临床相关性：Treatment related
A total of 52 records found
#21789
high Confidence
Subject:
Systemic_anaplastic_large_cell_lymphoma
(Tumor)
→
was_treated_with
→
Object:
CHOP
(Chemotherapy drugs)
Original: patient#was put on#a regime of CHOP and is disease-free 33 months after diagnosis
#21580
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
sensitizes
→
Object:
tumor_cells_to_DNA_crosslinking_agents
(Cellular drug sensitivity)
Original: Knockdown of FBL#sensitizes#tumor cells to DNA crosslinking agents
#21103
high Confidence
Subject:
patients_with_ccRCC
(patient)
→
underwent
→
Object:
partial_nephrectomy
(Surgery)
Original: 3865 patients#underwent#radical or partial nephrectomy for unilateral/ sporadic ccRCC
#21102
high Confidence
Subject:
patients_with_ccRCC
(patient)
→
underwent
→
Object:
radical_nephrectomy
(Surgery)
Original: 3865 patients#underwent#radical or partial nephrectomy for unilateral/ sporadic ccRCC
#20525
high Confidence
Subject:
RNA_polymerase_I_transcriptional_complex
(Transcription complex)
→
is_inhibited_by
→
Object:
actinomycin_D
(Small molecule drugs)
Original: Fluorescence of RNA polymerase I transcriptional complexes#was diminished by#actinomycin D
#20471
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion_by
→
Object:
AVN-944
(Chemotherapy drugs)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#translocation of nucleolar proteins to the nucleoplasm
#20470
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion_by
→
Object:
MPA
(Chemotherapy drugs)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#translocation of nucleolar proteins to the nucleoplasm
#20469
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion_by
→
Object:
AVN-944
(Chemotherapy drugs)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#a reduction in levels of 45S precursor rRNA synthesis
#20468
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion_by
→
Object:
MPA
(Chemotherapy drugs)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#a reduction in levels of 45S precursor rRNA synthesis
#20404
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
promotes
→
Object:
cancer_cell_resistance_to_DNA_damage
(Cellular resistance)
Original: FBL#promotes#cancer cell resistance to DNA damage and BRCA1 transcription via YBX1
#20356
high Confidence
Subject:
Oxaliplatin
(Chemotherapy drugs)
→
activates
→
Object:
DNA_damage_response
(Cellular Processes)
Original: oxaliplatin#activated#DNA damage response
#20076
high Confidence
Subject:
guanine_nucleotide_depletion
(Metabolic status)
→
causes
→
Object:
nucleolar_protein_translocation
(Subcellular structural changes)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#translocation of nucleolar proteins to the nucleoplasm
#20075
high Confidence
Subject:
guanine_nucleotide
(Small molecule metabolites)
→
depletion
→
Object:
45S_precursor_rRNA_synthesis
(rRNA transcription synthesis)
Original: Depletion of guanine nucleotides by MPA and AVN-944#causes#a reduction in levels of 45S precursor rRNA synthesis
#19522
middle Confidence
Subject:
1-beta-D-arabinofuranosylcytosine
(Chemotherapy drugs)
→
induces
→
Object:
differentiation_of_neuroblasts
(Cell differentiation)
Original: 1-beta-D-arabinofuranosylcytosine#induces#differentiation characterized by neuron-like processes and neuroblast-like cells
#19521
middle Confidence
Subject:
1-beta-D-arabinofuranosylcytosine
(Chemotherapy drugs)
→
induces
→
Object:
differentiation_of_neuron-like_cells
(Cell differentiation)
Original: 1-beta-D-arabinofuranosylcytosine#induces#differentiation characterized by neuron-like processes and neuroblast-like cells
#19138
middle Confidence
Subject:
IL2R_expression
(Cytokine receptors)
→
stimulates
→
Object:
malignant_cell_proliferation
(Cell proliferation)
Original: IL-2 and IL-2R expression#stimulate#proliferation of malignant cells
#19137
middle Confidence
Subject:
IL2_expression
(Cytokines)
→
stimulates
→
Object:
malignant_cell_proliferation
(Cell proliferation)
Original: IL-2 and IL-2R expression#stimulate#proliferation of malignant cells
#18907
middle Confidence
Subject:
celecoxib
(Chemotherapy drugs)
→
decreases
→
Object:
