Triple #16090
middle ConfidenceKnowledge triple
MDM2
Ubiquitin ligase
Level 2
→
decreased_interaction_with
Negative regulatory relationship
→
p19(ARF)
Cell cycle regulatory proteins
Level 2
Original triple： elevated levels of p53 after TIF-IA depletion#are due to#increased binding of ribosomal proteins (e.g./ L11) to MDM2 and decreased interaction of MDM2 with p53 and p19(ARF)
Evidence and Confidence
| Confidence: | middle |
| Evidence Strength: | experiment |
| Condition Dependency: | TIF-IA deficiency |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | not_specified |
Other Info
| PMID: | 15989966 ↗ |
| Knowledge Particle: | KP3 |
| Value Leadboard: | 6 |
| Gene Symbol: | TP53/RPL11/MDM2/CDKN2A |