临床相关性：Therapeutic significance
A total of 167 records found
#21856
high Confidence
Subject:
postoperative_radiotherapy
(Postoperative radiotherapy)
→
is_used_as_adjuvant_treatment_for
→
Object:
oncocytic_carcinoma
(Tumor diseases)
Original: Postoperative radiotherapy#is used as#adjuvant treatment for oncocytic carcinoma
#21855
high Confidence
Subject:
surgery
(Surgery)
→
is_principal_treatment_for
→
Object:
oncocytic_carcinoma
(Tumor diseases)
Original: Surgery#is#the principal treatment for oncocytic carcinoma
#21704
high Confidence
Subject:
radiotherapy
(Radiation therapy)
→
treats
→
Object:
lymphoma
(disease)
Original: Patient#was given#radiotherapy 33 times after the biopsy
#21673
high Confidence
Subject:
radiation
(Treatment)
→
markedly_reduce
→
Object:
tumor_size
(Tumor phenotype)
Original: Steroids and radiation#markedly reduce#tumor size
#21672
high Confidence
Subject:
steroids
(drug)
→
markedly_reduce
→
Object:
tumor_size
(Tumor phenotype)
Original: Steroids and radiation#markedly reduce#tumor size
#21644
high Confidence
Subject:
mTOR_pathway_proteins
(Signaling pathway proteins)
→
are_activated_in
→
Object:
ductal_adenocarcinoma
(Tumor type)
Original: mTOR pathway proteins#are activated in#ductal adenocarcinoma
#21610
high Confidence
Subject:
p53
(Transcription Factors)
→
leads_to
→
Object:
apoptosis
(Apoptosis)
Original: Accumulation of p53#leads to#cell cycle arrest or apoptosis
#21609
high Confidence
Subject:
p53
(Transcription Factors)
→
leads_to
→
Object:
cell_cycle_arrest
(Cell cycle arrest)
Original: Accumulation of p53#leads to#cell cycle arrest or apoptosis
#21552
high Confidence
Subject:
DDX21_knockdown
(Genetic intervention)
→
reduces
→
Object:
tumorigenicity
(Tumorigenicity)
Original: DDX21 knockdown#reduces#tumorigenicity in vitro and in vivo
#21551
high Confidence
Subject:
DDX21_knockdown
(Genetic intervention)
→
induces
→
Object:
apoptosis_in_tumor_cells
(Cellular Processes)
Original: DDX21 knockdown#induces#apoptosis in tumor cells
#21549
high Confidence
Subject:
Bleomycin
(Anticancer drugs)
→
inhibits
→
Object:
DNA_synthesis
(Molecular Process)
Original: Bleomycin#inhibits#DNA synthesis
#21535
high Confidence
Subject:
NCL
(Nucleolin)
→
is_promising_target_for
→
Object:
treatment_of_gastric_cancer
(Clinical treatment)
Original: nucleolin on cell surface#is a promising target for#treatment of gastric cancer
#21465
high Confidence
Subject:
podophyllin
(Anticancer drugs)
→
treats
→
Object:
condylomata_acuminata
(Virus-related diseases)
Original: Some changes#have been described in#condylomata acuminata treated with topical applications of podophyllin
#21424
high Confidence
Subject:
mTOR_pathway
(signaling pathway)
→
plays_critical_role_in
→
Object:
FLC
(Tumor type)
Original: mTOR pathway activation#plays#a critical role in 47% of FLC tumors
#21340
high Confidence
Subject:
chemotherapy
(Chemotherapy regimen)
→
achieved
→
Object:
complete_remission
(Response to treatment)
Original: Six cases#achieved#complete remission after chemotherapy
#21339
high Confidence
Subject:
R-CHOP
(Chemotherapy regimen)
→
was_administered_to
→
Object:
patients_with_Pulmonary_intravascular_large_B_cell_lymphoma
(patient)
Original: Seven patients#received#R-CHOP-based chemotherapy
#20601
high Confidence
Subject:
apocrine_breast_carcinoma
(Breast cancer)
→
shows
→
Object:
ERBB2_expression
(Protein expression)
Original: Apocrine breast carcinomas#show#abundant GCDFP-15/ CEA/ and c-erbB-2 oncoprotein
#20537
high Confidence
Subject:
tumor_immune_microenvironment
(Tissue Microenvironment)
→
performs
→
Object:
treatment_effectiveness
(Response to treatment)
Original: Tumor immune microenvironment (TME)#performs#a critical function in the prediction of clinical outcomes and treatment effectiveness
#20520
high Confidence
Subject:
MYB
(Protein coding genes)
→
high_expression_suggests
→
Object:
targeted_therapy_for_ACC
(Treatment options)
Original: High expression of MYB transcription factors#suggests#targeted approaches for ACC therapy
#20460
high Confidence
Subject:
ALLN
(Proteasome inhibitors)
→
inhibits
→
Object:
Survivin-deltaEx3_degradation
(Protein degradation process)
Original: Proteasome inhibitors MG132 or ALLN#inhibit#degradation of Survivin-deltaEx3
#20459
high Confidence
Subject:
MG132
(Proteasome inhibitors)
→
inhibits
→
Object:
Survivin-deltaEx3_degradation
(Protein degradation process)
Original: Proteasome inhibitors MG132 or ALLN#inhibit#degradation of Survivin-deltaEx3
#20432
high Confidence
Subject:
Oxaliplatin
(Chemotherapy drugs)
→
inhibits
→
Object:
rRNA_synthesis_by_POLR1
(Transcription process)
Original: Oxaliplatin#significantly inhibits#rRNA synthesis by Pol I
#20371
high Confidence
