Search results of triples
A total of 75 records found
#21652
high Confidence
Subject:
NPM1
(Nucleolar proteins)
→
facilitates
→
Object:
ribosome_biogenesis
(Molecular complex synthesis)
Original: NPM1#facilitates#ribosome biogenesis and nucleolar stress responses
#21566
high Confidence
Subject:
MDM2
(Ubiquitin ligase)
→
binds_to
→
Object:
RPL11
(Ribosomal proteins)
Original: RPL11#binds#MDM2 to centralize the nucleolar stress-sensing pathway
#21565
high Confidence
Subject:
RPL11
(Ribosomal proteins)
→
binds_to
→
Object:
MDM2
(Ubiquitin ligase)
Original: RPL11#binds#MDM2 to centralize the nucleolar stress-sensing pathway
#20553
high Confidence
Subject:
Western-blot_analysis
(Molecular analysis technology)
→
determines
→
Object:
p53_expression
(Protein expression)
Original: Western-blot analysis#determines#cell senescence-related markers (p16/ p21/ p53)
#20552
high Confidence
Subject:
Western-blot_analysis
(Molecular analysis technology)
→
determines
→
Object:
p21_expression
(Protein expression)
Original: Western-blot analysis#determines#cell senescence-related markers (p16/ p21/ p53)
#20551
high Confidence
Subject:
Western-blot_analysis
(Molecular analysis technology)
→
determines
→
Object:
p16_expression
(Protein expression)
Original: Western-blot analysis#determines#cell senescence-related markers (p16/ p21/ p53)
#20530
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN1C_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20529
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN1B_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20528
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN1A_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20527
high Confidence
Subject:
GSK2118436
(Small molecule drugs)
→
affects
→
Object:
CDKN2A_expression
(Protein expression)
Original: GSK2118436#affects#expression patterns of CDKI (p16/ p21/ p27/ p57)
#20361
high Confidence
Subject:
DHODH
(Enzymes)
→
inhibition_impairs
→
Object:
rDNA_transcription
(Transcription process)
Original: DHODH inhibition#impaired#rDNA transcription/ leading to nucleolar stress
#20092
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
ribosome_biogenesis
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#20091
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
centrosome_duplication
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#20084
high Confidence
Subject:
p14ARF
(Tumor suppressor proteins)
→
increases
→
Object:
p21_expression
(Protein expression)
Original: p14ARF#increases#transcription and expression of p21
#20064
high Confidence
Subject:
ZGar
(Virus)
→
leads_to
→
Object:
nucleolar_structural_disruption
(Changes in nucleolar structure)
Original: ZIKV infection#leads to#ribosomal stress and nucleolar structural disruption
#20063
high Confidence
Subject:
ZGar
(Virus)
→
leads_to
→
Object:
ribosomal_stress
(Stress response)
Original: ZIKV infection#leads to#ribosomal stress and nucleolar structural disruption
#20040
high Confidence
Subject:
nucleolar_stress
(Molecular stress response)
→
upregulates
→
Object:
p53
(Transcription Factors)
Original: nucleolar stress#upregulated#p53
#20000
high Confidence
Subject:
Nucleophosmin_1
(Nucleolar proteins)
→
regulates
→
Object:
nucleolar_stress_response
(Cellular Processes)
Original: Nucleophosmin 1 (NPM1)#regulates#centrosome duplication/ ribosome biogenesis and export/ histone assembly/ genomic stability/ and nucleolar stress response
#19918
middle Confidence
Subject:
NPM1
(Nucleolar proteins)
→
facilitates
→
Object:
nucleolar_stress_response
(Cellular stress response)
Original: NPM1#facilitates#ribosome biogenesis and nucleolar stress responses
#19885
middle Confidence
Subject:
nucleolar_stress
(Cellular stress)
→
induces
→
Object:
MYBBP1A_translocation
(Changes in protein localization)
Original: Nucleolar stress#induces#translocation of MYBBP1A to nucleoplasm
#19882
middle Confidence
Subject:
ribosomal_proteins
(Ribosomal proteins)
→
play_important_role_in
→
Object:
p53_activation_in_response_to_nucleolar_stress
(Stress response)
Original: Ribosomal proteins#play an important role in#p53 activation in response to nucleolar stress
#19020
middle Confidence
Subject:
ribosome_formation_failure
(Ribosome assembly disorder)
→
results_in
→
Object:
p53_mediated_apoptosis
(Apoptosis)
