临床相关性：Response to treatment
A total of 52 records found
#22127
high Confidence
Subject:
5_fluorouracil
(Small molecule drugs)
→
activates
→
Object:
p53
(Transcription Factors)
Original: 5-fluorouracil#activates#p53 by inducing ribosomal stress
#20531
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
decreases
→
Object:
melanoma_cell_size
(Cell phenotype)
Original: GSK2118436 treatment#decreased#melanoma cell size
#20530
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN1C_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20529
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN1B_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20528
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN1A_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20527
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN2A_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20274
high Confidence
Subject:
imatinib_mesylate
(Targeted drugs)
→
induces
→
Object:
partial_response_with_tumor_size_reduction
(Response to treatment)
Original: Neoadjuvant imatinib mesylate treatment#revealed#a partial response with tumor size reduction
#19717
middle Confidence
Subject:
slow_tumor_cell_proliferation
(Tumor cells proliferate slowly)
→
contributes_to
→
Object:
decrease_in_tumor_size_during_CTVT_regression
(CTVT tumor volume reduction)
Original: slow tumor cell proliferation#contributes to#decrease in tumor size during CTVT regression
#18885
middle Confidence
Subject:
PCNA
(Proliferation-related proteins)
→
reveals
→
Object:
decreased_proliferative_activity
(Cell proliferation activity)
Original: PCNA#revealed#decreased proliferative activity in treated prostatic carcinoma
#18884
middle Confidence
Subject:
NADT
(Treatment options)
→
decreases
→
Object:
serum_PSA
(Serum markers)
Original: NADT#decreased#prostate volume/ tumor volume/ and serum PSA
#18883
middle Confidence
Subject:
NADT
(Treatment options)
→
decreases
→
Object:
tumor_volume
(Tumor volume)
Original: NADT#decreased#prostate volume/ tumor volume/ and serum PSA
#18882
middle Confidence
Subject:
NADT
(Treatment options)
→
decreases
→
Object:
prostate_volume
(Organ volume)
Original: NADT#decreased#prostate volume/ tumor volume/ and serum PSA
#18881
middle Confidence
Subject:
NADT
(Treatment options)
→
was_evaluated_by
→
Object:
cellular_proliferation_indices
(Cell proliferation markers)
Original: Effectiveness of NADT#was evaluated by#prostate volume/ tumor volume/ serum PSA/ staging/ and cellular proliferation indices
#18880
middle Confidence
Subject:
NADT
(Treatment options)
→
was_evaluated_by
→
Object:
staging
(Disease Stage)
Original: Effectiveness of NADT#was evaluated by#prostate volume/ tumor volume/ serum PSA/ staging/ and cellular proliferation indices
#18879
middle Confidence
Subject:
NADT
(Treatment options)
→
was_evaluated_by
→
Object:
serum_PSA
(Serum markers)
Original: Effectiveness of NADT#was evaluated by#prostate volume/ tumor volume/ serum PSA/ staging/ and cellular proliferation indices
#18878
middle Confidence
Subject:
NADT
(Treatment options)
→
was_evaluated_by
→
Object:
tumor_volume
(Tumor volume)
Original: Effectiveness of NADT#was evaluated by#prostate volume/ tumor volume/ serum PSA/ staging/ and cellular proliferation indices
#18877
middle Confidence
Subject:
NADT
(Treatment options)
→
was_evaluated_by
→
Object:
prostate_volume
(Organ volume)
Original: Effectiveness of NADT#was evaluated by#prostate volume/ tumor volume/ serum PSA/ staging/ and cellular proliferation indices
#18752
middle Confidence
Subject:
patient
(patient)
→
achieved
→
Object:
clinical_remission
(Disease remission)
Original: The patient#achieved#clinical remission for 1(1/2) years after 2 separate chemotherapy regimens
#18112
middle Confidence
Subject:
rhabdoid phenotype in gastrointestinal neoplasms
(Tumor subtype)
→
is_associated_with
→
Object:
Unresponsiveness to therapy
(Drug resistance)
Original: rhabdoid phenotype in gastrointestinal neoplasms#is associated with#poor prognosis and unresponsiveness to therapy
#17809
middle Confidence
Subject:
cancer_nests
(Tumor cell structure)
→
exhibited
→
Object:
severely_damaged_cancer_cells
(Cell injury phenotype)
