Search results of triples
A total of 64 records found
#22132
high Confidence
Subject:
FBL_gene
(Protein coding genes)
→
is_crucial_for
→
Object:
eukaryotic_cells
(Eukaryotic cells)
Original: FBL gene#is crucial for#eukaryotic cells
#21660
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
is_one_of
→
Object:
most_studied_nucleolar_proteins
(Nucleolar proteins)
Original: FBL#is one of#the most studied nucleolar proteins
#21659
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
is_expressed_in
→
Object:
nucleolus_of_eukaryotes
(Cellular substructure)
Original: FBL#is expressed in#the nucleolus of eukaryotes
#21658
high Confidence
Subject:
FBL_protein
(Ribosome biogenesis protein)
→
contains
→
Object:
methyltransferase_domain
(Protein domain)
Original: FBL protein#contains#GAR domain and methyltransferase domain
#21657
high Confidence
Subject:
FBL_protein
(Ribosome biogenesis protein)
→
contains
→
Object:
GAR_domain
(Protein domain)
Original: FBL protein#contains#GAR domain and methyltransferase domain
#21656
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
is_localized_in
→
Object:
dense_fibrillar_component_of_nucleolus
(Cellular substructure)
Original: FBL#is localized in#the dense fibrillar component of the nucleolus
#21655
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
is
→
Object:
nucleolar_protein
(Nucleolar proteins)
Original: Fibrillarin (FBL)#is#a highly conserved nucleolar protein
#21642
high Confidence
Subject:
MYC
(Protein coding genes)
→
amplification_correlates_with
→
Object:
overexpression_of_MYC
(Protein expression)
Original: C-MYC amplification#was correlated with#overexpression of C-MYC/ TERT/ and FBL
#21620
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
involved_in
→
Object:
ribosome_assembly
(Molecular complex assembly)
Original: Fibrillarin#is involved in#pre-rRNA processing/ methylation/ and ribosome assembly
#21619
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
involved_in
→
Object:
rRNA_methylation
(Molecular modification)
Original: Fibrillarin#is involved in#pre-rRNA processing/ methylation/ and ribosome assembly
#21618
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
involved_in
→
Object:
pre-rRNA_processing
(Molecular Process)
Original: Fibrillarin#is involved in#pre-rRNA processing/ methylation/ and ribosome assembly
#21580
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
sensitizes
→
Object:
tumor_cells_to_DNA_crosslinking_agents
(Cellular drug sensitivity)
Original: Knockdown of FBL#sensitizes#tumor cells to DNA crosslinking agents
#21579
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
is_responsible_for
→
Object:
methylation_of_ribosomal_RNA
(Molecular modification)
Original: Fibrillarin (FBL)#is responsible for#methylation of ribosomal RNA and proteins
#20422
high Confidence
Subject:
Fibrillarin
(Ribosomal proteases)
→
performs
→
Object:
ribomethylation in eukaryotic ribosomes
(Molecular modification events)
Original: Fibrillarin#performs#ribomethylation in eukaryotic ribosomes
#20413
high Confidence
Subject:
fibrillarin
(RNA methyltransferase)
→
is_responsible_for
→
Object:
rRNA_methylation
(RNA modification)
Original: Fibrillarin#is responsible for#rRNA methylation in the nucleolus
#20405
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
regulates
→
Object:
tumorigenesis
(Tumor development process)
Original: FBL#regulates#tumorigenesis and DNA damage response
#20404
high Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
promotes
→
Object:
cancer_cell_resistance_to_DNA_damage
(Cellular resistance)
Original: FBL#promotes#cancer cell resistance to DNA damage and BRCA1 transcription via YBX1
#20353
high Confidence
Subject:
fibrillarin
(Ribosome-associated proteins)
→
is_overexpressed_in
→
Object:
prostate_adenocarcinomas
(Tumor tissue)
Original: fibrillarin#is overexpressed in#PIN lesions and prostate adenocarcinomas
