List of serched triples

A total of 22252 records found

#21572 high Confidence
Subject: puromycin_aminonucleoside (Small molecule drugs)
selectively_inhibits
Object: ribosomal_RNA_synthesis (rRNA synthesis)
Original: Puromycin aminonucleoside#selectively inhibits#synthesis of ribosomal RNA
🏥 not_specified 📄 PMID: 457784
#21571 high Confidence
Subject: nucleolus (Organelles)
is_responsible_for
Object: ribosomal_subunit_transcription (Ribosomal subunit transcription)
Original: Nucleolus#is responsible for#transcription and assembly of ribosome subunits
🏥 not_specified 📄 PMID: 23636076
#21570 high Confidence
Subject: NCL (Ribosome-associated proteins)
is_involved_in
Object: cell_proliferation (Cell proliferation)
Original: NCL#is involved in#cell proliferation
🏥 not_specified 🧬 NCL 📄 PMID: 28751161
#21569 high Confidence
Subject: NCL (Ribosome-associated proteins)
is_involved_in
Object: ribosome_biogenesis (Ribosome biogenesis)
Original: NCL#is involved in#ribosome biogenesis
🏥 not_specified 🧬 NCL 📄 PMID: 28751161
#21568 high Confidence
Subject: Niraparib (PARP inhibitors)
inhibits
Object: PARP1-mediated_ADPRylation_of_DDX21 (Protein modification)
Original: Inhibition of PARP1-mediated ADPRylation of DDX21 by niraparib#mislocalizes#DDX21 to nucleoplasm
🏥 Treatment Mechanism 🧬 DDX21 📄 PMID: 38767454
#21567 high Confidence
Subject: CX5461 (Small molecule inhibitors)
targets
Object: RNAPOL1 (RNA polymerase)
Original: CX5461#disrupts#nucleolar integrity by targeting RNAPOL1
🏥 Treatment Mechanism 🧬 POLR1 📄 PMID: 35673898
#21566 high Confidence
Subject: MDM2 (Ubiquitin ligase)
binds_to
Object: RPL11 (Ribosomal proteins)
Original: RPL11#binds#MDM2 to centralize the nucleolar stress-sensing pathway
🏥 not_specified 🧬 RPL11/MDM2 📄 PMID: 36071402
#21565 high Confidence
Subject: RPL11 (Ribosomal proteins)
binds_to
Object: MDM2 (Ubiquitin ligase)
Original: RPL11#binds#MDM2 to centralize the nucleolar stress-sensing pathway
🏥 not_specified 🧬 RPL11/MDM2 📄 PMID: 36071402
#21564 high Confidence
Subject: ribosome_biogenesis (Ribosome biogenesis)
disruption_kills
Object: tumor_cells (cancer cell)
Original: Disruption of ribosome biogenesis#kills#tumor cells via nucleolar function disruption
🏥 treat 🧬 TP53 📄 PMID: 25464032
#21563 high Confidence
Subject: cancer_cells (cancer cell)
exhibit
Object: increased_ribosome_biogenesis (Ribosome biogenesis)
Original: Cancer cells#exhibit#large nucleoli and increased ribosome biogenesis
🏥 Tumor characteristics 📄 PMID: 26206377
#21562 high Confidence
Subject: cancer_cells (cancer cell)
exhibit
Object: large_nucleoli (Cellular substructure)
Original: Cancer cells#exhibit#large nucleoli and increased ribosome biogenesis
🏥 Tumor characteristics 📄 PMID: 26206377
#21561 high Confidence
Subject: SGO2 (Protein coding genes)
is_overexpressed_in
Object: Cancer (Tumor type)
Original: SGO2#is found to be#overexpressed in 25 of 33 cancer types/ including LUAD
🏥 Diagnosis/Prognosis 🧬 SGO2 📄 PMID: 39344317
#21560 high Confidence
Subject: SGO2 (Protein coding genes)
is_overexpressed_in
Object: LUAD (Tumor type)
Original: SGO2#is found to be#overexpressed in 25 of 33 cancer types/ including LUAD
🏥 Diagnosis/Prognosis 🧬 SGO2 📄 PMID: 39344317
#21559 high Confidence
Subject: Ki-67 (Cell proliferation markers)
parallels
Object: cell_proliferation (Cellular Processes)
Original: Ki-67 expression#paralleled#cell proliferation in fibroblasts and lymphocytes
🏥 Diagnostic significance 🧬 MKI67 📄 PMID: 2476477
#21558 high Confidence
Subject: Ki-67 (Cell proliferation markers)
parallels
Object: cell_proliferation (Cellular Processes)
Original: Ki-67 expression#paralleled#cell proliferation in fibroblasts and lymphocytes
🏥 Diagnostic significance 🧬 MKI67 📄 PMID: 2476477
#21557 high Confidence
Subject: ALK (Tyrosine kinase)
is_activated_through
Object: chromosomal_translocation_with_NPM (Genomic abnormalities)
Original: ALK#is activated through#chromosomal translocations with NPM
🏥 Pathogenesis 🧬 ALK/NPM 📄 PMID: 12876673
#21556 high Confidence
Subject: AOM (Chemical carcinogens)
induces
Object: colonic_aberrant_crypt_foci (Pathological process)
Original: AOM#induced#colonic aberrant crypt foci in rats
🏥 not_specified 📄 PMID: 8071110
#21555 high Confidence
Subject: NOP16 (Ribosomal proteins)
is_primarily_expressed_in
Object: T_lymphocytes (Immune cells)
Original: LIHC scRNA-seq data#showed#NOP16 was primarily expressed in T lymphocytes
🏥 not_specified 🧬 NOP16 📄 PMID: 38251077
#21554 high Confidence
Subject: protein (protein)
is_member_of
Object: DEAD-box_family (Protein family)
Original: Protein#is a member of#DEAD-box family
🏥 not_specified 📄 PMID: 10749921
#21553 high Confidence
Subject: DHODH (Enzymes)
inhibition_depletes
Object: pyrimidine_pool (Metabolites)
Original: Pharmacological inhibition of DHODH#depleted#the pool of pyrimidines in glioblastoma cells
🏥 Treatment Mechanism 🧬 DHODH 📄 PMID: 33201894