Triple #20379
high ConfidenceKnowledge triple
CX5461
Small molecule inhibitors
Level 11
→
disrupts
Negative regulatory relationship
→
nucleolar_integrity
Subcellular structure
Level 3
Original triple： CX5461#disrupts#nucleolar integrity by targeting RNAPOL1
Evidence and Confidence
| Confidence: | high |
| Evidence Strength: | Experimental + Clinical |
| Condition Dependency: | Targeting RNAPOL1 |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Treatment Mechanism |
Other Info
| PMID: | 35673898 ↗ |
| Knowledge Particle: | KP3 |
| Value Leadboard: | 6 |
| Gene Symbol: | POLR1 |
| Treatment: | CX5461 |