Original: Cancer nests#exhibited#severely damaged cancer cells at 1800 cGy or greater
#17553
middle Confidence
Subject:
chemotherapy
(Chemotherapy drugs)
→
induces
→
Object:
transient_improvement_of_skin_lesions
(Clinical symptoms)
Original: disease#demonstrated#aggressive course with transient improvement of skin lesions after chemotherapy
#17278
middle Confidence
Subject:
molecular_remission
(Disease remission)
→
is_attained_after
→
Object:
induction_therapy
(Therapeutic interventions)
Original: Hematological and molecular remission#is attained after#induction therapy
#17277
middle Confidence
Subject:
hematological_remission
(Disease remission)
→
is_attained_after
→
Object:
induction_therapy
(Therapeutic interventions)
Original: Hematological and molecular remission#is attained after#induction therapy
#16553
middle Confidence
Subject:
first_fraction_of_radiotherapy
(Treatment Process)
→
induces_changes_in
→
Object:
AgNORs
(Molecular modification)
Original: First fraction of radiotherapy protocol#induces changes in#silver-stained nucleolar organizer regions (AgNORs)
#16484
middle Confidence
Subject:
corticosteroids
(Therapeutic interventions)
→
induced
→
Object:
transient_remission
(Disease process)
Original: case 1#had#transient remission following radiation and corticosteroid therapy
#16483
middle Confidence
Subject:
radiation_therapy
(Therapeutic interventions)
→
induced
→
Object:
transient_remission
(Disease process)
Original: case 1#had#transient remission following radiation and corticosteroid therapy
#15259
middle Confidence
Subject:
serum NSE level
(Protein markers)
→
serves_as
→
Object:
index of chemotherapeutic effectiveness
(Treatment response indicators)
Original: increased serum NSE levels#may serve as#an index of chemotherapeutic effectiveness
#14890
middle Confidence
Subject:
decrease_in_tumor_size
(Disease phenotype)
→
is_associated_with
→
Object:
decline_in_serum_NSE_level
(Protein molecules)
Original: Chemotherapy-induced decrease in tumor size#is associated with#a decline in serum neuron-specific enolase (NSE) level
#14889
middle Confidence
Subject:
chemotherapy
(Treatment)
→
induces
→
Object:
decrease_in_tumor_size
(Disease phenotype)
Original: Chemotherapy-induced decrease in tumor size#is associated with#a decline in serum neuron-specific enolase (NSE) level
#13640
middle Confidence
Subject:
right_breast_mass
(Tumor)
→
is_significantly_smaller_than
→
Object:
before_treatment
(Status before treatment)
Original: right breast mass#is significantly smaller than#before
#13447
middle Confidence
Subject:
residual_carcinoma
(Tumor type)
→
shows
→
Object:
Mitoses
(Cell division)
Original: Residual carcinoma#showed#squamous cell metaplasia/ necrosis/ necrobiosis/ vacuolization/ rare nucleoli/ crystalloids/ high Gleason score/ lower capsular penetration/ necrosis/ and mitoses
#13446
middle Confidence
Subject:
residual_carcinoma
(Tumor type)
→
shows
→
Object:
Necrosis
(Cell Death)
Original: Residual carcinoma#showed#squamous cell metaplasia/ necrosis/ necrobiosis/ vacuolization/ rare nucleoli/ crystalloids/ high Gleason score/ lower capsular penetration/ necrosis/ and mitoses
#13445
middle Confidence
Subject:
residual_carcinoma
(Tumor type)
→
shows
→
Object:
squamous_cell_metaplasia
(Cell differentiation)
Original: Residual carcinoma#showed#squamous cell metaplasia/ necrosis/ necrobiosis/ vacuolization/ rare nucleoli/ crystalloids/ high Gleason score/ lower capsular penetration/ necrosis/ and mitoses
#13444
middle Confidence
Subject:
nonmalignant_prostatic_tissue
(Organization Type)
→
shows
→
Object:
high_grade_prostatic_intraepithelial_neoplasia
(Pathological characteristics)
Original: Nonmalignant prostatic tissue#showed#atrophy of prostatic acini/ fibrosis/ basal cell hyperplasia/ degenerative changes/ and decreased HGPIN
#13443
middle Confidence
Subject:
nonmalignant_prostatic_tissue
(Organization Type)
→
shows
→
Object:
degenerative_changes
(Cell damage)
Original: Nonmalignant prostatic tissue#showed#atrophy of prostatic acini/ fibrosis/ basal cell hyperplasia/ degenerative changes/ and decreased HGPIN
#13442
middle Confidence
Subject:
nonmalignant_prostatic_tissue
(Organization Type)
