Triple #19146
middle ConfidenceKnowledge triple
APE1
DNA repair enzymes
Level 2
→
accumulates_in
Positioning relationship
→
Cytoplasm
Subcellular structure
Level 3
Original triple： Expression of NPM1c+ variant#causes#cytoplasmic accumulation of APE1 in HeLa cells/ OCI/AML3 cells/ and primary lymphoblasts
Evidence and Confidence
| Confidence: | middle |
| Evidence Strength: | experiment |
| Condition Dependency: | HeLa/OCI-AML3/lymphoblasts |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Pathogenic mechanism |
Other Info
| PMID: | 23831574 ↗ |
| Knowledge Particle: | KP4 |
| Value Leadboard: | 7 |
| Gene Symbol: | NPM1/APE1 |
| Cell Type: | HeLa cells/OCI/AML3 cells/lymphoblasts |
| Disease: | Acute myeloid leukemia (AML) |
| Pathway: | Cytoplasmic localization |