AgNORs_in_beta-catenin_accumulated_crypts
(Nucleolar organizing region)
Original: Exposure to celecoxib#decreases#numbers of silver-stained nucleolar organizer regions (AgNORs) in beta-catenin-accumulated crypts
#18591
middle Confidence
Subject:
KYN-54
(Small molecule drugs)
→
decreases
→
Object:
AgNORs
(Nucleolar organizing region)
Original: KYN-54#decreases#BrdU labeling index and AgNORs in tongue squamous epithelium
#18590
middle Confidence
Subject:
KYN-54
(Small molecule drugs)
→
decreases
→
Object:
BrdU_labeling_index
(Cell proliferation markers)
Original: KYN-54#decreases#BrdU labeling index and AgNORs in tongue squamous epithelium
#17033
middle Confidence
Subject:
EAPB0503
(Small molecule drugs)
→
restores
→
Object:
wt-NPM1_nucleolar_localization
(Protein localization phenotype)
Original: EAPB0503#restores#wt-NPM1 nucleolar localization in NPM1c AML cells
#17032
middle Confidence
Subject:
EAPB0503
(Small molecule drugs)
→
induces
→
Object:
proteasome-mediated_degradation_of_NPM1c
(Protein degradation phenotype)
Original: EAPB0503#induces#proteasome-mediated degradation of NPM1c
#17025
middle Confidence
Subject:
Olomoucine
(Small molecule drugs)
→
induces
→
Object:
nuclear_accumulation_of_wt_p53
(Protein localization phenotype)
Original: Roscovitine and olomoucine#induce#nuclear accumulation of wt p53 and nucleolar unravelling
#17024
middle Confidence
Subject:
Roscovitine
(Small molecule drugs)
→
induces
→
Object:
nuclear_accumulation_of_wt_p53
(Protein localization phenotype)
Original: Roscovitine and olomoucine#induce#nuclear accumulation of wt p53 and nucleolar unravelling
#16885
middle Confidence
Subject:
Curcumin
(Natural Products)
→
shows
→
Object:
cytotoxicity_toward_cervical_cancer_cells
(Cytotoxicity)
Original: Curcumin#shows#cytotoxicity toward cervical cancer lines
#16884
middle Confidence
Subject:
Curcumin
(Natural Products)
→
induces
→
Object:
apoptosis
(Programmed cell death)
Original: Curcumin#induces#apoptosis in cancer cells
#16736
middle Confidence
Subject:
dexamethasone
(Glucocorticoid drugs)
→
decreases
→
Object:
growth_rate
(Cell proliferation)
Original: dexamethasone induction#decreased#growth rate of transformed 3T3/pSVX120 cells by 62%
#16710
middle Confidence
Subject:
berberine
(Small molecule drugs)
→
exhibits
→
Object:
antitumor_effects
(Anti-tumor effect)
Original: berberine#exhibited#antitumor effects
#16261
middle Confidence
Subject:
PLGA
(Adenomatous tumor)
→
is_associated_with
→
Object:
locoregional_recurrence
(Disease phenotype)
Original: PLGAs#are associated with#multiple locoregional recurrences treated with excision and radiation therapy
#15860
middle Confidence
Subject:
KYN-54
(Small molecule drugs)
→
suppresses
→
Object:
cell_proliferation
(Cellular Processes)
Original: KYN-54#suppresses#cell proliferation
#13829
middle Confidence
Subject:
radiation_therapy
(Therapeutic interventions)
→
affects
→
Object:
endocervical_cells
(Cell Type)
Original: Radiation therapy#affected#endocervical cells
#13828
middle Confidence
Subject:
vaginal_squamous_cells
(Cell Type)
→
show_cytologic_change_after
→
Object:
radiation_therapy
(Therapeutic interventions)
Original: Cytologic changes in cervical and vaginal squamous cells#were described#after radiation therapy
#13827
middle Confidence
Subject:
cervical_cells
(Cell Type)
→
show_cytologic_change_after
→
Object:
radiation_therapy
(Therapeutic interventions)
Original: Cytologic changes in cervical and vaginal squamous cells#were described#after radiation therapy
#12495
middle Confidence
Subject:
IL2RA_expression
(Cytokine receptors)
→
regulates
→
Object:
tumor_cell_proliferation
(Cell proliferation)
Original: Interleukin 2 receptor expression and localisation#regulate#tumor cell proliferation
#12313
middle Confidence
Subject:
MDMX
(Protein regulatory factors)
→
reduces_sensitivity_to
→
Object:
actinomycin_D-induced_growth_arrest
(Drug action phenotype)
Original: Tumor cells overexpressing MDMX#are less sensitive to#actinomycin D-induced growth arrest
#12067
middle Confidence
Subject:
chemotherapeutic_agents
(Chemotherapy drugs)
→
induced
→
Object:
cytomorphological_lesions