Subject:
Deguelin
(Small molecule drugs)
→
is
→
Object:
anti_tumor_agent
(Anticancer drugs)
Original: Deguelin#is shown to be#a strong anti-tumor agent
#20366
high Confidence
Subject:
actinomycin_D
(Small molecule drugs)
→
inhibits
→
Object:
RNA_Polymerase_I
(Enzymes)
Original: Pharmacologic inhibition of RNA polymerase I#attenuates#signal in prostate tissue slices
#20365
high Confidence
Subject:
BMH-21
(Small molecule drugs)
→
inhibits
→
Object:
RNA_Polymerase_I
(Enzymes)
Original: Pharmacologic inhibition of RNA polymerase I#attenuates#signal in prostate tissue slices
#20146
high Confidence
Subject:
liver_transplantation
(Organ transplantation treatment)
→
treats
→
Object:
liver_disease_patient
(patient)
Original: liver transplantation#is an effective treatment for#patients with many kinds of liver diseases
#20095
high Confidence
Subject:
5-azacytidine
(DNA methylation inhibitors)
→
inhibits
→
Object:
rRNA_processing
(Ribosomal RNA processing)
Original: 5-azacytidine#inhibits#rRNA processing
#20043
high Confidence
Subject:
Patients
(patient)
→
were_treated_with
→
Object:
DXT
(Radiation therapy)
Original: Patients#suffered from#oral squamous cell carcinoma and were treated with surgery and DXT
#20042
high Confidence
Subject:
Patients
(patient)
→
were_treated_with
→
Object:
surgery
(Surgery)
Original: Patients#suffered from#oral squamous cell carcinoma and were treated with surgery and DXT
#19917
middle Confidence
Subject:
UBA2_knockdown
(Genetic intervention)
→
suppresses
→
Object:
glioma_cell_progression
(Tumor progression)
Original: UBA2 knockdown#suppresses#glioma cell progression
#19868
middle Confidence
Subject:
Silvestrol
(Small molecule drugs)
→
promotes
→
Object:
apoptosis_in_cancer_cells
(Cellular Processes)
Original: Silvestrol#promotes#apoptosis in cancer cells more than in normal cells
#19862
middle Confidence
Subject:
aneuploid_carcinoma
(Aneuploid cancer)
→
responds_better_to
→
Object:
chemotherapy
(Chemotherapy)
Original: Aneuploid carcinomas#respond better to#chemotherapy
#19808
middle Confidence
Subject:
tumor_resection
(Surgery)
→
results_in
→
Object:
no_recurrence
(Disease Prognosis)
Original: Biopsy/ chemotherapy/ and tumor resection#resulted in#no recurrence
#19807
middle Confidence
Subject:
biopsy
(Diagnostic techniques)
→
results_in
→
Object:
no_recurrence
(Disease Prognosis)
Original: Biopsy/ chemotherapy/ and tumor resection#resulted in#no recurrence
#19806
middle Confidence
Subject:
chemotherapy
(Chemotherapy drugs)
→
results_in
→
Object:
no_recurrence
(Disease Prognosis)
Original: Biopsy/ chemotherapy/ and tumor resection#resulted in#no recurrence
#19778
middle Confidence
Subject:
Autologous_PD-MSC_therapy
(Cell therapy)
→
could_have_potential_application_for
→
Object:
treatment_of_HIE
(Disease treatment)
Original: Autologous PD-MSC therapy#could have#potential application for treatment of HIE
#19758
middle Confidence
Subject:
MADD
(Protein coding genes)
→
activates
→
Object:
ERK_signaling
(signaling pathway)
Original: MADD#activates#ERK signaling
#19711
middle Confidence
Subject:
curcumin
(Natural product drugs)
→
downregulates
→
Object:
proliferative_activity
(Cell proliferation activity)
Original: The effects of low concentrations of curcumin#were studied on#human cervical cancer cells
#19564
middle Confidence
Subject:
excision
(Clinical operation)
→
offers
→
Object:
potential_cure_for_melanoma
(Treatment Outcomes)
Original: Early detection and excision#offer#a potential cure for melanoma
#19563
middle Confidence
Subject:
early_detection
(Clinical operation)
→
offers
→
Object:
potential_cure_for_melanoma
(Treatment Outcomes)
Original: Early detection and excision#offer#a potential cure for melanoma
#19560
middle Confidence
Subject:
chemotherapy
(Chemotherapy drugs)
→
induces
→
Object:
regeneration_of_destroyed_skull_bone
(Bone regeneration)
Original: chemotherapy#induced#regeneration of destroyed skull bone
#19558
middle Confidence
Subject:
palliative_radiotherapy_DT_40Gy/20F
(Radiation therapy options)
→
was_provided_for
→
Object:
metastatic_foci_in_T1-T7
(Tumor metastasis)
Original: palliative radiotherapy DT 40Gy/20F#was provided for#metastatic foci in sternum and T1-T7
#19557
middle Confidence
Subject:
palliative_radiotherapy_DT_40Gy/20F
(Radiation therapy options)
→
was_provided_for
→
Object:
metastatic_foci_in_sternum
(Tumor metastasis)
Original: palliative radiotherapy DT 40Gy/20F#was provided for#metastatic foci in sternum and T1-T7
#19450
middle Confidence
Subject:
Localized_radiotherapy
(Treatment)
→
treats
→
Object:
lesion
(Lesions)
Original: Lesions#were successfully treated with#localized radiotherapy
#19293
middle Confidence
Subject:
cases
(Case)
