Search results of triples
A total of 173 records found
#22119
high Confidence
Subject:
UBF
(Transcription Factors)
→
initiates
→
Object:
rRNA_transcription
(Molecular Process)
Original: Upstream binding factor (UBF)#recognizes#ribosomal RNA gene promoter and initiates transcription
#22118
high Confidence
Subject:
UBF
(Transcription Factors)
→
recognizes
→
Object:
rRNA_gene_promoter
(DNA sequence)
Original: Upstream binding factor (UBF)#recognizes#ribosomal RNA gene promoter and initiates transcription
#21620
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
involved_in
→
Object:
ribosome_assembly
(Molecular complex assembly)
Original: Fibrillarin#is involved in#pre-rRNA processing/ methylation/ and ribosome assembly
#21619
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
involved_in
→
Object:
rRNA_methylation
(Molecular modification)
Original: Fibrillarin#is involved in#pre-rRNA processing/ methylation/ and ribosome assembly
#21618
high Confidence
Subject:
Fibrillarin
(Methyltransferase)
→
involved_in
→
Object:
pre-rRNA_processing
(Molecular Process)
Original: Fibrillarin#is involved in#pre-rRNA processing/ methylation/ and ribosome assembly
#21535
high Confidence
Subject:
NCL
(Nucleolin)
→
is_promising_target_for
→
Object:
treatment_of_gastric_cancer
(Clinical treatment)
Original: nucleolin on cell surface#is a promising target for#treatment of gastric cancer
#21196
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
alpha_1_antichymotrypsin
(Protease inhibitors)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21195
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
LCA
(common leukocyte antigen)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21194
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
myoglobin
(Cytoskeletal proteins)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21193
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
NSE
(Neuron-specific enolase)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21192
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
S-100_protein
(Cytoskeletal proteins)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21191
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_negative_for
→
Object:
desmin
(Cytoskeletal proteins)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21190
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_positive_for
→
Object:
keratin
(Cytoskeletal proteins)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#21189
high Confidence
Subject:
hyaline_inclusions
(Cell structure)
→
are_positive_for
→
Object:
vimentin
(Cytoskeletal proteins)
Original: Hyaline inclusions#are positive for#vimentin and keratin/ but negative with desmin/ S-100 protein/ NSE/ myoglobin/ LCA/ alpha-1-antichymotrypsin
#20474
high Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
depletion
→
Object:
rDNA_transcription
(Transcription process)
Original: Depletion of nucleolin#inhibits#rDNA transcription
#20473
high Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
is_highly_expressed_in
→
Object:
cancer_cell_lines
(Cell Type)
Original: Nucleolin#is highly expressed in#rapidly dividing cells and cancer cell lines
#20472
high Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
is_highly_expressed_in
→
Object:
rapidly_dividing_cells
(Cell Type)
Original: Nucleolin#is highly expressed in#rapidly dividing cells and cancer cell lines
#20434
high Confidence
Subject:
nucleolus
(Nuclear structure)
→
responsible_for
→
Object:
rRNA_processing
(Process)
Original: The nucleolus#is responsible for#ribosomal RNA transcription/ processing/ and ribosome assembly
#20421
high Confidence
Subject:
Nucleolin lactylation
(Protein post-translational modification)
→
promotes
→
Object:
invasion of iCCA cells
(Cellular Processes)
Original: Nucleolin lactylation#promotes#invasion of iCCA cells
#20420
high Confidence
Subject:
NCL
(Ribosomal proteins)
→
correlates_with
→
Object:
iCCA_progression
(Disease phenotype)
Original: Nucleolin#correlates with#iCCA occurrence and progression
#20419
high Confidence
Subject:
NCL
(Ribosomal proteins)
→
correlates_with
→
Object:
iCCA_occurrence
(Disease phenotype)
Original: Nucleolin#correlates with#iCCA occurrence and progression
#20407
high Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_involved_in
→
Object:
miR-15a/16_biogenesis_primary_to_precursor
(miRNA biogenesis events)
Original: Nucleolin#is involved in#biogenesis of miR-15a/16 at primary to precursor stage
#20384
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
cell_membrane
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20383
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
Cytoplasm
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20382
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
nucleoplasm
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20381
