Triple #17015
middle ConfidenceKnowledge triple
NPM1
Nucleolar proteins
Level 2
→
blocks
Negative regulatory relationship
→
increases_in_Arf(-/-)_osteoclast_activity
Cellular Processes
Level 6
Original triple： Knockdown of NPM#blocks#increases in Arf(-/-) ribosome output and osteoclast activity
Evidence and Confidence
| Confidence: | middle |
| Evidence Strength: | experiment |
| Condition Dependency: | ARF deletion |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | not_specified |
Other Info
| PMID: | 18070929 ↗ |
| Knowledge Particle: | KP4 |
| Value Leadboard: | 7 |
| Gene Symbol: | npm1/cdkn2a |
| Cell Type: | Osteoclasts |
| Pathway: | Ribosome biogenesis |