Search results of triples
A total of 86 records found
#21535
high Confidence
Subject:
NCL
(Nucleolin)
→
is_promising_target_for
→
Object:
treatment_of_gastric_cancer
(Clinical treatment)
Original: nucleolin on cell surface#is a promising target for#treatment of gastric cancer
#20474
high Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
depletion
→
Object:
rDNA_transcription
(Transcription process)
Original: Depletion of nucleolin#inhibits#rDNA transcription
#20473
high Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
is_highly_expressed_in
→
Object:
cancer_cell_lines
(Cell Type)
Original: Nucleolin#is highly expressed in#rapidly dividing cells and cancer cell lines
#20472
high Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
is_highly_expressed_in
→
Object:
rapidly_dividing_cells
(Cell Type)
Original: Nucleolin#is highly expressed in#rapidly dividing cells and cancer cell lines
#20421
high Confidence
Subject:
Nucleolin lactylation
(Protein post-translational modification)
→
promotes
→
Object:
invasion of iCCA cells
(Cellular Processes)
Original: Nucleolin lactylation#promotes#invasion of iCCA cells
#20420
high Confidence
Subject:
NCL
(Ribosomal proteins)
→
correlates_with
→
Object:
iCCA_progression
(Disease phenotype)
Original: Nucleolin#correlates with#iCCA occurrence and progression
#20419
high Confidence
Subject:
NCL
(Ribosomal proteins)
→
correlates_with
→
Object:
iCCA_occurrence
(Disease phenotype)
Original: Nucleolin#correlates with#iCCA occurrence and progression
#20407
high Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_involved_in
→
Object:
miR-15a/16_biogenesis_primary_to_precursor
(miRNA biogenesis events)
Original: Nucleolin#is involved in#biogenesis of miR-15a/16 at primary to precursor stage
#20384
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
cell_membrane
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20383
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
Cytoplasm
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20382
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
nucleoplasm
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20381
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
nucleolus
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20374
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
plays_a_role_in
→
Object:
polymerase_I_transcription
(Transcription process)
Original: Nucleolin (NCL)#plays a role in#polymerase I transcription
#20344
high Confidence
Subject:
NCL
(Nucleolin)
→
translocates_to_surface_during
→
Object:
carcinogenesis
(Tumor development process)
Original: translocation of nucleolin to cell surface#occurs during#carcinogenesis
#20343
high Confidence
Subject:
NCL
(Nucleolin)
→
is_present_on
→
Object:
surface_of_gastric_cancer_cells
(Cell subtype)
Original: nucleolin#is present on#surface of gastric cancer cell lines
#20342
high Confidence
Subject:
NCL
(Nucleolin)
→
is
→
Object:
major_component_of_silver-stained_nucleolar_organizer_region
(Molecular complex)
Original: nucleolin#is#a major component of silver-stained nucleolar organizer region and a marker of cancer
#20032
high Confidence
Subject:
NCL
(Nucleolin)
→
is_marker_of
→
Object:
cancer
(Disease phenotype)
Original: nucleolin#is#a major component of silver-stained nucleolar organizer region and a marker of cancer
#19889
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
is_overexpressed_in
→
Object:
highly_proliferative_cells
(Cell Type)
Original: Nucleolin#is over-expressed in#highly proliferative cells
#19881
middle Confidence
Subject:
miR-15a/16
(miRNA)
→
is_directly_correlated_to
→
Object:
nucleolin_expression
(Protein expression)
Original: miR-15a/16 levels#are directly correlated to#nucleolin expression
#19500
middle Confidence
Subject:
Nucleolin_high
(Protein expression status)
→
is_associated_with
→
Object:
longer_overall_survival
(Survival)
Original: Nucleolin-high PDAs#are associated with#longer median overall survival
#19053
middle Confidence
Subject:
NCL_lactylation
(Protein modification)
→
promotes
→
Object:
proliferation_of_iCCA_cells
(Cellular Processes)
Original: Nucleolin lactylation#promotes#proliferation of iCCA cells
#19052
middle Confidence
Subject:
Glycolysis
(Metabolic pathways)
→
promotes
→
Object:
P300_catalyzed_lactylation_of_NCL
(Protein modification)
Original: Glycolysis#promotes#P300-catalyzed lactylation of nucleolin
#19033
middle Confidence
Subject:
NCL
(Ribonucleoprotein)
→
impairs
→
Object:
processing_of_miR-15a/16
(miRNA processing events)