#20352
high Confidence
Subject:
fibrillarin
(Ribosome-associated proteins)
→
is_overexpressed_in
→
Object:
PIN_lesions
(Preneoplastic lesions)
Original: fibrillarin#is overexpressed in#PIN lesions and prostate adenocarcinomas
#20062
high Confidence
Subject:
NOLC1
(Nucleolus-associated protein)
→
interacts_with
→
Object:
fibrillarin
(RNA methyltransferase)
Original: NOLC1#interacts with#fibrillarin in the nucleolus
#19197
middle Confidence
Subject:
GAR_domain_of_FBL
(Protein domain)
→
regulates
→
Object:
intracellular_phase_separation
(Cell phase separation)
Original: GAR structural domain of FBL#regulates#intracellular phase separation
#19157
middle Confidence
Subject:
MYC
(Protein coding genes)
→
amplification_correlates_with
→
Object:
overexpression_of_FBL
(Protein expression)
Original: C-MYC amplification#was correlated with#overexpression of C-MYC/ TERT/ and FBL
#19156
middle Confidence
Subject:
MYC
(Protein coding genes)
→
amplification_correlates_with
→
Object:
overexpression_of_TERT
(Protein expression)
Original: C-MYC amplification#was correlated with#overexpression of C-MYC/ TERT/ and FBL
#19062
middle Confidence
Subject:
Fibrillarin
(Ribosomal proteins)
→
is_component_of
→
Object:
nucleolar_U3_RNP
(Small nucleolar ribonucleoprotein)
Original: Fibrillarin#is a component of#nucleolar U3 RNP
#19032
middle Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
is_responsible_for
→
Object:
methylation_of_ribosomal_proteins
(Molecular modification)
Original: Fibrillarin (FBL)#is responsible for#methylation of ribosomal RNA and proteins
#19031
middle Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
promotes
→
Object:
BRCA1_transcription
(Transcriptional activation)
Original: FBL#promotes#cancer cell resistance to DNA damage and BRCA1 transcription via YBX1
#19002
middle Confidence
Subject:
fibrillarin
(Ribosomal proteins)
→
engaged_in
→
Object:
preribosomal_RNA_processing
(rRNA processing)
Original: fibrillarin#is engaged in#preribosomal RNA processing
#18987
middle Confidence
Subject:
FBL
(Ribosomal proteins)
→
is_required_for
→
Object:
rRNA_processing
(Molecular modification regulation)
Original: FBL (encoding fibrillarin)#is required for#proliferation/ clonogenic survival/ and proper rRNA accumulation/processing in human prostate cancer cells
#18986
middle Confidence
Subject:
FBL
(Ribosomal proteins)
→
is_required_for
→
Object:
rRNA_accumulation
(Small molecule metabolites)
Original: FBL (encoding fibrillarin)#is required for#proliferation/ clonogenic survival/ and proper rRNA accumulation/processing in human prostate cancer cells
#18985
middle Confidence
Subject:
FBL
(Ribosomal proteins)
→
is_required_for
→
Object:
clonogenic_survival
(Cellular Processes)
Original: FBL (encoding fibrillarin)#is required for#proliferation/ clonogenic survival/ and proper rRNA accumulation/processing in human prostate cancer cells
#18984
middle Confidence
Subject:
FBL
(Ribosomal proteins)
→
is_required_for
→
Object:
proliferation
(Cellular Processes)
Original: FBL (encoding fibrillarin)#is required for#proliferation/ clonogenic survival/ and proper rRNA accumulation/processing in human prostate cancer cells
#16954
middle Confidence
Subject:
SNORD44-derived_RNA_120nt
(Noncoding RNA)
→
binds_to
→
Object:
fibrillarin
(protein)
Original: 120 nt SNORD44-derived RNA#binds to#fibrillarin
#16883
middle Confidence
Subject:
KLF16
(Transcription Factors)
→
interacts_with
→
Object:
FBL
(Nucleolar proteins)
Original: KLF16#interacts with#NPM1 and FBL for nucleolar homeostasis
#16882
middle Confidence
Subject:
KLF16
(Transcription Factors)
→
interacts_with
→
Object:
NPM1
(Nucleolar proteins)
Original: KLF16#interacts with#NPM1 and FBL for nucleolar homeostasis
#16838
middle Confidence
Subject:
FBL
(Ribosome biogenesis protein)
→
regulates
→
Object:
DNA_damage_response
(DNA Damage Response)
