Triple #12313
middle ConfidenceKnowledge triple
MDMX
Protein regulatory factors
Level 2
→
reduces_sensitivity_to
Negative regulatory relationship
→
actinomycin_D-induced_growth_arrest
Drug action phenotype
Level 11
Original triple： Tumor cells overexpressing MDMX#are less sensitive to#actinomycin D-induced growth arrest
Evidence and Confidence
| Confidence: | middle |
| Evidence Strength: | Experimental + Clinical |
| Condition Dependency: | actinomycin_D |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Treatment related |
Other Info
| PMID: | 17110929 ↗ |
| Knowledge Particle: | KP3 |
| Value Leadboard: | 6 |
| Gene Symbol: | MDMX |
| Disease: | Tumor |
| Treatment: | Actinomycin D |