(Benign lesions)
→
is_supported_by
→
Object:
benign_course_after_limited_excisional_biopsy
(Benign clinical course)
Original: Benignity of lesions in nine patients#is supported by#a benign course over a one- to three-year evaluation period after limited excisional biopsy procedures
#13385
middle Confidence
Subject:
high-grade_transformation
(Disease process)
→
presents_as
→
Object:
undifferentiated_carcinoma
(Disease phenotype)
Original: High-grade transformation in adenoid cystic carcinoma#presented as#poorly differentiated adenocarcinoma or undifferentiated carcinoma
#13384
middle Confidence
Subject:
high-grade_transformation
(Disease process)
→
presents_as
→
Object:
poorly_differentiated_adenocarcinoma
(Disease phenotype)
Original: High-grade transformation in adenoid cystic carcinoma#presented as#poorly differentiated adenocarcinoma or undifferentiated carcinoma
#13380
middle Confidence
Subject:
melanotic_schwannomas
(Tumor)
→
exhibit
→
Object:
metastases
(Disease phenotype)
Original: melanotic schwannomas#exhibit#poor prognosis with recurrences or metastases
#13379
middle Confidence
Subject:
melanotic_schwannomas
(Tumor)
→
exhibit
→
Object:
recurrences
(Disease phenotype)
Original: melanotic schwannomas#exhibit#poor prognosis with recurrences or metastases
#13158
middle Confidence
Subject:
Clear-cell_sarcoma
(Tumor type)
→
shows
→
Object:
widespread_metastasis
(Tumor metastasis)
Original: Clear-cell sarcoma#arises from#the leg with widespread metastasis
#13117
middle Confidence
Subject:
tumor
(Tumor)
→
showed
→
Object:
lymph_node_metastasis
(Transfer)
Original: One tumor#showed#lymph node metastasis
#13115
middle Confidence
Subject:
patients
(patient)
→
developed
→
Object:
metastases
(Transfer)
Original: 9 of 15 patients#developed#metastases
#13107
middle Confidence
Subject:
nuclear_cleavage
(Nuclear morphology)
→
predictions
→
Object:
DNA_ploidy_patterns
(Chromosome ploidy status)
Original: Prominent nucleoli and nuclear cleavage#predict#DNA ploidy patterns
#13106
middle Confidence
Subject:
prominent_nucleoli
(Nuclear morphology)
→
predictions
→
Object:
DNA_ploidy_patterns
(Chromosome ploidy status)
Original: Prominent nucleoli and nuclear cleavage#predict#DNA ploidy patterns
#13008
middle Confidence
Subject:
eccrine_porocarcinoma
(Tumor)
→
metastasizes_to
→
Object:
lymph_nodes
(Lymph nodes)
Original: eccrine porocarcinoma#metastasizes to#lymph nodes
#12796
middle Confidence
Subject:
tumors_with_atypical_features
(Tumor type)
→
behaved
→
Object:
more_aggressively
(Aggressive phenotype)
Original: Tumors with atypical features#behaved#more aggressively
#12655
middle Confidence
Subject:
p120
(protein)
→
is_used_as
→
Object:
prognostic_tumor_marker
(Biomarkers)
Original: p120 protein#is used as#a prognostic tumor marker in breast cancer patients
#12492
middle Confidence
Subject:
AgNORs
(Nucleolus-associated silver chromosome structure)
→
correlates_with
→
Object:
clinical_prognostic_parameters_of_breast_cancer
(Clinical parameters)
Original: AgNORs#were correlated with#clinical prognostic parameters of breast cancer
#12324
middle Confidence
Subject:
BCL2_expression
(Anti-apoptotic protein expression)
→
characterizes
→
Object:
malignant_potential
(Malignant phenotype)
Original: Alteration in p53 and bcl-2 protein expression#characterizes#malignant potential of leukemic cells
#12323
middle Confidence
Subject:
TP53_expression
(Transcription factor expression)
→
characterizes
→
Object:
malignant_potential
(Malignant phenotype)
Original: Alteration in p53 and bcl-2 protein expression#characterizes#malignant potential of leukemic cells
#12081
middle Confidence
Subject:
Anaplastic_large_cell_lymphoma
(Tumor diseases)
→
presents_in
→
Object:
advanced_clinical_stages
(Disease phenotype)
