临床相关性：Tumor progression
A total of 34 records found
#22111
high Confidence
Subject:
hyperactivation_of_ribosome_biogenesis
(Molecular Process)
→
drives
→
Object:
cancer_progression
(Tumor progression)
Original: Hyperactivation of ribosome biogenesis#drives#cancer progression
#22110
high Confidence
Subject:
Breast cancer stem cells
(Cancer stem cells)
→
are_key_players_in
→
Object:
development (tumor progression)
(Tumor progression)
Original: Breast cancer stem cells#are key players in#carcinogenesis and development
#21685
high Confidence
Subject:
pleomorphic_adenoma
(Benign adenoma)
→
progresses_to
→
Object:
adenocarcinoma
(Adenocarcinoma)
Original: Adenoma#progresses to#adenocarcinoma
#21590
high Confidence
Subject:
DCAF13
(Ubiquitin ligase)
→
enhances
→
Object:
cell_proliferation
(Cell proliferation)
Original: DCAF13#enhances#Pol I transcription and proliferation in BC cells
#21588
high Confidence
Subject:
assembly_and_maturation_factors
(Ribosome assembly factor)
→
are_upregulated_in
→
Object:
Breast_Cancer
(disease)
Original: Assembly and maturation factors (AMFs)#are upregulated in#Breast Cancer
#21587
high Confidence
Subject:
K63-linked_ubiquitination_of_POLR1A
(Protein modification)
→
promotes
→
Object:
uncontrolled_proliferation
(Cell proliferation)
Original: DCAF13-mediated K63-linked ubiquitination of RNA polymerase I#promotes#uncontrolled proliferation in Breast Cancer
#20421
high Confidence
Subject:
Nucleolin lactylation
(Protein post-translational modification)
→
promotes
→
Object:
invasion of iCCA cells
(Cellular Processes)
Original: Nucleolin lactylation#promotes#invasion of iCCA cells
#20318
high Confidence
Subject:
microinvasive_carcinoma
(Cancer Type)
→
invades
→
Object:
connective_tissue
(Organization Type)
Original: Histopathological examination#shows#microinvasive carcinoma invading connective tissue
#19965
middle Confidence
Subject:
nucleolar_NPM_expression
(Protein expression characteristics)
→
is_associated_with
→
Object:
tumor_progression
(Tumor progression)
Original: Increased nucleolar NPM expression#is associated with#tumor progression
#19216
middle Confidence
Subject:
Brachyury
(Transcription Factors)
→
plays_role_in
→
Object:
cancer_progression
(Tumor progression)
Original: Brachyury#plays#a role in cancer progression
#19166
middle Confidence
Subject:
tumor-associated_macrophages
(Immune cells)
→
mediate
→
Object:
inflammation-induced_growth_of_thyroid_cancer
(Tumor growth process)
Original: Tumor-associated macrophages and NF-魏B activation#mediate#inflammation-induced growth and progression of thyroid cancer
#19165
middle Confidence
Subject:
NF-κB
(Transcription Factors)
→
mediates
→
Object:
inflammation-induced_growth_of_thyroid_cancer
(Tumor growth process)
Original: Tumor-associated macrophages and NF-魏B activation#mediate#inflammation-induced growth and progression of thyroid cancer
#19114
middle Confidence
Subject:
rRNA_synthesis_perturbation
(Molecular Process)
→
is_related_to
→
Object:
tumor_progression
(Tumor progression)
Original: Perturbations of rRNA synthesis#are related to#cell proliferation and tumor progression
#19113
middle Confidence
Subject:
rRNA_synthesis_perturbation
(Molecular Process)
→
is_related_to
→
Object:
cell_proliferation
(Cell proliferation)
Original: Perturbations of rRNA synthesis#are related to#cell proliferation and tumor progression
#19053
middle Confidence
Subject:
NCL_lactylation
(Protein modification)
→
promotes
→
Object:
proliferation_of_iCCA_cells
(Cellular Processes)
Original: Nucleolin lactylation#promotes#proliferation of iCCA cells
#17897
middle Confidence
Subject:
cytologic_specimens
(Cytology specimens)
→
show
→
Object:
invasive_squamous_cell_carcinoma
(Tumor type)
Original: Cytologic specimens#show#progression from mild atypia to marked atypia before invasive squamous cell carcinoma
#17896
middle Confidence
Subject:
cytologic_specimens
(Cytology specimens)
→
show
→
Object:
marked_atypia
(Cell phenotype)