Original: FBL#regulates#tumorigenesis and DNA damage response
#12561
middle Confidence
Subject:
RNP_domain
(Protein domain)
→
is_prerequisite_for
→
Object:
correct_targeting_of_fibrillarin
(Protein localization)
Original: RNP domain#is a prerequisite for#correct targeting of fibrillarin
#12560
middle Confidence
Subject:
fibrolarin_structural_domains
(Protein domain)
→
are_required_for
→
Object:
CBs_localization
(Subcellular localization)
Original: Specific structural domains of fibrillarin#are required for#intranuclear localization to nucleoli and CBs
#12559
middle Confidence
Subject:
fibrolarin_structural_domains
(Protein domain)
→
are_required_for
→
Object:
intranuclear_localization
(Subcellular localization)
Original: Specific structural domains of fibrillarin#are required for#intranuclear localization to nucleoli and CBs
#12139
middle Confidence
Subject:
bacterial_infection
(Infection status)
→
reduces
→
Object:
fibrillarin_levels
(Ribosomal protein levels)
Original: bacterial infection#reduces#nucleolar size and fibrillarin levels in mammalian cells
#12138
middle Confidence
Subject:
bacterial_infection
(Infection status)
→
reduces
→
Object:
nucleolar_size
(Cell structure characteristics)
Original: bacterial infection#reduces#nucleolar size and fibrillarin levels in mammalian cells
#12034
middle Confidence
Subject:
Fibrillarin
(Ribosomal proteins)
→
downregulated_in
→
Object:
nucleoplasm
(Subcellular structure)
Original: Fibrillarin#was found in low quantities in#fibrillar centers and nucleoplasm after RAP treatment
#12033
middle Confidence
Subject:
Fibrillarin
(Ribosomal proteins)
→
downregulated_in
→
Object:
fibrillar_centers
(Subcellular structure)
Original: Fibrillarin#was found in low quantities in#fibrillar centers and nucleoplasm after RAP treatment
#11984
middle Confidence
Subject:
HOXC6_protein
(Transcription Factors)
→
partially_overlaps_with
→
Object:
fibrillarin
(Ribosome-associated proteins)
Original: HOXC6 protein#partially overlaps with#fibrillarin in nucleoli
#6482
middle Confidence
Subject:
nucleolar_stress
(Cellular stress response)
→
is_shown_by
→
Object:
upregulation_of_p27kip1
(Cell cycle regulatory proteins)
Original: Nucleolar stress#is shown by#decreased nascent pre-rRNA synthesis/ fibrillarin perinucleolar cap formation/ and upregulation of p27kip1
#6481
middle Confidence
Subject:
nucleolar_stress
(Cellular stress response)
→
is_shown_by
→
Object:
fibrillarin_perinucleolar_cap_formation
(Changes in nucleolar structure)
Original: Nucleolar stress#is shown by#decreased nascent pre-rRNA synthesis/ fibrillarin perinucleolar cap formation/ and upregulation of p27kip1
#6480
middle Confidence
Subject:
nucleolar_stress
(Cellular stress response)
→
is_shown_by
→
Object:
decreased_nascent_pre-rRNA_synthesis
(rRNA synthesis)
Original: Nucleolar stress#is shown by#decreased nascent pre-rRNA synthesis/ fibrillarin perinucleolar cap formation/ and upregulation of p27kip1
#5858
middle Confidence
Subject:
nucleolar_structure_area_values
(Nuclear structure parameters)
→
is_related_to
→
Object:
fibrillarin
(Ribosomal proteins)
Original: Nucleolar structure area values#are related to#UBF/ DNA topoisomerase I/ fibrillarin/ and AgNOR proteins
#5857
middle Confidence
Subject:
nucleolar_structure_area_values
(Nuclear structure parameters)
→
is_related_to
→
Object:
DNA_topoisomerase_I
(Topoisomerase)
Original: Nucleolar structure area values#are related to#UBF/ DNA topoisomerase I/ fibrillarin/ and AgNOR proteins
#5856
middle Confidence
Subject:
nucleolar_structure_area_values
(Nuclear structure parameters)
→
is_related_to
→
Object:
UBF
(Transcription Factors)
Original: Nucleolar structure area values#are related to#UBF/ DNA topoisomerase I/ fibrillarin/ and AgNOR proteins
#5855
middle Confidence
Subject:
RNA_polymerase_I_transcriptional_activity
(Transcriptional activity)
→