Original: ALCL#presents in#advanced clinical stages with B symptoms
#12051
middle Confidence
Subject:
intraepithelial_neoplasia_measures
(Tumor phenotype indicators)
→
correlate_with
→
Object:
high_cancer_association
(Disease phenotype)
Original: Measures of intraepithelial neoplasia and indicators of cellular proliferation#correlate with#high cancer association and quantifiability
#11989
middle Confidence
Subject:
RNA_polymerase_I_activity
(Enzyme activity)
→
is_related_to
→
Object:
tumor_doubling_time
(Tumor doubling time)
Original: RNA polymerase I activity#is related to#tumor doubling time
#11904
middle Confidence
Subject:
Silver_stained_NOR
(Silver staining)
→
is_studied_for
→
Object:
prognostic_significance
(Prognostic significance)
Original: Silver-stained nucleolar organizer regions (AgNORs)#are studied for#prognostic significance in operable invasive breast cancer
#11903
middle Confidence
Subject:
Silver_stained_AgNOR
(Silver staining AgNOR)
→
is_used_for
→
Object:
prognostic_purpose
(Prognostic Use)
Original: Silver stained argyrophilic nucleolar organizer regions (AgNOR)#are used for#diagnostic and prognostic purposes
#11896
middle Confidence
Subject:
vimentin_positivity
(Protein expression positive)
→
is_related_to
→
Object:
risk_of_relapse
(Risk of recurrence)
Original: positivity of vimentin#is related to#risk of relapse
#11825
middle Confidence
Subject:
necrotic_tumor_percentage
(Necrotic tumor ratio)
→
identifies
→
Object:
group_of_patients_with_good_survival
(Good survival patient group)
Original: s/v ratio and necrotic tumor percentage#identify#a group of patients with good survival
#11824
middle Confidence
Subject:
s_v_ratio
(Tumor parenchyma/stroma ratio)
→
identifies
→
Object:
group_of_patients_with_good_survival
(Good survival patient group)
Original: s/v ratio and necrotic tumor percentage#identify#a group of patients with good survival
#11822
middle Confidence
Subject:
patients_with_metastatic_SCC
(patient)
→
expired_within
→
Object:
1_year
(Survival)
Original: 5 patients with metastatic SCC#expired within#1 year
#11810
middle Confidence
Subject:
tumor_thrombus
(Tumor thrombosis)
→
is_related_with
→
Object:
metastasis
(Transfer)
Original: Tumor necrosis/ mitotic activity/ and tumor thrombus#are related with#tumor recurrence and metastasis
#11809
middle Confidence
Subject:
mitotic_activity
(Mitotic activity)
→
is_related_with
→
Object:
metastasis
(Transfer)
Original: Tumor necrosis/ mitotic activity/ and tumor thrombus#are related with#tumor recurrence and metastasis
#11808
middle Confidence
Subject:
tumor_necrosis
(Cell necrosis)
→
is_related_with
→
Object:
metastasis
(Transfer)
Original: Tumor necrosis/ mitotic activity/ and tumor thrombus#are related with#tumor recurrence and metastasis
#11807
middle Confidence
Subject:
tumor_thrombus
(Tumor thrombosis)
→
is_related_with
→
Object:
tumor_recurrence
(Disease recurrence)
Original: Tumor necrosis/ mitotic activity/ and tumor thrombus#are related with#tumor recurrence and metastasis
#11806
middle Confidence
Subject:
mitotic_activity
(Mitotic activity)
→
is_related_with
→
Object:
tumor_recurrence
(Disease recurrence)
Original: Tumor necrosis/ mitotic activity/ and tumor thrombus#are related with#tumor recurrence and metastasis
#11805
middle Confidence
Subject:
tumor_necrosis
(Cell necrosis)
→
is_related_with
→
Object:
tumor_recurrence
(Disease recurrence)
Original: Tumor necrosis/ mitotic activity/ and tumor thrombus#are related with#tumor recurrence and metastasis
#11790
middle Confidence
Subject:
Nucleolar_organizing_regions
(Nuclear structure markers)
→
could_be_used_as
→
Object:
prognostic_factors_for_bowel_neoplasm
(Prognostic factors)
Original: Nucleolar organizing regions (NOR)#could be used as#prognostic factors for bowel neoplasm