→
showed
→
Object:
excellent_response_to_chemotherapy
(Response to treatment)
Original: cases#showed#excellent responses to chemotherapy
#19215
middle Confidence
Subject:
ALA-based_photodynamic_treatment
(Photodynamic therapy)
→
induces
→
Object:
chromatin_condensation
(Chromatin changes)
Original: ALA-based photodynamic treatment#produces#apoptotic bodies and chromatin condensation in cells
#19214
middle Confidence
Subject:
ALA-based_photodynamic_treatment
(Photodynamic therapy)
→
induces
→
Object:
apoptotic_bodies
(Cellular process products)
Original: ALA-based photodynamic treatment#produces#apoptotic bodies and chromatin condensation in cells
#19189
middle Confidence
Subject:
PRIMA-1
(Small molecule drugs)
→
induces
→
Object:
apoptosis
(Cellular Processes)
Original: PRIMA-1#induces#apoptosis
#19188
middle Confidence
Subject:
PRIMA-1
(Small molecule drugs)
→
restores
→
Object:
transcriptional_transactivation_function_of_mutant_p53
(Transcriptional regulation function)
Original: PRIMA-1#restores#transcriptional transactivation function to mutant p53
#19185
middle Confidence
Subject:
gamma-linolenic_acid
(fatty acid)
→
inhibits
→
Object:
cell_proliferation
(Cellular Processes)
Original: Gamma-linolenic acid (GLA)#inhibited#cell proliferation in MG-63 and HeLa cells
#19180
middle Confidence
Subject:
UBA2_knockdown
(Genetic intervention)
→
sensitizes
→
Object:
glioma_cells_to_irradiation
(Tumor cell sensitivity to radiotherapy)
Original: UBA2 knockdown#sensitizes#glioma cells to irradiation
#19173
middle Confidence
Subject:
PSAT1
(Phosphoserine aminotransferase)
→
suppresses
→
Object:
cell_invasion
(Cellular Processes)
Original: Knockdown of PSAT1#suppressed#cell proliferation/ migration/ and invasion of NSCLC
#19172
middle Confidence
Subject:
PSAT1
(Phosphoserine aminotransferase)
→
suppresses
→
Object:
cell_migration
(Cellular Processes)
Original: Knockdown of PSAT1#suppressed#cell proliferation/ migration/ and invasion of NSCLC
#19171
middle Confidence
Subject:
PSAT1
(Phosphoserine aminotransferase)
→
suppresses
→
Object:
cell_proliferation
(Cellular Processes)
Original: Knockdown of PSAT1#suppressed#cell proliferation/ migration/ and invasion of NSCLC
#19170
middle Confidence
Subject:
MCM6
(DNA replication-related enzymes)
→
inhibits
→
Object:
cell_invasion
(Cellular Processes)
Original: Silencing MCM6#inhibited#proliferation/ migration/ and invasive behavior of cancerous cells
#19169
middle Confidence
Subject:
MCM6
(DNA replication-related enzymes)
→
inhibits
→
Object:
cell_migration
(Cellular Processes)
Original: Silencing MCM6#inhibited#proliferation/ migration/ and invasive behavior of cancerous cells
#19168
middle Confidence
Subject:
MCM6
(DNA replication-related enzymes)
→
inhibits
→
Object:
cell_proliferation
(Cellular Processes)
Original: Silencing MCM6#inhibited#proliferation/ migration/ and invasive behavior of cancerous cells
#19167
middle Confidence
Subject:
LINE-1-encoded_RT
(Reverse transcriptase)
→
emerges_as
→
Object:
potential_therapeutic_target
(Therapeutic targets)
Original: LINE-1-encoded RT#emerges as#a potential therapeutic target for a large spectrum of cancers
#19150
middle Confidence
Subject:
PES1
(Ribosome biogenesis-associated protein)
→
regulates
→
Object:
NB_cell_proliferation
(Cell proliferation)
Original: PES1#regulates#NB cell proliferation
#19149
middle Confidence
Subject:
PES1
(Ribosome biogenesis-associated protein)
→
knockdown_induced
→
Object:
apoptosis
(Apoptosis)
Original: PES1 knockdown#induced#apoptosis
#19148
middle Confidence
Subject:
PES1
(Ribosome biogenesis-associated protein)
→
knockdown_suppressed
→
Object:
tumor_cell_growth
(Tumor cell proliferation)
Original: PES1 knockdown#suppressed#tumor cell growth
#19093
middle Confidence
Subject:
Hernandonine
(Small molecule compounds)
→
induces
→
Object:
cellular_apoptosis
(Apoptosis)
Original: Hernandonine#induces#cellular apoptosis in solid tumor cell lines
#19003
middle Confidence
Subject:
Trichostatin_A
(Small molecule inhibitors)
→
is_a
→
Object:
histone_deacetylase_inhibitor
(Enzyme inhibitors)
Original: TSA#is a#histone deacetylase inhibitor with cytostatic effects
#18971
middle Confidence
Subject:
hesperidin
(Small molecule drugs)
→
modifies
→
Object:
oesophageal_carcinogenesis
(Tumor development process)
Original: flavonoids diosmin and hesperidin#modify#oesophageal carcinogenesis during initiation and post-initiation phases
#18970
middle Confidence
Subject:
diosmin
(Small molecule drugs)
→
modifies
→
Object:
oesophageal_carcinogenesis
(Tumor development process)
Original: flavonoids diosmin and hesperidin#modify#oesophageal carcinogenesis during initiation and post-initiation phases
#18953