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
is_localized_in
→
Object:
nucleolus
(Cellular substructure)
Original: Nucleolin (NCL)#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#20374
high Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
plays_a_role_in
→
Object:
polymerase_I_transcription
(Transcription process)
Original: Nucleolin (NCL)#plays a role in#polymerase I transcription
#20344
high Confidence
Subject:
NCL
(Nucleolin)
→
translocates_to_surface_during
→
Object:
carcinogenesis
(Tumor development process)
Original: translocation of nucleolin to cell surface#occurs during#carcinogenesis
#20343
high Confidence
Subject:
NCL
(Nucleolin)
→
is_present_on
→
Object:
surface_of_gastric_cancer_cells
(Cell subtype)
Original: nucleolin#is present on#surface of gastric cancer cell lines
#20342
high Confidence
Subject:
NCL
(Nucleolin)
→
is
→
Object:
major_component_of_silver-stained_nucleolar_organizer_region
(Molecular complex)
Original: nucleolin#is#a major component of silver-stained nucleolar organizer region and a marker of cancer
#20095
high Confidence
Subject:
5-azacytidine
(DNA methylation inhibitors)
→
inhibits
→
Object:
rRNA_processing
(Ribosomal RNA processing)
Original: 5-azacytidine#inhibits#rRNA processing
#20073
high Confidence
Subject:
E
(Molecular complex)
→
suppresses
→
Object:
rRNA_transcription
(rRNA transcription process)
Original: eNoSC#suppresses#rRNA transcription in response to glucose starvation
#20032
high Confidence
Subject:
NCL
(Nucleolin)
→
is_marker_of
→
Object:
cancer
(Disease phenotype)
Original: nucleolin#is#a major component of silver-stained nucleolar organizer region and a marker of cancer
#19889
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
is_overexpressed_in
→
Object:
highly_proliferative_cells
(Cell Type)
Original: Nucleolin#is over-expressed in#highly proliferative cells
#19883
middle Confidence
Subject:
NOLC1
(Nucleolus-associated protein)
→
promotes
→
Object:
rRNA_transcription
(Transcription process)
Original: NOLC1#promotes#rRNA transcription in ribosome biogenesis
#19881
middle Confidence
Subject:
miR-15a/16
(miRNA)
→
is_directly_correlated_to
→
Object:
nucleolin_expression
(Protein expression)
Original: miR-15a/16 levels#are directly correlated to#nucleolin expression
#19500
middle Confidence
Subject:
Nucleolin_high
(Protein expression status)
→
is_associated_with
→
Object:
longer_overall_survival
(Survival)
Original: Nucleolin-high PDAs#are associated with#longer median overall survival
#19115
middle Confidence
Subject:
TERF2
(Telomere binding protein)
→
promotes
→
Object:
rRNA_transcription
(rRNA transcription)
Original: Nucleolar TRF2#binds#rDNA and promotes rRNA transcription
#19053
middle Confidence
Subject:
NCL_lactylation
(Protein modification)
→
promotes
→
Object:
proliferation_of_iCCA_cells
(Cellular Processes)
Original: Nucleolin lactylation#promotes#proliferation of iCCA cells
#19052
middle Confidence
Subject:
Glycolysis
(Metabolic pathways)
→
promotes
→
Object:
P300_catalyzed_lactylation_of_NCL
(Protein modification)
Original: Glycolysis#promotes#P300-catalyzed lactylation of nucleolin
#19050
middle Confidence
Subject:
UBF1-mediated_ECT2_recruitment
(Protein complex assembly)
→
elevates
→
Object:
rRNA_synthesis
(Transcription product)
Original: UBF1-mediated ECT2 recruitment#elevates#rRNA synthesis
#19043
middle Confidence
Subject:
pseudo-uridylation_of_rRNA
(RNA modification)
→
is_necessary_for
→
Object:
rRNA_processing
(RNA processing)
Original: Pseudo-uridylation of rRNA#is necessary for#processing
#19033
middle Confidence
Subject:
NCL
(Ribonucleoprotein)
→
impairs
→
Object:
processing_of_miR-15a/16
(miRNA processing events)
Original: Absence of nucleolin#impairs#processing of miR-15a/16 in vitro
#19013
middle Confidence
Subject:
PWP1
(protein)
→
regulates
→
Object:
RNA_polymerase_I-mediated_rRNA_transcription
(Transcription process)
Original: PWP1#regulates#RNA polymerase I-mediated rRNA transcription
#18987
middle Confidence
Subject:
FBL
(Ribosomal proteins)
→
is_required_for
→
Object:
rRNA_processing
(Molecular modification regulation)
Original: FBL (encoding fibrillarin)#is required for#proliferation/ clonogenic survival/ and proper rRNA accumulation/processing in human prostate cancer cells
#18986
middle Confidence
Subject:
FBL
(Ribosomal proteins)
→
is_required_for
→
Object:
rRNA_accumulation
(Small molecule metabolites)
Original: FBL (encoding fibrillarin)#is required for#proliferation/ clonogenic survival/ and proper rRNA accumulation/processing in human prostate cancer cells
#18985
middle Confidence
Subject:
FBL
(Ribosomal proteins)
→
is_required_for
→
Object:
clonogenic_survival
(Cellular Processes)
Original: FBL (encoding fibrillarin)#is required for#proliferation/ clonogenic survival/ and proper rRNA accumulation/processing in human prostate cancer cells
#18984
middle Confidence
