Triple #19779
middle ConfidenceKnowledge triple
TIF-IA_depletion
Gene expression regulation
Level 3
→
leads_to
causation
→
elevated_p53_levels
Protein expression
Level 2
Original triple： elevated levels of p53 after TIF-IA depletion#are due to#increased binding of ribosomal proteins (e.g./ L11) to MDM2 and decreased interaction of MDM2 with p53 and p19(ARF)
Evidence and Confidence
| Confidence: | middle |
| Evidence Strength: | experiment |
| Condition Dependency: | not_specified |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | not_specified |
Other Info
| PMID: | 15989966 ↗ |
| Knowledge Particle: | KP3 |
| Value Leadboard: | 6 |
| Gene Symbol: | TP53/RPL11/MDM2/CDKN2A |