Original: Absence of nucleolin#impairs#processing of miR-15a/16 in vitro
#18666
middle Confidence
Subject:
Nucleolin
(RNA binding proteins)
→
participates_in
→
Object:
RNA_regulatory_mechanisms
(Molecular Process)
Original: Nucleolin#participates in#DNA metabolism and RNA regulatory mechanisms
#18665
middle Confidence
Subject:
Nucleolin
(RNA binding proteins)
→
participates_in
→
Object:
DNA_metabolism
(Molecular Process)
Original: Nucleolin#participates in#DNA metabolism and RNA regulatory mechanisms
#18664
middle Confidence
Subject:
Nucleolin
(RNA binding proteins)
→
binds_to
→
Object:
Drosha
(Endonuclease)
Original: Nucleolin#directly interacts with#DGCR8 and Drosha in nucleus
#18663
middle Confidence
Subject:
Nucleolin
(RNA binding proteins)
→
binds_to
→
Object:
DGCR8
(RNA binding proteins)
Original: Nucleolin#directly interacts with#DGCR8 and Drosha in nucleus
#18071
middle Confidence
Subject:
Nucleolin_expression
(Protein expression status)
→
is_prognostic_factor_for
→
Object:
overall_survival
(Survival)
Original: Nucleolin expression#is a prognostic factor for#overall survival in stage II PDA
#18070
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
is_upregulated_in
→
Object:
ductal_epithelial_cell
(Epithelial cells)
Original: Nucleolin expression#was higher in#PDAs and PDA cell lines than in nonneoplastic ductal epithelial cells
#18069
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
is_upregulated_in
→
Object:
PDA_cell_line
(Tumor cell lines)
Original: Nucleolin expression#was higher in#PDAs and PDA cell lines than in nonneoplastic ductal epithelial cells
#18068
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
is_upregulated_in
→
Object:
PDA
(Tumor type)
Original: Nucleolin expression#was higher in#PDAs and PDA cell lines than in nonneoplastic ductal epithelial cells
#17215
middle Confidence
Subject:
NCL
(Ribosomal proteins)
→
acts_as_receptor_for
→
Object:
Tipalpha
(Bacterial toxin protein)
Original: Nucleolin#acts as#a receptor for Tipalpha in mouse gastric cancer cells
#17056
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
modifies
→
Object:
nucleolus_shape_and_structure
(Subcellular structure)
Original: Depletion of nucleolin#modifies#the shape and structure of the nucleolus
#17047
middle Confidence
Subject:
KRAS4B
(Small GTPases)
→
localization_is_downregulated_by
→
Object:
Nucleolin
(Ribosomal proteins)
Original: Nucleolin knockdown#eliminates#nucleolar localization of K-Ras4B
#17046
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
knockdown_eliminates
→
Object:
nucleolar_localization_of_KRAS4B
(Protein localization process)
Original: Nucleolin knockdown#eliminates#nucleolar localization of K-Ras4B
#17027
middle Confidence
Subject:
NS1
(Viral Protein)
→
induces
→
Object:
nucleolar_stress
(Cellular stress process)
Original: Non-structural protein 1 of H3N2 influenza A virus#induces#nucleolar stress via interaction with nucleolin
#17026
middle Confidence
Subject:
NS1
(Viral Protein)
→
interacts_with
→
Object:
NCL
(Ribosome-associated proteins)
Original: Non-structural protein 1 of H3N2 influenza A virus#induces#nucleolar stress via interaction with nucleolin
#16893
middle Confidence
Subject:
EP300
(Histone acetyltransferase)
→
mediates
→
Object:
lactylation_of_NCL
(Protein modification)
Original: Nucleolin#is lactylated at#lysine 477 by P300
#16875
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
serves_as
→
Object:
binding_protein_for_ligands_involved_in_angiogenesis
(Ligand Binding Protein)
Original: Nucleolin#serves as#a binding protein for ligands implicated in proliferation/ differentiation/ adhesion/ mitogenesis/ and angiogenesis
#16874
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
serves_as
→
Object:
binding_protein_for_ligands_involved_in_mitogenesis
(Ligand Binding Protein)
Original: Nucleolin#serves as#a binding protein for ligands implicated in proliferation/ differentiation/ adhesion/ mitogenesis/ and angiogenesis
#16873
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
serves_as
→
Object:
binding_protein_for_ligands_involved_in_adhesion
(Ligand Binding Protein)
Original: Nucleolin#serves as#a binding protein for ligands implicated in proliferation/ differentiation/ adhesion/ mitogenesis/ and angiogenesis
#16872
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
serves_as
→
Object:
binding_protein_for_ligands_involved_in_differentiation
(Ligand Binding Protein)
Original: Nucleolin#serves as#a binding protein for ligands implicated in proliferation/ differentiation/ adhesion/ mitogenesis/ and angiogenesis