#11742
middle Confidence
Subject:
prognostic_variable
(Prognostic variables)
→
applied_to
→
Object:
breast_carcinomas
(Breast cancer)
Original: Nucleolar organizer regions#proposed as#new prognostic variable in breast carcinomas
#11719
middle Confidence
Subject:
PCNA
(Proliferation-related proteins)
→
evaluates
→
Object:
prognostic_value_for_choroidal_melanoma
(Disease prognostic indicators)
Original: DNA content-ploidy/ AgNORs/ and PCNA#evaluate#prognostic value for choroidal melanoma
#11718
middle Confidence
Subject:
AgNORs
(Nucleolar organizer region-associated protein)
→
evaluates
→
Object:
prognostic_value_for_choroidal_melanoma
(Disease prognostic indicators)
Original: DNA content-ploidy/ AgNORs/ and PCNA#evaluate#prognostic value for choroidal melanoma
#11717
middle Confidence
Subject:
DNA_content-ploidy
(Cytogenetic characteristics)
→
evaluates
→
Object:
prognostic_value_for_choroidal_melanoma
(Disease prognostic indicators)
Original: DNA content-ploidy/ AgNORs/ and PCNA#evaluate#prognostic value for choroidal melanoma
#11675
middle Confidence
Subject:
AgNOR_analysis
(Molecular marker analysis)
→
is_important_for
→
Object:
prognostic_purposes
(Prognostic purpose)
Original: AgNOR analysis#is important for#prognostic purposes in tumor pathology
#11674
middle Confidence
Subject:
proliferative_activity
(Cellular process indicators)
→
has
→
Object:
prognostic_significance
(Prognostic significance)
Original: Proliferative activity#has#prognostic significance in human tumors
#11644
middle Confidence
Subject:
AgNOR_parameters
(Molecular markers)
→
discriminates_between
→
Object:
less_aggressive_MPNSTs
(Tumor type)
Original: Tumor necrosis/ mitotic rate/ and AgNOR parameters#discriminate between#less aggressive and more aggressive MPNSTs
#11621
middle Confidence
Subject:
pineal_parenchymal_cell_tumor
(Tumor)
→
correlates_with
→
Object:
survival
(Clinical Outcomes)
Original: Tumors of pineal parenchymal cells#correlated with#survival in 35 cases
#11613
middle Confidence
Subject:
Tumors
(Tumor tissue)
→
show
→
Object:
high_mitotic_activity
(Cell proliferation activity)
Original: Tumors#are characterized by#sheet-like growth of uniform epithelioid cells
#11546
middle Confidence
Subject:
Abnormal_ER_proteins
(protein)
→
associated_with
→
Object:
elevated_cell_proliferation
(Cellular Processes)
Original: Abnormal ER proteins#are associated with#elevated cell proliferation in breast cancer
#11483
middle Confidence
Subject:
patients
(patient)
→
died_with
→
Object:
metastases_to_distant_organs
(Distant metastasis)
Original: Sixteen patients#died with#metastases to distant organs
#11426
middle Confidence
Subject:
OFMT
(Tumor type)
→
has
→
Object:
low_metastatic_potential
(Disease progression characteristics)
Original: OFMT#has#a high local recurrence rate and low metastatic potential
#11425
middle Confidence
Subject:
OFMT
(Tumor type)
→
has
→
Object:
high_local_recurrence_rate
(Disease progression characteristics)
Original: OFMT#has#a high local recurrence rate and low metastatic potential
#11213
middle Confidence
Subject:
follow-up_studies
(Follow-up study)
→
failed_to_show
→
Object:
development_of_borderline_lesion_in_PBC
(PBC border lesions)
Original: follow-up studies#failed to show#development of HCC or its borderline lesion in PBC cases
#11212
middle Confidence
Subject:
follow-up_studies
(Follow-up study)
→
failed_to_show
→
Object:
development_of_HCC
(Hepatocellular carcinoma)
Original: follow-up studies#failed to show#development of HCC or its borderline lesion in PBC cases
#11043
middle Confidence
Subject:
present_time
(Time conditions)
→
shows_no_evidence_of
→
Object:
metastasis
(Transfer)
Original: At the present time#there has not been#any evidence of metastasis