Original: Failure of ribosome formation#results in#nucleolar stress and p53-mediated apoptosis
#19019
middle Confidence
Subject:
ribosome_formation_failure
(Ribosome assembly disorder)
→
results_in
→
Object:
nucleolar_stress
(Subcellular stress)
Original: Failure of ribosome formation#results in#nucleolar stress and p53-mediated apoptosis
#19012
middle Confidence
Subject:
nucleolar_lncRNAs
(Long noncoding RNA)
→
ensure
→
Object:
cessation_of_rRNA_synthesis_during_stress
(Transcriptional regulatory events)
Original: Nucleolar lncRNAs#ensure#cessation of rRNA synthesis during stress adaptation
#19011
middle Confidence
Subject:
nucleolar_lncRNAs
(Long noncoding RNA)
→
respond_to
→
Object:
environmental_stressors
(Environmental factors)
Original: lncRNAs in the nucleolus#respond to#environmental stressors
#18983
middle Confidence
Subject:
cytostatics
(Chemotherapy drugs)
→
induce
→
Object:
nucleolar_phenotype_changes
(Cell phenotype changes)
Original: Cytostatics-induced changes of nucleolar phenotype#point to#a potential role of nucleolar components in the execution of active cell death
#18944
middle Confidence
Subject:
ras_p21
(Small G protein)
→
is_lower_in
→
Object:
non_progressing_cases
(Tumor cells)
Original: expression of ras p21#is greater in#progressing stage A cancer cells compared to non-progressing cases
#18943
middle Confidence
Subject:
ras_p21
(Small G protein)
→
is_higher_in
→
Object:
progressing_stage_A_cancer_cells
(Tumor cells)
Original: expression of ras p21#is greater in#progressing stage A cancer cells compared to non-progressing cases
#18903
middle Confidence
Subject:
Green_tea
(Natural Products)
→
significantly_reduced
→
Object:
ras-p21_expression
(Protein expression)
Original: Green tea#significantly reduced#ras-p21 expression
#18659
middle Confidence
Subject:
WDR75
(Ribosomal histones)
→
relocates_to
→
Object:
nucleolar_caps
(Subcellular structure)
Original: WDR75#relocates to#nucleolar caps under chemically induced nucleolar stress
#17184
middle Confidence
Subject:
PSMD9
(Proteasome regulatory subunits)
→
protects
→
Object:
WT_MCF7_cell_growth
(Cell proliferation)
Original: PSMD9-Ribosomal Protein interaction#protects#WT MCF7 breast cancer cells from slow growth and eventual death under nucleolar stress
#17182
middle Confidence
Subject:
Actinomycin_D
(Chemotherapy drugs)
→
induces
→
Object:
p21_redistribution
(Changes in protein localization)
Original: Actinomycin D#induces#redistribution of p14/p21 from nucleolus to nucleoplasm
#17181
middle Confidence
Subject:
Actinomycin_D
(Chemotherapy drugs)
→
induces
→
Object:
p14_redistribution
(Changes in protein localization)
Original: Actinomycin D#induces#redistribution of p14/p21 from nucleolus to nucleoplasm
#17164
middle Confidence
Subject:
chemotherapeutic_drugs
(drug)
→
affect
→
Object:
ribosome_biogenesis
(Molecular Process)
Original: Chemotherapeutic drugs#induce#nucleolar stress by affecting ribosome biogenesis in nucleolus
#17163
middle Confidence
Subject:
chemotherapeutic_drugs
(drug)
→
induce
→
Object:
nucleolar_stress
(Cellular stress)
Original: Chemotherapeutic drugs#induce#nucleolar stress by affecting ribosome biogenesis in nucleolus
#17079
middle Confidence
Subject:
ribosomal_proteins
(Ribosomal proteins)
→
control
→
Object:
tumor_suppressor_pathways
(signaling pathway)
Original: Ribosomal proteins#control#tumor suppressor pathways in response to nucleolar stress
#17066
middle Confidence
Subject:
TP53
(Tumor suppressor proteins)
→
induction_leads_to
→
Object:
CDKN1A_accumulation
(Cell cycle protein inhibitors)
Original: p53 induction#leads to#lineage-specific p21 accumulation and cell cycle arrest in erythroid progenitor cells
#17031
middle Confidence
Subject:
NS1
(Viral Protein)
→
induces
→
Object:
nucleolar_stress
(Cellular stress process)
Original: NS1 protein of H3N2#induces#nucleolar stress based on epigenetic alteration of rRNA gene promoter
#17027
middle Confidence
Subject:
NS1
(Viral Protein)
→
induces
→
Object:
nucleolar_stress
(Cellular stress process)
Original: Non-structural protein 1 of H3N2 influenza A virus#induces#nucleolar stress via interaction with nucleolin
#17026
middle Confidence
Subject:
NS1
(Viral Protein)
→
interacts_with
→
Object:
NCL
(Ribosome-associated proteins)
Original: Non-structural protein 1 of H3N2 influenza A virus#induces#nucleolar stress via interaction with nucleolin