Original: Cytologic specimens#show#progression from mild atypia to marked atypia before invasive squamous cell carcinoma
#17895
middle Confidence
Subject:
cytologic_specimens
(Cytology specimens)
→
show
→
Object:
progression_of_atypia
(Cell phenotype)
Original: Cytologic specimens#show#progression from mild atypia to marked atypia before invasive squamous cell carcinoma
#17465
middle Confidence
Subject:
DNA_aneuploidy
(Genomic abnormalities)
→
is_related_to
→
Object:
morphological_change_to_pleomorphic_cells
(Cell morphology changes)
Original: DNA aneuploidy#is related to#morphological change in transforming to bizarre pleomorphic cells
#17255
middle Confidence
Subject:
CAFs
(cancer-associated fibroblasts)
→
play_roles_in
→
Object:
lung_cancer_progression
(Tumor progression)
Original: CAFs#play roles in#lung cancer progression
#16645
middle Confidence
Subject:
mitotic_frequency
(Cell cycle indicators)
→
increases_in
→
Object:
untreated_prostatic_adenocarcinoma
(Malignant tumors)
Original: Mitotic frequency#increases in#untreated prostatic adenocarcinoma compared to non-neoplastic prostate
#14386
middle Confidence
Subject:
neoplastic_cells
(Tumor cells)
→
proliferate_in
→
Object:
organs
(organ)
Original: neoplastic cells#proliferate in#organs throughout the body
#13563
middle Confidence
Subject:
neoplastic_lymphocytes
(Neoplastic lymphocytes)
→
infiltrated
→
Object:
ciliary_epithelium
(Ciliary epithelium)
Original: neoplastic lymphocytes#infiltrated#ciliary epithelium and extended into pars plana and peripheral choroid
#12728
middle Confidence
Subject:
KRAS_signaling_pathway
(signaling pathway)
→
is_upregulated_in
→
Object:
high_CAF_infiltration
(Tumor microenvironment characteristics)
Original: pathways such as allograft rejection/ epithelial-mesenchymal transition/ KRAS signaling#were upregulated in#patients with high CAF infiltration
#12718
middle Confidence
Subject:
RPF2
(Ribosome-associated proteins)
→
promotes
→
Object:
cell_invasion
(Cell invasion)
Original: Overexpression of RPF2#promoted#cell proliferation/ migration/ and invasion
#12717
middle Confidence
Subject:
RPF2
(Ribosome-associated proteins)
→
promotes
→
Object:
cell_migration
(Cell migration)
Original: Overexpression of RPF2#promoted#cell proliferation/ migration/ and invasion
#12716
middle Confidence
Subject:
RPF2
(Ribosome-associated proteins)
→
promotes
→
Object:
cell_proliferation
(Cell proliferation)
Original: Overexpression of RPF2#promoted#cell proliferation/ migration/ and invasion
#12350
middle Confidence
Subject:
netrin-1
(Signaling protein)
→
stimulates
→
Object:
tumor_growth
(Tumor growth)
Original: N-netrin-1#stimulates#cell proliferation in vitro and tumor growth in vivo
#12349
middle Confidence
Subject:
netrin-1
(Signaling protein)
→
stimulates
→
Object:
cell_proliferation
(Cell proliferation)
Original: N-netrin-1#stimulates#cell proliferation in vitro and tumor growth in vivo
#12302
middle Confidence
Subject:
Metabolic rewiring
(Metabolic reprogramming process)
→
links_with
→
Object:
canonical oncogenic pathways
(signaling pathway)
Original: metabolic rewiring#links with#canonical oncogenic pathways
#12003
middle Confidence
Subject:
USP39
(protein)
→
affects
→
Object:
tumor_progression
(Tumor progression)
Original: USP39 depletion#affects#tumor progression
#8413
middle Confidence
Subject:
Tumor_cells
(Tumor cells)
→
exhibit
→
Object:
proliferation
(Cellular Processes)
Original: Loosely packed tumor cells#exhibit#extensive proliferation and elongation of cytoplasmic extensions (filopodia)
#3281
low Confidence
Subject:
neoplastic_lymphocytes
(Neoplastic lymphocytes)
→
extended_into
→
Object:
peripheral_choroid
(Eye anatomy)
Original: neoplastic lymphocytes#infiltrated#ciliary epithelium and extended into pars plana and peripheral choroid
#3280
low Confidence
Subject:
neoplastic_lymphocytes
(Neoplastic lymphocytes)
→
extended_into
→
Object:
pars_plana
(Eye anatomy)
Original: neoplastic lymphocytes#infiltrated#ciliary epithelium and extended into pars plana and peripheral choroid