#10957
middle Confidence
Subject:
tumor_mass
(Tumor tissue)
→
progresses_from
→
Object:
2_cm_to_4_cm_in_two_months
(Tumor volume changes)
Original: tumor mass#progressed from#2 cm to 4 cm in two months
#10819
middle Confidence
Subject:
sarcoma_cases
(Tumor Cases)
→
showed_evidence_of
→
Object:
metastasis
(Disease progression)
Original: three of the five sarcoma cases#showed evidence of#recurrence or metastasis
#10818
middle Confidence
Subject:
sarcoma_cases
(Tumor Cases)
→
showed_evidence_of
→
Object:
recurrence
(Disease progression)
Original: three of the five sarcoma cases#showed evidence of#recurrence or metastasis
#10760
middle Confidence
Subject:
BCL2
(Apoptosis regulatory genes)
→
is_considered_as
→
Object:
prognostic_factor_in_laryngeal_carcinoma
(Clinical parameters)
Original: Apoptosis in situ/ p53/ bcl-2/ and AgNOR counts#are considered#prognostic factors in laryngeal carcinoma
#10759
middle Confidence
Subject:
TP53
(Tumor suppressor genes)
→
is_considered_as
→
Object:
prognostic_factor_in_laryngeal_carcinoma
(Clinical parameters)
Original: Apoptosis in situ/ p53/ bcl-2/ and AgNOR counts#are considered#prognostic factors in laryngeal carcinoma
#10758
middle Confidence
Subject:
apoptosis_in_situ
(Cellular Processes)
→
is_considered_as
→
Object:
prognostic_factor_in_laryngeal_carcinoma
(Clinical parameters)
Original: Apoptosis in situ/ p53/ bcl-2/ and AgNOR counts#are considered#prognostic factors in laryngeal carcinoma
#10597
middle Confidence
Subject:
mean_nuclear_area_over_160_microm2
(Nuclear area)
→
is_associated_with
→
Object:
survival_difference
(Survival differences)
Original: mean nuclear area over 160 microm2#is associated with#differences in survival
#10589
middle Confidence
Subject:
mitotic_rate
(Cell cycle parameters)
→
discriminates_between
→
Object:
less_aggressive_MPNSTs
(Tumor type)
Original: Tumor necrosis/ mitotic rate/ and AgNOR parameters#discriminate between#less aggressive and more aggressive MPNSTs
#10401
middle Confidence
Subject:
metastatic_glioblastoma_multiforme
(Tumor type)
→
is
→
Object:
rare_event
(Rare events)
Original: Metastatic glioblastoma multiforme#is#a rare event in patients with repeated surgery
#10392
middle Confidence
Subject:
melanoma_metastasis
(Tumor metastasis)
→
is
→
Object:
relatively_rare_in_GI_tract
(Disease phenotype)
Original: melanoma metastasis#is#relatively rare in GI tract
#10381
middle Confidence
Subject:
clinical_course
(Clinical course)
→
is
→
Object:
benign
(Benign phenotype)
Original: clinical course#was#benign
#10257
middle Confidence
Subject:
PLGA
(Adenomatous tumor)
→
undergoes
→
Object:
histologic_transformation
(Histopathological changes)
Original: PLGA#undergoes#histologic transformation to higher grade neoplasm after 17 and 26 years
#10216
middle Confidence
Subject:
Spindle_cells
(Cell Type)
→
tend_to_have
→
Object:
less_metastatic_potential
(Transfer capability)
Original: Nodules composed of spindle cells#tend to have#less metastatic potential
#10211
middle Confidence
Subject:
follow-up
(Follow-up results)
→
showed
→
Object:
patients_alive_and_free_of_disease
(Clinical Outcomes)
Original: Follow-up#showed#9 patients alive and free of disease
#9708
middle Confidence
Subject:
AI_group_status
(Grouping variables)
→
shorten
→
Object:
disease-free_survival_time
(Clinical Outcomes)
Original: disease-free survival time#was shorter in#AI(+) group compared to AI(-) group
#9540
middle Confidence
Subject:
lesions
(Lesions)
→
did_not_show
→
Object:
tendency_to_recur
(Relapse tendency)
Original: lesions#did not show#tendency to recur
#9419
middle Confidence
Subject:
tumor_cells
(Tumor cells)
→
infiltrate
→
Object:
muscle_tissue
(Muscle tissue)
Original: tumor cells#infiltrate#peripheral fat and muscle tissues
