Search results of triples

A total of 23 records found

#22119 high Confidence
Subject: UBF (Transcription Factors)
initiates
Object: rRNA_transcription (Molecular Process)
Original: Upstream binding factor (UBF)#recognizes#ribosomal RNA gene promoter and initiates transcription
🏥 not_specified 🧬 UBTF 📄 PMID: 19718949
#22118 high Confidence
Subject: UBF (Transcription Factors)
recognizes
Object: rRNA_gene_promoter (DNA sequence)
Original: Upstream binding factor (UBF)#recognizes#ribosomal RNA gene promoter and initiates transcription
🏥 not_specified 🧬 UBTF 📄 PMID: 19718949
#19050 middle Confidence
Subject: UBF1-mediated_ECT2_recruitment (Protein complex assembly)
elevates
Object: rRNA_synthesis (Transcription product)
Original: UBF1-mediated ECT2 recruitment#elevates#rRNA synthesis
🏥 Transcriptional regulatory mechanisms 🧬 UBTF/ECT2 📄 PMID: 32350115
#18656 middle Confidence
Subject: upstream_binding_factor(UBF) (Transcription Factors)
distribution_is_uncoupled_from
Object: RNA_Polymerase_I_activity (RNA polymerase activity)
Original: distribution of upstream binding factor (UBF)#is uncoupled from#RNA Polymerase I activity in mitotic cells and upon transcription inhibition
🏥 not_specified 📄 PMID: 21586586
#16890 middle Confidence
Subject: UBTF (Transcription Factors)
mediates_recruitment_of
Object: ECT2 (Guanine nucleotide exchange factor)
Original: UBF1-mediated ECT2 recruitment#promotes#transformed growth
🏥 not_specified 🧬 UBTF/ECT2 📄 PMID: 32350115
#12710 middle Confidence
Subject: UBTF (Transcription Factors)
is_sensitive_alternative_to
Object: AgNOR_staining (Dyeing technology)
Original: UBF staining#is#a sensitive alternative to AgNOR staining for detecting ribosomal activity in malignant tissues
🏥 diagnosis 🧬 UBTF 📄 PMID: 9582531
#12709 middle Confidence
Subject: UBTF (Transcription Factors)
detects
Object: ribosomal_activity (Ribosome activity)
Original: UBF staining#is#a sensitive alternative to AgNOR staining for detecting ribosomal activity in malignant tissues
🏥 not_specified 🧬 UBTF 📄 PMID: 9582531
#12708 middle Confidence
Subject: UBTF (Transcription Factors)
is_sensitive_alternative_to
Object: AgNOR_staining (Dyeing technology)
Original: UBF staining#is#a sensitive alternative to AgNOR staining for detecting ribosomal activity in malignant tissues
🏥 diagnosis 🧬 UBTF 📄 PMID: 9582531
#12707 middle Confidence
Subject: morphological_differences (Cell morphology)
correlate_with
Object: histopathological_evaluation (Histopathological evaluation)
Original: NORs stained with anti-UBF serum#showed#significant morphological differences correlating with histopathological evaluation
🏥 not_specified 🧬 UBTF 📄 PMID: 9582531
#12706 middle Confidence
Subject: UBTF (Transcription Factors)
shows_morphological_differences
Object: malignant_cells (Malignant cells)
Original: NORs stained with anti-UBF serum#showed#significant morphological differences correlating with histopathological evaluation
🏥 not_specified 🧬 UBTF 📄 PMID: 9582531
#12705 middle Confidence
Subject: UBTF (Transcription Factors)
shows_morphological_differences
Object: benign_cells (Benign cells)
Original: NORs stained with anti-UBF serum#showed#significant morphological differences correlating with histopathological evaluation
🏥 not_specified 🧬 UBTF 📄 PMID: 9582531
