临床相关性：Treatment Mechanism
A total of 14 records found
#21568
high Confidence
Subject:
Niraparib
(PARP inhibitors)
→
inhibits
→
Object:
PARP1-mediated_ADPRylation_of_DDX21
(Protein modification)
Original: Inhibition of PARP1-mediated ADPRylation of DDX21 by niraparib#mislocalizes#DDX21 to nucleoplasm
#21567
high Confidence
Subject:
CX5461
(Small molecule inhibitors)
→
targets
→
Object:
RNAPOL1
(RNA polymerase)
Original: CX5461#disrupts#nucleolar integrity by targeting RNAPOL1
#21553
high Confidence
Subject:
DHODH
(Enzymes)
→
inhibition_depletes
→
Object:
pyrimidine_pool
(Metabolites)
Original: Pharmacological inhibition of DHODH#depleted#the pool of pyrimidines in glioblastoma cells
#21427
high Confidence
Subject:
Bortezomib
(Proteasome inhibitors)
→
interferes_with
→
Object:
protein_biosynthesis_at_nucleolar_ribosome_biogenesis_stage
(Molecular Process)
Original: bortezomib#interferes with#protein biosynthesis at nucleolar ribosome biogenesis stage
#20380
high Confidence
Subject:
RNA_Polymerase_I_inhibitor
(Small molecule inhibitors)
→
blocks
→
Object:
ribosomal_DNA_transcription
(Transcription process)
Original: Small molecule inhibitors of RNA Polymerase I#block#ribosomal DNA transcription
#20379
high Confidence
Subject:
CX5461
(Small molecule inhibitors)
→
disrupts
→
Object:
nucleolar_integrity
(Subcellular structure)
Original: CX5461#disrupts#nucleolar integrity by targeting RNAPOL1
#20361
high Confidence
Subject:
DHODH
(Enzymes)
→
inhibition_impairs
→
Object:
rDNA_transcription
(Transcription process)
Original: DHODH inhibition#impaired#rDNA transcription/ leading to nucleolar stress
#20360
high Confidence
Subject:
Actinomycin_D
(Chemotherapy drugs)
→
induces
→
Object:
reorganization_of_nucleolar_components
(Subcellular structural changes)
Original: Actinomycin D (AMD)#induces#reorganization of nucleolar components by inhibiting rRNA synthesis
#18637
middle Confidence
Subject:
Dopamine_agonist
(drug)
→
affects
→
Object:
hormone_release
(Molecular Process)
Original: Dopamine agonist#affects#hormone synthesis/ release/ and degradation in PRL-secreting adenoma cells
#18636
middle Confidence
Subject:
Dopamine_agonist
(drug)
→
affects
→
Object:
hormone_synthesis
(Molecular Process)
Original: Dopamine agonist#affects#hormone synthesis/ release/ and degradation in PRL-secreting adenoma cells
#16792
middle Confidence
Subject:
inhibition_of_PARylation_of_DDX21
(Protein modification)
→
mislocalizes
→
Object:
DDX21_to_nucleoplasm
(Protein subcellular localization)
Original: Inhibition of PARP1-mediated ADPRylation of DDX21 by niraparib#mislocalizes#DDX21 to nucleoplasm
#15987
middle Confidence
Subject:
Dopamine_agonist
(drug)
→
affects
→
Object:
hormone_degradation
(Molecular Process)
Original: Dopamine agonist#affects#hormone synthesis/ release/ and degradation in PRL-secreting adenoma cells
#4940
middle Confidence
Subject:
Treatment
(Therapeutic interventions)
→
reduces
→
Object:
granule_size
(Cellular substructure)
Original: Treatment#reduces#volume density of rough ER and granule size
#4939
middle Confidence
Subject:
Treatment
(Therapeutic interventions)
→
reduces
→
Object:
volume_density_of_rough_ER
(Cellular substructure)
Original: Treatment#reduces#volume density of rough ER and granule size