临床相关性：Pathogenesis
A total of 42 records found
#22065
high Confidence
Subject:
2;17_translocation
(Chromosomal translocation)
→
results_in
→
Object:
CLTC-ALK_fusion
(Gene fusion)
Original: 2;17 translocation#resulted in#fusion of CLTC gene with ALK
#22048
high Confidence
Subject:
Epstein-Barr_virus_infection
(Viral infection)
→
is_strongly_associated_with
→
Object:
Nonkeratinizing_nasopharyngeal_carcinoma
(Malignant tumors)
Original: Nonkeratinizing NPC#is strongly associated with#prior Epstein-Barr virus (EBV) infection
#21867
high Confidence
Subject:
Epstein-Barr_virus
(Virus)
→
is_implicated_in
→
Object:
AIDS-related_primary_CNS_lymphoma
(disease)
Original: Epstein-Barr virus (EBV)#is implicated in#AIDS-related primary CNS lymphoma
#21836
high Confidence
Subject:
Ewing's_sarcoma
(Tumor type)
→
originates_from
→
Object:
neuroectodermal_cells
(Neuroectodermal cells)
Original: This aggressive and infrequent tumor#originates from#neuroectodermal cells
#21557
high Confidence
Subject:
ALK
(Tyrosine kinase)
→
is_activated_through
→
Object:
chromosomal_translocation_with_NPM
(Genomic abnormalities)
Original: ALK#is activated through#chromosomal translocations with NPM
#21507
high Confidence
Subject:
MAPK/ERK_pathway_mutations
(Signaling pathway mutations)
→
are_indicative_of
→
Object:
clonal_process
(Cellular Processes)
Original: MAPK/ERK pathway mutations#are indicative of#a clonal process
#21400
high Confidence
Subject:
Helicobacter_pylori_infection
(Infectious Agents)
→
affects
→
Object:
carcinoma
(Tumor)
Original: Helicobacter pylori infection#affects#gastric epithelia/ gastritis/ intestinal metaplasia/ and carcinoma
#21399
high Confidence
Subject:
Helicobacter_pylori_infection
(Infectious Agents)
→
affects
→
Object:
intestinal_metaplasia
(Pathological changes)
Original: Helicobacter pylori infection#affects#gastric epithelia/ gastritis/ intestinal metaplasia/ and carcinoma
#21398
high Confidence
Subject:
Helicobacter_pylori_infection
(Infectious Agents)
→
affects
→
Object:
gastritis
(disease)
Original: Helicobacter pylori infection#affects#gastric epithelia/ gastritis/ intestinal metaplasia/ and carcinoma
#21397
high Confidence
Subject:
Helicobacter_pylori_infection
(Infectious Agents)
→
affects
→
Object:
gastric_epithelia
(Organization Type)
Original: Helicobacter pylori infection#affects#gastric epithelia/ gastritis/ intestinal metaplasia/ and carcinoma
#21256
high Confidence
Subject:
VIN_usual_type
(Pathological type)
→
is_related_to
→
Object:
HPV_high_risk_type_infection
(Viral infection)
Original: VIN/ usual type#is related to#HPV high-risk type infection
#21097
high Confidence
Subject:
primary_oncocytic_carcinoma
(Tumor diseases)
→
occurs_in
→
Object:
salivary_glands
(Glandular tissue)
Original: Primary oncocytic carcinoma#occurs in#salivary glands
#20988
high Confidence
Subject:
meningiomas
(Tumor type)
→
are_derived_from
→
Object:
arachnoid_cells
(Cell Type)
Original: meningiomas#are derived from#arachnoid cells
#20956
high Confidence
Subject:
malignant_lymphoma
(Tumor type)
→
originates_in
→
Object:
bone
(organ)
Original: Malignant lymphoma#originates in#bone
#20945
high Confidence
Subject:
17_month_old_infant
(patient)
→
developed
→
Object:
acute_megakaryoblastic_leukemia
(disease)
Original: A 17-month-old infant#developed#acute megakaryoblastic leukemia
#20907
high Confidence
Subject:
MYCN amplification
(Gene amplification)
→
promotes
→
Object:
karyorrhectic activity
(Cellular Processes)
Original: MYCN amplification#promotes#mitotic and karyorrhectic activities
#20906
high Confidence
Subject:
MYCN amplification
(Gene amplification)
→
promotes
→
Object:
Mitotic activity
(Cellular Processes)
Original: MYCN amplification#promotes#mitotic and karyorrhectic activities
#20905
high Confidence
Subject:
MYCN amplification
(Gene amplification)
→
inhibits
→
Object:
cellular differentiation
(Cell differentiation)
Original: MYCN amplification#prevents#cellular differentiation
#20817
high Confidence
Subject:
Antibodies
(Antibody)
→
target
→
Object:
epithelial_cell_surface_glycoproteins
(Epithelial cell surface glycoprotein)
Original: Pemphigus vulgaris (PV)#is caused by#abnormal production of antibodies against epithelial cell surface glycoproteins
#20816
high Confidence
Subject:
Pemphigus_vulgaris
(disease)
→
is_caused_by
→
Object:
abnormal_production_of_antibodies
(Abnormal antibody production)
Original: Pemphigus vulgaris (PV)#is caused by#abnormal production of antibodies against epithelial cell surface glycoproteins
#20399
high Confidence
Subject:
NPM1
(Protein coding genes)
→
leads_to
→
Object:
aberrant_cytoplasmic_localization
(Subcellular localization)
Original: Mutations in NPM1#lead to#aberrant cytoplasmic localization in AML