#12297 middle Confidence
Subject: ECT2 (Guanine nucleotide exchange factor)
promotes
Object: transformed_growth (Cellular Processes)
Original: UBF1-mediated ECT2 recruitment#promotes#transformed growth
🏥 Tumorigenesis 🧬 UBTF/ECT2 📄 PMID: 32350115
#12296 middle Confidence
Subject: UBF1_Ser-412_phosphorylation_site (Protein modification sites)
is_required_for
Object: UBF1-mediated_ECT2_recruitment_to_rDNA (Protein complex assembly)
Original: UBF1 Ser-412 phosphorylation site#is required for#UBF1-mediated ECT2 recruitment to rDNA
🏥 Transcriptional regulatory mechanisms 🧬 UBTF/ECT2 📄 PMID: 32350115
#12295 middle Confidence
Subject: ECT2 (Guanine nucleotide exchange factor)
binds_to
Object: UBF1 (Transcription Factors)
Original: ECT2#binds#UBF1 on rDNA promoter regions
🏥 Transcriptional regulatory mechanisms 🧬 ECT2/UBTF 📄 PMID: 32350115
#12287 middle Confidence
Subject: HDAC1 (Deacetylase)
downregulation_decreases
Object: UBF_association (Protein Interactions)
Original: Downregulation of RUNX2 expression#decreases#association between HDAC1 and UBF
🏥 not_specified 🧬 RUNX2/HDAC1/UBTF 📄 PMID: 22393235
#12286 middle Confidence
Subject: RUNX2 (Transcription Factors)
downregulation_decreases
Object: HDAC1_UBF_association (Protein Interactions)
Original: Downregulation of RUNX2 expression#decreases#association between HDAC1 and UBF
🏥 not_specified 🧬 RUNX2/HDAC1/UBTF 📄 PMID: 22393235
#12208 middle Confidence
Subject: CALI (Optogenetics Tools)
caused
Object: relocalization_of_UBF_from_nucleoli_to_nucleoplasmic_spots (Changes in cell localization)
Original: CALI#caused#relocalization of UBF from nucleoli to nucleoplasmic spots
🏥 not_specified 🧬 UBTF 📄 PMID: 17531085
#8615 middle Confidence
Subject: cytologic_report (Cytology report)
identified
Object: suspicious_smears_for_tumor_cells (Smear suspicious of tumor cells)
Original: cytologic report#identified#five doubtful and seven suspicious smears for tumor cells
🏥 Diagnosis related 📄 PMID: 12775918
#8614 middle Confidence
Subject: cytologic_report (Cytology report)
identified
Object: doubtful_smears_for_tumor_cells (Suspicious tumor cell smear)
Original: cytologic report#identified#five doubtful and seven suspicious smears for tumor cells
🏥 Diagnosis related 📄 PMID: 12775918
#6511 middle Confidence
Subject: UBF (Transcription Factors)
is_in_close_spatial_proximity_with
Object: pKi-67 (Nuclear matrix proteins)
Original: UBF#is in close spatial proximity with#pKi-67
🏥 not_specified 🧬 UBTF/MKI67 📄 PMID: 17531085
#6400 middle Confidence
Subject: PPAN (Ribosome biogenesis-associated protein)
depletion_induces
Object: UBTF_degradation (Protein degradation)
Original: PPAN depletion#induces#NPM and upstream-binding factor (UBF) degradation
🏥 not_specified 🧬 PPAN/NPM1/UBTF 📄 PMID: 25759387
#6399 middle Confidence
Subject: PPAN (Ribosome biogenesis-associated protein)
depletion_induces
Object: NPM1_degradation (Protein degradation)
Original: PPAN depletion#induces#NPM and upstream-binding factor (UBF) degradation
🏥 not_specified 🧬 PPAN/NPM1/UBTF 📄 PMID: 25759387
#3295 low Confidence
Subject: Immunohistochemistry (Immunohistochemistry)
may_help_in
Object: doubtful_cases (Diagnostic Process)
Original: immunohistochemistry#may help in#doubtful cases
🏥 Diagnostic significance 📄 PMID: 9057585