middle Confidence
Subject:
Sng
(Small molecule drugs)
→
shows_cytotoxicity_against
→
Object:
tumor_cells
(Tumor cells)
Original: Cytotoxicity of Sng#is well-established against#various tumor cells
#18952
middle Confidence
Subject:
Silvestrol
(Small molecule drugs)
→
shows_antitumor_activity_in
→
Object:
Liver cancer
(Tumor diseases)
Original: Silvestrol#has shown#promising antitumor activity in breast cancer/ melanoma/ liver cancer/ and other tumor types
#18951
middle Confidence
Subject:
Silvestrol
(Small molecule drugs)
→
shows_antitumor_activity_in
→
Object:
Melanoma
(Tumor diseases)
Original: Silvestrol#has shown#promising antitumor activity in breast cancer/ melanoma/ liver cancer/ and other tumor types
#18950
middle Confidence
Subject:
Silvestrol
(Small molecule drugs)
→
shows_antitumor_activity_in
→
Object:
Breast cancer
(Tumor diseases)
Original: Silvestrol#has shown#promising antitumor activity in breast cancer/ melanoma/ liver cancer/ and other tumor types
#18949
middle Confidence
Subject:
Bone marrow-derived mesenchymal stem cells
(Stem Cells)
→
inhibit
→
Object:
progression_of_gastric_precancerous_lesions
(Pathological process)
Original: Intravenous transplantation of BMMSCs#inhibited#the progression of precancerous gastric lesions
#18908
middle Confidence
Subject:
histopathological_criteria
(Histopathological criteria)
→
predict
→
Object:
response_to_cisplatinum_chemotherapy
(Response to cisplatin chemotherapy)
Original: Histopathological criteria#predict#response to cisplatinum chemotherapy
#18903
middle Confidence
Subject:
Green_tea
(Natural Products)
→
significantly_reduced
→
Object:
ras-p21_expression
(Protein expression)
Original: Green tea#significantly reduced#ras-p21 expression
#18902
middle Confidence
Subject:
Green_tea
(Natural Products)
→
significantly_reduced
→
Object:
proliferating_cell_nuclear_antigen_labeling_index
(Cell proliferation markers)
Original: Green tea#significantly reduced#proliferating cell nuclear antigen labeling index
#18693
middle Confidence
Subject:
Okadaic_acid
(Chemical inhibitors)
→
induces
→
Object:
apoptosis
(Apoptosis)
Original: Okadaic acid#induced#apoptosis in HSG and SCC-25 cells
#18692
middle Confidence
Subject:
Okadaic_acid
(Chemical inhibitors)
→
induces
→
Object:
apoptosis
(Apoptosis)
Original: Okadaic acid#induced#apoptosis in HSG and SCC-25 cells
#18678
middle Confidence
Subject:
exogenous_MK
(Exogenous cytokines)
→
protects
→
Object:
HepG2_cells_from_apoptosis
(cell)
Original: Exogenous MK#protects#HepG2 cells from apoptosis
#18676
middle Confidence
Subject:
nucleolus
(Cellular substructure)
→
is_targeted_by
→
Object:
therapies
(Therapeutic interventions)
Original: Therapies targeting nucleoli#are being developed for#emerging roles in DNA repair
#18654
middle Confidence
Subject:
hesperidin
(Small molecule drugs)
→
inhibits
→
Object:
development_of_oesophageal_cancer
(Tumor development process)
Original: diosmin and hesperidin supplementation#inhibits#development of oesophageal cancer
#18653
middle Confidence
Subject:
diosmin
(Small molecule drugs)
→
inhibits
→
Object:
development_of_oesophageal_cancer
(Tumor development process)
Original: diosmin and hesperidin supplementation#inhibits#development of oesophageal cancer
#18623
middle Confidence
Subject:
Sng
(Small molecule compounds)
→
induces
→
Object:
apoptosis
(Apoptosis)
Original: Sng#induces#apoptosis in cSCC cells
#18395
middle Confidence
Subject:
postoperative_radiation
(Radiation therapy)
→
was_given_as
→
Object:
50_Gy
(dose)
Original: Postoperative radiation#was given as#50 Gy/ resulting in disease-free status for 6 years
#18117
middle Confidence
Subject:
oncocytic_carcinoma_of_salivary_gland
(Tumor diseases)
→
is_studied_for
→
Object:
treatment
(treat)
Original: Oncocytic carcinoma of salivary gland#is studied for#clinicopathological features/ diagnosis/ treatment/ and prognosis
#18020
middle Confidence
Subject:
oral_etoposide
(Chemotherapy drugs)
→
has_beneficial_effect_on
→
Object:
skin_rash
(Skin symptoms)
Original: Low-dose oral etoposide#had#beneficial effect on skin rash
#17178
middle Confidence
Subject:
mutant_p53_redistribution_to_nucleoli
(Protein subcellular localization events)
→
plays_a_role_in
→
Object:
PRIMA-1_induced_apoptosis
(Apoptotic events)
Original: Redistribution of mutant p53 to nucleoli#plays a role in#PRIMA-1-induced apoptosis
#17164
middle Confidence
Subject:
chemotherapeutic_drugs
(drug)
→
affect
→
Object:
ribosome_biogenesis
(Molecular Process)
Original: Chemotherapeutic drugs#induce#nucleolar stress by affecting ribosome biogenesis in nucleolus
#17163
middle Confidence
Subject:
chemotherapeutic_drugs
(drug)
→
induce
→
Object:
nucleolar_stress