→
shows
→
Object:
basal_cell_hyperplasia
(Cell proliferation)
Original: Nonmalignant prostatic tissue#showed#atrophy of prostatic acini/ fibrosis/ basal cell hyperplasia/ degenerative changes/ and decreased HGPIN
#13441
middle Confidence
Subject:
nonmalignant_prostatic_tissue
(Organization Type)
→
shows
→
Object:
fibrosis
(Histological changes)
Original: Nonmalignant prostatic tissue#showed#atrophy of prostatic acini/ fibrosis/ basal cell hyperplasia/ degenerative changes/ and decreased HGPIN
#13440
middle Confidence
Subject:
nonmalignant_prostatic_tissue
(Organization Type)
→
shows
→
Object:
atrophy_of_prostatic_acini
(Histological changes)
Original: Nonmalignant prostatic tissue#showed#atrophy of prostatic acini/ fibrosis/ basal cell hyperplasia/ degenerative changes/ and decreased HGPIN
#12037
middle Confidence
Subject:
5-fluorouracil
(Chemotherapy drugs)
→
induce
→
Object:
changes_in_nuclear_AgNORs_pattern
(Nucleolus-related structural changes)
Original: RNA inhibitors and 5-fluorouracil#induce#changes in nuclear AgNORs pattern in human breast cancer cells
#12026
middle Confidence
Subject:
Adriamycin
(Chemotherapy drugs)
→
induces
→
Object:
JNK_activation
(Kinase activation)
Original: Administration of Adriamycin#induces#reversible activation of JNK in neuronal stress model
#11729
middle Confidence
Subject:
first_fraction_of_radiotherapy
(Treatment Process)
→
induces_changes_in
→
Object:
gynecologic_cancer
(Tumor type)
Original: First fraction of radiotherapy protocol#induces changes in#silver-stained nucleolar organizer regions (AgNORs)
#10593
middle Confidence
Subject:
immunofluorescence_signal
(Immunofluorescence signal)
→
was_diminished_for
→
Object:
protein_C23_in_lymphocytes_of_chemotherapy-treated_patients
(Protein expression status)
Original: Immunofluorescence#was diminished for#protein B23 and C23 in lymphocytes of chemotherapy-treated patients
#10592
middle Confidence
Subject:
immunofluorescence_signal
(Immunofluorescence signal)
→
was_diminished_for
→
Object:
protein_B23_in_lymphocytes_of_chemotherapy-treated_patients
(Protein expression status)
Original: Immunofluorescence#was diminished for#protein B23 and C23 in lymphocytes of chemotherapy-treated patients
#9954
middle Confidence
Subject:
Patient
(patient)
→
responds_to
→
Object:
pharmacological_treatment
(Drug treatment)
Original: Patient#responds to#pharmacological treatment
#9064
middle Confidence
Subject:
ulcer
(Disease phenotype)
→
did_not_heal
→
Object:
treatment_longer_than_6_months
(Treatment duration)
Original: Ulcer#did not heal#despite treatment for longer than 6 months
#8777
middle Confidence
Subject:
PEI
(Therapeutic interventions)
→
reduces
→
Object:
Cellularity
(Cell density)
Original: PEI#reduces#cellularity in 13 cases
#6313
middle Confidence
Subject:
Histone_deacetylase_inhibitors
(Epigenetic inhibitors)
→
affect
→
Object:
nucleolus
(Nucleolus)
Original: Histone deacetylase inhibitors#affect#nucleus and nucleolus of leukemic myeloblasts
#6312
middle Confidence
Subject:
Histone_deacetylase_inhibitors
(Epigenetic inhibitors)
→
affect
→
Object:
nucleus
(Nucleus)
Original: Histone deacetylase inhibitors#affect#nucleus and nucleolus of leukemic myeloblasts
#6311
middle Confidence
Subject:
RNA_inhibitors
(Small molecule inhibitors)
→
induce
→
Object:
changes_in_nuclear_AgNORs_pattern
(Nucleolus-related structural changes)
Original: RNA inhibitors and 5-fluorouracil#induce#changes in nuclear AgNORs pattern in human breast cancer cells
#5779
middle Confidence
Subject:
Atrophic_gastritis
(Chronic gastric disease)
→
remained_as
→
Object:
sole_lesion_after_BMMSC_infusion
(Pathological status after treatment)
Original: Atrophic gastritis#remained#as the sole lesion after BMMSCs infusion
#2654
low Confidence
Subject:
Patients_with_hormonal_therapy
(patient)
→
are_alive_after
→
Object:
hormonal_therapy
(Therapeutic interventions)
Original: Seven of 12 patients#are alive after#radiation or hormonal therapy
#2653
low Confidence
Subject:
Patients_with_radiation_therapy
(patient)
→
are_alive_after
→
Object:
radiation_therapy
(Therapeutic interventions)
Original: Seven of 12 patients#are alive after#radiation or hormonal therapy