临床相关性：Prognostic significance
A total of 355 records found
#21959
high Confidence
Subject:
Small-cell_variant_of_RO
(Tumor subtype)
→
is_associated_with
→
Object:
good_prognosis
(Good prognosis)
Original: Small-cell variant of RO#is considered#benign renal neoplasms with good prognosis
#21937
high Confidence
Subject:
HLRCC_associated_renal_cell_carcinomas
(Tumor type)
→
present_as
→
Object:
high_stage_at_presentation
(Disease phenotype)
Original: HLRCC-associated renal cell carcinomas#are#high stage at presentation
#21648
high Confidence
Subject:
risk_signature
(Risk Scoring Model)
→
has
→
Object:
independent_prognostic_significance
(Clinical Outcomes)
Original: Risk signature#has#independent prognostic significance for HGSOC
#21643
high Confidence
Subject:
MYB
(Protein coding genes)
→
fusion_and_expression_correlate_with
→
Object:
predictors_of_outcome
(Clinical prognostic indicators)
Original: MYB fusion and protein expression#were correlated with#predictors of outcome in adenoid cystic carcinoma
#21396
high Confidence
Subject:
TP53_protein_expression
(p53 protein expression)
→
is_promising_marker_for
→
Object:
poor_prognosis
(Poor prognosis)
Original: p53-protein expression#appears as#a promising marker of poor prognosis
#21375
high Confidence
Subject:
extra_capsular_spread
(Tumor microenvironment characteristics)
→
is
→
Object:
prognostic_factor_in_HNSCC
(Clinical Outcomes)
Original: Extra Capsular Spread (ECS)#is a#prognostic factor in HNSCC
#21374
high Confidence
Subject:
nucleolus_organizer_regions
(Molecular markers)
→
is_used_to_predict
→
Object:
survival
(Clinical Outcomes)
Original: Nucleolar organizer regions (AgNOR)#were studied to#predict survival in limited squamous cell carcinoma of the lung
#21371
high Confidence
Subject:
Patients_undergoing_surgery_for_colorectal_cancer
(Patient characteristics)
→
are_studied_for
→
Object:
5-year_survival
(Clinical Outcomes)
Original: Patients undergoing surgery for colorectal cancer#are studied for#5-year survival
#21368
high Confidence
Subject:
Histological_assessment_of_nucleolar_morphology
(Histological evaluation)
→
provides
→
Object:
prognostic_information
(Prognostic information)
Original: Histological assessment of nucleolar morphology#provides#reliable prognostic information
#21328
high Confidence
Subject:
Small-cell_variant_of_RO
(Tumor subtype)
→
is_considered
→
Object:
benign_renal_neoplasm
(Benign renal tumor)
Original: Small-cell variant of RO#is considered#benign renal neoplasms with good prognosis
#21313
high Confidence
Subject:
postoperative_radiation
(Radiation therapy)
→
resulted_in
→
Object:
disease-free_status_for_6_years
(Clinical Outcomes)
Original: Postoperative radiation#was given as#50 Gy/ resulting in disease-free status for 6 years
#21297
high Confidence
Subject:
HLRCC_associated_renal_cell_carcinomas
(Tumor type)
→
associated_with
→
Object:
poor_clinical_outcomes
(Clinical Outcomes)
Original: HLRCC-associated renal cell carcinomas#are#high stage at presentation
#21296
high Confidence
Subject:
HLRCC_associated_renal_cell_carcinomas
(Tumor type)
→
associated_with
→
Object:
aggressive_behavior
(Disease phenotype)
Original: HLRCC-associated renal cell carcinomas#are#high stage at presentation
#21269
high Confidence
Subject:
gleason_score
(Tumor grade)
→
varies_to
→
Object:
gleason_score_of_9
(Disease phenotype)
Original: Gleason score#varied from#4 to 9
#21268
high Confidence
Subject:
gleason_score
(Tumor grade)
→
varies_from
→
Object:
gleason_score_of_4
(Disease phenotype)
Original: Gleason score#varied from#4 to 9
#21145
high Confidence
Subject:
Primary_plasma_cell_leukemia
(disease)
→
is
→
Object:
highly_aggressive_plasma_cell_malignancy
(Disease Type)
Original: Primary plasma cell leukemia#is#a rare and highly aggressive plasma cell malignancy
#20993
high Confidence
Subject:
endometrioid_adenocarcinoma
(Tumor type)
→
exhibits
→
Object:
no_lymph_node_metastasis
(Pathological characteristics)
Original: endometrioid adenocarcinomas#exhibit#superficial invasion of myometrium and no lymph node metastasis
#20757
high Confidence
Subject:
Sebaceous_carcinoma
(Tumor type)
→
metastasizes_to
→
Object:
regional_lymph_nodes
(organize)
Original: Sebaceous carcinoma#metastasizes to#regionallymph nodes
#20756
high Confidence
Subject:
Merkel_cell_carcinoma
(Tumor type)
→
metastasizes_to
→
Object:
pancreas
(organ)
Original: Merkel cell carcinoma (MCC)#metastasized to#pancreas
#20571
high Confidence
Subject:
PTEN
(Protein coding genes)
→
mutation_results_in
→
Object:
cancer_predisposition
(Cancer susceptibility)
Original: Germline PTEN mutations#result in#cancer predisposition/ macrocephaly/ and benign hamartomas
#20538
high Confidence
Subject:
CD2
(Immune receptor proteins)
→
is
→
Object:
most_important_prognostic_gene
(Genome level)
Original: CD2#is#the most important prognostic gene among risk signatures
#20536
high Confidence
Subject:
tumor_immune_microenvironment
(Tissue Microenvironment)
→
performs
→
Object:
prediction_of_clinical_outcomes
(Clinical Outcomes)
Original: Tumor immune microenvironment (TME)#performs#a critical function in the prediction of clinical outcomes and treatment effectiveness
#20490
high Confidence
Subject:
cellular_proliferation
(Cellular Processes)
→
gains_importance_for
→
Object:
cancer_prognosis_prediction
(Clinical Outcomes)
Original: Cellular proliferation information#gains#importance for predicting cancer prognosis
#20312
high Confidence
Subject:
SNORA68_expression
(Small nuclear RNA expression)
→
is_associated_with
→
Object:
shorter_disease-free_survival
(Shortened disease-free survival)
Original: SNORA68 expression#is associated with#shorter disease-free survival
#20263
high Confidence
Subject:
metastatic_tumor
(Tumor type)
→
shows
→
Object:
metastasis
(Tumor progression)
Original: Tumor#presented with#metastasis and hyperchromatic nuclei
#20041
high Confidence
Subject:
Patients
(patient)
→
suffered_from
→
Object:
oral_squamous_cell_carcinoma
(Oral squamous cell carcinoma)
Original: Patients#suffered from#oral squamous cell carcinoma and were treated with surgery and DXT
#19936
middle Confidence
Subject:
LAMP1
(Lysosome-associated membrane proteins)
→
correlates_with
→
Object:
longer_survival_after_tumor_resection
(Clinical Outcomes)
Original: High Lamp-1 mRNA expression#correlates with#longer survival in patients after tumor resection
#19931
middle Confidence
Subject:
SETD2_mutation_in_ccRCC
(Gene mutation)
→
is_associated_with
→
Object:
high_grade_transformation
(Tumor progression)
Original: SETD2-mutated ccRCC#showed#high-grade transformation with enlarged tumor cells/ voluminous clear cytoplasm/ irregular nuclei/ and prominent nucleoli
#19890
middle Confidence
Subject:
RanBP17
(RNA binding proteins)
→
serves_as
→
Object:
prognostic_marker_for_HNSCC_patients
(Biomarkers)
Original: RanBP17#could serve as#a prognostic marker for HNSCC patients
#19866
middle Confidence
Subject:
SNORA18L5
(Small nuclear RNA)
→
is_associated_with
→
Object:
shorter_survival_times_of_patients
(Clinical Outcomes)
Original: SNORA18L5#is associated with#shorter survival times of patients
#19833
middle Confidence
Subject:
cytologic_features
(Cytological characteristics)
→
have
→
Object:
prognostic_significance_in_papillary_thyroid_carcinoma
(Prognostic significance of disease)
Original: cytologic features#have#prognostic significance in papillary thyroid carcinoma
#19768
middle Confidence
Subject:
Ag-NOR_protein_area
(Nucleolar Organizing Region Protein Area)
→
correlates_with
→
Object:
survival
(Survival)
Original: Ag-NOR protein area#was correlated with#clinical/ histological/ prognostic factors/ and survival
#19767
middle Confidence
Subject:
Ag-NOR_protein_area
(Nucleolar Organizing Region Protein Area)
→
correlates_with
→
Object:
prognostic_factors
(Prognostic factors)
Original: Ag-NOR protein area#was correlated with#clinical/ histological/ prognostic factors/ and survival
#19747
middle Confidence
Subject:
P53
(Tumor suppressor proteins)
→
has
→
Object:
prognostic_implications_in_non-Hodgkin's_lymphomas
(Prognostic significance)
Original: PCNA/ AgNORs/ and P53#have#prognostic implications in non-Hodgkin's lymphomas
#19746
middle Confidence
Subject:
AgNORs
(Nucleolar Organizing Region-associated Protein)
→
has
→
Object:
prognostic_implications_in_non-Hodgkin's_lymphomas
(Prognostic significance)
Original: PCNA/ AgNORs/ and P53#have#prognostic implications in non-Hodgkin's lymphomas
#19745
middle Confidence
Subject:
PCNA
(protein)
→
has
→
Object:
prognostic_implications_in_non-Hodgkin's_lymphomas
(Prognostic significance)
Original: PCNA/ AgNORs/ and P53#have#prognostic implications in non-Hodgkin's lymphomas
#19734
middle Confidence
Subject:
coefficient_of_variation_of_nucleolar_nuclear_ratio
(Cell morphology index)
→
correlates_with
→
Object:
death
(Death)
Original: Tumor recurrence or death#correlated with#coefficient of variation of nucleolar/nuclear ratio
#19733
middle Confidence
Subject:
coefficient_of_variation_of_nucleolar_nuclear_ratio
(Cell morphology index)
→
correlates_with
→
Object:
tumor_recurrence
(Tumor recurrence)
Original: Tumor recurrence or death#correlated with#coefficient of variation of nucleolar/nuclear ratio
#19726
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
influences
→
Object:
disease_free_survival
(Survival)
Original: p53 LI/ Ki-67 LI/ AgNOR score/ tumor location/ and grade#influenced#disease-free survival
#19725
middle Confidence
Subject:
tumor_location
(Tumor location)
→
influences
→
Object:
disease_free_survival
(Survival)
Original: p53 LI/ Ki-67 LI/ AgNOR score/ tumor location/ and grade#influenced#disease-free survival
#19724
middle Confidence
Subject:
AgNOR_score
(Nucleus-associated molecules)
→
influences
→
Object:
disease_free_survival
(Survival)
Original: p53 LI/ Ki-67 LI/ AgNOR score/ tumor location/ and grade#influenced#disease-free survival
#19723
middle Confidence
Subject:
Ki-67_LI
(Protein expression index)
→
influences
→
Object:
disease_free_survival
(Survival)
Original: p53 LI/ Ki-67 LI/ AgNOR score/ tumor location/ and grade#influenced#disease-free survival
#19722
middle Confidence
Subject:
p53_LI
(Protein expression index)
→
influences
→
Object:
disease_free_survival
(Survival)
Original: p53 LI/ Ki-67 LI/ AgNOR score/ tumor location/ and grade#influenced#disease-free survival
#19721
middle Confidence
Subject:
high_AgNOR_score
(Nucleus-associated molecules)
→
associated_with
→
Object:
reduced_overall_survival
(Survival)
Original: Older age/ high histological grade/ high PCNA LI/ and high AgNOR score#are associated with#reduced overall survival
#19720
middle Confidence
Subject:
high_PCNA_LI
(Cell proliferation markers)
→
associated_with
→
Object:
reduced_overall_survival