#16992
middle Confidence
Subject:
nucleolar_stress
(Cellular stress state)
→
induces
→
Object:
apoptosis
(Cellular Processes)
Original: Nucleolar stress#induces#apoptosis
#16976
middle Confidence
Subject:
nucleolar_morphology
(Cell structure characteristics)
→
is_linked_to
→
Object:
stress_responses
(Cellular stress response)
Original: Alterations in nucleolar morphology and protein content#are linked to#control of cell proliferation and stress responses
#16975
middle Confidence
Subject:
nucleolar_morphology
(Cell structure characteristics)
→
is_linked_to
→
Object:
control_of_cell_proliferation
(Cellular Processes)
Original: Alterations in nucleolar morphology and protein content#are linked to#control of cell proliferation and stress responses
#16900
middle Confidence
Subject:
p14
(protein)
→
regulates
→
Object:
p53_stabilization
(Protein stability)
Original: p14#regulates#nucleolar stress response/ ribosome biogenesis/ and p53 stabilization
#16899
middle Confidence
Subject:
p14
(protein)
→
regulates
→
Object:
ribosome_biogenesis
(Ribosome biogenesis)
Original: p14#regulates#nucleolar stress response/ ribosome biogenesis/ and p53 stabilization
#16898
middle Confidence
Subject:
p14
(protein)
→
regulates
→
Object:
nucleolar_stress_response
(Cellular stress process)
Original: p14#regulates#nucleolar stress response/ ribosome biogenesis/ and p53 stabilization
#16793
middle Confidence
Subject:
mislocalization_of_DDX21
(Abnormal protein localization)
→
leads_to
→
Object:
reduction_in_ribosome_biogenesis
(Ribosome biogenesis)
Original: Mislocalization of DDX21#leads to#reduction in ribosome biogenesis and cancer cell growth
#16757
middle Confidence
Subject:
nucleolar_stress
(Cellular Processes)
→
impacts
→
Object:
genomic_stability
(Genome stability)
Original: Nucleoli#trigger#nucleolar stress impacting genomic stability
#16756
middle Confidence
Subject:
nucleoli
(Subcellular structure)
→
trigger
→
Object:
nucleolar_stress
(Cellular Processes)
Original: Nucleoli#trigger#nucleolar stress impacting genomic stability
#16711
middle Confidence
Subject:
berberine
(Small molecule drugs)
→
causes
→
Object:
nucleolar_stress_response
(Molecular stress response)
Original: berberine#caused#nucleolar stress response
#12569
middle Confidence
Subject:
nucleolar_targeting_signal_in_PML-I
(Protein domain)
→
addresses
→
Object:
PML
(protein)
Original: Nucleolar targeting signal in PML-I#addresses#PML to nucleolar caps in stressed or senescent cells
#12493
middle Confidence
Subject:
nucleolar_stress
(Cellular stress)
→
activates
→
Object:
JNK
(Mitogen-activated protein kinase)
Original: Nucleolar stress#activated#Jun N-terminal kinase (JNK) in Nopp140-depleted larvae
#12486
middle Confidence
Subject:
CDKN1A
(Cell cycle protein inhibitors)
→
accumulation_leads_to
→
Object:
cell_cycle_arrest
(Cellular Processes)
Original: p53 induction#leads to#lineage-specific p21 accumulation and cell cycle arrest in erythroid progenitor cells
#12357
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
supports
→
Object:
central_role_in_rDNA_transcription
(rDNA transcription regulation)
Original: NuMA#supports#a central role in rDNA transcription and p53-independent nucleolar stress response
#12356
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
downregulation_triggers
→
Object:
nucleolar_stress
(Cellular stress response)
Original: Downregulation of NuMA expression#triggers#nucleolar stress
#12355
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
is_involved_in
→
Object:
p53-mediated_growth_arrest
(Cell cycle arrest)
Original: NuMA#is involved in#DNA damage response/ apoptosis/ and p53-mediated growth arrest under nucleolar stress
#12354
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
is_involved_in
→
Object:
apoptosis
(Apoptosis)
Original: NuMA#is involved in#DNA damage response/ apoptosis/ and p53-mediated growth arrest under nucleolar stress
#12353
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
is_involved_in
→
Object:
DNA_damage_response
(Cellular stress response)
Original: NuMA#is involved in#DNA damage response/ apoptosis/ and p53-mediated growth arrest under nucleolar stress
#12345
middle Confidence
Subject:
Phytochemicals
(Plant active small molecules)
→
promote
→
Object:
RRN3_translocation
(Protein translocation)