(Cellular stress)
Original: Chemotherapeutic drugs#induce#nucleolar stress by affecting ribosome biogenesis in nucleolus
#17134
middle Confidence
Subject:
RT
(Reverse transcriptase)
→
promotes
→
Object:
differentiation_of_cancer_cells
(Cellular Processes)
Original: RT inhibition#reduces#proliferation and promotes differentiation of cancer cells in murine models
#17133
middle Confidence
Subject:
RT
(Reverse transcriptase)
→
reduces
→
Object:
proliferation
(Cellular Processes)
Original: RT inhibition#reduces#proliferation and promotes differentiation of cancer cells in murine models
#17104
middle Confidence
Subject:
(-)-Epigallocatechin_gallate_(EGCG)
(Small molecule compounds)
→
exhibits
→
Object:
anti-cancer_activity
(Anticancer activity)
Original: (-)-Epigallocatechin gallate (EGCG)#exhibits#anti-cancer activity
#16972
middle Confidence
Subject:
Fisetin
(Natural small molecule compounds)
→
negatively_impacts
→
Object:
tumor_progression_signaling_pathways
(signaling pathway)
Original: Fisetin#negatively impacts#signaling pathways supporting tumor progression
#16879
middle Confidence
Subject:
CID-765471
(Small molecule compounds)
→
inhibits
→
Object:
ribosomal_DNA_transcription
(Molecular modification regulation)
Original: CID-765471#produces#nucleolar disruption by inhibiting ribosomal DNA transcription
#16878
middle Confidence
Subject:
CID-765471
(Small molecule compounds)
→
activates
→
Object:
p53
(Transcription Factors)
Original: CID-765471#activates#p53 independently of DNA damage
#16877
middle Confidence
Subject:
HB-19
(Synthetic small molecule drugs)
→
reduces
→
Object:
blood_vessel_branching
(Angiogenesis)
Original: HB-19#reduces#blood vessel branching in the chick embryo chorioallantoic membrane
#16876
middle Confidence
Subject:
HB-19
(Synthetic small molecule drugs)
→
inhibits
→
Object:
colony_formation
(Cell Biology Process)
Original: HB-19#inhibits#colony formation in tumor cell lines
#16774
middle Confidence
Subject:
Trichostatin_A
(Small molecule inhibitors)
→
has_cytostatic_effects
→
Object:
cytostatic_effects
(Cell growth inhibition)
Original: TSA#is a#histone deacetylase inhibitor with cytostatic effects
#16697
middle Confidence
Subject:
EMP3
(Membrane Protein)
→
downregulation_alleviates
→
Object:
lipid_storage
(Cellular metabolic process)
Original: Depletion of EMP3#alleviated#proliferation/ migration/ invasion/ and lipid storage in ccRCC cells
#16696
middle Confidence
Subject:
EMP3
(Membrane Protein)
→
downregulation_alleviates
→
Object:
cell_invasion
(Cellular Processes)
Original: Depletion of EMP3#alleviated#proliferation/ migration/ invasion/ and lipid storage in ccRCC cells
#16695
middle Confidence
Subject:
EMP3
(Membrane Protein)
→
downregulation_alleviates
→
Object:
cell_migration
(Cellular Processes)
Original: Depletion of EMP3#alleviated#proliferation/ migration/ invasion/ and lipid storage in ccRCC cells
#16694
middle Confidence
Subject:
EMP3
(Membrane Protein)
→
downregulation_alleviates
→
Object:
cell_proliferation
(Cellular Processes)
Original: Depletion of EMP3#alleviated#proliferation/ migration/ invasion/ and lipid storage in ccRCC cells
#16639
middle Confidence
Subject:
Picroliv
(Natural Medicine)
→
reduces
→
Object:
AgNOR_clusters
(Silver-stained clusters in the nucleolar organizer region)
Original: Picroliv treatment#reduces#elevated AgNOR dots and clusters in DMH-treated rat liver
#16638
middle Confidence
Subject:
Picroliv
(Natural Medicine)
→
reduces
→
Object:
AgNOR_dots
(Silver staining of nucleolar organizing region)
Original: Picroliv treatment#reduces#elevated AgNOR dots and clusters in DMH-treated rat liver
#16616
middle Confidence
Subject:
chemrad
(Combined chemoradiotherapy regimen)
→
is_used_as
→
Object:
neoadjuvant_treatment
(Neoadjuvant therapy)
Original: chemrad#is used as#neoadjuvant treatment for esophageal adenocarcinoma or squamous cell carcinoma
#16615
middle Confidence
Subject:
chemrad
(Combined chemoradiotherapy regimen)
→
is_used_as
→
Object:
neoadjuvant_treatment
(Neoadjuvant therapy)
Original: chemrad#is used as#neoadjuvant treatment for esophageal adenocarcinoma or squamous cell carcinoma
#16193
middle Confidence
Subject:
molecular_genetic_characteristics
(Molecular genetic characteristics)
→
provides
→
Object:
therapeutic_targets
(Therapeutic targets)
Original: combination of histological morphology/ immunophenotype/ and molecular genetic characteristics#provides#therapeutic targets for NTRK-RSCNs
#16192
middle Confidence
Subject:
immunophenotype
(Immunophenotype)
→
provides
→
Object:
therapeutic_targets
(Therapeutic targets)
Original: combination of histological morphology/ immunophenotype/ and molecular genetic characteristics#provides#therapeutic targets for NTRK-RSCNs