(Survival)
Original: Older age/ high histological grade/ high PCNA LI/ and high AgNOR score#are associated with#reduced overall survival
#19719
middle Confidence
Subject:
high_histological_grade
(Tumor grade)
→
associated_with
→
Object:
reduced_overall_survival
(Survival)
Original: Older age/ high histological grade/ high PCNA LI/ and high AgNOR score#are associated with#reduced overall survival
#19718
middle Confidence
Subject:
Older_age
(Patient characteristics)
→
associated_with
→
Object:
reduced_overall_survival
(Survival)
Original: Older age/ high histological grade/ high PCNA LI/ and high AgNOR score#are associated with#reduced overall survival
#19712
middle Confidence
Subject:
cytokeratin_vimentin_co-expression
(Cytokeratin-vimentin co-expression)
→
correlates_with
→
Object:
proliferative_activity_by_PCNA_expression
(Cell proliferation activity)
Original: cytokeratin-vimentin intermediate-sized filaments co-expression#correlates with#proliferative activity of tumor cells studied by PCNA expression and NOR count
#19710
middle Confidence
Subject:
mean_number_of_AgNORs
(Nucleolar organizer region-associated protein)
→
lower_in
→
Object:
non_recurrent_lesions
(Non-recurrent disease)
Original: Mean number of AgNORs#was significantly higher in#recurrent lesions than in non-recurrent/non-aggressive ones
#19709
middle Confidence
Subject:
mean_number_of_AgNORs
(Nucleolar organizer region-associated protein)
→
higher_in
→
Object:
recurrent_lesions
(Recurrent lesions)
Original: Mean number of AgNORs#was significantly higher in#recurrent lesions than in non-recurrent/non-aggressive ones
#19704
middle Confidence
Subject:
low_Ag-NOR_numbers
(Expression level)
→
suggest
→
Object:
better_prognosis
(Survival Outcome)
Original: Ag-NORs in giant cell glioblastomas#showed#low numbers/ suggesting better prognosis
#19688
middle Confidence
Subject:
AgNOR_count
(Molecular markers)
→
is_a_better_prognostic_indicator_than
→
Object:
mitotic_index
(Cell division index)
Original: AgNOR count#is a better prognostic indicator than#histological tumor grade or mitotic index
#19687
middle Confidence
Subject:
AgNOR_count
(Molecular markers)
→
is_a_better_prognostic_indicator_than
→
Object:
histological_tumor_grade
(Pathological grading)
Original: AgNOR count#is a better prognostic indicator than#histological tumor grade or mitotic index
#19677
middle Confidence
Subject:
hTERT
(Telomerase reverse transcriptase)
→
correlates_strongly_with
→
Object:
recurrences
(Tumor recurrence)
Original: hTERT presence#correlates strongly with#recurrences
#19644
middle Confidence
Subject:
complete_excision
(Surgery)
→
resulted_in
→
Object:
no_metastasis
(Clinical Outcomes)
Original: Complete excision#resulted in#no recurrence or metastasis despite cytologic atypia
#19643
middle Confidence
Subject:
complete_excision
(Surgery)
→
resulted_in
→
Object:
no_recurrence
(Clinical Outcomes)
Original: Complete excision#resulted in#no recurrence or metastasis despite cytologic atypia
#19628
middle Confidence
Subject:
modifications_to_nuclear_cytoplasmic_ratio
(Nuclear characteristics)
→
increase_with
→
Object:
progression_toward_malignancy
(Disease progression)
Original: Modifications to nuclear area/ perimeter/ DNA content/ and nuclear/cytoplasmic ratio#increase with#progression toward malignancy
#19627
middle Confidence
Subject:
modifications_to_DNA_content
(Nuclear characteristics)
→
increase_with
→
Object:
progression_toward_malignancy
(Disease progression)
Original: Modifications to nuclear area/ perimeter/ DNA content/ and nuclear/cytoplasmic ratio#increase with#progression toward malignancy
#19626
middle Confidence
Subject:
modifications_to_nuclear_perimeter
(Nuclear characteristics)
→
increase_with
→
Object:
progression_toward_malignancy
(Disease progression)
Original: Modifications to nuclear area/ perimeter/ DNA content/ and nuclear/cytoplasmic ratio#increase with#progression toward malignancy
#19625
middle Confidence
Subject:
modifications_to_nuclear_area
(Nuclear characteristics)
→
increase_with
→
Object:
progression_toward_malignancy
(Disease progression)
Original: Modifications to nuclear area/ perimeter/ DNA content/ and nuclear/cytoplasmic ratio#increase with#progression toward malignancy
#19624
middle Confidence
Subject:
progression_of_cervical_lesions_toward_malignancy
(Disease progression)
→
is_associated_with
→
Object:
gradual_increase_in_phenotypic_cellular_disarrangements
(Abnormal cell phenotype)
Original: Progression of cervical lesions toward malignancy#is associated with#gradual increase in phenotypic cellular disarrangements
#19593
middle Confidence
Subject:
patients
(patient)
→
died_with
→
Object:
inguinal_lymph_node_metastasis
(Inguinal lymph node metastasis)
Original: Four patients#died with#pulmonary metastasis and inguinal lymph node metastasis
#19592
middle Confidence
Subject:
patients
(patient)
→
died_with
→
Object:
pulmonary_metastasis
(Lung metastasis)
Original: Four patients#died with#pulmonary metastasis and inguinal lymph node metastasis
#19576
middle Confidence
Subject:
patients_with_atypical_spermatogonia
(Patient population)
→
are_at_high_risk_of_developing
→
Object:
malignant_testicular_tumors
(Tumor)
Original: Patients with atypical spermatogonia#are at high risk of developing#malignant testicular tumors
#19543
middle Confidence
Subject:
cyto-nuclear_scores_greater_than_3
(Nuclear scoring)
→
are_associated_with
→
Object:
inferior_survival
(Survival Outcome)
Original: High-grade histo-patterns and cyto-nuclear scores > 3#showed#a trend towards inferior survival
#19542
middle Confidence
Subject:
high-grade_histo-patterns
(Organizational hierarchy)
→
are_associated_with
→
Object:
inferior_survival
(Survival Outcome)
Original: High-grade histo-patterns and cyto-nuclear scores > 3#showed#a trend towards inferior survival
#19541
middle Confidence
Subject:
cytological_nuclear_features
(Nuclear characteristics)
→
correlate_with
→
Object:
survival
(Survival Outcome)
Original: Cytological nuclear features#correlate with#histological grade and survival in lung adenocarcinomas
#19540
middle Confidence
Subject:
cytological_nuclear_features
(Nuclear characteristics)
→
correlate_with
→
Object:
histological_grade
(Disease classification)
Original: Cytological nuclear features#correlate with#histological grade and survival in lung adenocarcinomas
#19505
middle Confidence
Subject:
MIB1_proliferative_index
(Proliferation index)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#19479
middle Confidence
Subject:
Stage_IV_epithelioid_mesothelioma
(Tumor stage)
→
is_associated_with
→
Object:
pleomorphic_malignant_nuclei
(Nuclear morphology)
Original: Stage IV epithelioid mesothelioma#is associated with#pleomorphic malignancy nuclei containing vesicular chromatin and prominent nucleoli
#19476
middle Confidence
Subject:
cellular_pleomorphism
(Cytological characteristics)
→
was_marked_in
→
Object:
poorly_differentiated_synovial_sarcoma
(Disease phenotype)
Original: Cellular pleomorphism#was marked in#poorly differentiated synovial sarcomas
#19459
middle Confidence
Subject:
cases
(Case)
→
diagnosed_as
→
Object:
complete_spontaneous_regression_of_primary_malignant_melanomas
(Disease phenotype)
Original: cases#diagnosed as#complete spontaneous regression of primary malignant melanomas
#19451
middle Confidence
Subject:
malignancy
(Disease status)
→
is_associated_with
→
Object:
perineural_invasion
(Histological characteristics)
Original: malignancy#is associated with#perineural invasion
#19360
middle Confidence
Subject:
heteroploidy_in_melanoma
(Chromosomal abnormalities)
→
is_associated_with
→
Object:
worse_prognosis
(Prognosis)
Original: Heteroploidy in melanoma#is associated with#a worse prognosis
#19301
middle Confidence
Subject:
Askin_tumor
(Tumor type)
→
metastasizes_to
→
Object:
scalp
(Anatomical location)
Original: Askin tumor#metastasizes to#the scalp
#19262
middle Confidence
Subject:
malignant_gastrointestinal_neuroectodermal_tumor
(Tumor diseases)
→
has_distinctive
→
Object:
prognosis
(Prognostic features)
Original: malignant gastrointestinal neuroectodermal tumor#has distinctive#clinical/ radiologic/ histomorphology/ immunophenotype/ molecular genetics and prognosis
#19232
middle Confidence
Subject:
cytologic_features
(Cytological characteristics)
→
were_correlated_with
→
Object:
distant_metastasis
(Tumor metastasis)
Original: Cytologic features#were correlated with#lymph node and distant metastases
#19231
middle Confidence
Subject:
cytologic_features
(Cytological characteristics)
→
were_correlated_with
→
Object:
lymph_node_metastasis
(Tumor metastasis)
Original: Cytologic features#were correlated with#lymph node and distant metastases
#19152
middle Confidence
Subject:
FGF2
(Growth factor protein)
→
correlates_with
→
Object:
Vascularity
(Angiogenic phenotype)
Original: Basic fibroblast growth factor expression levels#correlate with#degree of malignancy and vascularity in human gliomas
#19151
middle Confidence
Subject:
FGF2
(Growth factor protein)
→
correlates_with
→
Object:
degree_of_malignancy
(Disease phenotype)
Original: Basic fibroblast growth factor expression levels#correlate with#degree of malignancy and vascularity in human gliomas
#19082
middle Confidence
Subject:
increased_nucleoli_amount
(Cellular substructure)
→
is_connected_with
→
Object:
shorter_disease_free_survival
(Clinical Outcomes)
Original: increased prevalence and amount of nucleoli#are connected with#shorter cancer-specific and disease-free survival
#19081
middle Confidence
Subject:
increased_nucleoli_prevalence
(Cellular substructure)
→
is_connected_with
→
Object:
shorter_cancer_specific_survival
(Clinical Outcomes)
Original: increased prevalence and amount of nucleoli#are connected with#shorter cancer-specific and disease-free survival
#18973
middle Confidence
Subject:
changes_in_colonic_epithelium
(Organizational Change)
→
precedents
→
Object:
malignant_transformation
(Malignant transformation)
Original: changes in colonic epithelium#precede#malignant transformation
#18935
middle Confidence
Subject:
argyrophilic_nucleolar_organizer_regions
(Molecular markers)
→
correlates_with
→
Object:
prognosis_in_pancreatic_ductal_adenocarcinoma
(Disease phenotype)
Original: Argyrophilic nucleolar organizer regions#correlate with#prognosis in ductal adenocarcinoma of the pancreas
#18909
middle Confidence
Subject:
PI_number
(Proliferation Index)
→
is_valuable_for
→
Object:
prognostic_parameter
(Prognostic parameters)
Original: Numbers of PI#are a valuable#prognostic parameter
#18889
middle Confidence
Subject:
CD44
(Cell adhesion molecules)
→
is_linked_to
→
Object:
cancer_progression
(Tumor progression)
Original: DEC1/ CK1/ PCNA/ and CD44#are linked to#cancer progression
