List of serched triples

A total of 22252 records found

#20412 high Confidence
Subject: PLK5 (Protein kinase)
leads_to
Object: cell_cycle_arrest_in_G1 (Cell cycle arrest)
Original: Ectopic expression of Plk5#leads to#cell cycle arrest in G1
🏥 not_specified 🧬 PLK5 📄 PMID: 20100802
#20411 high Confidence
Subject: PLK1 (Protein kinase)
is_involved_in
Object: cell_cycle_regulation (Cell cycle regulation)
Original: Polo-like kinases (Plk1-4)#are involved in#cell cycle regulation and DNA damage response
🏥 not_specified 🧬 PLK1/PLK2/PLK3/PLK4 📄 PMID: 20100802
#20410 high Confidence
Subject: ionizing_radiation (Physical factors)
leads_to
Object: p53_stabilization (Protein stabilization)
Original: Ionizing radiation#leads to#stabilization and activation of p53
🏥 not_specified 🧬 TP53 📄 PMID: 15195142
#20409 high Confidence
Subject: ionizing_radiation (Physical factors)
leads_to
Object: p53_activation (Transcription factor activation)
Original: Ionizing radiation#leads to#stabilization and activation of p53
🏥 not_specified 🧬 TP53 📄 PMID: 15195142
#20408 high Confidence
Subject: RNA_polymerase_I (Transcriptase)
transcribes
Object: rRNA_genes (rRNA gene)
Original: RNA polymerase I (Pol I)#transcribes#rRNA genes in nucleolus
🏥 not_specified 🧬 POLR1 📄 PMID: 23962978
#20407 high Confidence
Subject: NCL (Ribonucleoprotein)
is_involved_in
Object: miR-15a/16_biogenesis_primary_to_precursor (miRNA biogenesis events)
Original: Nucleolin#is involved in#biogenesis of miR-15a/16 at primary to precursor stage
🏥 not_specified 🧬 NCL 📄 PMID: 22049078
#20406 high Confidence
Subject: nucleoli (Nucleolus)
form_around
Object: nucleolar_organizer_regions (Nucleolar organizing region)
Original: Nucleoli#form around#nucleolar organizer regions (NORs)
🏥 not_specified 📄 PMID: 32332163
#20405 high Confidence
Subject: FBL (Ribosome biogenesis protein)
regulates
Object: tumorigenesis (Tumor development process)
Original: FBL#regulates#tumorigenesis and DNA damage response
🏥 Tumorigenesis 🧬 FBL 📄 PMID: 37489617
#20404 high Confidence
Subject: FBL (Ribosome biogenesis protein)
promotes
Object: cancer_cell_resistance_to_DNA_damage (Cellular resistance)
Original: FBL#promotes#cancer cell resistance to DNA damage and BRCA1 transcription via YBX1
🏥 Treatment related 🧬 FBL/BRCA1/YBX1 📄 PMID: 37489617
#20403 high Confidence
Subject: aberrant_ribosome_biogenesis (Abnormal ribosome)
contributes_to
Object: cellular_transformation (Cell transformation)
Original: Aberrant ribosome biogenesis and epigenetic control disruption#contribute to#cellular transformation
🏥 not_specified 📄 PMID: 17994099
#20402 high Confidence
Subject: Pes1 (Ribosome biogenesis protein)
contains
Object: BRCT_domain (Protein domain)
Original: Pes1#contains#a BRCT-domain
🏥 not_specified 🧬 Pes1 📄 PMID: 17189298
#20401 high Confidence
Subject: nucleostemin (protein)
plays_essential_role_in
Object: cancer_cell_proliferation (Tumor cell proliferation)
Original: Nucleostemin#plays#an essential role in maintaining continuous proliferation of stem cells and cancer cells
🏥 Tumor proliferation 📄 PMID: 17158916
#20400 high Confidence
Subject: nucleostemin (protein)
plays_essential_role_in
Object: stem_cell_proliferation (Stem cell proliferation)
Original: Nucleostemin#plays#an essential role in maintaining continuous proliferation of stem cells and cancer cells
🏥 Stem cell maintenance 📄 PMID: 17158916
#20399 high Confidence
Subject: NPM1 (Protein coding genes)
leads_to
Object: aberrant_cytoplasmic_localization (Subcellular localization)
Original: Mutations in NPM1#lead to#aberrant cytoplasmic localization in AML
🏥 Pathogenesis 🧬 NPM1 📄 PMID: 18625840
#20398 high Confidence
Subject: NPM1 (Protein coding genes)
mutated_in
Object: AML (disease)
Original: Mutations in NPM1#lead to#aberrant cytoplasmic localization in AML
🏥 Diagnosis/pathogenesis 🧬 NPM1 📄 PMID: 18625840
#20397 high Confidence
Subject: SNORA7B (Small nuclear RNA)
reduces
Object: cell_proliferation (Cellular Processes)
Original: CRISPR/Cas9 snoRNA knockout screen#revealed#SNORA65/ SNORA7A/ SNORA7B reduce proliferation in lung cancer cells
🏥 Tumor progression related 🧬 SNORA65/SNORA7A/SNORA7B 📄 PMID: 33288886
#20396 high Confidence
Subject: SNORA7A (Small nuclear RNA)
reduces
Object: cell_proliferation (Cellular Processes)
Original: CRISPR/Cas9 snoRNA knockout screen#revealed#SNORA65/ SNORA7A/ SNORA7B reduce proliferation in lung cancer cells
🏥 Tumor progression related 🧬 SNORA65/SNORA7A/SNORA7B 📄 PMID: 33288886
#20395 high Confidence
Subject: SNORA65 (Small nuclear RNA)
reduces
Object: cell_proliferation (Cellular Processes)
Original: CRISPR/Cas9 snoRNA knockout screen#revealed#SNORA65/ SNORA7A/ SNORA7B reduce proliferation in lung cancer cells
🏥 Tumor progression related 🧬 SNORA65/SNORA7A/SNORA7B 📄 PMID: 33288886
#20394 high Confidence
Subject: mTORC1 (Protein complex)
promotes
Object: ribosome_biogenesis (Ribosome biogenesis process)
Original: mTORC1#promotes#ribosome biogenesis
🏥 not_specified 🧬 MTOR 📄 PMID: 22121221
#20393 high Confidence
Subject: NCL (Ribosome-associated proteins)
is_involved_in
Object: microRNA_processing (miRNA processing)
Original: NCL#is involved in#microRNA processing
🏥 not_specified 🧬 NCL 📄 PMID: 28751161