#16191
middle Confidence
Subject:
histological_morphology
(Histological characteristics)
→
provides
→
Object:
therapeutic_targets
(Therapeutic targets)
Original: combination of histological morphology/ immunophenotype/ and molecular genetic characteristics#provides#therapeutic targets for NTRK-RSCNs
#15951
middle Confidence
Subject:
NAC
(Small molecule antioxidants)
→
inhibits
→
Object:
ROS_production
(Reactive oxygen generation)
Original: NAC#inhibits#ROS production
#15641
middle Confidence
Subject:
patient
(patient)
→
was_treated_with
→
Object:
complete_surgical_excision
(Treatment)
Original: patient#was treated with#complete surgical excision without recurrence
#15565
middle Confidence
Subject:
PI3KCB
(Protein coding genes)
→
may_be_exploited_as
→
Object:
potential_therapeutic_target
(Potential therapeutic targets)
Original: Metabolic pathway-related genes#may be exploited as#potential targets for diagnosis and treatment
#15563
middle Confidence
Subject:
PIK3R5
(Protein coding genes)
→
may_be_exploited_as
→
Object:
potential_therapeutic_target
(Potential therapeutic targets)
Original: Metabolic pathway-related genes#may be exploited as#potential targets for diagnosis and treatment
#14891
middle Confidence
Subject:
MYC_amplification
(Gene amplification)
→
represented
→
Object:
therapeutically_targetable_oncogenic_pathway
(Therapeutically targetable pathways)
Original: MYC amplification#may represent#a therapeutically targetable oncogenic pathway in CIC-DUX sarcomas
#14581
middle Confidence
Subject:
She
(Patient characteristics)
→
underwent
→
Object:
endonasal_resection
(Surgery)
Original: She#underwent#endonasal resection
#12558
middle Confidence
Subject:
Liraglutide
(drug)
→
inhibits
→
Object:
proliferation
(Cellular Processes)
Original: Liraglutide#inhibits#lung cancer cell proliferation in vitro and in vivo
#12557
middle Confidence
Subject:
Liraglutide
(drug)
→
inhibits
→
Object:
migration
(Cellular Processes)
Original: Liraglutide#inhibits#proliferation/ cell cycle/ and migration of lung cancer cells
#12556
middle Confidence
Subject:
Liraglutide
(drug)
→
inhibits
→
Object:
cell_cycle
(Cellular Processes)
Original: Liraglutide#inhibits#proliferation/ cell cycle/ and migration of lung cancer cells
#12555
middle Confidence
Subject:
Liraglutide
(drug)
→
inhibits
→
Object:
proliferation
(Cellular Processes)
Original: Liraglutide#inhibits#proliferation/ cell cycle/ and migration of lung cancer cells
#12470
middle Confidence
Subject:
anticancer_agents
(Anticancer drugs)
→
cause
→
Object:
cytotoxicity
(Cytotoxicity)
Original: These two agents#cause#cytotoxicity
#12469
middle Confidence
Subject:
enzyme_inhibitors
(Enzyme inhibitors)
→
have_potential_as
→
Object:
anti_neoplastic_agents
(Anticancer drugs)
Original: Inhibitors of this enzyme#have potential as#anti-neoplastic agents
#12310
middle Confidence
Subject:
AG1478
(Small molecule inhibitors)
→
affects
→
Object:
tumor_cell_lines
(Tumor cell lines)
Original: EGFR kinase inhibitor AG1478#affects#tumor cell lines
#11986
middle Confidence
Subject:
Polyinosinate
(Synthetic oligonucleotides)
→
inhibits
→
Object:
tumor_rRNA_methylases
(Methyltransferase)
Original: Polyinosinate#inhibits#tumor ribosomal RNA methylases in vitro
#11967
middle Confidence
Subject:
TMEM17_silencing
(Gene silencing)
→
induces
→
Object:
apoptosis
(Apoptosis)
Original: Silencing TMEM17 in GBM cell lines#induced#apoptosis
#11966
middle Confidence
Subject:
TMEM17_silencing
(Gene silencing)
→
inhibits
→
Object:
invasion
(Cell invasion)
Original: Silencing TMEM17 in GBM cell lines#inhibited#proliferation and invasion
#11965
middle Confidence
Subject:
TMEM17_silencing
(Gene silencing)
→
inhibits
→
Object:
proliferation
(Cell proliferation)
Original: Silencing TMEM17 in GBM cell lines#inhibited#proliferation and invasion
#11962
middle Confidence
Subject:
BZW2
(Protein coding genes)
→
is_correlated_with
→
Object:
immunotherapy_response
(Immunotherapy response)
Original: BZW2#is correlated with#immunological characteristics/ tumor stemness/ drug sensitivity/ and immunotherapy response
#11961
middle Confidence
Subject:
BZW2
(Protein coding genes)
→
is_correlated_with
→
Object:
drug_sensitivity
(Drug sensitivity)
Original: BZW2#is correlated with#immunological characteristics/ tumor stemness/ drug sensitivity/ and immunotherapy response
#11939
middle Confidence
Subject:
isoflavone_mixture
(Plant Compound Blend)
→
inhibits
→
Object:
adenocarcinoma_cell_proliferation
(Adenocarcinoma cell proliferation)
Original: isoflavone mixture#inhibits#number of argyrophilic nucleolar organizer regions (AgNORs) in adenocarcinomas of the accessory sex glands
#11938