#18888
middle Confidence
Subject:
PCNA
(Proliferation-related proteins)
→
is_linked_to
→
Object:
cancer_progression
(Tumor progression)
Original: DEC1/ CK1/ PCNA/ and CD44#are linked to#cancer progression
#18887
middle Confidence
Subject:
CSNK1
(Protein kinase)
→
is_linked_to
→
Object:
cancer_progression
(Tumor progression)
Original: DEC1/ CK1/ PCNA/ and CD44#are linked to#cancer progression
#18886
middle Confidence
Subject:
1-Dec
(Transcription Factors)
→
is_linked_to
→
Object:
cancer_progression
(Tumor progression)
Original: DEC1/ CK1/ PCNA/ and CD44#are linked to#cancer progression
#18876
middle Confidence
Subject:
AgNORs
(The cell nucleus has silver-stained nucleoli)
→
offer
→
Object:
prognostic_indicator
(Prognostic indicators)
Original: AgNORs#offer#an additional prognostic indicator in testicular tumors
#18842
middle Confidence
Subject:
AgNOR_method
(Detection Methods)
→
is_used_to_determine
→
Object:
prognosis_of_tumors
(Prognostic Assessment)
Original: AgNOR method#is used to determine#cell proliferation and prognosis of various tumors
#18825
middle Confidence
Subject:
fibrolamellar carcinoma
(Tumor type)
→
prognosis_is_correlated_with
→
Object:
tumor resectability
(Surgical resectability of the tumor)
Original: prognosis of fibrolamellar carcinoma#is correlated with#tumor resectability
#18783
middle Confidence
Subject:
chondroblastic_osteosarcoma
(Tumor type)
→
is
→
Object:
uniformly_fatal_if_untreated
(Clinical Outcomes)
Original: Chondroblastic osteosarcoma (COS)#is#a uniformly fatal bone malignancy if untreated
#18735
middle Confidence
Subject:
bladder_cancer_recurrence
(Disease events)
→
must_be_predicted_in
→
Object:
nonmuscle_invasive_bladder_cancer_patients
(Patient characteristics)
Original: bladder cancer recurrence#must be predicted in#nonmuscle invasive bladder cancer patients
#18648
middle Confidence
Subject:
Necrosis
(Histopathological characteristics)
→
evaluated_for
→
Object:
prognosis
(Disease phenotype)
Original: Proliferative activity/ angiogenesis/ and necrosis#were evaluated for#prognosis in peripheral nerve sheath tumors
#18647
middle Confidence
Subject:
angiogenesis
(Cellular Processes)
→
evaluated_for
→
Object:
prognosis
(Disease phenotype)
Original: Proliferative activity/ angiogenesis/ and necrosis#were evaluated for#prognosis in peripheral nerve sheath tumors
#18646
middle Confidence
Subject:
proliferative_activity
(Cellular Processes)
→
evaluated_for
→
Object:
prognosis
(Disease phenotype)
Original: Proliferative activity/ angiogenesis/ and necrosis#were evaluated for#prognosis in peripheral nerve sheath tumors
#18609
middle Confidence
Subject:
AgNOR_score
(Nuclear Organism Markers)
→
correlates_with
→
Object:
overall_survival
(Overall survival)
Original: AgNOR score#correlates with#outcome of the disease/ clinical stage/ and OS
#18607
middle Confidence
Subject:
AgNOR_score
(Nuclear Organism Markers)
→
correlates_with
→
Object:
outcome_of_disease
(Disease Outcome)
Original: AgNOR score#correlates with#outcome of the disease/ clinical stage/ and OS
#18595
middle Confidence
Subject:
TP53_protein_expression
(p53 protein expression)
→
is_related_with
→
Object:
clinical_outcome
(Clinical Outcomes)
Original: Ploidy/ p53-protein immunostaining/ and AgNORs#were related to#clinical outcome and tumor weight
#18593
middle Confidence
Subject:
Ploidy
(Ploid state)
→
is_related_with
→
Object:
clinical_outcome
(Clinical Outcomes)
Original: Ploidy/ p53-protein immunostaining/ and AgNORs#were related to#clinical outcome and tumor weight
#18571
middle Confidence
Subject:
AgNOR
(Molecular markers)
→
correlates_with
→
Object:
prognosis
(Disease phenotype)
Original: Silver-binding argyrophilic nucleolar organizer regions (AgNOR)#correlate with#malignant grading and prognosis
#18565
middle Confidence
Subject:
Nuclear_p53_accumulation
(Protein expression phenotype)
→
correlates_with
→
Object:
DNA_aneuploidy
(Genomic abnormalities)
Original: Nuclear p53 accumulation#was observed in#15 tumors/ 10 of which showed DNA aneuploidy
#18556
middle Confidence
Subject:
T-stage
(Tumor staging index)
→
positively_correlates_with
→
Object:
AgNOR_score
(Molecular pathology indicators)
Original: T-stage#positively correlates with#AgNOR score of the tumor
#18546
middle Confidence
Subject:
proliferative_index
(Proliferation Index)
→
positively_correlates_with
→
Object:
tumor_grade
(Tumor grade)
Original: This index#is positively correlated with#tumor grade
#18544
middle Confidence
Subject:
histological_grade
(Histological grading)
→
correlates_with
→
Object:
AgNORs
(Nucleolar organizer region-associated protein)
Original: Correlation between histological grade and Ki-67 and AgNORs#was observed in#breast lesions
#18543
middle Confidence
Subject:
histological_grade
(Histological grading)
→
correlates_with
→
Object:
KI67
(protein)
Original: Correlation between histological grade and Ki-67 and AgNORs#was observed in#breast lesions
#18522
middle Confidence
Subject:
mast_cell_tumors
(Tumor type)
→
show
→
Object:
lower_survival_time
(Survival)
Original: mast cell tumors#show#lower survival time in dogs with histologic grade 3
#18512
middle Confidence
Subject:
Apoptosis
(Cellular Processes)
→
occurs_more_frequently_in
→
Object:
well-differentiated_carcinomas
(Tumor grade)
Original: Apoptosis#was more frequent in#well-differentiated carcinomas and papillomas
#18510
middle Confidence
Subject:
cytoplasmic_NPM_expression
(Protein expression characteristics)
→
does_not_correlate_with
→
Object:
survival
(Survival)
Original: Cytoplasmic expression of NPM#did not correlate with#clinicopathological parameters or survival
#18461
middle Confidence
Subject:
metastasis
(Tumor metastasis)
→
occurred_in
→
Object:
PGM_cases
(patient)
Original: metastasis#occurred in#69.4% of cases
#18365
middle Confidence
Subject:
case
(Case)
→
shows
→
Object:
relatively_good_prognosis
(Clinical Outcomes)
Original: case#shows#a relatively good prognosis compared to other rhabdoid tumors
#18289
middle Confidence
Subject:
tumor_recurrence
(Tumor recurrence)
→
was_not_detected_during
→
Object:
ten_months_of_follow-up
(Follow-up time)
Original: No recurrence#was detected during#ten months of follow-up
#18285
middle Confidence
Subject:
Clear_cell_adenocarcinoma
(Tumor diseases)
→
shows
→
Object:
Necrosis
(Cell necrosis)
Original: Clear cell adenocarcinomas#showed#marked nuclear pleomorphism/ prominent nucleoli/ clear cytoplasm/ and necrosis
#18240
middle Confidence
Subject:
neoplasms
(Tumor)
→
manifest
→
Object:
high_mitotic_activity
(Cell proliferation activity)
Original: All four neoplasms#manifested#high mitotic activity
#18189
middle Confidence
Subject:
histologic_findings
(Histological characteristics)
→
correlated_with
→
Object:
bad_prognosis_in_malignant_melanomas
(Prognostic phenotype)
Original: histologic findings#correlated with#a bad prognosis in malignant melanomas
#18118
middle Confidence
Subject:
oncocytic_carcinoma_of_salivary_gland
(Tumor diseases)
→
is_studied_for
→
Object:
prognosis
(Prognosis)
Original: Oncocytic carcinoma of salivary gland#is studied for#clinicopathological features/ diagnosis/ treatment/ and prognosis
#18101
middle Confidence
Subject:
rhabdoid_tumors
(Tumor type)
→
tend_to_have
→
Object:
poor_outcome
(Clinical Outcomes)
Original: Rhabdoid tumors and tumors with rhabdoid features#tend to have#a poor outcome
#18094
middle Confidence
Subject:
Necrosis
(Pathological characteristics)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#18093
middle Confidence
Subject:
abnormal_mitoses
(Cytological indicators)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#18092
middle Confidence
Subject:
prominent_nucleoli
(Cytological indicators)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#18091
middle Confidence
Subject:
large_cells
(Cytological indicators)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#18090
middle Confidence
Subject:
mitotic_count
(Cytological indicators)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#18089
middle Confidence
Subject:
coarse_chromatin
(Cytological indicators)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#18088
middle Confidence
Subject:
primitive_growth_pattern
(Tumor phenotype)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#18087
middle Confidence
Subject:
angioinvasion
(Tumor phenotype)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#18086
middle Confidence
Subject:
local_invasion
(Tumor phenotype)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#18085
middle Confidence
Subject:
Size
(Tumor phenotype)
→
correlates_significantly_with
→
Object:
metastases
(Disease phenotype)
Original: Size/ local and angioinvasion/ primitive growth pattern/ coarse chromatin/ mitotic count/ large cells/ prominent nucleoli/ MIB1 proliferative index/ abnormal mitoses/ and necrosis#correlated significantly with#metastases
#17975
middle Confidence
Subject:
Patient
(patient)
→
exhibited
→
Object:
benign_clinical_course
(Clinical Outcomes)
Original: Our patient#exhibited#a relatively benign clinical course
#17918
middle Confidence
Subject:
CD5+_DLBCL
(Disease subtype)
→
was_characterized_by
→
Object:
aggressive_features
(Disease phenotype)
Original: CD5+ DLBCL#was characterized by#aggressive features
#17917
middle Confidence
Subject:
nucleoli_morphology
(Nuclear characteristics)
→
was
→
Object:
prognostically_meaningful
(Prognostic features)
Original: Distinction of LP and IBS by nucleoli morphology#was#prognostically meaningful
#17749
middle Confidence
Subject:
prognostic_factors
(Prognostic factors)
→
include
→
Object:
FNCLCC_grade
(Grading)
Original: Prognosis factors#included#efficiency of initial treatment/ distal location/ necrosis/ and FNCLCC grade
#17748
middle Confidence
Subject:
prognostic_factors
(Prognostic factors)
→
include
→
Object:
Necrosis
(Tissue necrosis)
Original: Prognosis factors#included#efficiency of initial treatment/ distal location/ necrosis/ and FNCLCC grade
#17747
middle Confidence
Subject:
prognostic_factors
(Prognostic factors)
→
include
→
Object:
distal_location
(Tumor location)
Original: Prognosis factors#included#efficiency of initial treatment/ distal location/ necrosis/ and FNCLCC grade
#17746
middle Confidence
Subject:
prognostic_factors
(Prognostic factors)
→
include
→
Object:
efficiency_of_initial_treatment
(Treatment response indicators)
Original: Prognosis factors#included#efficiency of initial treatment/ distal location/ necrosis/ and FNCLCC grade
#17705
middle Confidence
Subject:
Esthesioneuroblastoma
(Tumor)
→
metastasizes_to
→
Object:
cervical_lymph_nodes
(Lymph nodes)
Original: Esthesioneuroblastoma#metastasizes to#cervical lymph nodes
#17617
middle Confidence
Subject:
Heteroploidy