#16871
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
serves_as
→
Object:
binding_protein_for_ligands_involved_in_proliferation
(Ligand Binding Protein)
Original: Nucleolin#serves as#a binding protein for ligands implicated in proliferation/ differentiation/ adhesion/ mitogenesis/ and angiogenesis
#16870
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
is_expressed_on
→
Object:
cell_surface
(Cell membrane)
Original: Nucleolin#is expressed on#the cell surface
#16820
middle Confidence
Subject:
PTEN
(Protein coding genes)
→
Dephosphorylates
→
Object:
nucleolin
(protein)
Original: PTEN�?localizes in#the nucleolus and dephosphorylates nucleolin
#14649
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
is_overexpressed_in
→
Object:
rapidly_dividing_cells
(Cell Type)
Original: Nucleolin#is overexpressed in#rapidly dividing cells
#12715
middle Confidence
Subject:
p34cdc2_kinase
(Protein kinase)
→
regulates
→
Object:
Nucleolin
(Ribosome-associated proteins)
Original: Nucleolin#is under control of#p34cdc2 kinase
#12714
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
Controls
→
Object:
rDNA_transcription
(Transcription process)
Original: Nucleolin#controls#rDNA transcription
#12610
middle Confidence
Subject:
LSC
(Laser Scanning Cytometer)
→
measures
→
Object:
nucleolin_expression
(Protein expression)
Original: Laser scanning cytometer (LSC)#analyzes#nucleoli and measures expression of nucleolar protein nucleolin (NCL)
#12476
middle Confidence
Subject:
nucleolin_mutant
(Protein mutants)
→
shows
→
Object:
redundant_function_in_nucleolar_shape
(Functional redundancy)
Original: Mutants of nucleolin#show#redundant functions in transcription/ rRNA maturation/ and nucleolar shape
#12475
middle Confidence
Subject:
nucleolin_mutant
(Protein mutants)
→
shows
→
Object:
redundant_function_in_rRNA_maturation
(Functional redundancy)
Original: Mutants of nucleolin#show#redundant functions in transcription/ rRNA maturation/ and nucleolar shape
#12474
middle Confidence
Subject:
nucleolin_mutant
(Protein mutants)
→
shows
→
Object:
redundant_function_in_transcription
(Functional redundancy)
Original: Mutants of nucleolin#show#redundant functions in transcription/ rRNA maturation/ and nucleolar shape
#12473
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
depletion
→
Object:
pre-rRNA_processing
(rRNA processing)
Original: Depletion of nucleolin#slightly affects#pre-rRNA processing
#12472
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
redistributes_to
→
Object:
nucleoplasm
(Subcellular structure)
Original: DeltaAg and nucleolin#redistribute#to the nucleoplasm under cell stress
#12471
middle Confidence
Subject:
DeltaAg
(Viral Protein)
→
redistributes
→
Object:
nucleolin
(Ribosomal proteins)
Original: DeltaAg and nucleolin#redistribute#to the nucleoplasm under cell stress
#12452
middle Confidence
Subject:
disruption_of_NS1_NCL_interaction
(Experimental operation)
→
restores
→
Object:
RNA_Pol_I_dependent_transcription
(Transcription process)
Original: Disruption of NS1-nucleolin interaction#revived#RNA Pol I-dependent transcription
#12451
middle Confidence
Subject:
NS1
(Viral Protein)
→
binds_to
→
Object:
NCL
(Ribosome-associated proteins)
Original: Disruption of NS1-nucleolin interaction#revived#RNA Pol I-dependent transcription
#12301
middle Confidence
Subject:
lactate
(Metabolites)
→
is_generated_by
→
Object:
Glycolysis
(Metabolic pathways)
Original: Glycolysis#promotes#P300-catalyzed lactylation of nucleolin
#12300
middle Confidence
Subject:
NCL
(Ribosomal proteins)
→
is_lactylated_at
→
Object:
lysine_477
(Amino acid position)
Original: Nucleolin#is lactylated at#lysine 477 by P300
#12182
middle Confidence
Subject:
PTEN
(Protein coding genes)
→
localizes_in
→
Object:
nucleolus
(Organelles)
Original: PTEN�?localizes in#the nucleolus and dephosphorylates nucleolin
#12159
middle Confidence
Subject:
PES1
(Nucleolar proteins)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12158
middle Confidence
Subject:
GPC2
(Glycoprotein)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12157
middle Confidence
Subject:
NPM1
(Ribosomal proteins)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12156
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12133
middle Confidence
Subject:
nucleophosmin
(Ribosomal proteins)
→
is_associated_with
→
Object:
interphase_AgNORs
(Nucleolus-related organic silver reactants)
Original: Nucleolin and nucleophosmin#are associated with#interphase AgNORs