middle Confidence
Subject:
isoflavone_mixture
(Plant Compound Blend)
→
inhibits
→
Object:
AgNORs_number
(NOR)
Original: isoflavone mixture#inhibits#number of argyrophilic nucleolar organizer regions (AgNORs) in adenocarcinomas of the accessory sex glands
#11799
middle Confidence
Subject:
Green_tea
(Natural Products)
→
significantly_reduced
→
Object:
silver-stained_nucleolar_organizer_regions
(Nucleolar structural markers)
Original: Green tea#significantly reduced#silver-stained nucleolar organizer regions
#11635
middle Confidence
Subject:
KYN-54
(Small molecule compounds)
→
inhibits
→
Object:
oral_carcinogenesis
(Tumorigenesis)
Original: KYN-54#inhibits#oral carcinogenesis
#11500
middle Confidence
Subject:
Sng
(Small molecule compounds)
→
activates
→
Object:
JNK_signaling
(signaling pathway)
Original: Sng#induces#apoptosis in cSCC cells
#11474
middle Confidence
Subject:
LH-RH_antagonist
(Hormonal drugs)
→
decreases
→
Object:
AgNOR_number_in_tumor
(Molecular markers)
Original: LH-RH agonist and antagonist#decreased#number of Ag-NORs in tumors
#11473
middle Confidence
Subject:
LH-RH_agonist
(Hormonal drugs)
→
decreases
→
Object:
AgNOR_number_in_tumor
(Molecular markers)
Original: LH-RH agonist and antagonist#decreased#number of Ag-NORs in tumors
#11444
middle Confidence
Subject:
PLCG2
(Protein coding genes)
→
may_be_exploited_as
→
Object:
potential_therapeutic_target
(Potential therapeutic targets)
Original: Metabolic pathway-related genes#may be exploited as#potential targets for diagnosis and treatment
#11442
middle Confidence
Subject:
PLCB4
(Protein coding genes)
→
may_be_exploited_as
→
Object:
potential_therapeutic_target
(Potential therapeutic targets)
Original: Metabolic pathway-related genes#may be exploited as#potential targets for diagnosis and treatment
#11440
middle Confidence
Subject:
PLA2G6
(Protein coding genes)
→
may_be_exploited_as
→
Object:
potential_therapeutic_target
(Potential therapeutic targets)
Original: Metabolic pathway-related genes#may be exploited as#potential targets for diagnosis and treatment
#11438
middle Confidence
Subject:
PLA2G2A
(Protein coding genes)
→
may_be_exploited_as
→
Object:
potential_therapeutic_target
(Potential therapeutic targets)
Original: Metabolic pathway-related genes#may be exploited as#potential targets for diagnosis and treatment
#11436
middle Confidence
Subject:
PLA2G4E
(Protein coding genes)
→
may_be_exploited_as
→
Object:
potential_therapeutic_target
(Potential therapeutic targets)
Original: Metabolic pathway-related genes#may be exploited as#potential targets for diagnosis and treatment
#11366
middle Confidence
Subject:
sphenoid_resection
(Surgery)
→
was_performed_for
→
Object:
residual_tumor_in_tracheal_cartilaginous_portion
(Residual tumor)
Original: Sphenoid resection#was performed for#residual tumor in tracheal cartilaginous portion
#11217
middle Confidence
Subject:
Splenectomy
(Surgery)
→
was_performed_with
→
Object:
partial_colon_resection
(Surgery)
Original: Splenectomy#was performed with#partial colon resection
#10767
middle Confidence
Subject:
Liraglutide
(drug)
→
alleviates
→
Object:
senescence
(Cellular Processes)
Original: Liraglutide#alleviates#BEAS-2B cell senescence induced by high glucose
#10676
middle Confidence
Subject:
CDK4_inhibitors
(Targeted drugs)
→
possess
→
Object:
anti_tumour_activity_in_vitro
(Antitumor activity)
Original: CDK4 inhibitors#possess#anti-tumour activity in vitro
#10663
middle Confidence
Subject:
Bone marrow-derived mesenchymal stem cells
(Stem Cells)
→
result_in
→
Object:
decrease_in_gastric_lesions
(Pathological process)
Original: Infusion of BMMSCs#resulted in#a notable decrease in gastric lesions
#10118
middle Confidence
Subject:
stem_cells
(Stem Cells)
→
have_potential_in
→
Object:
treatment_of_gastric_lesions
(Stem cell therapy applications)
Original: Limited research#has explored#the potential of stem cells in the treatment of gastric lesions
#7324
middle Confidence
Subject:
Accurate_diagnosis
(Diagnostic behavior)
→
is_important_for
→
Object:
Appropriate_clinical_disease_management_in_PRCC
(Clinical management)
Original: accurate diagnosis#is important for#appropriate clinical disease management in papillary renal cell carcinoma
#6725
middle Confidence
Subject:
cytological_findings
(Cytological findings)
→
enables
→
Object:
Mastectomy
(Surgical treatment)
Original: Clinical evaluation and cytological findings#enable#mastectomy for Paget's disease
#6724
middle Confidence
Subject:
clinical_evaluation
(Clinical evaluation)
→
enables
→
Object:
Mastectomy
(Surgical treatment)
Original: Clinical evaluation and cytological findings#enable#mastectomy for Paget's disease
#6562
middle Confidence