#9418
middle Confidence
Subject:
tumor_cells
(Tumor cells)
→
infiltrate
→
Object:
peripheral_fat_tissue
(Adipose tissue)
Original: tumor cells#infiltrate#peripheral fat and muscle tissues
#9195
middle Confidence
Subject:
prostate_cancers
(Tumor type)
→
has_Gleason_score
→
Object:
8_to_10
(Gleason Grading)
Original: Gleason scores of cases#were#6 (86%)/ 7 (9%)/ and 8 to 10 (5%)
#9194
middle Confidence
Subject:
prostate_cancers
(Tumor type)
→
has_Gleason_score
→
Object:
7
(Gleason Grading)
Original: Gleason scores of cases#were#6 (86%)/ 7 (9%)/ and 8 to 10 (5%)
#9193
middle Confidence
Subject:
prostate_cancers
(Tumor type)
→
has_Gleason_score
→
Object:
6
(Gleason Grading)
Original: Gleason scores of cases#were#6 (86%)/ 7 (9%)/ and 8 to 10 (5%)
#9063
middle Confidence
Subject:
morphology
(Histological morphology)
→
does_not_correlate_with
→
Object:
outcome_in_malignant_struma_ovarii
(Clinical Outcomes)
Original: Morphology#does not correlate with#outcome in malignant struma ovarii
#8932
middle Confidence
Subject:
patients
(patient)
→
died_within
→
Object:
7-11_months_after_treatment
(Survival)
Original: Four patients#died within#7-11 months after treatment began
#8905
middle Confidence
Subject:
patient
(patient)
→
survived
→
Object:
follow_up_period_of_six_to_72_months
(Survival)
Original: Patients#survived#follow-up period varying from six months to 72 months
#8848
middle Confidence
Subject:
Local_recurrence_interval
(Recurrence interval)
→
was
→
Object:
15.3_months
(Time parameters)
Original: Mean local recurrence interval#was#15.3 months
#8756
middle Confidence
Subject:
malignant_melanoma
(Tumor type)
→
has_predilection_for
→
Object:
metastasis_to_small_bowel
(Metastatic sites)
Original: Malignant melanoma#has an unusual predilection for#metastasis to the small bowel
#8628
middle Confidence
Subject:
histological_findings
(Histological findings)
→
indicate
→
Object:
exposure_to_gastric_serosa
(Tumor invasion)
Original: Histological findings#indicate#advanced stage and exposure to the gastric serosa
#8627
middle Confidence
Subject:
histological_findings
(Histological findings)
→
indicate
→
Object:
advanced_stage
(Disease Stage)
Original: Histological findings#indicate#advanced stage and exposure to the gastric serosa
#8274
middle Confidence
Subject:
lymph_node_metastases
(Transfer)
→
documented_in
→
Object:
urothelial_carcinoma_cases
(Case)
Original: Lymph node metastases#were documented in#3 cases
#7967
middle Confidence
Subject:
HLRCC
(Hereditary tumor syndrome)
→
behaves
→
Object:
aggressively
(Disease phenotype)
Original: Renal cancer in HLRCC patients#generally behaves#aggressively even in a small size
#7966
middle Confidence
Subject:
Renal_cancer
(Kidney cancer)
→
behaves
→
Object:
aggressively
(Disease phenotype)
Original: Renal cancer in HLRCC patients#generally behaves#aggressively even in a small size
#7835
middle Confidence
Subject:
Cutaneous_presentation
(Clinical manifestations)
→
associated_with
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: Cutaneous presentation preceding AML#is associated with#poor prognosis
#7547
middle Confidence
Subject:
disease
(disease)
→
demonstrates
→
Object:
aggressive_course
(Clinical course)
Original: disease#demonstrated#aggressive course with transient improvement of skin lesions after chemotherapy
#7359
middle Confidence
Subject:
low_grade_apocrine_IDC
(Disease subtype)
→
behaves
→
Object:
indolent_manner
(Disease progression characteristics)
Original: low-grade apocrine IDC#behaves#in an indolent manner
#7296
middle Confidence
Subject:
case
(Case)
→
showed
→
Object:
low_proliferative_activity
(Cell proliferation characteristics)
Original: Case#showed#low proliferative activity evaluated by MIB-1