Subject:
FBL
(Ribosomal proteins)
→
is_required_for
→
Object:
proliferation
(Cellular Processes)
Original: FBL (encoding fibrillarin)#is required for#proliferation/ clonogenic survival/ and proper rRNA accumulation/processing in human prostate cancer cells
#18681
middle Confidence
Subject:
MDK
(protein)
→
plays_a_role_in
→
Object:
cell_proliferation
(Cellular Processes)
Original: MK#plays a role in#rRNA transcription/ ribosome biogenesis/ and cell proliferation in HepG2 cells
#18680
middle Confidence
Subject:
MDK
(protein)
→
plays_a_role_in
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: MK#plays a role in#rRNA transcription/ ribosome biogenesis/ and cell proliferation in HepG2 cells
#18679
middle Confidence
Subject:
MDK
(protein)
→
plays_a_role_in
→
Object:
rRNA_transcription
(Transcription process)
Original: MK#plays a role in#rRNA transcription/ ribosome biogenesis/ and cell proliferation in HepG2 cells
#18666
middle Confidence
Subject:
Nucleolin
(RNA binding proteins)
→
participates_in
→
Object:
RNA_regulatory_mechanisms
(Molecular Process)
Original: Nucleolin#participates in#DNA metabolism and RNA regulatory mechanisms
#18665
middle Confidence
Subject:
Nucleolin
(RNA binding proteins)
→
participates_in
→
Object:
DNA_metabolism
(Molecular Process)
Original: Nucleolin#participates in#DNA metabolism and RNA regulatory mechanisms
#18664
middle Confidence
Subject:
Nucleolin
(RNA binding proteins)
→
binds_to
→
Object:
Drosha
(Endonuclease)
Original: Nucleolin#directly interacts with#DGCR8 and Drosha in nucleus
#18663
middle Confidence
Subject:
Nucleolin
(RNA binding proteins)
→
binds_to
→
Object:
DGCR8
(RNA binding proteins)
Original: Nucleolin#directly interacts with#DGCR8 and Drosha in nucleus
#18632
middle Confidence
Subject:
U8_small_nucleolar_RNA
(Small RNA)
→
is_essential_for
→
Object:
3'_rRNA_processing
(Molecular Processing)
Original: U8 small nucleolar RNA#is essential for#3' rRNA processing in mammalian cells
#18071
middle Confidence
Subject:
Nucleolin_expression
(Protein expression status)
→
is_prognostic_factor_for
→
Object:
overall_survival
(Survival)
Original: Nucleolin expression#is a prognostic factor for#overall survival in stage II PDA
#18070
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
is_upregulated_in
→
Object:
ductal_epithelial_cell
(Epithelial cells)
Original: Nucleolin expression#was higher in#PDAs and PDA cell lines than in nonneoplastic ductal epithelial cells
#18069
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
is_upregulated_in
→
Object:
PDA_cell_line
(Tumor cell lines)
Original: Nucleolin expression#was higher in#PDAs and PDA cell lines than in nonneoplastic ductal epithelial cells
#18068
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
is_upregulated_in
→
Object:
PDA
(Tumor type)
Original: Nucleolin expression#was higher in#PDAs and PDA cell lines than in nonneoplastic ductal epithelial cells
#17215
middle Confidence
Subject:
NCL
(Ribosomal proteins)
→
acts_as_receptor_for
→
Object:
Tipalpha
(Bacterial toxin protein)
Original: Nucleolin#acts as#a receptor for Tipalpha in mouse gastric cancer cells
#17198
middle Confidence
Subject:
Imp3
(Ribosomal proteins)
→
plays_role_in
→
Object:
pre-rRNA_processing
(RNA processing)
Original: Role of Imp3 in pre-rRNA processing#is#evolutionarily conserved
#17171
middle Confidence
Subject:
pp135
(protein)
→
is_involved_in
→
Object:
transcription_of_rRNA_genes
(Transcription process)
Original: pp135#is involved in#transcription of rRNA genes
#17127
middle Confidence
Subject:
SLERT_deletion
(Gene deletion)
→
impairs
→
Object:
rRNA_production
(Transcription product)
Original: SLERT deletion#impairs#pre-rRNA transcription and rRNA production
#17126
middle Confidence
Subject:
SLERT_deletion
(Gene deletion)
→
impairs
→
Object:
pre-rRNA_transcription
(Transcription process)
Original: SLERT deletion#impairs#pre-rRNA transcription and rRNA production
#17125
middle Confidence
Subject:
SLERT
(Long noncoding RNA)
→
enhances
→
Object:
pre-rRNA_transcription
(Transcription process)
Original: SLERT#enhances#pre-rRNA transcription
#17075
middle Confidence
Subject:
DHX33_K94R_mutant
(DEAD/DEAH-box helicase mutants)
→
inhibits
→
Object:
endogenous_rRNA_synthesis
(rRNA synthesis)
Original: NTPase-defective DHX33 mutant (K94R)#inhibited#endogenous rRNA synthesis
#17074
middle Confidence
Subject:
DHX33
(DEAD/DEAH-box helicase)
→
overexpression_enhances
→
Object:
47S_rRNA_synthesis
(rRNA synthesis)
Original: Wild-type DHX33 overexpression#enhanced#47S rRNA synthesis
#17073
middle Confidence
Subject:
DHX33
(DEAD/DEAH-box helicase)
→
knockdown_decreases
→
Object:
rRNA_synthesis
(rRNA synthesis)
Original: DHX33 knockdown#decreased#association of Pol I with rDNA and rRNA synthesis
#17072
middle Confidence
Subject:
DHX33
(DEAD/DEAH-box helicase)
→
knockdown_decreases
→
Object:
