临床相关性：Cell cycle regulation
A total of 25 records found
#22117
high Confidence
Subject:
RPS14
(Ribosomal proteins)
→
inhibits
→
Object:
CDK6
(Kinase)
Original: RPS14#acts as#a CDK4/6 inhibitor linking ribosome biogenesis defects to cell cycle progression
#22116
high Confidence
Subject:
RPS14
(Ribosomal proteins)
→
inhibits
→
Object:
CDK4
(Kinase)
Original: RPS14#acts as#a CDK4/6 inhibitor linking ribosome biogenesis defects to cell cycle progression
#21654
high Confidence
Subject:
CDK4
(Protein kinase)
→
phosphorylates
→
Object:
retinoblastoma_protein
(Tumor suppressor proteins)
Original: Cyclin D1#activates#cdk4 to produce retinoblastoma protein phosphorylation
#21653
high Confidence
Subject:
Cyclin_D1
(Cell cycle proteins)
→
activates
→
Object:
CDK4
(Protein kinase)
Original: Cyclin D1#activates#cdk4 to produce retinoblastoma protein phosphorylation
#20294
high Confidence
Subject:
MDM2
(Ubiquitin ligase)
→
abrogates
→
Object:
p53-mediated_G1_arrest
(Molecular modification regulation)
Original: MDM2 oncoprotein#abrogates#p53-mediated G1 arrest and apoptosis
#20054
high Confidence
Subject:
SGO2
(Protein coding genes)
→
upregulates
→
Object:
E2F1
(Transcription Factors)
Original: SGO2#facilitated#cell proliferation and regulated cell cycle through upregulating E2F1
#20052
high Confidence
Subject:
SGO2
(Protein coding genes)
→
contributes_to
→
Object:
cell_cycle_progression
(Cell cycle regulation)
Original: SGO2#contributed to#cell cycle progression and reduced cell apoptosis
#17559
middle Confidence
Subject:
Melatonin
(hormone)
→
delays
→
Object:
entry_of_MCF-7_cells_into_mitosis
(Cell cycle events)
Original: Melatonin#delays#entry of MCF-7 cells into mitosis
#17212
middle Confidence
Subject:
p27BBP
(Ribosomal proteins)
→
is_high_in
→
Object:
rapidly_cycling_cells
(Cellular Processes)
Original: p27BBP#is high in#rapidly cycling cells and decreased in apoptotic villous cells
#17066
middle Confidence
Subject:
TP53
(Tumor suppressor proteins)
→
induction_leads_to
→
Object:
CDKN1A_accumulation
(Cell cycle protein inhibitors)
Original: p53 induction#leads to#lineage-specific p21 accumulation and cell cycle arrest in erythroid progenitor cells
#17065
middle Confidence
Subject:
ribosomal_protein_genes
(Ribosomal protein genes)
→
haploinsufficiency_activates
→
Object:
TP53
(Tumor suppressor proteins)
Original: Haploinsufficiency of ribosomal protein genes#activates#p53 in human erythroid progenitor cells
#17062
middle Confidence
Subject:
SENP3
(Deubiquitinase)
→
is_antagonized_by
→
Object:
CDKN2A
(Tumor suppressor genes)
Original: p19(Arf)#antagonizes#Senp3 to induce cell cycle arrest
#17061
middle Confidence
Subject:
CDKN2A
(Tumor suppressor genes)
→
antagonizes
→
Object:
SENP3
(Deubiquitinase)
Original: p19(Arf)#antagonizes#Senp3 to induce cell cycle arrest
#17001
middle Confidence
Subject:
CDKN2A
(Cell cycle inhibitors)
→
regulates
→
Object:
cell_proliferation
(Cell proliferation)
Original: ARF#regulates#cell proliferation via inhibiting B23
#16999
middle Confidence
Subject:
NPM1
(Ribosomal proteins/nucleolar proteins)
→
overexpression_promotes
→
Object:
S_phase_entry
(Cell cycle progression)
Original: Overexpression of B23#promotes#S phase entry in cells lacking p53
#16998
middle Confidence
Subject:
NPM1
(Ribosomal proteins/nucleolar proteins)
→
overexpression_induces
→
Object:
cell_cycle_arrest
(Cell cycle arrest)
Original: Overexpression of B23#induces#cell cycle arrest in normal fibroblasts
#16857
middle Confidence
Subject:
PLK5
(Protein kinase)
→
ectopic_expression_leads_to
→
Object:
decreased_DNA_synthesis
(Cellular Processes)
Original: Ectopic expression of Plk5#leads to#decreased DNA synthesis and apoptosis
#12664
middle Confidence
Subject:
SPC25
(Protein coding genes)
→
regulates
→
Object:
cell_cycle
(Cellular Processes)
Original: SPC25 and co-expressed genes#engaged in#biological processes and signal transduction routes linked to cell cycle and cell division
#12486
middle Confidence
Subject:
CDKN1A
(Cell cycle protein inhibitors)
→
accumulation_leads_to
→
Object:
cell_cycle_arrest
(Cellular Processes)
Original: p53 induction#leads to#lineage-specific p21 accumulation and cell cycle arrest in erythroid progenitor cells
#12484
middle Confidence
Subject:
ribosome_dysfunction
(Ribosome dysfunction)
→
activates
→
Object:
p53_pathway
(signaling pathway)
Original: Ribosome dysfunction#activates#p53 pathway
#12483
middle Confidence
Subject:
RPL11
(Ribosomal proteins)
→
knockdown_abrogates
→
Object:
NS_depletion_induced_p53_activation
(Signaling pathway events)
Original: Knockdown of L5 or L11#abrogates#NS depletion-induced p53 activation and cell cycle arrest
#12482
middle Confidence
Subject:
RPL5
(Ribosomal proteins)
→
knockdown_abrogates
→
Object:
NS_depletion_induced_p53_activation
(Signaling pathway events)
Original: Knockdown of L5 or L11#abrogates#NS depletion-induced p53 activation and cell cycle arrest
#6509
middle Confidence
Subject:
ARF
(Protein coding genes)
→
amplifies
→
Object:
TP53-mediated_response
(Regulation process)
Original: Arf proteins#might amplify#p53-mediated responses in specific conditions and cell cycle periods
#3967
low Confidence
Subject:
MKI67
(Cell cycle related proteins)
→
is_correlated_with
→
Object:
SG2M_phases_of_cell_cycle
(Cell cycle phase)
Original: correlation between Ki-67 and SG2M phases of cell cycle#is#poor
#3370
low Confidence
Subject:
cells
(cell)
→
show
→
Object:
weak_positive_reaction_in_nucleoli
(Nuclear structure)
Original: cells#showed#weak positive reactions in one or two nucleoli during S phase