#7200
middle Confidence
Subject:
metastatic_cells
(Tumor cells)
→
associated_with
→
Object:
multiple_metastases
(Metastatic phenotype)
Original: A diagnosis of pheochromocytoma with multiple metastases#was made#based on gross and histologic findings
#7142
middle Confidence
Subject:
patients
(patient)
→
died_at
→
Object:
median_follow_up_time_of_4.8_years
(Follow-up time)
Original: 8 patients#died at#median follow-up time of 4.8 years
#6929
middle Confidence
Subject:
tumor
(Tumor tissue)
→
has
→
Object:
benign_course
(Disease progression)
Original: tumor#is frequently associated with#complex endocrine disorders and usually has a benign course
#6767
middle Confidence
Subject:
GCT-BN
(Tumor type)
→
has
→
Object:
prognosis_similar_to_conventional_granulosa_cell_tumors
(Disease Prognosis)
Original: Granulosa cell tumors with bizarre nuclei (GCT-BN)#have#prognosis similar to conventional granulosa cell tumors
#6763
middle Confidence
Subject:
WDPM
(Tumor type)
→
is_considered_to_have
→
Object:
low_malignancy_potential
(Low malignant potential)
Original: WDPM#is considered to be#benign or to have low malignancy potential
#6762
middle Confidence
Subject:
WDPM
(Tumor type)
→
is_considered_to_be
→
Object:
benign
(benign)
Original: WDPM#is considered to be#benign or to have low malignancy potential
#6545
middle Confidence
Subject:
AgNOR_counts
(Nucleolus-associated silver chromosome structure)
→
is_considered_as
→
Object:
prognostic_factor_in_laryngeal_carcinoma
(Clinical parameters)
Original: Apoptosis in situ/ p53/ bcl-2/ and AgNOR counts#are considered#prognostic factors in laryngeal carcinoma
#6274
middle Confidence
Subject:
BrdU_labelling_index
(Cell proliferation markers)
→
is_not_related_to
→
Object:
xenograft_tumor_mass_doubling_time
(Tumor doubling time)
Original: MIB1/ PCNA/ or BrdU LIs#were not related to#xenograft tumor mass doubling time
#6273
middle Confidence
Subject:
PCNA_labelling_index
(Cell proliferation markers)
→
is_not_related_to
→
Object:
xenograft_tumor_mass_doubling_time
(Tumor doubling time)
Original: MIB1/ PCNA/ or BrdU LIs#were not related to#xenograft tumor mass doubling time
#6272
middle Confidence
Subject:
MIB1_labelling_index
(Cell proliferation markers)
→
is_not_related_to
→
Object:
xenograft_tumor_mass_doubling_time
(Tumor doubling time)
Original: MIB1/ PCNA/ or BrdU LIs#were not related to#xenograft tumor mass doubling time
#5864
middle Confidence
Subject:
tumor_necrosis
(Histopathological characteristics)
→
discriminates_between
→
Object:
less_aggressive_MPNSTs
(Tumor type)
Original: Tumor necrosis/ mitotic rate/ and AgNOR parameters#discriminate between#less aggressive and more aggressive MPNSTs
#5693
middle Confidence
Subject:
metastasis
(Disease progression)
→
was_not_observed_for
→
Object:
2_years
(Time characteristics)
Original: There#has been no evidence of#recurrence or metastasis for 2 years
#5692
middle Confidence
Subject:
recurrence
(Disease progression)
→
was_not_observed_for
→
Object:
2_years
(Time characteristics)
Original: There#has been no evidence of#recurrence or metastasis for 2 years
#5008
middle Confidence
Subject:
Nucleolar_organizer_region_count
(Nuclear structure markers)
→
shows_no_correlation_with
→
Object:
clinical_outcome
(Clinical Outcomes)
Original: Nucleolar organizer region count#shows no correlation with#clinical outcome in high-grade bladder TCC
#4685
middle Confidence
Subject:
irregularity_of_T1-NOR
(Cell morphology)
→
changes_with
→
Object:
cancerous_stage_progression
(Disease progression)
Original: The size and irregularity of T1-NOR#changed with#the progress of cancerous stages
#4684
middle Confidence
Subject:
size_of_T1-NOR
(Cell morphology)
→
changes_with
→
Object:
cancerous_stage_progression
(Disease progression)
