List of serched triples

A total of 22252 records found

#21592 high Confidence
Subject: ALK_phosphorylation (Protein kinase modification)
drives
Object: systemic_ALCL_pathogenesis (Disease progression)
Original: Phosphorylation of ALK tyrosine kinase#drives#systemic ALCL pathogenesis
🏥 treat 🧬 ALK 📄 PMID: 12876673
#21591 high Confidence
Subject: rRNA_biogenesis (Molecular Process)
activates
Object: p53 (Tumor suppressor proteins)
Original: Disruption of rRNA biogenesis#activates#p53 by release of ribosomal proteins from nucleoli
🏥 not_specified 🧬 TP53/MDM2 📄 PMID: 17110929
#21590 high Confidence
Subject: DCAF13 (Ubiquitin ligase)
enhances
Object: cell_proliferation (Cell proliferation)
Original: DCAF13#enhances#Pol I transcription and proliferation in BC cells
🏥 Tumor progression 🧬 DCAF13/POLR1A 📄 PMID: 39788980
#21589 high Confidence
Subject: DCAF13 (Ubiquitin ligase)
enhances
Object: Pol_I_transcription (Transcriptional activity)
Original: DCAF13#enhances#Pol I transcription and proliferation in BC cells
🏥 not_specified 🧬 DCAF13/POLR1A 📄 PMID: 39788980
#21588 high Confidence
Subject: assembly_and_maturation_factors (Ribosome assembly factor)
are_upregulated_in
Object: Breast_Cancer (disease)
Original: Assembly and maturation factors (AMFs)#are upregulated in#Breast Cancer
🏥 Tumor progression 📄 PMID: 39788980
#21587 high Confidence
Subject: K63-linked_ubiquitination_of_POLR1A (Protein modification)
promotes
Object: uncontrolled_proliferation (Cell proliferation)
Original: DCAF13-mediated K63-linked ubiquitination of RNA polymerase I#promotes#uncontrolled proliferation in Breast Cancer
🏥 Tumor progression 🧬 DCAF13/POLR1A 📄 PMID: 39788980
#21586 high Confidence
Subject: DCAF13 (Ubiquitin ligase)
mediates
Object: K63-linked_ubiquitination_of_POLR1A (Protein modification)
Original: DCAF13-mediated K63-linked ubiquitination of RNA polymerase I#promotes#uncontrolled proliferation in Breast Cancer
🏥 not_specified 🧬 DCAF13/POLR1A 📄 PMID: 39788980
#21585 high Confidence
Subject: c-Myc (Transcription Factors)
regulates
Object: cell_proliferation (Cell proliferation)
Original: c-Myc#regulates#ribosomal RNA synthesis/ ribosome biogenesis/ and cell proliferation
🏥 not_specified 🧬 MYC 📄 PMID: 24481446
#21584 high Confidence
Subject: c-Myc (Transcription Factors)
regulates
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: c-Myc#regulates#ribosomal RNA synthesis/ ribosome biogenesis/ and cell proliferation
🏥 not_specified 🧬 MYC 📄 PMID: 24481446
#21583 high Confidence
Subject: c-Myc (Transcription Factors)
regulates
Object: ribosomal_RNA_synthesis (Ribosomal RNA synthesis)
Original: c-Myc#regulates#ribosomal RNA synthesis/ ribosome biogenesis/ and cell proliferation
🏥 not_specified 🧬 MYC 📄 PMID: 24481446
#21582 high Confidence
Subject: ECT2 (Guanine nucleotide exchange factor)
promotes
Object: cancer_cell_proliferation (Cell proliferation)
Original: ECT2#promotes#cancer cell proliferation
🏥 Therapeutic/prognostic significance 🧬 ECT2 📄 PMID: 32350115
#21581 high Confidence
Subject: miRNA (Noncoding RNA)
undergoes
Object: multistep_biogenesis (RNA biosynthesis process)
Original: MicroRNAs (miRNA)#undergo#a multistep biogenesis
🏥 not_specified 🧬 miRNA 📄 PMID: 22049078
#21580 high Confidence
Subject: FBL (Ribosome biogenesis protein)
sensitizes
Object: tumor_cells_to_DNA_crosslinking_agents (Cellular drug sensitivity)
Original: Knockdown of FBL#sensitizes#tumor cells to DNA crosslinking agents
🏥 Treatment related 🧬 FBL 📄 PMID: 37489617
#21579 high Confidence
Subject: Fibrillarin (Methyltransferase)
is_responsible_for
Object: methylation_of_ribosomal_RNA (Molecular modification)
Original: Fibrillarin (FBL)#is responsible for#methylation of ribosomal RNA and proteins
🏥 not_specified 🧬 FBL 📄 PMID: 37489617
#21578 high Confidence
Subject: ribosomal_stress (Cellular stress)
triggers
Object: p53_signaling_pathway_activation (Signaling pathway activation)
Original: Ribosomal stress#triggers#p53 signaling pathway activation via RPs-MDM2 interactions
🏥 not_specified 🧬 RPs/MDM2/TP53 📄 PMID: 25164622
#21577 high Confidence
Subject: Ribosomal_proteins (Ribosomal proteins)
activates
Object: p53 (Transcription Factors)
Original: Ribosomal proteins (RPs)#activate#p53 tumor-suppressor protein upon nucleolus disruption
🏥 not_specified 🧬 RPs/TP53 📄 PMID: 22081073
#21576 high Confidence
Subject: nucleolus (Subcellular structure)
is_involved_in
Object: ribosome_biogenesis (Molecular Process)
Original: The nucleolus#is involved in#ribosomal RNA synthesis/ ribosome biogenesis/ and stress response
🏥 not_specified 📄 PMID: 35325178
#21575 high Confidence
Subject: nucleolus (Subcellular structure)
is_involved_in
Object: ribosomal_RNA_synthesis (Molecular Process)
Original: The nucleolus#is involved in#ribosomal RNA synthesis/ ribosome biogenesis/ and stress response
🏥 not_specified 📄 PMID: 35325178
#21574 high Confidence
Subject: nucleolus (Subcellular structure)
is
Object: nuclear_subcompartment_for_ribosome_subunit_biogenesis (Subcellular structure function)
Original: Nucleolus#is#a nuclear subcompartment for rRNA production and ribosome subunit biogenesis
🏥 not_specified 📄 PMID: 27416361
#21573 high Confidence
Subject: nucleolus (Subcellular structure)
is
Object: nuclear_subcompartment_for_rRNA_production (Subcellular structure function)
Original: Nucleolus#is#a nuclear subcompartment for rRNA production and ribosome subunit biogenesis
🏥 not_specified 📄 PMID: 27416361