Triple #20075
high ConfidenceKnowledge triple
guanine_nucleotide
Small molecule metabolites
Level 0
→
depletion
causation
→
45S_precursor_rRNA_synthesis
rRNA transcription synthesis
Level 3
Original triple： Depletion of guanine nucleotides by MPA and AVN-944#causes#a reduction in levels of 45S precursor rRNA synthesis
Evidence and Confidence
| Confidence: | high |
| Evidence Strength: | Experimental + Clinical |
| Condition Dependency: | Drug treatment |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Treatment related |
Other Info
| PMID: | 17462731 ↗ |
| Knowledge Particle: | KP4 |
| Value Leadboard: | 7 |
| Treatment: | MPA/AVN-944 |