(Chromosomal abnormalities)
→
is_correlated_with
→
Object:
melanoma_thickness>2.25mm
(Tumor thickness)
Original: Heteroploidy#is correlated with#high mitotic activity/ marked nuclear pleomorphism/ large nucleoli/ and melanoma thickness > 2.25 mm
#17616
middle Confidence
Subject:
Heteroploidy
(Chromosomal abnormalities)
→
is_correlated_with
→
Object:
large_nucleoli
(Nucleolar structure)
Original: Heteroploidy#is correlated with#high mitotic activity/ marked nuclear pleomorphism/ large nucleoli/ and melanoma thickness > 2.25 mm
#17615
middle Confidence
Subject:
Heteroploidy
(Chromosomal abnormalities)
→
is_correlated_with
→
Object:
marked_nuclear_pleomorphism
(Nuclear pleomorphism)
Original: Heteroploidy#is correlated with#high mitotic activity/ marked nuclear pleomorphism/ large nucleoli/ and melanoma thickness > 2.25 mm
#17614
middle Confidence
Subject:
Heteroploidy
(Chromosomal abnormalities)
→
is_correlated_with
→
Object:
high_mitotic_activity
(Cell proliferation)
Original: Heteroploidy#is correlated with#high mitotic activity/ marked nuclear pleomorphism/ large nucleoli/ and melanoma thickness > 2.25 mm
#17611
middle Confidence
Subject:
Bone_marrow_cells
(Bone marrow cells)
→
growth_patterns_have
→
Object:
prognostic_significance
(Disease phenotype)
Original: CLL growth patterns in bone marrow#have#prognostic significance
#17572
middle Confidence
Subject:
nuclear_grade
(Pathological characteristics)
→
is_associated_with
→
Object:
time_to_recurrence
(Clinical Outcomes)
Original: nuclear grade#is associated with#time to recurrence in patients with surgical resection
#17458
middle Confidence
Subject:
lacrimal_ductal_adenocarcinomas
(Tumor tissue)
→
show
→
Object:
metastases
(Disease phenotype)
Original: Lacrimal ductal adenocarcinomas#show#recurrence in 5 cases and metastases in 2 patients
#17457
middle Confidence
Subject:
lacrimal_ductal_adenocarcinomas
(Tumor tissue)
→
show
→
Object:
recurrence
(Disease phenotype)
Original: Lacrimal ductal adenocarcinomas#show#recurrence in 5 cases and metastases in 2 patients
#17428
middle Confidence
Subject:
Nuclei
(Nucleus)
→
affect
→
Object:
prognostic_significance
(Prognostic significance)
Original: Nuclear findings#affect#cytological diagnosis and prognostic significance
#17363
middle Confidence
Subject:
Pancreatic_acinar-like_adenocarcinoma
(Tumor)
→
exhibited
→
Object:
lymph_node_invasion
(Tumor invasion characteristics)
Original: Pancreatic acinar-like adenocarcinoma#exhibited#lymphovascular/ perineural/ and lymph node invasions
#17362
middle Confidence
Subject:
Pancreatic_acinar-like_adenocarcinoma
(Tumor)
→
exhibited
→
Object:
perineural_invasion
(Tumor invasion characteristics)
Original: Pancreatic acinar-like adenocarcinoma#exhibited#lymphovascular/ perineural/ and lymph node invasions
#17361
middle Confidence
Subject:
Pancreatic_acinar-like_adenocarcinoma
(Tumor)
→
exhibited
→
Object:
lymphovascular_invasion
(Tumor invasion characteristics)
Original: Pancreatic acinar-like adenocarcinoma#exhibited#lymphovascular/ perineural/ and lymph node invasions
#17343
middle Confidence
Subject:
tumor
(Tumor)
→
recurred_after
→
Object:
intralesional_excision
(Therapeutic interventions)
Original: Three tumors#regrew or recurred after#intralesional excision
#17342
middle Confidence
Subject:
tumor
(Tumor)
→
regrew_after
→
Object:
intralesional_excision
(Therapeutic interventions)
Original: Three tumors#regrew or recurred after#intralesional excision
#17339
middle Confidence
Subject:
Patients with FH-deficient atypical uterine leiomyomas
(patient)
→
were_alive_after
→
Object:
median follow-up 27 years
(Follow-up time)
Original: 19 patients#were alive after#FH-deficient atypical uterine leiomyomas (median follow-up 27 years)
#17285
middle Confidence
Subject:
tumor_grade
(Tumor grade)
→
is_statistically_significant_between
→
Object:
lymph_node_positivity
(Lymph node positive)
Original: parameters#are statistically significant between#tumor grade in squamous cell carcinoma and lymph node positivity
#17262
middle Confidence
Subject:
number_of_cells_with_�?_nucleoli_per_nucleus
(Nuclear morphology)
→
is_higher_in
→
Object:
metastatic_tumors
(Tumor)
Original: Number of cells with three or more nucleoli per nuclear section#is higher in#metastatic tumors than nonmetastatic tumors
#17260
middle Confidence
Subject:
cancer_cells_with_distinct_nucleoli
(Tumor cell morphology)
→
are_characteristics_of
→
Object:
aggressive_melanoma_phenotype
(Disease phenotype)
Original: Cancer cells with distinct nucleoli/ greater size/ and number of nucleoli per cell#are characteristics of#aggressive melanoma phenotype
#17138
middle Confidence
Subject:
CST1
(Caspase inhibitors)
→
influences
→
Object:
metastasis_of_ESCC_cells
(Transfer process)
Original: Gain and loss of CST1#influenced#proliferation and metastasis of ESCC
#16684
middle Confidence
Subject:
AgNORs
(Nucleolar Organizing Region Protein)
→
increasing_values_represent
→
Object:
increased_risk_of_metastases
(Disease Risk)
Original: Increasing values of AgNORs#represent#increased risk of metastases
#16632
middle Confidence
Subject:
FGF2
(Growth Factors)
→
correlates_with
→
Object:
histological_grades_of_malignancy
(Pathological grading)
Original: Basic FGF level#correlates with#histological grades of malignancy
#16624
middle Confidence
Subject:
silver_colloid_staining_technique
(Silver gel staining technique)
→
Assess
→
Object:
proliferative_potential_of_central_neurocytoma
(Central neuroblastoma proliferation potential)
Original: silver colloid staining technique#assesses#proliferative potential of central neurocytoma
#16621
middle Confidence
Subject:
carcinomatous_tissue
(Cancer tissue)
→
shows
→
Object:
higher_AgNOR_content
(AgNOR content)
Original: Carcinomatous tissues#show#higher DNA content/ AgNOR content/ and positive reaction of CEA and ER than normal tissue
#16620
middle Confidence
Subject:
carcinomatous_tissue
(Cancer tissue)
→
shows
→
Object:
higher_DNA_content
(DNA content)
Original: Carcinomatous tissues#show#higher DNA content/ AgNOR content/ and positive reaction of CEA and ER than normal tissue
#16613
middle Confidence
Subject:
ACKD-RCC
(Kidney tumors)
→
studied_for
→
Object:
prognostic_features
(Prognostic features)
Original: ACKD-RCC#is studied for#clinicopathologic/ IHC/ histogenetic/ and prognostic features
#16573
middle Confidence
Subject:
TP53
(Tumor suppressor genes)
→
correlates_with
→
Object:
high_histological_grade
(Pathological grading)
Original: p53#correlates with#large AgNOR nuclear surface ratio and high histological grade
#16572
middle Confidence
Subject:
TP53
(Tumor suppressor genes)
→
correlates_with
→
Object:
large_AgNOR_nuclear_surface_ratio
(Nuclear markers)
Original: p53#correlates with#large AgNOR nuclear surface ratio and high histological grade
#16571
middle Confidence
Subject:
AgNOR_counting
(Molecular detection technology)
→
is_evaluated_for
→
Object:
prognostic_significance
(Clinical Outcomes)
Original: AgNOR counting#is evaluated for#prognostic significance in patients
#16561
middle Confidence
Subject:
AgNOR_number
(Number of silver stains associated with the nucleolar organizer region)
→
correlates_with
→
Object:
tumor_grade
(Tumor grade)
Original: AgNOR number and relative area#correlated with#histological tumor grade
#16540
middle Confidence
Subject:
SNORA68
(Small nuclear RNA)
→
correlates_with
→
Object:
ki-67_level
(Proliferation markers)
Original: SNORA68#exhibited#high expression in TNBC and correlated with tumor size/ ki-67 level/ and TNM stage
#16539
middle Confidence
Subject:
SNORA68
(Small nuclear RNA)
→
correlates_with
→
Object:
tumor_size
(Tumor volume)
Original: SNORA68#exhibited#high expression in TNBC and correlated with tumor size/ ki-67 level/ and TNM stage
#16538
middle Confidence
Subject:
pathomorphological_parameters
(Pathological morphological parameters)
→
influenced
→
Object:
prognosis
(Prognosis)
Original: Pathomorphological parameters#influenced#prognosis in carcinomas of oropharynx or hypopharynx
#16518
middle Confidence
Subject:
nucleolar_surface_area
(Nucleolar surface area)
→
has
→
Object:
prognostic_significance_in_prostate_cancer
(Prognostic significance)
Original: nucleolar surface area#has#prognostic significance in prostate cancer
#16456
middle Confidence
Subject:
Tall cell variant
(Tumor subtype)
→
is_associated_with
→
Object:
distant metastasis
(Distant metastasis)
Original: Tall cell variant (TCV)#is associated with#higher local recurrence and distant metastasis
#16455
middle Confidence
Subject:
Tall cell variant
(Tumor subtype)
→
is_associated_with
→
Object:
Higher local recurrence
(Disease recurrence)
Original: Tall cell variant (TCV)#is associated with#higher local recurrence and distant metastasis
#16349
middle Confidence
Subject:
lymph_node_metastasis
(Disease progression events)
→
occurs_in
→
Object:
tub2_tubular_adenocarcinoma
(Tumor classification)
Original: Lymph node metastasis#occurred in#6.4% of tub 1 and 9.4% of tub 2 cases
#16348
middle Confidence
Subject:
lymph_node_metastasis
(Disease progression events)
→
occurs_in
→
Object:
tub1_tubular_adenocarcinoma
(Tumor classification)
Original: Lymph node metastasis#occurred in#6.4% of tub 1 and 9.4% of tub 2 cases
#16343
middle Confidence
Subject:
pituitary_neoplasm
(Tumor type)
→
associated_with
→
Object:
favorable_prognosis
(Clinical Outcomes)
Original: Pituitary neoplasms#have#a much more favorable prognosis
#16275
middle Confidence
Subject:
Tumor
(Tumor)
→
recurred_locally_in
→
Object:
two_cases_after_excision
(Relapse cases)
Original: Tumor#recurred locally in#two cases after excision
#16081
middle Confidence
Subject:
Gastric_lesions
(Pathological changes)
→
have
→
Object:
elevated_propensity_to_advance_to_gastric_cancer
(Risk of tumor progression)
Original: Gastric lesions#have#an elevated propensity to advance to gastric cancer
#16079
middle Confidence
Subject:
early_metastasis
(Metastatic phenotype)
→
is_associated_with
→
Object:
poor_outcome
(Clinical Outcomes)
Original: large tumor size and early metastasis#were associated with#a poor outcome
#16078
middle Confidence
Subject:
large_tumor_size
(Tumor phenotypic characteristics)
→
is_associated_with
→
Object:
poor_outcome
(Clinical Outcomes)
Original: large tumor size and early metastasis#were associated with#a poor outcome
#16061
middle Confidence
Subject:
mesenchymal_cells
(Stromal cells)
→
evaluated_for
→
Object:
prognostic_importance
(Prognostic indicators)
Original: number of slit-like blood vessels and mesenchymal cells#were evaluated for#prognostic importance
#16060
middle Confidence
Subject:
slit-like_blood_vessels_number
(Vascular structure)
→
evaluated_for
→
Object:
prognostic_importance
(Prognostic indicators)