Pol_I_association_with_rDNA
(Molecular complex)
Original: DHX33 knockdown#decreased#association of Pol I with rDNA and rRNA synthesis
#17056
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
modifies
→
Object:
nucleolus_shape_and_structure
(Subcellular structure)
Original: Depletion of nucleolin#modifies#the shape and structure of the nucleolus
#17047
middle Confidence
Subject:
KRAS4B
(Small GTPases)
→
localization_is_downregulated_by
→
Object:
Nucleolin
(Ribosomal proteins)
Original: Nucleolin knockdown#eliminates#nucleolar localization of K-Ras4B
#17046
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
knockdown_eliminates
→
Object:
nucleolar_localization_of_KRAS4B
(Protein localization process)
Original: Nucleolin knockdown#eliminates#nucleolar localization of K-Ras4B
#17027
middle Confidence
Subject:
NS1
(Viral Protein)
→
induces
→
Object:
nucleolar_stress
(Cellular stress process)
Original: Non-structural protein 1 of H3N2 influenza A virus#induces#nucleolar stress via interaction with nucleolin
#17026
middle Confidence
Subject:
NS1
(Viral Protein)
→
interacts_with
→
Object:
NCL
(Ribosome-associated proteins)
Original: Non-structural protein 1 of H3N2 influenza A virus#induces#nucleolar stress via interaction with nucleolin
#17017
middle Confidence
Subject:
TERF2
(Telomere binding protein)
→
binds_to
→
Object:
rDNA
(RNA)
Original: Nucleolar TRF2#binds#rDNA and promotes rRNA transcription
#16965
middle Confidence
Subject:
nucleolus
(Subcellular structure)
→
is_site_of
→
Object:
preribosomal_particle_maturation
(Molecular Process)
Original: Nucleolus#is the site of#ribosomal gene transcription/ rRNA processing/ and preribosomal particle maturation
#16964
middle Confidence
Subject:
nucleolus
(Subcellular structure)
→
is_site_of
→
Object:
rRNA_processing
(Molecular Process)
Original: Nucleolus#is the site of#ribosomal gene transcription/ rRNA processing/ and preribosomal particle maturation
#16963
middle Confidence
Subject:
nucleolus
(Subcellular structure)
→
is_site_of
→
Object:
ribosomal_gene_transcription
(Molecular Process)
Original: Nucleolus#is the site of#ribosomal gene transcription/ rRNA processing/ and preribosomal particle maturation
#16893
middle Confidence
Subject:
EP300
(Histone acetyltransferase)
→
mediates
→
Object:
lactylation_of_NCL
(Protein modification)
Original: Nucleolin#is lactylated at#lysine 477 by P300
#16892
middle Confidence
Subject:
nucleolar_and_ribosomal_protein_mutations
(Gene mutation)
→
affect
→
Object:
rRNA_processing
(RNA processing)
Original: Mutations in nucleolar and ribosomal proteins#affect#rRNA processing
#16875
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
serves_as
→
Object:
binding_protein_for_ligands_involved_in_angiogenesis
(Ligand Binding Protein)
Original: Nucleolin#serves as#a binding protein for ligands implicated in proliferation/ differentiation/ adhesion/ mitogenesis/ and angiogenesis
#16874
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
serves_as
→
Object:
binding_protein_for_ligands_involved_in_mitogenesis
(Ligand Binding Protein)
Original: Nucleolin#serves as#a binding protein for ligands implicated in proliferation/ differentiation/ adhesion/ mitogenesis/ and angiogenesis
#16873
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
serves_as
→
Object:
binding_protein_for_ligands_involved_in_adhesion
(Ligand Binding Protein)
Original: Nucleolin#serves as#a binding protein for ligands implicated in proliferation/ differentiation/ adhesion/ mitogenesis/ and angiogenesis
#16872
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
serves_as
→
Object:
binding_protein_for_ligands_involved_in_differentiation
(Ligand Binding Protein)
Original: Nucleolin#serves as#a binding protein for ligands implicated in proliferation/ differentiation/ adhesion/ mitogenesis/ and angiogenesis
#16871
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
serves_as
→
Object:
binding_protein_for_ligands_involved_in_proliferation
(Ligand Binding Protein)
Original: Nucleolin#serves as#a binding protein for ligands implicated in proliferation/ differentiation/ adhesion/ mitogenesis/ and angiogenesis
#16870
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
is_expressed_on
→
Object:
cell_surface
(Cell membrane)
Original: Nucleolin#is expressed on#the cell surface
#16820
middle Confidence
Subject:
PTEN
(Protein coding genes)
→
Dephosphorylates
→
Object:
nucleolin
(protein)
Original: PTEN�?localizes in#the nucleolus and dephosphorylates nucleolin
#16808
middle Confidence
Subject:
fibrillar_centers_adjacent_region
(Cellular substructure)
→
represented
→
Object:
site_of_rRNA_transcription
(Transcription region)
Original: fibrillar centers adjacent regions (FCARs)#represent#sites of ribosomal RNA (rRNA) transcription
#16770
middle Confidence
Subject:
interphase_AgNORs
(Nucleolus-related organic silver reactants)
→
