临床相关性：Tumorigenesis
A total of 81 records found
#22240
high Confidence
Subject:
hepatic_flexure_colon_tumor
(Hepatic flexure colon tumor)
→
occurred_in
→
Object:
elderly_female_patient
(Elderly female patients)
Original: A hepatic flexure colon tumor#occurred in#a 61-year-old woman with no primary lung cancer lesion
#22109
high Confidence
Subject:
Breast cancer stem cells
(Cancer stem cells)
→
are_key_players_in
→
Object:
carcinogenesis
(Tumor development process)
Original: Breast cancer stem cells#are key players in#carcinogenesis and development
#21764
high Confidence
Subject:
malignant_tumor
(Tumor)
→
may_arise_from
→
Object:
ovarian_mature_cystic_teratoma
(Ovarian tumors)
Original: malignant tumors#may arise from#ovarian mature cystic teratoma
#21661
high Confidence
Subject:
CCND1
(Protein coding genes)
→
has_oncogenic_role_in
→
Object:
human_tumors
(Disease phenotype)
Original: Cyclin D1 gene#has#an oncogenic role in human tumors
#21647
high Confidence
Subject:
DEN_exposure
(Environmental carcinogens)
→
induces
→
Object:
neoplasms
(Tumor)
Original: DEN exposure#induces#altered foci and neoplasms in fish
#21646
high Confidence
Subject:
DEN_exposure
(Environmental carcinogens)
→
induces
→
Object:
altered_foci
(Pathological morphology)
Original: DEN exposure#induces#altered foci and neoplasms in fish
#21369
high Confidence
Subject:
IGCN
(Histopathological entities)
→
is_precursor_of
→
Object:
testicular_cancer
(disease)
Original: Intratubular germ cell neoplasia (IGCN)#is considered to be#a precursor of testicular cancer
#20575
high Confidence
Subject:
DNAJB1-PRKACA_fusion
(Fusion gene)
→
initiates
→
Object:
tumor_formation
(Tumor development process)
Original: Dnajb1-Prkaca fusion gene#initiates#tumor formation in wild-type mice
#20574
high Confidence
Subject:
DNAJB1
(Protein coding genes)
→
is_fused_with
→
Object:
PRKACA
(Protein coding genes)
Original: 400 Kb deletion on chromosome 19#fuses#DNAJB1 and PRKACA genes in FL-HCC patients
#20532
high Confidence
Subject:
hybrid_oncogene_of_thyrotropin_beta-subunit_and_SV40_large_T-antigen
(Chimeric oncogene)
→
induces
→
Object:
pituitary_tumorigenesis
(Tumor development process)
Original: Hybrid oncogene of thyrotropin beta-subunit and SV40 large T-antigen#induces#pituitary tumorigenesis in transgenic mice
#20448
high Confidence
Subject:
TP53
(Tumor suppressor genes)
→
is_involved_in
→
Object:
oncogenesis
(Tumorigenesis)
Original: GLTSCR2#is involved in#oncogenesis with p53/ NPM/ and MYC
#20418
high Confidence
Subject:
ECT2
(Guanine nucleotide exchange factor)
→
promotes
→
Object:
tumor_formation
(Tumor formation)
Original: ECT2#promotes#tumor formation
#20417
high Confidence
Subject:
ECT2
(Guanine nucleotide exchange factor)
→
promotes
→
Object:
tumorigenesis
(Tumorigenesis)
Original: ECT2#promotes#tumorigenesis
#20405
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
regulates
→
Object:
tumorigenesis
(Tumor development process)
Original: FBL#regulates#tumorigenesis and DNA damage response
#20355
high Confidence
Subject:
TP53
(Transcription Factors)
→
augments
→
Object:
ribosome_production
(Ribosome biogenesis)
Original: cancer genes#augment#ribosome production
#20354
high Confidence
Subject:
MYC
(Transcription Factors)
→
augments
→
Object:
ribosome_production
(Ribosome biogenesis)
Original: cancer genes#augment#ribosome production
#20093
high Confidence
Subject:
tumorigenesis
(Tumor development process)
→
is_linked_to
→
Object:
ribosome_biogenesis
(Cellular Processes)
Original: Tumorigenesis#is linked to#ribosome biogenesis
#20067
high Confidence
Subject:
Ribosome methylation profiles
(Molecular Modification Omics)
→
is_altered_in
→
Object:
cancer
(Disease phenotype)