#19520
middle Confidence
Subject:
human_ovarian_surface_epithelial_cells
(Cell Type)
→
are_putative_source_of
→
Object:
ovarian_epithelial_cancer
(Tumor)
Original: Human ovarian surface epithelium (HOSE)#is the putative source of#ovarian epithelial cancer
#19486
middle Confidence
Subject:
fibrolamellar_carcinoma
(Tumor type)
→
characterized_by
→
Object:
activation_of_protein_kinase_A
(Signaling pathway activation)
Original: fibrolamellar carcinomas#are characterized by#activation of protein kinase A
#19286
middle Confidence
Subject:
Ewing_sarcoma
(Tumor type)
→
affects
→
Object:
head_and_neck_region
(Anatomical Region)
Original: Ewing sarcoma#arises from#long bones and affects the head and neck region in 1%-4% cases
#19285
middle Confidence
Subject:
Ewing_sarcoma
(Tumor type)
→
arises_from
→
Object:
long_bones
(Bone tissue)
Original: Ewing sarcoma#arises from#long bones and affects the head and neck region in 1%-4% cases
#18785
middle Confidence
Subject:
centroacinar_cell
(Cell Type)
→
is_proposed_as
→
Object:
origin_of_SPT
(Origin of tumorigenesis)
Original: centroacinar cell#is proposed as#the origin of SPT
#18784
middle Confidence
Subject:
tumor_cells
(Tumor cells)
→
suggests
→
Object:
centroacinar_cell_origin
(Cell Type)
Original: tumor cells#suggest#a centroacinar cell origin
#18008
middle Confidence
Subject:
lymphomatoid_papulosis
(Tumor type)
→
associated_with
→
Object:
HIV_infection
(Infectious Diseases)
Original: lymphomatoid papulosis#is associated with#HIV infection
#18000
middle Confidence
Subject:
fibrolamellar_carcinoma
(Fibrolamellar carcinoma of the liver)
→
arises_in
→
Object:
noncirrhotic_livers
(liver)
Original: fibrolamellar carcinoma#arises in#noncirrhotic livers of young individuals
#17554
middle Confidence
Subject:
Melanocytes
(Melanocytes)
→
proliferate_over
→
Object:
temporal_bulbar_conjunctiva
(Conjunctiva temporal bulbar conjunctiva)
Original: Melanocytes#proliferate over#the temporal bulbar conjunctiva
#17345
middle Confidence
Subject:
immunohistochemical_findings
(Immunohistochemical findings)
→
support
→
Object:
neural_crest_origin
(Origin of the organization)
Original: ultrastructural and immunohistochemical findings#supported#neural crest origin of this tumor
#17344
middle Confidence
Subject:
ultrastructural_findings
(Ultrastructural findings)
→
support
→
Object:
neural_crest_origin
(Origin of the organization)
Original: ultrastructural and immunohistochemical findings#supported#neural crest origin of this tumor
#14906
middle Confidence
Subject:
Schneiderian_epithelium
(Epithelial tissue)
→
can_give_rise_to
→
Object:
sinonasal_carcinoma
(Tumor diseases)
Original: Schneiderian epithelium#can give rise to#sinonasal carcinomas
#14586
middle Confidence
Subject:
Ewing's_sarcoma
(Tumor)
→
arises_from
→
Object:
neuroectodermal_cells
(Cell Type)
Original: This aggressive and infrequent tumor#usually develops in#the long bones of pediatric and young adult patients
#13424
middle Confidence
Subject:
primary_acquired_melanosis_without_atypia
(disease)
→
is_created_by
→
Object:
increased_melanocytes_in_basilar_region
(Changes in cell biology)
Original: Primary acquired melanosis without atypia#is created by#increased melanocytes restricted to the basilar region
#13423
middle Confidence
Subject:
primary_acquired_melanosis
(disease)
→
is
→
Object:
proliferative_condition_of_melanocytes
(Cell Biology Process)
Original: Primary acquired melanosis (PAM)#is#predominantly a proliferative condition of melanocytes
#12979
middle Confidence
Subject:
tumor_cells
(Tumor cells)
→
supported
→
Object:
Sertoli_cell_origin
(Cellular origin)
Original: tumor cells#supported#a Sertoli cell origin
#12188
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
mutation
→
Object:
tryptophan_disruption
(Abnormal protein structure)
Original: NPM1 mutations#create#a nuclear export signal and disrupt tryptophans
#12187
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
mutation
→
Object:
nuclear_export_signal_creation
(Signal Generation)
Original: NPM1 mutations#create#a nuclear export signal and disrupt tryptophans
#10690
middle Confidence
Subject:
ARF_null_keratinocytes
(Cell Model)
→
were_transformed_by
→
Object:
oncogenic_ras
(protein)
Original: ARF-null keratinocytes#were transformed by#oncogenic ras
#10517
middle Confidence
Subject:
Gastric pyloric gland adenomas
(Tumor type)
→
arise_in
→
Object:
Chronically damaged mucosa
(Pathological conditions)
Original: Gastric pyloric gland adenomas#arise in#chronically damaged mucosa
#1088
low Confidence
Subject:
tumor
(Tumor diseases)
→
may_arise_in
→
Object:
bone
(Organ/Tissue)
Original: tumors#may arise in#various locations in bone