Triple #21553
high ConfidenceKnowledge triple
DHODH
Enzymes
Level 2
→
inhibition_depletes
Functional relationship
→
pyrimidine_pool
Metabolites
Level 0
Original triple： Pharmacological inhibition of DHODH#depleted#the pool of pyrimidines in glioblastoma cells
Evidence and Confidence
| Confidence: | high |
| Evidence Strength: | Experimental + Pharmacology |
| Condition Dependency: | glioblastoma_cells |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Treatment Mechanism |
Other Info
| PMID: | 33201894 ↗ |
| Knowledge Particle: | KP2 |
| Value Leadboard: | 5 |
| Gene Symbol: | DHODH |
| Cell Type: | Glioblastoma cells |
| Disease: | Glioblastoma |
| Treatment: | Brequinar/ ML390 |