Original: snoRNA expression and ribosome methylation profiles#are altered in#cancer
#20066
high Confidence
Subject:
snoRNA expression
(Noncoding RNA expression)
→
is_altered_in
→
Object:
cancer
(Disease phenotype)
Original: snoRNA expression and ribosome methylation profiles#are altered in#cancer
#19910
middle Confidence
Subject:
protein_succination
(Molecular modification)
→
drives
→
Object:
oncogenesis_of_kidney_tumors
(Tumor development process)
Original: Aberrant protein succination#drives#oncogenesis of kidney tumors in HLRCC
#19877
middle Confidence
Subject:
DDX31
(RNA helicase)
→
plays_critical_role_in
→
Object:
renal_carcinogenesis
(Tumor development process)
Original: DDX31#plays#critical roles in renal carcinogenesis
#19874
middle Confidence
Subject:
nucleolar_localization_disruption
(Abnormal subcellular localization)
→
propels
→
Object:
parathyroid_tumorigenesis
(Tumor development process)
Original: disruption of nucleolar localization#propels#parathyroid tumorigenesis
#19831
middle Confidence
Subject:
SNORA68
(Small nuclear RNA)
→
promotes
→
Object:
carcinogenesis
(Tumorigenesis)
Original: SNORA68#promotes#cell stemness and carcinogenesis in TNBC
#19830
middle Confidence
Subject:
SNORA68
(Small nuclear RNA)
→
promotes
→
Object:
cell_stemness
(Cell stemness)
Original: SNORA68#promotes#cell stemness and carcinogenesis in TNBC
#19630
middle Confidence
Subject:
giant_congenital_melanocytic_nevus
(Benign skin tumors)
→
transformed_into
→
Object:
malignant_melanoma
(Malignant tumors)
Original: giant congenital melanocytic nevus#transformed into#malignant melanoma
#19161
middle Confidence
Subject:
Dysregulated_rRNA_synthesis_by_Pol_I
(Transcription abnormalities)
→
is_associated_with
→
Object:
uncontrolled_cell_proliferation
(Cellular Processes)
Original: Dysregulated rRNA synthesis by Pol I#is associated with#uncontrolled cell proliferation
#18999
middle Confidence
Subject:
LINC_complex_component
(Protein complex subunit)
→
are_deficient_in
→
Object:
breast_cancer_tissue
(Tumor tissue)
Original: components of LINC complex#are deficient in#breast cancer tissues
#18972
middle Confidence
Subject:
p120
(protein)
→
induces
→
Object:
malignant_transformation
(Disease phenotype)
Original: transfection of p120 complementary DNA#caused#malignant transformation of NIH/3T3 cells
#18861
middle Confidence
Subject:
SNORA68
(Small nuclear RNA)
→
determines
→
Object:
carcinogenesis
(Tumorigenesis)
Original: SNORA68#determined#carcinogenesis and stemness maintenance
#18489
middle Confidence
Subject:
driver_genetic_aberrations
(Genetic variation)
→
enables
→
Object:
proliferation_of_melanocytes
(Cellular Processes)
Original: Driver genetic aberrations#enable#proliferation of melanocytes
#17590
middle Confidence
Subject:
uterine_cervix_preneoplasia
(Precancerous lesions)
→
progresses_towards
→
Object:
Neoplasia
(Tumor)
Original: uterine cervix preneoplasia#progresses towards#neoplasia
#17374
middle Confidence
Subject:
XIAP
(Inhibitor of apoptosis protein)
→
associated_with
→
Object:
defective_apoptotic_pathways
(signaling pathway)
Original: Increased expression of XIAP#from PA to cellular PA to CXPA#adds to understanding of defective apoptotic pathways
#17373
middle Confidence
Subject:
XIAP
(Inhibitor of apoptosis protein)
→
upregulated_in
→
Object:
carcinoma_ex_pleomorphic_adenoma
(Tumor cells)
Original: Increased expression of XIAP#from PA to cellular PA to CXPA#adds to understanding of defective apoptotic pathways
#17372
middle Confidence
Subject:
XIAP
(Inhibitor of apoptosis protein)
→
upregulated_in
→
Object:
cellular_pleomorphic_adenoma
(Tumor cells)
Original: Increased expression of XIAP#from PA to cellular PA to CXPA#adds to understanding of defective apoptotic pathways
