Triple #16792
middle ConfidenceKnowledge triple
inhibition_of_PARylation_of_DDX21
Protein modification
Level 3
→
mislocalizes
Protein localization relationship
→
DDX21_to_nucleoplasm
Protein subcellular localization
Level 3
Original triple： Inhibition of PARP1-mediated ADPRylation of DDX21 by niraparib#mislocalizes#DDX21 to nucleoplasm
Evidence and Confidence
| Confidence: | middle |
| Evidence Strength: | experiment |
| Condition Dependency: | Niraparib treatment |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Treatment Mechanism |
Other Info
| PMID: | 38767454 ↗ |
| Knowledge Particle: | KP3 |
| Value Leadboard: | 6 |
| Gene Symbol: | DDX21 |
| Disease: | Endometrial cancer/ Ovarian cancer |
| Treatment: | Niraparib |