Original: number of slit-like blood vessels and mesenchymal cells#were evaluated for#prognostic importance
#15918
middle Confidence
Subject:
Progression_in_cervical_lesions
(Disease progression)
→
is_marked_by
→
Object:
Appearance_of_cell_clusters_with_different_phenotypic_characters
(Cell phenotype changes)
Original: Progression in cervical lesions#is marked by#appearance of cell clusters with different phenotypic characters
#15917
middle Confidence
Subject:
Cervical_epithelial_proliferative_disease
(Epithelial proliferative diseases)
→
progresses_toward
→
Object:
Malignancy
(Malignant tumors)
Original: Cervical epithelial proliferative disease#progresses toward#malignancy
#15898
middle Confidence
Subject:
AgNOR_proteins
(Nuclear Organism Markers)
→
correlate_with
→
Object:
prognostic_value
(Prognostic value)
Original: AgNOR proteins#correlate with#nuclear grade and prognostic value in endometrial adenocarcinomas
#15883
middle Confidence
Subject:
higher_AgNOR_counts
(AgNOR count rises)
→
are_observed_in
→
Object:
high_grade_tumors
(High-grade tumors)
Original: Addition of toning step#results in#higher AgNOR counts in high-grade tumors
#15882
middle Confidence
Subject:
AgNORs
(Nucleolar organizer region)
→
serve_as
→
Object:
prognostic_discriminator
(Prognostic indicators)
Original: AgNORs#serve as#a prognostic discriminator of different histological types
#15881
middle Confidence
Subject:
Pleomorphic_adenoma
(Benign tumors)
→
may_recur
→
Object:
tumor_recurrence
(Tumor recurrence)
Original: Pleomorphic adenoma (PA)#is considered#benign tumor which may recur and rarely metastasize
#15866
middle Confidence
Subject:
diploid_status
(Ploid state)
→
is_associated_with
→
Object:
good_clinical_outcome
(Good clinical outcome)
Original: Diploid and near-diploid cases#had#good outcomes
#15864
middle Confidence
Subject:
AgNOR_score
(Nucleolar organizer region-related silver staining fraction)
→
is_related_with
→
Object:
clinical_outcome
(Clinical Outcomes)
Original: Ploidy/ p53-protein immunostaining/ and AgNORs#were related to#clinical outcome and tumor weight
#15823
middle Confidence
Subject:
AgNOR
(Molecular markers)
→
increased_frequency_and_enlargement_correlate_with
→
Object:
poor_prognosis
(Clinical Outcomes)
Original: Increased frequency and enlargement of AgNOR#correlate with#poor prognosis
#15776
middle Confidence
Subject:
MDM2
(Protein coding genes)
→
correlates_with
→
Object:
proliferation_index
(Cell proliferation markers)
Original: p53 and MDM2 expression#correlates with#tumor grade and proliferation indices
#15775
middle Confidence
Subject:
MDM2
(Protein coding genes)
→
correlates_with
→
Object:
tumor_grade
(Tumor grade)
Original: p53 and MDM2 expression#correlates with#tumor grade and proliferation indices
#15774
middle Confidence
Subject:
TP53
(Protein coding genes)
→
correlates_with
→
Object:
proliferation_index
(Cell proliferation markers)
Original: p53 and MDM2 expression#correlates with#tumor grade and proliferation indices
#15773
middle Confidence
Subject:
TP53
(Protein coding genes)
→
correlates_with
→
Object:
tumor_grade
(Tumor grade)
Original: p53 and MDM2 expression#correlates with#tumor grade and proliferation indices
#15759
middle Confidence
Subject:
AgNOR_count
(Nucleolar organizer region-associated protein)
→
indicates
→
Object:
proliferative_activity
(Cell proliferation activity)
Original: The AgNOR count#indicates#a relative progression in the proliferative activity of this tumor
#15758
middle Confidence
Subject:
proliferative_activity_of_MEC
(Proliferation activity)
→
correlates_with
→
Object:
histopathological_grade
(Histological grading)
Original: Proliferative activity of MEC#was correlated with#its histopathological grade using AgNOR count
#15748
middle Confidence
Subject:
studied_parameters
(Parameters)
→
suggest
→
Object:
prognostic_indicators
(Prognostic indicators)
Original: Results#suggest#potential value of studied parameters as prognostic indicators for craniopharyngioma types
#15706
middle Confidence
Subject:
AgNORs
(Nucleolar organizer region-associated protein)
→
correlates_with
→
Object:
proliferative_index
(Cell proliferation index)
Original: AgNORs#correlated with#DNA ploidy and proliferative index
#15705
middle Confidence
Subject:
AgNORs
(Nucleolar organizer region-associated protein)
→
correlates_with
→
Object:
DNA_ploidy
(Genome ploidy)
Original: AgNORs#correlated with#DNA ploidy and proliferative index
#15690
middle Confidence
Subject:
Apoptosis
(Cellular Processes)
→
occurs_more_frequently_in
→
Object:
papillomas
(Tumor classification)
Original: Apoptosis#was more frequent in#well-differentiated carcinomas and papillomas
#15683
middle Confidence
Subject:
AgNOR_counts
(Molecular markers)
→
were_studied_in
→
Object:
colonic_tumors
(Tumor tissue)
Original: AgNOR counts#were studied#in tumors from 95 colonic resections
#15663
middle Confidence
Subject:
Benign_resection
(Surgical resection)
→
progressed_to
→
Object:
malignancy
(Malignant tumors)
Original: Two histologically benign resections#progressed to#malignancy
#15662
middle Confidence
Subject:
Nucleolus_count_in_tumor_cells
(Number of nucleoli)
→
correlates_positively_with
→
Object:
primary_tumor_staging
(Tumor stage)
Original: Increased nucleolus count in tumor cells#correlates positively with#primary tumor staging
#15661
middle Confidence
Subject:
Macronucleoli_presence
(Nucleolar morphology)
→
correlates_positively_with
→
Object:
largest_tumor_basal_diameter
(Tumor size)
Original: Macronucleoli presence#correlates positively with#largest tumor basal diameter
#15537
middle Confidence
Subject:
PLC
(Tumor subtype)
→
was_more_frequently
→
Object:
Ki-67_greater_than_10_percent
(Proliferation markers)
Original: PLC#was more frequently#grade III/ estrogen receptor negative/ and had Ki-67 greater than 10% compared with classic ILC
#15536
middle Confidence
Subject:
PLC
(Tumor subtype)
→
was_more_frequently
→
Object:
estrogen_receptor_negative
(Molecular phenotype)
Original: PLC#was more frequently#grade III/ estrogen receptor negative/ and had Ki-67 greater than 10% compared with classic ILC
#15535
middle Confidence
Subject:
PLC
(Tumor subtype)
→
was_more_frequently
→
Object:
grade_III
(Tumor grade)
Original: PLC#was more frequently#grade III/ estrogen receptor negative/ and had Ki-67 greater than 10% compared with classic ILC
#15353
middle Confidence
Subject:
clinical_or_pathologic_feature
(Clinical or pathological features)
→
does_not_affect
→
Object:
likelihood_of_subsequent_cancer
(Disease phenotype)
Original: No clinical or pathologic feature#affected#the likelihood of subsequent cancer
#14920
middle Confidence
Subject:
Undifferentiated_carcinoma
(Tumor diseases)
→
metastasizes_to
→
Object:
lymph_nodes
(Anatomy)
Original: Undifferentiated carcinoma#metastasizes to#lymph nodes
#14892
middle Confidence
Subject:
intestinal_diffuse_large_B-cell_lymphoma
(Malignant tumors)
→
occurred_in
→
Object:
patient_with_previous_history_of_intestinal_diffuse_large_B-cell_lymphoma
(Patient characteristics)
Original: intestinal diffuse large B-cell lymphoma#occurred in#a patient with a previous history of intestinal diffuse large B-cell lymphoma
#14820
middle Confidence
Subject:
tumor
(Tumor)
→
shows
→
Object:
no_distant_metastasis
(Distant metastasis)
Original: No sign of tumor recurrence or distant metastases#was observed#after 21 months of follow-up
#14819
middle Confidence
Subject:
tumor
(Tumor)
→
shows
→
Object:
no_recurrence
(Relapse)
Original: No sign of tumor recurrence or distant metastases#was observed#after 21 months of follow-up
#14785
middle Confidence
Subject:
Necrosis
(Histological characteristics)
→
correlates_with
→
Object:
meningioma_grade
(Tumor grade)
Original: Loss of architecture/ frequent mitotic figures/ high cellularity/ increased nucleo-cytoplasmic ratio/ prominent nucleolus/ brain invasion/ and necrosis#are correlated with#grade of meningiomas
#14784
middle Confidence
Subject:
brain_invasion
(Histological characteristics)
→
correlates_with
→
Object:
meningioma_grade
(Tumor grade)
Original: Loss of architecture/ frequent mitotic figures/ high cellularity/ increased nucleo-cytoplasmic ratio/ prominent nucleolus/ brain invasion/ and necrosis#are correlated with#grade of meningiomas
#14783
middle Confidence
Subject:
prominent_nucleolus
(Cytological characteristics)
→
correlates_with
→
Object:
meningioma_grade
(Tumor grade)
Original: Loss of architecture/ frequent mitotic figures/ high cellularity/ increased nucleo-cytoplasmic ratio/ prominent nucleolus/ brain invasion/ and necrosis#are correlated with#grade of meningiomas
#14782
middle Confidence
Subject:
increased_nucleo-cytoplasmic_ratio
(Cytological characteristics)
→
correlates_with
→
Object:
meningioma_grade
(Tumor grade)
Original: Loss of architecture/ frequent mitotic figures/ high cellularity/ increased nucleo-cytoplasmic ratio/ prominent nucleolus/ brain invasion/ and necrosis#are correlated with#grade of meningiomas
#14781
middle Confidence
Subject:
high_cellularity
(Histological characteristics)
→
correlates_with
→
Object:
meningioma_grade
(Tumor grade)
Original: Loss of architecture/ frequent mitotic figures/ high cellularity/ increased nucleo-cytoplasmic ratio/ prominent nucleolus/ brain invasion/ and necrosis#are correlated with#grade of meningiomas
#14780
middle Confidence
Subject:
frequent_mitotic_figures
(Histological characteristics)
→
correlates_with
→
Object:
meningioma_grade
(Tumor grade)
Original: Loss of architecture/ frequent mitotic figures/ high cellularity/ increased nucleo-cytoplasmic ratio/ prominent nucleolus/ brain invasion/ and necrosis#are correlated with#grade of meningiomas
#14779
middle Confidence
Subject:
loss_of_architecture
(Histological characteristics)
→
correlates_with
→
Object:
meningioma_grade
(Tumor grade)
Original: Loss of architecture/ frequent mitotic figures/ high cellularity/ increased nucleo-cytoplasmic ratio/ prominent nucleolus/ brain invasion/ and necrosis#are correlated with#grade of meningiomas
#14411
middle Confidence
Subject:
tumor_infiltration_depth
(Depth of tumor invasion)
→
associated_with
→
Object:
Immunoblast_cells
(Immune cells)
Original: tumor infiltration depth#associated with#local lymph follicles and immunoblast cells in pT2 and G2 groups
#14410
middle Confidence
Subject:
tumor_infiltration_depth
(Depth of tumor invasion)
→
associated_with
→
Object:
local_lymph_follicles
(Immune structure)
Original: tumor infiltration depth#associated with#local lymph follicles and immunoblast cells in pT2 and G2 groups
#14362
middle Confidence
Subject:
patient
(patient)
→
develops
→
Object:
central_nervous_system_symptoms
(Neurological symptoms)
Original: patient#developed#multiple lesions of the extremities and central nervous system symptoms
