Triple #21568
high ConfidenceKnowledge triple
Niraparib
PARP inhibitors
Level 11
→
inhibits
Negative regulatory relationship
→
PARP1-mediated_ADPRylation_of_DDX21
Protein modification
Level 3
Original triple： Inhibition of PARP1-mediated ADPRylation of DDX21 by niraparib#mislocalizes#DDX21 to nucleoplasm
Evidence and Confidence
| Confidence: | high |
| Evidence Strength: | Experimental + Clinical |
| Condition Dependency: | not_specified |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Treatment Mechanism |
Other Info
| PMID: | 38767454 ↗ |
| Knowledge Particle: | KP3 |
| Value Leadboard: | 6 |
| Gene Symbol: | DDX21 |
| Disease: | Endometrial cancer/ Ovarian cancer |
| Treatment: | Niraparib |