Triple #12731
middle ConfidenceKnowledge triple
IL2_STAT5_signaling_pathway
signaling pathway
Level 5
→
is_upregulated_in
Positive Regulation
→
high_CAF_infiltration
Tumor microenvironment characteristics
Level 9
Original triple： pathways such as allograft rejection/ epithelial-mesenchymal transition/ KRAS signaling#were upregulated in#patients with high CAF infiltration
Evidence and Confidence
| Confidence: | middle |
| Evidence Strength: | Multi-omics analysis |
| Condition Dependency: | Patients with high CAF infiltration |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Immunomodulation |
Other Info
| PMID: | 37186041 ↗ |
| Knowledge Particle: | KP6 |
| Value Leadboard: | 3 |
| Gene Symbol: | KRAS |
| Disease: | Lung cancer |
| Pathway: | Allograft rejection/ epithelial-mesenchymal transition/ KRAS signaling/ TNF-α signaling/ myogenesis/ IL6/JAK/STAT3 signaling/ IL2/STAT5 signaling |