#14361
middle Confidence
Subject:
patient
(patient)
→
develops
→
Object:
multiple_lesions_of_extremities
(Disease phenotype)
Original: patient#developed#multiple lesions of the extremities and central nervous system symptoms
#14350
middle Confidence
Subject:
patient
(patient)
→
had_history_of
→
Object:
ALL
(disease)
Original: The patient#had a history of#ALL in remission for 2 years after chemotherapy
#13778
middle Confidence
Subject:
These_cases
(Tumor Cases)
→
are_considered
→
Object:
benign_without_recurrence
(Clinical Outcomes)
Original: These cases#are considered#benign without recurrence
#13577
middle Confidence
Subject:
Tumor_cells
(Tumor cells)
→
contains
→
Object:
focal_necrosis
(Focal necrosis)
Original: Tumor cells#display#moderate to marked nuclear pleomorphism with prominent nucleoli/ eosinophilic to vacuolated cytoplasm/ rhabdoid morphology/ interspersed mitotic figures/ focal necrosis/ and inflammatory cells
#13228
middle Confidence
Subject:
1_patient
(patient)
→
developed
→
Object:
metastasis_to_renal_hilar_lymph_nodes
(Transfer Event)
Original: 1 patient#developed#metastasis to the renal hilar lymph nodes
#13227
middle Confidence
Subject:
5_patients
(Patient population)
→
had
→
Object:
no_evidence_of_disease_after_follow-up
(Clinical Outcomes)
Original: 5 patients#had#no evidence of disease after follow-up
#13187
middle Confidence
Subject:
LCNEC
(Tumor type)
→
has_prognosis_between
→
Object:
SCLC
(Tumor type)
Original: Prognosis of LCNEC#appears to be#intermediate between AC and SCLC
#13186
middle Confidence
Subject:
LCNEC
(Tumor type)
→
has_prognosis_between
→
Object:
AC
(Tumor type)
Original: Prognosis of LCNEC#appears to be#intermediate between AC and SCLC
#13072
middle Confidence
Subject:
large_cell_NECs
(Tumor cell type)
→
have
→
Object:
larger_polygonal_cells
(Cell morphology)
Original: large cell NECs#have#higher mitotic count and larger polygonal cells
#13071
middle Confidence
Subject:
large_cell_NECs
(Tumor cell type)
→
have
→
Object:
higher_mitotic_count
(Cell proliferation characteristics)
Original: large cell NECs#have#higher mitotic count and larger polygonal cells
#13066
middle Confidence
Subject:
Histologic grade
(Histological grading)
→
was_compared_between
→
Object:
larger carcinoma size
(Tumor volume)
Original: Histologic grade/ tumor size/ pathologic stage/ and margin status#were compared#between minimal and larger carcinoma sizes in needle biopsy specimens
#13065
middle Confidence
Subject:
Histologic grade
(Histological grading)
→
was_compared_between
→
Object:
minimal carcinoma size
(Tumor volume)
Original: Histologic grade/ tumor size/ pathologic stage/ and margin status#were compared#between minimal and larger carcinoma sizes in needle biopsy specimens
#13037
middle Confidence
Subject:
Histologic_parameter
(Pathological parameters)
→
includes
→
Object:
prominent_nucleoli
(Cell morphology)
Original: Histologic parameters#included#capsular invasion/ vascular invasion/ cytoplasmic eosinophilia/ and prominent nucleoli
#13036
middle Confidence
Subject:
Histologic_parameter
(Pathological parameters)
→
includes
→
Object:
cytoplasmic_eosinophilia
(Cell morphology)
Original: Histologic parameters#included#capsular invasion/ vascular invasion/ cytoplasmic eosinophilia/ and prominent nucleoli
#13035
middle Confidence
Subject:
Histologic_parameter
(Pathological parameters)
→
includes
→
Object:
vascular_invasion
(Histological characteristics)
Original: Histologic parameters#included#capsular invasion/ vascular invasion/ cytoplasmic eosinophilia/ and prominent nucleoli
#13034
middle Confidence
Subject:
Histologic_parameter
(Pathological parameters)
→
includes
→
Object:
capsular_invasion
(Histological characteristics)
Original: Histologic parameters#included#capsular invasion/ vascular invasion/ cytoplasmic eosinophilia/ and prominent nucleoli
#12750
middle Confidence
Subject:
number_of_cells_with_�?_nucleoli_per_nucleus
(Nuclear morphology)
→
is_lower_in
→
Object:
nonmetastatic_tumors
(Tumor)
Original: Number of cells with three or more nucleoli per nuclear section#is higher in#metastatic tumors than nonmetastatic tumors
#12741
middle Confidence
Subject:
cancer_cells_with_higher_nucleoli_number
(Tumor cell morphology)
→
are_characteristics_of
→
Object:
aggressive_melanoma_phenotype
(Disease phenotype)
Original: Cancer cells with distinct nucleoli/ greater size/ and number of nucleoli per cell#are characteristics of#aggressive melanoma phenotype
#12740
middle Confidence
Subject:
cancer_cells_with_greater_size
(Tumor cell morphology)
→
are_characteristics_of
→
Object:
aggressive_melanoma_phenotype
(Disease phenotype)
Original: Cancer cells with distinct nucleoli/ greater size/ and number of nucleoli per cell#are characteristics of#aggressive melanoma phenotype
#12739
middle Confidence
Subject:
melanoma_cells_with_distinct_nucleoli
(Tumor cell morphology)
→
is_associated_with
→
Object:
lack_of_immunologic_response
(Immune response)
Original: Lack of immunologic response#was associated with#high prevalence of melanoma cells with distinct nucleoli
#12738
middle Confidence
Subject:
immunologic_response
(Immune response)
→
is_associated_with
→
Object:
melanoma_cells_with_distinct_nucleoli
(Tumor cell morphology)
Original: Lack of immunologic response#was associated with#high prevalence of melanoma cells with distinct nucleoli
#12527
middle Confidence
Subject:
RFS_10_year
(Survival rate)
→
reported_as
→
Object:
78_percent
(Survival rate)
Original: 5- and 10-year RFS rates#were reported as#94% and 78% respectively
#12526
middle Confidence
Subject:
RFS_5_year
(Survival rate)
→
reported_as
→
Object:
94_percent
(Survival rate)
Original: 5- and 10-year RFS rates#were reported as#94% and 78% respectively
#12503
middle Confidence
Subject:
nucleolar_organizer_regions
(Nuclear structure)
→
serves_as
→
Object:
prognostic_indicator
(Clinical prognostic indicators)
Original: Nucleolar organizer regions#serve as#a prognostic indicator in epithelial cancers of the ovary
#12169
middle Confidence
Subject:
NCL-1/TRIM2/Brat
(Tumor suppressor proteins)
→
extends
→
Object:
lifespan
(Physiological life span)
Original: NCL-1/TRIM2/Brat tumor suppressor#extends#lifespan and limits nucleolar size
#11969
middle Confidence
Subject:
EMP3
(Membrane Protein)
→
acts_as
→
Object:
tumor_suppressing_factor
(Tumor suppressors)
Original: EMP3#acts as#a tumor-promoting or suppressing factor in malignant tumors
#11968
middle Confidence
Subject:
EMP3
(Membrane Protein)
→
acts_as
→
Object:
tumor_promoting_factor
(Tumor promoting factors)
Original: EMP3#acts as#a tumor-promoting or suppressing factor in malignant tumors
#11837
middle Confidence
Subject:
AgNOR_counts
(Nucleolar Organizing Region Protein Count)
→
are_studied_for
→
Object:
relation_to_prognosis
(Prognostic relevance)
Original: AgNOR counts#are studied for#relation to prognosis in adenoid cystic carcinoma
#11836
middle Confidence
Subject:
AgNORs
(Nucleolar Organizing Region-associated Protein)
→
are_evaluated_for
→
Object:
prognostic_considerations
(Prognostic Assessment)
Original: AgNORs#are evaluated for#prognostic considerations in supratentorial gliomas
#11794
middle Confidence
Subject:
Atrophic_cancer
(Tumor type)
→
is_associated_with
→
Object:
high-grade_prostatic_intraepithelial_neoplasia
(Pathological conditions)
Original: Atrophic cancer#is associated with#high-grade prostatic intraepithelial neoplasia
#11751
middle Confidence
Subject:
AgNORs
(Nucleolar organizer region)
→
serve_as
→
Object:
prognostic_clues
(Prognostic Tips)
Original: AgNORs#serve as#diagnostic and prognostic clues in tumors
#11736
middle Confidence
Subject:
AgNOR_relative_area
(Relative area of nucleolar organizer region)
→
correlates_with
→
Object:
tumor_grade
(Tumor grade)
Original: AgNOR number and relative area#correlated with#histological tumor grade
#11730
middle Confidence
Subject:
AgNORs
(Nucleolar Organizing Region Marker)
→
correlates_with
→
Object:
proliferation_index
(Proliferation activity index)
Original: AgNORs and PI correlation#decreases with#increasing histological differentiation
#11701
middle Confidence
Subject:
AgNOR
(Nucleolar Organizing Region-associated Protein)
→
is_important_for
→
Object:
prognostic_purposes
(Prognostic role)
Original: Distribution of AgNORs#is important for#diagnostic and prognostic purposes in tumor pathology
#11688
middle Confidence
Subject:
AgNOR_count
(Nucleolus count)
→
is_higher_in
→
Object:
tumor_with_lymphatic_invasion
(Tumor)
Original: DNA ploidy pattern and AgNOR count#are higher in#tumor tissues with lymphatic invasion
#11687
middle Confidence
Subject:
DNA_ploidy_pattern
(Cytogenetic characteristics)
→
is_higher_in
→
Object:
tumor_with_lymphatic_invasion
(Tumor)
Original: DNA ploidy pattern and AgNOR count#are higher in#tumor tissues with lymphatic invasion
#11656
middle Confidence
Subject:
ultrastructural_histologic_features
(Ultrastructural histological features)
→
may_predict
→
Object:
tumor_aggressiveness_in_prostate_cancer
(Tumor aggressiveness)
Original: ultrastructural histologic features#may predict#tumor aggressiveness in prostate cancer
#11655
middle Confidence
Subject:
grading_system
(Rating system)
→
may_provide
→
Object:
prognostic_value_for_lobular_carcinoma
(Prognostic value)
Original: grading system#may provide#prognostic value for lobular carcinoma
#11465
middle Confidence
Subject:
epithelioid_leiomyoblastoma
(Tumor type)
→
recurs_despite
→
Object:
low_AgNOR_count
(Molecular markers)
Original: Epithelioid leiomyoblastoma#recurred despite#a low AgNOR count
#11464
middle Confidence
Subject:
apoptotic_index
(Molecular markers)
→
is_associated_with
→
Object:
lower_chance_of_tumor_differentiation
(Tumor differentiation ability)
Original: High apoptotic index#was associated with#a lower chance of tumor differentiation
#11427
middle Confidence
Subject:
patient
(patient)
→
alive_at
→
Object:
mean_followup_19_months
(Follow-up time)
Original: 16 patients#were#alive at mean follow-up of 19 months
#10980
middle Confidence
Subject:
Hemophagocytic_lymphohistiocytosis
(disease)
→
is_reported_as
→
Object:
presenting_feature_in_37%_of_SPTCL_patients
(Clinical characteristics)
Original: Hemophagocytic lymphohistiocytosis#is reported as#the presenting feature in 37% of SPTCL patients
#10937
middle Confidence
Subject:
Silent_adrenocorticotropin_carcinomas
(Neoplastic diseases)
→
show
→
Object:
propensity_for_extraneural_dissemination
(Transfer Features)
Original: Silent adrenocorticotropin carcinomas#show#propensity for extraneural dissemination
#10792
middle Confidence
Subject:
clinical_and_histologic_features
(Clinical characteristics)
→
were_assessed_to_determine
→
Object:
