List of serched triples

A total of 22252 records found

#21652 high Confidence
Subject: NPM1 (Nucleolar proteins)
facilitates
Object: ribosome_biogenesis (Molecular complex synthesis)
Original: NPM1#facilitates#ribosome biogenesis and nucleolar stress responses
🏥 not_specified 🧬 NPM1 📄 PMID: 39528457
#21651 high Confidence
Subject: Ribosome_biogenesis (Biological Process)
is_initiated_in
Object: nucleolus (Cellular substructure)
Original: Ribosome biogenesis#is initiated in#nucleolus
🏥 not_specified 📄 PMID: 27265389
#21650 high Confidence
Subject: nucleolus (Subcellular structure)
is_involved_in
Object: ribosome_subunit_biogenesis (Molecular Process)
Original: Nucleolus#is involved in#ribosome subunit biogenesis/ cell cycle control/ and stress responses
🏥 not_specified 📄 PMID: 16819967
#21649 high Confidence
Subject: K562_cells (Cell lines)
carry
Object: bcr/abl_fusion_gene (Fusion gene)
Original: K562 cells#carry#bcr/abl fusion gene
🏥 not_specified 🧬 BCR/ABL 📄 PMID: 15507844
#21648 high Confidence
Subject: risk_signature (Risk Scoring Model)
has
Object: independent_prognostic_significance (Clinical Outcomes)
Original: Risk signature#has#independent prognostic significance for HGSOC
🏥 Prognostic significance 📄 PMID: 37395023
#21647 high Confidence
Subject: DEN_exposure (Environmental carcinogens)
induces
Object: neoplasms (Tumor)
Original: DEN exposure#induces#altered foci and neoplasms in fish
🏥 Tumorigenesis 🧬 RAS/MYC/FOS/TP53/EGFR 📄 PMID: 7923595
#21646 high Confidence
Subject: DEN_exposure (Environmental carcinogens)
induces
Object: altered_foci (Pathological morphology)
Original: DEN exposure#induces#altered foci and neoplasms in fish
🏥 Tumorigenesis 🧬 RAS/MYC/FOS/TP53/EGFR 📄 PMID: 7923595
#21645 high Confidence
Subject: RNA_polymerase_I (Enzymes)
is_a_target_of
Object: novel_drugs (Small molecule drugs)
Original: Novel drugs targeting RNA Polymerase I#are#viable targets for cancer therapies
🏥 Therapeutic targets 🧬 POLR1A 📄 PMID: 33805424
#21644 high Confidence
Subject: mTOR_pathway_proteins (Signaling pathway proteins)
are_activated_in
Object: ductal_adenocarcinoma (Tumor type)
Original: mTOR pathway proteins#are activated in#ductal adenocarcinoma
🏥 Therapeutic significance 🧬 MTOR 📄 PMID: 24040460
#21643 high Confidence
Subject: MYB (Protein coding genes)
fusion_and_expression_correlate_with
Object: predictors_of_outcome (Clinical prognostic indicators)
Original: MYB fusion and protein expression#were correlated with#predictors of outcome in adenoid cystic carcinoma
🏥 Prognostic significance 🧬 MYB 📄 PMID: 28719465
#21642 high Confidence
Subject: MYC (Protein coding genes)
amplification_correlates_with
Object: overexpression_of_MYC (Protein expression)
Original: C-MYC amplification#was correlated with#overexpression of C-MYC/ TERT/ and FBL
🏥 Diagnostic/prognostic significance 🧬 MYC/TERT/FBL 📄 PMID: 12950019
#21641 high Confidence
Subject: SDHB (Protein coding genes)
involved_in
Object: SDH_deficient_RCC (Disease phenotype)
Original: Gene alterations#involve#SDHB subunit in SDH-deficient RCC
🏥 Diagnostic significance 🧬 SDHB 📄 PMID: 39083879
#21640 high Confidence
Subject: NPM1 (Protein coding genes)
mutated_leads_to
Object: aberrant_cytoplasmic_dislocation_of_NPM-c (Abnormal protein localization)
Original: Mutations in NPM1#lead to#aberrant cytoplasmic dislocation of NPM-c
🏥 not_specified 🧬 NPM1 📄 PMID: 20699639
#21639 high Confidence
Subject: MKI67 (Cell proliferation marker protein)
is_upregulated
Object: PHE_tissues (Tissue samples)
Original: Proliferation index of Ki-67#is#10-35%
🏥 Diagnostic significance 🧬 MKI67 📄 PMID: 36803395
#21638 high Confidence
Subject: FGF2 (Growth factor protein)
is_expressed_in
Object: gliomas (Tumor tissue)
Original: Basic FGF mRNA#is expressed in#more than 90% of human gliomas
🏥 Diagnostic significance 🧬 FGF2 📄 PMID: 1564542
#21637 high Confidence
Subject: EGFR (Receptor protein)
inhibition_of
Object: tumor_growth (Tumor growth process)
Original: Reduction in EGF receptors#inhibits#tumor growth
🏥 treat 🧬 EGF 📄 PMID: 10480336
#21636 high Confidence
Subject: NPM1c+_variant (Protein coding gene mutants)
causes
Object: cytoplasmic_accumulation_of_APE1 (Abnormal molecular localization)
Original: Expression of NPM1c+ variant#causes#cytoplasmic accumulation of APE1 in HeLa cells/ OCI/AML3 cells/ and primary lymphoblasts
🏥 Pathogenic mechanism 🧬 NPM1/APE1 📄 PMID: 23831574
#21635 high Confidence
Subject: MYC (Protein coding genes)
amplified_in
Object: chromatin_remodeling_pathway (signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
🏥 Pathogenic mechanism 🧬 ATM/BRCA1/BRCA2/ARID1A/DICER1/SMAD4/NOTCH1/MYC 📄 PMID: 39450999
#21634 high Confidence
Subject: NOTCH1 (Protein coding genes)
mutated_in
Object: chromatin_remodeling_pathway (signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
🏥 Pathogenic mechanism 🧬 ATM/BRCA1/BRCA2/ARID1A/DICER1/SMAD4/NOTCH1/MYC 📄 PMID: 39450999
#21633 high Confidence
Subject: SMAD4 (Protein coding genes)
mutated_in
Object: chromatin_remodeling_pathway (signaling pathway)
Original: Mutations in ATM/ BRCA1/ BRCA2/ ARID1A/ DICER1/ SMAD4/ NOTCH1/ and MYC amplification#were identified in#DNA damage repair and chromatin remodeling pathways in CCAs
🏥 Pathogenic mechanism 🧬 ATM/BRCA1/BRCA2/ARID1A/DICER1/SMAD4/NOTCH1/MYC 📄 PMID: 39450999