Triple #20294
high ConfidenceKnowledge triple
MDM2
Ubiquitin ligase
Level 2
→
abrogates
Negative regulatory relationship
→
p53-mediated_G1_arrest
Molecular modification regulation
Level 3
Original triple： MDM2 oncoprotein#abrogates#p53-mediated G1 arrest and apoptosis
Evidence and Confidence
| Confidence: | high |
| Evidence Strength: | experiment |
| Condition Dependency: | not_specified |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Cell cycle regulation |
Other Info
| PMID: | 10951578 ↗ |
| Knowledge Particle: | KP5 |
| Value Leadboard: | 1 |
| Gene Symbol: | MDM2/ TP53 |