Original: The size and irregularity of T1-NOR#changed with#the progress of cancerous stages
#4442
low Confidence
Subject:
two_cases
(patient)
→
showed_no_evidence_of
→
Object:
disease_within_five_years
(Disease remission)
Original: two cases#showed no evidence of#disease within two and five years
#4441
low Confidence
Subject:
two_cases
(patient)
→
showed_no_evidence_of
→
Object:
disease_within_two_years
(Disease remission)
Original: two cases#showed no evidence of#disease within two and five years
#4421
low Confidence
Subject:
patient
(patient)
→
was_free_of
→
Object:
metastasis
(Transfer)
Original: All patients#were#male (median age/ 71 years)/ treated by radical nephrectomy and free of recurrence or metastasis (median follow-up/ 62 months)
#4420
low Confidence
Subject:
patient
(patient)
→
was_free_of
→
Object:
recurrence
(Disease recurrence)
Original: All patients#were#male (median age/ 71 years)/ treated by radical nephrectomy and free of recurrence or metastasis (median follow-up/ 62 months)
#4313
low Confidence
Subject:
gross_appearance
(Tumor phenotype)
→
suggests
→
Object:
malignancy
(Disease phenotype)
Original: Tumor size and gross appearance#suggest#malignancy
#4312
low Confidence
Subject:
tumor_size
(Tumor phenotype)
→
suggests
→
Object:
malignancy
(Disease phenotype)
Original: Tumor size and gross appearance#suggest#malignancy
#4207
low Confidence
Subject:
Segregation_of_neoplasms
(Histological phenotype)
→
allows_further_study_of
→
Object:
metastasis
(Clinical Outcomes)
Original: Segregation of these neoplasms#allows further study of#their biologic potential and possible increased rates of local recurrence and metastasis
#4206
low Confidence
Subject:
Segregation_of_neoplasms
(Histological phenotype)
→
allows_further_study_of
→
Object:
local_recurrence
(Clinical Outcomes)
Original: Segregation of these neoplasms#allows further study of#their biologic potential and possible increased rates of local recurrence and metastasis
#4033
low Confidence
Subject:
tumor_cells
(Tumor cells)
→
suggests
→
Object:
malignant_character
(Malignant features)
Original: These morphological findings#suggested#that the tumor cells had a malignant character
#3842
low Confidence
Subject:
benign_sebaceous_neoplasm
(Tumor Entities)
→
has_potential_for
→
Object:
malignant_transformation
(Tumor progression)
Original: benign sebaceous neoplasms#might have#a high potential for malignant transformation
#3421
low Confidence
Subject:
patient
(patient)
→
is_alive_and_free_of_disease
→
Object:
6_years_after_diagnosis
(Survival Outcome)
Original: Patient#is alive and free of disease#6 years after diagnosis
#3209
low Confidence
Subject:
case
(Case)
→
showed
→
Object:
local_recurrence
(Disease phenotype)
Original: 2 cases#showed#local recurrence after incomplete excision
#3159
low Confidence
Subject:
patient
(patient)
→
is_alive_and_well
→
Object:
over_15_years_from_diagnosis
(Survival)
Original: Two patients#are alive and well#over 15 years from diagnosis
#2658
low Confidence
Subject:
small_size_of_GS
(Tumor characteristics)
→
may_contribute_to
→
Object:
good_prognosis
(Good prognosis)
Original: Good prognosis for GS#may be due to#its small size
#2335
low Confidence
Subject:
tumor
(Tumor)
→
recurred_after
→
Object:
13_months
(Time characteristics)
Original: tumor#recurred after#13 months
#2220
low Confidence
Subject:
Patient
(patient)
→
died_within
→
Object:
1-13_months
(Survival)
Original: 3 patients#died within#1-13 months
#2025
low Confidence
Subject:
low-grade_B-cell_lymphoma
(Tumor)
→
may_rapidly_progress_to
→
Object:
T-cell_lineage_lymphoma
(Tumor)
Original: T-cell lineage lymphoma#should be considered if#low-grade B-cell lymphomas rapidly progress
#1903
low Confidence
Subject:
patient
