Triple #16921
middle ConfidenceKnowledge triple
KEAP1
Redox regulatory proteins
Level 2
→
induces
Positive regulatory relationship
→
NFE2L2_activation
Transcription factor activation
Level 3
Original triple： Ubiquitinated aggregates of p62 and KEAP1#induce#NRF2 activation and MRP1 upregulation/ leading to chemoresistance
Evidence and Confidence
| Confidence: | middle |
| Evidence Strength: | experiment |
| Condition Dependency: | not_specified |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | not_specified |
Other Info
| PMID: | 25031015 ↗ |
| Knowledge Particle: | KP3 |
| Value Leadboard: | 6 |
| Gene Symbol: | SQSTM1/ KEAP1/ NFE2L2/ ABCC1 |
| Disease: | Anaplastic carcinoma |