List of serched triples

A total of 22252 records found

#16792 middle Confidence
Subject: inhibition_of_PARylation_of_DDX21 (Protein modification)
→ mislocalizes →
Object: DDX21_to_nucleoplasm (Protein subcellular localization)
Original: Inhibition of PARP1-mediated ADPRylation of DDX21 by niraparib#mislocalizes#DDX21 to nucleoplasm
🏥 Treatment Mechanism 🧬 DDX21 📄 PMID: 38767454
Details
#16791 middle Confidence
Subject: loss_of_NPM_nucleolar_localization (Abnormal subcellular localization)
→ leads_to →
Object: loss_of_functions_in_DNA-damage_repair (Molecular Process)
Original: Loss of NPM nucleolar localization#leads to#a loss of functions in ribosome biogenesis or DNA-damage repair
🏥 not_specified 🧬 NPM1 📄 PMID: 30130654
Details
#16790 middle Confidence
Subject: loss_of_NPM_nucleolar_localization (Abnormal subcellular localization)
→ leads_to →
Object: loss_of_functions_in_ribosome_biogenesis (Molecular Process)
Original: Loss of NPM nucleolar localization#leads to#a loss of functions in ribosome biogenesis or DNA-damage repair
🏥 not_specified 🧬 NPM1 📄 PMID: 30130654
Details
#16789 middle Confidence
Subject: p53 (Tumor suppressor proteins)
→ contributes_to →
Object: S9_induced_apoptosis (Apoptosis)
Original: p53#contributes to#S9-induced apoptosis
🏥 not_specified 🧬 TP53 📄 PMID: 36071402
Details
#16788 middle Confidence
Subject: MDM2 (Ubiquitin ligase)
→ is_required_for →
Object: S9_induced_apoptosis (Apoptosis)
Original: MDM2#is required for#S9-induced G2 cell cycle arrest and apoptosis
🏥 not_specified 🧬 MDM2 📄 PMID: 36071402
Details
#16787 middle Confidence
Subject: MDM2 (Ubiquitin ligase)
→ is_required_for →
Object: S9_induced_G2_cell_cycle_arrest (Cell cycle arrest)
Original: MDM2#is required for#S9-induced G2 cell cycle arrest and apoptosis
🏥 not_specified 🧬 MDM2 📄 PMID: 36071402
Details
#16786 middle Confidence
Subject: S9 (Small molecule drugs)
→ inhibits →
Object: cancer_cell_proliferation (Cellular Processes)
Original: S9#inhibits#cancer cell proliferation in vitro and in vivo
🏥 treat 📄 PMID: 36071402
Details
#16785 middle Confidence
Subject: TNF (Cytokines)
→ downregulated_in →
Object: HIE_PD-MSC_treatment_group (Treatment Group)
Original: HIE + PD-MSC treatment groups#showed#lower expression levels of BAX/ BAD/ IL-1β/ TNF-α
🏥 not_specified 🧬 BAX/BAD/IL1B/TNF 📄 PMID: 38682178
Details
#16784 middle Confidence
Subject: IL1B (Cytokines)
→ downregulated_in →
Object: HIE_PD-MSC_treatment_group (Treatment Group)
Original: HIE + PD-MSC treatment groups#showed#lower expression levels of BAX/ BAD/ IL-1β/ TNF-α
🏥 not_specified 🧬 BAX/BAD/IL1B/TNF 📄 PMID: 38682178
Details
#16783 middle Confidence
Subject: BAD (Apoptosis regulatory proteins)
→ downregulated_in →
Object: HIE_PD-MSC_treatment_group (Treatment Group)
Original: HIE + PD-MSC treatment groups#showed#lower expression levels of BAX/ BAD/ IL-1β/ TNF-α
🏥 not_specified 🧬 BAX/BAD/IL1B/TNF 📄 PMID: 38682178
Details
#16782 middle Confidence
Subject: BAX (Apoptosis regulatory proteins)
→ downregulated_in →
Object: HIE_PD-MSC_treatment_group (Treatment Group)
Original: HIE + PD-MSC treatment groups#showed#lower expression levels of BAX/ BAD/ IL-1β/ TNF-α
🏥 not_specified 🧬 BAX/BAD/IL1B/TNF 📄 PMID: 38682178
Details
#16781 middle Confidence
Subject: TGFB1 (Cytokines)
→ upregulated_in →
Object: HIE_PD-MSC_treatment_group (Treatment Group)
Original: HIE + PD-MSC treatment groups#showed#higher expression levels of MAP-2/ BCL-2/ IL-10/ TGF-β1
🏥 not_specified 🧬 MAP2/BCL2/IL10/TGFB1 📄 PMID: 38682178
Details
#16780 middle Confidence
Subject: IL10 (Cytokines)
→ upregulated_in →
Object: HIE_PD-MSC_treatment_group (Treatment Group)
Original: HIE + PD-MSC treatment groups#showed#higher expression levels of MAP-2/ BCL-2/ IL-10/ TGF-β1
🏥 not_specified 🧬 MAP2/BCL2/IL10/TGFB1 📄 PMID: 38682178
Details
#16779 middle Confidence
Subject: BCL2 (Apoptosis regulatory proteins)
→ upregulated_in →
Object: HIE_PD-MSC_treatment_group (Treatment Group)
Original: HIE + PD-MSC treatment groups#showed#higher expression levels of MAP-2/ BCL-2/ IL-10/ TGF-β1
🏥 not_specified 🧬 MAP2/BCL2/IL10/TGFB1 📄 PMID: 38682178
Details
#16778 middle Confidence
Subject: MAP2 (Microtubule-associated protein)
→ upregulated_in →
Object: HIE_PD-MSC_treatment_group (Treatment Group)
Original: HIE + PD-MSC treatment groups#showed#higher expression levels of MAP-2/ BCL-2/ IL-10/ TGF-β1
🏥 not_specified 🧬 MAP2/BCL2/IL10/TGFB1 📄 PMID: 38682178
Details
#16777 middle Confidence
Subject: PD-MSC_transplantation (Cell therapy)
→ enhances →
Object: muscle_strength (Motor function phenotype)
Original: PD-MSC transplantation#enhances#motor coordination and muscle strength in HIE rats
🏥 treat 📄 PMID: 38682178
Details
#16776 middle Confidence
Subject: PD-MSC_transplantation (Cell therapy)
→ enhances →
Object: motor_coordination (Motor function phenotype)
Original: PD-MSC transplantation#enhances#motor coordination and muscle strength in HIE rats
🏥 treat 📄 PMID: 38682178
Details
#16775 middle Confidence
Subject: PARP1_cleavage (Protein modification)
→ precedents →
Object: DNA_fragmentation_by_TUNEL (DNA damage markers)
Original: PARP-1 cleavage#precedes#DNA fragmentation detected by TUNEL assay
🏥 not_specified 🧬 PARP1 📄 PMID: 12845642
Details
#16774 middle Confidence
Subject: Trichostatin_A (Small molecule inhibitors)
→ has_cytostatic_effects →
Object: cytostatic_effects (Cell growth inhibition)
Original: TSA#is a#histone deacetylase inhibitor with cytostatic effects
🏥 Therapeutic significance 📄 PMID: 18840553
Details
#16773 middle Confidence
Subject: Trichostatin_A (Small molecule inhibitors)
→ affects →
Object: nucleolar_size (Cell structure characteristics)
Original: Trichostatin A (TSA)#affects#nucleolar density and size in apoptotic human leukemic myeloblasts
🏥 not_specified 📄 PMID: 18840553
Details