is_related_to
→
Object:
rRNA_transcriptional_activity
(Transcriptional activity)
Original: Number of interphase AgNORs#is related to#rRNA transcriptional activity
#16113
middle Confidence
Subject:
rRNA_transcription_inhibition
(Transcriptional repression)
→
induces
→
Object:
apoptotic_proteins_activation
(Apoptosis)
Original: Transcriptional inhibition of rRNA#induces#G1 arrest and activation of apoptotic proteins
#16112
middle Confidence
Subject:
rRNA_transcription_inhibition
(Transcriptional repression)
→
induces
→
Object:
G1_arrest
(Cell cycle arrest)
Original: Transcriptional inhibition of rRNA#induces#G1 arrest and activation of apoptotic proteins
#14649
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
is_overexpressed_in
→
Object:
rapidly_dividing_cells
(Cell Type)
Original: Nucleolin#is overexpressed in#rapidly dividing cells
#12715
middle Confidence
Subject:
p34cdc2_kinase
(Protein kinase)
→
regulates
→
Object:
Nucleolin
(Ribosome-associated proteins)
Original: Nucleolin#is under control of#p34cdc2 kinase
#12714
middle Confidence
Subject:
Nucleolin
(Ribosome-associated proteins)
→
Controls
→
Object:
rDNA_transcription
(Transcription process)
Original: Nucleolin#controls#rDNA transcription
#12610
middle Confidence
Subject:
LSC
(Laser Scanning Cytometer)
→
measures
→
Object:
nucleolin_expression
(Protein expression)
Original: Laser scanning cytometer (LSC)#analyzes#nucleoli and measures expression of nucleolar protein nucleolin (NCL)
#12544
middle Confidence
Subject:
dFLCN_overexpression
(Upregulated gene expression)
→
reduces
→
Object:
rRNA_transcription
(rRNA transcription)
Original: dFLCN overexpression#reduces#rRNA transcription
#12491
middle Confidence
Subject:
MSP58
(Ribosome-associated proteins)
→
is_associated_with
→
Object:
cell_proliferation
(Cellular Processes)
Original: MSP58#is associated with#rRNA transcription and cell proliferation
#12476
middle Confidence
Subject:
nucleolin_mutant
(Protein mutants)
→
shows
→
Object:
redundant_function_in_nucleolar_shape
(Functional redundancy)
Original: Mutants of nucleolin#show#redundant functions in transcription/ rRNA maturation/ and nucleolar shape
#12475
middle Confidence
Subject:
nucleolin_mutant
(Protein mutants)
→
shows
→
Object:
redundant_function_in_rRNA_maturation
(Functional redundancy)
Original: Mutants of nucleolin#show#redundant functions in transcription/ rRNA maturation/ and nucleolar shape
#12474
middle Confidence
Subject:
nucleolin_mutant
(Protein mutants)
→
shows
→
Object:
redundant_function_in_transcription
(Functional redundancy)
Original: Mutants of nucleolin#show#redundant functions in transcription/ rRNA maturation/ and nucleolar shape
#12473
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
depletion
→
Object:
pre-rRNA_processing
(rRNA processing)
Original: Depletion of nucleolin#slightly affects#pre-rRNA processing
#12472
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
redistributes_to
→
Object:
nucleoplasm
(Subcellular structure)
Original: DeltaAg and nucleolin#redistribute#to the nucleoplasm under cell stress
#12471
middle Confidence
Subject:
DeltaAg
(Viral Protein)
→
redistributes
→
Object:
nucleolin
(Ribosomal proteins)
Original: DeltaAg and nucleolin#redistribute#to the nucleoplasm under cell stress
#12466
middle Confidence
Subject:
RPL22
(Ribosomal proteins)
→
stimulates
→
Object:
transcription_of_rRNAs
(Gene transcription)
Original: RPL22-dependent breakdown of heterochromatin#stimulates#transcription of rRNAs
#12452
middle Confidence
Subject:
disruption_of_NS1_NCL_interaction
(Experimental operation)
→
restores
→
Object:
RNA_Pol_I_dependent_transcription
(Transcription process)
Original: Disruption of NS1-nucleolin interaction#revived#RNA Pol I-dependent transcription
#12451
middle Confidence
Subject:
NS1
(Viral Protein)
→
binds_to
→
Object:
NCL
(Ribosome-associated proteins)
Original: Disruption of NS1-nucleolin interaction#revived#RNA Pol I-dependent transcription
#12448
middle Confidence
Subject:
JUN
(Transcription Factors)
→
affects
→
Object:
rRNA_processing
(Molecular modification regulation)
Original: c-Jun depletion#affects#rRNA processing
#12390
middle Confidence
Subject:
NMD3
(Nuclear export adaptor protein)
→
couples
→
Object:
rRNA_processing_pathway
(rRNA processing pathway)
Original: CRM1 and NMD3#couple#rRNA synthesis and processing pathways
#12389
middle Confidence
Subject:
CRM1
(Nuclear export receptor protein)
→
couples
→
Object:
rRNA_synthesis_pathway
(rRNA synthesis pathway)
Original: CRM1 and NMD3#couple#rRNA synthesis and processing pathways
#12388
middle Confidence
Subject:
CRM1
(Nuclear export receptor protein)
→
inhibition_inhibits
→
Object:
28S_rRNA_processing
(rRNA processing)
Original: CRM1 inhibition#inhibits#28S rRNA processing
#12301
middle Confidence
Subject:
lactate
(Metabolites)
→
is_generated_by
→
Object:
Glycolysis
