Search results of triples
A total of 42 records found
#21564
high Confidence
Subject:
ribosome_biogenesis
(Ribosome biogenesis)
→
disruption_kills
→
Object:
tumor_cells
(cancer cell)
Original: Disruption of ribosome biogenesis#kills#tumor cells via nucleolar function disruption
#20317
high Confidence
Subject:
nucleolar_organizer_region_proteins
(Nucleolar Organizing Region Protein)
→
are_markers_of
→
Object:
proliferation
(Cell proliferation)
Original: Nucleolar organizer region proteins#are markers of#DNA transcription and proliferation
#20316
high Confidence
Subject:
nucleolar_organizer_region_proteins
(Nucleolar Organizing Region Protein)
→
are_markers_of
→
Object:
DNA_transcription
(DNA transcription)
Original: Nucleolar organizer region proteins#are markers of#DNA transcription and proliferation
#20069
high Confidence
Subject:
translation_machinery_misregulation
(Protein synthesis mechanism)
→
is_associated_with
→
Object:
cancer
(Disease phenotype)
Original: Mis-regulation of nucleolar functions and translation machinery#has been associated with#many types of cancer
#20068
high Confidence
Subject:
nucleolar_function_misregulation
(Function of cellular substructures)
→
is_associated_with
→
Object:
cancer
(Disease phenotype)
Original: Mis-regulation of nucleolar functions and translation machinery#has been associated with#many types of cancer
#19200
middle Confidence
Subject:
K11E_mutation
(Gene mutation)
→
leads_to
→
Object:
tumor_suppression
(Tumor suppression)
Original: Loss-of-function mutations K11E or E271K#lead to#novel tumor suppression implicating nucleolar helicase DDX24 oncogenicity
#19024
middle Confidence
Subject:
pNUTs
(Protein complex)
→
permit
→
Object:
light-controllable_interrogation_of_ALS-associated_toxicity
(Molecular function)
Original: pNUTs#permit#light-controllable interrogation of nucleolar functions and ALS-associated toxicity
#19023
middle Confidence
Subject:
pNUTs
(Protein complex)
→
permit
→
Object:
light-controllable_interrogation_of_nucleolar_functions
(Molecular function)
Original: pNUTs#permit#light-controllable interrogation of nucleolar functions and ALS-associated toxicity
#16813
middle Confidence
Subject:
aminonucleoside
(Small molecule drugs)
→
does_not_impair
→
Object:
nucleolar_chromatin_template_function
(Nucleolar chromatin template function)
Original: Aminonucleoside#does not impair#template function of nucleolar chromatin
#16791
middle Confidence
Subject:
loss_of_NPM_nucleolar_localization
(Abnormal subcellular localization)
→
leads_to
→
Object:
loss_of_functions_in_DNA-damage_repair
(Molecular Process)
Original: Loss of NPM nucleolar localization#leads to#a loss of functions in ribosome biogenesis or DNA-damage repair
#16790
middle Confidence
Subject:
loss_of_NPM_nucleolar_localization
(Abnormal subcellular localization)
→
leads_to
→
Object:
loss_of_functions_in_ribosome_biogenesis
(Molecular Process)
Original: Loss of NPM nucleolar localization#leads to#a loss of functions in ribosome biogenesis or DNA-damage repair
#16768
middle Confidence
Subject:
SUN1
(Nuclear membrane protein)
→
depletion_causes
→
Object:
reduced_rRNA_synthesis
(rRNA synthesis)
Original: Depletion of SUN1#causes#nucleolar hypertrophy and reduced rRNA synthesis
#16755
middle Confidence
Subject:
nucleolar_proteins
(Nucleolar proteins)
→
are_associated_with
→
Object:
cancer_biology
(Cancer Biology)
Original: Nucleolar and ribosomal proteins#have#functions associated with cancer biology
#16707
middle Confidence
Subject:
nucleolar_function
(Nucleolar function)
