Triple #20361
high ConfidenceKnowledge triple
DHODH
Enzymes
Level 2
→
inhibition_impairs
Negative regulatory relationship
→
rDNA_transcription
Transcription process
Level 3
Original triple： DHODH inhibition#impaired#rDNA transcription/ leading to nucleolar stress
Evidence and Confidence
| Confidence: | high |
| Evidence Strength: | Experimental + Pharmacology |
| Condition Dependency: | glioblastoma_cells |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Treatment Mechanism |
Other Info
| PMID: | 33201894 ↗ |
| Knowledge Particle: | KP2 |
| Value Leadboard: | 5 |
| Gene Symbol: | DHODH |
| Disease: | Glioblastoma |
| Treatment: | Brequinar/ ML390 |