Triple #16793
middle ConfidenceKnowledge triple
mislocalization_of_DDX21
Abnormal protein localization
Level 3
→
leads_to
causation
→
reduction_in_ribosome_biogenesis
Ribosome biogenesis
Level 4
Original triple： Mislocalization of DDX21#leads to#reduction in ribosome biogenesis and cancer cell growth
Evidence and Confidence
| Confidence: | middle |
| Evidence Strength: | experiment |
| Condition Dependency: | PARP inhibitor treatment |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Nucleolar stress |
Other Info
| PMID: | 38767454 ↗ |
| Knowledge Particle: | KP3 |
| Value Leadboard: | 6 |
| Gene Symbol: | DDX21 |
| Disease: | Endometrial cancer/ Ovarian cancer |
| Treatment: | Niraparib |