→
is_related_with
→
Object:
tumor_mass_growth_rate
(Tumor growth rate)
Original: Relationship between nucleolar size and function#was studied in relation to#tumor mass growth rate
#16706
middle Confidence
Subject:
nucleolar_size
(Nucleolus size)
→
is_related_with
→
Object:
tumor_mass_growth_rate
(Tumor growth rate)
Original: Relationship between nucleolar size and function#was studied in relation to#tumor mass growth rate
#16092
middle Confidence
Subject:
Proteins
(protein)
→
interact_with
→
Object:
NOR_sequences
(DNA sequence)
Original: RNAs and proteins#interact critically with#NOR sequences to organize higher-order nucleolar structure and function in normal and pathological states
#16091
middle Confidence
Subject:
RNAs
(Nucleic acid molecules)
→
interact_with
→
Object:
NOR_sequences
(DNA sequence)
Original: RNAs and proteins#interact critically with#NOR sequences to organize higher-order nucleolar structure and function in normal and pathological states
#12476
middle Confidence
Subject:
nucleolin_mutant
(Protein mutants)
→
shows
→
Object:
redundant_function_in_nucleolar_shape
(Functional redundancy)
Original: Mutants of nucleolin#show#redundant functions in transcription/ rRNA maturation/ and nucleolar shape
#12475
middle Confidence
Subject:
nucleolin_mutant
(Protein mutants)
→
shows
→
Object:
redundant_function_in_rRNA_maturation
(Functional redundancy)
Original: Mutants of nucleolin#show#redundant functions in transcription/ rRNA maturation/ and nucleolar shape
#12474
middle Confidence
Subject:
nucleolin_mutant
(Protein mutants)
→
shows
→
Object:
redundant_function_in_transcription
(Functional redundancy)
Original: Mutants of nucleolin#show#redundant functions in transcription/ rRNA maturation/ and nucleolar shape
#12377
middle Confidence
Subject:
ZNF692
(Transcription Factors)
→
regulates
→
Object:
nucleolar_function
(Subcellular functions)
Original: ZNF692#regulates#nucleolar architecture and function
#12376
middle Confidence
Subject:
ZNF692
(Transcription Factors)
→
regulates
→
Object:
nucleolar_architecture
(Subcellular structure)
Original: ZNF692#regulates#nucleolar architecture and function
#12223
middle Confidence
Subject:
p14ARF_nucleolar_localization
(Protein subcellular localization)
→
is_abrogated_in
→
Object:
p53_deficient_cells
(Cell Model)
Original: p14ARF nucleolar localization#is abrogated in#cells lacking functional p53
#12184
middle Confidence
Subject:
PTEN
(Protein coding genes)
→
disruption_of
→
Object:
ribosomal_biogenesis
(Ribosome biogenesis)
Original: Disruption of PTEN�?alters#rDNA transcription and ribosomal biogenesis
#12183
middle Confidence
Subject:
PTEN
(Protein coding genes)
→
disruption_of
→
Object:
rDNA_transcription
(Transcription process)
Original: Disruption of PTEN�?alters#rDNA transcription and ribosomal biogenesis
#12180
middle Confidence
Subject:
NPM1
(Protein coding genes)
→
is_required_for
→
Object:
nucleolar_localization_of_FBW7gamma
(Subcellular localization)
Original: NPM#is required for#nucleolar localization and stabilization of Fbw7gamma
#12141
middle Confidence
Subject:
RNA_Polymerase_I
(RNA polymerase)
→
is_inhibited_by
→
Object:
small_molecule_inhibitors
(Small molecule inhibitors)
Original: Small molecule inhibitors of RNA Polymerase I#disrupt#nucleolar function
#12112
middle Confidence
Subject:
nucleolar_functions
(Cellular Processes)
→
play_roles_in
→
Object:
cancer_cells
(Cell Type)
Original: Nucleolar functions#play roles in#normal and cancer cells
#10746
middle Confidence
Subject:
p19ARF