Original: phytochemicals#promote#nucleolar stress via translocation of RNA polymerase I-specific transcription initiation factor RRN3/TIF-IA
#12344
middle Confidence
Subject:
Phytochemicals
(Plant active small molecules)
→
promote
→
Object:
nucleolar_stress
(Stress response)
Original: phytochemicals#promote#nucleolar stress via translocation of RNA polymerase I-specific transcription initiation factor RRN3/TIF-IA
#12246
middle Confidence
Subject:
ZIKV_C_C-terminal_residues_deletion
(Protein mutants)
→
prevents
→
Object:
ribosomal_stress
(Stress response)
Original: Deletion of ZIKV-C C-terminal residues#prevents#nucleolar localization and ribosomal stress
#12245
middle Confidence
Subject:
ZIKV_C_C-terminal_residues_deletion
(Protein mutants)
→
prevents
→
Object:
nucleolar_localization
(Subcellular localization)
Original: Deletion of ZIKV-C C-terminal residues#prevents#nucleolar localization and ribosomal stress
#12224
middle Confidence
Subject:
L11
(Ribosomal proteins)
→
NEDDylation_decreases_during
→
Object:
nucleolar_stress
(Cellular stress)
Original: L11 NEDDylation#decreases during#nucleolar stress
#12199
middle Confidence
Subject:
PPAN
(Ribosome biogenesis regulatory protein)
→
defines
→
Object:
p53_independent_nucleolar_stress_response_pathway
(Stress Pathway)
Original: Wnt Target Protein Peter Pan#defines#a novel p53-independent nucleolar stress-response pathway
#12000
middle Confidence
Subject:
DNA_damage_response
(Cellular Processes)
→
triggers
→
Object:
nucleolar_and_ribosomal_stress
(Molecular stress response)
Original: DNA damage response#triggered#nucleolar and ribosomal stress
#10756
middle Confidence
Subject:
nuclear_localization_of_MSP58
(Subcellular localization characteristics)
→
is_crucial_for
→
Object:
transcriptional_regulation_of_p21
(Transcriptional regulation process)
Original: nuclear and nucleolar localization of MSP58#is crucial for#transcriptional regulation of p21 and ribosomal RNA genes
#6544
middle Confidence
Subject:
nuclear_localization_of_MSP58
(Subcellular localization characteristics)
→
is_crucial_for
→
Object:
transcriptional_regulation_of_ribosomal_RNA_genes
(Transcriptional regulation process)
Original: nuclear and nucleolar localization of MSP58#is crucial for#transcriptional regulation of p21 and ribosomal RNA genes
#6484
middle Confidence
Subject:
NuMA
(Cytoskeletal proteins)
→
supports
→
Object:
p53-independent_nucleolar_stress_response
(Cellular stress response)
Original: NuMA#supports#a central role in rDNA transcription and p53-independent nucleolar stress response
#6483
middle Confidence
Subject:
nucleolar_stress
(Cellular stress response)
→
promotes
→
Object:
decrease_in_NuMA_amount
(Protein expression downregulation)
Original: Nucleolar stress#promotes#decrease in NuMA amount
#6482
middle Confidence
Subject:
nucleolar_stress
(Cellular stress response)
→
is_shown_by
→
Object:
upregulation_of_p27kip1
(Cell cycle regulatory proteins)
Original: Nucleolar stress#is shown by#decreased nascent pre-rRNA synthesis/ fibrillarin perinucleolar cap formation/ and upregulation of p27kip1
#6481
middle Confidence
Subject:
nucleolar_stress
(Cellular stress response)
→
is_shown_by
→
Object:
fibrillarin_perinucleolar_cap_formation
(Changes in nucleolar structure)
Original: Nucleolar stress#is shown by#decreased nascent pre-rRNA synthesis/ fibrillarin perinucleolar cap formation/ and upregulation of p27kip1
#6480
middle Confidence
Subject:
nucleolar_stress
(Cellular stress response)
→
is_shown_by
→
Object:
decreased_nascent_pre-rRNA_synthesis
(rRNA synthesis)
Original: Nucleolar stress#is shown by#decreased nascent pre-rRNA synthesis/ fibrillarin perinucleolar cap formation/ and upregulation of p27kip1
#4640
middle Confidence
Subject:
MYC
(Proto-oncogene)
→
shows_normal_result_in
→
Object:
FISH_test
(Molecular detection methods)
Original: FISH#showed#normal results for 9p21 (CDKN2A) and 8q24 (MYC)
#4639
middle Confidence
Subject:
CDKN2A
(Tumor suppressor genes)
→
shows_normal_result_in
→
Object:
FISH_test
(Molecular detection methods)
Original: FISH#showed#normal results for 9p21 (CDKN2A) and 8q24 (MYC)
#105
low Confidence
Subject:
PPAN
(Ribosome biogenesis-associated protein)
→
function_unknown
→
Object:
nucleolar_stress_response
(Cellular stress response)
Original: The role of PPAN in nucleolar stress response#has remained#elusive