Triple #21881
high ConfidenceKnowledge triple
BRG1_loss
Loss of protein expression
Level 2
→
diagnoses
Diagnostic relationship
→
SMARCA4_deficient_esophageal_carcinoma
Tumor type
Level 10
Original triple： SMARCA4 deficient esophageal carcinoma#was diagnosed based on#loss of BRG1 by immunostain and deep deletion confirmed by next-generation sequencing
Evidence and Confidence
| Confidence: | high |
| Evidence Strength: | Clinical + genetic testing |
| Condition Dependency: | NGS/Immunohistochemistry |
| Fact or Inference: | Fact |
Clinical Relevance
| Clinical Relevance: | Diagnostic significance |
Other Info
| PMID: | 37459679 ↗ |
| Knowledge Particle: | KP9 |
| Value Leadboard: | 4 |
| Gene Symbol: | SMARCA4 |
| Disease: | Esophageal carcinoma |