#17283
middle Confidence
Subject:
tumor_suppressor_genes
(Tumor suppressor genes)
→
loss_of
→
Object:
development_of_prostatic_adenocarcinoma
(Tumor development process)
Original: loss of tumor suppressor genes and activation of oncogenes in breakpoint regions#may be important for#development or progression of prostatic adenocarcinoma
#17227
middle Confidence
Subject:
SPC25
(Protein coding genes)
→
promotes
→
Object:
cell_proliferation
(Cellular Processes)
Original: SPC25#encouraged#tumor cell proliferation and growth
#17214
middle Confidence
Subject:
p27BBP
(Ribosomal proteins)
→
shows_increased_nucleolar_component_in
→
Object:
dysplastic_adenomas
(Disease phenotype)
Original: p27BBP#displays#a large increase of its nucleolar component in dysplastic adenomas and carcinomas
#17210
middle Confidence
Subject:
Brachyury
(Transcription Factors)
→
induces
→
Object:
cancer_inducing_properties
(Oncogenic phenotype)
Original: Brachyury#is expressed in#a number of tumor types and has cancer-inducing properties
#17209
middle Confidence
Subject:
Brachyury
(Transcription Factors)
→
is_expressed_in
→
Object:
tumor
(Tumor)
Original: Brachyury#is expressed in#a number of tumor types and has cancer-inducing properties
#17122
middle Confidence
Subject:
CDKN1C
(protein)
→
allows
→
Object:
tumor_cell_bypass_of_BRAF_induced_senescence
(Escape from cellular senescence)
Original: Pro-oncogenic activities of CDKI (p27 and p57)#allow#tumor cells to bypass BRAF-induced senescence
#17121
middle Confidence
Subject:
CDKN1B
(protein)
→
allows
→
Object:
tumor_cell_bypass_of_BRAF_induced_senescence
(Escape from cellular senescence)
Original: Pro-oncogenic activities of CDKI (p27 and p57)#allow#tumor cells to bypass BRAF-induced senescence
#17107
middle Confidence
Subject:
FGF
(Growth factor protein)
→
is_involved_in
→
Object:
tumorigenesis
(Tumor development process)
Original: basic FGF#is involved in#tumorigenesis and malignant progression
#16946
middle Confidence
Subject:
UTP18
(Ribosome biogenesis protein)
→
promotes
→
Object:
tumorigenesis
(Tumorigenesis)
Original: UTP18 overexpression#promotes#transformation and tumorigenesis
#16945
middle Confidence
Subject:
UTP18
(Ribosome biogenesis protein)
→
promotes
→
Object:
cellular_transformation
(Cell transformation)
Original: UTP18 overexpression#promotes#transformation and tumorigenesis
#16944
middle Confidence
Subject:
netrin-1
(Signaling protein)
→
displays
→
Object:
proto-oncogenic_activity
(Oncogene activity)
Original: netrin-1#displays#proto-oncogenic activity in several cancers
#16915
middle Confidence
Subject:
PAX_transcription_factors
(Transcription factor family)
→
play_important_role_in
→
Object:
carcinogenesis
(Tumor development process)
Original: PAX transcription factors#play an important role in#development and carcinogenesis
#16889
middle Confidence
Subject:
ECT2
(Guanine nucleotide exchange factor)
→
promotes
→
Object:
transformed_cell_growth
(Transformed cell growth)
Original: ECT2#promotes#transformed cell growth
#16831
middle Confidence
Subject:
tumor_suppressors
(Tumor suppressor proteins)
→
interfere_with
→
Object:
rRNA_synthesis
(rRNA synthesis)
Original: Oncogenic proteins and tumor suppressors#target#RNA polymerase I and interfere with rRNA synthesis
#16830
middle Confidence
Subject:
oncogenic_proteins
(Oncogenic proteins)
→
interfere_with
→
Object:
rRNA_synthesis
(rRNA synthesis)
Original: Oncogenic proteins and tumor suppressors#target#RNA polymerase I and interfere with rRNA synthesis
#16829
middle Confidence
Subject:
tumor_suppressors
(Tumor suppressor proteins)
→
target
→
Object:
RNA_polymerase_I
(Transcriptase)