(Metabolic pathways)
Original: Glycolysis#promotes#P300-catalyzed lactylation of nucleolin
#12300
middle Confidence
Subject:
NCL
(Ribosomal proteins)
→
is_lactylated_at
→
Object:
lysine_477
(Amino acid position)
Original: Nucleolin#is lactylated at#lysine 477 by P300
#12212
middle Confidence
Subject:
mutant_rRNA_processing_factors
(Ribosome biogenesis-related factors)
→
blocks
→
Object:
processing_of_36S/32S_precursors_to_28S_rRNA
(rRNA processing events)
Original: Mutants#blocked#processing of 36S/32S precursors to mature 28S rRNA
#12182
middle Confidence
Subject:
PTEN
(Protein coding genes)
→
localizes_in
→
Object:
nucleolus
(Organelles)
Original: PTEN�?localizes in#the nucleolus and dephosphorylates nucleolin
#12164
middle Confidence
Subject:
the_drug
(Small molecule compounds)
→
blocks
→
Object:
pre-rRNA_processing
(RNA processing)
Original: pre-rRNA processing#is blocked by#the drug
#12159
middle Confidence
Subject:
PES1
(Nucleolar proteins)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12158
middle Confidence
Subject:
GPC2
(Glycoprotein)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12157
middle Confidence
Subject:
NPM1
(Ribosomal proteins)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12156
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
is_a_member_of
→
Object:
key_nucleolar_protein
(protein)
Original: key nucleolar proteins#included#Nucleolin/ Nucleophosmin-1/ Glypican-2/ and PES-1
#12133
middle Confidence
Subject:
nucleophosmin
(Ribosomal proteins)
→
is_associated_with
→
Object:
interphase_AgNORs
(Nucleolus-related organic silver reactants)
Original: Nucleolin and nucleophosmin#are associated with#interphase AgNORs
#12132
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
is_associated_with
→
Object:
interphase_AgNORs
(Nucleolus-related organic silver reactants)
Original: Nucleolin and nucleophosmin#are associated with#interphase AgNORs
#12021
middle Confidence
Subject:
Fibrillar_centers
(Subcellular structure)
→
are_the_sites_of
→
Object:
rRNA_gene_transcription
(Transcription process)
Original: Fibrillar centers#are the sites of#rRNA gene transcription in Ehrlich tumor cell nucleoli
#12006
middle Confidence
Subject:
hNopp140N382
(Mutant protein)
→
inhibits
→
Object:
rRNA_gene_transcription
(rRNA gene transcription)
Original: hNopp140N382 protein#shut off#rRNA gene transcription
#11553
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
acts_as
→
Object:
signaling_molecule
(signaling molecule)
Original: Nucleolin#is used as#a signaling molecule to initiate inhibitory responses
#11237
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
plays_essential_role_in
→
Object:
cell_survival
(Cellular Processes)
Original: Nucleolin#plays#an essential role in cell proliferation and survival
#11236
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
plays_essential_role_in
→
Object:
cell_proliferation
(Cellular Processes)
Original: Nucleolin#plays#an essential role in cell proliferation and survival
#10756
middle Confidence
Subject:
nuclear_localization_of_MSP58
(Subcellular localization characteristics)
→
is_crucial_for
→
Object:
transcriptional_regulation_of_p21
(Transcriptional regulation process)
Original: nuclear and nucleolar localization of MSP58#is crucial for#transcriptional regulation of p21 and ribosomal RNA genes
#10755
middle Confidence
Subject:
MSP58
(Ribosome-associated proteins)
→
is_associated_with
→
Object:
rRNA_transcription
(Molecular Process)
Original: MSP58#is associated with#rRNA transcription and cell proliferation
#10748
middle Confidence
Subject:
Nucleolin
(Ribosomal proteins)
→
is_characterized_by
→
Object:
nucleolar-like_nuclear_appearance
(Nuclear morphology)
Original: Nucleolin#is characterized by#a nucleolar-like nuclear appearance
#8593
middle Confidence
Subject:
PDA_cell_line
(Cell lines)
→
shows
→
Object:
nucleolar_staining_for_nucleolin
(Protein localization)
Original: PDAs and PDA cell lines#showed#nucleolar staining for nucleolin
#8592
middle Confidence
Subject:
PDA
(Tumor type)
→
shows
→
Object:
nucleolar_staining_for_nucleolin
(Protein localization)
Original: PDAs and PDA cell lines#showed#nucleolar staining for nucleolin
#8591
middle Confidence
Subject:
Nucleolin_expression
(Protein expression)
→
is_evaluated_by
→
Object:
Immunohistochemistry
(Detection Technology)
Original: Nucleolin expression#was evaluated by#immunohistochemistry
#6634
middle Confidence
Subject:
pre-rRNA_processing
(RNA processing)
→
is
→
Object:
evolutionarily_conserved
(Biological characteristics)
Original: Role of Imp3 in pre-rRNA processing#is#evolutionarily conserved
#6629
middle Confidence
Subject:
LSC
(Laser Scanning Cytometer)
→
analyzes
→
Object:
nucleoli
(Cellular substructure)
Original: Laser scanning cytometer (LSC)#analyzes#nucleoli and measures expression of nucleolar protein nucleolin (NCL)
#6615
middle Confidence
