Search results of triples
A total of 50 records found
#22220
high Confidence
Subject:
ribosomal_proteins
(Protein complex)
→
activate
→
Object:
p53_pathway
(signaling pathway)
Original: Ribosomal proteins#activate#p53 tumor suppressor pathway
#22113
high Confidence
Subject:
TP53
(Tumor suppressor genes)
→
acts_as
→
Object:
tumor_suppressor
(Tumor suppressor function)
Original: p14ARF/ARF#acts as#a tumor suppressor through a p53/MDM2-dependent pathway
#21652
high Confidence
Subject:
NPM1
(Nucleolar proteins)
→
facilitates
→
Object:
ribosome_biogenesis
(Molecular complex synthesis)
Original: NPM1#facilitates#ribosome biogenesis and nucleolar stress responses
#21578
high Confidence
Subject:
ribosomal_stress
(Cellular stress)
→
triggers
→
Object:
p53_signaling_pathway_activation
(Signaling pathway activation)
Original: Ribosomal stress#triggers#p53 signaling pathway activation via RPs-MDM2 interactions
#20443
high Confidence
Subject:
TP53
(Tumor suppressor proteins)
→
silenced_in
→
Object:
human_cancers
(Tumor phenotype)
Original: Silencing of retinoblastoma protein and p53 pathways#is associated with#the development of human cancers
#20442
high Confidence
Subject:
RB1
(Tumor suppressor proteins)
→
silenced_in
→
Object:
human_cancers
(Tumor phenotype)
Original: Silencing of retinoblastoma protein and p53 pathways#is associated with#the development of human cancers
#20092
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
ribosome_biogenesis
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#20091
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
centrosome_duplication
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#20000
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
nucleolar_stress_response
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#19918
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
facilitates
→
Object:
nucleolar_stress_response
(Cellular stress response)
Original: NPM1#facilitates#ribosome biogenesis and nucleolar stress responses
#19904
middle Confidence
Subject:
CDKN2A
(Tumor suppressor genes)
→
acts_as
→
Object:
tumor_suppressor
(Tumor suppressor function)
Original: p14ARF/ARF#acts as#a tumor suppressor through a p53/MDM2-dependent pathway
#19882
middle Confidence
Subject:
ribosomal_proteins
(Ribosomal proteins)
→
play_important_role_in
→
Object:
p53_activation_in_response_to_nucleolar_stress
(Stress response)
Original: Ribosomal proteins#play an important role in#p53 activation in response to nucleolar stress
#19092
middle Confidence
Subject:
PICT1
(Nucleolar proteins/signal regulatory proteins)
→
regulates
→
Object:
apoptosis
(Apoptosis)
Original: PICT-1#regulates#apoptosis through the RPL11-MDM2-p53 pathway
#19046
middle Confidence
Subject:
Ribosomal_proteins
(Ribosomal proteins)
→
modulate
→
Object:
MDM2-p53_pathway
(signaling pathway)
Original: Ribosomal proteins#modulate#MDM2-p53 pathway
#19028
middle Confidence
Subject:
RPs-MDM2_interactions
(Protein interactions)
→
activates
→
Object:
p53_signaling_pathway
(signaling pathway)
Original: Ribosomal stress#triggers#p53 signaling pathway activation via RPs-MDM2 interactions
#18983
middle Confidence
Subject:
cytostatics
(Chemotherapy drugs)
→
induce
→
Object:
nucleolar_phenotype_changes
(Cell phenotype changes)
Original: Cytostatics-induced changes of nucleolar phenotype#point to#a potential role of nucleolar components in the execution of active cell death
#17165
middle Confidence
Subject:
PICT1
(Ribosome-associated proteins)
→
regulates
→
Object:
MDM2-TP53_pathway
(signaling pathway)
Original: PICT1#regulates#MDM2-TP53 pathway via interaction with RPL11 in nucleolus
#17146
middle Confidence
Subject:
PSAT1
(Phosphoserine aminotransferase)
→
shows_enrichment_in
→
Object:
P53_signaling_pathway
(signaling pathway)
Original: PSAT1-high group#showed enrichment in#DNA recombination and repair/ nucleotide biosynthesis/ and P53 signaling pathway