(Tumor suppressor proteins)
→
maintains
→
Object:
nucleolar_structure_and_function
(Subcellular structure function)
Original: Basal p19ARF#maintains#nucleolar structure and function
#10691
middle Confidence
Subject:
small_molecule_inhibitors
(Small molecule inhibitors)
→
disrupt
→
Object:
nucleolar_function
(Nucleolar function)
Original: Small molecule inhibitors of RNA Polymerase I#disrupt#nucleolar function
#10145
middle Confidence
Subject:
nucleolar_function
(Nucleolar function)
→
is_compared_between
→
Object:
other_tissue
(Other organizations)
Original: nucleolar function#is compared between#tumors and other tissues
#10144
middle Confidence
Subject:
nucleolar_function
(Nucleolar function)
→
is_compared_between
→
Object:
tumor
(Tumor tissue)
Original: nucleolar function#is compared between#tumors and other tissues
#6225
middle Confidence
Subject:
pituitary_adenomas
(Tumor type)
→
are_analyzed_for
→
Object:
AgNORs
(Molecular detection indicators)
Original: non-functional and functional pituitary adenomas#are analyzed for#argyrophilic nucleolar organizer regions (Ag-NORs)
#5878
middle Confidence
Subject:
nucleolar_morphofunctional_changes
(Changes in cell substructure function)
→
correlate_with
→
Object:
proliferative_activity
(Proliferation activity)
Original: relationships between morphofunctional changes in nucleoli#correlate with#differentiation degree and proliferative activity of cells
#5877
middle Confidence
Subject:
nucleolar_morphofunctional_changes
(Changes in cell substructure function)
→
correlate_with
→
Object:
differentiation_degree
(Degree of differentiation)
Original: relationships between morphofunctional changes in nucleoli#correlate with#differentiation degree and proliferative activity of cells
#2848
low Confidence
Subject:
nucleolar_functions
(Cellular Processes)
→
play_roles_in
→
Object:
normal_cells
(Cell Type)
Original: Nucleolar functions#play roles in#normal and cancer cells
#1751
low Confidence
Subject:
nucleolar_structure_and_function
(Nucleolus structure and function)
→
focuses_on
→
Object:
oocytes_of_amphibians
(Cell Type)
Original: Research on nucleolar structure and function#focuses on#nucleoli in meiotic cells like oocytes of amphibians
#1750
low Confidence
Subject:
nucleolar_structure_and_function
(Nucleolus structure and function)
→
focuses_on
→
Object:
meiotic_cells
(Cell Type)
Original: Research on nucleolar structure and function#focuses on#nucleoli in meiotic cells like oocytes of amphibians
#1749
low Confidence
Subject:
nucleolar_structure_and_function
(Nucleolus structure and function)
→
focuses_on
→
Object:
nucleoli
(Cellular substructure)
Original: Research on nucleolar structure and function#focuses on#nucleoli in meiotic cells like oocytes of amphibians
#1748
low Confidence
Subject:
nucleolar_structure_and_function
(Nucleolus structure and function)
→
focuses_on
→
Object:
somatic_tissue_culture_cells
(Cell Type)
Original: Research on nucleolar structure and function#focuses on#nucleoli in somatic tissue culture cells during interphase
#1747
low Confidence
Subject:
nucleolar_structure_and_function
(Nucleolus structure and function)
→
focuses_on
→
Object:
nucleoli
(Cellular substructure)
Original: Research on nucleolar structure and function#focuses on#nucleoli in somatic tissue culture cells during interphase
#105
low Confidence
Subject:
PPAN
(Ribosome biogenesis-associated protein)
→
function_unknown
→
Object:
nucleolar_stress_response
(Cellular stress response)
Original: The role of PPAN in nucleolar stress response#has remained#elusive