Triple #20360
high ConfidenceKnowledge triple
Actinomycin_D
Chemotherapy drugs
Level 11
→
induces
Positive regulatory relationship
→
reorganization_of_nucleolar_components
Subcellular structural changes
Level 2
Original triple： Actinomycin D (AMD)#induces#reorganization of nucleolar components by inhibiting rRNA synthesis
Evidence and Confidence
| Confidence: | high |
| Evidence Strength: | Experimental + Clinical |
| Condition Dependency: | rRNA synthesis inhibition conditions |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Treatment Mechanism |
Other Info
| PMID: | 29190286 ↗ |
| Knowledge Particle: | KP2 |
| Value Leadboard: | 5 |
| Treatment: | Actinomycin D |
| Pathway: | rRNA synthesis inhibition |