Subject:
NPM_mutation
(Gene mutation)
→
impacts
→
Object:
interaction_with_nucleolin
(Protein Interactions)
Original: NPM mutation#impacts#interaction with nucleolin (NCL) in nucleolus
#6549
middle Confidence
Subject:
ribosome_biogenesis
(Ribosome biogenesis)
→
includes
→
Object:
ribosomal_protein_biosynthesis
(Molecular Process)
Original: Ribosome biogenesis#includes#making and processing of ribosomal RNAs and biosynthesis of ribosomal proteins
#6548
middle Confidence
Subject:
ribosome_biogenesis
(Ribosome biogenesis)
→
includes
→
Object:
ribosomal_RNA_processing
(Molecular Process)
Original: Ribosome biogenesis#includes#making and processing of ribosomal RNAs and biosynthesis of ribosomal proteins
#6544
middle Confidence
Subject:
nuclear_localization_of_MSP58
(Subcellular localization characteristics)
→
is_crucial_for
→
Object:
transcriptional_regulation_of_ribosomal_RNA_genes
(Transcriptional regulation process)
Original: nuclear and nucleolar localization of MSP58#is crucial for#transcriptional regulation of p21 and ribosomal RNA genes
#6528
middle Confidence
Subject:
Nuclear_export_of_ribosomes
(Molecular Process)
→
is_increased_in
→
Object:
absence_of_ARF
(Gene deletion status)
Original: Transcription of rDNA/ processing of rRNA/ and nuclear export of ribosomes#are increased in#absence of ARF
#6527
middle Confidence
Subject:
Processing_of_rRNA
(Molecular Process)
→
is_increased_in
→
Object:
absence_of_ARF
(Gene deletion status)
Original: Transcription of rDNA/ processing of rRNA/ and nuclear export of ribosomes#are increased in#absence of ARF
#6526
middle Confidence
Subject:
Transcription_of_rDNA
(Molecular Process)
→
is_increased_in
→
Object:
absence_of_ARF
(Gene deletion status)
Original: Transcription of rDNA/ processing of rRNA/ and nuclear export of ribosomes#are increased in#absence of ARF
#6511
middle Confidence
Subject:
UBF
(Transcription Factors)
→
is_in_close_spatial_proximity_with
→
Object:
pKi-67
(Nuclear matrix proteins)
Original: UBF#is in close spatial proximity with#pKi-67
#6505
middle Confidence
Subject:
MMP2
(Matrix Metalloproteinases)
→
mediates
→
Object:
rRNA_transcription
(Transcription process)
Original: Matrix metalloproteinase-2#mediates#ribosomal RNA transcription by cleaving nucleolar histones
#6439
middle Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_localized_in
→
Object:
cell_membrane
(Cell membrane)
Original: Nucleolin#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#6438
middle Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_localized_in
→
Object:
Cytoplasm
(Cell compartment)
Original: Nucleolin#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#6437
middle Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_localized_in
→
Object:
nucleoplasm
(Organelles)
Original: Nucleolin#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#6436
middle Confidence
Subject:
NCL
(Ribonucleoprotein)
→
is_localized_in
→
Object:
nucleolus
(Organelles)
Original: Nucleolin#is localized in#nucleolus/ nucleoplasm/ cytoplasm/ and cell membrane
#6402
middle Confidence
Subject:
aluRNAs
(Noncoding RNA)
→
depletion_impairs
→
Object:
RNA_pol_I_transcription_of_rRNA_genes
(Transcription process)
Original: Antisense-oligo-mediated depletion of aluRNAs#disrupted#nucleolar structure and impaired RNA polymerase I-dependent transcription of rRNA genes
#6401
middle Confidence
Subject:
aluRNAs
(Noncoding RNA)
→
depletion_disrupts
→
Object:
nucleolar_structure
(Cell structure)
Original: Antisense-oligo-mediated depletion of aluRNAs#disrupted#nucleolar structure and impaired RNA polymerase I-dependent transcription of rRNA genes
#6393
middle Confidence
Subject:
nucleolus
(Organelles)
→
facilitates
→
Object:
processing_of_rRNA
(rRNA processing)
Original: The nucleolus#facilitates#transcription and processing of rRNA
#6392
middle Confidence
Subject:
nucleolus
(Organelles)
→
facilitates
→
Object:
transcription_of_rRNA
(rRNA transcription)
Original: The nucleolus#facilitates#transcription and processing of rRNA
#6376
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
redistribution_precedes
→
Object:
histone_phosphorylation_decrease
(Epigenetic modification)
Original: redistribution of nucleolin#precedes#decrease of histone acetylation and phosphorylation
#6375
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
redistribution_precedes
→
Object:
histone_acetylation_decrease
(Epigenetic modification)
Original: redistribution of nucleolin#precedes#decrease of histone acetylation and phosphorylation
#6374
middle Confidence
Subject:
nucleolin
(Ribosomal proteins)
→
redistributes_from
→
Object:
nucleolus
(Cellular substructure)
Original: nucleolin#redistributes from#nucleolus after 6 hours
#5918
middle Confidence
Subject:
Ki-67
(Cell cycle proteins)
→
included_in
→
Object:
cell_proliferation_measurement_techniques
(Detection Methods)
