临床相关性：Resistance mechanisms
A total of 7 records found
#20526
high Confidence
Subject:
MDMX
(protein)
→
promotes
→
Object:
resistance_to_5_fluorouracil
(Drug resistance)
Original: MDMX expression#promotes#resistance to 5-fluorouracil
#19065
middle Confidence
Subject:
NFE2L2_activation
(Transcription factor activation)
→
upregulates
→
Object:
ABCC1
(Transporter)
Original: Ubiquitinated aggregates of p62 and KEAP1#induce#NRF2 activation and MRP1 upregulation/ leading to chemoresistance
#18968
middle Confidence
Subject:
Heat_shock_proteins
(Molecular chaperone proteins)
→
are_involved_in
→
Object:
anti-cancer_drug_resistance
(Chemotherapy resistance)
Original: Heat shock proteins (Hsps)#are induced by#cytotoxic drugs and involved in anti-cancer drug resistance
#18967
middle Confidence
Subject:
Heat_shock_proteins
(Molecular chaperone proteins)
→
are_induced_by
→
Object:
cytotoxic_drugs
(Chemotherapy drugs)
Original: Heat shock proteins (Hsps)#are induced by#cytotoxic drugs and involved in anti-cancer drug resistance
#16725
middle Confidence
Subject:
Nucleolar_asynchrony
(Nucleolar status)
→
represented
→
Object:
myeloblasts_resistant_to_HDACi_treatment
(Drug-resistant leukemic blasts)
Original: Nucleolar asynchrony#represents#myeloblasts resistant to HDACi treatment
#12320
middle Confidence
Subject:
ABCC1
(Transporter)
→
is_upregulated_in
→
Object:
rhabdoid_cells
(Cell Type)
Original: NRF2 and MRP1 overexpression#were observed in#rhabdoid cells
#12319
middle Confidence
Subject:
NFE2L2
(Transcription Factors)
→
is_upregulated_in
→
Object:
rhabdoid_cells
(Cell Type)
Original: NRF2 and MRP1 overexpression#were observed in#rhabdoid cells