Triple #17020
middle ConfidenceKnowledge triple
POLR1A
RNA polymerase I subunit
Level 2
→
downregulation_inactivates
Negative regulatory relationship
→
MDM2-mediated_p53_degradation
Protein degradation process
Level 3
Original triple： Downregulation of rRNA synthesis#inactivates#MDM2-mediated p53 degradation
Evidence and Confidence
| Confidence: | middle |
| Evidence Strength: | experiment |
| Condition Dependency: | rRNA_synthesis_downregulation |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | not_specified |
Other Info
| PMID: | 21399665 ↗ |
| Knowledge Particle: | KP4 |
| Value Leadboard: | 7 |
| Gene Symbol: | POLR1A/TP53/MDM2 |
| Disease: | Human cancer |