Original: Oncogenic proteins and tumor suppressors#target#RNA polymerase I and interfere with rRNA synthesis
#16828
middle Confidence
Subject:
oncogenic_proteins
(Oncogenic proteins)
→
target
→
Object:
RNA_polymerase_I
(Transcriptase)
Original: Oncogenic proteins and tumor suppressors#target#RNA polymerase I and interfere with rRNA synthesis
#16819
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
loss
→
Object:
Stabilization_of_c-Myc
(Protein stability)
Original: NPM1 loss#stabilizes#c-Myc
#16742
middle Confidence
Subject:
carcinogen_dosage
(Chemical Dosage)
→
affects
→
Object:
colonic_carcinogenesis
(Tumor development process)
Original: carcinogen dosage#affects#experimental colonic carcinogenesis
#16698
middle Confidence
Subject:
cancer_genes
(Protein coding genes)
→
induce
→
Object:
cellular_structural_changes
(Changes in cell structure)
Original: cancer genes#induce#cellular-level structural changes
#16517
middle Confidence
Subject:
neoplastic_cellular_proliferation
(Tumor cell proliferation)
→
_from
→
Object:
lining_of_cystic_structures
(Organizational Structure)
Original: neoplastic cellular proliferation#originated from#the lining of cystic structures
#15872
middle Confidence
Subject:
FeLV-positive_cats
(Animal models)
→
contain
→
Object:
CD3-immunoreactive_tumors
(Tumor diseases)
Original: FeLV-positive cats#contain#CD3-immunoreactive tumors
#15867
middle Confidence
Subject:
Kaposi_sarcoma
(Kaposi sarcoma)
→
undergoes
→
Object:
cellular_transformation
(Cell transformation)
Original: Kaposi's sarcoma#undergoes#cellular transformation from early to late stages
#15233
middle Confidence
Subject:
reserve_cell
(Reserve cells)
→
considered_as
→
Object:
cell_of_origin_for_cervical_adenocarcinoma
(Cellular origin)
Original: Findings#suggested#reserve cell as the cell of origin for cervical adenocarcinoma
#14874
middle Confidence
Subject:
PIA
(Pathological changes)
→
suggested_as
→
Object:
precursor_of_prostate_malignancy
(Precursor lesions)
Original: PIA#is suggested as#a candidate precursor of prostate malignancy
#12540
middle Confidence
Subject:
SV40_large_T_antigen
(Viral Protein)
→
is_expressed_in
→
Object:
nucleus_of_undifferentiated_cells
(Cellular substructure)
Original: SV40 large T antigen#is expressed in#nucleus of undifferentiated cells
#12437
middle Confidence
Subject:
NS1_overexpression
(Gene overexpression)
→
correlates_with
→
Object:
melanotic_tumors
(Tumor phenotype)
Original: Severe overexpression of NS1#correlates with#melanotic tumors and larval/pupal lethality
#12425
middle Confidence
Subject:
MYC
(Transcription Factors)
→
is_involved_in
→
Object:
oncogenesis
(Tumorigenesis)
Original: GLTSCR2#is involved in#oncogenesis with p53/ NPM/ and MYC
#12424
middle Confidence
Subject:
NPM1
(Nucleolar phosphatase)
→
is_involved_in
→
Object:
oncogenesis
(Tumorigenesis)
Original: GLTSCR2#is involved in#oncogenesis with p53/ NPM/ and MYC
#12423
middle Confidence
Subject:
GLTSCR2
(Tumor suppressor-related proteins)
→
is_involved_in
→
Object:
oncogenesis
(Tumorigenesis)
Original: GLTSCR2#is involved in#oncogenesis with p53/ NPM/ and MYC
#12315
middle Confidence
Subject:
p53
(Tumor suppressor proteins)
→
is_upregulated_in
→
Object:
ERG-overexpressing_prostatic_intraepithelial_neoplasia_mouse_models
(Disease Models)
Original: p53 expression#is higher in#ERG-overexpressing prostatic intraepithelial neoplasia mouse models
#12297
middle Confidence
Subject:
ECT2
(Guanine nucleotide exchange factor)
→
promotes
→
Object:
transformed_growth
(Cellular Processes)
Original: UBF1-mediated ECT2 recruitment#promotes#transformed growth
#12025
middle Confidence
Subject:
MARK4L_isoform
(protein)
→
is_candidate_for
→
Object:
role_in_neoplastic_transformation