(patient)
→
died
→
Object:
death_within_4_months
(Death)
Original: Patient#died#four months after initial symptoms
#1650
low Confidence
Subject:
PLGA
(disease)
→
may_undergo
→
Object:
high-grade_transformation
(Disease phenotype)
Original: PLGA#may undergo#high-grade transformation after a protracted clinical course
#1419
low Confidence
Subject:
she
(patient)
→
died_after
→
Object:
4_months_of_initial_diagnosis
(Survival)
Original: She#died after#4 months of initial diagnosis
#1386
low Confidence
Subject:
patient
(patient)
→
died_of
→
Object:
disease
(disease)
Original: Three patients#died of#disease
#1121
low Confidence
Subject:
patient
(patient)
→
died
→
Object:
3_months_later
(Survival time)
Original: The patient#died#3 months later
#599
low Confidence
Subject:
death
(Disease Outcome)
→
occurs_within
→
Object:
10_years_after_treatment_of_malignant_melanoma
(Disease process)
Original: recurrence and death#occur within#10 years after treatment of malignant melanoma
#598
low Confidence
Subject:
recurrence
(Disease Outcome)
→
occurs_within
→
Object:
10_years_after_treatment_of_malignant_melanoma
(Disease process)
Original: recurrence and death#occur within#10 years after treatment of malignant melanoma
#587
low Confidence
Subject:
patients
(patient)
→
died_within
→
Object:
ten_months
(time)
Original: Majority of patients#died within#ten months after malignant tumor cells were recovered from pericardial effusion
#548
low Confidence
Subject:
recurrence
(Disease phenotype)
→
is_experienced_by
→
Object:
patients
(patient)
Original: Two patients#experienced#recurrence
#320
low Confidence
Subject:
One patient
(patient)
→
died
→
Object:
death
(die)
Original: One patient#died#8 months after diagnosis
#122
low Confidence
Subject:
AgNOR_cluster_size_measurement
(Nucleolar organizer zone cluster measurements)
→
is_of
→
Object:
poor_prognostic_value
(Prognostic value)
Original: Ag-NOR cluster size measurement#is of#poor diagnostic and prognostic value for feline mammary carcinomas
#112
low Confidence
Subject:
histomorphometric_parameters
(Histomorphometric parameters)
→
require
→
Object:
additional_studies_for_prognostic_significance
(Further study of prognostic significance)
Original: Histomorphometric parameters#require#additional studies for prognostic significance
#63
low Confidence
Subject:
patients_with_T_cell_Burkitts_like_lymphoma
(Patient population)
→
survive
→
Object:
20_weeks
(Survival)
Original: patients with T-cell Burkitt's-like lymphoma#survive#62 weeks and 20 weeks
#62
low Confidence
Subject:
patients_with_T_cell_Burkitts_like_lymphoma
(Patient population)
→
survive
→
Object:
62_weeks
(Survival)
Original: patients with T-cell Burkitt's-like lymphoma#survive#62 weeks and 20 weeks
#45
low Confidence
Subject:
AgNOR_count
(Nuclear protein index)
→
is_not_predictive_of
→
Object:
survival
(Clinical Outcomes)
Original: age/ histological type/ flow cytometric proliferative index/ and AgNOR counts#were not predictive of#survival
#44
low Confidence
Subject:
flow_cytometric_proliferative_index
(Cell proliferation markers)
→
is_not_predictive_of
→
Object:
survival
(Clinical Outcomes)
Original: age/ histological type/ flow cytometric proliferative index/ and AgNOR counts#were not predictive of#survival
#43
low Confidence
Subject:
histological_type
(Histological type)
→
is_not_predictive_of
→
Object:
survival
(Clinical Outcomes)
Original: age/ histological type/ flow cytometric proliferative index/ and AgNOR counts#were not predictive of#survival
#42
low Confidence
Subject:
age
(Demographic characteristics)
→
is_not_predictive_of
→
Object:
survival
(Clinical Outcomes)
Original: age/ histological type/ flow cytometric proliferative index/ and AgNOR counts#were not predictive of#survival