临床相关性：Transcriptional regulatory mechanisms

A total of 6 records found

#19050 middle Confidence
Subject: UBF1-mediated_ECT2_recruitment (Protein complex assembly)
→ elevates →
Object: rRNA_synthesis (Transcription product)
Original: UBF1-mediated ECT2 recruitment#elevates#rRNA synthesis
🏥 Transcriptional regulatory mechanisms 🧬 UBTF/ECT2 📄 PMID: 32350115
Details
#19049 middle Confidence
Subject: ECT2 (Guanine nucleotide exchange factor)
→ activates →
Object: rDNA_transcription (Transcription process)
Original: ECT2#activates#rDNA transcription
🏥 Transcriptional regulatory mechanisms 🧬 ECT2 📄 PMID: 32350115
Details
#16796 middle Confidence
Subject: USP36 (Deubiquitinase)
→ Deubiquitinates →
Object: c-Myc (Transcription Factors)
Original: USP36#interacts with and deubiquitinates#c-Myc
🏥 Transcriptional regulatory mechanisms 🧬 USP36/MYC 📄 PMID: 25775507
Details
#16795 middle Confidence
Subject: USP36 (Deubiquitinase)
→ interacts_with →
Object: c-Myc (Transcription Factors)
Original: USP36#interacts with and deubiquitinates#c-Myc
🏥 Transcriptional regulatory mechanisms 🧬 USP36/MYC 📄 PMID: 25775507
Details
#12296 middle Confidence
Subject: UBF1_Ser-412_phosphorylation_site (Protein modification sites)
→ is_required_for →
Object: UBF1-mediated_ECT2_recruitment_to_rDNA (Protein complex assembly)
Original: UBF1 Ser-412 phosphorylation site#is required for#UBF1-mediated ECT2 recruitment to rDNA
🏥 Transcriptional regulatory mechanisms 🧬 UBTF/ECT2 📄 PMID: 32350115
Details
#12295 middle Confidence
Subject: ECT2 (Guanine nucleotide exchange factor)
→ binds_to →
Object: UBF1 (Transcription Factors)
Original: ECT2#binds#UBF1 on rDNA promoter regions
🏥 Transcriptional regulatory mechanisms 🧬 ECT2/UBTF 📄 PMID: 32350115
Details