is_directly_related_to
→
Object:
fibrillarin
(Ribosomal proteins)
Original: RNA polymerase I transcriptional activity#is directly related to#UBF/ DNA topoisomerase I/ and fibrillarin
#5854
middle Confidence
Subject:
RNA_polymerase_I_transcriptional_activity
(Transcriptional activity)
→
is_directly_related_to
→
Object:
DNA_topoisomerase_I
(Topoisomerase)
Original: RNA polymerase I transcriptional activity#is directly related to#UBF/ DNA topoisomerase I/ and fibrillarin
#5853
middle Confidence
Subject:
RNA_polymerase_I_transcriptional_activity
(Transcriptional activity)
→
is_directly_related_to
→
Object:
UBF
(Transcription Factors)
Original: RNA polymerase I transcriptional activity#is directly related to#UBF/ DNA topoisomerase I/ and fibrillarin
#4521
middle Confidence
Subject:
insulin-like_peptide_mutants
(Gene mutant)
→
exhibit
→
Object:
downregulated_fibrillarin_expression
(FBL expression)
Original: Dietary restricted fruit flies and insulin-like-peptide mutants#exhibit#small nucleoli and fibrillarin expression
#4520
middle Confidence
Subject:
dietary_restricted_fruit_flies
(Experimental Animal Models)
→
exhibit
→
Object:
downregulated_fibrillarin_expression
(FBL expression)
Original: Dietary restricted fruit flies and insulin-like-peptide mutants#exhibit#small nucleoli and fibrillarin expression
#4519
middle Confidence
Subject:
insulin-like_peptide_mutants
(Gene mutant)
→
exhibit
→
Object:
small_nucleoli
(Nucleolar phenotype)
Original: Dietary restricted fruit flies and insulin-like-peptide mutants#exhibit#small nucleoli and fibrillarin expression
#4518
middle Confidence
Subject:
dietary_restricted_fruit_flies
(Experimental Animal Models)
→
exhibit
→
Object:
small_nucleoli
(Nucleolar phenotype)
Original: Dietary restricted fruit flies and insulin-like-peptide mutants#exhibit#small nucleoli and fibrillarin expression
#4517
middle Confidence
Subject:
long-lived_animals
(Animal phenotype)
→
exhibit
→
Object:
decreased_expression_of_fibrillarin
(FBL expression)
Original: Long-lived animals#exhibit#small nucleoli and decreased expression of rRNA/ ribosomal proteins/ and fibrillarin
#4516
middle Confidence
Subject:
long-lived_animals
(Animal phenotype)
→
exhibit
→
Object:
decreased_expression_of_ribosomal_proteins
(Ribosomal protein expression)
Original: Long-lived animals#exhibit#small nucleoli and decreased expression of rRNA/ ribosomal proteins/ and fibrillarin
#4515
middle Confidence
Subject:
long-lived_animals
(Animal phenotype)
→
exhibit
→
Object:
decreased_expression_of_rRNA
(rRNA expression)
Original: Long-lived animals#exhibit#small nucleoli and decreased expression of rRNA/ ribosomal proteins/ and fibrillarin
#4514
middle Confidence
Subject:
long-lived_animals
(Animal phenotype)
→
exhibit
→
Object:
small_nucleoli
(Nucleolar phenotype)
Original: Long-lived animals#exhibit#small nucleoli and decreased expression of rRNA/ ribosomal proteins/ and fibrillarin
#4290
low Confidence
Subject:
fibrillarin
(Ribosomal proteins)
→
functions_independently_of
→
Object:
major_innate_immunity_mediators
(Immunomodulatory factors)
Original: fibrillarin#functions independently of#major innate immunity mediators
#2948
low Confidence
Subject:
Fibrillarin
(Ribosomal proteins)
→
shifts_staining_pattern_to
→
Object:
homogeneous_nucleolus
(Subcellular structure)
Original: Fibrillarin staining#shifted from#fibrillar centers to a homogeneous staining of the entire nucleolus
#2947
low Confidence
Subject:
Fibrillarin
(Ribosomal proteins)
→
shifts_staining_pattern_from
→
Object:
fibrillar_centers
(Subcellular structure)
Original: Fibrillarin staining#shifted from#fibrillar centers to a homogeneous staining of the entire nucleolus
#181
low Confidence
Subject:
Fibrillarin
(Ribosome-associated proteins)
→
is_homolog_of
→
Object:
B-36
(Protein homologs)
Original: Fibrillarin#is#a putative mammalian homologue of B-36