(Tumor development process)
Original: MARK4L isoform#is a candidate for#a role in neoplastic transformation
#11977
middle Confidence
Subject:
RB1
(Cell cycle regulatory proteins)
→
augments
→
Object:
ribosome_production
(Ribosome biogenesis)
Original: cancer genes#augment#ribosome production
#11976
middle Confidence
Subject:
CDKN1B
(Cell cycle regulatory proteins)
→
augments
→
Object:
ribosome_production
(Ribosome biogenesis)
Original: cancer genes#augment#ribosome production
#11136
middle Confidence
Subject:
Prostatic_endocrine_cells
(Endocrine cells)
→
may_give_rise_to
→
Object:
carcinoid_tumors
(Carcinoid)
Original: Prostatic endocrine cells#may give rise to#carcinoid tumors
#8420
middle Confidence
Subject:
preneoplastic_epithelium
(Epithelial tissue)
→
exhibits
→
Object:
prominent_nucleoli_with_microsegregation
(Nuclear phenotype)
Original: Preneoplastic epithelium#exhibits#widened intercellular space/ increasing tonofilaments/ enlarged nuclei with deep indentations/ and prominent nucleoli with microsegregation
#8419
middle Confidence
Subject:
preneoplastic_epithelium
(Epithelial tissue)
→
exhibits
→
Object:
enlarged_nuclei_with_deep_indentations
(Nuclear phenotype)
Original: Preneoplastic epithelium#exhibits#widened intercellular space/ increasing tonofilaments/ enlarged nuclei with deep indentations/ and prominent nucleoli with microsegregation
#8418
middle Confidence
Subject:
preneoplastic_epithelium
(Epithelial tissue)
→
exhibits
→
Object:
increased_tonofilaments
(Cytoskeleton)
Original: Preneoplastic epithelium#exhibits#widened intercellular space/ increasing tonofilaments/ enlarged nuclei with deep indentations/ and prominent nucleoli with microsegregation
#8417
middle Confidence
Subject:
preneoplastic_epithelium
(Epithelial tissue)
→
exhibits
→
Object:
widened_intercellular_space
(Organizational Structure)
Original: Preneoplastic epithelium#exhibits#widened intercellular space/ increasing tonofilaments/ enlarged nuclei with deep indentations/ and prominent nucleoli with microsegregation
#6554
middle Confidence
Subject:
p27BBP
(Ribosomal protein binding protein)
→
is_early_event_in
→
Object:
transition_from_benign_to_malignant_colorectal_phenotypes
(Tumor development process)
Original: p27BBP alterations#are an early event in#transition from benign to malignant colorectal phenotypes
#6508
middle Confidence
Subject:
PICT-1
(Protein coding genes)
→
influences
→
Object:
tumorigenesis
(Tumor development process)
Original: PICT-1 localization#advances understanding of#its influence on cell fate and tumorigenesis
#6507
middle Confidence
Subject:
PICT-1
(Protein coding genes)
→
influences
→
Object:
cell_fate
(Cellular Processes)
Original: PICT-1 localization#advances understanding of#its influence on cell fate and tumorigenesis
#6379
middle Confidence
Subject:
Diploidisation
(Cell genetic changes)
→
may_provide
→
Object:
functional_advantage_for_expansion_of_preneoplastic_cells
(Cell expansion advantages)
Original: Diploidisation#may provide#a functional advantage for expansion of preneoplastic cells
#5894
middle Confidence
Subject:
chromosomal_abnormalities
(Chromosomal abnormalities)
→
are_associated_with
→
Object:
Neoplasia
(Tumorigenesis)
Original: Chromosomal abnormalities#are associated with#neoplasia
#3357
low Confidence
Subject:
epigenetic_changes
(Epigenetic modification)
→
may_have_contributed_to
→
Object:
malignant_NB_cells_development
(Tumor development process)
Original: Epigenetic changes#may have contributed to#development of malignant NB cells
#2364
low Confidence
Subject:
Colonies
(Cell colonies)
→
may_be_precursors_of
→
Object:
hepatocarcinoma
(Liver cancer)
Original: Colonies#may be#precursors of the hepatocarcinomas