List of serched triples

A total of 22252 records found

#21612 high Confidence
Subject: H2AX (Histone variants)
is_upregulated_in
Object: irradiated_genome (Damaged genome)
Original: Increased levels of H2AX and 53BP1 proteins#were confirmed in#irradiated genome
🏥 not_specified 🧬 H2AX/TP53BP1 📄 PMID: 25369346
#21611 high Confidence
Subject: Ki-67 Antibody (Antibody)
are_used_as
Object: prognostic_tools (Diagnostic Tools)
Original: Antibodies against Ki-67 protein#are used as#prognostic tools in cancer patient biopsies
🏥 Prognostic value 🧬 MKI67 📄 PMID: 17531085
#21610 high Confidence
Subject: p53 (Transcription Factors)
leads_to
Object: apoptosis (Apoptosis)
Original: Accumulation of p53#leads to#cell cycle arrest or apoptosis
🏥 Therapeutic significance 🧬 TP53 📄 PMID: 21471221
#21609 high Confidence
Subject: p53 (Transcription Factors)
leads_to
Object: cell_cycle_arrest (Cell cycle arrest)
Original: Accumulation of p53#leads to#cell cycle arrest or apoptosis
🏥 Therapeutic significance 🧬 TP53 📄 PMID: 21471221
#21608 high Confidence
Subject: PML (Tumor suppressor proteins)
sequesters
Object: MDM2_to_nucleolus (Protein localization)
Original: PML#sequesters#Mdm2 to the nucleolus
🏥 not_specified 🧬 PML/MDM2 📄 PMID: 15195100
#21607 high Confidence
Subject: PML (Tumor suppressor proteins)
interacts_with
Object: MDM2 (Ubiquitin ligase)
Original: PML#interacts with#p53 ubiquitin-ligase Mdm2
🏥 not_specified 🧬 PML/MDM2 📄 PMID: 15195100
#21606 high Confidence
Subject: TP53 (Transcription Factors)
is_a
Object: nucleocytoplasmic_shuttling_protein (Protein function)
Original: Tumor suppressor p53#is a#nucleocytoplasmic shuttling protein
🏥 not_specified 🧬 TP53 📄 PMID: 11329373
#21605 high Confidence
Subject: MMP2 (Protease)
regulates
Object: cell_proliferation (Cellular Processes)
Original: Matrix metalloproteinase-2#regulates#cell proliferation through histone clipping and facilitation of ribosomal RNA transcription
🏥 not_specified 🧬 MMP2 📄 PMID: 34101354
#21604 high Confidence
Subject: ribosomal_RNA_genes (Genomic DNA sequence)
are_located_in
Object: nucleolus (Cellular substructure)
Original: Genes encoding ribosomal RNA#are located in#the nucleolus
🏥 not_specified 📄 PMID: 34101354
#21603 high Confidence
Subject: Nucleic_acid_binding_domains (Protein domain)
are_targeted_by
Object: autoantibodies_in_SLE (Autoantibodies)
Original: Nucleic acid-binding domains#are targeted by#autoantibodies in SLE
🏥 Diagnostic significance 📄 PMID: 7545391
#21602 high Confidence
Subject: Topo_I_N-terminal_domain (Protein domain)
is_fused_to
Object: EGFP (Fluorescent Protein)
Original: Topo I N-terminal domain#is fused to#enhanced green fluorescent protein (EGFP)
🏥 not_specified 📄 PMID: 11805286
#21601 high Confidence
Subject: NPM_C-terminal_mutation (Gene mutation)
is_associated_with
Object: better_outcome_of_AML_therapy (Clinical Outcomes)
Original: Mutations in C-terminal part of NPM#are associated with#better outcome of AML therapy
🏥 Prognosis 🧬 NPM 📄 PMID: 26505272
#21600 high Confidence
Subject: nucleolar_number (Cellular substructure)
is_recognized_as
Object: tumor_hallmark (Disease phenotype)
Original: Larger nucleolar size and number#are recognized as#hallmark features of many tumor types
🏥 Diagnostic significance 📄 PMID: 26721423
#21599 high Confidence
Subject: nucleolar_size (Cellular substructure)
is_recognized_as
Object: tumor_hallmark (Disease phenotype)
Original: Larger nucleolar size and number#are recognized as#hallmark features of many tumor types
🏥 Diagnostic significance 📄 PMID: 26721423
#21598 high Confidence
Subject: microRNAs (MicroRNA)
play_key_roles_in
Object: tumor_biology (Tumor Biology)
Original: microRNAs (miRNAs)#play#key roles in development/ cell proliferation/ apoptosis/ and tumor biology
🏥 not_specified 📄 PMID: 23276918
#21597 high Confidence
Subject: microRNAs (MicroRNA)
play_key_roles_in
Object: apoptosis (Apoptosis)
Original: microRNAs (miRNAs)#play#key roles in development/ cell proliferation/ apoptosis/ and tumor biology
🏥 not_specified 📄 PMID: 23276918
#21596 high Confidence
Subject: microRNAs (MicroRNA)
play_key_roles_in
Object: cell_proliferation (Cell proliferation)
Original: microRNAs (miRNAs)#play#key roles in development/ cell proliferation/ apoptosis/ and tumor biology
🏥 not_specified 📄 PMID: 23276918
#21595 high Confidence
Subject: microRNAs (MicroRNA)
play_key_roles_in
Object: development (Developmental process)
Original: microRNAs (miRNAs)#play#key roles in development/ cell proliferation/ apoptosis/ and tumor biology
🏥 not_specified 📄 PMID: 23276918
#21594 high Confidence
Subject: nucleolar_organizer_regions (Nucleolar organizing region)
contain
Object: nonhistone_proteins (Non-histone proteins)
Original: nucleolar organizer regions#contain#nonhistone proteins
🏥 not_specified 📄 PMID: 9836854
#21593 high Confidence
Subject: nucleolus (Organelles)
fulfills
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: nucleolus#fulfills#crucial functions in ribosome biogenesis
🏥 not_specified 📄 PMID: 32640701