#17145
middle Confidence
Subject:
PSAT1
(Phosphoserine aminotransferase)
→
shows_enrichment_in
→
Object:
nucleotide_biosynthesis
(Metabolic Process)
Original: PSAT1-high group#showed enrichment in#DNA recombination and repair/ nucleotide biosynthesis/ and P53 signaling pathway
#17144
middle Confidence
Subject:
PSAT1
(Phosphoserine aminotransferase)
→
shows_enrichment_in
→
Object:
DNA_recombination_and_repair
(Molecular Process)
Original: PSAT1-high group#showed enrichment in#DNA recombination and repair/ nucleotide biosynthesis/ and P53 signaling pathway
#17079
middle Confidence
Subject:
ribosomal_proteins
(Ribosomal proteins)
→
control
→
Object:
tumor_suppressor_pathways
(signaling pathway)
Original: Ribosomal proteins#control#tumor suppressor pathways in response to nucleolar stress
#17057
middle Confidence
Subject:
eif2ak4
(Protein kinase)
→
depletion_induces
→
Object:
TP53_pathway_activation
(Signaling pathway activation)
Original: GCN2 depletion#induces#p53 pathway activation
#17003
middle Confidence
Subject:
nucleolar_pathway
(signaling pathway)
→
connects
→
Object:
p53_activation
(Protein activation events)
Original: Nucleolar pathway#connects#intracellular energy status with p53 activation
#17002
middle Confidence
Subject:
nucleolar_pathway
(signaling pathway)
→
connects
→
Object:
intracellular_energy_status
(Cell metabolic state)
Original: Nucleolar pathway#connects#intracellular energy status with p53 activation
#16976
middle Confidence
Subject:
nucleolar_morphology
(Cell structure characteristics)
→
is_linked_to
→
Object:
stress_responses
(Cellular stress response)
Original: Alterations in nucleolar morphology and protein content#are linked to#control of cell proliferation and stress responses
#16975
middle Confidence
Subject:
nucleolar_morphology
(Cell structure characteristics)
→
is_linked_to
→
Object:
control_of_cell_proliferation
(Cellular Processes)
Original: Alterations in nucleolar morphology and protein content#are linked to#control of cell proliferation and stress responses
#16900
middle Confidence
Subject:
p14
(protein)
→
regulates
→
Object:
p53_stabilization
(Protein stability)
Original: p14#regulates#nucleolar stress response/ ribosome biogenesis/ and p53 stabilization
#16899
middle Confidence
Subject:
p14
(protein)
→
regulates
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: p14#regulates#nucleolar stress response/ ribosome biogenesis/ and p53 stabilization
#16898
middle Confidence
Subject:
p14
(protein)
→
regulates
→
Object:
nucleolar_stress_response
(Cellular stress process)
Original: p14#regulates#nucleolar stress response/ ribosome biogenesis/ and p53 stabilization
#16711
middle Confidence
Subject:
berberine
(Small molecule drugs)
→
causes
→
Object:
nucleolar_stress_response
(Molecular stress response)
Original: berberine#caused#nucleolar stress response
#12493
middle Confidence
Subject:
nucleolar_stress
(Cellular stress)
→
activates
→
Object:
JNK
(Mitogen-activated protein kinase)
Original: Nucleolar stress#activated#Jun N-terminal kinase (JNK) in Nopp140-depleted larvae
#12484
middle Confidence
Subject:
ribosome_dysfunction
(Ribosome dysfunction)
→
activates
→
Object:
p53_pathway
(signaling pathway)
Original: Ribosome dysfunction#activates#p53 pathway
#12418
middle Confidence
Subject:
MDM2
(Ubiquitin ligase)
→
acts_as
→
Object:
tumor_suppressor
(Tumor suppressor function)
Original: p14ARF/ARF#acts as#a tumor suppressor through a p53/MDM2-dependent pathway
#12357
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
supports
→
Object:
central_role_in_rDNA_transcription
(rDNA transcription regulation)
Original: NuMA#supports#a central role in rDNA transcription and p53-independent nucleolar stress response
#12355
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
is_involved_in
→
Object:
p53-mediated_growth_arrest
(Cell cycle arrest)
Original: NuMA#is involved in#DNA damage response/ apoptosis/ and p53-mediated growth arrest under nucleolar stress
#12354
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
is_involved_in
→
Object:
apoptosis
(Apoptosis)
Original: NuMA#is involved in#DNA damage response/ apoptosis/ and p53-mediated growth arrest under nucleolar stress
#12353
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
is_involved_in
→
Object:
DNA_damage_response
(Cellular stress response)
Original: NuMA#is involved in#DNA damage response/ apoptosis/ and p53-mediated growth arrest under nucleolar stress
#12200
middle Confidence
Subject:
PPAN
(Ribosome biogenesis-associated protein)
→
inhibits
→
Object:
mitochondrial_apoptosis_pathway
(Apoptosis pathway)
Original: PPAN#inhibits#mitochondrial apoptosis pathway in a p53-independent manner
#12199
middle Confidence
Subject:
PPAN
(Ribosome biogenesis regulatory protein)
→
defines
→
Object:
p53_independent_nucleolar_stress_response_pathway
(Stress Pathway)
Original: Wnt Target Protein Peter Pan#defines#a novel p53-independent nucleolar stress-response pathway
#12000
middle Confidence
Subject:
DNA_damage_response
(Cellular Processes)
→
triggers
→
Object:
nucleolar_and_ribosomal_stress
(Molecular stress response)
Original: DNA damage response#triggered#nucleolar and ribosomal stress
#10736
middle Confidence
Subject:
p53-independent_pathway
(signaling pathway)
→
regulates
→
Object:
antigen_translocation
(Subcellular structure process)
Original: p53-independent pathway#regulates#nucleolar segregation and antigen translocation in response to DNA damage
#10735
middle Confidence
Subject:
p53-independent_pathway
(signaling pathway)
→
regulates
→
Object:
nucleolar_segregation
(Subcellular structure process)
Original: p53-independent pathway#regulates#nucleolar segregation and antigen translocation in response to DNA damage
#9906
middle Confidence
Subject:
MLF1
(Protein coding genes)
→
functions_upstream_of
→
Object:
CSN3-COP1-p53_pathway
(signaling pathway)
Original: MLF1#functions upstream of#CSN3-COP1-p53 pathway
#6612
middle Confidence
Subject:
PICT1
(Ribosome-associated proteins)
→
interacts_with
→
Object:
RPL11
(Ribosomal proteins)
Original: PICT1#regulates#MDM2-TP53 pathway via interaction with RPL11 in nucleolus
#6536
middle Confidence
Subject:
BRF1
(Transcription Factors)
→
depletion_restores
→
Object:
TP53_pathway_activation
(Signaling pathway activation)
Original: Derepression of small RNA transcripts and p53 pathway activation by GCN2 depletion#is restored by#BRF1 depletion
#6535
middle Confidence
Subject:
BRF1
(Transcription Factors)
→
depletion_restores
→
Object:
small_RNA_transcripts
(Small RNA)
Original: Derepression of small RNA transcripts and p53 pathway activation by GCN2 depletion#is restored by#BRF1 depletion
#6534
middle Confidence
Subject:
eif2ak4
(Protein kinase)
→
depletion_derepresses
→
Object:
TP53_pathway_activation
(Signaling pathway activation)
Original: Derepression of small RNA transcripts and p53 pathway activation by GCN2 depletion#is restored by#BRF1 depletion
#6533
middle Confidence
Subject:
eif2ak4
(Protein kinase)
→
depletion_derepresses
→
Object:
small_RNA_transcripts
(Small RNA)
Original: Derepression of small RNA transcripts and p53 pathway activation by GCN2 depletion#is restored by#BRF1 depletion
#6484
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
supports
→
Object:
p53-independent_nucleolar_stress_response
(Cellular stress response)
Original: NuMA#supports#a central role in rDNA transcription and p53-independent nucleolar stress response
#105
low Confidence
Subject:
PPAN
(Ribosome biogenesis-associated protein)
→
function_unknown
→
Object:
nucleolar_stress_response
(Cellular stress response)
Original: The role of PPAN in nucleolar stress response#has remained#elusive