predictive_value_for_malignancy
(Predictive Value)
Original: Numerous clinical and histologic features#were assessed to determine#their predictive value for malignancy
#10630
middle Confidence
Subject:
Silver_staining_technique
(Staining detection technology)
→
predictions
→
Object:
clinical_outcome_in_rectal_adenocarcinoma
(Clinical Outcomes)
Original: Silver staining technique#was investigated as#predictor of clinical outcome in rectal adenocarcinomas
#10615
middle Confidence
Subject:
micrograph_analysis
(Microscopic image analysis)
→
was_seen_to_be
→
Object:
relevant_for_prognosis
(Prognostic relevance)
Original: Histopathological grading and micrograph analysis#were seen to be#relevant for prognosis
#10614
middle Confidence
Subject:
histopathological_grading
(Histological grading)
→
was_seen_to_be
→
Object:
relevant_for_prognosis
(Prognostic relevance)
Original: Histopathological grading and micrograph analysis#were seen to be#relevant for prognosis
#10605
middle Confidence
Subject:
silver-stained_NOR_proteins
(Nucleolar Organizing Region-associated Protein)
→
are_related_with
→
Object:
proliferative_activity
(Cellular Processes)
Original: silver-stained proteins of interphase nucleolar organizer regions (NORs)#are related to#proliferative activity
#10355
middle Confidence
Subject:
lymph_node_metastasis
(Disease progression events)
→
not_detected_in
→
Object:
tub0_tubular_adenocarcinoma
(Tumor classification)
Original: No lymph node metastasis#was seen in#tub 0 cases
#10348
middle Confidence
Subject:
pituitary_neoplasm
(Tumor type)
→
has
→
Object:
low_metastatic_potential
(Disease phenotype)
Original: Pituitary neoplasms#have#a low metastatic potential
#9720
middle Confidence
Subject:
Prognostic_indicators
(Prognostic indicators)
→
include
→
Object:
AgNOR_count
(Nucleolar organizer region-associated protein count)
Original: Prognostic indicators#include#AgNOR count among others
#9680
middle Confidence
Subject:
AgNOR_analysis
(Molecular marker analysis)
→
is_considered_as
→
Object:
prognostic_parameter
(Prognostic parameters)
Original: AgNOR analysis#is considered#mainly as a prognostic parameter
#9672
middle Confidence
Subject:
Proliferative_activity
(Cellular Processes)
→
is_measured_by
→
Object:
AgNOR_count
(Molecular detection indicators)
Original: Proliferative activity#is measured by#Ki-67 Labelling Index and AgNOR count
#9671
middle Confidence
Subject:
Proliferative_activity
(Cellular Processes)
→
is_measured_by
→
Object:
Ki-67_labelling_index
(Molecular detection indicators)
Original: Proliferative activity#is measured by#Ki-67 Labelling Index and AgNOR count
#9551
middle Confidence
Subject:
one_case
(Case)
→
reported
→
Object:
adverse_event
(Adverse Events)
Original: Most cases#have done#well/ but one case reported an adverse event
#9550
middle Confidence
Subject:
most_cases
(Case)
→
have_done
→
Object:
well
(Prognosis)
Original: Most cases#have done#well/ but one case reported an adverse event
#9448
middle Confidence
Subject:
nuclear_features
(Cell morphology)
→
increase_with
→
Object:
tumor_grade
(Tumor grade)
Original: Pleomorphism and nuclear features#increase with#tumor grade
#9447
middle Confidence
Subject:
Pleomorphism
(Cell morphology)
→
increases_with
→
Object:
tumor_grade
(Tumor grade)
Original: Pleomorphism and nuclear features#increase with#tumor grade
#9129
middle Confidence
Subject:
HN
(Pathological stage)
→
progresses_to
→
Object:
hepatocellular_carcinoma
(Tumor diseases)
Original: HN#progressed toward#hepatocellular carcinoma
#8843
middle Confidence
Subject:
Metastasis
(Disease process)
→
is
→
Object:
not_uncommon_in_melanoma
(Epidemiological characteristics of the disease)
Original: Recurrences and metastases#are#not uncommon in melanoma
#8842
middle Confidence
Subject:
Recurrence
(Disease process)
→
is
→
Object:
not_uncommon_in_melanoma
(Epidemiological characteristics of the disease)
Original: Recurrences and metastases#are#not uncommon in melanoma
#8732
middle Confidence
Subject:
tumor_cells
(Tumor cells)
→
show
→
Object:
high_mitotic_rate
(High mitotic rate)
Original: Tumor cells#were#round/ epithelioid with vesicular nuclei/ large prominent nucleoli/ and high mitotic rate
#8706
middle Confidence
Subject:
patient
(patient)
→
died_of
→
Object:
pulmonary_metastases
(Disease phenotype)
Original: patient#died of#multiple pulmonary metastases
#8698
middle Confidence
Subject:
recurrence
(Disease progression)
→
developed_in
→
Object:
mediastinal_lymph_nodes
(Anatomical location)
Original: Recurrence#developed in#right cervical and mediastinal lymph nodes
#8697
middle Confidence
Subject:
recurrence
(Disease progression)
→
developed_in
→
Object:
right_cervical_lymph_nodes
(Anatomical location)
Original: Recurrence#developed in#right cervical and mediastinal lymph nodes
#8626
middle Confidence
Subject:
large_cell_morphology
(Cytological indicators)
→
is_associated_with
→
Object:
death_of_the_disease
(Clinical Outcomes)
Original: Patients with tumors of 25 mm or more/ showing mitoses of more than 6 per 10 high-power fields/ with abnormal forms/ necrosis/ and large cell morphology#died of#the disease
#8625
middle Confidence
Subject:
Necrosis
(Pathological characteristics)
→
is_associated_with
→
Object:
death_of_the_disease
(Clinical Outcomes)
Original: Patients with tumors of 25 mm or more/ showing mitoses of more than 6 per 10 high-power fields/ with abnormal forms/ necrosis/ and large cell morphology#died of#the disease
#8624
middle Confidence
Subject:
abnormal_forms
(Cytological indicators)
→
is_associated_with
→
Object:
death_of_the_disease
(Clinical Outcomes)
Original: Patients with tumors of 25 mm or more/ showing mitoses of more than 6 per 10 high-power fields/ with abnormal forms/ necrosis/ and large cell morphology#died of#the disease
#8623
middle Confidence
Subject:
mitoses_greater_than_6_per_10_HPF
(Cytological indicators)
→
is_associated_with
→
Object:
death_of_the_disease
(Clinical Outcomes)
Original: Patients with tumors of 25 mm or more/ showing mitoses of more than 6 per 10 high-power fields/ with abnormal forms/ necrosis/ and large cell morphology#died of#the disease
#8622
middle Confidence
Subject:
tumors_of_25mm_or_more
(Tumor phenotype)
→
is_associated_with
→
Object:
death_of_the_disease
(Clinical Outcomes)
Original: Patients with tumors of 25 mm or more/ showing mitoses of more than 6 per 10 high-power fields/ with abnormal forms/ necrosis/ and large cell morphology#died of#the disease
#8539
middle Confidence
Subject:
patient
(patient)
→
died_after
→
Object:
8_months_after_diagnosis
(Survival)
Original: Patient#did not respond well to#chemotherapy and died 8 months after diagnosis
#8358
middle Confidence
Subject:
type_A_thymoma
(Tumor tissue)
→
has
→
Object:
prognostic_aspects
(Prognostic features)
Original: type A thymoma#has#cytologic differential diagnosis and prognostic aspects
#7559
middle Confidence
Subject:
lesion
(Pathological morphological features)
→
disappears_after
→
Object:
needling
(Cytological sampling techniques)
Original: many lesions#regress or disappear after#needling
#7558
middle Confidence
Subject:
lesion
(Pathological morphological features)
→
regresses_after
→
Object:
needling
(Cytological sampling techniques)
Original: many lesions#regress or disappear after#needling
#7073
middle Confidence
Subject:
prognostic_groups
(Prognostic groups)
→
are_identified_by
→
Object:
cell_morphology_in_CTCL
(Cell morphological characteristics)
Original: prognostic groups#are identified by#cell morphology in CTCL
#6739
middle Confidence
Subject:
Imaging
(Diagnostic techniques)
→
revealed
→
Object:
disseminated_metastases
(Metastatic phenotype)
Original: Imaging#revealed#a perforated jejunal mass with disseminated metastases
#6561
middle Confidence
Subject:
AgNOR
(Nucleolar Organizing Region-associated Protein)
→
is_observed_in
→
Object:
grade_3_carcinomas
(Pathological grading)
Original: High AgNOR counts#are observed in#late stage tumors/ grade 3 carcinomas/ and tumors with poor chemotherapy response
#6560
middle Confidence
Subject:
AgNOR
(Nucleolar Organizing Region-associated Protein)
→
is_observed_in
→
Object:
late_stage_tumors
(Tumor stage)
Original: High AgNOR counts#are observed in#late stage tumors/ grade 3 carcinomas/ and tumors with poor chemotherapy response
#6559
middle Confidence
Subject:
AgNOR
(Nucleolar Organizing Region-associated Protein)
→
correlates_with
→
Object:
biologic_behavior
(Biological behavior)
Original: AgNOR count#correlates with#clinical stage/ histologic grade/ response to chemotherapy/ and biologic behavior
#6557
middle Confidence
Subject:
AgNOR
(Nucleolar Organizing Region-associated Protein)
→
correlates_with
→
Object:
histologic_grade
(Pathological grading)
Original: AgNOR count#correlates with#clinical stage/ histologic grade/ response to chemotherapy/ and biologic behavior
#6556
middle Confidence
Subject:
AgNOR
(Nucleolar Organizing Region-associated Protein)
→
correlates_with
→
Object:
clinical_stage
(Tumor stage)
Original: AgNOR count#correlates with#clinical stage/ histologic grade/ response to chemotherapy/ and biologic behavior
#6258
middle Confidence
Subject:
nuclear_size
(Nuclear size)
→
is_associated_with
→
Object:
TLI_trend
(Tumor proliferation index trend)
Original: increasing histologic grades and nuclear size#are associated with#increasing TLI trends
#6257
middle Confidence
Subject:
histologic_grade
(Histological grading)
→
is_associated_with
→
Object:
TLI_trend
(Tumor proliferation index trend)
Original: increasing histologic grades and nuclear size#are associated with#increasing TLI trends
#6196
middle Confidence
Subject:
CIN3
(Pathological grading)
→
is_associated_with
→
Object:
microinvasive_carcinoma
(Tumor type)
Original: CIN3 associated with microinvasive carcinoma#shows#extensive involvement of surface epithelium and deep endocervical crypts
#6191
middle Confidence
Subject:
malignancy_progression
(Tumor progression)
→
is_characterized_by
→
Object:
modifications_to_capillaries_of_stroma
(Stromal capillary changes)
Original: Process of malignancy progression#is characterized by#a gradual and continuous derangement of cell characteristics and modifications to capillaries of the stroma
#6190
middle Confidence
Subject:
malignancy_progression
(Tumor progression)
→
is_characterized_by
→
Object:
derangement_of_cell_characteristics
(Abnormal cell characteristics)
Original: Process of malignancy progression#is characterized by#a gradual and continuous derangement of cell characteristics and modifications to capillaries of the stroma
#6131
middle Confidence
Subject:
AgNOR_counts
(Cell proliferation markers)
→
are_related_to
→
Object:
survival_time
(Survival)