(Cell morphology damage)
Original: chemotherapeutic agents#induced#cytomorphological lesions in transitional cell carcinoma
#12061
middle Confidence
Subject:
titanocene_dichloride
(Metallo-organic drugs)
→
induces
→
Object:
ultrastructural_alterations
(Ultrastructural changes)
Original: treatment with titanocene dichloride#induces#histologic and ultrastructural alterations in xenografted human colon adenocarcinoma
#12060
middle Confidence
Subject:
titanocene_dichloride
(Metallo-organic drugs)
→
induces
→
Object:
histologic_alterations
(Histological changes)
Original: treatment with titanocene dichloride#induces#histologic and ultrastructural alterations in xenografted human colon adenocarcinoma
#12001
middle Confidence
Subject:
berberine
(Small molecule drugs)
→
was_used_to_treat
→
Object:
MCF7_cells
(Tumor cells)
Original: berberine#was used to treat#MCF7 cells and MCF12A cells
#11562
middle Confidence
Subject:
Patients
(patient)
→
received
→
Object:
aggressive_chemotherapy
(Treatment options)
Original: Patients#died of#disease following aggressive chemotherapeutic regimens
#10761
middle Confidence
Subject:
IL2RB_blocking_antibody
(Antibody Drugs)
→
reduces
→
Object:
cell_number
(Cell number)
Original: IL-2R beta subunit blocking antibody#reduced#cell numbers in G361 cultures
#9458
middle Confidence
Subject:
orbital_debulking_surgery
(Surgical treatment)
→
was_performed_for
→
Object:
massive_tumor_recurrence_in_right_orbit
(Disease phenotype)
Original: Orbital debulking surgery#was performed for#massive tumor recurrence in the right orbit
#8605
middle Confidence
Subject:
alkylating_agent_chemotherapy
(Chemotherapy drugs)
→
was_applied_prior_to
→
Object:
ANLL_diagnosis
(Disease diagnosis)
Original: patients#had#radiotherapy and/or alkylating agent chemotherapy for other neoplastic disease prior to ANLL diagnosis
#8604
middle Confidence
Subject:
radiotherapy
(Radiation therapy)
→
was_applied_prior_to
→
Object:
ANLL_diagnosis
(Disease diagnosis)
Original: patients#had#radiotherapy and/or alkylating agent chemotherapy for other neoplastic disease prior to ANLL diagnosis
#7996
middle Confidence
Subject:
surgical_resection
(Treatment)
→
performed_in
→
Object:
screen-diagnosed_lung_cancer_patients
(Patient population)
Original: 65 people#underwent#surgical resection for screen-diagnosed lung cancer
#6342
middle Confidence
Subject:
titanocene_dichloride
(Metallo-organic drugs)
→
induces
→
Object:
severe_destruction
(Tissue damage)
Original: severe destruction#induced by#3-fold doses of titanocene dichloride is not reversible
#5477
middle Confidence
Subject:
chemotherapy
(Chemotherapy)
→
was_unsuccessful_in_preventing
→
Object:
metastatic_lesions
(Metastatic lesions)
Original: Postoperative treatment with radiation therapy and chemotherapy#was unsuccessful in preventing#local recurrence and metastatic lesions
#5476
middle Confidence
Subject:
radiation_therapy
(Radiation therapy)
→
was_unsuccessful_in_preventing
→
Object:
metastatic_lesions
(Metastatic lesions)
Original: Postoperative treatment with radiation therapy and chemotherapy#was unsuccessful in preventing#local recurrence and metastatic lesions
#5475
middle Confidence
Subject:
chemotherapy
(Chemotherapy)
→
was_unsuccessful_in_preventing
→
Object:
local_recurrence
(Tumor recurrence)
Original: Postoperative treatment with radiation therapy and chemotherapy#was unsuccessful in preventing#local recurrence and metastatic lesions
#5474
middle Confidence
Subject:
radiation_therapy
(Radiation therapy)
→
was_unsuccessful_in_preventing
→
Object:
local_recurrence
(Tumor recurrence)
Original: Postoperative treatment with radiation therapy and chemotherapy#was unsuccessful in preventing#local recurrence and metastatic lesions
#4138
low Confidence
Subject:
patients
(patient)
→
were_on
→
Object:
hormone_therapy
(Hormone therapy)
Original: only two of 44 patients#were on#hormone therapy at the time of biopsy
#3841
low Confidence
Subject:
patient_26_years_old
(patient)
→
was_operated_for
→
Object:
tumor_of_cerebellar_vermis
(Tumor)
Original: a 26 years old patient#was operated for#a tumor of cerebellar vermix