#12132
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
is_associated_with
→
Object:
interphase_AgNORs
(Nucleolus-related organic silver reactants)
Original: Nucleolin and nucleophosmin#are associated with#interphase AgNORs
#11553
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
acts_as
→
Object:
signaling_molecule
(signaling molecule)
Original: Nucleolin#is used as#a signaling molecule to initiate inhibitory responses
#11237
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
plays_essential_role_in
→
Object:
cell_survival
(Cellular Processes)
Original: Nucleolin#plays#an essential role in cell proliferation and survival
#11236
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
plays_essential_role_in
→
Object:
cell_proliferation
(Cellular Processes)
Original: Nucleolin#plays#an essential role in cell proliferation and survival
#10748
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
is_characterized_by
→
Object:
nucleolar-like_nuclear_appearance
(Nuclear morphology)
Original: Nucleolin#is characterized by#a nucleolar-like nuclear appearance
#8593
middle Confidence
Subject:
PDA_cell_line
(Cell lines)
→
shows
→
Object:
nucleolar_staining_for_nucleolin
(Protein localization)
Original: PDAs and PDA cell lines#showed#nucleolar staining for nucleolin
#8592
middle Confidence
Subject:
PDA
(Tumor type)
→
shows
→
Object:
nucleolar_staining_for_nucleolin
(Protein localization)
Original: PDAs and PDA cell lines#showed#nucleolar staining for nucleolin
#8591
middle Confidence
Subject:
Nucleolin_expression
(Protein expression)
→
is_evaluated_by
→
Object:
Immunohistochemistry
(Detection Technology)
Original: Nucleolin expression#was evaluated by#immunohistochemistry
#6629
middle Confidence
Subject:
LSC
(Laser Scanning Cytometer)
→
analyzes
→
Object:
nucleoli
(Cellular substructure)
Original: Laser scanning cytometer (LSC)#analyzes#nucleoli and measures expression of nucleolar protein nucleolin (NCL)
#6615
middle Confidence
Subject:
NPM_mutation
(Gene mutation)
→
impacts
→
Object:
interaction_with_nucleolin
(Protein Interactions)
Original: NPM mutation#impacts#interaction with nucleolin (NCL) in nucleolus
#6439
middle Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_localized_in
→
Object:
cell_membrane
(Cell membrane)
Original: Nucleolin#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#6438
middle Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_localized_in
→
Object:
Cytoplasm
(Cell compartment)
Original: Nucleolin#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#6437
middle Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_localized_in
→
Object:
nucleoplasm
(Organelles)
Original: Nucleolin#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#6436
middle Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_localized_in
→
Object:
nucleolus
(Organelles)
Original: Nucleolin#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#6376
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
redistribution_precedes
→
Object:
histone_phosphorylation_decrease
(Epigenetic modification)
Original: redistribution of nucleolin#precedes#decrease of histone acetylation and phosphorylation
#6375
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
redistribution_precedes
→
Object:
histone_acetylation_decrease
(Epigenetic modification)
Original: redistribution of nucleolin#precedes#decrease of histone acetylation and phosphorylation
#6374
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
redistributes_from
→
Object:
nucleolus
(Cellular substructure)
Original: nucleolin#redistributes from#nucleolus after 6 hours
#4382
low Confidence
Subject:
Nucleolin_expression
(Protein expression)
→
is_classified_as
→
Object:
nucleolin-low
(Expression typing)
Original: Nucleolin expression#was classified as#nucleolin-high or nucleolin-low
#4381
low Confidence
Subject:
Nucleolin_expression
(Protein expression)
→
is_classified_as
→
Object:
nucleolin-high
(Expression typing)
Original: Nucleolin expression#was classified as#nucleolin-high or nucleolin-low
#3941
low Confidence
Subject:
nucleolin_expression
(Protein expression)
→
has_no_significant_correlation_with
→
Object:
clinicopathologic_parameters
(Clinical parameters)
Original: Nucleolin expression#has no significant correlation with#clinicopathologic parameters
#734
low Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
coordinately_controlled_with
→
Object:
RRP1
(Ribosomal proteins)
Original: Expression of nucleolin and NO38#is controlled#coordinately