Original: AgNOR counts#are related to#histological grade and survival time in canine malignant lymphomas
#6130
middle Confidence
Subject:
AgNOR_counts
(Cell proliferation markers)
→
are_related_to
→
Object:
histological_grade
(Pathological grading)
Original: AgNOR counts#are related to#histological grade and survival time in canine malignant lymphomas
#5714
middle Confidence
Subject:
NOR_frequency
(Molecular markers)
→
correlates_with
→
Object:
patient_survival
(Survival)
Original: NOR frequency#was correlated with#adenoma diameter/ carcinoma stage/ tumor recurrence/ and patient survival
#5713
middle Confidence
Subject:
NOR_frequency
(Molecular markers)
→
correlates_with
→
Object:
tumor_recurrence
(relapse)
Original: NOR frequency#was correlated with#adenoma diameter/ carcinoma stage/ tumor recurrence/ and patient survival
#5617
middle Confidence
Subject:
grade_of_FLAC
(Tumor grade)
→
explains
→
Object:
discrepancies_in_clinicopathologic_features
(Differences in clinicopathological features)
Original: High and low grades of FLAC#explain#discrepancies in clinicopathologic features
#5142
middle Confidence
Subject:
patients
(patient)
→
experienced
→
Object:
recurrence_due_to_residual_tumor
(Clinical Outcomes)
Original: patients#experienced#recurrence due to a residual tumor
#5005
middle Confidence
Subject:
proliferative_potential_of_VC
(Proliferation Potential)
→
was_evaluated_by
→
Object:
malignancy_degree
(Malignancy)
Original: Proliferative potential of VC#was evaluated by#AgNOR and correlated with malignancy degree
#4713
middle Confidence
Subject:
tumor_cells
(Tumor cells)
→
associated_with
→
Object:
shorter_clinical_course
(Disease progression)
Original: tumor cells#have#irregular nuclei/ protruding nucleoli/ advanced stage at diagnosis/ and shorter clinical course
#4712
middle Confidence
Subject:
tumor_cells
(Tumor cells)
→
present_at
→
Object:
advanced_stage_at_diagnosis
(Disease Stage)
Original: tumor cells#have#irregular nuclei/ protruding nucleoli/ advanced stage at diagnosis/ and shorter clinical course
#4161
low Confidence
Subject:
clinical_outcome
(Clinical Outcomes)
→
correlated_with
→
Object:
histopathologic_followup
(Pathological follow-up)
Original: Clinical outcome and histopathologic follow-up#were reviewed and correlated for#COS
#4158
low Confidence
Subject:
male_patient
(Patient characteristics)
→
showed_no_recurrence_of
→
Object:
tumor
(Tumor type)
Original: Male patient#showed no recurrence of#tumor at nine years
#4049
low Confidence
Subject:
ultrastructural_grading_system
(Rating system)
→
may_determine
→
Object:
prognosis
(Disease phenotype)
Original: ultrastructural grading system#may determine#prognosis in prostatic cancer
#3987
low Confidence
Subject:
Pleomorphic_adenoma
(Benign tumors)
→
rarely_metastasizes_to
→
Object:
distant_sites
(Tumor metastasis)
Original: Pleomorphic adenoma (PA)#is considered#benign tumor which may recur and rarely metastasize
#3980
low Confidence
Subject:
silver_stained_nucleolar_organizer_regions
(Molecular structure labeling)
→
validate
→
Object:
PKI_for_prognosis_in_CLLPD
(Molecular analysis indicators)
Original: Diploid histogram parameters and silver-stained nucleolar organizer regions#validate#PKI for prognosis in CLLPD
#3979
low Confidence
Subject:
diploid_histogram_parameters
(Molecular analysis parameters)
→
validate
→
Object:
PKI_for_prognosis_in_CLLPD
(Molecular analysis indicators)
Original: Diploid histogram parameters and silver-stained nucleolar organizer regions#validate#PKI for prognosis in CLLPD
#3806
low Confidence
Subject:
male_patient
(patient)
→
developed
→
Object:
bone_metastases
(Metastatic disease)
Original: Two men#developed#bone metastases without biopsy
#3682
low Confidence
Subject:
patient
(patient)
→
was_alive
→
Object:
nine_months_after_discharge
(Survival)
Original: patient#was alive#nine months after discharge
#3646
low Confidence
Subject:
uterine_cervical_relapse
(Disease recurrence)
→
is_associated_with
→
Object:
B-cell_acute_lymphoblastic_leukemia
(disease)
Original: Uterine cervical relapse#is associated with#B-cell acute lymphoblastic leukemia (ALL)
#3613
low Confidence
Subject:
Peripheral_myxoid_hamartoma_with_neural_differentiation
(Tumor type)
→
is_expected_to_have
→
Object:
benign_clinical_course
(Disease Prognosis)
Original: Peripheral myxoid hamartoma with neural differentiation#is expected to have#a benign clinical course
#3553
low Confidence
Subject:
one_patient
(patient)
→
is_alive_without_evidence_of
→
Object:
sarcoma
(Tumor type)
Original: one patient#is alive#without evidence of disease at 10 years
#3552
low Confidence
Subject:
one_patient
(patient)
→
is_alive_without_evidence_of
→
Object:
liver_metastasis
(Transfer)
Original: one patient#is alive#without evidence of disease at 10 years
#3551
low Confidence
Subject:
one_patient
(patient)
→
is_alive_without_evidence_of
→
Object:
disease_at_10_years
(Survival Outcome)
Original: one patient#is alive#without evidence of disease at 10 years
#3406
low Confidence
Subject:
tumor
(Tumor tissue)
→
did_not_metastasize_after
→
Object:
excision
(Surgical resection)
Original: Tumors#did not recur or metastasize after#excision
#3405
low Confidence
Subject:
tumor
(Tumor tissue)
→
did_not_recur_after
→
Object:
excision
(Surgical resection)
Original: Tumors#did not recur or metastasize after#excision
#3352
low Confidence
Subject:
patients
(patient)
→
died_within
→
Object:
1_year_after_onset_of_skin_lesions
(Survival Outcome)
Original: Most patients#died within#1 year after onset of skin lesions
#3102
low Confidence
Subject:
malignant_peripheral_nerve_sheath_tumor
(Tumor type)
→
was_studied_for
→
Object:
biologic_behavior
(Biological behavior)
Original: malignant peripheral nerve sheath tumor#was studied for#histologic patterns/ immunophenotype/ and biologic behavior
#2930
low Confidence
Subject:
molecular_targets
(Molecular targets)
→
provide
→
Object:
prognostic_strategies_for_thyroid_cancer
(Prognosis)
Original: Molecular targets#could provide#opportunities for diagnostic/ prognostic/ and treatment strategies for thyroid cancer
#2719
low Confidence
Subject:
primary_examination_data_of_TCTUB_patients
(Clinical Data)
→
were_studied_for
→
Object:
survival
(Survival)
Original: data on primary examination and 5-year follow-up of patients with TCTUB#were studied for#tumor recurrence and survival
#2718
low Confidence
Subject:
primary_examination_data_of_TCTUB_patients
(Clinical Data)
→
were_studied_for
→
Object:
tumor_recurrence
(Disease phenotype)
Original: data on primary examination and 5-year follow-up of patients with TCTUB#were studied for#tumor recurrence and survival
#2577
low Confidence
Subject:
factors
(Clinical factors)
→
might_contribute_to
→
Object:
clinical_outcomes_in_ureteropelvic_TCC
(Clinical Outcomes)
Original: Factors#might contribute#to clinical outcomes in ureteropelvic TCC patients
#2544
low Confidence
Subject:
PLC
(Tumor subtype)
→
was_not_significantly_different_from
→
Object:
classic_ILC
(Tumor subtype)
Original: No significant differences#were found between#PLC and classic ILC for axillary lymph node/distant metastases and survival
#2403
low Confidence
Subject:
Six_patients
(Patient population)
→
had_no
→
Object:
recurrence
(Disease phenotype)
Original: Six patients#had no#recurrence
#2131
low Confidence
Subject:
apoptosis
(Cellular Processes)
→
interacts_with
→
Object:
laboratory_parameters
(Laboratory parameters)
Original: apoptosis#interacts with#clinical and laboratory parameters
#2130
low Confidence
Subject:
apoptosis
(Cellular Processes)
→
interacts_with
→
Object:
clinical_parameters
(Clinical parameters)
Original: apoptosis#interacts with#clinical and laboratory parameters
#1913
low Confidence
Subject:
personal_history_of_melanoma
(Medical history characteristics)
→
is_present_in
→
Object:
patients_with_mild_atypia
(Patient subgroups)
Original: personal history of melanoma#was present in#patients with mild/ moderate/ and severe atypia
#1849
low Confidence
Subject:
six_cases
(Case)
→
are_reported_with
→
Object:
poor_outcomes
(Clinical Outcomes)
Original: Six cases#are reported with#poor outcomes
#1427
low Confidence
Subject:
survival_period
(Clinical Outcomes)
→
was_average_of
→
Object:
16.1_months
(Survival)
Original: survival period#was an average of#16.1 months
#1255
low Confidence
Subject:
One_patient
(Patient population)
→
had_distant_metastases_to
→
Object:
liver
(organ)
Original: One patient#had distant#metastases to the liver
#1254
low Confidence
Subject:
Four_patients
(Patient population)
→
had_spread_to
→
Object:
regional_lymph_nodes
(Organizational Structure)
Original: Four patients#had spread to#the regional lymph nodes
#1253
low Confidence
Subject:
Three_patients
(Patient population)
→
had_local
→
Object:
recurrence_in_the_form_of_satellite_nodules_adjacent_to_the_scar
(Disease phenotype)
Original: Three patients#had local#recurrence in the form of satellite nodules adjacent to the scar
#1203
low Confidence
Subject:
IBS_type
(Disease subtype)
→
showed
→
Object:
less_favorable_prognosis
(Prognostic features)
Original: LP type#showed#a more favorable prognosis than IBS type
#1202
low Confidence
Subject:
LP_type
(Disease subtype)
→
showed
→
Object:
more_favorable_prognosis
(Prognostic features)
Original: LP type#showed#a more favorable prognosis than IBS type
#644
low Confidence
Subject:
MDM2_positive_cells
(Protein expressing cells)
→
correlates_with
→
Object:
epithelial_dysplasia_degree
(Pathological grading)
Original: Correlation between percentage of p53 and MDM2-positive cells#was established#regardless of epithelial dysplasia degree
#643
low Confidence
Subject:
p53_positive_cells
(Protein expressing cells)
→
correlates_with
→
Object:
epithelial_dysplasia_degree
(Pathological grading)
Original: Correlation between percentage of p53 and MDM2-positive cells#was established#regardless of epithelial dysplasia degree
#634
low Confidence
Subject:
mean_AgNOR_counts
(AgNOR Count)
→
indicate
→
Object:
prognostic_value
(Prognostic value)
Original: mean AgNOR counts for odontogenic cysts and ameloblastomas#indicate#neither diagnostic nor prognostic value
#437
low Confidence
Subject:
death
(Clinical Outcomes)
→
occurred_in
→
Object:
cases_studied
(Patient samples)
Original: death#occurred in#13 of 14 cases studied
#174
low Confidence
Subject:
AgNOR
(Nucleolar Organizing Region-associated Protein)
→
prognostic_value_not_well_defined_in
→
Object:
epithelial_ovarian_carcinoma
(Tumor type)
Original: The prognostic value of AgNORs#has not been well defined in#epithelial ovarian carcinomas
#18
low Confidence
Subject:
Most_markers
(Molecular markers)
→
are_not_easily_applicable_for
→
Object:
prognosis
(Prognosis)
Original: Most markers#are not#easily applicable for prognosis