Original: techniques for measuring cell proliferation#include#mitosis counting/ AgNORs/ DNA precursor uptake/ and immunohistochemical detection of cell cycle proteins (PCNA/ Ki-67/MIB-1)
#5917
middle Confidence
Subject:
PCNA
(Cell cycle proteins)
→
included_in
→
Object:
cell_proliferation_measurement_techniques
(Detection Methods)
Original: techniques for measuring cell proliferation#include#mitosis counting/ AgNORs/ DNA precursor uptake/ and immunohistochemical detection of cell cycle proteins (PCNA/ Ki-67/MIB-1)
#5916
middle Confidence
Subject:
DNA_precursor_uptake
(Molecular detection methods)
→
included_in
→
Object:
cell_proliferation_measurement_techniques
(Detection Methods)
Original: techniques for measuring cell proliferation#include#mitosis counting/ AgNORs/ DNA precursor uptake/ and immunohistochemical detection of cell cycle proteins (PCNA/ Ki-67/MIB-1)
#5915
middle Confidence
Subject:
AgNORs
(Molecular markers)
→
included_in
→
Object:
cell_proliferation_measurement_techniques
(Detection Methods)
Original: techniques for measuring cell proliferation#include#mitosis counting/ AgNORs/ DNA precursor uptake/ and immunohistochemical detection of cell cycle proteins (PCNA/ Ki-67/MIB-1)
#5914
middle Confidence
Subject:
mitosis_counting
(Cellular process detection technology)
→
included_in
→
Object:
cell_proliferation_measurement_techniques
(Detection Methods)
Original: techniques for measuring cell proliferation#include#mitosis counting/ AgNORs/ DNA precursor uptake/ and immunohistochemical detection of cell cycle proteins (PCNA/ Ki-67/MIB-1)
#4382
low Confidence
Subject:
Nucleolin_expression
(Protein expression)
→
is_classified_as
→
Object:
nucleolin-low
(Expression typing)
Original: Nucleolin expression#was classified as#nucleolin-high or nucleolin-low
#4381
low Confidence
Subject:
Nucleolin_expression
(Protein expression)
→
is_classified_as
→
Object:
nucleolin-high
(Expression typing)
Original: Nucleolin expression#was classified as#nucleolin-high or nucleolin-low
#3941
low Confidence
Subject:
nucleolin_expression
(Protein expression)
→
has_no_significant_correlation_with
→
Object:
clinicopathologic_parameters
(Clinical parameters)
Original: Nucleolin expression#has no significant correlation with#clinicopathologic parameters
#2133
low Confidence
Subject:
PNC_components
(Subnucleolar structural components)
→
include
→
Object:
RNA-binding_proteins
(RNA binding proteins)
Original: PNC components#include#RNA-binding proteins implicated in pre-mRNA processing
#751
low Confidence
Subject:
inhibition_of_pre-rRNA_processing
(Molecular Process)
→
might_result_from
→
Object:
impairment_of_controlling_factors
(Molecular regulation)
Original: Inhibition of pre-rRNA processing#might result from#impairment of controlling factors
#734
low Confidence
Subject:
NCL
(Ribosome-associated proteins)
→
coordinately_controlled_with
→
Object:
RRP1
(Ribosomal proteins)
Original: Expression of nucleolin and NO38#is controlled#coordinately
#706
low Confidence
Subject:
plasma_cells
(Immune cells)
→
exhibit
→
Object:
active_protein_synthesis
(Molecular Process)
Original: lymphocytes#included#various degrees of maturation and/or differentiation as well as plasma cells exhibiting active protein synthesis
#144
low Confidence
Subject:
PHF6
(Nucleolar proteins)
→
was_analyzed_for
→
Object:
mechanisms_of_NGR1
(Molecular mechanism)
Original: DNA-damage-related proteins/ including H2AX/ ATR/ and p53/ and nucleolus protein PHF6#were analyzed#to investigate mechanisms of NGR1
#143
low Confidence
Subject:
TP53
(Tumor suppressor proteins)
→
was_analyzed_for
→
Object:
mechanisms_of_NGR1
(Molecular mechanism)
Original: DNA-damage-related proteins/ including H2AX/ ATR/ and p53/ and nucleolus protein PHF6#were analyzed#to investigate mechanisms of NGR1
#142
low Confidence
Subject:
ATR
(DNA damage-associated proteins)
→
was_analyzed_for
→
Object:
mechanisms_of_NGR1
(Molecular mechanism)
Original: DNA-damage-related proteins/ including H2AX/ ATR/ and p53/ and nucleolus protein PHF6#were analyzed#to investigate mechanisms of NGR1
#141
low Confidence
Subject:
H2AX
(DNA damage-associated proteins)
→
was_analyzed_for
→
Object:
mechanisms_of_NGR1
(Molecular mechanism)
Original: DNA-damage-related proteins/ including H2AX/ ATR/ and p53/ and nucleolus protein PHF6#were analyzed#to investigate mechanisms of NGR1
#133
low Confidence
Subject:
lymphocytes
(Immune cells)
→
show
→
Object:
differentiation
(Cellular Processes)
Original: lymphocytes#included#various degrees of maturation and/or differentiation as well as plasma cells exhibiting active protein synthesis
#132
low Confidence
Subject:
lymphocytes
(Immune cells)
→
show
→
Object:
maturation
(Cellular Processes)
Original: lymphocytes#included#various degrees of maturation and/or differentiation as well as plasma cells exhibiting active protein synthesis