Subject:
AgNOR
(Nucleolar Organizing Region-associated Protein)
→
is_observed_in
→
Object:
tumors_with_poor_chemotherapy_response
(Response to treatment)
Original: High AgNOR counts#are observed in#late stage tumors/ grade 3 carcinomas/ and tumors with poor chemotherapy response
#6558
middle Confidence
Subject:
AgNOR
(Nucleolar Organizing Region-associated Protein)
→
correlates_with
→
Object:
response_to_chemotherapy
(Response to treatment)
Original: AgNOR count#correlates with#clinical stage/ histologic grade/ response to chemotherapy/ and biologic behavior
#6550
middle Confidence
Subject:
cell_cycle_regulation
(Cellular Processes)
→
suggests
→
Object:
novel_anticancer_drug_design_avenues
(Therapeutic Development)
Original: Insights into cell cycle regulation#suggest#novel avenues to design anticancer drugs
#6424
middle Confidence
Subject:
non-genotoxic_chemotherapeutic_approaches
(Chemotherapy strategy)
→
target
→
Object:
nucleolus
(Subcellular structure)
Original: Non-genotoxic chemotherapeutic approaches#target#the nucleolus
#6328
middle Confidence
Subject:
characterization_techniques
(Technical methods)
→
used_for
→
Object:
patient_treatment
(Clinical treatment)
Original: Identification of prostatic stem cells#requires#techniques for characterization of stem cells for patient treatment
#5851
middle Confidence
Subject:
chemotherapy
(Chemotherapy drugs)
→
was_received_by
→
Object:
progressive_disease_case
(Disease Cases)
Original: 23 cases with progressive disease#received#chemotherapy
#5050
middle Confidence
Subject:
Gamma-linolenic_acid
(fatty acid)
→
shows
→
Object:
differential_cytotoxic_effects_on_HeLa_cells
(Cytotoxic phenotype)
Original: Gamma-linolenic acid#shows#differential cytotoxic effects on MG-63 and HeLa cells
#5049
middle Confidence
Subject:
Gamma-linolenic_acid
(fatty acid)
→
shows
→
Object:
differential_cytotoxic_effects_on_MG-63_cells
(Cytotoxic phenotype)
Original: Gamma-linolenic acid#shows#differential cytotoxic effects on MG-63 and HeLa cells
#4709
middle Confidence
Subject:
distal_pancreatectomy_with_splenectomy
(Surgery)
→
was_performed_for
→
Object:
metastases
(Disease phenotype)
Original: distal pancreatectomy with splenectomy#was performed for#metastases
#4608
middle Confidence
Subject:
patients
(patient)
→
received
→
Object:
chemotherapy
(Chemotherapy drugs)
Original: 2 patients#received#chemotherapy
#4135
low Confidence
Subject:
patient
(patient)
→
treated_with
→
Object:
Salicylazosulfapyridine
(drug)
Original: Patient#treated with#salicylazosulfapyridine
#3939
low Confidence
Subject:
Patient
(patient)
→
underwent
→
Object:
subtotal_resection
(Surgical method)
Original: Four patients#underwent#a subtotal resection (STR)
#3290
low Confidence
Subject:
FNAC
(Cytology)
→
is_useful_for
→
Object:
management_of_extranodal_NHL_of_tongue
(Clinical management)
Original: FNAC#may be useful for#rapid diagnosis and management of extranodal NHL of the tongue
#2931
low Confidence
Subject:
molecular_targets
(Molecular targets)
→
provide
→
Object:
treatment_strategies_for_thyroid_cancer
(Treatment Process)
Original: Molecular targets#could provide#opportunities for diagnostic/ prognostic/ and treatment strategies for thyroid cancer
#1912
low Confidence
Subject:
distal_gastrectomy
(Surgery)
→
is_performed_with
→
Object:
Vagotomy
(Surgery)
Original: a 50% distal gastrectomy#was performed with#vagotomy
#738
low Confidence
Subject:
rRNA_methylases
(Enzymes)
→
may_provide
→
Object:
favorable_site_for_action_by_cancer_chemotherapeutic_agents
(Drug Targets)
Original: rRNA methylases#may provide#a favorable site for selective action by cancer chemotherapeutic agents
#527
low Confidence
Subject:
perianal_lesion
(Pathological changes)
→
was_resected
→
Object:
not_specified
(not_specified)
Original: Knee and perianal lesions#were resected and#inguinal sentinel node biopsy was performed
#526
low Confidence
Subject:
knee_lesion
(Pathological changes)
→
was_resected
→
Object:
not_specified
(not_specified)
Original: Knee and perianal lesions#were resected and#inguinal sentinel node biopsy was performed
#294
low Confidence
Subject:
resection
(Treatment)
→
applied_for
→
Object:
extramammary_Paget's_disease_(EMPD)
(disease)
Original: man#underwent#resection of the left axillary skin secondary to extramammary Paget's disease (EMPD)
#293
low Confidence
Subject:
man
(patient)
→
underwent
→
Object:
resection
(Treatment)
Original: man#underwent#resection of the left axillary skin secondary to extramammary Paget's disease (EMPD)
#64
low Confidence
Subject:
new_therapeutic_targets
(Therapeutic targets)
→
are_needed_for
→
Object:
cancer
(Tumor)
Original: new therapeutic targets#are urgently needed for#cancer